thioflavin t has been researched along with thiazoles in 1308 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (2.60) | 18.7374 |
| 1990's | 73 (5.58) | 18.2507 |
| 2000's | 514 (39.30) | 29.6817 |
| 2010's | 687 (52.52) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bouras, C; Guntern, R; Hof, PR; Vallet, PG | 1 |
| Bouras, C; Delacourte, A; Golaz, J; Guntern, R; Hof, PR; Robakis, NK; Vallet, PG | 1 |
| Cerwinski, S; Chou, SJ; Emory, C; Fisher, GH; Frey, WH; Man, EH; Martin, T; Payan, IL | 1 |
| Van Hoesen, GW; Vogt, BA; Vogt, LJ | 1 |
| Davous, P; Fallet-Bianco, C; Lamour, Y; Roudier, M; Senut, MC | 2 |
| Altman, NH; Brunnert, SR | 1 |
| Benes, FM; Bird, ED; Farol, PA; Majocha, RE; Marotta, CA | 1 |
| Davous, P; Fallet-Bianco, C; Lamour, Y; Roudier, M | 1 |
| Chen, WH; Higuchi, K; Hosokawa, M; Matsushima, K; Naiki, H; Shimada, A; Takeda, T | 1 |
| Egginton, S; Hargreaves, D; Hudlická, O | 1 |
| Aalto, ML; Collan, Y; Jantunen, E; Karhunen, J; Kosma, VM; Kulju, T; Selkäinaho, K | 1 |
| Chen, CH; Chiu, LA; Lee, LG | 1 |
| German, DC; Saper, CB | 1 |
| Defossez, A; Delacourte, A; Peers, MC; Persuy, P | 1 |
| Défossez, A; Delacourte, A | 1 |
| Ashworth, J; Auböck, J; Booker, J; Breathnach, SM; Hintner, H; Pepys, MB | 1 |
| Brion, JP; Delaère, P; Duyckaerts, C; Hauw, JJ; Poulain, V | 1 |
| Behrouz, N; Defossez, A; Delacourte, A; Hublau, P; Mazzuca, M | 1 |
| Boddie, NT; Nickerson, SC; Saxton, AM; Sordillo, LM | 1 |
| Jungalwala, FB; Majocha, RE; Marotta, CA; Rodenrys, A | 1 |
| Ackerman, NB; Bloom, ND; Jacobs, R; Kroop, EN | 1 |
| Défossez, A; Delacourte, A; Lenders, MB; Mazzuca, M; Peers, MC | 1 |
| Brew, E; Corash, L; Lieu, S; Meers, P; Rheinschmidt, M | 1 |
| KuKuruga, D; Palutke, M; Roher, A; Wolfe, D | 1 |
| Charache, S; Metzger, DK | 1 |
| Cañete, M; Juarranz, A; Stockert, JC; Villanueva, A | 1 |
| Gilroy, J; LeWitt, P; Pomara, N; Reitz, D; Townsend, LE; Weintraub, J; Wolfe, DE | 1 |
| Nickerson, SC; Sordillo, LM | 1 |
| Kanaide, H; Nakamura, M; Taira, Y | 1 |
| German, DC; Saper, CB; White, CL | 1 |
| Canioni, D; Kermarec, J | 1 |
| Eckert, H | 1 |
| Mercolino, TJ; O'Connell, JP; Sage, BH | 1 |
| Kornblith, PL; McKeever, PE; Oberc-Greenwood, MA; Smith, BH | 1 |
| Glogar, D; Mayr, H; Mohl, W; Sochor, H; Weber, H | 1 |
| Date, A; Neela, P; Shastry, JC | 1 |
| Kawahara, M; Kobayashi, K; Kuroda, Y; Mori, H; Muramoto, K | 1 |
| Arendt, T; Bigl, V; Brückner, MK; Marcova, L | 1 |
| Link, CD | 1 |
| Biernat, J; Mandelkow, E; Mandelkow, EM; Schweers, O | 1 |
| Buée, L; Buée-Scherrer, V; Delacourte, A; Marugg, RA; Morrison, JH; Riederer, BM; Vickers, JC | 1 |
| O'Barr, S; Rogers, J; Webster, S | 1 |
| Baskin, DG; D'Alessio, DA; Ensinck, JW; Hoagland, V; Kahn, SE; Palmiter, RD; Verchere, CB | 1 |
| Greenberg, SG; Nelson, PT; Saper, CB | 1 |
| Aimi, Y; Kawamata, T; McGeer, EG; McGeer, PL; Yasuhara, O | 1 |
| Cotman, CW; Cummings, BJ; Su, JH | 1 |
| Arai, M; Fraser, P; Kimata, K; Mizutani, A; Morgan, DG; Nochlin, D; Schreier, WA; Sekiguchi, R; Snow, AD | 1 |
| Meiners, KA; Rhodes, KJ; Rosene, DL | 1 |
| LeVine, H | 4 |
| Gómez-Ramos, P; Morán, MA; Navarro, C; Probst, A | 1 |
| Alvarez, A; Casanueva, OI; Garrido, J; Inestrosa, NC; Linker, C; Moreno, RD; Pérez, CA; Soto, C; Vicente, M | 1 |
| Naukkarinen, A; Paljärvi, L; Repo, LP; Teräsvirta, ME | 1 |
| Naiki, H; Nakakuki, K | 1 |
| Audia, JE; Drzewiecki, GJ; Fuson, K; Hyslop, PA; May, PC; Rydel, RE; Wogulis, M; Wright, S; Zhang, Z | 1 |
| Rogers, J; Webster, S | 1 |
| Bubb, MR; Caviston, TL; DeTure, MA; Erdos, GW; Purich, DL; Whittaker, SD; Zhang, EY | 1 |
| Beavis, RC; Frangione, B; Golabek, A; Lalowski, M; Lemere, CA; Selkoe, DJ; Wisniewski, HM; Wisniewski, T | 1 |
| Hansen, LA; Mallory, M; Masliah, E; Vincent, I; Wakabayashi, K | 1 |
| Cunningham, AM; Hipkiss, AR; Mayer, S; Michaelis, J; Müller, R; Münch, G; Neumann, A; Riederer, P; Schinzel, R | 1 |
| Andersson, K; Baranov, V; Dacklin, I; Edvinsson, A; Goldsteins, G; Hammarstrom, S; Lundgren, E; Olofsson, A; Sandgren, O; Thylén, C | 1 |
| Morrison, JH; Sampson, VL; Vickers, JC | 1 |
| Bradt, B; Cooper, N; Rogers, J; Webster, S | 1 |
| Brown, AM; Hofmann, JR; Jacobsen, JS; Rhodes, KJ; Sonnenberg-Reines, J; Tummolo, DM | 1 |
| Johnson-Wood, K; Lin, C; Mallory, M; Masliah, E; McConlogue, L; Mucke, L; Wyss-Coray, T | 1 |
| Exley, C | 1 |
| Guillozet, AL; Mash, DC; Mesulam, MM; Smiley, JF | 1 |
| Melchor, JP; Ruffini, L; Van Nostrand, WE | 1 |
| Altermatt, HJ; Laeng, RH; Scheithauer, BW; Zimmermann, DR | 1 |
| Crutcher, KA; Joshi, SN | 1 |
| Cataldo, AM; Imahori, K; Ishiguro, K; Nixon, RA; Shiurba, RA; Spooner, ET; Takahashi, M; Wheelock, TR; Yoshida, R | 1 |
| Honda, K; Horita, S; Nihei, H; Nitta, K; Yumura, W | 1 |
| Goyal, S; Heroux, J; Hughes, SR; Khorkova, O; Knaeblein, J; Riedel, NG; Sahasrabudhe, S | 1 |
| Eriksson, S; Gerbod, MC; Janciauskiene, S; Jeppsson, JO | 1 |
| Crutcher, KA; Scott, SA; Tolar, M | 1 |
| Beal, MF; Kowall, NW; McKee, AC; Schumacher, JS | 1 |
| Alvarez, A; Bronfman, FC; Inestrosa, NC; Morgan, C | 1 |
| Butler, PC; Eberhardt, NL; Kudva, YC; Mueske, C | 1 |
| Castillo, GM; Cummings, JA; Hansen, JB; Judge, ME; Rimvall, K; Sheardown, MJ; Snow, AD; Yang, W | 1 |
| Geula, C; Mesulam, MM; Saroff, DM; Wu, CK | 1 |
| Friedhoff, P; Mandelkow, E; Mandelkow, EM; Schneider, A | 1 |
| Hashimoto, M; Hsu, LJ; Masliah, E; Sisk, A; Sundsmo, M; Takeda, A; Xia, Y | 1 |
| Balass, M; Frenkel, D; Solomon, B | 1 |
| Hayashi, Y; Monji, A; Tashiro, K; Tashiro, N; Yoshida, I | 1 |
| Nandi, PK | 1 |
| Becker, LC; Bluemke, DA; Kim, RJ; Lima, JA; Rochitte, CE; Wu, KC; Zerhouni, EA | 1 |
| Beffert, U; Poirier, J | 1 |
| Curran, MD; El-Agnaf, OM; Jakes, R; Wallace, A | 1 |
| Bianchi, E; Curran, MD; El-Agnaf, OM; Ingenito, R; Jakes, R; Middleton, D; Neill, D; Pessi, A; Wallace, A | 1 |
| Agianian, B; Becker, PB; Bonte, E; Leonard, K; Tucker, PA; Van der Zandt, H | 1 |
| Fuson, KS; Mark, RJ; May, PC | 1 |
| Chiti, F; Clark, A; Dobson, CM; Ramponi, G; Stefani, M; Taddei, N; Webster, P | 1 |
| Dickson, DW; Lee, VM; Trojanowski, JQ; Wang, J | 1 |
| Boelens, WC; Bosman, GJ; de Jong, WW; Overkamp, PS; Reijnen-Aalbers, A; Renkawek, K; Stege, GJ; van Rijk, AF; Verschuure, P | 1 |
| Johnson, KH; Westermark, GT; Westermark, P | 1 |
| Murphy, CL; Solomon, A; Wall, J | 1 |
| Solomon, A; Wall, J | 1 |
| Gejyo, F; Hashimoto, N; Naiki, H | 1 |
| Conway, KA; Ding, TT; Lansbury, PT; Lee, SJ; Rochet, JC; Williamson, RE | 1 |
| Bales, KR; Fagan, AM; Holtzman, DM; Mackey, B; McKeel, D; Olney, J; Parsadanian, M; Paul, SM; Sartorius, LJ; Tenkova, T; Wozniak, D | 1 |
| Conway, KA; Harper, JD; Lansbury, PT | 1 |
| Akhtar, NJ; Liang, JJ; Sun, TX | 1 |
| Isobe, I; Michikawa, M; Yanagisawa, K | 1 |
| Clark, A; Fraser, PE; Gross, M; Higham, CE; Jaikaran, ET | 1 |
| Chu, CC; Parvizi, J; Van Hoesen, GW | 1 |
| Dagø, L; Olesen, OF | 1 |
| Burke, RM; Doig, AJ; Hughes, E | 1 |
| Boeddrich, A; Heiser, V; Lehrach, H; Lurz, R; Nordhoff, E; Scherzinger, E; Schugardt, N; Wanker, EE | 1 |
| Amoresano, A; Bellotti, V; Dal Piaz, F; Esposito, G; Ferri, G; Hernández, H; Mangione, P; Merlini, G; Michelutti, R; Monti, M; Pucci, P; Robinson, CV; Stoppini, M; Verdone, G; Viglino, P | 1 |
| Hatters, DM; Howlett, GJ; Lawrence, LJ; MacPhee, CE; Sawyer, WH | 1 |
| Merkel, JS; Ramirez-Alvarado, M; Regan, L | 1 |
| Brown, A; Hunter, MG; Kad, NM; Kalverda, AP; Kirwin-Jones, P; McParland, VJ; Radford, SE; Sunde, M | 1 |
| Farer, M; Hardy, J; Lee, JM; Ostrerova-Golts, N; Petrucelli, L; Wolozin, B | 1 |
| Aebi, U; Frey, P; Goldsbury, CS; Müller, SA; Sunderji, S; Wicki, P; Wirtz, S | 1 |
| Blondelle, SE; Crooks, E; Houghten, RA; Ostresh, JM; Reixach, N | 1 |
| Aebi, U; Cooper, GJ; Frey, P; Goldie, K; Goldsbury, C; Kistler, J; Müller, SA; Pellaud, J; Seelig, J | 1 |
| Hamilton, RL; Klunk, WE; Styren, GC; Styren, SD | 1 |
| Frederikse, PH | 1 |
| Kang, WH; Kim, JH; Yim, H | 1 |
| Ackmann, M; Barghorn, S; Biernat, J; Mandelkow, E; Mandelkow, EM; von Bergen, M; Zheng-Fischhöfer, Q | 1 |
| Damas, AM; Merlini, G; Saraiva, MJ; Sebastião, MP | 1 |
| Castillo, GM; Kirschner, DA; Lukito, W; Peskind, E; Raskind, M; Snow, AD; Yee, AG | 1 |
| Liang, JJ | 1 |
| Bacskai, BJ; Christie, RH; Hyman, BT; Kajdasz, ST; Webb, WW; Williams, RM; Zipfel, WR | 1 |
| Anderton, BH; Ayling, H; Frangione, B; Ghiso, J; Gibb, G; Guerin, CJ; Holton, JL; Houlden, H; Lashley, T; Martinian, L; Plant, G; Revesz, T; Rostagno, A; Vidal, R; Wood, NW | 1 |
| Buford, JP; Butko, P; Cannon, GC; Goodwin, JS; McCormick, CL; Stroud, PA | 1 |
| Colombo, L; Forloni, G; Girola, L; Salmona, M; Tagliavini, F | 1 |
| Azizeh, BY; Cotman, CW; Cribbs, DH; Head, E; Lott, IT; Tenner, AJ | 1 |
| De Ferrari, GV; Inestrosa, NC; Mallender, WD; Rosenberry, TL | 1 |
| Clark, A; Fraser, PE; Gross, M; Higham, CE; Jaikaran, ET; Serpell, LC; Zurdo, J | 1 |
| Hashioka, S; Monji, A; Tashiro, K; Tashiro, N; Utsumi, H; Yoshida, I | 1 |
| Brange, J; Coats, A; Fink, AL; Frokjaer, S; Khurana, R; Nielsen, L; Uversky, VN; Vyas, S | 1 |
| Exley, C; Korchazhkina, OV | 2 |
| Hashioka, S; Imoto, T; Monji, A; Tashiro , K; Tashiro, N; Ueda, T; Utsumi, H; Yoshida, I | 1 |
| Bauer, R; Carrotta, R; Rischel, C; Waninge, R | 1 |
| Duff, K; La Francois, J; Matsuoka, Y; Picciano, M | 1 |
| Gordon, DJ; Meredith, SC; Sciarretta, KL | 1 |
| Carver, JA; Hatters, DM; Howlett, GJ; Lindner, RA | 1 |
| Chung, KC; Kim, J; Kim, YS; Lee, D; Lee, EK; Paik, SR; Sung, JY | 1 |
| Bales, KR; Cummins, DJ; DeLong, CA; Esterman, MA; Fishman, CE; Hanson, JC; Jordan, WH; Paul, SM; White, SL | 1 |
| Dickson, TC; Vickers, JC | 1 |
| Cruz, L; Duff, K; Hsiao-Ashe, K; Hyman, BT; Irizarry, MC; Knowles, RB; Le, R; Stanley, HE; Urbanc, B | 1 |
| Radford, SE; Smith, DP | 1 |
| Cummins, DJ; Paul, SM; Qiao, X | 1 |
| Debnath, ML; Holt, DP; Huang, GF; Klunk, WE; Mathis, CA; Wang, Y | 1 |
| Bellotti, V; Caccialanza, G; Chiti, F; De Lorenzi, E; Dobson, CM; Giorgetti, S; Grossi, S; Mangione, P; Merlini, G; Ramponi, G | 1 |
| Emson, PC; Iritani, S; Niizato, K | 1 |
| Goto, Y; Hagihara, Y; Hasegawa, K; Kawakami, T; Kozhukh, GV; Naiki, H | 1 |
