thiophenes has been researched along with 2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide in 42 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (16.67) | 29.6817 |
| 2010's | 26 (61.90) | 24.3611 |
| 2020's | 9 (21.43) | 2.80 |
| Authors | Studies |
|---|---|
| Bolognese, BJ; Callahan, JF; Carlson, K; Davis, TG; Evans, C; Li, YH; Mellor, GW; Podolin, PL; Roshak, AK | 1 |
| Belvisi, MG; Birrell, MA; Catley, M; De Alba, J; Haj-Yahia, S; Hardaker, E; McCluskie, K; Newton, R; Pun, KT; Savage, TJ; Shaw, RJ; Watts, CJ; Wong, S | 1 |
| Belvisi, MG; Birrell, MA; Catley, MC; Collins, M; Haj-Yahia, S; Hardaker, EL; McCluskie, K; Wong, S | 1 |
| Cottam, HB; Endo, T; Enzler, T; Fukuda, T; James, DF; Karin, M; Kipps, TJ; Nishio, M | 1 |
| Belvisi, MG; Birrell, MA; Hardaker, E; Knowles, R; McCluskie, K | 1 |
| Barnes, PJ; Catley, MC; Donnelly, LE; Fenwick, PS; Newton, R; Rumsey, WL; Russell, RE; Tudhope, SJ | 1 |
| Adachi, T; Fukuda, K; Kondo, Y; Nishida, T | 1 |
| Brenner, C; Feldmann, M; Foxwell, BM; Foxwell, KM; Kanji, R; Turner, JJ; Wood, S | 1 |
| Basel, TJ; Becker, K; Rudack, C; Sachse, F; Weiss, D | 1 |
| Boakes, A; Crighton, D; Heikkila, T; Kaye, SJ; Mezna, M; Olson, MF; Pang, L; Rushbrooke, M; Schroder, E; Turnbull, A; Wheatley, E | 1 |
| Baumann, J; Davidoff, AM; Du, Z; Garner, JM; Morton, CL; Pfeffer, LM; Whitt, MA | 1 |
| Bliska, JB; Bumeister, R; David, E; Dinkova-Kostova, AT; Honda, T; Mierke, DF; Ojima, I; Ren, Y; Santosh Laxmi, YR; Shiavoni, KH; Trevino, I; Wigley, WC; Zheng, S; Zheng, Y | 1 |
| Koizume, S; Matsukuma, S; Miyagi, Y; Nakamura, Y; Sakuma, Y; Yamazaki, Y; Yoshihara, M | 1 |
| Adcock, IM; Belvisi, MG; Birrell, MA; Catley, MC; Davies, M; Eltom, S; Evans, SM; Grace, M; Kilty, I; Lawrence, T; Pasparakis, M; Rastrick, JM; Stevenson, CS | 1 |
| Bargou, RC; Giner, T; Maier, E; Rauert-Wunderlich, H; Siegmund, D; Stühmer, T; Wajant, H | 1 |
| Bai, Q; Chen, X; Du, Y; Hou, J; Nan, J; Wang, Q; Wang, Y; Yang, J; Zhang, J; Zhang, X; Zhu, N | 1 |
| Ireland, DJ; Keelan, JA; Kemp, MW; Newnham, JP; Payne, MS; Stinson, LF; Stock, SJ | 1 |
| Alvarado-Díaz, CP; Devoto, L; González-Ramos, R; Núñez, MT | 1 |
| Gaddipati, S; Kaplan, HJ; Kasetti, RB; Li, Q; Lu, Q; Miller, MC; Trent, JO | 1 |
| Cataldi, M; Felt, SA; Grdzelishvili, VZ; Shah, NR | 1 |
| Chu, D; Gao, J; Wang, Z | 1 |
| Cho, S; Choi, YS; Chon, SJ; Lee, BS; Seo, SK; Yun, BH | 1 |
| Carroll, SL; Cassady, KA; Jackson, JD; Li, L; Markert, JM | 1 |
| Inamdar, MS; Karp, JM; Levy, O; Martyn, K; Ranganath, SH; Tong, Z | 1 |
| Cataldi, M; Felt, SA; Grdzelishvili, VZ; Hastie, E; Moerdyk-Schauwecker, MJ; Steuerwald, N | 1 |
| Charles, AK; Ireland, DJ; Keelan, JA; Kemp, MW; Li, S; Nathan, EA; Newnham, JP; Stinson, LF | 1 |
