Compounds > thiophene-2-carboxylate
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thiophene-2-carboxylate and thiophenes

thiophene-2-carboxylate has been researched along with thiophenes in 32 studies

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19906 (18.75)18.7374
1990's5 (15.63)18.2507
2000's10 (31.25)29.6817
2010's11 (34.38)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Arrigoni Martelli, E; Bruno, G; Chassard, D; Douin, MJ; Giubilei, C; Marzo, A; Mignot, A; Nava, D; Thebault, JJ1
Evans, JS; Venables, WA1
Medici, TC; Streit, E1
Alander, C; Onkelinx, C; Raisz, LG; Rodan, GA1
Johannesson, AJ; Onkelinx, C; Raisz, LG; Rodan, GA1
Asaeda, N; Haruyama, K; Ikawa, E; Koide, M; Shinoda, M; Tagawa, Y; Tamano, S1
Badimón, JJ; Borruel, MT; Escolar, G; Martínez, JC; Villaverde, CA1
Funakoshi, Y; Inamori, Y; Muro, C; Numata, A; Tsujibo, H; Usami, Y1
Bambauer, A; Rainey, FA; Stackebrandt, E; Winter, J1
Liebeskind, LS; Savarin, C; Srogl, J1
Liebeskind, LS; Savarin, C1
Li, J; Sun, J; Yuan, L; Zhang, K1
ROBEV, S; TODOROV, S1
BAI, DL; KYI, ZY1
Bédard, J; Bethell, R; Bilimoria, D; Brunette, S; Chan, L; Courchesne, M; Courtemanche-Asselin, P; Das, SK; David, M; Hamel, M; L'Heureux, L; Labrecque, D; Nguyen-Ba, N; Nicolas, O; Pereira, O; Poisson, C; Proulx, M; Reddy, TJ; Roy, C; Siddiqui, A; Wang, W; Yannopoulos, CG1
Bédard, J; Bethell, R; Bilimoria, D; Brunette, S; Chan, L; Courchesne, M; Courtemanche-Asselin, P; Das, SK; David, M; Hamel, M; L'Heureux, L; Moinet, C; Nasturica, D; Nguyen-Ba, N; Nicolas, O; Pereira, O; Poisson, C; Proulx, M; Reddy, TJ; Roy, C; Siddiqui, A; Yannopoulos, CG1
Ali, S; Browner, MF; Cammack, N; Giannetti, AM; Harris, SF; Hendricks, T; Jiang, WR; Kang, H; Klumpp, K; Le Pogam, S; Leveque, V; Nájera, I; Oshiro, C; Rajyaguru, S; Symons, J; Tavares, G1
Dendrinou-Samara, C; Girousi, S; Hadjipavlou-Litina, D; Panagoulis, D; Pontiki, E; Raptopoulou, C; Skeva, E1
Bao, JR; Zhao, YL; Zhu, XW1
Alexakis, A; Falciola, CA1
Herrera-León, L; Jiménez Pajares, MS; Molina Moreno, T; Pozuelo-Díaz, R; Saiz Vega, P; Valverde Cobacho, A1
Austin, R; Kumar, VS; Profeta, S; Young, SS1
Falck, JR; He, A; Li, H; Liebeskind, LS1
Bera, MK; Hommes, P; Reissig, HU1
Dannhardt, G; Geffken, D; Hansen, FK; Khankischpur, M; Mesaros, R; Tolaymat, I1
Bolm, C; Hirano, K; Iitsuka, T; Miura, M; Satoh, T; Schaal, P1
Miyake, Y; Nakajima, K; Nishibayashi, Y; Ota, S; Shibata, M1
Balachandran, V; Karthick, T; Perumal, S1
Karthikeyan, A; Perdih, F; Thomas Muthiah, P1
Fukui, K; Hin, N; Kato, Y; Kurosawa, S; Maita, N; Rojas, C; Slusher, BS; Thomas, AG; Tsukamoto, T; Yorita, K1
Chreifi, G; Evenson, RJ; Li, H; Poulos, TL; Silverman, RB1
Boulsourani, Z; Dendrinou-Samara, C; Geromichalos, GD; Hadjipavlou-Litina, D; Katsamakas, S; Psycharis, V; Raptopoulou, CP; Sahpazidou, D1

Trials

2 trial(s) available for thiophene-2-carboxylate and thiophenes

ArticleYear
Pharmacokinetics of 2-(alpha-thenoylthio)-propionylglycine (TTPG) in healthy volunteers--an oral dose-proportionality investigation.
    Journal of pharmaceutical and biomedical analysis, 1992, Volume: 10, Issue:9

    Topics: Adult; Carboxylic Acids; Chromatography, High Pressure Liquid; Expectorants; Female; Glycine; Half-Life; Humans; Male; Spectrophotometry, Ultraviolet; Sulfides; Thiophenes; Tiopronin