| Borowska-Lehman, J; Gross, M; Izycka-Swieszewska, E; Rzepko, R; Zółtowska, A | 1 |
| Bucciantini, M; Capanni, C; Chiti, F; Dobson, CM; Stefani, M; Taddei, N | 1 |
| Akagi, T; Hashikawa, T; Kikuchi, N; Matsuda, K; Murayama, M; Murayama, O; Nakao, S; Park, JM; Sato, S; Sun, X; Takashima, A; Tanemura, K; Yamaguchi, H; Yoshiike, Y | 1 |
| Mallory, M; Mante, M; Masliaha, E; Rockenstein, E; Sisk, A | 1 |
| Hatters, DM; Howlett, GJ; Minton, AP | 1 |
| Ciani, B; Hutchinson, EG; Sessions, RB; Woolfson, DN | 1 |
| Akikusa, S; Kodaka, M; Konakahara, T; Nakamura, K; Okada, T; Okuno, H; Watanabe, K | 1 |
| Baroni, F; Capanni, C; Chiti, F; Dobson, CM; Ramponi, G; Stefani, M; Taddei, N | 1 |
| Bacskai, BJ; Debnath, ML; Frosch, MP; Holt, DP; Huang, GF; Hyman, BT; Kajdasz, ST; Klunk, WE; Mathis, CA; McLellan, ME; Wang, Y | 1 |
| Musevic, I; Pompe-Novak, M; Ravnikar, M; Skarabot, M; Turk, V; Zerovnik, E | 1 |
| Mihara, H; Takahashi, Y; Ueno, A | 2 |
| Geula, C; Nagykery, N; Wu, CK | 1 |
| Balaban, TS; Greferath, R; Hopkins, RJ; Lazarte, JE; Nicolau, C | 1 |
| Anderton, BH; Ayling, H; Bojsen-Møller, M; Braendgaard, H; Frangione, B; Ghiso, J; Gibb, G; Guerin, CJ; Hanger, DP; Holton, JL; Lashley, T; Plant, G; Revesz, T; Rostagno, A; Strand, C; Vidal, R | 1 |
| Fukushima, K; Isobe, Y; Kiuchi, Y | 1 |
| Bose, S; Gu, Y; Kalepu, S; Mishra, RS; Singh, N; Verghese, S | 1 |
| Bing, G; Nguyen, XV; Sun, A | 1 |
| Corboy, MJ; Cutler, TD; Hunt, JF; Lee, MG; Oldan, J; Rizo, J; Thibodeau, PH; Thomas, PJ; Wigley, WC | 1 |
| Goto, Y; Gozu, M; Hasegawa, K; Hong, DP; Naiki, H | 1 |
| Carpenter, JF; Kim, YS; Randolph, TW; Stevens, FJ | 1 |
| Aksenova, M; Butterfield, DA; Kanski, J; Schöneich, C | 1 |
| Berthelier, V; Chen, S; Hamilton, JB; O'Nuallain, B; Wetzel, R | 1 |
| Easterbrook-Smith, SB; Hatters, DM; Howlett, GJ; Wilson, MR | 1 |
| Irie, K; Morimoto, A; Murakami, K; Nagao, M; Ohigashi, H; Shimizu, T; Shindo, M; Shirasawa, T | 1 |
| Cherny, DI; Heim, G; Jovin, TM; Pavlov, NA; Subramaniam, V | 1 |
| Hasegawa, K; Naiki, H; Ono, K; Takashima, A; Yamada, M; Yoshiike, Y | 3 |
| Duda, JE; Giasson, BI; Golbe, LI; Lee, VM; Mabon, ME; Miller, DC; Trojanowski, JQ | 1 |
| Borchelt, DR; Coonfield, M; Copeland, NG; Fromholt, D; Gonzales, V; Jenkins, NA; Wang, J; Xu, G | 1 |
| Ando, Y; Haraoka, K; Hashimoto, M; Hata, K; Imasato, A; Ishizaki, T; Kai, H; Kamide, K; Nakagawa, K; Nakamura, M; Okabe, H; Tajiri, T; Takechi, K; Terazaki, H; Yamashita, T | 1 |
| Murasugi, T; Oda, T; Tokuhiro, S; Uryu, S | 1 |
| Aronow, BJ; Bales, KR; DeMattos, RB; Harmony, JA; Holtzman, DM; O'dell, MA; Parsadanian, M; Paul, SM; Taylor, JW | 1 |
| Fukushima, K; Isobe, Y; Kimura, M; Kiuchi, Y | 1 |
| Fujita, T; Kakizuka, A; Kimura, Y; Koitabashi, S | 1 |
| Aggarwal, A; Balakhaneh, D; Callaway, DJ; Hartley, DM; Lashuel, HA; Teichberg, S | 1 |
| Kloner, RA; Reffelmann, T | 1 |
| Boyd, RE; Chen, R; Conway, KA; Lee, DH; Luo, C; Nortey, SO; Parker, MH; Reitz, AB; Ross, TM; Scott, MK | 1 |
| Leclerc, E; Nandi, PK; Nicole, JC; Takahashi, M | 1 |
| Antony, T; Cherny, D; Heim, G; Hoyer, W; Jovin, TM; Subramaniam, V | 1 |
| Bacskai, BJ; Games, D; Hyman, BT; Kajdasz, ST; McLellan, ME; Schenk, D; Seubert, P | 1 |
| Ikkala, O; Linder, M; Serimaa, R; Torkkeli, M | 1 |
| Cashman, NR; Chakrabartty, A; Crow, JP; Cunningham, P; Dahan, S; Furtos-Matei, A; Kondejewski, LH; Qi, XF; Rakhit, R | 1 |
| Capsoni, S; Cattaneo, A; Giannotta, S | 1 |
| Ashe, KH; Cruz, L; Duff, K; Hyman, BT; Irizarry, MC; Le, R; Sanders, J; Stanley, HE; Urbanc, B | 1 |
| Argilés, A; Arnaud, B; Calas, B; Chavanieu, A; Demaille, JG; Herrada, G; Schmitt-Bernard, CF; Subra, G | 1 |
| Allen, B; Atzori, C; Craxton, M; Crowther, RA; Emson, PC; Ghetti, B; Goedert, M; Holzer, M; Ingram, E; Jakes, R; Migheli, A; Smith, MJ; Spillantini, MG; Takao, M; Virdee, K; Yoshida, H | 1 |
| Cottingham, MG; Hollinshead, MS; Vaux, DJ | 1 |
| Signor, L; Staab, D; Staufenbiel, M; Stoeckli, M; Wiederhold, KH | 1 |
| Hou, C; Kung, HF; Kung, MP; Lee, VM; Skovronsky, D; Trojanowski, JQ; Zhang, B; Zhuang, ZP | 1 |
| Choi, SY; Kang, JH; Kang, TC; Kim, KS; Kwon, HY; Won, MH | 1 |
| Bottomley, SP; Chow, MK; Devlin, GL; Howlett, GJ | 1 |
| Borowski, BJ; Curran, GL; Jack, CR; Macura, SI; Poduslo, JF; Sigurdsson, EM; Wengenack, TM; Wisniewski, T | 1 |
| Gordon, DJ; Meredith, SC | 1 |
| Cardoso, I; Damas, AM; Fayard, B; Gales, L; Quintanilha, A; Saraiva, MJ | 1 |
| Harkany, T; Härtig, W; Kacza, J; Paulke, BR; Seeger, J; Varga, C | 1 |
| Bacskai, BJ; D'Amore, JD; Hyman, BT; Kajdasz, ST; McLellan, ME; Stern, EA | 1 |
| Chao, PC; Jan, FJ; Kathir, KM; Kumar, TK; Rajalingam, D; Sheu, HS; Srisailam, S; Yu, C | 1 |
| Cocco, MJ; Ramírez-Alvarado, M; Regan, L | 1 |
| Fink, AL; Munishkina, LA; Phelan, C; Uversky, VN | 1 |
| Bernhagen, J; Buck, A; Hirsch, T; Kapurniotu, A; Schmauder, A; Tatarek-Nossol, M; Weber, M | 1 |
| DiGiammarino, EL; Galea, C; Jun, B; Kriwacki, RW; Lee, AS; Murti, G; Ribeiro, RC; Schultz, CP; Zambetti, G | 1 |
| Ban, T; Goto, Y; Hamada, D; Hasegawa, K; Naiki, H | 1 |
| Bacskai, BJ; Hyman, BT; Kajdasz, ST; McLellan, ME | 1 |
| Dickson, TC; Tan, A; Vickers, JC | 1 |
| Akagi, T; Chui, DH; Takashima, A; Tanaka, N; Yoshiike, Y | 1 |
| Cusack, B; Davies, MP; Fauq, A; Johnson, JL; Rosenberry, TL | 1 |
| Clarke, K; DiCarlo, G; Gordon, MN; Henderson, D; Jackson, J; Morgan, D; Ugen, KE; Wilcock, DM | 1 |
| Fink, AL; Souillac, PO; Uversky, VN | 1 |
| Dobson, CM; Jass, J; Malisauskas, M; Morozova-Roche, LA; Noppe, W; Zamotin, V | 1 |
| Jones, S; Radford, SE; Serpell, LC; Smith, DP; Sunde, M | 1 |
| Du, HN; Hu, HY; Hu, J; Li, HT; Luo, XY; Tang, L; Zhou, JW | 1 |
| Fernandez, EJ; Good, TA; Tobler, SA; Wang, SS | 1 |
| Bouma, B; Brünjes, B; de Groot, PG; Gebbink, MF; Kranenburg, O; Kroon-Batenburg, LM; Posthuma, G; Voest, EE; Wu, YP | 1 |
| Dimitry, JM; Frazier, WA; McDonald, JF | 1 |
| Bellmann, C; Giasson, BI; Horiguchi, T; Ischiropoulos, H; Lee, VM; LightFoot, R; Richter-Landsberg, C; Trojanowski, JQ; Uryu, K | 1 |
| Fujita, T; Kimura, Y; Koitabashi, S | 1 |
| Cooke, PH; Farrell, HM; Hoagland, PD; Piotrowski, EG; Wickham, ED | 1 |
| CORDDRY, EG; GRAFFLIN, AL | 1 |
| HOBBS, JR; MORGAN, AD | 1 |
| SJAARDA, JR; WALFORD, RL | 1 |
| ROGERS, DR | 1 |
| BEERHALTER, H; BRUNS, G | 1 |
| Schmittschmitt, JP; Scholtz, JM | 1 |
| Hou, C; Jin, LW; Kung, HF; Kung, MP; Zhuang, ZP | 1 |
| Ahmad, A; Doniach, S; Fink, AL; Millett, IS; Uversky, VN | 1 |
| Dabir, D; Forman, MS; Goldbaum, O; Handschuh, M; Lee, VM; Oppermann, M; Richter-Landsberg, C; Trojanowski, JQ; Zhang, B | 1 |
| Jiang, Y; Li, H; Perrett, S; Zhou, JM; Zhu, L | 1 |
| Berry, Y; Carver, JA; Dobson, CM; Luisi, B; MacPhee, CE; Meehan, S | 1 |
| Brune, D; Childress, J; Esh, C; Farlow, M; Ghetti, B; Kalback, W; Kokjohn, TA; Kuo, YM; Lopez, J; Luehrs, DC; Murrell, J; Roher, AE; Vidal, R; Weiss, N | 1 |
| Calissano, P; Ciotti, MT; Galli, C; Krasnowska, E; Romano, A; Ruberti, F; Serafino, A | 1 |
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| Cremades, N; Dalla Serra, M; Dear, AJ; Dobson, CM; Horrocks, MH; Klenerman, D; Knowles, TP; Tosatto, L | 1 |
| Arnold, SE; Brettschneider, J; Cooper, F; Grossman, M; Irwin, DJ; Lee, EB; Lee, VM; McMillan, CT; Miller, BL; Olm, C; Seeley, WW; Trojanowski, JQ; Van Deerlin, VM | 1 |
| Baekelandt, V; Debyser, Z; Deleersnijder, A; Gerard, M; Macchi, F; Michiels, A; Munck, S; Pottel, H; Van den Haute, C | 1 |
| Bilkova, Z; Hromadkova, L; Jankovicova, B; Kupcik, R; Ripova, D; Rousar, T | 1 |
| Jiang, T; Li, Y; Liu, Q; Pan, K; Zhang, M; Zhou, X | 1 |
| Du, D; Elbassal, EA; Liu, H; Morris, C; Wojcikiewicz, EP | 1 |
| Fosso, MY; Garneau-Tsodikova, S; Head, E; LeVine, H; McCarty, K | 1 |
| Li, S; Teng, N; Wu, Y | 1 |
| Hannaberry, E; Raleigh, DP; Shea, JE; Watson, MD; Wong, AG; Wu, C | 1 |
| Barylyuk, K; Gath, J; Meier, BH; Nespovitaya, N; Riek, R; Seuring, C | 1 |
| Gong, H; Huang, K; Huang, L; Liu, J; Petersen, RB; Sun, Y; Yang, X; Zhang, X; Zheng, L | 1 |
| Beckwith, JS; Chen, SW; Cremades, N; Devine, MJ; Dobson, CM; Gandhi, S; Horrocks, MH; Iljina, M; Kjaergaard, M; Klenerman, D; Lee, SF; Magdalinou, NK; Tosatto, L; Wood, NW; Zetterberg, H | 1 |
| Chen, P; Davis, TP; Ding, F; Gurzov, EN; Hanssen, EG; Kakinen, A; Ke, PC; Litwak, SA; Pilkington, EH; Stanley, WJ; Wang, B | 1 |
| Das, S; Musgrave, IF; Pukala, T; Smid, SD; Stark, L | 1 |
| Jiang, XQ; Li, YY; Lu, LF; Shi, G; Zhang, M | 1 |
| Chen, H; Jin, S; Li, W; Liu, H; Ma, C; Wang, J | 1 |
| Choi, B; Crouzet, C; Lo, P; Vasilevko, V | 1 |
| Andersen, K; Foderà, V; Jäger, AK; Jorgensen, L; Lobbens, ES; Nyberg, NT; van de Weert, M | 1 |
| Hasegawa, K; Naiki, H; Okoshi, T; Ozawa, D; Yamaguchi, I | 1 |
| Segers-Nolten, I; Sidhu, A; Subramaniam, V | 1 |
| Hu, YH; Ren, WM; Tang, XC; Xu, MM; Zhang, HY | 1 |
| Mudliar, NH; Singh, PK | 1 |
| Ågren, H; Govindaraju, T; Kuang, G; Murugan, NA; Narayanaswamy, N; Rajasekhar, K | 1 |
| Fu, XN; Hou, HB; Liu, Y; Xu, X; Zhang, XJ; Zhang, YM | 1 |
| Chen, H; Guan, A; Li, Q; Liu, Y; Shi, Y; Sun, H; Tang, Y; Wang, L; Xiang, J; Xu, S; Yang, Q; Yu, L | 1 |
| Gu, M; Viles, JH | 1 |
| Ajmal, MR; Khan, MV; Khan, RH; Nusrat, S; Qadeer, A; Zakariya, SM; Zaman, M | 1 |
| Bhat, SA; Iram, A; Khan, RH; Naeem, A | 1 |
| Ekanayake, O; Ivancic, VA; Lazo, ND | 1 |
| Beyer, I; Haußmann, U; Jahn, O; Klafki, HW; Knölker, HJ; Rezaei-Ghaleh, N; Wiltfang, J; Zweckstetter, M | 1 |
| Bag, S; Chaudhury, S; DasGupta, S; Pramanik, D | 1 |
| Dai, Z; Wang, Z; Zhao, J | 1 |
| Belousov, MV; Bondarev, SA; Kuznetsova, IM; Sulatskaya, AI; Turoverov, KK; Zhouravleva, GA | 1 |
| Akaji, K; Asano, A; Doi, M; Katayama, M; Kawashima, H; Yoshida, R | 1 |
| Cinar, G; Guler, MO; Ide, S; Jeng, US; Orujalipoor, I; Su, CJ | 1 |
| Cheung, J; Martin, PK; Nix, AJ; Rosenberry, TL; Snyder, SA; Tan, RX; Wildman, SA | 1 |
| Boeri Erba, E; Breteau, N; Cooper, JB; Forsyth, VT; Haertlein, M; Mitchell, EP; Moulin, M; Yee, AW | 1 |
| Decossas-Mendoza, M; Krisa, S; Lambert, O; Mérillon, JM; Richard, T; Temsamani, H | 1 |
| Andersen, NH; Huggins, KN; Kapurniotu, A; Shu, I; Sivanesam, K; Tatarek-Nossol, M | 1 |
| Adachi, M; Akazawa-Ogawa, Y; Goto, Y; Hagihara, Y; Kardos, J; Noda, S; So, M | 1 |
