thiophenes has been researched along with 1,2-dithiol-3-thione in 98 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (2.04) | 18.7374 |
| 1990's | 21 (21.43) | 18.2507 |
| 2000's | 47 (47.96) | 29.6817 |
| 2010's | 26 (26.53) | 24.3611 |
| 2020's | 2 (2.04) | 2.80 |
| Authors | Studies |
|---|---|
| Groopman, JD; Kensler, TW; Roebuck, BD | 1 |
| Curphey, TJ; Eaton, DL; Groopman, JD; Kensler, TW; Roebuck, BD | 1 |
| Rembish, SJ; Trush, MA; Twerdok, LE | 2 |
| Gordon, GB; Prochaska, HJ; Yang, LY | 1 |
| DeMatos, P; Egner, PA; Groopman, JD; Kensler, TW; Love-Hunt, A | 1 |
| Dolan, PM; Egner, PA; Groopman, JD; Kensler, TW; Roebuck, BD | 1 |
| Bueding, E; De Long, MJ; Dolan, P; Santamaria, AB | 1 |
| Lafuente, A; Li, Y; Trush, MA | 1 |
| Li, Y; Trush, MA; Zhu, H | 1 |
| Coles, B; Gilmore, KS; Guengerich, FP; Harris, J; Harris, TM; Kensler, TW; Ketterer, B; Meyer, DJ; Raney, K | 1 |
| Fardel, O; Gilmore, KS; Guillouzo, A; Kensler, TW; Ketterer, B; Langouet, S; Meunier, B; Meyer, DJ; Morel, F; Tu, CP | 1 |
| Coles, B; Gilmore, KS; Harris, JM; Kensler, TW; Ketterer, B; Meyer, DJ | 1 |
| Bona, M; Boudeville, P; Burgot, JL; Christen, MO; Zekri, O | 1 |
| Begleiter, A; Curphey, TJ; Leith, MK | 1 |
| Bona, M; Boudeville, P; Burgot, JL | 1 |
| Kensler, TW; Kuppusamy, P; Primiano, T; Sutter, TR; Zweier, JL | 1 |
| Gastel, JA; Kensler, TW; Primiano, T; Sutter, TR | 1 |
| Gates, KS; Kim, W | 1 |
| Li, Y; Rembish, SJ; Trush, MA; Twerdok, LE; Zhu, H | 1 |
| Begleiter, A; Curphey, TJ; Doherty, GP; Leith, MK; Wang, X | 1 |
| Camoirano, A; Cartiglia, C; De Flora, S; Grubbs, CJ; Izzotti, A; Kelloff, GJ; Lubet, RA | 1 |
| Kensler, TW; Primiano, T; Sutter, TR; Trush, MA | 1 |
| Furge, LL; Guengerich, FP; Guillouzo, A; Kerriguy, N; Langouët, S; Nakamura, K | 1 |
| Guyton, KZ; Kensler, TW; Otieno, MA | 1 |
| Arif, JM; Gupta, RC; Smith, WA | 1 |
| Begleiterabc, A; Digbya, TJ; Doherty, GP; Leith, MK; Pan, S | 1 |
| Aliaga, C; Cohen, LA; Lubet, R; Pittman, B; Zhao, Z | 1 |
| Itoh, K; Kensler, TW; Kwak, MK; Sutter, TR; Yamamoto, M | 1 |
| Freeman, JW; Gupta, RC; Smith, WA | 1 |
| Dolan, PM; Egner, PA; Groopman, JD; Itoh, K; Kensler, TW; Kwak, MK; Ramos-Gomez, M; Yamamoto, M | 1 |
| de Boer, JG; Glickman, BW; Stuart, GR; Yang, H | 1 |
| Cao, Z; Li, Y | 3 |
| Itoh, K; Kensler, TW; Kwak, MK; Yamamoto, M | 1 |
| Li, Y; Peng, X | 1 |
| Chan, JY; Pietsch, EC; Torti, FM; Torti, SV | 1 |
| Cao, Z; Hardej, D; Li, Y; Trombetta, LD; Trush, MA | 1 |
| Cao, Z; Hardej, D; Li, Y; Trombetta, LD | 1 |
| Greenlaw, JL; Kensler, TW; Kwak, MK; Wakabayashi, N; Yamamoto, M | 1 |
| Cao, Z; Hallur, S; Li, Y; Peng, X; Qiu, HZ | 1 |
| Desai, D; El-Bayoumy, K; Guttenplan, JB; Khmelnitsky, M; Kosinska, W; Spratt, TE | 1 |
| Munday, CM; Munday, R | 1 |
| Aimar, ML; de Rossi, RH; Enriz, RD; Giannini, FA; Gomez, R; Juarez, A; Sortino, M; Sturniollo, A; Zacchino, S | 1 |
| Desai, UR; He, X; Kellogg, GE; Reeve, AM; Reynolds, KA | 1 |
| Chun, JA; Furge, LL; Haab, BB; Haddad, R; Klenow, S; Konwinski, RR; Larson, SC | 1 |
| Itoh, K; Li, Y; Yamamoto, M; Zhu, H; Zweier, JL | 1 |
| Burgot, G; Burgot, JL; Gargadennec, S; Mannhold, R; Rekker, RF | 1 |
| Gao, X; Goldring, MB; Healy, ZR; Kensler, TW; Konstantopoulos, K; Lee, NH; Talalay, P | 1 |
| Huang, Y; Kensler, TW; Lubet, R; Sutter, TR; Yan, J | 1 |
| Bodreddigari, S; Huang, Y; Karuri, AR; Kensler, TW; Roebuck, BD; Sutter, CH; Sutter, TR | 1 |
| Li, J; Munday, CM; Munday, R; Zhang, Y | 1 |
| Burton, NC; Guilarte, TR; Kensler, TW | 1 |
| Cao, Z; Li, Y; Trush, MA; Zhang, L; Zhu, H | 1 |
| Andringa, G; Drukarch, B; Halfhide, L; Jongenelen, CA | 1 |
| Li, Y; Trush, MA; Zhang, L; Zhu, H | 1 |
| Cho, JM; Kensler, TW; Kim, JA; Kwak, MK; Manandhar, S | 1 |
| Jia, Z; Li, Y; Misra, HP; Trush, MA; Zhu, H | 1 |
| Jia, Z; Li, Y; Misra, HP; Zhu, H | 2 |
| Cao, Z; Jia, Z; Li, Y; Misra, BR; Misra, HP; Trush, MA; Yamamoto, M; Zhang, L; Zhu, H | 1 |
| Cho, JM; Kwak, MK; Lee, HR; Park, HM; Shim, GS | 1 |
| Chen, SY; Dong, J; Sulik, KK | 1 |
| Baxter, P; Hardingham, GE; Hayes, JD; Higgins, LG; Léveillé, F; Papadia, S; Soriano, FX; Varley, J | 1 |
| Jia, Z; Li, Y; Misra, BR; Misra, HP; Zhu, H | 1 |
| George, EO; Goodwin, SB; Jin, VX; Kensler, TW; Phan, V; Rahman, M; Roebuck, BD; Sutter, CH; Sutter, TR; Tran, QT; Xu, L | 1 |
| Gabrielson, KL; Jia, Z; Li, Y; Misra, HP; Santo, A; Zhou, K; Zhu, H | 1 |
| Grubbs, CJ; Lubet, RA; Wang, Y; Yao, R; You, M | 1 |
| Fishbein, JC; Holland, R; Kensler, TW; Navamal, M; Velayutham, M; Zweier, JL | 1 |
| Giustarini, D; Perrino, E; Rossi, R; Tazzari, V | 1 |
| Babu, J; Munday, CM; Munday, R; Paonessa, JD; Wilkins, AL; Zhang, Y | 1 |