| Bivona, TG; Chaib, I; Codony-Servat, C; Codony-Servat, J; de Los Llanos Gil, M; Karachaliou, N; Molina, MA; Ramirez, JL; Rosell, R; Solca, F | 1 |
| Dahlin, A; Jiang, X; Lu, Q; Tantisira, K; Weiss, ST | 1 |
| Bay-Jensen, AC; Hägglund, P; Karsdal, MA; Kayed, A; Kjelgaard-Petersen, CF; Mobasheri, A; Sharma, N; Thudium, CS | 1 |
| Gao, J; Wang, Z; Zhang, CY | 1 |
| Bhatti, FUR; Cho, H; Hasty, KA | 1 |
| Brands, RC; El-Mesery, M; Hartmann, S; Kübler, AC; Müller-Richter, UDA; Scheurer, MJJ; Seher, A | 1 |
| Davaritouchaee, M; Gao, J; Lin, W; Mancini, RJ; Nielsen, AE; Shi, X; Wang, Z; Zhang, CY | 1 |
| Fukuoka, N; Harada, M; Kataoka, T; Nakao, A; Nghia, VT; Nishida, A; Tanigaki, R | 1 |
| Backman, LJ; Chen, J; Danielson, P; Liu, H; Qu, M; Zhang, A; Zhang, W; Zhang, X; Zhou, Q | 1 |
| Pu, X; Wang, Z; Yang, J; Yang, Y; Zhang, N; Zhao, J | 1 |
| Cai, H; Fu, Y; Sun, Q; Tan, WS; Zhu, X | 1 |
| Bodendorf, U; Boettcher, A; Bornancin, F; Eder, J; Erbel, P; Farady, CJ; Fruhauf, A; Heiser, D; Kauffmann, M; Rubert, J; Schlapbach, A; Unterreiner, A | 1 |
| Chen, YY; He, LY; Hong, H; Lei, YT; Yang, YY; Zou, J | 1 |
| Higashi, Y; Kataoka, T; Miyake, Y; Nakao, A; Tanaka, Y; Tanigaki, R | 1 |
| Li, Z; Xiao, ZX; Yang, J; Zou, L | 1 |
| Backman, LJ; Danielson, P; Li, J; Zhou, X | 1 |
42 other study(ies) available for thiophenes and 2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide
| Article | Year |
|---|---|
Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IkappaB Kinase 2, TPCA-1 (2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflammatory cytokines and
Topics: Adenosine Triphosphate; Amides; Animals; Anti-Asthmatic Agents; Arthritis, Experimental; Binding, Competitive; Cell Proliferation; Chemokines; Collagen; Cytokines; Disease Models, Animal; Humans; I-kappa B Kinase; Interleukin-6; Interleukin-8; Lipopolysaccharides; Male; Mice; Mice, Inbred DBA; Monocytes; NF-kappa B; Protein Serine-Threonine Kinases; T-Lymphocytes; Thiophenes; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2005 |
Ikappa-B kinase-2 inhibitor blocks inflammation in human airway smooth muscle and a rat model of asthma.
Topics: Amides; Animals; Anti-Inflammatory Agents; Asthma; Budesonide; Cells, Cultured; Chemokine CCL11; Chemokines, CC; Dexamethasone; Disease Models, Animal; Drug Evaluation, Preclinical; Gene Expression; Granulocyte Colony-Stimulating Factor; Humans; I-kappa B Kinase; Inflammation; Interleukin-8; Muscle, Smooth; NF-kappa B; Rats; Respiratory System; Thiophenes | 2005 |
IkappaB kinase-2-independent and -dependent inflammation in airway disease models: relevance of IKK-2 inhibition to the clinic.