| Ahmad, J; Ahmad, S; Arfat, MY; Arif, Z; Badar, A; Khan, MA; Neelofar, K; Zaman, A | 1 |
| Bednarikova, Z; Fedunova, D; Gazova, Z; Huy, PD; Li, MS; Mocanu, MM | 1 |
| Bouganov, OV; Kurhuzenkau, SA; Kuzmitsky, VA; Stsiapura, VI; Tikhomirov, SA | 1 |
| Breydo, L; Jäger, AK; Jorgensen, L; Lobbens, ES; Skamris, T; Uversky, V; van de Weert, M; Vestergaard, B | 1 |
| Alberi, L; Alina Raio, N; Brai, E | 1 |
| Carvalho, T; Freire, CS; Martins, MA; Pinto, RJ; Silvestre, AJ | 1 |
| Abbate, S; Babenko, V; Castiglioni, E; Dzwolak, W; Longhi, G; Pecul, M; Rybicka, A | 1 |
| Ajmal, MR; Alam, P; Badr, G; Chaturvedi, SK; Jamal, MS; Khan, RH; Mahmoud, MH; Nusrat, S; Siddiqi, MK; Zaidi, N; Zaman, M | 1 |
| DeGrado, WF; Elkins, MR; Hong, M; Jo, H; Lemmin, T; Nick, M; Prusiner, SB; Stöhr, J; Wang, T | 1 |
| Hemmateenejad, B; Khoshaman, K; Masoudi, R; Yousefi, R; Zm, SZ | 1 |
| Dong, H; Gong, X; He, C; Hussain, M; Shen, L; Shezad, K; Xie, X; Zhang, K; Zhu, J | 1 |
| Ebrahim-Habibi, A; Es-Haghi, A; Nemat-Gorgani, M; Sabbaghian, M | 1 |
| Alberti, S; Boke, E; Coughlin, M; Drechsel, D; Gygi, SP; Hyman, AA; Lemaitre, R; Mitchison, TJ; Ruer, M; Wühr, M | 1 |
| Benesch, J; Buell, AK; De Genst, E; Dobson, CM; Knowles, TP; Müller, T; Zhang, Y | 1 |
| Carver, JA; Dalpadado, RC; Hall, D; Maat, H | 1 |
| Du, YC; Kong, DM; Zhu, LN | 1 |
| Raleigh, DP; Wong, AG | 1 |
| Barbour, RM; Dolan, PJ; Kinney, GG; Li, L; Nijjar, T; Renz, M; Salmans, JR; Schenk, D; Shughrue, PJ; Tam, SJ; Tapia, JR; Torres, R; Zago, W | 1 |
| Fan, HX; Feng, XL; Gao, H; He, RR; Kurihara, H; So, KF; Xiao, J; Yao, XS; Yu, Y; Zhou, ZQ | 1 |
| Wang, H; Wei, B; Xie, D; Yang, H; Zhang, H; Zhang, J; Zou, M | 1 |
| Ahmed, A; Bano, B; Shamsi, A | 1 |
| Alam, P; Chaturvedi, SK; Khan, RH; Siddiqi, MK | 1 |
| André, I; Faller, P; Gras, E; Hoarau, M; Hureau, C; Irague, R; Malbert, Y; Remaud-Siméon, M | 1 |
| Chemuru, S; Kar, K; Kodali, R; Misra, P; Wetzel, R | 1 |
| Li, Y; Lou, X; Wu, X; Xu, Q; Xu, S; Yang, X; Zhao, Y | 1 |
| Liu, H; Ma, C; Wang, J; Wang, K; Wu, K; Xia, K | 1 |
| He, R; Ji, M; Li, S; Lin, D; Wang, J; Wei, G; Xu, Y; Yang, X | 1 |
| Cutress, RI; Greenhough, J; Oreffo, ROC; Papadakis, ES; Tare, RS; Townsend, PA | 1 |
| Arab, SS; Ashrafi-Kooshk, MR; Jangholi, A; Khodarahmi, R; Kurganov, BI; Mahdiuni, H; Mokhtari, F; Moosavi-Movahedi, AA; Poorebrahim, M; Riazi, G | 1 |
| Mudliar, NH; Pettiwala, AM; Sadhu, B; Singh, PK | 1 |
| Adler, J; Huster, D; Krueger, M; Scheidt, HA | 1 |
| Andreasen, N; Andreasson, U; Blennow, K; Borén, J; Cukalevski, R; Linse, S; Molinuevo, JL; Padayachee, ER; Portelius, E; Zetterberg, H | 1 |
| da Silva, DC; Erthal, LC; Fontes, GN; Lima, LM | 1 |
| Li, T; Liu, S; Peng, P; Wang, H | 1 |
| Mora, AK; Nath, S; Patro, BS; Singh, PK | 1 |
| Alamelu, A; Chattopadhyay, S; Mora, AK; Murudkar, S; Nath, S; Singh, PK | 1 |
| Fuchigami, T; Haratake, M; Masuda, N; Nakayama, M; Takiguchi, T; Yoshida, S | 1 |
| Abdelhameed, AS; Ishtikhar, M; Khan, MV; Khan, RH; Rabbani, G; Zaman, M | 1 |
| Liu, H; Ma, C; Wang, J; Wu, K; Zhong, L | 1 |
| Christiansen, G; Dueholm, MS; Geifman-Shochat, S; Kjelleberg, S; Meyer, RL; Nielsen, PH; Otzen, DE; Seviour, T; Stenvang, M; Søndergaard, MT; Vad, BS; Zeng, G | 1 |
| Ajmal, MR; Islam, S; Khan, RH; Nusrat, S; Santra, MK; Siddiqi, MK; Zaidi, N; Zaman, M | 1 |
| Hiramatsu, H; Osaki, D | 1 |
| Collins, SJ; Haigh, CL | 1 |
| Chen, RP; Chou, WL; How, SC; Hsin, A; Hsueh, SS; Lin, MS; Tseng, CP; Wang, SS; Yang, SM | 1 |
| Goo, NI; Kim, DE; Lee, IJ | 1 |
| Guo, R; Li, B; Li, W; Niu, B; Qiao, M; Wang, H; Xu, H | 1 |
| Kozar, T; Musatov, A; Siposova, K | 1 |
| Chorell, E; Eriksson, J; Jamroskovic, J; Livendahl, M; Sabouri, N | 1 |
| Dasgupta, M; Kishore, N | 1 |
| Chi, H; Keiderling, TA | 1 |
| Diaz-Espinoza, R; Monasterio, O; Nova, E | 1 |
| Aubin, Y; Sauvé, S | 1 |
| Awasthi, AA; Mudliar, NH; Pettiwala, AM; Singh, PK | 1 |
| Hinckley, SH; Kuret, J; Lin, L; Nanavaty, N | 1 |
| Kitauchi, K; Sakono, M | 1 |
| Arif, H; Bano, B; Bhat, SA; Faraz, M; Siddiqui, AA; Sohail, A | 1 |
| Baldock, S; Hughes, E; Hussain, R; Madine, J; Middleton, DA; Siligardi, G; Townsend, D | 1 |
| Li, L; Liu, G; Wang, L; Wen, Y; Xu, L | 1 |
| Schlein, M | 1 |
| Baumann, A; Horvath, I; Jorge-Finnigan, A; Jung-Kc, K; Martinez, A; Morozova-Roche, LA; Sauter, A | 1 |
| Bickle, L; Hopwood, JJ; Karageorgos, L | 1 |
| Bajaj, M; Brar, SK; Katare, OP; Mithu, VS; Narang, N; Sharma, RK; Singh, P; Wangoo, N | 1 |
| Ashe, KH; Borchelt, DR; Forster, CL; Hemmy, LS; Huang, ES; Kuskowski, MA; Liu, P; McNellis, BM; Rao, ER; Reichl, JH; Vassar, R; Zahs, KR | 1 |
| Chen, S; Li, Y; Lin, B; Nie, Z; Wang, H; Wang, Q; Yao, S; Zhao, K | 1 |
| Hasegawa, M; Higuchi, M; Hisanaga, SI; Imura, S; Masuda-Suzukake, M; Ono, M; Shimozawa, A; Takahara, D; Tarutani, A; Yanai, K | 1 |
| Jin, Y; Li, B; Liu, M; Liu, Q; Zhao, H | 1 |
| Gbajumo, O; Marshall, KE; Serpell, LC; Vadukul, DM | 1 |
| Angeli, S; Bhaumik, D; Chamoli, M; Chang, C; Chao, EA; Chen, E; Chen, MK; Coleman-Hulbert, AL; Crist, AB; Driscoll, M; Dumas, KJ; Edgar, D; Foulger, AC; Garrett, T; Guo, M; Guo, S; Harinath, G; Harke, J; Hope, J; Ibanez-Ventoso, C; Johnson, E; Kamat, S; Kish, JL; Lithgow, GJ; Lucanic, M; Onken, B; Patel, S; Phillips, PC; Plummer, WT; Presley, MP; Royal, MA; Sedore, CA; Willis, JH; Xue, J | 1 |
| Alam, MT; Ali, A; Furkan, M; Khan, K; Naeem, A; Rizvi, A | 1 |
| Carlisle, RE; Dickhout, JG; Upagupta, C | 1 |
| Claessens, MM; Raussens, V; Segers-Nolten, I; Sidhu, A; Subramaniam, V | 1 |
| Bai, D; Chen, J; Ge, J; Ji, D; Li, J; Li, Z; Wang, H; Zhang, L | 1 |
| Girych, M; Gorbenko, G; Kinnunen, P; Maliyov, I; Mizuguchi, C; Saito, H; Trusova, V | 1 |
| Blancas-Mejia, LM; Buchner, J; Gade Malmos, K; Naiki, H; Otzen, D; Ramirez-Alvarado, M; Weber, B | 1 |
| Esbjörner, EK; Lindberg, DJ; Sundin, E; Wenger, A; Wesén, E; Westerlund, F | 1 |
| Chakraborty, M; Dasgupta, S; Goley, S; Sen, S | 1 |
| Dammers, C; Gremer, L; Lecher, J; Reiss, K; Schwarten, M; Stoldt, M; Willbold, D; Ziehm, T | 1 |
| Kiran Kumar, E; Prakash Prabhu, N; Prasad, DK | 1 |
| Booth, PJ; Chirgadze, DY; Dobson, CM; Harris, NJ; Kumita, JR; Stroobants, K; Vendruscolo, M | 1 |
| Jia, B; Ma, G; Ma, Y; Qin, Z; Sun, Y; Wang, D | 1 |
| Duan, H; Fang, X; Liu, C; Peng, J; Wang, C; Xie, H; Yang, Y; Zou, Y | 1 |
| Das, S; Marsh, DT; Ridell, J; Smid, SD | 1 |
| Bourgault, S; Quittot, N; Sebastiao, M | 1 |
| Aigbirhio, FI; Buell, AK; Fisher, E; Janik, M; Richardson, R; Tóth, G; Zhao, Y | 1 |
| Bourgault, S; Nguyen, PT; Sebastiao, M; Zottig, X | 1 |
| Chen, Y; Jiang, F; Lei, H; Li, JD; Ma, YT; Tan, J; Zhang, J; Zhang, Y | 1 |
| Bednarikova, Z; Gazova, Z; Huy, PDQ; Li, MS; Linh, HQ; Phuc, LH; Thai, NQ | 1 |
| Pettiwala, AM; Singh, PK | 1 |
| Ackermann, M; Denver, P; Kelly, P; Konerding, MA; Mitchell, CA; Satchell, SC | 1 |
| Gospodarczyk, W; Kozak, M | 1 |
| Kumar, H; Kumari, P; Singh, J; Udgaonkar, JB | 1 |
| Hart, JL; Mawhinney, MT; Taheri, ML; Urbanc, B; Williams, TL | 1 |
| Aguan, K; Bhattacharjee, A; Gurung, AB; Islam, MM; Mitra, S; Rohman, MA | 1 |
| Abdelhameed, AS; Khan, RH; Masroor, A; Neelofar, K; Nusrat, S; Siddqi, MK; Zaidi, N; Zaman, M | 1 |
| Ahmad, I; Han, Q; Li, C; Liang, X; Mozhi, A; Wang, C; Yang, L; Yang, R | 1 |
| Contreras-García, J; Guallar, V; Pantaleone, S; Peccati, F; Riffet, V; Sodupe, M; Solans-Monfort, X | 1 |
| Anson, KJ; Campbell, KJ; Caughey, B; Groveman, BR; Hughson, AG; Kraus, A; Manca, M; Orrù, CD; Raymond, GJ; Raymond, LD | 1 |
| Hu, B; Huang, J; Li, J; Liang, C; Liu, X; Wu, W; Ye, Z; Zeng, L; Zhang, X | 1 |
| Abel, BA; Das, PK; Dean, DN; Fogel, AL; Kharlampieva, E; Liu, F; McCormick, CL; Morgan, SE; Rangachari, V | 1 |
| Azami-Movahed, M; Ebrahim-Habibi, A; Ghasemi, A; Meratan, AA; Nemat-Gorgani, M | 1 |
| Abskharon, R; Castilla, J; Dang, J; Elfarash, A; Fujioka, H; Hassan, S; Mulaj, M; Shen, P; Steyaert, J; Surewicz, WK; Wang, F; Wang, Z; Wohlkonig, A; Zou, LS; Zou, WQ | 1 |
| Li, T; Liu, S; Peng, P; Shi, L; Wang, H | 1 |
| Basu, A; Bhattacharya, SC; Kumar, GS | 1 |
| Davis, TP; Ding, F; Kakinen, A; Ke, PC; Nowell, CJ; Pilkington, EH; Sun, Y; Wang, B; Wang, M; Xing, Y | 1 |
| Iwakawa, N; Kawata, Y; Morimoto, D; Shirakawa, M; Sugase, K; Walinda, E | 1 |
| Arakida, J; Kikuchi, JI; Ramadugu, SK; Ramamoorthy, A; Ravula, T; Sahoo, B; Yasuhara, K | 1 |
| Bag, S; Biswas, P; Chaudhury, S; Das, AK; Dasgupta, S; Dutta, A | 1 |
| Konar, S; Pathak, A; Sen, S | 1 |
| Fadeev, VV; Litskevich, AY; Maskevich, AA; Rovnyagina, NR; Shirshin, EA; Sluchanko, NN; Tikhonova, TN | 1 |
| Chung, YJ; Lee, BI; Park, CB; Son, G | 1 |
| Chen, T; Li, W; Tan, S; Zhu, Y | 1 |
| Bowers, MT; Folmert, K; Hoffmann, W; Huang, X; Koksch, B; Moschner, J; Pagel, K; von Berlepsch, H; von Helden, G | 1 |
| Du, YC; Kong, DM; Li, XY; Zhu, YJ | 1 |
| Guo, Z; Hao, Q; Jiang, W; Liu, Y; Rustam, B; Zhu, J | 1 |
| Taniguchi, A | 1 |
| Chen, H; Guan, A; Li, Q; Liu, M; Shi, Y; Sun, H; Tang, Y; Wang, L; Xu, S; Zhang, S | 1 |
| Ishii, Y; McElheny, D; Xiao, Y; Yoo, BK | 1 |
| Azarpira, N; Firoozabadi, V; Nazari-Vanani, R; Sattarahmady, N | 1 |
| Han, L; Li, NB; Luo, HQ; Xu, HM; Zhang, XF | 1 |
| Cui, M; Fu, H | 1 |
| Hassani, L; Mahmudian, A; Moeeni, M; Mohammadi, F | 1 |
| Bogun, M; Chaberska, A; Draczynski, Z; Fraczyk, J; Kaminska, M; Kaminski, ZJ; Kolesinska, B; Lipinski, W; Menaszek, E; Rozniakowski, K; Stodolak-Zych, E; Wasko, J | 1 |
| Deng, Z; Fang, N; Ma, C; Tang, Z; Wang, K; Wu, K; Zhu, X | 1 |
| Bruckert, F; Chouchane, K; Pignot-Paintrand, I; Weidenhaupt, M | 1 |
| Ben Jannet, H; Bucciantini, M; Dhouafli, Z; Gadhoumi, H; Guillard, J; Hayouni, EA; Ksouri, R; Leri, M; Mahjoub, B; Saidani Tounsi, M; Soto, C; Stefani, M | 1 |
| Abeyawardhane, DL; Crozier, MK; Fernández, RD; Forney, AK; Heitger, DR; Lucas, HR; Murgas, CJ | 1 |
| Chen, Y; Hua, Y; Qiu, F; Tang, C; Wang, Y; Zhang, W; Zhang, Y | 1 |
| Bellomo, G; Bologna, S; Fragai, M; Gonnelli, L; Lelli, M; Luchinat, C; Ravera, E | 1 |
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19 review(s) available for thioflavin t and thiazoles
| Article | Year |
|---|---|
[Therapeutics for prion diseases].
