thioinosine and cyclopentanone

thioinosine has been researched along with cyclopentanone* in 1 studies

Other Studies

1 other study(ies) available for thioinosine and cyclopentanone

Article	Year
Synthesis using ring closure metathesis and effect on nucleoside transport of a (N)-methanocarba S-(4-nitrobenzyl)thioinosine derivative. Organic letters, 2001, Feb-22, Volume: 3, Issue:4 [reaction: see text] A new synthetic route to ring-constrained (N)-methanocarba nucleosides and nucleotides is presented. Ring closure of a diene intermediate using Grubbs catalyst provides a new avenue for the preparation of the cyclopentenone derivative 6, which is a versatile intermediate for various carbocycles. The product was almost as potent an inhibitor of es-mediated nucleoside transport as the parent compound, inhibiting initial rates of uptake of uridine into cultured CCRF-CEM cells by 50% at approximately 30-50 nM. Topics: Biological Transport; Catalysis; Cells, Cultured; Cyclization; Cyclopentanes; Humans; Molecular Structure; Nucleotides; Structure-Activity Relationship; Thioinosine	2001

Article

Year

Synthesis using ring closure metathesis and effect on nucleoside transport of a (N)-methanocarba S-(4-nitrobenzyl)thioinosine derivative.

Organic letters, 2001, Feb-22, Volume: 3, Issue:4

[reaction: see text] A new synthetic route to ring-constrained (N)-methanocarba nucleosides and nucleotides is presented. Ring closure of a diene intermediate using Grubbs catalyst provides a new avenue for the preparation of the cyclopentenone derivative 6, which is a versatile intermediate for various carbocycles. The product was almost as potent an inhibitor of es-mediated nucleoside transport as the parent compound, inhibiting initial rates of uptake of uridine into cultured CCRF-CEM cells by 50% at approximately 30-50 nM.

Topics: Biological Transport; Catalysis; Cells, Cultured; Cyclization; Cyclopentanes; Humans; Molecular Structure; Nucleotides; Structure-Activity Relationship; Thioinosine

2001