Topics: Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; DNA; Enzyme Inhibitors; Humans; I-kappa B Kinase; Interleukin-1; Lipopolysaccharides; Lung Diseases; Matrix Metalloproteinase 9; Pancreatic Elastase; Rats; Thiophenes; Tumor Necrosis Factor-alpha | 2006 |
BAFF and APRIL support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-kappaB pathway.
Topics: B-Cell Activating Factor; B-Cell Maturation Antigen; Carboxylic Acids; Cell Fractionation; Cell Survival; Flow Cytometry; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; NF-kappa B; Protein Kinase Inhibitors; Sensitivity and Specificity; Signal Transduction; Thiophenes; Transmembrane Activator and CAML Interactor Protein; Tumor Necrosis Factor Ligand Superfamily Member 13 | 2007 |
Utility of exhaled nitric oxide as a noninvasive biomarker of lung inflammation in a disease model.
Topics: Amides; Animals; Anti-Inflammatory Agents; Biomarkers; Budesonide; Disease Models, Animal; Exhalation; Lipopolysaccharides; Nitric Oxide; Pneumonia; Rats; Rats, Wistar; Respiratory System; Thiophenes | 2006 |
The role of IkappaB kinase 2, but not activation of NF-kappaB, in the release of CXCR3 ligands from IFN-gamma-stimulated human bronchial epithelial cells.
Topics: Amides; Animals; Bronchi; Cells, Cultured; Chemokines; Dexamethasone; Epithelial Cells; Gene Expression Regulation; Humans; I-kappa B Kinase; Interferon-gamma; Ligands; NF-kappa B; Phosphorylation; Protein Kinase Inhibitors; Protein Transport; Receptors, CXCR3; RNA, Messenger; Signal Transduction; STAT1 Transcription Factor; Thiophenes | 2007 |
Inhibition by a selective IkappaB kinase-2 inhibitor of interleukin-1-induced collagen degradation by corneal fibroblasts in three-dimensional culture.
Topics: Amides; Animals; Cells, Cultured; Collagen Type I; Cornea; Corneal Ulcer; Disease Models, Animal; Fibroblasts; Gene Expression; I-kappa B Kinase; Immunoblotting; Immunohistochemistry; Interleukin-1beta; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Matrix Metalloproteinase 9; Microscopy, Fluorescence; Rabbits; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spectrophotometry; Thiophenes | 2008 |
Investigation of nuclear factor-κB inhibitors and interleukin-10 as regulators of inflammatory signalling in human adipocytes.
Topics: Adipocytes; Amides; Cells, Cultured; Chemokine CCL2; Humans; Inflammation; Interleukin-10; Interleukin-6; NF-kappa B; Obesity; Receptors, Interleukin-10; STAT3 Transcription Factor; Thiophenes; Toll-Like Receptor 4; Transgenes | 2010 |
IKK-2 inhibitor TPCA-1 represses nasal epithelial inflammation in vitro.
Topics: Adult; Aged; Amides; Chemokine CXCL1; Female; Humans; Immunohistochemistry; In Vitro Techniques; Interleukin-8; Male; Middle Aged; Nasal Mucosa; Nasal Polyps; NF-kappa B; Thiophenes | 2011 |
Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Catalytic Domain; Cell Line, Tumor; Collagen; Crystallography, X-Ray; Drug Combinations; Extracellular Matrix; Humans; Inhibitory Concentration 50; Laminin; Models, Molecular; Myotonin-Protein Kinase; Neoplasm Invasiveness; Protein Kinase Inhibitors; Protein Multimerization; Protein-Tyrosine Kinases; Proteoglycans; Pyridines; rho-Associated Kinases; Thiophenes | 2011 |
Inhibition of type I interferon-mediated antiviral action in human glioma cells by the IKK inhibitors BMS-345541 and TPCA-1.