Topics: Amyloid; Animals; Benzothiazoles; Clinical Trials as Topic; Drug Design; Humans; Pentosan Sulfuric Polyester; Prion Diseases; Prions; Protein Binding; Quinacrine; Thiazoles | 2003 |
Development of novel amyloid imaging agents based upon thioflavin S.
Topics: Amyloid; Benzothiazoles; Diagnostic Imaging; Fluorescent Dyes; Humans; Technology, Pharmaceutical; Thiazoles | 2005 |
[Molecular imaging of beta-amyloid plaques in the brain].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Benzothiazoles; Brain; Congo Red; Humans; Mice; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles; Tomography, Emission-Computed, Single-Photon | 2007 |
Development of tau aggregation inhibitors for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Databases, Factual; Humans; tau Proteins; Tauopathies; Thiazoles | 2009 |
Formation mechanism of insulin fibrils and structural aspects of the insulin fibrillation process.
Topics: Amino Acid Sequence; Amyloid; Animals; Benzothiazoles; Biochemistry; Cell Nucleus; Congo Red; Humans; Insulin; Kinetics; Microscopy, Fluorescence; Models, Biological; Molecular Sequence Data; Peptides; Protein Conformation; Thiazoles | 2009 |
Molecular mechanism of Thioflavin-T binding to amyloid fibrils.
Topics: Amyloid; Animals; Benzothiazoles; Binding Sites; Fluorescent Dyes; Humans; Models, Chemical; Molecular Conformation; Molecular Probes; Protein Binding; Protein Conformation; Spectrophotometry; Thiazoles; Time Factors | 2010 |
Studying the effects of chaperones on amyloid fibril formation.
Topics: Amyloid; Benzothiazoles; Chromatography, Gel; Filtration; Fluorometry; Humans; Light; Micropore Filters; Molecular Chaperones; Quartz Crystal Microbalance Techniques; Scattering, Radiation; Surface Plasmon Resonance; Thiazoles | 2011 |
Insight into amyloid structure using chemical probes.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Animals; Benzothiazoles; Coloring Agents; Congo Red; Humans; Molecular Sequence Data; Protein Conformation; Thiazoles | 2011 |
Nanotechnologies for Alzheimer's disease: diagnosis, therapy, and safety issues.
Topics: Acridines; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Biocompatible Materials; Biomarkers; Brain; Chromones; Drug Delivery Systems; Ferric Compounds; Gold; Humans; Magnetite Nanoparticles; Nanoparticles; Thiazoles | 2011 |
Molecular imaging of amyloidosis: will the heart be the next target after the brain?
Topics: 3-Iodobenzylguanidine; Amyloidosis; Benzothiazoles; Early Diagnosis; Female; Fluorescent Dyes; Heart Diseases; Humans; Male; Molecular Imaging; Positron-Emission Tomography; Radiopharmaceuticals; Technetium Tc 99m Medronate; Technetium Tc 99m Pyrophosphate; Thiazoles | 2012 |
Molecular rotors: what lies behind the high sensitivity of the thioflavin-T fluorescent marker.
Topics: Benzothiazoles; Fluorescent Dyes; Photochemical Processes; Quantum Theory; Thiazoles | 2012 |
Dye-binding assays for evaluation of the effects of small molecule inhibitors on amyloid (aβ) self-assembly.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Coloring Agents; Congo Red; Drug Discovery; False Positive Reactions; Fluorescent Dyes; Humans; Reproducibility of Results; Thiazoles | 2012 |
Agitation of amyloid proteins to speed aggregation measured by ThT fluorescence: a call for standardization.
Topics: Amyloid; Benzothiazoles; Fluorescence; Humans; Protein Aggregates; Protein Denaturation; Thiazoles | 2015 |
Molecular pathogenesis of human amyloidosis: Lessons from β2 -microglobulin-related amyloidosis.
Topics: Amyloid; Amyloidosis; Benzothiazoles; beta 2-Microglobulin; Fluorometry; Humans; Models, Molecular; Polymerization; Thiazoles | 2016 |
Advances in development of fluorescent probes for detecting amyloid-β aggregates.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Boron Compounds; Curcumin; Fluorescent Dyes; Humans; Optical Imaging; Stilbenes; Thiazoles; Thiophenes | 2016 |
Insulin Formulation Characterization-the Thioflavin T Assays.
Topics: Amyloid; Benzothiazoles; Biological Assay; Diabetes Mellitus, Type 2; Drug Design; Fluorescent Dyes; Humans; Hypoglycemic Agents; Insulin; Thiazoles | 2017 |
ThT 101: a primer on the use of thioflavin T to investigate amyloid formation.
Topics: Amyloid; Animals; Benzothiazoles; Humans; Photochemistry; Thiazoles | 2017 |
[Amyloid-selective Photooxygenation toward Treatment for Amyloid Diseases].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Catalysis; Dinitrocresols; Drug Discovery; Humans; Oxidation-Reduction; Photochemical Processes; Protein Aggregation, Pathological; Protein Binding; Riboflavin; Thiazoles | 2018 |
Fluorescent Imaging of Amyloid-β Deposits in Brain: An Overview of Probe Development and a Highlight of the Applications for In Vivo Imaging.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Brain; Congo Red; Curcumin; Fluorescent Dyes; Humans; Microscopy, Fluorescence, Multiphoton; Positron Emission Tomography Computed Tomography; Thiazoles | 2018 |
2 trial(s) available for thioflavin t and thiazoles
| Article | Year |
|---|---|
Whole-body biodistribution and brain PET imaging with [18F]AV-45, a novel amyloid imaging agent--a pilot study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Aniline Compounds; Benzothiazoles; Brain; Case-Control Studies; Ethylene Glycols; Female; Fluorescent Dyes; Fluorine Radioisotopes; Humans; Male; Middle Aged; Pilot Projects; Positron-Emission Tomography; Radiometry; Thiazoles | 2010 |
Pharmacodynamics of cholinesterase inhibitors suggests add-on therapy with a low-dose carbamylating inhibitor in patients on long-term treatment with rapidly reversible inhibitors.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Blotting, Western; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Drug Therapy, Combination; Fluorescence; Follow-Up Studies; Humans; Indans; Physostigmine; Piperidines; Thiazoles; Time Factors | 2014 |
1287 other study(ies) available for thioflavin t and thiazoles
| Article | Year |
|---|---|
An improved thioflavine S method for staining neurofibrillary tangles and senile plaques in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Fluorescent Dyes; Hippocampus; Humans; Neurofibrillary Tangles; Staining and Labeling; Thiazoles | 1992 |
A comparative study of histological and immunohistochemical methods for neurofibrillary tangles and senile plaques in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Humans; Immunohistochemistry; Neurofibrillary Tangles; Staining and Labeling; Thiazoles | 1992 |
Racemized D-aspartate in Alzheimer neurofibrillary tangles.
Topics: Alzheimer Disease; Aspartic Acid; Benzothiazoles; Chromatography, Gas; Fluorescent Dyes; Humans; Nerve Tissue Proteins; Neurofibrillary Tangles; Stereoisomerism; Thiazoles | 1992 |
Laminar distribution of neuron degeneration in posterior cingulate cortex in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Cerebral Cortex; Female; Humans; Male; Middle Aged; Nerve Degeneration; Neurons; Staining and Labeling; Thiazoles | 1990 |
Senile dementia of the Alzheimer type: is there a correlation between entorhinal cortex and dentate gyrus lesions?
Topics: Acetylcholinesterase; Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Cerebral Cortex; Dementia, Vascular; Female; Hippocampus; Humans; Immunohistochemistry; Middle Aged; Neurofibrillary Tangles; tau Proteins; Thiazoles | 1991 |
Identification of immunoglobulin light chains in canine extramedullary plasmacytomas by thioflavine T and immunohistochemistry.
Topics: Animals; Benzothiazoles; Breeding; Dog Diseases; Dogs; Female; Fluorescent Dyes; Immunoglobulin Light Chains; Immunohistochemistry; Male; Plasmacytoma; Skin Neoplasms; Thiazoles | 1991 |
Evidence for axonal loss in regions occupied by senile plaques in Alzheimer cortex.
Topics: Alzheimer Disease; Amyloid; Axons; Benzothiazoles; Cytoskeleton; Fluorescent Antibody Technique; Fluorescent Dyes; Frontal Lobe; Humans; Image Processing, Computer-Assisted; Nerve Tissue Proteins; Neurofilament Proteins; Thiazoles | 1991 |
[Neuropathologic study of 50 cases of senile dementia].
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloidosis; Benzothiazoles; Brain; Cerebrovascular Disorders; Dementia; Dementia, Vascular; Female; Fluorescent Dyes; Humans; Male; Middle Aged; Prospective Studies; Thiazoles | 1990 |
Fluorometric examination of tissue amyloid fibrils in murine senile amyloidosis: use of the fluorescent indicator, thioflavine T.
Topics: Aging; Amyloid; Amyloidosis; Animals; Benzothiazoles; Fluorescent Dyes; Liver; Mice; Mice, Inbred Strains; Spectrometry, Fluorescence; Spleen; Thiazoles | 1990 |
Changes in capillary perfusion induced by different patterns of activity in rat skeletal muscle.
Topics: Animals; Benzothiazoles; Capillaries; Fluorescent Dyes; Male; Muscle Contraction; Muscles; Myofibrils; Rats; Rats, Inbred Strains; Regional Blood Flow; Thiazoles | 1990 |
Reproducibility of morphometric measurements of amyloid after various staining methods.
Topics: Amyloid; Amyloidosis; Azo Compounds; Benzothiazoles; Congo Red; Gentian Violet; Humans; Myocardium; Staining and Labeling; Thiazoles | 1985 |
Thiazole orange: a new dye for reticulocyte analysis.
Topics: Benzothiazoles; Cell Count; DNA; Flow Cytometry; Fluorescent Dyes; Humans; Quinolines; Reticulocytes; RNA; Thiazoles | 1986 |
Hypothalamic pathology in Alzheimer's disease.
Topics: Acetylcholinesterase; Aged; Alzheimer Disease; Benzothiazoles; Cerebral Cortex; Female; Hippocampus; Humans; Hypothalamus; Male; Middle Aged; Neurofibrils; Staining and Labeling; Thiazoles | 1987 |
Observation of morphological relationships between angiopathic blood vessels and degenerative neurites in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Benzothiazoles; Brain; Cerebrovascular Disorders; Congo Red; Female; Humans; Neurofibrils; Staining and Labeling; Thiazoles | 1987 |
Transformation of degenerating neurofibrils into amyloid substance in Alzheimer's disease: histochemical and immunohistochemical studies.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Benzothiazoles; Brain; Histocytochemistry; Humans; Immunohistochemistry; Nerve Degeneration; Neurofibrils; Staining and Labeling; Thiazoles | 1987 |
Amyloid P component binds to keratin bodies in human skin and to isolated keratin filament aggregates in vitro.
Topics: Benzothiazoles; Calcium; Cells, Cultured; Congo Red; Cytoskeleton; Electrophoresis, Polyacrylamide Gel; Humans; Intermediate Filaments; Keratins; Serum Amyloid P-Component; Skin; Staining and Labeling; Thiazoles; Trypsin | 1988 |
Does amyloid precede paired helical filaments in the senile plaque? A study of 15 cases with graded intellectual status in aging and Alzheimer disease.
Topics: Aged; Aging; Alzheimer Disease; Amyloid; Benzothiazoles; Brain; Female; Humans; Immunohistochemistry; Intermediate Filaments; Staining and Labeling; Thiazoles | 1988 |
[Alzheimer's disease: immunohistochemical characterization of cerebral amyloid deposits].
Topics: Alzheimer Disease; Amyloid; Antibodies; Benzothiazoles; Cerebral Cortex; Fluorescent Dyes; Glycoside Hydrolases; Humans; Immunohistochemistry; Periodic Acid; Thiazoles | 1989 |
Prevalence and ultrastructural characteristics of bovine mammary corpora amylacea during the lactation cycle.
Topics: Amyloid; Animals; Benzothiazoles; Cattle; Female; Inclusion Bodies; Lactation; Mammary Glands, Animal; Microscopy, Electron; Pregnancy; Staining and Labeling; Thiazoles; Time Factors | 1985 |
Monoclonal antibody to embryonic CNS antigen A2B5 provides evidence for the involvement of membrane components at sites of Alzheimer degeneration and detects sulfatides as well as gangliosides.