| Bhattacharyya, S; Gates, KS; Seiner, DR; Zhou, H | 1 |
| Chen, SY; Dong, J; Yan, D | 1 |
| Kim, SG; Koo, JH; Lee, CG; Lee, WH | 1 |
| Hansen, JM; Harris, C | 1 |
| Burgess, JR; Pazdro, R | 1 |
| Cabrera, M; Cerecetto, H; Couto, M; Echeverría, GA; González, M; Piro, OE | 1 |
| Ding, QL; Guan, QH; Hu, DH; Yan, SM; Zhang, X; Zhang, YT; Zheng, HL | 1 |
| Bovet, C; Erzinger, MM; Sturla, SJ; Uzozie, A | 1 |
| Pacheco, A; Xian, M; Zhao, Y | 1 |
| Agarwal, A; Arosio, P; Balla, G; Balla, J; Balogh, E; Bányai, E; Becs, Á; Becs, G; Eaton, JW; Jeney, V; Kovács, KÉ; Nyitrai, M; Poli, M; Zarjou, A | 1 |
| Brown, DA; Chang, FL; Kuo, PC; Scofield, BA; Wang, PY; Yen, JH; Yu, IC | 1 |
| Cao, C; Gong, YQ; Jiang, Q; Li, KR; Li, XM; Yang, H; Yang, SQ; Yao, J; Zhao, YX | 1 |
| Kim, SG; Lee, JM; Lee, YH; Lee, YS | 1 |
| Bao, K; Li, M; Lu, G; Qi, H; Shen, Q; Wang, Z; Wu, Y; Zhang, W | 1 |
| Afzal, CM; Hu, J; Li, G; Ma, R; Shen, W; Wang, L; Wang, M; Wang, X; Yao, Y | 1 |
| Brown, DA; Chang, FL; Curfman, ET; Kuo, PC; Paraiso, HC; Scofield, BA; Yen, JH; Yu, IC | 1 |
| Cao, W; Cui, Y; Guan, F; Huang, T; Li, D; Lv, P; Ma, S; Xing, Q; Yang, B; Yang, GL; Zhang, C | 1 |
| Brown, DA; Kuo, PC; Paraiso, HC; Scofield, BA; Wang, PY; Yen, JH; Yu, IC | 1 |
| Flage, B; Ghosh, S; Hazra, R; Ihunnah, CA; Ofori-Acquah, SF; Weidert, F | 1 |
| Bian, XL; Chen, ZZ; Shao, LH; Wang, QT; Xie, YD; Xu, YH | 1 |
| Burgess, JR; Stochelski, MA; Walters, M; Wilmanski, T | 1 |
| Agarwal, A; Arosio, P; Balla, G; Balla, J; Beke, L; Fürtös, I; Hendrik, Z; Méhes, G; Oros, M; Poli, M; Posta, N; Potor, L; Sikura, KÉ; Szerafin, T; Zarjou, A | 1 |
| Hansen, JM; Piorczynski, TB | 1 |
| Ali, R; Hameed, R; Nazir, A; Pal, HA; Verma, S | 1 |
| Hansen, JM; Harris, C; Lapehn, S; Piorczynski, TB | 1 |
| Bui, A; Li, YR; Santo, A; Zhu, H | 1 |
4 review(s) available for thiophenes and 1,2-dithiol-3-thione
| Article | Year |
|---|---|
Molecular dosimetry of aflatoxin DNA adducts in humans and experimental rat models.
Topics: Aflatoxins; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; China; DNA; Environmental Exposure; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; Rats; Thiones; Thiophenes | 1992 |
Analysis of target cell susceptibility as a basis for the development of a chemoprotective strategy against benzene-induced hematotoxicities.
Topics: Animals; Benzene; Bone Marrow; Bone Marrow Cells; Cytochrome P-450 CYP2E1; Drug Resistance; Glutathione; Humans; Hydroquinones; Liver; Mice; NAD(P)H Dehydrogenase (Quinone); Rats; Thiones; Thiophenes | 1996 |
Role of phase 2 enzyme induction in chemoprotection by dithiolethiones.
Topics: Aflatoxin B1; Animals; Antineoplastic Agents; Carcinogens; Chemoprevention; China; Controlled Clinical Trials as Topic; Enzyme Induction; Gene Expression; Glucuronosyltransferase; Glutathione Transferase; Humans; Inactivation, Metabolic; Liver Neoplasms; Pyrazines; Quinone Reductases; Thiones; Thiophenes | 2001 |
Medicinal Chemistry: Insights into the Development of Novel H2S Donors.
Topics: Chemistry, Pharmaceutical; Garlic; Hydrogen Sulfide; Morpholines; Organothiophosphorus Compounds; Sulfides; Thiones; Thiophenes | 2015 |
94 other study(ies) available for thiophenes and 1,2-dithiol-3-thione
| Article | Year |
|---|---|
Potent inhibition of aflatoxin-induced hepatic tumorigenesis by the monofunctional enzyme inducer 1,2-dithiole-3-thione.
Topics: Aflatoxin B1; Animals; Antineoplastic Agents; Enzyme Induction; gamma-Glutamyltransferase; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Pyrazines; Rats; Rats, Inbred F344; Thiones; Thiophenes | 1992 |
Induction of quinone reductase and glutathione in bone marrow cells by 1,2-dithiole-3-thione: effect on hydroquinone-induced cytotoxicity.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Dicumarol; Drug Synergism; Enzyme Induction; Fibroblasts; Glutathione; Glutathione Transferase; Hydrogen Peroxide; Hydroquinones; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Peroxidases; Quinone Reductases; Receptors, Aryl Hydrocarbon; Receptors, Drug; Thiones; Thiophenes; Time Factors | 1992 |
Induction of NAD(P)H:quinone reductase in human peripheral blood lymphocytes.
Topics: Adult; Aged; Cell Transformation, Viral; Cells, Cultured; Dimethyl Fumarate; Enzyme Induction; Female; Fumarates; Herpesvirus 4, Human; Humans; Lymphocyte Activation; Lymphocytes; Male; Middle Aged; Mitogens; NAD(P)H Dehydrogenase (Quinone); Sulfones; Thiones; Thiophenes | 1991 |
Molecular dosimetry of urinary aflatoxin-N7-guanine and serum aflatoxin-albumin adducts predicts chemoprotection by 1,2-dithiole-3-thione in rats.
