thiohydantoins and phenalen-1-one

Thiohydantoin and quinolone derivatives have attracted researchers' attention because of a broad spectrum of their medical applications. The aim of our research was to synthesize and analyze the antimicrobial properties of novel 2-thiohydantoin and 2-quinolone derivatives. For this purpose, two series of hybrid compounds were synthesized. Both series consisted of 2-thiohydantoin core and 2-quinolone derivative ring, however one of them was enriched with an acetic acid group at N3 atom in 2-thiohydantoin core. Antibacterial properties of these compounds were examined against bacteria:

Topics: Anti-Bacterial Agents; Antifungal Agents; Gram-Negative Bacteria; Gram-Positive Bacteria; Light; Microbial Sensitivity Tests; Molecular Structure; Phenalenes; Pseudomonas aeruginosa; Quinolones; Structure-Activity Relationship; Thiohydantoins