thiophenes has been researched along with 1-(5-((2,4-difluorophenyl)thio)-4-nitrothiophen-2-yl)ethanone in 15 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (46.67) | 24.3611 |
| 2020's | 8 (53.33) | 2.80 |
| Authors | Studies |
|---|---|
| Altun, M; Dianov, GL; Fischer, R; Goldenberg, SJ; Kessler, BM; Khoronenkova, SV; Kogan, E; Konietzny, R; Kramer, HB; Kumar, KG; Leach, CA; Mackeen, MM; McDermott, JL; McGouran, J; Nicholson, B; Parsons, JL; Willems, LI | 1 |
| Dar, A; Dutta, A; Shibata, E | 1 |
| Cheng, J; Dou, J; Fan, YH; Kim, ES; Ma, IT; Nuchtern, JG; Patel, RH; Rojas, Y; Shohet, JM; Vasudevan, SA; Yang, J; Yu, Y; Zhang, H; Zhao, Y | 1 |
| Fraedrich, K; Friedrich, M; Matthaei, A; Rauch, P; Schubert, U; Setz, C; Traxdorf, M | 1 |
| Adamia, S; Anderson, KC; Bhatt, S; Buhrlage, SJ; Chauhan, D; Christie, A; Christodoulou, A; De Cesare, V; Dhe-Paganon, S; Doherty, L; Gokhale, PC; Gray, NS; Griffin, JD; Lamberto, I; Letai, A; Meng, C; Nonami, A; Ritorto, MS; Sattler, M; Schauer, NJ; Seo, HS; Stone, R; Tiv, H; Trost, M; Weinstock, DM; Weisberg, EL; Wright, R; Yang, J | 1 |
| Bezsonova, I; Kanyo, J; Kumar, KGS; Nguyen, P; Pozhidaeva, A; Sterner, DE; Valles, G; Wang, F; Weinstock, J; Wright, D; Wu, J | 1 |
| Anderson, KC; Buhrlage, SJ; Chauhan, D; Das, D; Dhe-Paganon, S; Engen, JR; Hu, W; Iacob, RE; Lamberto, I; Liu, X; Mikhailova, T; Schauer, NJ; Seo, HS; Weisberg, EL | 1 |
| Chen, X; Fu, Q; Liu, J; Lv, H; Miao, Y; Qian, F; Qian, G; Qian, L; Wang, J; Wang, X; Yu, Z; Yuan, Y; Zeng, C; Zheng, H | 1 |
| Budamagunta, V; Campisi, J; He, Y; Li, W; Lv, D; Ortiz, YT; Zhang, X; Zheng, G; Zhou, D | 1 |
| Deng, J; Liang, L; Liu, J; Nie, L; Su, T; Yang, Z; Yi, H | 1 |
| Chen, H; Fan, Y; Ma, P; Mao, R; Sun, R; Wang, Z; Zhang, E; Zhou, G; Zhu, X | 1 |
| Chen, WL; Di, QQ; Ji, FY; Li, HR; Ling, J; Ma, XY; Zhao, XB; Zhao, ZZ; Zhu, HH | 1 |
| Jang, HR; Kim, CH; Shin, SB; Yim, H | 1 |
| Chen, GQ; Fang, ZX; Gao, FH; Gao, SM; Jin, J; Jing, B; Lei, H; Liu, CX; Liu, LG; Liu, M; Lu, Y; Shan, HZ; Tong, Y; Wang, WW; Wu, YL; Wu, YZ; Xia, L; Xiao, XH; Xu, HZ; Yang, L; Zheng, JK; Zhou, L | 1 |
| Chen, X; Kuang, X; Liang, L; Liu, H; Liu, J; Su, J; Xiang, M; Xie, Z; Zhao, S | 1 |
15 other study(ies) available for thiophenes and 1-(5-((2,4-difluorophenyl)thio)-4-nitrothiophen-2-yl)ethanone
| Article | Year |
|---|---|
Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes.
Topics: Aminopyridines; Antibodies; Cell Line; Chromatography, High Pressure Liquid; Enzyme Activation; Enzyme Inhibitors; Humans; Proteomics; RNA Interference; Tandem Mass Spectrometry; Thiocyanates; Thiophenes; Ubiquitin Thiolesterase; Ubiquitin-Specific Peptidase 7 | 2011 |
Deubiquitination of Tip60 by USP7 determines the activity of the p53-dependent apoptotic pathway.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Cell Line; Cell Line, Tumor; Histone Acetyltransferases; Humans; Lysine Acetyltransferase 5; Proteolysis; Proto-Oncogene Proteins; Thiophenes; Tumor Suppressor Protein p53; Ubiquitin Thiolesterase; Ubiquitin-Specific Peptidase 7; Ubiquitination | 2013 |
USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Herpes Simplex Virus Protein Vmw65; Humans; Mice; Neuroblastoma; Protease Inhibitors; Proto-Oncogene Proteins c-mdm2; Signal Transduction; Thiophenes; Treatment Outcome; Tumor Suppressor Protein p53; Ubiquitin Thiolesterase; Ubiquitin-Specific Peptidase 7; Xenograft Model Antitumor Assays | 2013 |
Inhibitors of Deubiquitinating Enzymes Block HIV-1 Replication and Augment the Presentation of Gag-Derived MHC-I Epitopes.
