thioguanine-anhydrous has been researched along with 9-10-dihydroxy-7-8-epoxy-7-8-9-10-tetrahydro-3-methylcholanthrene* in 1 studies
1 other study(ies) available for thioguanine-anhydrous and 9-10-dihydroxy-7-8-epoxy-7-8-9-10-tetrahydro-3-methylcholanthrene
| Article | Year |
|---|---|
On the mechanism of induction of resistance to 6-thioguanine in Chinese hamster V79 cells by 3-methylcholanthrene-diolepoxide.
V79 Chinese hamster cells were cultured in the presence of 3-methylcholanthrene-diolepoxide (10r,9t-dihydroxy-7,8t-epoxy-tetrahydro-3-methylcholanthrene, MCDE) and mutants were selected in medium containing 6-thioguanine (TG). Of 22 TG-resistant mutants examined, 18 were devoid of HPRT (hypoxanthine-guanine phosphoribosyltransferase, EC 2.4.2.8) activity. Two mutants had suffered a total and one a partial gene deletion. The 1.6-kb HPRT mRNA was not detected in these three mutants nor in two others. The remaining mutants did not, however, have a readily demonstrable lesion. Topics: Animals; Carcinogens; Cells, Cultured; Cricetinae; Cricetulus; DNA; DNA Restriction Enzymes; Drug Resistance; Genes; Hypoxanthine Phosphoribosyltransferase; Isoelectric Point; Methylcholanthrene; Mutation; RNA, Messenger; Thioguanine | 1985 |