thioguanine-anhydrous and methylnitrosocyanamide

thioguanine-anhydrous has been researched along with methylnitrosocyanamide* in 1 studies

Other Studies

1 other study(ies) available for thioguanine-anhydrous and methylnitrosocyanamide

Article	Year
Chromosomal aberration, mutation and morphological transformation of Syrian hamster embryonic cells after exposure to methylnitrosocyanamide. Mutation research, 1977, Volume: 43, Issue:3 Hamster embryonic fibroblasts were treated directly with various concentrations of methylnitrosocyanamide (MNC), a nitrosated product of methylguanidine (MG) or N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Then they were examined for chromosomal aberrations, morphological transformation and mutations resistant to 8-azaguanine (8AG) and 6-thioguanine (6TG). Direct treatment with 2 to 10 X 10(-6) M MNC caused a marked, dose-dependent appearance of 8AG- and 6TG-resistant mutations. The ability of MNC to induce mutations was similar to that of MNNG. Cultured embryonic fibroblasts in metaphase plates also showed a marked dose-dependent increase in chromosomal aberrations within 24 h after direct treatment with MNC or MNNG. Moreover, MNC and MNNG caused similar rates of morphological transformation. Topics: Animals; Azaguanine; Cell Line; Cell Transformation, Neoplastic; Chromosome Aberrations; Chromosomes; Cricetinae; Dose-Response Relationship, Drug; Drug Resistance; Guanidines; Mesocricetus; Methylguanidine; Methylnitronitrosoguanidine; Mutation; Nitrosamines; Thioguanine	1977

Article

Year

Chromosomal aberration, mutation and morphological transformation of Syrian hamster embryonic cells after exposure to methylnitrosocyanamide.

Mutation research, 1977, Volume: 43, Issue:3

Hamster embryonic fibroblasts were treated directly with various concentrations of methylnitrosocyanamide (MNC), a nitrosated product of methylguanidine (MG) or N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Then they were examined for chromosomal aberrations, morphological transformation and mutations resistant to 8-azaguanine (8AG) and 6-thioguanine (6TG). Direct treatment with 2 to 10 X 10(-6) M MNC caused a marked, dose-dependent appearance of 8AG- and 6TG-resistant mutations. The ability of MNC to induce mutations was similar to that of MNNG. Cultured embryonic fibroblasts in metaphase plates also showed a marked dose-dependent increase in chromosomal aberrations within 24 h after direct treatment with MNC or MNNG. Moreover, MNC and MNNG caused similar rates of morphological transformation.

Topics: Animals; Azaguanine; Cell Line; Cell Transformation, Neoplastic; Chromosome Aberrations; Chromosomes; Cricetinae; Dose-Response Relationship, Drug; Drug Resistance; Guanidines; Mesocricetus; Methylguanidine; Methylnitronitrosoguanidine; Mutation; Nitrosamines; Thioguanine

1977