Topics: Aflatoxin B1; Animals; Antineoplastic Agents; Biomarkers; DNA; Guanine; Liver Neoplasms, Experimental; Male; Protein Binding; Pyrazines; Rats; Rats, Inbred F344; Serum Albumin; Thiones; Thiophenes | 1992 |
Mechanism of protection against aflatoxin tumorigenicity in rats fed 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz) and related 1,2-dithiol-3-thiones and 1,2-dithiol-3-ones.
Topics: Aflatoxin B1; Aflatoxins; Animals; Antineoplastic Agents; Cytochrome P-450 Enzyme System; DNA; Enzyme Induction; gamma-Glutamyltransferase; Glutathione Transferase; Heterocyclic Compounds; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Pyrazines; Rats; Rats, Inbred F344; Structure-Activity Relationship; Thiones; Thiophenes | 1987 |
1,2-Dithiol-3-thione analogs: effects on NAD(P)H:quinone reductase and glutathione levels in murine hepatoma cells.
Topics: Animals; Antineoplastic Agents; Cell Line; Dose-Response Relationship, Drug; Enzyme Induction; Glutathione; Liver Neoplasms, Experimental; Mice; Mutation; Quinone Reductases; Structure-Activity Relationship; Thiones; Thiophenes | 1986 |
Characterization of quinone reductase, glutathione and glutathione S-transferase in human myeloid cell lines: induction by 1,2-dithiole-3-thione and effects on hydroquinone-induced cytotoxicity.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Buthionine Sulfoximine; Dicumarol; Drug Synergism; Enzyme Induction; Glutathione; Glutathione Transferase; Humans; Hydroquinones; Leukemia, Myeloid; Methionine Sulfoximine; Models, Chemical; NAD(P)H Dehydrogenase (Quinone); Peroxidase; Thiones; Thiophenes; Tumor Cells, Cultured | 1994 |
Characterization of benzo[a]pyrene quinone-induced toxicity to primary cultured bone marrow stromal cells from DBA/2 mice: potential role of mitochondrial dysfunction.
Topics: Adenosine Triphosphate; Anemia, Aplastic; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Benzo(a)pyrene; Benzopyrenes; Bone Marrow; Bone Marrow Cells; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Dicumarol; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione; Leukemia, Experimental; Male; Methionine Sulfoximine; Mice; Mice, Inbred DBA; Mitochondria; NAD(P)H Dehydrogenase (Quinone); Quinones; Stromal Cells; Superoxide Dismutase; Thiones; Thiophenes | 1995 |
Induction of rat liver GSH transferases by 1,2-dithiole-3-thione illustrates both anticarcinogenic and tumor-promoting properties.
Topics: Aflatoxin B1; Animals; Anticarcinogenic Agents; Carcinogens; Chromatography, Affinity; Chromatography, High Pressure Liquid; Cytosol; Enzyme Induction; Glutathione Transferase; Inactivation, Metabolic; Liver; Macromolecular Substances; Phenobarbital; Rats; Rats, Sprague-Dawley; Thiones; Thiophenes | 1993 |
Studies with 1,2-dithiole-3-thione as a chemoprotector of hydroquinone-induced toxicity to DBA/2-derived bone marrow stromal cells.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Dose-Response Relationship, Drug; Hydroquinones; Male; Mice; Mice, Inbred DBA; NAD(P)H Dehydrogenase (Quinone); Stromal Cells; Thiones; Thiophenes | 1993 |
Preferential increase of glutathione S-transferase class alpha transcripts in cultured human hepatocytes by phenobarbital, 3-methylcholanthrene, and dithiolethiones.
Topics: Cells, Cultured; Enzyme Induction; Gene Expression; Glutathione Transferase; Humans; Liver; Methylcholanthrene; Phenobarbital; Pyrazines; RNA, Messenger; Thiones; Thiophenes | 1993 |
Quantitation of tissue- and sex-specific induction of rat GSH transferase subunits by dietary 1,2-dithiole-3-thiones.
Topics: Animals; Antineoplastic Agents; Enzyme Induction; Female; Glutathione Transferase; Intestine, Small; Kidney; Lung; Male; Organ Specificity; Pyrazines; Rats; Rats, Sprague-Dawley; Sex Characteristics; Stomach; Thiones; Thiophenes | 1993 |
Water/n-octanol partition coefficients of 1,2-dithiole-3-thiones.
Topics: Antineoplastic Agents; Chromatography, High Pressure Liquid; Octanols; Solubility; Spectrophotometry, Ultraviolet; Thiones; Thiophenes | 1995 |
Induction of DT-diaphorase by 1,2-dithiole-3-thione and increase of antitumour activity of bioreductive agents.
Topics: Animals; Antineoplastic Agents; Aziridines; Biotransformation; Enzyme Induction; Indolequinones; Indoles; Lymphoma; Mice; Mice, Inbred DBA; Mitomycin; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction; Thiones; Thiophenes; Tumor Cells, Cultured | 1996 |
Correlations between n-octanol/water partition coefficients and RP-HPLC capacity factors of 1,2-dithiole-3-thiones and 1,2-dithiol-3-ones.
Topics: Antineoplastic Agents; Chromatography, High Pressure Liquid; Solubility; Thiones; Thiophenes | 1996 |
Induction of hepatic heme oxygenase-1 and ferritin in rats by cancer chemopreventive dithiolethiones.
Topics: Animals; Anticarcinogenic Agents; Cycloheximide; Enzyme Induction; Ferritins; Heme Oxygenase (Decyclizing); Iron; Isoenzymes; Liver; Male; Protein Synthesis Inhibitors; Rats; Rats, Inbred F344; RNA; Thiones; Thiophenes | 1996 |
Isolation of cDNAs representing dithiolethione-responsive genes.
Topics: Amino Acid Sequence; Animals; Anticarcinogenic Agents; DNA, Complementary; Gene Expression Regulation; Male; Molecular Sequence Data; Rats; Rats, Inbred F344; RNA, Messenger; Thiones; Thiophenes; Time Factors; Transcriptional Activation | 1996 |
Evidence for thiol-dependent production of oxygen radicals by 4-methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione (oltipraz) and 3H-1,2-dithiole-3-thione: possible relevance to the anticarcinogenic properties of 1,2-dithiole-3-thiones.
Topics: Anaerobiosis; Anticarcinogenic Agents; Buffers; Chelating Agents; Chemical Phenomena; Chemistry, Physical; DNA Damage; Electrophoresis, Polyacrylamide Gel; Free Radical Scavengers; Free Radicals; Plasmids; Pyrazines; Sulfhydryl Compounds; Thiones; Thiophenes | 1997 |
Induction of DT-diaphorase by 1,2-dithiole-3-thiones in human tumour and normal cells and effect on anti-tumour activity of bioreductive agents.
Topics: Antineoplastic Agents; Aziridines; Bone Marrow; Cell Survival; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Induction; Humans; Indolequinones; Indoles; Kidney; Lung; Mitomycin; NAD(P)H Dehydrogenase (Quinone); Thiones; Thiophenes; Tumor Cells, Cultured | 1998 |
Patterns of DNA adduct formation in liver and mammary epithelial cells of rats treated with 7,12-dimethylbenz(a)anthracene, and selective effects of chemopreventive agents.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Butylated Hydroxyanisole; Carcinogens; DNA Adducts; Epithelial Cells; Female; Glutathione; Liver; Mammary Glands, Animal; Rats; Rats, Sprague-Dawley; Thiones; Thiophenes | 1999 |
Induction of leukotriene B4 metabolism by cancer chemopreventive agents.