Topics: Amides; Antiviral Agents; Cell Line, Tumor; Cell Proliferation; Cytopathogenic Effect, Viral; Encephalomyocarditis virus; Enzyme Activation; Gene Expression Regulation, Neoplastic; Glioma; Humans; I-kappa B Kinase; Imidazoles; Interferon Type I; Interleukin-8; NF-kappa B; Quinoxalines; Thiophenes; Vesicular stomatitis Indiana virus | 2012 |
Synthesis, chemical reactivity as Michael acceptors, and biological potency of monocyclic cyanoenones, novel and highly potent anti-inflammatory and cytoprotective agents.
Topics: Alkynes; Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Apoptosis; Cell Line; Cell Line, Tumor; Cytoprotection; I-kappa B Kinase; Interleukin-1beta; Lipopolysaccharides; Macrophages; Mice; NAD(P)H Dehydrogenase (Quinone); Nitric Oxide; Nitriles; Oleanolic Acid; Phenanthrenes; Thiophenes; Tumor Necrosis Factor-alpha | 2012 |
NF-κB signaling is activated and confers resistance to apoptosis in three-dimensionally cultured EGFR-mutant lung adenocarcinoma cells.
Topics: Acrylamides; Adenocarcinoma; Adenocarcinoma of Lung; Amides; Apoptosis; Cell Adhesion; Cell Culture Techniques; Cell Line, Tumor; Drug Resistance, Neoplasm; ErbB Receptors; Extracellular Matrix; Humans; I-kappa B Kinase; Lung Neoplasms; Mutation; NF-kappa B; Protein Kinase Inhibitors; Pyrimidines; Thiophenes | 2012 |
Cigarette smoke induced airway inflammation is independent of NF-κB signalling.
Topics: Amides; Animals; Cells, Cultured; Disease Models, Animal; Epithelial Cells; Gene Expression; Humans; I-kappa B Kinase; Immunohistochemistry; Inflammation; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Nicotiana; Pulmonary Disease, Chronic Obstructive; Respiratory Tract Diseases; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Smoke; Smoking; Thiophenes; Time Factors; Transcription Factor RelA | 2013 |
The IKK inhibitor Bay 11-7082 induces cell death independent from inhibition of activation of NFκB transcription factors.
Topics: Amides; Apoptosis; Blotting, Western; Cell Line; Cell Survival; Cyclopentanes; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; I-kappa B Kinase; Microscopy, Fluorescence; Multiple Myeloma; NF-kappa B; Nitriles; Pyrimidines; RNA, Small Interfering; Signal Transduction; Sulfones; Thiophenes | 2013 |
TPCA-1 is a direct dual inhibitor of STAT3 and NF-κB and regresses mutant EGFR-associated human non-small cell lung cancers.
Topics: Amides; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Drug Synergism; ErbB Receptors; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; I-kappa B Proteins; Mutation; NF-kappa B; Quinazolines; Signal Transduction; STAT3 Transcription Factor; Thiophenes | 2014 |
Effects of cytokine-suppressive anti-inflammatory drugs on inflammatory activation in ex vivo human and ovine fetal membranes.
Topics: Acetylcysteine; Amides; Animals; Anti-Inflammatory Agents; Cell-Penetrating Peptides; Cells, Cultured; Cytokines; Dinoprostone; Extraembryonic Membranes; Female; Humans; Imidazoles; Inflammation; Pregnancy; Pyrimidines; Sheep; Thiophenes | 2014 |
Iron overload-modulated nuclear factor kappa-B activation in human endometrial stromal cells as a mechanism postulated in endometriosis pathogenesis.
Topics: Adult; Amides; Cells, Cultured; Endometriosis; Endometrium; Female; Ferric Compounds; Humans; Iron Overload; NF-kappa B; Stromal Cells; Thiophenes | 2015 |
IKK2 inhibition using TPCA-1-loaded PLGA microparticles attenuates laser-induced choroidal neovascularization and macrophage recruitment.
