thiophenes has been researched along with 2-propyl-4,5,5a,6,7,11b-hexahydro-3-thia-5-azacyclopent-1-ena(c)phenanthrene-9,10-diol in 12 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (66.67) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Asin, KE; Britton, DR; DiDomenico, S; Hong, Y; Lin, CW; Michaelides, MR; Shiosaki, K; Williams, M | 1 |
| Asin, KE; Bianchi, B; Britton, DR; Didomenico, S; Hodges, L; Hong, Y; Jenner, P; Lin, CW; Mahan, L; Michaelides, M; Mikusa, J; Miller, T; Nikkel, A; Shiosaki, K; Smith, L; Stashko, M; Williams, M; Witte, D | 1 |
| Asin, KE; Bednarz, L; Britton, DR; Giardina, WJ; Mahan, L; Mikusa, J; Nikkel, A; Shiosaki, K; Wismer, C | 1 |
| Asin, KE; Domino, EF; Nikkel, A; Shiosaki, K | 1 |
| Asin, KE; Bayburt, EK; Britton, DR; DiDomenico, S; Hong, Y; Lin, CW; Michaelides, MR; Shiosaki, K | 1 |
| Bédard, PJ; Britton, DR; Grondin, R; Shiosaki, K | 1 |
| Britton, DR; Jackson, M; Jenner, P; Marsden, CD; Pearce, RK; Shiosaki, K | 1 |
| Adjei, AL; Bertz, RJ; El-Shourbagy, T; Marsh, KC; Zheng, Y | 1 |
| Jackson, M; Jenner, P; Treseder, SA | 1 |
| Tomioka, K; Yamada, K; Yamashita, M | 1 |
| Bar, S; Hajra, S | 1 |
| Ghiviriga, I; Horenstein, N; Li, H; Mirabel, R; Phidd, DK; Urs, NM; Zimmerman, J | 1 |
1 trial(s) available for thiophenes and 2-propyl-4,5,5a,6,7,11b-hexahydro-3-thia-5-azacyclopent-1-ena(c)phenanthrene-9,10-diol
| Article | Year |
|---|---|
Pulmonary delivery of a dopamine D-1 agonist, ABT-431, in dogs and humans.
Topics: Absorption; Adult; Aerosol Propellants; Aerosols; Animals; Area Under Curve; Biological Availability; Dogs; Dopamine Agonists; Double-Blind Method; Humans; Injections, Intravenous; Lung; Male; Nebulizers and Vaporizers; Particle Size; Prodrugs; Pyridines; Quinolones; Receptors, Dopamine D1; Tetrahydronaphthalenes; Thiophenes | 1999 |
11 other study(ies) available for thiophenes and 2-propyl-4,5,5a,6,7,11b-hexahydro-3-thia-5-azacyclopent-1-ena(c)phenanthrene-9,10-diol
| Article | Year |
|---|---|
(5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diac
Topics: Acetylation; Animals; Behavior, Animal; Drug Administration Schedule; Humans; Prodrugs; Protein Precursors; Pyridines; Quinolones; Rats; Receptors, Dopamine D1; Receptors, Dopamine D2; Structure-Activity Relationship; Tetrahydronaphthalenes; Thiophenes | 1995 |
ABT-431: the diacetyl prodrug of A-86929, a potent and selective dopamine D1 receptor agonist: in vitro characterization and effects in animal models of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Behavior, Animal; Callithrix; CHO Cells; Corpus Striatum; Cricetinae; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Female; Fishes; Humans; Kinetics; Male; Mice; Parkinson Disease, Secondary; Prodrugs; Pyridines; Quinolones; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Tetrahydronaphthalenes; Thiophenes | 1996 |
Hyperactivity and behavioral seizures in rodents following treatment with the dopamine D1 receptor agonists A-86929 and ABT-431.
Topics: Animals; Behavior, Animal; Benzazepines; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Male; Mice; Motor Activity; Oxidopamine; Prodrugs; Pyridines; Quinolones; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Seizures; Sympathectomy, Chemical; Tetrahydronaphthalenes; Thiophenes | 1996 |
The selective dopamine D1 receptor agonist A-86929 maintains efficacy with repeated treatment in rodent and primate models of Parkinson's disease.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Dopamine Agonists; Dose-Response Relationship, Drug; Macaca nemestrina; Male; Parkinson Disease; Pyridines; Quinolones; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Rotation; Tetrahydronaphthalenes; Thiophenes | 1997 |
Substituted hexahydrobenzo[f]thieno[c]quinolines as dopamine D1-selective agonists: synthesis and biological evaluation in vitro and in vivo.
Topics: Adenylyl Cyclases; Animals; Benzazepines; Binding, Competitive; Cell Membrane; Corpus Striatum; Dopamine Agonists; Dopamine Antagonists; Fishes; Mice; Molecular Structure; Oxidopamine; Parkinson Disease, Secondary; Quinolones; Receptors, Dopamine; Retina; Stereoisomerism; Structure-Activity Relationship; Thiophenes; Tritium; Yohimbine | 1997 |
Potential therapeutic use of the selective dopamine D1 receptor agonist, A-86929: an acute study in parkinsonian levodopa-primed monkeys.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Dopamine Agents; Dopamine Agonists; Dyskinesia, Drug-Induced; Female; Levodopa; Macaca fascicularis; Motor Activity; Parkinson Disease, Secondary; Quinolones; Quinpirole; Receptors, Dopamine D1; Thiophenes | 1997 |
Actions of the D1 agonists A-77636 and A-86929 on locomotion and dyskinesia in MPTP-treated L-dopa-primed common marmosets.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adamantane; Animals; Benzopyrans; Callithrix; Disease Models, Animal; Dopamine Agents; Dopamine Agonists; Dyskinesia, Drug-Induced; Female; Levodopa; Locomotion; Male; Quinolones; Receptors, Dopamine D1; Thiophenes | 1999 |
The effects of central aromatic amino acid DOPA decarboxylase inhibition on the motor actions of L-DOPA and dopamine agonists in MPTP-treated primates.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Behavior, Animal; Callithrix; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Hydrazines; Levodopa; Male; Motor Activity; Quinolones; Quinpirole; Thiophenes; Tyrosine | 2000 |
Construction of arene-fused-piperidine motifs by asymmetric addition of 2-trityloxymethylaryllithiums to nitroalkenes: the asymmetric synthesis of a dopamine D1 full agonist, A-86929.
Topics: Alkenes; Dopamine Agonists; Lithium; Nitro Compounds; Organometallic Compounds; Piperidines; Quinolones; Receptors, Dopamine D1; Stereoisomerism; Thiophenes | 2004 |
Catalytic enantioselective synthesis of A-86929, a dopamine D1 agonist.
Topics: Catalysis; Cyclization; Dopamine Agonists; Quinolones; Stereoisomerism; Thiophenes | 2011 |
Structure-Functional Selectivity Relationship Studies on A-86929 Analogs and Small Aryl Fragments toward the Discovery of Biased Dopamine D1 Receptor Agonists.
Topics: Animals; beta-Arrestins; Dopamine; Dopamine Agonists; GTP-Binding Proteins; Ligands; Quinolones; Receptors, Dopamine D1; Receptors, Dopamine D2; Thiophenes | 2022 |