Topics: Alcohol Oxidoreductases; Animals; Antineoplastic Agents; Cytosol; Leukotriene B4; Male; Neoplasms, Experimental; Rats; Rats, Inbred F344; RNA, Messenger; Thiones; Thiophenes | 1999 |
Inhibition of human cytochrome P450 enzymes by 1,2-dithiole-3-thione, oltipraz and its derivatives, and sulforaphane.
Topics: Anticarcinogenic Agents; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Humans; Isothiocyanates; Pyrazines; Quinolines; Sulfoxides; Thiocyanates; Thiones; Thiophenes | 2000 |
Chemoprotective 3H-1,2-dithiole-3-thione induces antioxidant genes in vivo.
Topics: Animals; Antineoplastic Agents; Antioxidants; Catalase; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genes, Reporter; Glutamate-Cysteine Ligase; Immunoblotting; Male; Rats; Rats, Inbred F344; RNA, Messenger; Superoxide Dismutase; Thiones; Thiophenes; Transfection; Tumor Cells, Cultured | 2000 |
1,2-dithiole-3-thione and its structural analogue oltipraz are potent inhibitors of dibenz.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Benzopyrenes; Body Weight; Chromatography; DNA Adducts; Female; Liver; Lung; Mammary Glands, Animal; Pyrazines; Rats; Rats, Sprague-Dawley; Thiones; Thiophenes | 2001 |
Factors influencing the induction of DT-diaphorase activity by 1,2-dithiole-3-thione in human tumor cell lines.
Topics: Antineoplastic Agents; Blotting, Northern; Blotting, Western; Enzyme Induction; HL-60 Cells; Humans; Mutation; NAD(P)H Dehydrogenase (Quinone); RNA, Messenger; Thiones; Thiophenes; Transfection; Tumor Cells, Cultured | 2001 |
Feeding thiol-containing compounds, derived from vegetables, fails to inhibit N-methylnitrosourea-induced mammary tumorigenesis.
Topics: Administration, Oral; Animal Feed; Animals; Chemoprevention; Female; Incidence; Mammary Neoplasms, Experimental; Methyl Methanesulfonate; Plant Extracts; Rats; Rats, Sprague-Dawley; Thiones; Thiophenes; Vegetables | 2001 |
Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Antioxidants; Blotting, Northern; Blotting, Western; Cell Nucleus; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Genotype; Glutathione Transferase; Heterozygote; Homozygote; Immunoblotting; Liver; Mice; Mice, Inbred ICR; NF-E2-Related Factor 2; Oxygen; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Thiones; Thiophenes; Time Factors; Trans-Activators; Transcription, Genetic | 2001 |
Effect of chemopreventive agents on DNA adduction induced by the potent mammary carcinogen dibenzo[a,l]pyrene in the human breast cells MCF-7.
Topics: Anticarcinogenic Agents; Antimutagenic Agents; Antineoplastic Agents; Benzopyrenes; Breast; Breast Neoplasms; Carcinogens; Cell Line; Chemoprevention; Chlorophyllides; DNA Adducts; Dose-Response Relationship, Drug; Female; Humans; Pyrazines; Thiones; Thiophenes | 2001 |
Modulation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced mutation in the cecum and colon of big blue rats by conjugated linoleic acid and 1,2-dithiole-3-thione.
Topics: Animals; Animals, Genetically Modified; Anticarcinogenic Agents; Antimutagenic Agents; Bacterial Proteins; Cecum; Colon; Diet; Eating; Escherichia coli Proteins; Frameshift Mutation; Imidazoles; Lac Repressors; Linoleic Acid; Male; Mutagens; Rats; Rats, Inbred F344; Repressor Proteins; Thiones; Thiophenes; Weight Gain | 2001 |
Chemical induction of cellular antioxidants affords marked protection against oxidative injury in vascular smooth muscle cells.
Topics: Aldehydes; Animals; Antioxidants; Cadmium; Catalase; Cell Line; Cell Survival; Cytoplasm; Cytoprotection; Dose-Response Relationship, Drug; Glutathione; Muscle, Smooth, Vascular; Oxidative Stress; Rats; Superoxide Dismutase; Thiones; Thiophenes; Xanthine Oxidase | 2002 |
Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Cataract; Cell Line; Cell Nucleus; Cysteine Endopeptidases; DNA-Binding Proteins; Electrophoretic Mobility Shift Assay; Gene Expression Regulation; Genes, Reporter; Leupeptins; Mice; Multienzyme Complexes; Mutagenesis, Site-Directed; NF-E2-Related Factor 2; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Response Elements; RNA, Messenger; Thiones; Thiophenes; Trans-Activators; Transcription, Genetic | 2002 |
Induction of cellular glutathione-linked enzymes and catalase by the unique chemoprotective agent, 3H-1,2-dithiole-3-thione in rat cardiomyocytes affords protection against oxidative cell injury.
Topics: Animals; Antioxidants; Catalase; Cell Line; Cell Survival; Cytoprotection; Enzyme Induction; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Myocytes, Cardiac; Oxidative Stress; Rats; Reactive Oxygen Species; Thiones; Thiophenes | 2002 |
Nrf2 mediates the induction of ferritin H in response to xenobiotics and cancer chemopreventive dithiolethiones.
Topics: 3T3 Cells; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Base Sequence; beta-Naphthoflavone; Blotting, Northern; Cell Line; DNA-Binding Proteins; Enzyme Inhibitors; Ferritins; Gene Deletion; Genes, Reporter; Humans; Iron; Mice; Models, Biological; Models, Genetic; Molecular Sequence Data; NF-E2-Related Factor 2; Plasmids; Protein Binding; Protein Structure, Tertiary; Pyrazines; Response Elements; Thiones; Thiophenes; Time Factors; Trans-Activators; Transcription, Genetic; Transcriptional Activation; Tumor Cells, Cultured; Xenobiotics | 2003 |
Induction of cellular glutathione and glutathione S-transferase by 3H-1,2-dithiole-3-thione in rat aortic smooth muscle A10 cells: protection against acrolein-induced toxicity.
Topics: Acrolein; Analysis of Variance; Animals; Antioxidants; Aorta; Cells, Cultured; Dose-Response Relationship, Drug; Glutathione; Glutathione Transferase; Inactivation, Metabolic; Muscle, Smooth, Vascular; Probability; Rats; Rats, Sprague-Dawley; Thiones; Thiophenes | 2003 |
The role of chemically induced glutathione and glutathione S-transferase in protecting against 4-hydroxy-2-nonenal-mediated cytotoxicity in vascular smooth muscle cells.