Topics: Amides; Animals; Choroidal Neovascularization; Disease Models, Animal; Drug Carriers; Female; I-kappa B Kinase; Lactic Acid; Macrophages; Male; Mice; Mice, Inbred C57BL; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Protein Kinase Inhibitors; Thiophenes | 2015 |
Breaking resistance of pancreatic cancer cells to an attenuated vesicular stomatitis virus through a novel activity of IKK inhibitor TPCA-1.
Topics: Amides; Cell Line, Tumor; Cytopathogenic Effect, Viral; Humans; I-kappa B Kinase; Interferon Type I; Janus Kinases; Myxovirus Resistance Proteins; Nitriles; Oncolytic Viruses; Pancreatic Neoplasms; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Sendai virus; Signal Transduction; STAT Transcription Factors; Thiophenes; Vesicular stomatitis Indiana virus; Virus Replication | 2015 |
Cell membrane-formed nanovesicles for disease-targeted delivery.
Topics: Amides; Animals; Cell Line; Cell Membrane; Drug Delivery Systems; Humans; Inflammation; Intercellular Adhesion Molecule-1; Mice; Nanoparticles; NF-kappa B; Pneumonia; Signal Transduction; Thiophenes; Vascular Diseases; Venules | 2016 |
Pathophysiology of Endometriosis: Role of High Mobility Group Box-1 and Toll-Like Receptor 4 Developing Inflammation in Endometrium.
Topics: Amides; Case-Control Studies; Cell Death; Cell Proliferation; Endometriosis; Endometrium; Epithelial Cells; Female; Gene Expression Regulation; HMGB1 Protein; Humans; Hysterectomy; Interleukin-6; Leiomyoma; NF-kappa B; Primary Cell Culture; Recombinant Proteins; Retrospective Studies; Signal Transduction; Stromal Cells; Thiophenes; Toll-Like Receptor 4 | 2016 |
STAT1 and NF-κB Inhibitors Diminish Basal Interferon-Stimulated Gene Expression and Improve the Productive Infection of Oncolytic HSV in MPNST Cells.
Topics: Amides; Animals; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Interferons; Mice; Nerve Sheath Neoplasms; NF-kappa B; Nitriles; Oncolytic Virotherapy; Pyrazoles; Pyrimidines; Signal Transduction; Simplexvirus; STAT1 Transcription Factor; Thiophenes; Virus Replication | 2016 |
Controlled Inhibition of the Mesenchymal Stromal Cell Pro-inflammatory Secretome via Microparticle Engineering.
Topics: Amides; Animals; Bone Marrow Cells; Cell Differentiation; Chemical Engineering; Coculture Techniques; Culture Media, Conditioned; Delayed-Action Preparations; Drug Carriers; Drug Compounding; Fibroblasts; Gene Expression; Humans; Inflammation; Lactic Acid; Mesenchymal Stem Cells; Mice; Models, Biological; Monocytes; NF-kappa B; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Primary Cell Culture; Thiophenes; Tumor Necrosis Factor-alpha | 2016 |
Novel biomarkers of resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus.
Topics: Adaptor Proteins, Signal Transducing; Amides; Apoptosis Regulatory Proteins; Biomarkers, Tumor; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; DNA Mutational Analysis; Down-Regulation; Gene Expression; Gene Expression Profiling; GTP-Binding Proteins; Humans; I-kappa B Kinase; Interferon Type I; Intracellular Signaling Peptides and Proteins; Janus Kinase 1; Janus Kinase 2; Mutation; Myxovirus Resistance Proteins; Neoplasm Proteins; Nitriles; Oncolytic Virotherapy; Oncolytic Viruses; Pancreatic Neoplasms; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; RNA Interference; RNA, Small Interfering; Thiophenes; Transcriptome; Vesiculovirus; Virus Replication | 2016 |
Preclinical evaluation of drugs to block inflammation-driven preterm birth.