Topics: Alzheimer Disease; Animals; Antibodies, Monoclonal; Antigens, Surface; Benzothiazoles; Brain Chemistry; Cell Membrane; Chick Embryo; Fluorescent Antibody Technique; Frontal Lobe; Gangliosides; Hippocampus; Histocytochemistry; Humans; Immunoenzyme Techniques; Mice; Neurofibrils; Retina; Sulfoglycosphingolipids; Thiazoles | 1989 |
Evidence that epinephrine acutely redistributes blood flow to experimental intrahepatic tumors.
Topics: Animals; Benzothiazoles; Carcinoma 256, Walker; Epinephrine; Female; Fluorescent Dyes; Liver Neoplasms, Experimental; Microcirculation; Rats; Rats, Inbred Strains; Regional Blood Flow; Thiazoles | 1989 |
[Quantitative analysis of the distribution of acetylcholinesterase-positive senile plaques in the hippocampal formation in patients with senile dementia of Alzheimer type].
Topics: Acetylcholinesterase; Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Hippocampus; Humans; Thiazoles | 1988 |
Cortical angiopathy in Alzheimer's disease: the formation of dystrophic perivascular neurites is related to the exudation of amyloid fibrils from the pathological vessels.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Arterioles; Benzothiazoles; Capillaries; Cerebral Cortex; Fluorescent Dyes; Humans; Immunohistochemistry; Nerve Fibers; Thiazoles | 1988 |
Fluorescence-activated flow cytometry in the hematology clinical laboratory.
Topics: Adult; Animals; Benzothiazoles; Erythrocyte Count; Female; Flow Cytometry; Fluorescent Dyes; Humans; Infant, Newborn; Male; Rabbits; Reference Values; Reticulocytes; Thiazoles | 1988 |
Flow cytometric purification of Alzheimer's disease amyloid plaque core protein using thioflavin T.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Brain Chemistry; Flow Cytometry; Fluorescent Dyes; Humans; Lipofuscin; Microscopy, Fluorescence; Spectrometry, Fluorescence; Thiazoles | 1987 |
Flow cytometric reticulocyte counting with thioflavin T in a clinical hematology laboratory.
Topics: Benzothiazoles; Clinical Laboratory Techniques; Costs and Cost Analysis; Flow Cytometry; Fluorescent Dyes; Humans; Reticulocytes; Thiazoles | 1987 |
A study of interaction of thioflavine T with DNA: evidence for intercalation.
Topics: Animals; Benzothiazoles; Chickens; DNA; Fluorescent Dyes; Intercalating Agents; Mast Cells; Spectrometry, Fluorescence; Thiazoles | 1987 |
Comparison of methods for analysis of CSF proteins in patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Cerebrospinal Fluid Proteins; Electrophoresis; Humans; Microscopy, Electron; Middle Aged; Silver; Thiazoles | 1987 |
Growth patterns and histochemical characterization of bovine mammary corpora amylacea.
Topics: Aminosalicylic Acid; Animals; Anthraquinones; Azo Compounds; Benzothiazoles; Carmine; Cattle; Cell Division; Coloring Agents; Congo Red; Female; Lactation; Mammary Glands, Animal; Pregnancy; Silver Nitrate; Thiazoles; Tolonium Chloride | 1986 |
Coronary venous perfusion of the ischemic myocardium during acute coronary artery occlusion in isolated rat hearts.
Topics: Acute Disease; Animals; Arterial Occlusive Diseases; Benzothiazoles; Coronary Disease; Coronary Vessels; Fluorescein; Fluoresceins; In Vitro Techniques; Male; Myocardium; NAD; Perfusion; Photography; Rats; Rats, Inbred Strains; Thiazoles | 1985 |
Neuronal pathology in the nucleus basalis and associated cell groups in senile dementia of the Alzheimer's type: possible role in cell loss.
Topics: Acetylcholinesterase; Aged; Alzheimer Disease; Basal Ganglia; Benzothiazoles; Brain; Female; Humans; Male; Neurofibrils; Phenothiazines; Substantia Innominata; Thiazoles | 1985 |
[Inclusions fixing thioflavin T in plasmacytes of IgG lambda myeloma with amylosis].
Topics: Aged; Amyloidosis; Benzothiazoles; Bone Marrow; Female; Humans; Immunoglobulin lambda-Chains; Immunoglobulin Light Chains; Inclusion Bodies; Male; Middle Aged; Multiple Myeloma; Plasma Cells; Staining and Labeling; Thiazoles | 1982 |
[Methods for cytologic and histologic determination of phospholipids in lung tissue].
Topics: Benzothiazoles; Chlorides; Fluorescent Dyes; Histological Techniques; Humans; Lung; Microscopy, Fluorescence; Phosphines; Phospholipids; Pulmonary Surfactants; Staining and Labeling; Thiazoles | 1983 |
A rapid, vital staining procedure for flow cytometric analysis of human reticulocytes.
Topics: Benzothiazoles; Erythrocyte Count; Flow Cytometry; Fluorescent Dyes; Humans; Reticulocytes; Staining and Labeling; Thiazoles | 1983 |
A human ganglioglioma containing paired helical filaments.
Topics: Adolescent; Adult; Benzothiazoles; Birefringence; Cells, Cultured; Congo Red; Female; Humans; Male; Microscopy, Electron; Microscopy, Fluorescence; Nervous System Neoplasms; Neuroblastoma; Neurofibrils; Neurons; Thiazoles | 1984 |
[Experimental model for determination of an "in vivo" area at risk accounting for the quantity and distribution of collateral flow (author's transl)].
Topics: Animals; Arrhythmias, Cardiac; Autoradiography; Benzothiazoles; Collateral Circulation; Coronary Circulation; Disease Models, Animal; Dogs; Fluorescent Dyes; Microspheres; Myocardial Infarction; Risk; Serum Albumin; Thiazoles | 1982 |
Thioflavin T fluorescence in membranoproliferative glomerulonephritis.
Topics: Benzothiazoles; Biopsy; Fluorescent Dyes; Glomerulonephritis; Humans; Kidney Glomerulus; Microscopy, Electron; Microscopy, Fluorescence; Thiazoles | 1982 |
Aluminum promotes the aggregation of Alzheimer's amyloid beta-protein in vitro.
Topics: Aluminum Chloride; Aluminum Compounds; Amyloid beta-Peptides; Benzothiazoles; Chemical Precipitation; Chlorides; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Fluorescent Dyes; Immunoblotting; Peptide Fragments; Staining and Labeling; Thiazoles | 1994 |
Dendritic reorganisation in the basal forebrain under degenerative conditions and its defects in Alzheimer's disease. II. Ageing, Korsakoff's disease, Parkinson's disease, and Alzheimer's disease.
Topics: Adult; Aged; Aging; Alcohol Amnestic Disorder; Alzheimer Disease; Benzothiazoles; Cell Count; Dendrites; Female; Fluorescent Dyes; Histocytochemistry; Humans; Male; Middle Aged; Nerve Degeneration; Neuronal Plasticity; Parkinson Disease; Prosencephalon; Staining and Labeling; Thiazoles | 1995 |
Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans.
Topics: Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Antibodies, Monoclonal; Base Sequence; Benzothiazoles; Caenorhabditis; Chimera; DNA Primers; Epitopes; Fluorescent Dyes; Genotype; Humans; Immunohistochemistry; Male; Molecular Sequence Data; Prealbumin; Recombinant Fusion Proteins; Restriction Mapping; Thiazoles | 1995 |
Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments.
Topics: Alzheimer Disease; Benzothiazoles; Brain; Cysteine; Fluorescent Dyes; Humans; Neurofibrillary Tangles; Oxidation-Reduction; Phosphorylation; Protein Conformation; Sulfhydryl Reagents; tau Proteins; Thiazoles | 1995 |
Alterations in neurofilament protein immunoreactivity in human hippocampal neurons related to normal aging and Alzheimer's disease.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Benzothiazoles; Female; Hippocampus; Humans; Immunoblotting; Immunohistochemistry; Male; Middle Aged; Neurofilament Proteins; Neurons; Reference Values; Thiazoles | 1994 |
Enhanced aggregation and beta structure of amyloid beta peptide after coincubation with C1q.
Topics: Amyloid beta-Peptides; Analysis of Variance; Benzothiazoles; Complement C1q; Congo Red; Electrophoresis, Polyacrylamide Gel; Fluorescent Dyes; Solubility; Spectrometry, Fluorescence; Spectrophotometry; Thiazoles | 1994 |
Pancreatic expression and secretion of human islet amyloid polypeptide in a transgenic mouse.
Topics: Amyloid; Animals; Benzothiazoles; Blood Glucose; Blotting, Northern; Female; Fluorescent Dyes; Gene Expression; Humans; Insulin; Islet Amyloid Polypeptide; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Proinsulin; RNA, Messenger; Thiazoles | 1994 |
Neurofibrillary tangles in the cerebral cortex of sheep.
Topics: Animals; Antibodies, Monoclonal; Antigens; Benzothiazoles; Cerebral Cortex; Immunohistochemistry; Nerve Degeneration; Nerve Tissue Proteins; Neurofibrillary Tangles; Neurofibrils; Sheep; Silver Staining; tau Proteins; Thiazoles | 1994 |
Two types of dystrophic neurites in senile plaques of Alzheimer disease and elderly non-demented cases.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Antigens; Benzothiazoles; Cerebral Cortex; Chromogranin A; Chromogranins; Fluorescent Dyes; Humans; Immunohistochemistry; Neurites; tau Proteins; Thiazoles; Ubiquitins | 1994 |
Neuritic involvement within bFGF immunopositive plaques of Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Antibodies, Monoclonal; Benzothiazoles; Biomarkers; Child; Child, Preschool; Down Syndrome; Fibroblast Growth Factor 2; Fluorescent Dyes; Heparitin Sulfate; Humans; Immunohistochemistry; Middle Aged; Nerve Fibers; Neurites; Neurofibrillary Tangles; Thiazoles | 1993 |
An important role of heparan sulfate proteoglycan (Perlecan) in a model system for the deposition and persistence of fibrillar A beta-amyloid in rat brain.
Topics: Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Congo Red; Glycosaminoglycans; Heparan Sulfate Proteoglycans; Heparitin Sulfate; Immunohistochemistry; Infusions, Parenteral; Male; Mice; Microscopy, Electron; Microscopy, Immunoelectron; Proteoglycans; Rats; Rats, Sprague-Dawley; Sarcoma, Experimental; Stereotaxic Techniques; Thiazoles; Time Factors | 1994 |
A novel hinge system and incubation chamber for emulsion-coated coverslip autoradiography.
Topics: Animals; Autoradiography; Benzothiazoles; Brain Chemistry; Cyanoacrylates; Emulsions; Fluorescence; Histological Techniques; Humans; Incubators; Macaca mulatta; Receptors, Cholinergic; Receptors, Serotonin; Thiazoles | 1993 |
Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Benzothiazoles; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Molecular Sequence Data; Molecular Structure; Protein Conformation; Solutions; Spectrometry, Fluorescence; Thiazoles | 1993 |
Alzheimer's disease-type neurofibrillary degeneration in verrucose dysplasias of the cerebral cortex.
Topics: Aged; Alzheimer Disease; Benzothiazoles; Cerebral Cortex; Cholinesterases; Female; Fluorescent Dyes; Humans; Immunohistochemistry; Male; Nerve Degeneration; Neurofibrillary Tangles; tau Proteins; Thiazoles; Tissue Fixation | 1995 |
Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: possible role of the peripheral site of the enzyme.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Benzothiazoles; Binding Sites; Brain; Butyrylcholinesterase; Cattle; Fluorescent Dyes; Humans; Mice; Microscopy, Electron; Mutation; Neurofibrils; Propidium; Recombinant Proteins; Spectrometry, Fluorescence; Thiazoles | 1996 |
Pseudoexfoliation syndrome with poorly dilating pupil: a light and electron microscopic study of the sphincter area.
Topics: Adult; Aged; Aged, 80 and over; Amyloid; Benzothiazoles; Cataract Extraction; Cytoskeletal Proteins; Exfoliation Syndrome; Female; Fibrosis; Fluorescent Dyes; Humans; Immunoenzyme Techniques; Iris; Male; Microscopy, Fluorescence; Middle Aged; Muscle, Smooth; Pupil Disorders; Thiazoles | 1996 |
First-order kinetic model of Alzheimer's beta-amyloid fibril extension in vitro.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Kinetics; Models, Biological; Peptide Fragments; Temperature; Thiazoles | 1996 |
Amyloid beta-mediated oxidative and metabolic stress in rat cortical neurons: no direct evidence for a role for H2O2 generation.
Topics: Adenosine Triphosphate; Amyloid beta-Peptides; Analysis of Variance; Animals; Benzothiazoles; Catalase; Cell Survival; Cells, Cultured; Cerebral Cortex; Coloring Agents; Fetus; Fluoresceins; Free Radical Scavengers; Glucose; Glyceraldehyde-3-Phosphate Dehydrogenases; Glycolysis; Glyoxylates; Hydrogen Peroxide; L-Lactate Dehydrogenase; Neurons; Neurotoxins; Oxazines; Oxidative Stress; Peptide Fragments; Rats; Reactive Oxygen Species; Thiazoles; Xanthenes | 1996 |
Relative efficacies of amyloid beta peptide (A beta) binding proteins in A beta aggregation.
Topics: alpha 1-Antichymotrypsin; Alzheimer Disease; Amyloid beta-Peptides; Apolipoproteins E; Benzothiazoles; Complement C1q; Humans; Prealbumin; Protein Binding; Serum Amyloid P-Component; Spectrometry, Fluorescence; Thiazoles | 1996 |
Self-assembly of the brain MAP-2 microtubule-binding region into polymeric structures resembling Alzheimer filaments.
Topics: Alzheimer Disease; Amino Acid Sequence; Animals; Benzothiazoles; Brain; Cattle; Fluorescent Dyes; Microtubule-Associated Proteins; Molecular Sequence Data; Peptide Fragments; Polymers; Protein Binding; Recombinant Proteins; Thiazoles | 1996 |
The "nonamyloidogenic" p3 fragment (amyloid beta17-42) is a major constituent of Down's syndrome cerebellar preamyloid.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Brain; Chromatography, High Pressure Liquid; Down Syndrome; Electrophoresis, Polyacrylamide Gel; Fluorometry; Humans; Mass Spectrometry; Thiazoles | 1996 |
Neurofibrillary tangles in the dentate granule cells of patients with Alzheimer's disease, Lewy body disease and progressive supranuclear palsy.
Topics: Alzheimer Disease; Antibodies, Monoclonal; Benzothiazoles; Dentate Gyrus; Fluorescent Dyes; Humans; Immunohistochemistry; Microscopy, Immunoelectron; Neurofibrillary Tangles; Parkinson Disease; Supranuclear Palsy, Progressive; Thiazoles | 1997 |
Influence of advanced glycation end-products and AGE-inhibitors on nucleation-dependent polymerization of beta-amyloid peptide.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Carnosine; Cognition; Cross-Linking Reagents; Fructose; Glycation End Products, Advanced; Guanidines; Humans; Memory; Neuropeptide Y; Particle Size; Peptide Fragments; Piperazines; Protein Structure, Secondary; Solubility; Temperature; Thiazoles; Thiophenes | 1997 |
Characterization of two highly amyloidogenic mutants of transthyretin.