1992
Sodium thiophene carboxylate does not facilitate expectoration.
    The European respiratory journal, 1991, Volume: 4, Issue:6

    Topics: Asthma; Bronchitis; Carboxylic Acids; Double-Blind Method; Drug Evaluation; Expectorants; Female; Humans; Male; Middle Aged; Respiratory Function Tests; Sputum; Thiophenes

1991

Other Studies

30 other study(ies) available for thiophene-2-carboxylate and thiophenes

ArticleYear
Degradation of thiophene-2-carboxylate, furan-2-carboxylate, pyrrole-2-carboxylate and other thiophene derivatives by the bacterium Vibrio YC1.
    Applied microbiology and biotechnology, 1990, Volume: 32, Issue:6

    Topics: Bacteriological Techniques; Biodegradation, Environmental; Carboxylic Acids; Furans; Kinetics; Proline; Soil Microbiology; Thiophenes; Vibrio

1990
Effects of thionaphthene 2-carboxylic acid and related compounds on bone resorption in organ culture.
    Calcified tissue international, 1985, Volume: 37, Issue:5

    Topics: Animals; Bone Resorption; Calcitonin; Calcium; Carboxylic Acids; Cell Division; Cholecalciferol; Organ Culture Techniques; Osteoblasts; Parathyroid Hormone; Prostaglandins E; Rats; Thiophenes

1985
Thionapthene-2-carboxylic acid: a new antihypercalcemic agent.
    Endocrinology, 1985, Volume: 117, Issue:4

    Topics: Administration, Oral; Animals; Bone Resorption; Calcitonin; Carboxylic Acids; Carcinoma 256, Walker; Hypercalcemia; Male; Rats; Thiophenes

1985
[Effect of azosemide (SK-110) and its metabolites on mouse liver].
    The Journal of toxicological sciences, 1984, Volume: 9 Suppl 1

    Topics: Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Carboxylic Acids; Diuretics; Dose-Response Relationship, Drug; Female; Furosemide; Injections, Intraperitoneal; Liver; Male; Mice; Sulfanilamides; Thiophenes

1984
[Synergistic action of sodium thiophencarboxylate and bromhexine in chronic bronchitis in rats].
    Archivos de farmacologia y toxicologia, 1981, Volume: 7, Issue:1

    Topics: Animals; Bromhexine; Bronchitis; Carboxylic Acids; Chronic Disease; Drug Synergism; Drug Therapy, Combination; Expectorants; Rats; Rats, Inbred Strains; Thiophenes

1981
Phytogrowth-inhibitory activities of 2-thiophenecarboxylic acid and its related compounds.
    Biological & pharmaceutical bulletin, 1994, Volume: 17, Issue:1

    Topics: Carboxylic Acids; Plant Development; Plant Growth Regulators; Plants; Seeds; Structure-Activity Relationship; Thiophenes

1994
Characterization of Aquamicrobium defluvii gen. nov. sp. nov., a thiophene-2-carboxylate-metabolizing bacterium from activated sludge.
    Archives of microbiology, 1998, Volume: 169, Issue:4

    Topics: Carboxylic Acids; Cell Division; Coenzyme A Ligases; DNA, Ribosomal; Gram-Negative Bacteria; Microbiological Techniques; Molybdenum; Palmitoyl-CoA Hydrolase; Phylogeny; RNA, Ribosomal, 16S; Sewage; Soil Microbiology; Thiophenes; Tungsten Compounds

1998
Substituted alkyne synthesis under nonbasic conditions: copper carboxylate-mediated, palladium-catalyzed thioalkyne-boronic acid cross-coupling.
    Organic letters, 2001, Jan-11, Volume: 3, Issue:1

    Topics: Alkynes; Boronic Acids; Carboxylic Acids; Catalysis; Copper; Molecular Structure; Palladium; Salicylates; Structure-Activity Relationship; Sulfur Compounds; Thiophenes

2001
Nonbasic, room temperature, palladium-catalyzed coupling of aryl and alkenyl iodides with boronic acids mediated by copper(I) thiophene-2-carboxylate (CuTC).
    Organic letters, 2001, Jul-12, Volume: 3, Issue:14

    Topics: Alkenes; Boronic Acids; Carboxylic Acids; Catalysis; Copper; Hydrocarbons, Iodinated; Molecular Structure; Palladium; Structure-Activity Relationship; Thiophenes

2001
[Luminescence of zinc and europium composite alpha-thiophene carboxylate].
    Guang pu xue yu guang pu fen xi = Guang pu, 2000, Volume: 20, Issue:6

    Topics: Carboxylic Acids; Chelating Agents; Europium; Luminescence; Organometallic Compounds; Spectrophotometry; Spectrophotometry, Infrared; Thiophenes; Zinc