Topics: Adolescent; Adult; Amides; Amnion; Bacterial Infections; Cells, Cultured; Chorioamnionitis; Cyclooxygenase 2; Cytokines; Female; Humans; I-kappa B Kinase; Inflammation Mediators; MAP Kinase Kinase Kinases; Pregnancy; Premature Birth; Thiophenes; Young Adult; Zearalenone | 2017 |
Activation of signal transducer and activator of transcription 3 (STAT3) signaling in EGFR mutant non-small-cell lung cancer (NSCLC).
Topics: Afatinib; Amides; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; ErbB Receptors; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Models, Biological; Mutation; Protein Kinase Inhibitors; Quinazolines; Signal Transduction; STAT3 Transcription Factor; Thiophenes | 2017 |
A high-throughput chemical screen identifies novel inhibitors and enhancers of anti-inflammatory functions of the glucocorticoid receptor.
Topics: A549 Cells; Amides; Anti-Inflammatory Agents; Camptothecin; Cell Line; Dexamethasone; Drug Evaluation, Preclinical; Drug Repositioning; Drug Synergism; Gene Expression Regulation; Glucocorticoids; Glycogen Synthase Kinase 3 beta; High-Throughput Screening Assays; Humans; NF-kappa B; Protein Kinase Inhibitors; Receptors, Glucocorticoid; Signal Transduction; Small Molecule Libraries; Thiophenes | 2017 |
Tofacitinib and TPCA-1 exert chondroprotective effects on extracellular matrix turnover in bovine articular cartilage ex vivo.
Topics: Amides; Animals; Cartilage, Articular; Cattle; Chondrocytes; Collagen Type II; Extracellular Matrix Proteins; Imidazoles; Osteoarthritis; Oxazines; Piperidines; Proteoglycans; Pyridines; Pyrimidines; Pyrroles; Thiophenes | 2019 |
Bioresponsive Nanoparticles Targeted to Infectious Microenvironments for Sepsis Management.
Topics: Amides; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Bacterial Proteins; Ciprofloxacin; Disease Models, Animal; Drug Delivery Systems; Drug Design; Human Umbilical Vein Endothelial Cells; Humans; Hydrogen-Ion Concentration; Lung Diseases; Mice; Micelles; Nanoparticles; Peritonitis; Polymers; Proof of Concept Study; Sepsis; Thiophenes | 2018 |
Anti-inflammatory role of TPCA-1 encapsulated nanosomes in porcine chondrocytes against TNF-α stimulation.
Topics: Amides; Animals; Anti-Inflammatory Agents; Basic Helix-Loop-Helix Transcription Factors; Chondrocytes; Collagen Type II; Down-Regulation; Drug Delivery Systems; Gene Expression; Inflammation; Matrix Metalloproteinase 13; Osteoarthritis; Signal Transduction; Swine; Thiophenes; Tumor Necrosis Factor-alpha | 2019 |
The Selection of NFκB Inhibitors to Block Inflammation and Induce Sensitisation to FasL-Induced Apoptosis in HNSCC Cell Lines Is Critical for Their Use as a Prospective Cancer Therapy.
Topics: Amides; Anti-Inflammatory Agents; Cell Line, Tumor; Cell Proliferation; Cyclopentanes; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drug Synergism; Fas Ligand Protein; Head and Neck Neoplasms; Humans; Hydrocortisone; Interleukin-8; NF-kappa B; Phenyl Ethers; Pyrimidines; Quinazolines; Signal Transduction; Squamous Cell Carcinoma of Head and Neck; Thiophenes; Tumor Necrosis Factor-alpha | 2019 |
pH-Responsive Nanoparticles Targeted to Lungs for Improved Therapy of Acute Lung Inflammation/Injury.
Topics: Acute Lung Injury; Amides; Animals; Antibodies, Anti-Idiotypic; Bacterial Infections; Drug Carriers; Humans; Hydrogen-Ion Concentration; Intercellular Adhesion Molecule-1; Lung; Mice; Nanoparticles; Pneumonia; Polyethylene Glycols; Rats; Respiratory Distress Syndrome; Thiophenes | 2019 |
Eomesodermin promotes interaction of RelA and NFATc2 with the Ifng promoter and multiple conserved noncoding sequences across the Ifng locus in mouse lymphoma BW5147 cells.