Topics: Amyloid; Benzothiazoles; Chromatography, High Pressure Liquid; Fluorescent Dyes; Humans; Kinetics; Microscopy, Electron; Models, Molecular; Mutagenesis, Site-Directed; Prealbumin; Solubility; Thiazoles | 1997 |
The cellular basis for the relative resistance of parvalbumin and calretinin immunoreactive neocortical neurons to the pathology of Alzheimer's disease.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Calbindin 2; Cerebral Cortex; Cross Reactions; Fluorescent Antibody Technique; Fluorescent Dyes; Frontal Lobe; Humans; Middle Aged; Nerve Tissue Proteins; Neurites; Neurofilament Proteins; Parvalbumins; Phosphorylation; S100 Calcium Binding Protein G; Staining and Labeling; Thiazoles | 1997 |
Stopped-flow kinetics reveal multiple phases of thioflavin T binding to Alzheimer beta (1-40) amyloid fibrils.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Benzothiazoles; Binding Sites; Fluorescence; Fluorescent Dyes; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; Molecular Sequence Data; Molecular Structure; Naphthalenesulfonates; Osmolar Concentration; Peptide Fragments; Protein Binding; Protein Conformation; Protein Structure, Secondary; Sodium Chloride; Temperature; Thiazoles | 1997 |
Aggregation state-dependent activation of the classical complement pathway by the amyloid beta peptide.
Topics: Amyloid beta-Peptides; Benzothiazoles; Coloring Agents; Complement Activation; Congo Red; Fluorescent Dyes; Humans; Microscopy, Electron; Peptide Fragments; Thiazoles | 1997 |
Selective aggregation of endogenous beta-amyloid peptide and soluble amyloid precursor protein in cerebrospinal fluid by zinc.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Blotting, Western; Congo Red; Dogs; Enzyme-Linked Immunosorbent Assay; Fluorescent Dyes; Humans; Thiazoles; Zinc | 1997 |
Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease.
Topics: Aged; Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloidosis; Animals; Astrocytes; Benzothiazoles; Brain; Cerebral Amyloid Angiopathy; Humans; Mice; Mice, Inbred BALB C; Mice, Transgenic; Thiazoles; Transforming Growth Factor beta | 1997 |
ATP-promoted amyloidosis of an amyloid beta peptide.
Topics: Adenosine Triphosphate; Aluminum; Amyloid beta-Peptides; Amyloidosis; Benzothiazoles; Cells, Cultured; Fluorescent Dyes; Glucose; Humans; Nerve Fibers; Peptide Fragments; Thiazoles | 1997 |
Butyrylcholinesterase in the life cycle of amyloid plaques.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Butyrylcholinesterase; Case-Control Studies; Female; Fluorescent Dyes; Humans; Male; Middle Aged; Plaque, Amyloid; Temporal Lobe; Thiazoles | 1997 |
Pathologic amyloid beta-protein cell surface fibril assembly on cultured human cerebrovascular smooth muscle cells.
Topics: Amyloid beta-Peptides; Amyloidosis; Benzothiazoles; Cell Membrane; Cells, Cultured; Cerebral Hemorrhage; Cerebrovascular Circulation; Circular Dichroism; Coloring Agents; Congo Red; Fluorescent Dyes; Humans; Immunoblotting; Microscopy, Electron; Muscle, Smooth, Vascular; Mutation; Peptide Fragments; Thiazoles | 1998 |
Amyloidomas of the nervous system: a monoclonal B-cell disorder with monotypic amyloid light chain lambda amyloid production.
Topics: Adult; Aged; Amyloid; Amyloid Neuropathies; Amyloidosis; Antibodies; B-Lymphocytes; Benzothiazoles; beta 2-Microglobulin; Brain Diseases; Choroid Plexus; Clone Cells; Coloring Agents; Congo Red; Cranial Nerve Diseases; DNA Probes; Female; Fluorescent Dyes; Humans; Immunoglobulin kappa-Chains; Immunoglobulin lambda-Chains; Immunoglobulin Light Chains; In Situ Hybridization; Magnetic Resonance Imaging; Male; Middle Aged; Plasma Cells; Prealbumin; RNA, Messenger; Serum Amyloid A Protein; Serum Amyloid P-Component; Thiazoles; Tomography, X-Ray Computed; Trigeminal Ganglion | 1998 |
Rat microglia exhibit increased density on Alzheimer's plaques in vitro.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Benzothiazoles; Brain; Carbocyanines; Cell Count; Cells, Cultured; Fluorescent Dyes; Humans; Lipoproteins, LDL; Microglia; Middle Aged; Plaque, Amyloid; Rats; Rats, Sprague-Dawley; Reference Values; Thiazoles | 1998 |
Immunocytochemistry of formalin-fixed human brain tissues: microwave irradiation of free-floating sections.
Topics: Benzothiazoles; Brain; Fluorescent Dyes; Formaldehyde; Humans; Immunohistochemistry; Indicators and Reagents; Microtomy; Microwaves; Thiazoles; Tissue Fixation | 1998 |
A simple histological method differentiating AL-type from AA-type amyloidosis.
Topics: Adult; Aged; Aged, 80 and over; Amyloid; Amyloidosis; Benzothiazoles; Female; Fluorescent Antibody Technique, Indirect; Histocytochemistry; Histological Techniques; Humans; Kidney; Male; Middle Aged; Potassium Permanganate; Serum Amyloid A Protein; Thiazoles | 1998 |
Alpha2-macroglobulin associates with beta-amyloid peptide and prevents fibril formation.
Topics: alpha-Macroglobulins; Amyloid beta-Peptides; Benzothiazoles; Biotinylation; DNA, Complementary; HeLa Cells; Humans; Neurofibrils; Peptide Fragments; Precipitin Tests; Protease Inhibitors; Protein Binding; Thiazoles | 1998 |
The in vitro effect of lithocholic acid on the polymerization properties of PiZ alpha-1-antitrypsin.
Topics: alpha 1-Antitrypsin; Benzothiazoles; Enzyme Stability; Fluorescence; Humans; Kinetics; Lithocholic Acid; Pancreatic Elastase; Protease Inhibitors; Protein Conformation; Temperature; Thiazoles | 1998 |
Sympathetic neurite outgrowth is greater on plaque-poor vs. plaque-rich regions of Alzheimer's disease cryostat sections.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amygdala; Animals; Benzothiazoles; Case-Control Studies; Chick Embryo; Cryopreservation; Fluorescent Dyes; Humans; Neurites; Plaque, Amyloid; Sympathetic Nervous System; Thiazoles | 1998 |
The neurotoxicity of amyloid beta protein in aged primates.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Animals; Antigens; Benzothiazoles; Brain; Female; Haplorhini; Immunohistochemistry; Male; Microinjections; Microscopy, Fluorescence; Neurons; Peptide Fragments; Thiazoles; Ubiquitins | 1998 |
Laminin blocks the assembly of wild-type A beta and the Dutch variant peptide into Alzheimer's fibrils.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Amyloidosis; Benzothiazoles; Fluorescence; Kinetics; Laminin; Nephelometry and Turbidimetry; Peptide Fragments; Plaque, Amyloid; Protein Binding; Thiazoles | 1998 |
A novel assay in vitro of human islet amyloid polypeptide amyloidogenesis and effects of insulin secretory vesicle peptides on amyloid formation.
Topics: Amyloid; Benzothiazoles; C-Peptide; Cytoplasmic Granules; Diabetes Mellitus, Type 2; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Insulin; Islets of Langerhans; Kinetics; Microscopy, Electron; Peptide Fragments; Proinsulin; Temperature; Thiazoles | 1998 |
Sulfate content and specific glycosaminoglycan backbone of perlecan are critical for perlecan's enhancement of islet amyloid polypeptide (amylin) fibril formation.
Topics: Amyloid; Animals; Benzothiazoles; Coloring Agents; Congo Red; Fluorescent Dyes; Fluorometry; Glycosaminoglycans; Heparan Sulfate Proteoglycans; Heparitin Sulfate; Humans; Immunoassay; Islet Amyloid Polypeptide; Microscopy, Electron; Proteoglycans; Rats; Sarcoma, Experimental; Staining and Labeling; Thiazoles | 1998 |
Relationship between plaques, tangles, and loss of cortical cholinergic fibers in Alzheimer disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Cerebral Cortex; Choline O-Acetyltransferase; Fluorescent Dyes; Humans; Nerve Fibers; Neurofibrillary Tangles; Organ Specificity; Plaque, Amyloid; Reference Values; Regression Analysis; Thiazoles | 1998 |
Rapid assembly of Alzheimer-like paired helical filaments from microtubule-associated protein tau monitored by fluorescence in solution.
Topics: Alzheimer Disease; Benzothiazoles; Buffers; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Neurofibrillary Tangles; Polyelectrolytes; Polymers; Protein Structure, Secondary; Salts; Solutions; Spectrometry, Fluorescence; tau Proteins; Temperature; Thiazoles | 1998 |
Human recombinant NACP/alpha-synuclein is aggregated and fibrillated in vitro: relevance for Lewy body disease.
Topics: Benzothiazoles; Humans; Hydrogen-Ion Concentration; Nerve Tissue Proteins; Osmolar Concentration; Parkinson Disease; Recombinant Proteins; Synucleins; Temperature; Thiazoles; Time Factors | 1998 |
N-terminal EFRH sequence of Alzheimer's beta-amyloid peptide represents the epitope of its anti-aggregating antibodies.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Antibodies, Monoclonal; Bacteriophages; Benzothiazoles; Binding Sites, Antibody; Epitopes; Fluorescent Dyes; Peptide Fragments; Thiazoles | 1998 |
Laminin inhibits A beta 40 fibril formation promoted by apolipoprotein E4 in vitro.
Topics: Amyloid beta-Peptides; Animals; Apolipoprotein E4; Apolipoproteins E; Benzothiazoles; Fluorescent Dyes; Fluorometry; Humans; Laminin; Mice; Microscopy, Electron; Neurofibrils; Thiazoles | 1998 |
Polymerization of human prion peptide HuPrP 106-126 to amyloid in nucleic acid solution.
Topics: Amino Acid Sequence; Amyloid; Anilino Naphthalenesulfonates; Animals; Benzothiazoles; DNA; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Macromolecular Substances; Molecular Sequence Data; Peptide Fragments; Polymers; Prion Diseases; Prions; Protein Binding; Solutions; Thiazoles | 1998 |
Quantification and time course of microvascular obstruction by contrast-enhanced echocardiography and magnetic resonance imaging following acute myocardial infarction and reperfusion.
Topics: Animals; Benzothiazoles; Coloring Agents; Contrast Media; Coronary Circulation; Dogs; Echocardiography; Fluorescent Dyes; Magnetic Resonance Imaging; Microcirculation; Microspheres; Myocardial Infarction; Myocardial Reperfusion Injury; Tetrazolium Salts; Thiazoles; Time Factors | 1998 |
ApoE associated with lipid has a reduced capacity to inhibit beta-amyloid fibril formation.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloidosis; Apolipoproteins E; Benzothiazoles; Cholesterol; Fluorescent Dyes; Humans; Neurofibrillary Tangles; Thiazoles | 1998 |
Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's disease.
Topics: alpha-Synuclein; Amino Acid Substitution; Amyloid; Benzothiazoles; Biopolymers; Circular Dichroism; Dimerization; Humans; Hydrogen-Ion Concentration; Lewy Bodies; Microscopy, Electron; Mutation; Nerve Tissue Proteins; Parkinson Disease; Protein Structure, Secondary; Recombinant Proteins; Synucleins; Thiazoles | 1998 |
Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments.
Topics: alpha-Synuclein; Amyloid; Apoptosis; Benzothiazoles; Biopolymers; Cell Nucleus; Cell Survival; Circular Dichroism; Humans; Microscopy, Electron; Mutation; Nerve Tissue Proteins; Neuroblastoma; Neurodegenerative Diseases; Neurons; Parkinson Disease; Peptides; Protein Structure, Secondary; Synucleins; Thiazoles; Tumor Cells, Cultured | 1998 |
The glutamine-rich domain of the Drosophila GAGA factor is necessary for amyloid fibre formation in vitro, but not for chromatin remodelling.
Topics: Amyloid; Animals; Benzothiazoles; Binding Sites; Birefringence; Chromatin; Congo Red; DNA-Binding Proteins; Drosophila melanogaster; Drosophila Proteins; Fluorescent Dyes; Glutamine; Homeodomain Proteins; Mutagenesis; Protein Structure, Secondary; Recombinant Fusion Proteins; Structure-Activity Relationship; Thiazoles; Trans-Activators; Transcription Factors | 1999 |
Characterization of 8-epiprostaglandin F2alpha as a marker of amyloid beta-peptide-induced oxidative damage.
Topics: Amyloid beta-Peptides; Animals; Antioxidants; Benzothiazoles; Biomarkers; Cell Survival; Cells, Cultured; Dinoprost; F2-Isoprostanes; Fluorescent Dyes; Hippocampus; Hydrogen Peroxide; Kinetics; L-Lactate Dehydrogenase; Lipid Peroxidation; Neurons; Oxidants; Oxidative Stress; Peptide Fragments; Protein Conformation; Rats; Thiazoles | 1999 |
Designing conditions for in vitro formation of amyloid protofilaments and fibrils.
Topics: Acid Anhydride Hydrolases; Acylphosphatase; Amyloid; Benzothiazoles; Birefringence; Circular Dichroism; Congo Red; Fluorescent Dyes; Humans; Microscopy, Electron; Muscle, Skeletal; Protein Conformation; Spectrometry, Fluorescence; Spectrophotometry; Thiazoles | 1999 |
The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Antibodies, Monoclonal; Benzothiazoles; Brain; Brain Chemistry; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Dyes; Humans; Male; Middle Aged; Peptide Fragments; Plaque, Amyloid; Reference Values; Solubility; Thiazoles | 1999 |
The molecular chaperone alphaB-crystallin enhances amyloid beta neurotoxicity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Newborn; Apoptosis; Benzothiazoles; Cell Survival; Cells, Cultured; Cerebral Cortex; Crystallins; Dose-Response Relationship, Drug; Hippocampus; Molecular Chaperones; Neurons; Peptide Fragments; Plaque, Amyloid; Protein Binding; Protein Structure, Secondary; Rats; Thiazoles | 1999 |
Staining methods for identification of amyloid in tissue.
Topics: Amyloid; Antibodies; Benzothiazoles; Coloring Agents; Congo Red; Humans; Immunohistochemistry; Silver Staining; Staining and Labeling; Thiazoles | 1999 |
In vitro immunoglobulin light chain fibrillogenesis.
Topics: Amino Acid Sequence; Amyloid; Bence Jones Protein; Benzothiazoles; Humans; Immunoglobulin Light Chains; Molecular Sequence Data; Recombinant Proteins; Thiazoles | 1999 |
Quantification of beta-sheet amyloid fibril structures with thioflavin T.
Topics: Amyloid beta-Peptides; Benzothiazoles; Fluorescence; Hydrogen-Ion Concentration; Protein Binding; Protein Structure, Secondary; Spectrum Analysis; Thiazoles | 1999 |
Flow cytometric characterization of amyloid fibrils.
Topics: Amyloid beta-Peptides; Amyloidosis; Benzothiazoles; Flow Cytometry; Fluorescence; Humans; Thiazoles | 1999 |
Modification of beta 2-microglobulin with D-glucose or 3-deoxyglucosone inhibits A beta 2M amyloid fibril extension in vitro.
Topics: Amyloid; Amyloidosis; Benzothiazoles; beta 2-Microglobulin; Blotting, Western; Deoxyglucose; Glucose; Glycation End Products, Advanced; Humans; Immunohistochemistry; Kinetics; Male; Middle Aged; Popliteal Cyst; Spectrometry, Fluorescence; Thiazoles | 1999 |
Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy.