2000
[A study of the effect of N-phenyl-benzamidine, N-phenyl-2-furamidine and N-phenylamide of thiophene-2-carboxylic acid on the radioresistance of suspensions of B. anthracis, B. cereus, Candida albicans and Staphyl. aureus following their irradiation with
    Suvremenna meditsina, 1960, Volume: 11(6)

    Topics: Amides; Amidines; Bacteria; Benzamidines; Candida; Candida albicans; Carboxylic Acids; Gamma Rays; Staphylococcus; Suspensions; Thiophenes

1960
[CHEMOTHERAPEUTIC STUDIES ON SCHISTOSOMIASIS. X. SOME AMIDES DERIVED FROM THIOPHENE-2-CARBOXYLIC, THIOPHENE-2-SULPHONIC ACID AND TETRAHYDROTHIOPHENE-2,5- DICARBOXYLIC ACID].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1962, Volume: 9

    Topics: Amides; Antiprotozoal Agents; Carboxylic Acids; Chemistry, Pharmaceutical; Dicarboxylic Acids; Pharmacology; Research; Schistosomiasis; Sulfonic Acids; Thiophenes

1962
Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 1: Sulfonamides.
    Bioorganic & medicinal chemistry letters, 2004, Feb-09, Volume: 14, Issue:3

    Topics: Carboxylic Acids; Carcinoma, Hepatocellular; Enzyme Inhibitors; Genome, Viral; Hepacivirus; Humans; Liver Neoplasms; Replicon; RNA-Dependent RNA Polymerase; RNA, Viral; Structure-Activity Relationship; Sulfonamides; Thiophenes; Viral Nonstructural Proteins; Virus Replication

2004
Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 2: tertiary amides.
    Bioorganic & medicinal chemistry letters, 2004, Feb-09, Volume: 14, Issue:3

    Topics: Amides; Carboxylic Acids; Carcinoma, Hepatocellular; Enzyme Inhibitors; Genome, Viral; Hepacivirus; Humans; Liver Neoplasms; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Structure; Replicon; RNA-Dependent RNA Polymerase; RNA, Viral; Structure-Activity Relationship; Thiophenes; Viral Nonstructural Proteins; Virus Replication

2004
Selection and characterization of replicon variants dually resistant to thumb- and palm-binding nonnucleoside polymerase inhibitors of the hepatitis C virus.
    Journal of virology, 2006, Volume: 80, Issue:12

    Topics: Antiviral Agents; Carboxylic Acids; Drug Resistance, Viral; Drug Therapy, Combination; Genetic Variation; Hepacivirus; Mutation, Missense; Replicon; RNA-Dependent RNA Polymerase; Selection, Genetic; Thiophenes; Viral Nonstructural Proteins; Virus Replication

2006
Synthesis and pharmacochemical study of new Cu(II) complexes with thiophen-2-yl saturated and alpha,beta-unsaturated substituted carboxylic acids.
    Journal of inorganic biochemistry, 2007, Volume: 101, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biosensing Techniques; Carboxylic Acids; Carrageenan; Copper; Crystallography, X-Ray; DNA; Edema; Female; Free Radicals; Glycine max; Lipid Peroxidation; Lipoxygenase; Lipoxygenase Inhibitors; Male; Molecular Structure; Oxidation-Reduction; Rats; Rats, Inbred F344; Superoxides; Thiophenes

2007
[Synthesis, characterization and fluorescence of Eu3+, Tb3+ complexes with 2-thiophencarboxylic acid and 2,2'-bipyridine].
    Guang pu xue yu guang pu fen xi = Guang pu, 2007, Volume: 27, Issue:3

    Topics: 2,2'-Dipyridyl; Carboxylic Acids; Cations; Europium; Magnetic Resonance Spectroscopy; Spectrometry, Fluorescence; Spectrophotometry, Infrared; Terbium; Thiophenes

2007
High diversity on simple substrates: 1,4-dihalo-2-butenes and other difunctionalized allylic halides for copper-catalyzed S(N)2' reactions.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2008, Volume: 14, Issue:34

    Topics: Alkenes; Alkylation; Carboxylic Acids; Catalysis; Copper; Hydrocarbons, Halogenated; Molecular Structure; Organometallic Compounds; Stereoisomerism; Thiophenes

2008
[Differentiation of species within the Mycobacterium tuberculosis complex by molecular techniques].
    Enfermedades infecciosas y microbiologia clinica, 2009, Volume: 27, Issue:9

    Topics: Animals; Bacterial Proteins; Carboxylic Acids; Cattle; Chaperonin 60; DNA Gyrase; DNA, Bacterial; Humans; Mycobacterium; Mycobacterium bovis; Mycobacterium tuberculosis; Niacin; Nitrates; Phenotype; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Pyrazinamide; Reference Standards; Sensitivity and Specificity; Species Specificity; Thiophenes; Tuberculosis; Tuberculosis, Bovine