Topics: Amides; Animals; Cell Line, Tumor; Conserved Sequence; Gene Expression Regulation, Neoplastic; Genetic Loci; Interferon-gamma; Lymphoma; Mice; NFATC Transcription Factors; Promoter Regions, Genetic; Protein Kinase Inhibitors; STAT3 Transcription Factor; T-Box Domain Proteins; Thiophenes; Transcription Factor RelA | 2020 |
Sustained Release of TPCA-1 from Silk Fibroin Hydrogels Preserves Keratocyte Phenotype and Promotes Corneal Regeneration by Inhibiting Interleukin-1β Signaling.
Topics: Amides; Animals; Delayed-Action Preparations; Fibroins; Humans; Hydrogels; Interleukin-1beta; Mice; Phenotype; Thiophenes | 2020 |
Targeted and Combined TPCA-1-Gold Nanocage Therapy for In Vivo Treatment of Inflammatory Arthritis.
Topics: Amides; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Gold; Hyaluronic Acid; Male; Metal Nanoparticles; Mice; Thiophenes | 2020 |
Continuous NF-κB pathway inhibition promotes expansion of human phenotypical hematopoietic stem/progenitor cells through metabolism regulation.
Topics: Amides; Antigens, CD34; Cell Proliferation; Cell Respiration; Cells, Cultured; Energy Metabolism; Glycolysis; Hematopoietic Stem Cells; Humans; I-kappa B Proteins; Immunophenotyping; Mitochondria; NF-kappa B; Phenotype; Signal Transduction; Thiophenes | 2021 |
Pharmacological inhibition of IKKβ dampens NLRP3 inflammasome activation after priming in the human myeloid cell line THP-1.
Topics: Amides; Caspase 1; Humans; I-kappa B Kinase; Immunity, Innate; Inflammasomes; Interleukin-1beta; NF-kappa B; Nigericin; NLR Family, Pyrin Domain-Containing 3 Protein; Protein Kinase Inhibitors; Thiophenes; THP-1 Cells | 2021 |
IκB kinase promotes Nrf2 ubiquitination and degradation by phosphorylating cylindromatosis, aggravating oxidative stress injury in obesity-related nephropathy.
Topics: Amides; Animals; Cell Line; Deubiquitinating Enzyme CYLD; Humans; I-kappa B Kinase; Kidney; Kidney Diseases; Lipid Metabolism; Lipoproteins, LDL; Male; Mice, Inbred C57BL; NF-E2-Related Factor 2; Obesity; Oxidative Stress; Oxidoreductases; Phosphorylation; Protein Kinase Inhibitors; Reactive Oxygen Species; Thiophenes; Ubiquitination | 2021 |
Small Molecule Inhibitors Targeting Nuclear Factor κB Activation Markedly Reduce Expression of Interleukin-2, but Not Interferon-γ, Induced by Phorbol Esters and Calcium Ionophores.
Topics: Amides; Animals; Calcium Ionophores; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Interferon-gamma; Interleukin-2; Mice; NF-kappa B; Piperidines; Primary Cell Culture; Promoter Regions, Genetic; Pyrrolidines; Small Molecule Libraries; T-Box Domain Proteins; Tetradecanoylphorbol Acetate; Thiophenes | 2021 |
Transcriptome‑based drug repositioning identifies TPCA‑1 as a potential selective inhibitor of esophagus squamous carcinoma cell viability.
Topics: Amides; Cell Line, Tumor; Cell Survival; Drug Repositioning; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Gene Expression Regulation, Neoplastic; Humans; NF-kappa B; Thiophenes; Transcriptome | 2022 |
Keratocyte Differentiation Is Regulated by NF-κB and TGFβ Signaling Crosstalk.
Topics: Amides; Cell Differentiation; Cells, Cultured; Lumican; NF-kappa B; RNA, Messenger; Signal Transduction; Thiophenes; Transforming Growth Factor beta; Transforming Growth Factors | 2022 |