Compounds > thiophenes
Page last updated: 2024-08-18

thiophenes and 1843u89

thiophenes has been researched along with 1843u89 in 16 studies

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's13 (81.25)18.2507
2000's3 (18.75)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Erlichman, C; Mandelbaum, S; Mitrovski, B; Pressacco, J1
Calvert, AH; Jackman, AL1
Bertino, JR; Ercikan, E; Gorlick, R; Longo, GS; Tong, WP1
Jansen, G; Peters, GJ; Pinedo, HM; Telleman, F; van der Wilt, CL; van Triest, B1
Dolnick, BJ; Lu, K; Rustum, YM; Yin, MB1
Takimoto, CH1
Banerjee, D; Bertino, JR; Ercikan-Abali, EA; Liu-Chen, X; Maley, F; Tong, Y; Zhao, SC1
Bertino, JR; Li, WW; Tong, WP1
Assaraf, YG; Borst, P; Broxterman, HJ; Hooijberg, JH; Jansen, G; Kool, M; Noordhuis, P; Peters, GJ; Pinedo, HM; Scheper, RJ1
Jansen, G; Peters, GJ; Pinedo, HM; Smid, K; Smitskamp-Wilms, E1
Newell, DR1
Danenberg, PV; Malli, H; Swenson, S1
Kuiper, CM; Peters, GJ; van der Wilt, CL1
Aherne, GW; Brunton, L; Jackman, AL; Monaghan, P; Titley, J; Valenti, M; Welsh, SJ1
Callender, MA; Chu, E; Farrell, MP; Schmitz, JC1
Fukushima, M; Hoogeland, MF; Peters, GJ; Temmink, OH1

Reviews

5 review(s) available for thiophenes and 1843u89

ArticleYear
Folate-based thymidylate synthase inhibitors as anticancer drugs.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1995, Volume: 6, Issue:9

    Topics: Antineoplastic Agents; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Indoles; Isoindoles; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase

1995
Antifolates in clinical development.
    Seminars in oncology, 1997, Volume: 24, Issue:5 Suppl 18

    Topics: Aminopterin; Animals; Antimetabolites, Antineoplastic; Clinical Trials as Topic; Drug Design; Enzyme Inhibitors; Folic Acid Antagonists; Glutamates; Guanine; Humans; Indoles; Isoindoles; Pemetrexed; Pyrimidines; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase

1997
Clinical pharmacokinetics of antitumor antifolates.
    Seminars in oncology, 1999, Volume: 26, Issue:2 Suppl 6

    Topics: Antimetabolites, Antineoplastic; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Humans; Indoles; Isoindoles; Methotrexate; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase

1999
Thymidylate synthase inhibitors.
    Seminars in oncology, 1999, Volume: 26, Issue:6

    Topics: Animals; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Indoles; Isoindoles; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase

1999
Thymidylate synthase inhibitors as anticancer agents: from bench to bedside.
    Cancer chemotherapy and pharmacology, 2003, Volume: 52 Suppl 1

    Topics: Antineoplastic Agents; Enzyme Inhibitors; Humans; Indoles; Isoindoles; Neoplasms; Quinazolines; Randomized Controlled Trials as Topic; Thiophenes; Thymidylate Synthase

2003

Other Studies

11 other study(ies) available for thiophenes and 1843u89

ArticleYear
Biochemical effects of folate-based inhibitors of thymidylate synthase in MGH-U1 cells.
    Cancer chemotherapy and pharmacology, 1994, Volume: 35, Issue:2

    Topics: Cell Survival; Deoxyuracil Nucleotides; Deoxyuridine; Folic Acid; Folic Acid Antagonists; Glutamates; Humans; In Vitro Techniques; Indoles; Isoindoles; Quinazolines; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured; Urinary Bladder Neoplasms

1994
Disparate affinities of antifolates for folylpolyglutamate synthetase from human leukemia cells.
    Blood, 1997, Aug-01, Volume: 90, Issue:3

    Topics: Acute Disease; Antimetabolites, Antineoplastic; Drug Resistance, Neoplasm; Enzyme Inhibitors; Folic Acid Antagonists; HL-60 Cells; Humans; Indoles; Isoindoles; Kinetics; Leukemia, Myeloid; Methotrexate; Neoplasm Proteins; Organ Specificity; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured

1997
Cross-resistance to antifolates in multidrug resistant cell lines with P-glycoprotein or multidrug resistance protein expression.
    Biochemical pharmacology, 1997, Jun-15, Volume: 53, Issue:12