2009
Differential reactivity of thiophene-2-carboxylic and thiophene-3-carboxylic acids: Results from DFT and Hartree-Fock theory.
    Journal of molecular graphics & modelling, 2010, Feb-26, Volume: 28, Issue:6

    Topics: Carboxylic Acids; Models, Chemical; Models, Molecular; Static Electricity; Surface Properties; Thermodynamics; Thiophenes

2010
Stereocontrolled synthesis of α-amino-α'-alkoxy ketones by a copper-catalyzed cross-coupling of peptidic thiol esters and α-alkoxyalkylstannanes.
    Organic letters, 2011, Jul-15, Volume: 13, Issue:14

    Topics: Amino Acids; Carboxylic Acids; Catalysis; Copper; Esters; Hydrogen-Ion Concentration; Ketones; Molecular Structure; Organotin Compounds; Peptides; Stereoisomerism; Sulfhydryl Compounds; Thiophenes

2011
In search of oligo(2-thienyl)-substituted pyridine derivatives: a modular approach to di-, tri- and tetra(2-thienyl)pyridines.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2011, Oct-10, Volume: 17, Issue:42

    Topics: Carboxylic Acids; Catalysis; Cyclization; Molecular Structure; Palladium; Pyridines; Spectrometry, Fluorescence; Thiophenes

2011
Efficient synthesis and 5-LOX/COX-inhibitory activity of some 3-hydroxybenzo[b]thiophene-2-carboxylic acid derivatives.
    Bioorganic & medicinal chemistry letters, 2012, Aug-01, Volume: 22, Issue:15

    Topics: Arachidonate 5-Lipoxygenase; Carboxylic Acids; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Lipoxygenase Inhibitors; Protein Binding; Structure-Activity Relationship; Thiophenes

2012
Rhodium-catalyzed C3-selective alkenylation of substituted thiophene-2-carboxylic acids and related compounds.
    The Journal of organic chemistry, 2013, Jul-19, Volume: 78, Issue:14

    Topics: Alkenes; Carboxylic Acids; Catalysis; Molecular Structure; Organometallic Compounds; Rhodium; Thiophenes

2013
Copper-catalyzed nucleophilic trifluoromethylation of propargylic halides.
    Chemical communications (Cambridge, England), 2013, Sep-14, Volume: 49, Issue:71

    Topics: Carboxylic Acids; Catalysis; Copper; Halogens; Silanes; Thiophenes

2013
Spectroscopic investigations, molecular interactions, and molecular docking studies on the potential inhibitor "thiophene-2-carboxylicacid".
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2015, Apr-15, Volume: 141

    Topics: Carboxylic Acids; Dimerization; Hydrogen Bonding; Lewis Acids; Lewis Bases; Molecular Docking Simulation; Quantum Theory; Solvents; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Thermodynamics; Thiophenes; Vibration

2015
Supramolecular architectures in Co(II) and Cu(II) complexes with thiophene-2-carboxylate and 2-amino-4,6-dimethoxypyrimidine ligands.
    Acta crystallographica. Section C, Structural chemistry, 2016, 05-01, Volume: 72, Issue:Pt 5

    Topics: Carboxylic Acids; Cobalt; Coordination Complexes; Copper; Crystallography, X-Ray; Hydrogen Bonding; Ligands; Models, Molecular; Pyrimidines; Thiophenes

2016
Structural basis for potent inhibition of d-amino acid oxidase by thiophene carboxylic acids.
    European journal of medicinal chemistry, 2018, Nov-05, Volume: 159

    Topics: Carboxylic Acids; Crystallography, X-Ray; D-Amino-Acid Oxidase; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Thiophenes

2018
Structural Basis for Isoform Selective Nitric Oxide Synthase Inhibition by Thiophene-2-carboximidamides.
    Biochemistry, 2018, 11-06, Volume: 57, Issue:44

    Topics: Amides; Animals; Carboxylic Acids; Enzyme Inhibitors; Humans; Nitric Oxide Synthase Type I; Protein Conformation; Protein Isoforms; Rats; Thiophenes; X-Ray Diffraction

2018
Mononuclear copper(II) complexes with 2-thiophene carboxylate and N-N donors; DNA interaction, antioxidant/anti-inflammatory and antitumor activity.
    Materials science & engineering. C, Materials for biological applications, 2019, Jan-01, Volume: 94

    Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Antioxidants; Carboxylic Acids; Cattle; Cell Death; Cell Line, Tumor; Copper; DNA; Humans; Kinetics; Molecular Docking Simulation; Spectrometry, Fluorescence; Thiophenes; Viscosity

2019