Topics: Aldehydes; Animals; Antineoplastic Agents; Aorta; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Chemoprevention; Dose-Response Relationship, Drug; Enzyme Induction; Glutathione; Glutathione Transferase; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Rats; Sulfasalazine; Thiones; Thiophenes | 2003 |
Antioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling pathway.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antioxidants; Base Sequence; Carrier Proteins; Cysteine Endopeptidases; Cytoskeletal Proteins; DNA; DNA-Binding Proteins; Gene Expression; In Vitro Techniques; Kelch-Like ECH-Associated Protein 1; Liver; Mice; Mice, Knockout; Multienzyme Complexes; NF-E2-Related Factor 2; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Signal Transduction; Thiones; Thiophenes; Trans-Activators | 2003 |
Induction of endogenous glutathione by the chemoprotective agent, 3H-1,2-dithiole-3-thione, in human neuroblastoma SH-SY5Y cells affords protection against peroxynitrite-induced cytotoxicity.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance; Glutathione; Humans; Neuroblastoma; Peroxynitrous Acid; Thiones; Thiophenes | 2004 |
Effects of 3H-1,2-dithiole-3-thione, 1,4-phenylenebis(methylene)selenocyanate, and selenium-enriched yeast individually and in combination on benzo[a]pyrene-induced mutagenesis in oral tissue and esophagus in lacZ mice.
Topics: Animals; Antimutagenic Agents; Benzo(a)pyrene; DNA; Drug Combinations; Esophagus; Male; Mice; Mutagenesis; Mutagenicity Tests; Organoselenium Compounds; Selenium; Thiones; Thiophenes; Tongue; Yeasts | 2004 |
Induction of phase II enzymes by 3H-1,2-dithiole-3-thione: dose-response study in rats.
Topics: Animals; Dose-Response Relationship, Drug; Enzyme Induction; Female; Glutathione Transferase; Inactivation, Metabolic; NAD(P)H Dehydrogenase (Quinone); Rats; Rats, Sprague-Dawley; Thiones; Thiophenes; Tissue Distribution | 2004 |
In vitro-in vivo antifungal evaluation and structure-activity relationships of 3H-1,2-dithiole-3-thione derivatives.
Topics: Animals; Antifungal Agents; Guinea Pigs; Humans; Microbial Sensitivity Tests; Structure-Activity Relationship; Thiones; Thiophenes; Tinea; Tritium | 2004 |
The chemical inducibility of mouse cardiac antioxidants and phase 2 enzymes in vivo.
Topics: Animals; Antioxidants; Catalase; Enzyme Induction; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Liver; Male; Mice; Mice, Inbred C57BL; Myocardium; Quinone Reductases; Superoxide Dismutase; Thiones; Thiophenes | 2004 |
1,2-dithiole-3-ones as potent inhibitors of the bacterial 3-ketoacyl acyl carrier protein synthase III (FabH).
Topics: Anti-Bacterial Agents; Bacteria; Databases, Factual; Escherichia coli; Ligands; Microbial Sensitivity Tests; Models, Molecular; Protein Synthesis Inhibitors; Spectrometry, Fluorescence; Staphylococcus aureus; Thiones; Thiophenes; Transferases (Other Substituted Phosphate Groups) | 2004 |
Oltipraz, 3H-1,2-dithiole-3-thione, and sulforaphane induce overlapping and protective antioxidant responses in murine microglial cells.
Topics: Animals; Antioxidants; Blotting, Western; Cell Line; Cells, Cultured; DNA, Complementary; Hydrogen Peroxide; Isothiocyanates; Lipopolysaccharides; Mice; Microglia; Microscopy, Fluorescence; Oligonucleotide Array Sequence Analysis; Oxidants; Oxidative Stress; Pyrazines; Reactive Oxygen Species; RNA; Stimulation, Chemical; Sulfoxides; Thiocyanates; Thiones; Thiophenes | 2004 |
Protecting against peroxynitrite-mediated cytotoxicity in vascular smooth muscle cells via upregulating endogenous glutathione biosynthesis by 3H-1,2-dithiole-3-thione.
Topics: Animals; Antineoplastic Agents; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Dipeptides; Dose-Response Relationship, Drug; Drug Antagonism; Drug Combinations; Glutathione; Molsidomine; Muscle, Smooth, Vascular; Peroxynitrous Acid; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiones; Thiophenes; Up-Regulation | 2004 |
Role of Nrf2 signaling in regulation of antioxidants and phase 2 enzymes in cardiac fibroblasts: protection against reactive oxygen and nitrogen species-induced cell injury.
Topics: Animals; Antioxidants; Catalase; Cells, Cultured; DNA-Binding Proteins; Enzyme Induction; Fibroblasts; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Heart; Mice; Mice, Knockout; Myocardium; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Reactive Nitrogen Species; Reactive Oxygen Species; RNA, Messenger; Signal Transduction; Superoxide Dismutase; Thiones; Thiophenes; Trans-Activators; Xanthine | 2005 |
log P estimation of 1,2-dithiole-3-thiones and 1,2-dithiole-3-ones: a comparison of experimental and calculative approaches.
Topics: Calorimetry; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Databases, Factual; Indicators and Reagents; Octanols; Solubility; Spectrophotometry, Ultraviolet; Thiones; Thiophenes; Water | 2005 |
Divergent responses of chondrocytes and endothelial cells to shear stress: cross-talk among COX-2, the phase 2 response, and apoptosis.
Topics: Antineoplastic Agents; Antioxidants; Apoptosis; Chondrocytes; Cyclooxygenase Inhibitors; Endothelial Cells; Humans; Isothiocyanates; Mitogen-Activated Protein Kinase 9; Oligonucleotide Array Sequence Analysis; Phosphatidylinositol 3-Kinases; Response Elements; Shear Strength; Signal Transduction; Stress, Mechanical; Sulfoxides; Thiocyanates; Thiones; Thiophenes; Transcription, Genetic | 2005 |
Identification of novel transcriptional networks in response to treatment with the anticarcinogen 3H-1,2-dithiole-3-thione.
Topics: Animals; Anticarcinogenic Agents; Antigen Presentation; Cholesterol; Cluster Analysis; Cytosol; Gene Expression Regulation; Gene Regulatory Networks; Glutathione; Interferon Regulatory Factor-1; Lipid Metabolism; Liver; Male; Oligonucleotide Array Sequence Analysis; Rats; Rats, Inbred F344; Reproducibility of Results; Ribosomes; Thiones; Thiophenes; Transcription, Genetic; Tryptophan | 2006 |
3H-1,2-dithiole-3-thione targets nuclear factor kappaB to block expression of inducible nitric-oxide synthase, prevents hypotension, and improves survival in endotoxemic rats.
Topics: Animals; Blotting, Western; Electrophoresis, Polyacrylamide Gel; Electrophoretic Mobility Shift Assay; Endotoxemia; Glutathione; Hypotension; Lipopolysaccharides; Liver; Male; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Rats; Rats, Inbred F344; Thiones; Thiophenes | 2006 |
Structure-activity relationships in the induction of Phase II enzymes by derivatives of 3H-1,2-dithiole-3-thione in rats.