Topics: Age of Onset; alpha-Synuclein; Amino Acid Substitution; Amyloid; Benzothiazoles; Chromatography, Gel; Circular Dichroism; Fluorescence; Humans; Microscopy, Atomic Force; Mutation; Nerve Tissue Proteins; Parkinson Disease; Protein Conformation; Synucleins; Thiazoles; Ultracentrifugation | 2000 |
Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Apolipoproteins E; Benzothiazoles; Disease Models, Animal; Genetic Predisposition to Disease; Hippocampus; Humans; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Nerve Degeneration; Neurites; Plaque, Amyloid; Protein Isoforms; Thiazoles; Time Factors | 2000 |
Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid.
Topics: Alanine; alpha-Synuclein; Amino Acid Sequence; Amyloid; Benzothiazoles; Binding Sites; Brain; Circular Dichroism; Congo Red; Endopeptidases; Humans; Hydrolysis; Immunohistochemistry; Lewy Bodies; Microscopy, Atomic Force; Microscopy, Polarization; Molecular Sequence Data; Mutation, Missense; Nerve Tissue Proteins; Parkinson Disease; Postmortem Changes; Proline; Protein Structure, Secondary; Recombinant Proteins; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Synucleins; Thiazoles; Threonine | 2000 |
Heat-induced conformational change of human lens recombinant alphaA- and alphaB-crystallins.
Topics: Anilino Naphthalenesulfonates; Benzothiazoles; Circular Dichroism; Crystallins; DNA, Complementary; Fluorescent Dyes; Hot Temperature; Humans; Lens, Crystalline; Molecular Weight; Protein Conformation; Recombinant Proteins; Spectrometry, Fluorescence; Thiazoles; Tryptophan | 2000 |
A possible model of senile plaques using synthetic amyloid beta-protein and rat glial culture.
Topics: Amyloid beta-Peptides; Animals; Astrocytes; Benzothiazoles; Cells, Cultured; Coloring Agents; Congo Red; Fluorescent Antibody Technique; Glial Fibrillary Acidic Protein; Histocompatibility Antigens Class II; Image Processing, Computer-Assisted; Interleukin-1; Microglia; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peptide Fragments; Plaque, Amyloid; Rats; Rats, Sprague-Dawley; Staining and Labeling; Thiazoles | 2000 |
Preparation of synthetic human islet amyloid polypeptide (IAPP) in a stable conformation to enable study of conversion to amyloid-like fibrils.
Topics: Amino Acid Sequence; Amyloid; Animals; Benzothiazoles; Circular Dichroism; Humans; Islet Amyloid Polypeptide; Molecular Sequence Data; Propanols; Protein Structure, Secondary; Rats; Solubility; Spectrum Analysis; Thiazoles; Trifluoroethanol | 2000 |
Orbitofrontal cortex pathology in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Fluorescent Dyes; Frontal Lobe; Humans; Middle Aged; Neurofibrillary Tangles; Organ Size; Plaque, Amyloid; Thiazoles | 2000 |
High density lipoprotein inhibits assembly of amyloid beta-peptides into fibrils.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Fluorescent Dyes; Fluorometry; Humans; Lipoproteins, HDL; Nerve Tissue Proteins; Particle Size; Peptide Fragments; Plaque, Amyloid; Protein Binding; Solubility; Thiazoles | 2000 |
Inhibition of toxicity in the beta-amyloid peptide fragment beta -(25-35) using N-methylated derivatives: a general strategy to prevent amyloid formation.
Topics: Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Death; Coloring Agents; Congo Red; Dose-Response Relationship, Drug; Fluorescent Dyes; Methylation; Microscopy, Electron; PC12 Cells; Peptide Biosynthesis; Peptide Fragments; Protein Binding; Protein Conformation; Protein Folding; Protein Structure, Secondary; Rats; Spectrophotometry; Tetrazolium Salts; Thiazoles | 2000 |
Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy.
Topics: Animals; Antibodies, Monoclonal; Benzoates; Benzothiazoles; Biphenyl Compounds; Congo Red; COS Cells; Gossypol; Humans; Huntingtin Protein; Huntington Disease; Melatonin; Nerve Tissue Proteins; Nuclear Proteins; Peptides; Rifampin; Thiazoles | 2000 |
Removal of the N-terminal hexapeptide from human beta2-microglobulin facilitates protein aggregation and fibril formation.
Topics: Amino Acid Sequence; Amyloid; Benzothiazoles; beta 2-Microglobulin; Chromatography, Gel; Circular Dichroism; DNA, Complementary; Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Light; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Molecular; Molecular Sequence Data; Protein Conformation; Protein Structure, Secondary; Recombinant Proteins; Scattering, Radiation; Temperature; Thermodynamics; Thiazoles; Time Factors | 2000 |
Human apolipoprotein C-II forms twisted amyloid ribbons and closed loops.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Apolipoprotein C-II; Apolipoproteins C; Benzothiazoles; Chromatography, Gel; Circular Dichroism; Congo Red; Humans; Microscopy, Electron; Protein Conformation; Spectrometry, Fluorescence; Thiazoles; Tryptophan; Ultracentrifugation | 2000 |
A systematic exploration of the influence of the protein stability on amyloid fibril formation in vitro.
Topics: Amyloid; Benzothiazoles; Circular Dichroism; Congo Red; Microscopy, Electron; Protein Binding; Protein Denaturation; Proteins; Thermodynamics; Thiazoles | 2000 |
Partially unfolded states of beta(2)-microglobulin and amyloid formation in vitro.
Topics: Amino Acid Sequence; Amyloid; Amyloid beta-Protein Precursor; Amyloidosis; Anilino Naphthalenesulfonates; Benzothiazoles; beta 2-Microglobulin; Circular Dichroism; Coloring Agents; Congo Red; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Osmolar Concentration; Protein Conformation; Protein Folding; Recombinant Proteins; Spectrometry, Fluorescence; Thiazoles; X-Ray Diffraction | 2000 |
The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity.
Topics: alpha-Synuclein; Benzothiazoles; Cell Survival; Free Radicals; Humans; Inclusion Bodies; Iron; Lewy Bodies; Mutation; Nerve Tissue Proteins; Neuroblastoma; Neurons; Oxidative Stress; Parkinson Disease; Synucleins; Thiazoles; Tumor Cells, Cultured; Ubiquitins | 2000 |
Studies on the in vitro assembly of a beta 1-40: implications for the search for a beta fibril formation inhibitors.
Topics: Amyloid beta-Peptides; Benzothiazoles; Congo Red; Dimerization; Dimethyl Sulfoxide; Fluorescent Dyes; Freeze Drying; Humans; Microscopy, Electron; Molecular Weight; Nephelometry and Turbidimetry; Polymers; Temperature; Thiazoles; Time Factors | 2000 |
Inhibition of beta-amyloid-induced neurotoxicity by imidazopyridoindoles derived from a synthetic combinatorial library.
Topics: Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Death; Circular Dichroism; Combinatorial Chemistry Techniques; Dimerization; Fluorescent Dyes; Humans; Indoles; Inhibitory Concentration 50; Nervous System Diseases; Neurotoxins; PC12 Cells; Peptides; Protein Structure, Secondary; Rats; Spectrometry, Fluorescence; Structure-Activity Relationship; Thiazoles | 2000 |
Amyloid fibril formation from full-length and fragments of amylin.
Topics: Amyloid; Animals; Base Sequence; Benzothiazoles; Circular Dichroism; Fluorescent Dyes; Humans; Islet Amyloid Polypeptide; Microscopy, Electron; Molecular Sequence Data; Molecular Weight; Peptide Fragments; Protein Structure, Secondary; Rats; Sequence Alignment; Thiazoles | 2000 |
X-34, a fluorescent derivative of Congo red: a novel histochemical stain for Alzheimer's disease pathology.
Topics: Aged; Aged, 80 and over; Alkenes; Alzheimer Disease; Amyloid; Amyloidosis; Benzoates; Benzothiazoles; Coloring Agents; Congo Red; Female; Fluorescent Dyes; Histocytochemistry; Humans; Male; Middle Aged; Neurofibrillary Tangles; Plaque, Amyloid; Protein Structure, Secondary; Silver; Thiazoles | 2000 |
Amyloid-like protein structure in mammalian ocular lenses.
Topics: Amyloid; Animals; Benzothiazoles; Birefringence; Coloring Agents; Congo Red; Fluorescence; Lens, Crystalline; Mice; Microscopy, Fluorescence; Reference Values; Staining and Labeling; Thiazoles | 2000 |
Secondary cutaneous amyloidosis in disseminated superficial porokeratosis: a case report.
Topics: Aged; Aged, 80 and over; Amyloid; Amyloidosis; Benzothiazoles; Coloring Agents; Congo Red; Epidermis; Humans; Male; Porokeratosis; Pruritus; Skin Diseases; Staining and Labeling; Thiazoles; Tuberculosis, Pulmonary | 2000 |
Structure, microtubule interactions, and paired helical filament aggregation by tau mutants of frontotemporal dementias.
Topics: Actin Cytoskeleton; Benzothiazoles; Circular Dichroism; Dementia; Humans; Microscopy, Electron; Microtubules; Mutagenesis, Site-Directed; Mutation; Mutation, Missense; Neuropil Threads; Paclitaxel; Protein Binding; Protein Structure, Secondary; Scattering, Radiation; Sequence Deletion; Spectrometry, Fluorescence; tau Proteins; Thiazoles | 2000 |
The molecular interaction of 4'-iodo-4'-deoxydoxorubicin with Leu-55Pro transthyretin 'amyloid-like' oligomer leading to disaggregation.
Topics: Amino Acid Substitution; Amyloidosis; Benzothiazoles; Crystallization; Doxorubicin; Humans; Iodine; Leucine; Models, Molecular; Prealbumin; Proline; Protein Binding; Protein Structure, Secondary; Thiazoles; X-Ray Diffraction | 2000 |
Laminin inhibition of beta-amyloid protein (Abeta) fibrillogenesis and identification of an Abeta binding site localized to the globular domain repeats on the laminin a chain.
Topics: Amyloid; Amyloid beta-Peptides; Basement Membrane; Benzothiazoles; Binding Sites; Dose-Response Relationship, Drug; Fluorometry; Immunoassay; Islet Amyloid Polypeptide; Laminin; Microscopy, Electron; Negative Staining; Peptide Fragments; Protein Binding; Protein Structure, Tertiary; Repetitive Sequences, Amino Acid; Thiazoles | 2000 |
Interaction between beta-amyloid and lens alphaB-crystallin.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Circular Dichroism; Crystallins; Humans; Recombinant Proteins; Spectrometry, Fluorescence; Thiazoles; Tryptophan; Ultraviolet Rays | 2000 |
Growth arrest of individual senile plaques in a model of Alzheimer's disease observed by in vivo multiphoton microscopy.
Topics: Alzheimer Disease; Animals; Benzothiazoles; Disease Models, Animal; Disease Progression; Feedback; Fluorescent Dyes; Image Processing, Computer-Assisted; Male; Mice; Mice, Transgenic; Microscopy; Plaque, Amyloid; Thiazoles | 2001 |
Regional distribution of amyloid-Bri deposition and its association with neurofibrillary degeneration in familial British dementia.
Topics: Adaptor Proteins, Signal Transducing; Amyloid; Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Benzothiazoles; Blood Vessels; Central Nervous System; Congo Red; Glial Fibrillary Acidic Protein; Heredodegenerative Disorders, Nervous System; Humans; Immunoblotting; Immunohistochemistry; Membrane Glycoproteins; Membrane Proteins; Microscopy, Immunoelectron; Peptide Fragments; Staining and Labeling; tau Proteins; Thiazoles | 2001 |
Spectroscopic evidence for amyloid-like interfacial self-assembly of hydrophobin Sc3.
Topics: Amyloid beta-Peptides; Animals; Benzothiazoles; Cattle; Congo Red; Fungal Proteins; Peptide Fragments; Protein Structure, Secondary; Schizophyllum; Serum Albumin, Bovine; Spectrometry, Fluorescence; Spectrophotometry; Thiazoles | 2001 |
Anti-amyloidogenic activity of tetracyclines: studies in vitro.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Doxycycline; Fluorescent Dyes; Humans; Hydrolysis; In Vitro Techniques; Macromolecular Substances; Microscopy, Electron; Peptide Fragments; Tetracycline; Tetracyclines; Thiazoles; Trypsin | 2001 |
Complement association with neurons and beta-amyloid deposition in the brains of aged individuals with Down Syndrome.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Brain; Complement C1q; Down Syndrome; Encephalitis; Female; Humans; Immunohistochemistry; Male; Microglia; Middle Aged; Neurofibrillary Tangles; Neurons; Plaque, Amyloid; Thiazoles | 2001 |
Thioflavin T is a fluorescent probe of the acetylcholinesterase peripheral site that reveals conformational interactions between the peripheral and acylation sites.
Topics: Acetophenones; Acetylcholinesterase; Acylation; Benzothiazoles; Binding Sites; Cholinesterase Inhibitors; Coloring Agents; Dose-Response Relationship, Drug; Edrophonium; Fluorescent Dyes; Humans; Propidium; Protein Conformation; Thiazoles | 2001 |
Identification of a novel human islet amyloid polypeptide beta-sheet domain and factors influencing fibrillogenesis.
Topics: Amino Acid Sequence; Amino Acid Substitution; Amyloid; Amyloidosis; Animals; Benzothiazoles; Circular Dichroism; Diabetes Mellitus, Type 2; Humans; Hydrogen-Ion Concentration; Islet Amyloid Polypeptide; Islets of Langerhans; Microscopy, Electron; Molecular Sequence Data; Peptide Fragments; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Spectroscopy, Fourier Transform Infrared; Thiazoles; X-Ray Diffraction | 2001 |
The relationship between Abeta-associated free radical generation and Abeta fibril formation revealed by negative stain electron microscopy and thioflavine-T fluorometric assay.
Topics: Amyloid beta-Peptides; Benzothiazoles; Electron Spin Resonance Spectroscopy; Fluorescent Dyes; Fluorometry; Free Radicals; Microscopy, Electron; Negative Staining; Peptide Fragments; Thiazoles | 2001 |
Effect of environmental factors on the kinetics of insulin fibril formation: elucidation of the molecular mechanism.
Topics: Anilino Naphthalenesulfonates; Animals; Anions; Benzothiazoles; Cattle; Chemistry, Physical; Excipients; Fluorescent Dyes; Hydrogen-Ion Concentration; Insulin; Kinetics; Methylamines; Models, Chemical; Osmolar Concentration; Protein Denaturation; Salts; Sonication; Sucrose; Surface Properties; Thiazoles; Urea | 2001 |
Promotion of formation of amyloid fibrils by aluminium adenosine triphosphate (AlATP).
Topics: Adenosine; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Fluorescent Dyes; Humans; Islet Amyloid Polypeptide; Organometallic Compounds; Suramin; Thiazoles | 2001 |
The relationship between the aggregational state of the amyloid-beta peptides and free radical generation by the peptides.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Survival; Circular Dichroism; Electron Spin Resonance Spectroscopy; Fluorescent Dyes; Free Radicals; Humans; PC12 Cells; Rats; Thiazoles | 2001 |
Conformational characterization of oligomeric intermediates and aggregates in beta-lactoglobulin heat aggregation.
Topics: Animals; Benzothiazoles; Circular Dichroism; Dimerization; Hot Temperature; Humans; Lactoglobulins; Microscopy, Electron; Oligopeptides; Particle Size; Protein Conformation; Protein Folding; Spectrometry, Fluorescence; Thiazoles | 2001 |
Fibrillar beta-amyloid evokes oxidative damage in a transgenic mouse model of Alzheimer's disease.
