thiopental and cyclopropane

Histamine release is part of the general inflammatory response and occurs during surgery and cardiopulmonary bypass (CPB) in adults. Few data are available for children. Histamine release was studied in 23 children undergoing CPB with standard anaesthetic and CPB techniques. Blood sampling was performed in relation to specific anaesthetic and surgical events, e.g., start of CPB, removal of aortic clamps, reventilation of the lungs. Plasma histamine was determined by a single isotope radioenzymatic technique. There was no consistent histamine release in the study population although there was an increase in plasma histamine concentration in some subjects after initiation of CPB (P < 0.05) and on removal of the aortic cross-clamp (P < 0.05). No correlation was demonstrated between histamine concentration and systolic arterial pressure, temperature, duration of CPB or cross-clamp time. Histamine concentration was positively correlated with heart rate.

Topics: Adolescent; Anesthesia, General; Anesthetics; Blood Pressure; Body Temperature; Cardiopulmonary Bypass; Child; Child, Preschool; Cyclopropanes; Heart Arrest, Induced; Heart Defects, Congenital; Heart Rate; Heparin; Histamine; Histamine Release; Humans; Infant; Protamines; Respiration, Artificial; Thiopental; Time Factors

Topics: Alanine Transaminase; Anesthesia; Anesthesia, Inhalation; Chemical and Drug Induced Liver Injury; Cholinesterases; Clinical Enzyme Tests; Cyclopropanes; Diagnosis; Fluids and Secretions; Halothane; Hepatitis; Liver Function Tests; Preanesthetic Medication; Statistics as Topic; Thiopental; Toxicology; Urine; Urobilinogen

Topics: Anesthetics; Chloroform; Cyclopropanes; Ether; Ethers; Halothane; Hypoxia; Methoxyflurane; Mice; Nitrous Oxide; Pharmacology; Research; Thiopental; Trichloroethylene

Topics: Anesthesia; Blood Circulation; Blood Pressure; Capillaries; Cyclopropanes; Ether; Halothane; Hematocrit; Humans; Methoxyflurane; Microcirculation; Morphine; Pathology; Pentobarbital; Shock, Hemorrhagic; Shock, Traumatic; Thiopental; Toxicology; Wounds and Injuries

Topics: Acidosis; Anesthesia; Anesthesia, General; Anesthesia, Spinal; Anesthetics; Barbiturates; Blood Circulation; Blood Pressure; Blood Volume; Cyclopropanes; Ether; Halothane; Heart; Humans; Methoxyflurane; Muscle Relaxants, Central; Pharmacology; Respiration; Thiopental

Topics: Anesthesia; Anesthesia, Inhalation; Animals; Biomedical Research; Blood Volume; Blood Volume Determination; Cardiac Output; Chloroform; Cyclopropanes; Dogs; Dye Dilution Technique; Halothane; Heart Function Tests; Oximetry; Research; Surgical Procedures, Operative; Thiopental

Topics: Alanine Transaminase; Alkaline Phosphatase; Anesthesia; Anesthesia, General; Aspartate Aminotransferases; Bilirubin; Blood Proteins; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Cyclopropanes; Ethers; Halothane; Hepatitis; Hepatitis A; Liver Diseases; Liver Function Tests; Retrospective Studies; Statistics as Topic; Thiopental; Thymol; Toxicology; Trichloroethylene; Zinc

Topics: Anesthesia; Anesthesia, Endotracheal; Anesthesia, General; Anesthesia, Inhalation; Anesthesia, Local; Anesthesia, Spinal; Child; Cyclopropanes; Ethanol; Ether; Ethers; Halothane; Humans; Infant; Infant, Newborn; Kidney; Liver; Metabolism; Nitrous Oxide; Physiology; Preanesthetic Medication; Respiratory System; Thiopental; Trichloroethylene

Topics: Anesthesia; Blood Proteins; Blood Viscosity; Cyclopropanes; Equipment and Supplies; Erythrocytes; Halothane; Hematocrit; Heparin; Humans; Hypothermia; Norepinephrine; Pharmacology; Plasma; Thiopental