Topics: Animals; Antineoplastic Agents; Enzyme Induction; Female; Glutathione Transferase; Metabolic Detoxication, Phase II; NAD(P)H Dehydrogenase (Quinone); Pyrazines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiones; Thiophenes | 2006 |
In vivo modulation of the Parkinsonian phenotype by Nrf2.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antineoplastic Agents; Autoradiography; Cocaine; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Drug Interactions; Iodine Isotopes; Male; Mice; Mice, Inbred ICR; Mice, Knockout; NF-E2-Related Factor 2; Parkinsonian Disorders; Phenotype; Thiones; Thiophenes | 2006 |
Glutathione and glutathione-linked enzymes in normal human aortic smooth muscle cells: chemical inducibility and protection against reactive oxygen and nitrogen species-induced injury.
Topics: Antineoplastic Agents; Aorta; Buthionine Sulfoximine; Cells, Cultured; Cytoprotection; Enzyme Inhibitors; Glutamate-Cysteine Ligase; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Humans; Mitochondria; Muscle, Smooth, Vascular; Reactive Nitrogen Species; Reactive Oxygen Species; RNA, Messenger; Thiones; Thiophenes; Xanthine Oxidase | 2007 |
The thiol antioxidant 1,2-dithiole-3-thione stimulates the expression of heat shock protein 70 in dopaminergic PC12 cells.
Topics: Animals; Antineoplastic Agents; Antioxidants; Dopamine; Gene Expression; HSP70 Heat-Shock Proteins; NAD(P)H Dehydrogenase (Quinone); Neurons; Oxidative Stress; PC12 Cells; Rats; RNA, Messenger; Thiones; Thiophenes | 2007 |
Upregulation of endogenous glutathione system by 3H-1,2-dithiole-3-thione in pancreatic RINm5F beta-cells as a novel strategy for protecting against oxidative beta-cell injury.
Topics: Animals; Antioxidants; Buthionine Sulfoximine; Cell Line; Drug Evaluation, Preclinical; Enzyme Induction; Glutamate-Cysteine Ligase; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Insulin-Secreting Cells; Oxidants; Oxidative Stress; Rats; Reactive Oxygen Species; Thiones; Thiophenes; Up-Regulation | 2007 |
Induction of Nrf2-regulated genes by 3H-1, 2-dithiole-3-thione through the ERK signaling pathway in murine keratinocytes.
Topics: Animals; Antioxidants; Blotting, Western; Cell Nucleus; DNA; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Genes, Reporter; Keratinocytes; Luciferases; Mice; NAD(P)H Dehydrogenase (Quinone); NADPH Dehydrogenase; NF-E2-Related Factor 2; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; RNA; Signal Transduction; Thiones; Thiophenes; Transcriptional Activation; Transfection | 2007 |
Generation of superoxide from reaction of 3H-1,2-dithiole-3-thione with thiols: implications for dithiolethione chemoprotection.
Topics: Antineoplastic Agents; Chemoprevention; Dithiothreitol; Dose-Response Relationship, Drug; Glutathione; Oxidation-Reduction; Oxygen Consumption; Pyrroles; Reactive Oxygen Species; Spin Trapping; Sulfhydryl Compounds; Superoxide Dismutase; Superoxides; Thioinosine; Thiones; Thiophenes | 2008 |
Potent induction of total cellular GSH and NQO1 as well as mitochondrial GSH by 3H-1,2-dithiole-3-thione in SH-SY5Y neuroblastoma cells and primary human neurons: protection against neurocytotoxicity elicited by dopamine, 6-hydroxydopamine, 4-hydroxy-2-no
Topics: Aldehydes; Antioxidants; Cell Line, Tumor; Cells, Cultured; Dopamine; Glutathione; Humans; Hydrogen Peroxide; Mitochondria; NAD(P)H Dehydrogenase (Quinone); Nerve Degeneration; Neurons; Neuroprotective Agents; Oxidative Stress; Oxidopamine; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiones; Thiophenes | 2008 |
Nuclear factor E2-related factor 2-dependent myocardiac cytoprotection against oxidative and electrophilic stress.
Topics: Animals; Animals, Newborn; Antioxidants; Catalase; Cell Survival; Cells, Cultured; Cytoprotection; Dose-Response Relationship, Drug; Electrophoresis; Gene Expression Regulation, Enzymologic; Glutamate-Cysteine Ligase; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Heme Oxygenase (Decyclizing); Metabolic Detoxication, Phase II; Mice; Mice, Inbred ICR; Mice, Knockout; Myocytes, Cardiac; NAD(P)H Dehydrogenase (Quinone); NADPH Dehydrogenase; NF-E2-Related Factor 2; Oxidants; Oxidative Stress; Signal Transduction; Superoxide Dismutase; Thiones; Thiophenes; Time Factors | 2008 |
Renal protection by 3H-1,2-dithiole-3-thione against cisplatin through the Nrf2-antioxidant pathway.
Topics: Animals; Antineoplastic Agents; Antioxidants; Base Sequence; Cisplatin; Cytoprotection; DNA Primers; Epithelial Cells; Gene Expression Regulation; Kidney; Mice; NF-E2-Related Factor 2; Reverse Transcriptase Polymerase Chain Reaction; Thiones; Thiophenes | 2008 |
Nrf2-mediated transcriptional induction of antioxidant response in mouse embryos exposed to ethanol in vivo: implications for the prevention of fetal alcohol spectrum disorders.
Topics: Animals; Apoptosis; Blotting, Western; Caspase 3; Catalase; Embryo, Mammalian; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Gene Expression Regulation, Developmental; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Mice; Mice, Inbred C57BL; NAD(P)H Dehydrogenase (Quinone); NADPH Dehydrogenase; NF-E2-Related Factor 2; Oxidative Stress; Pregnancy; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Superoxide Dismutase; Thiones; Thiophenes; Thioredoxins; Up-Regulation | 2008 |
Induction of sulfiredoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H-1,2-dithiole-3-thione.
Topics: Animals; Antioxidants; Apoptosis; Cerebral Cortex; Drug Interactions; Embryo, Mammalian; Enzyme Activation; Hydrogen Peroxide; Hydroquinones; Indoles; Mice; Mutation; Nerve Tissue Proteins; Neuroglia; Neurons; NF-E2-Related Factor 2; Oxidative Stress; Oxidoreductases; Peroxiredoxins; Rats; RNA, Messenger; Thiones; Thiophenes; Transcription Factor AP-1; Transfection; Up-Regulation | 2008 |
Upregulation of cellular glutathione by 3H-1,2-dithiole-3-thione as a possible treatment strategy for protecting against acrolein-induced neurocytotoxicity.
Topics: Acrolein; Aldehyde Reductase; Buthionine Sulfoximine; Cell Line, Tumor; Cell Survival; Cells, Cultured; Cytoprotection; Enzyme Induction; Glutamate-Cysteine Ligase; Glutathione; Glutathione Transferase; Humans; L-Lactate Dehydrogenase; Neurons; Thiones; Thiophenes; Up-Regulation | 2009 |
Chemical genomics of cancer chemopreventive dithiolethiones.
