thiopental and valerenic-acid

thiopental has been researched along with valerenic-acid* in 1 studies

Other Studies

1 other study(ies) available for thiopental and valerenic-acid

Article	Year
Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis. Pharmacology, biochemistry, and behavior, 2004, Volume: 77, Issue:2 We have recently reported the presence of the anxiolytic flavone 6-methylapigenin (MA) and of the sedative and sleep-enhancing flavanone glycoside 2S (-) hesperidin (HN) in Valeriana officinalis and Valeriana wallichii. MA, in turn, was able to potentiate the sleep-inducing properties of HN. The present paper reports the identification in V. officinalis of the flavone glycoside linarin (LN) and the discovery that it has, like HN, sedative and sleep-enhancing properties that are potentiated by simultaneous administration of valerenic acid (VA). These effects should be taken into account when considering the pharmacological actions of valeriana extracts. Topics: Animals; Binding, Competitive; Cerebral Cortex; Drug Synergism; Flunitrazepam; GABA Modulators; Glycosides; Hypnotics and Sedatives; Indenes; Magnetic Resonance Spectroscopy; Male; Plant Extracts; Rats; Rats, Wistar; Sesquiterpenes; Sleep; Spectrophotometry, Ultraviolet; Synaptosomes; Thiopental; Valerian	2004

Article

Year

Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis.

Pharmacology, biochemistry, and behavior, 2004, Volume: 77, Issue:2

We have recently reported the presence of the anxiolytic flavone 6-methylapigenin (MA) and of the sedative and sleep-enhancing flavanone glycoside 2S (-) hesperidin (HN) in Valeriana officinalis and Valeriana wallichii. MA, in turn, was able to potentiate the sleep-inducing properties of HN. The present paper reports the identification in V. officinalis of the flavone glycoside linarin (LN) and the discovery that it has, like HN, sedative and sleep-enhancing properties that are potentiated by simultaneous administration of valerenic acid (VA). These effects should be taken into account when considering the pharmacological actions of valeriana extracts.

Topics: Animals; Binding, Competitive; Cerebral Cortex; Drug Synergism; Flunitrazepam; GABA Modulators; Glycosides; Hypnotics and Sedatives; Indenes; Magnetic Resonance Spectroscopy; Male; Plant Extracts; Rats; Rats, Wistar; Sesquiterpenes; Sleep; Spectrophotometry, Ultraviolet; Synaptosomes; Thiopental; Valerian

2004