Topics: Anesthetics; Cholinesterases; Curare; Cyclopropanes; Drug Therapy; Ethers; Gallamine Triethiodide; Halothane; Humans; Kidney Transplantation; Kidneys, Artificial; Succinylcholine; Thiopental; Vasopressins

Topics: Anesthesia; Anesthesia, General; Anesthesia, Spinal; Bronchitis; Cyclopropanes; Ether; Halothane; Hernia, Inguinal; Meperidine; Muscle Relaxants, Central; Nausea; New York; Nitrous Oxide; Pneumonia; Postoperative Complications; Respiratory Tract Infections; Surgical Procedures, Operative; Thiopental; Toxicology; Urinary Catheterization; Vomiting

Topics: Acid-Base Equilibrium; Anesthesia; Anesthesia, Obstetrical; Anesthesia, Spinal; Cyclopropanes; Female; Fetus; Humans; Infant, Newborn; Maternal-Fetal Exchange; Mothers; Pharmacology; Pregnancy; Thiopental

Topics: Arrhythmias, Cardiac; Cyclopropanes; Dogs; Drug Synergism; Electrocardiography; Epinephrine; Pharmacology; Research; Thiopental; Toxicology

Topics: Anesthesia; Anesthesia, Obstetrical; Anesthesiology; Atropine; Cesarean Section; Cyclopropanes; Female; Humans; Pregnancy; Succinylcholine; Thiopental

Topics: Anesthesia; Anesthetics; Blood Flow Velocity; Blood Pressure; Cardiac Output; Chloroform; Cyclopropanes; Dye Dilution Technique; Halothane; Heart Function Tests; Heart Rate; Humans; Nitrous Oxide; Pharmacology; Pulse; Thiopental

Topics: Anesthesia; Anesthesia, General; Anesthesia, Inhalation; Asphyxia Neonatorum; Barbiturates; Cesarean Section; Cyclopropanes; Ether; Female; Humans; Infant Mortality; Infant, Newborn; Muscle Relaxants, Central; Nitrous Oxide; Pregnancy; Thiopental; Toxicology

Topics: Anesthesia; Arteries; Blood Circulation; Cyclopropanes; Ether; Halothane; Humans; Meperidine; Scopolamine; Succinylcholine; Thiopental; Tubocurarine

Topics: Anesthesia; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthesiology; Atropine; Child; Cyclopropanes; Emergencies; Gallamine Triethiodide; Humans; Infant; Infant, Newborn; Pediatrics; Preanesthetic Medication; Thiopental

Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Ballistocardiography; Blood Circulation; Cyclopropanes; Thiopental

Topics: Animals; Barbiturates; Cyclopropanes; Ether; Rats; Shock; Thiopental

Topics: Anesthesia; Barbiturates; Cardiac Output; Cyclopropanes; Ether; Heart; Humans; Oximetry; Oxygen; Thiopental

Topics: Animals; Barbiturates; Cyclopropanes; Dogs; Ether; Ethers; Heart; Hydrogen-Ion Concentration; Nitrous Oxide; Thiopental

Topics: Barbiturates; Curare; Cyclopropanes; Ether; Ethers; Ganglia; Ganglia, Autonomic; Thiopental; Tubocurarine

Topics: Anesthesia; Anesthesia, Inhalation; Arrhythmias, Cardiac; Barbiturates; Cyclopropanes; Ether; Humans; Nitrous Oxide; Thiopental

Topics: Anesthesia; Barbital; Chemical and Drug Induced Liver Injury; Cyclopropanes; Electrolytes; Ether; Glomerular Filtration Rate; Humans; Kidney; Liver; Thiopental

Topics: Anesthetics, General; Barbital; Cyclopropanes; Ether; Ethers; Heart Rate; Humans; Myocardial Contraction; Thiopental

Topics: Anesthesia; Anesthesia, Spinal; Cyclopropanes; Humans; Kidney; Liver; Male; Thiopental

Topics: Anesthesia; Cyclopropanes; Humans; Nitrous Oxide; Oxygen; Thiopental