Topics: Animals; Anticarcinogenic Agents; Cytochrome P-450 CYP1A2; Gene Expression Profiling; Genomics; Glutathione; Heterocyclic Compounds, 1-Ring; Liver; Male; Multigene Family; NF-E2-Related Factor 2; Oligonucleotide Array Sequence Analysis; Pyrazines; Rats; Rats, Inbred F344; Structure-Activity Relationship; Thiones; Thiophenes | 2009 |
Cruciferous dithiolethione-mediated coordinated induction of total cellular and mitochondrial antioxidants and phase 2 enzymes in human primary cardiomyocytes: cytoprotection against oxidative/electrophilic stress and doxorubicin toxicity.
Topics: Aldehydes; Antineoplastic Agents; Antioxidants; Cell Line; Cytoprotection; Doxorubicin; Humans; Metabolic Detoxication, Phase II; Mitochondria; Molsidomine; Myocytes, Cardiac; Oxidative Stress; Reactive Oxygen Species; Thiones; Thiophenes; Up-Regulation; Xanthine Oxidase | 2009 |
Cruciferous nutraceutical 3H-1,2-dithiole-3-thione protects human primary astrocytes against neurocytotoxicity elicited by MPTP, MPP(+), 6-OHDA, HNE and acrolein.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Acrolein; Aldehydes; Astrocytes; Brassicaceae; Cells, Cultured; Glutathione; Glutathione Reductase; Humans; NAD(P)H Dehydrogenase (Quinone); Oxidants; Oxidopamine; RNA, Messenger; Thiones; Thiophenes | 2009 |
Induced expression of drug metabolizing enzymes by preventive agents: role of the antioxidant response element.
Topics: Allyl Compounds; Animals; Anticarcinogenic Agents; Antioxidants; beta-Naphthoflavone; Enzyme Induction; Ethoxyquin; Female; Gene Expression Regulation; Glutathione Transferase; Liver; NAD(P)H Dehydrogenase (Quinone); Oligonucleotide Array Sequence Analysis; Phenobarbital; Rats; Rats, Sprague-Dawley; Response Elements; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfhydryl Compounds; Sulfides; Thiones; Thiophenes | 2009 |
Hydrogen peroxide is a second messenger in phase 2 enzyme induction by cancer chemopreventive dithiolethiones.
Topics: Animals; Antineoplastic Agents; Antioxidants; Cyclic N-Oxides; Diglycerides; Enzyme Induction; Hepatocytes; Humans; Hydrogen Peroxide; NAD(P)H Dehydrogenase (Quinone); Neoplasms; Pyrazines; Second Messenger Systems; Thiones; Thiophenes | 2009 |
HPLC determination of novel dithiolethione containing drugs and its application for in vivo studies in rats.
Topics: Animals; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Rats; Rats, Sprague-Dawley; Spectrophotometry, Ultraviolet; Thiones; Thiophenes | 2010 |
Synthesis, biological evaluation, and structure-activity relationships of dithiolethiones as inducers of cytoprotective phase 2 enzymes.
Topics: Animals; Anticarcinogenic Agents; Cell Line, Tumor; Enzyme Induction; Female; Gene Knockdown Techniques; Glutathione Transferase; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Organ Specificity; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiones; Thiophenes; Urinary Bladder; Urinary Bladder Neoplasms | 2010 |
Inactivation of protein tyrosine phosphatases by oltipraz and other cancer chemopreventive 1,2-dithiole-3-thiones.
Topics: Anticarcinogenic Agents; Catalytic Domain; Humans; Mass Spectrometry; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Pyrazines; Reactive Oxygen Species; Recombinant Proteins; Thiones; Thiophenes | 2010 |
Stabilization of Nrf2 protein by D3T provides protection against ethanol-induced apoptosis in PC12 cells.
Topics: Animals; Antioxidants; Apoptosis; Cytoprotection; Drug Evaluation, Preclinical; Ethanol; Mice; NF-E2-Related Factor 2; PC12 Cells; Protein Stability; Rats; Thiones; Thiophenes | 2011 |
Fyn inhibition by cycloalkane-fused 1,2-dithiole-3-thiones enhances antioxidant capacity and protects mitochondria from oxidative injury.
Topics: AMP-Activated Protein Kinases; Antioxidants; Arachidonic Acid; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Cycloparaffins; Hep G2 Cells; Humans; Hydrogen Peroxide; Iron; Mitochondria; NF-E2-Related Factor 2; Oxidative Stress; Phosphorylation; Proto-Oncogene Proteins c-fyn; Superoxides; Thiones; Thiophenes | 2012 |
Nrf2-mediated resistance to oxidant-induced redox disruption in embryos.
Topics: Animals; Embryo, Mammalian; Female; Gene Expression Regulation, Developmental; Glutathione; Hydrogen Peroxide; Mice; Mice, Inbred ICR; NF-E2-Related Factor 2; Oxidants; Oxidation-Reduction; Thiones; Thiophenes; Thioredoxins | 2012 |
The antioxidant 3H-1,2-dithiole-3-thione potentiates advanced glycation end-product-induced oxidative stress in SH-SY5Y cells.
Topics: Antioxidants; Cell Line, Tumor; Cell Survival; Diabetes Mellitus; Glutathione; Glycation End Products, Advanced; Humans; Hydrogen Peroxide; NAD(P)H Dehydrogenase (Quinone); Oxidative Stress; Reactive Oxygen Species; Thiones; Thiophenes | 2012 |
A serendipitous one-step conversion of 3H-1,2-dithiole-3-thione to (E)-3-[1-(alkylthio)alkylidene]-3H-1,2-dithiole: an experimental and theoretical study.
Topics: Chemoprevention; Models, Molecular; Molecular Conformation; Quantum Theory; Thiones; Thiophenes; Toluene | 2014 |
Extracellular redox state regulates catecholamine biosynthesis in PC12 cells with insulin resistance.
Topics: Animals; Antioxidants; Catecholamines; Cell Survival; Cysteine; Cystine; Extracellular Space; Insulin Resistance; NF-E2-Related Factor 2; Oxidation-Reduction; PC12 Cells; Rats; Reactive Oxygen Species; Thiones; Thiophenes | 2014 |
Induction of complementary function reductase enzymes in colon cancer cells by dithiole-3-thione versus sodium selenite.
Topics: Antineoplastic Agents; Cell Line, Tumor; Colonic Neoplasms; Enzyme Induction; Gene Expression Regulation, Neoplastic; Humans; NAD(P)H Dehydrogenase (Quinone); Neoplasm Proteins; NF-E2-Related Factor 2; Sodium Selenite; Thiones; Thiophenes; Thioredoxin Reductase 1; Trace Elements | 2015 |
Pharmacological induction of ferritin prevents osteoblastic transformation of smooth muscle cells.
Topics: Alkaline Phosphatase; Aorta; Calcitriol; Calcium; Cells, Cultured; Cholecalciferol; Ergocalciferols; Ferritins; Glycerophosphates; Humans; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Osteoblasts; Osteocalcin; Phosphates; Thiones; Thiophenes; Vascular Calcification | 2016 |
3H-1,2-dithiole-3-thione as a novel therapeutic agent for the treatment of experimental autoimmune encephalomyelitis.