Topics: Aminopyridines; Anti-HIV Agents; Deubiquitinating Enzymes; gag Gene Products, Human Immunodeficiency Virus; Genes, MHC Class I; HIV Infections; HIV-1; Humans; Thiocyanates; Thiophenes; Ubiquitination; Virus Replication | 2017 |
Inhibition of USP10 induces degradation of oncogenic FLT3.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Mice; Mice, Inbred NOD; Molecular Structure; Mutation; Neoplasms, Experimental; Protein Kinase Inhibitors; Small Molecule Libraries; Structure-Activity Relationship; Thiophenes; Tumor Cells, Cultured; Ubiquitin; Ubiquitin Thiolesterase | 2017 |
USP7-Specific Inhibitors Target and Modify the Enzyme's Active Site via Distinct Chemical Mechanisms.
Topics: Catalytic Domain; Humans; Models, Molecular; Molecular Structure; Protease Inhibitors; Structure-Activity Relationship; Substrate Specificity; Thiophenes; Ubiquitin; Ubiquitin-Specific Peptidase 7 | 2017 |
Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7.
Topics: Catalytic Domain; Dose-Response Relationship, Drug; Drug Design; Humans; Models, Molecular; Molecular Structure; Protease Inhibitors; Structure-Activity Relationship; Substrate Specificity; Thiophenes; Ubiquitin; Ubiquitin-Specific Peptidase 7 | 2017 |
Small-molecule inhibitors of ubiquitin-specific protease 7 enhance type-I interferon antiviral efficacy by destabilizing SOCS1.
Topics: A549 Cells; Antiviral Agents; Enzyme Inhibitors; HEK293 Cells; HeLa Cells; Host-Pathogen Interactions; Humans; Influenza A Virus, H1N1 Subtype; Interferon-alpha; Janus Kinases; Protein Binding; Protein Stability; Proteolysis; Signal Transduction; Suppressor of Cytokine Signaling 1 Protein; Thiophenes; Time Factors; Ubiquitin-Specific Peptidase 7; Ubiquitination; Vesiculovirus | 2020 |
Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity.
Topics: Animals; Apoptosis; Cell Survival; Cellular Senescence; Doxorubicin; HEK293 Cells; Human Umbilical Vein Endothelial Cells; Humans; Mice; Proto-Oncogene Proteins c-mdm2; RNA Interference; Signal Transduction; Thiophenes; Transfection; Tumor Suppressor Protein p53; Ubiquitin-Specific Peptidase 7; Ubiquitination | 2020 |
USP7 inhibition inhibits proliferation and induces megakaryocytic differentiation in MDS cells by upregulating gelsolin.
Topics: Animals; Apoptosis; Cell Cycle Checkpoints; Cell Line; Enzyme Induction; Gelsolin; Heterografts; Humans; Megakaryocytes; Mice; Mice, Inbred NOD; Myelodysplastic Syndromes; Neoplasms, Experimental; Protease Inhibitors; Risk; Thiophenes; Thrombopoiesis; Transcriptome; Ubiquitin-Specific Peptidase 7; Up-Regulation | 2020 |
Ubiquitin-specific protease 7 is a druggable target that is essential for pancreatic cancer growth and chemoresistance.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Mice, Nude; Pancreatic Neoplasms; Thiophenes; Ubiquitin-Specific Peptidase 7 | 2020 |
P22077 inhibits LPS-induced inflammatory response by promoting K48-linked ubiquitination and degradation of TRAF6.
Topics: Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; Cytokines; Female; Inflammation; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred C57BL; NF-kappa B; Nitric Oxide Synthase Type II; RAW 264.7 Cells; Signal Transduction; Thiophenes; TNF Receptor-Associated Factor 6; Ubiquitin-Specific Peptidase 7; Ubiquitination | 2020 |
Combination of Inhibitors of USP7 and PLK1 has a Strong Synergism against Paclitaxel Resistance.
Topics: A549 Cells; Cell Cycle Proteins; Drug Resistance, Neoplasm; Humans; Neoplasms; Paclitaxel; Polo-Like Kinase 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Pteridines; Thiophenes; Ubiquitin-Specific Peptidase 7 | 2020 |
Targeting USP47 overcomes tyrosine kinase inhibitor resistance and eradicates leukemia stem/progenitor cells in chronic myelogenous leukemia.
Topics: Animals; Cell Proliferation; DNA Damage; DNA Repair; Drug Resistance, Neoplasm; Extracellular Signal-Regulated MAP Kinases; Fusion Proteins, bcr-abl; Gene Expression Regulation, Leukemic; Humans; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice, Knockout; Neoplastic Stem Cells; Proteasome Endopeptidase Complex; Protein Binding; Protein Kinase Inhibitors; Protein Stability; Proteolysis; ras Proteins; RNA, Messenger; Signal Transduction; STAT5 Transcription Factor; Thiophenes; Ubiquitin Thiolesterase; Ubiquitin-Specific Proteases; Xenograft Model Antitumor Assays; Y-Box-Binding Protein 1 | 2021 |
Pharmacological inhibition of USP7 suppresses growth and metastasis of melanoma cells in vitro and in vivo.
Topics: Animals; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Disease Models, Animal; DNA Damage; Humans; Immunohistochemistry; Melanoma; Melanoma, Experimental; Mice; Reactive Oxygen Species; Thiophenes; Ubiquitin-Specific Peptidase 7 | 2021 |