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Cell Division; Drug Resistance, Multiple; Fluorodeoxyuridylate; Fluorouracil; Folic Acid Antagonists; Gene Expression Regulation; Humans; Indoles; Isoindoles; Methotrexate; Peptide Synthases; Polymerase Chain Reaction; Quinazolines; RNA, Messenger; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured

1997
Recent advances in the study of rTS proteins. rTS expression during growth and in response to thymidylate synthase inhibitors in human tumor cells.
    Advances in enzyme regulation, 1997, Volume: 37

    Topics: Blotting, Western; Cell Division; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Floxuridine; Folic Acid Antagonists; Gene Expression Regulation, Neoplastic; Humans; Hydro-Lyases; Indoles; Isoindoles; Protein Biosynthesis; Proteins; Quinazolines; Racemases and Epimerases; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured

1997
Probing the folate-binding site of human thymidylate synthase by site-directed mutagenesis. Generation of mutants that confer resistance to raltitrexed, Thymitaq, and BW1843U89.
    The Journal of biological chemistry, 1998, Nov-20, Volume: 273, Issue:47

    Topics: Animals; Antimetabolites, Antineoplastic; Binding Sites; Bone Marrow Cells; Drug Resistance; Folic Acid; Folic Acid Antagonists; Granulocytes; Humans; Indoles; Isoindoles; Isoleucine; Kinetics; Macrophages; Mice; Models, Molecular; Mutagenesis, Site-Directed; Quinazolines; Recombinant Proteins; Stem Cells; Thiophenes; Thymidylate Synthase

1998
Antitumor activity of antifolate inhibitors of thymidylate and purine synthesis in human soft tissue sarcoma cell lines with intrinsic resistance to methotrexate.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1995, Volume: 1, Issue:6

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Biological Transport; Biotransformation; Cell Division; Cell Survival; Drug Resistance, Neoplasm; Folic Acid Antagonists; Humans; Indoles; Isoindoles; Kinetics; Methotrexate; Purines; Quinazolines; Sarcoma; Tetrahydrofolates; Thiophenes; Thymidine Monophosphate; Tumor Cells, Cultured

1995
Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2.
    Cancer research, 1999, Jun-01, Volume: 59, Issue:11

    Topics: Adenosine Triphosphate; Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Folic Acid Antagonists; Glutamates; Humans; Indoles; Isoindoles; Methotrexate; Ovarian Neoplasms; Quinazolines; Thiophenes; Transfection; Tumor Cells, Cultured

1999
Determinants of activity of the antifolate thymidylate synthase inhibitors Tomudex (ZD1694) and GW1843U89 against mono- and multilayered colon cancer cell lines under folate-restricted conditions.
    Cancer research, 1999, Nov-01, Volume: 59, Issue:21

    Topics: Blotting, Western; Cell Cycle; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Humans; Immunohistochemistry; Indoles; Inhibitory Concentration 50; Isoindoles; Methotrexate; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured

1999
Combination studies of antifolates with 5-fluorouracil in colon cancer cell lines.
    Oncology research, 1999, Volume: 11, Issue:8

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Colonic Neoplasms; DNA Damage; Fluorouracil; Folic Acid Antagonists; Glutamates; Guanine; Humans; Indoles; Isoindoles; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured

1999
Comparison of thymidylate synthase (TS) protein up-regulation after exposure to TS inhibitors in normal and tumor cell lines and tissues.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:6

    Topics: Analysis of Variance; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Blotting, Western; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Fibroblasts; Flow Cytometry; Fluorouracil; Glutamates; Guanine; Humans; Indoles; Inhibitory Concentration 50; Isoindoles; Mice; Mice, Inbred DBA; Microscopy, Confocal; Neoplasm Transplantation; Pemetrexed; Quinazolines; Thiophenes; Thymidylate Synthase; Time Factors; Tumor Cells, Cultured; Up-Regulation

2000
Low folate conditions may enhance the interaction of trifluorothymidine with antifolates in colon cancer cells.
    Cancer chemotherapy and pharmacology, 2006, Volume: 57, Issue:2

    Topics: Antimetabolites; Colonic Neoplasms; DNA Damage; Drug Interactions; Folic Acid; Folic Acid Antagonists; Homeostasis; Humans; Indoles; Isoindoles; Quinazolines; Thiophenes; Trifluridine; Tumor Cells, Cultured

2006