Topics: Animals; Anti-Inflammatory Agents; Dendritic Cells; Encephalomyelitis, Autoimmune, Experimental; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Th1 Cells; Th17 Cells; Thiones; Thiophenes | 2016 |
3H-1,2-dithiole-3-thione protects retinal pigment epithelium cells against Ultra-violet radiation via activation of Akt-mTORC1-dependent Nrf2-HO-1 signaling.
Topics: Animals; Apoptosis; Cells, Cultured; Heme Oxygenase-1; Humans; Mechanistic Target of Rapamycin Complex 1; Membrane Proteins; Mice, Inbred C57BL; NF-E2-Related Factor 2; Proto-Oncogene Proteins c-akt; Radiation-Protective Agents; Reactive Oxygen Species; Retinal Pigment Epithelium; Signal Transduction; Thiones; Thiophenes; Ultraviolet Rays | 2016 |
Synthesis and biological evaluation of 1,2-dithiol-3-thiones and pyrrolo[1,2-a]pyrazines as novel hypoxia inducible factor-1 (HIF-1) inhibitor.
Topics: Antineoplastic Agents; Glucose Transporter Type 1; HCT116 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin; Pyrazines; Thiones; Thiophenes; Transcriptional Activation; Vascular Endothelial Growth Factor A | 2016 |
4,5-Diaryl-3H-1,2-dithiole-3-thiones and related compounds as combretastatin A-4/oltipraz hybrids: Synthesis, molecular modelling and evaluation as antiproliferative agents and inhibitors of tubulin.
Topics: Antineoplastic Agents; Bibenzyls; Cell Cycle; Cell Proliferation; Chemistry Techniques, Synthetic; Drug Screening Assays, Antitumor; Humans; KB Cells; Molecular Docking Simulation; Protein Multimerization; Protein Structure, Quaternary; Pyrazines; Structure-Activity Relationship; Thiones; Thiophenes; Tubulin; Tubulin Modulators | 2016 |
Protective effect of 3H-1, 2-dithiole-3-thione on cellular model of Alzheimer's disease involves Nrf2/ARE signaling pathway.
Topics: Active Transport, Cell Nucleus; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Cell Line, Tumor; Cell Nucleus; Cell Survival; Cytoprotection; Down-Regulation; Gene Expression Regulation; Glutathione; Heme Oxygenase-1; Intracellular Space; Kelch-Like ECH-Associated Protein 1; Malondialdehyde; Mice; Mitochondria; Molecular Targeted Therapy; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Oxidative Stress; Peptide Fragments; Reactive Oxygen Species; Response Elements; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Thiones; Thiophenes | 2017 |
3H-1,2-Dithiole-3-thione as a novel therapeutic agent for the treatment of ischemic stroke through Nrf2 defense pathway.
Topics: Animals; Antioxidants; Brain Ischemia; Disease Models, Animal; Infarction, Middle Cerebral Artery; Mice; NF-E2-Related Factor 2; Reactive Oxygen Species; Signal Transduction; Stroke; Thiones; Thiophenes | 2017 |
Pharmacological activation of the Nrf2 pathway by 3H-1, 2-dithiole-3-thione is neuroprotective in a mouse model of Alzheimer disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Disease Models, Animal; Heme Oxygenase-1; Hippocampus; Male; Mice; Mice, Inbred C57BL; Neurogenesis; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Thiones; Thiophenes | 2018 |
Dithiolethione ACDT suppresses neuroinflammation and ameliorates disease severity in experimental autoimmune encephalomyelitis.
Topics: Animals; Central Nervous System; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Macrophage Activation; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin Sheath; Th1 Cells; Th17 Cells; Thiones; Thiophenes | 2018 |
Augmented NRF2 activation protects adult sickle mice from lethal acute chest syndrome.
Topics: Acute Chest Syndrome; Animals; Hematinics; Heme Oxygenase-1; Hemin; Mice, Transgenic; NF-E2-Related Factor 2; Oxygen; Thiones; Thiophenes | 2018 |
5-(4-Hydroxyphenyl)-3H-1,2-dithiole-3-thione-based fibrates as potential hypolipidemic and hepatoprotective agents.
Topics: Animals; Diet, High-Fat; Fibric Acids; Hyperlipidemias; Hypolipidemic Agents; Lipid Metabolism; Liver; Male; Mice; Protective Agents; Thiones; Thiophenes | 2018 |
D3T acts as a pro-oxidant in a cell culture model of diabetes-induced peripheral neuropathy.
Topics: Antioxidants; Cell Line, Tumor; Cell Survival; Dehydroepiandrosterone; Diabetic Neuropathies; Glutathione; Glutathione Transferase; Glycation End Products, Advanced; Humans; Models, Biological; Neurites; Oxidative Stress; Thiones; Thiophenes | 2019 |
Potential Role of H-Ferritin in Mitigating Valvular Mineralization.
Topics: Aortic Valve; Aortic Valve Stenosis; Apoferritins; Biological Transport; Cell Nucleus; Cells, Cultured; Core Binding Factor Alpha 1 Subunit; Endothelial Cells; Gene Expression Regulation; Interleukin-1beta; Ion Channels; Iron; Lysosomes; Phosphates; Phosphoric Diester Hydrolases; SOX9 Transcription Factor; Thiones; Thiophenes; Tumor Necrosis Factor-alpha; Vascular Calcification | 2019 |
Use of Primary Mouse Embryonic Fibroblasts in Developmental Toxicity Assessments.
Topics: Animals; Cell Culture Techniques; Cell Differentiation; Cell Proliferation; Cell Survival; Cells, Cultured; Embryo, Mammalian; Female; Fibroblasts; Gene Knockout Techniques; Hydrogen Peroxide; Mercury; Mice; Mice, Transgenic; Models, Biological; NF-E2-Related Factor 2; Thiones; Thiophenes; Toxicity Tests | 2019 |
Controlled release of hydrogen sulfide significantly reduces ROS stress and increases dopamine levels in transgenic C. elegans.
Topics: alpha-Synuclein; Animals; Animals, Genetically Modified; Anti-Inflammatory Agents; Antioxidants; Caenorhabditis elegans; Dopamine; Drug Liberation; Hydrogen Sulfide; Oxidation-Reduction; Oxidative Stress; Peptides; Phosphines; Prodrugs; Reactive Oxygen Species; Thiones; Thiophenes | 2019 |
Spatiotemporal evaluation of the mouse embryonic redox environment and histiotrophic nutrition following treatment with valproic acid and 1,2-dithiole-3-thione during early organogenesis.
Topics: Amino Acids; Animals; Anticonvulsants; Antineoplastic Agents; Cysteine; Embryo, Mammalian; Female; Glutamate-Cysteine Ligase; Glutathione; Heme Oxygenase-1; Maternal-Fetal Exchange; Membrane Proteins; Mice; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Organogenesis; Oxidation-Reduction; Pregnancy; Thiones; Thiophenes; Valproic Acid | 2021 |
3H-1,2-dithiole-3-thione suppresses LPS-induced proinflammatory responses in macrophages: potential involvement of antioxidant induction, NF-κB, and Nrf2.
Topics: Animals; Antioxidants; Glutathione; Lipopolysaccharides; Macrophages; Mice; NF-E2-Related Factor 2; NF-kappa B; Thiones; Thiophenes | 2022 |