Topics: Aging; Aldehydes; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Disease Models, Animal; Immunohistochemistry; Mice; Mice, Neurologic Mutants; Mice, Transgenic; Nerve Degeneration; Neurofibrillary Tangles; Oxidative Stress; Thiazoles; Tyrosine | 2001 |
Inhibition of beta-amyloid(40) fibrillogenesis and disassembly of beta-amyloid(40) fibrils by short beta-amyloid congeners containing N-methyl amino acids at alternate residues.
Topics: Alzheimer Disease; Amino Acid Sequence; Amino Acids; Amyloid beta-Peptides; Benzothiazoles; Chymotrypsin; Drug Resistance; Humans; Methylation; Microscopy, Fluorescence; Molecular Sequence Data; Peptide Fragments; Protein Structure, Secondary; Protein Structure, Tertiary; Thiazoles; Ultracentrifugation | 2001 |
The molecular chaperone, alpha-crystallin, inhibits amyloid formation by apolipoprotein C-II.
Topics: Amyloid; Animals; Apolipoprotein C-II; Apolipoproteins C; Benzothiazoles; Cattle; Cell Nucleus; Chromatography, Gel; Circular Dichroism; Crystallins; Fluorescent Dyes; Kinetics; Lens, Crystalline; Models, Biological; Protein Binding; Protein Conformation; Thiazoles; Time Factors; Ultracentrifugation | 2001 |
Multiple ligand interaction of alpha-synuclein produced various forms of protein aggregates in the presence of Abeta25-35, copper, and eosin.
Topics: alpha-Synuclein; Amyloid beta-Peptides; Benzothiazoles; Cells, Cultured; Copper; Eosine Yellowish-(YS); Fluorescent Dyes; Ligands; Microscopy, Electron; Nerve Tissue Proteins; Neurodegenerative Diseases; Peptide Fragments; Polymers; Protein Structure, Tertiary; Synucleins; Thiazoles | 2001 |
Statistical aspects of quantitative image analysis of beta-amyloid in the APP(V717F) transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Cell Count; Data Interpretation, Statistical; Disease Models, Animal; Hippocampus; Image Processing, Computer-Assisted; Male; Mice; Mice, Transgenic; Microscopy, Fluorescence; Plaque, Amyloid; Reproducibility of Results; Statistical Distributions; Thiazoles | 2001 |
The morphological phenotype of beta-amyloid plaques and associated neuritic changes in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Cerebral Cortex; Fluorescent Dyes; Humans; Immunohistochemistry; Microscopy, Confocal; Nerve Degeneration; Neurites; Neurofilament Proteins; Phenotype; Plaque, Amyloid; tau Proteins; Thiazoles | 2001 |
Plaque-induced abnormalities in neurite geometry in transgenic models of Alzheimer disease: implications for neural system disruption.
Topics: Action Potentials; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Dendrites; In Vitro Techniques; Mice; Mice, Transgenic; Microscopy, Confocal; Models, Neurological; Neurites; Plaque, Amyloid; Reaction Time; Thiazoles | 2001 |
Role of the single disulphide bond of beta(2)-microglobulin in amyloidosis in vitro.
Topics: Amyloid; Amyloidosis; Benzothiazoles; beta 2-Microglobulin; Circular Dichroism; Disulfides; Humans; Hydrogen-Ion Concentration; Microscopy, Electron; Models, Molecular; Osmolar Concentration; Oxidation-Reduction; Protein Structure, Secondary; Protein Structure, Tertiary; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Thiazoles | 2001 |
Neuroinflammation-induced acceleration of amyloid deposition in the APPV717F transgenic mouse.
Topics: Amyloid; Amyloid beta-Protein Precursor; Animals; Apolipoproteins E; Benzothiazoles; Encephalitis; Fluorescent Dyes; Immunohistochemistry; Injections, Intraventricular; Lipopolysaccharides; Male; Mice; Mice, Transgenic; Neuroglia; RNA, Messenger; Thiazoles | 2001 |
Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Chemical Phenomena; Chemistry, Physical; Female; Fluorescent Dyes; Histocytochemistry; Hydrogen-Ion Concentration; Mice; Protein Binding; Solubility; Spectrometry, Fluorescence; Thiazoles; Tomography, Emission-Computed | 2001 |
Plasmin cleaves Abeta42 in vitro and prevents its aggregation into beta-pleated sheet structures.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Brain; Chromatography, High Pressure Liquid; Drug Interactions; Fibrinolysin; Humans; Peptide Fragments; Protein Structure, Secondary; Thiazoles | 2001 |
A partially structured species of beta 2-microglobulin is significantly populated under physiological conditions and involved in fibrillogenesis.
Topics: Benzothiazoles; beta 2-Microglobulin; Circular Dichroism; Coloring Agents; Congo Red; Electrophoresis, Capillary; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Kinetics; Light; Microscopy, Electron; Models, Biological; Models, Chemical; Protein Conformation; Protein Denaturation; Protein Folding; Scattering, Radiation; Temperature; Thiazoles; Time Factors; Ultraviolet Rays | 2001 |
Relationship of calbindin D28K-immunoreactive cells and neuropathological changes in the hippocampal formation of Alzheimer's disease.
Topics: Age of Onset; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Benzothiazoles; Calbindin 1; Calbindins; Female; Fluorescent Dyes; Hippocampus; Humans; Immunohistochemistry; Male; Middle Aged; Neurofibrillary Tangles; Plaque, Amyloid; Pyramidal Cells; S100 Calcium Binding Protein G; Thiazoles | 2001 |
Investigation of a peptide responsible for amyloid fibril formation of beta 2-microglobulin by achromobacter protease I.
Topics: Amino Acid Sequence; Amyloid; Benzothiazoles; beta 2-Microglobulin; Circular Dichroism; Fluorescent Dyes; Humans; Models, Biological; Models, Molecular; Molecular Sequence Data; Peptide Fragments; Polymers; Protein Structure, Secondary; Recombinant Proteins; Serine Endopeptidases; Thiazoles; Time Factors | 2002 |
Vasculopathy and amyloid beta reactivity in brains of patients with acquired immune deficiency (AIDS).
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS Dementia Complex; AIDS-Related Opportunistic Infections; Amyloid beta-Peptides; Axons; Benzothiazoles; Brain; Brain Chemistry; Brain Neoplasms; Cerebral Arteries; Cerebral Veins; Cerebrovascular Circulation; Coloring Agents; Congo Red; Female; Humans; Leukoencephalopathy, Progressive Multifocal; Lymphoma, AIDS-Related; Lymphoma, B-Cell; Male; Meningitis, Cryptococcal; Middle Aged; Plaque, Amyloid; Thiazoles; Toxoplasmosis, Cerebral; Ubiquitin; Vasculitis | 2000 |
Solution conditions can promote formation of either amyloid protofilaments or mature fibrils from the HypF N-terminal domain.
Topics: Amyloid; Amyloid beta-Peptides; Bacterial Proteins; Benzothiazoles; Circular Dichroism; Cloning, Molecular; Coloring Agents; Congo Red; Escherichia coli; Fluorescent Dyes; Hot Temperature; Hydrogen-Ion Concentration; Microscopy, Electron; Protein Structure, Tertiary; Thiazoles; Time Factors; Trifluoroethanol; Urea | 2001 |
Formation of filamentous tau aggregations in transgenic mice expressing V337M human tau.
Topics: Animals; Benzothiazoles; Brain; Cerebral Cortex; Coloring Agents; Congo Red; Disease Models, Animal; Female; Gene Expression Regulation; Hippocampus; Humans; Immunohistochemistry; Male; Mice; Mice, Neurologic Mutants; Mice, Transgenic; Microscopy, Electron; Mutation, Missense; Neurodegenerative Diseases; Neurofibrillary Tangles; Neurons; Protein Structure, Secondary; tau Proteins; Thiazoles; Transfection; Ubiquitin | 2001 |
Early formation of mature amyloid-beta protein deposits in a mutant APP transgenic model depends on levels of Abeta(1-42).
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Brain; Congo Red; Disease Models, Animal; Gene Expression Regulation, Developmental; Mice; Mice, Neurologic Mutants; Mice, Transgenic; Microscopy, Electron; Mutagenesis, Insertional; Mutation; Neurites; Neurons; Peptide Fragments; Plaque, Amyloid; Presynaptic Terminals; Promoter Regions, Genetic; Thiazoles | 2001 |
Macromolecular crowding accelerates amyloid formation by human apolipoprotein C-II.
Topics: Amyloid; Apolipoprotein C-II; Apolipoproteins C; Benzothiazoles; Circular Dichroism; Coloring Agents; Congo Red; Dextrans; Dose-Response Relationship, Drug; Electric Conductivity; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Kinetics; Lipids; Microscopy, Electron; Protein Binding; Protein Conformation; Protein Structure, Secondary; Recombinant Proteins; Thermodynamics; Thiazoles; Time Factors; Ultracentrifugation | 2002 |
A designed system for assessing how sequence affects alpha to beta conformational transitions in proteins.
Topics: Algorithms; Amino Acid Sequence; Amyloid; Benzothiazoles; Circular Dichroism; Microscopy, Electron; Models, Chemical; Models, Theoretical; Molecular Sequence Data; Oxygen; Peptide Biosynthesis; Peptides; Protein Binding; Protein Conformation; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Sequence Homology, Amino Acid; Temperature; Thiazoles; Threonine; Ultracentrifugation | 2002 |
Inhibitors of fibril formation and cytotoxicity of beta-amyloid peptide composed of KLVFF recognition element and flexible hydrophilic disrupting element.
Topics: Amyloid beta-Peptides; Benzothiazoles; Cell Division; Cell Survival; Coloring Agents; Congo Red; Enzyme Inhibitors; Fluorescent Dyes; Humans; Models, Chemical; Peptide Fragments; Peptides; Pigments, Biological; Protein Binding; Protein Structure, Tertiary; Tetrazolium Salts; Thiazoles; Time Factors; Tumor Cells, Cultured | 2002 |
Kinetic partitioning of protein folding and aggregation.
Topics: Acid Anhydride Hydrolases; Acylphosphatase; Amino Acid Sequence; Benzothiazoles; Chromatography, Gel; Circular Dichroism; Fluorescence; Humans; Hydrophobic and Hydrophilic Interactions; Kinetics; Models, Molecular; Molecular Sequence Data; Muscles; Peptide Fragments; Point Mutation; Protein Binding; Protein Denaturation; Protein Folding; Protein Structure, Quaternary; Protein Structure, Secondary; Solubility; Thiazoles | 2002 |
A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain.
Topics: Alzheimer Disease; Amyloid; Animals; Benzothiazoles; Binding, Competitive; Brain; Chemical Phenomena; Chemistry, Physical; Mice; Mice, Transgenic; Microscopy; Plaque, Amyloid; Radiopharmaceuticals; Structure-Activity Relationship; Thiazoles; Tomography, Emission-Computed | 2002 |
Human stefin B readily forms amyloid fibrils in vitro.
Topics: Amyloid beta-Peptides; Animals; Benzothiazoles; Buffers; Coloring Agents; Congo Red; Cystatin B; Cystatins; Cysteine Proteinase Inhibitors; Humans; Hydrogen-Ion Concentration; Microscopy, Atomic Force; Microscopy, Electron; Protein Conformation; Recombinant Proteins; Thiazoles; X-Ray Diffraction | 2002 |
Heterogeneous assembly of complementary peptide pairs into amyloid fibrils with alpha-beta structural transition.
Topics: Amyloid beta-Peptides; Benzothiazoles; Circular Dichroism; Microscopy, Electron; Peptides; Protein Conformation; Protein Engineering; Thiazoles | 2001 |
Amyloid-beta deposits in the cerebral cortex of the aged common marmoset (Callithrix jacchus): incidence and chemical composition.
Topics: Aging; alpha 1-Antichymotrypsin; Amyloid beta-Peptides; Animals; Apolipoproteins E; Benzothiazoles; Brain Diseases; Callithrix; Cerebral Cortex; Cholinesterases; Disease Models, Animal; Female; Incidence; Male; Neurites; Peptide Fragments; Plaque, Amyloid; Survival Analysis; Thiazoles | 2002 |
A liposome-based therapeutic vaccine against beta -amyloid plaques on the pancreas of transgenic NORBA mice.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Benzothiazoles; Enzyme-Linked Immunosorbent Assay; Immune Sera; Immunity; Liposomes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Molecular Sequence Data; Palmitic Acid; Pancreas; Peptides; Species Specificity; Thiazoles; Time Factors; Vaccines | 2002 |
Familial Danish dementia: a novel form of cerebral amyloidosis associated with deposition of both amyloid-Dan and amyloid-beta.
Topics: Adult; Amyloid beta-Peptides; Amyloidosis; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Benzothiazoles; Blood Vessels; Brain Diseases; Coloring Agents; Congo Red; Dementia; Denmark; Female; Fluorescent Dyes; Glial Fibrillary Acidic Protein; Histocompatibility Antigens Class II; Humans; Immunoblotting; Immunohistochemistry; Male; Microscopy, Electron; Microscopy, Immunoelectron; Middle Aged; Pedigree; Staining and Labeling; tau Proteins; Thiazoles | 2002 |
Type IV collagen prevents amyloid beta-protein fibril formation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Circular Dichroism; Collagen Type IV; Dose-Response Relationship, Drug; Fluorescent Dyes; Humans; Microscopy, Electron; Peptide Fragments; Spectrometry, Fluorescence; Thiazoles | 2002 |
Prion peptide 106-126 as a model for prion replication and neurotoxicity.
Topics: Benzothiazoles; Cell Line; Detergents; Fluorescent Dyes; Humans; Membrane Proteins; Microscopy, Fluorescence; Models, Biological; Mutation; Neurons; Peptide Fragments; Prion Diseases; Prions; Protein Transport; PrPC Proteins; Solubility; Thiazoles; Tumor Cells, Cultured | 2002 |
Comparative analysis of an improved thioflavin-s stain, Gallyas silver stain, and immunohistochemistry for neurofibrillary tangle demonstration on the same sections.
Topics: Aged; Aged, 80 and over; Antibodies, Monoclonal; Benzothiazoles; Humans; Immunohistochemistry; Microtomy; Neurofibrillary Tangles; Sensitivity and Specificity; Silver Staining; Thiazoles | 2002 |
A protein sequence that can encode native structure by disfavoring alternate conformations.
Topics: Amino Acid Sequence; Benzothiazoles; Cell Line; Cell Membrane; Circular Dichroism; Computational Biology; Cystic Fibrosis Transmembrane Conductance Regulator; Genome; Humans; Liposomes; Micelles; Molecular Sequence Data; Mutation; Proline; Protein Folding; Protein Structure, Secondary; Recombinant Fusion Proteins; Spectroscopy, Fourier Transform Infrared; Structure-Activity Relationship; Thermodynamics; Thiazoles | 2002 |
Conformation of beta 2-microglobulin amyloid fibrils analyzed by reduction of the disulfide bond.
Topics: Amyloid; Benzothiazoles; beta 2-Microglobulin; Chromatography, High Pressure Liquid; Circular Dichroism; Crystallography, X-Ray; Cysteine; Disulfides; Humans; Hydrogen-Ion Concentration; Microscopy, Electron; Models, Molecular; Protein Binding; Protein Conformation; Protein Folding; Recombinant Proteins; Spectrometry, Fluorescence; Thiazoles | 2002 |
Kinetics and energetics of assembly, nucleation, and growth of aggregates and fibrils for an amyloidogenic protein. Insights into transition states from pressure, temperature, and co-solute studies.
Topics: Amyloid; Benzothiazoles; Chromatography, High Pressure Liquid; Coloring Agents; Congo Red; Humans; Immunoglobulin Light Chains; Kinetics; Microscopy, Electron; Microscopy, Fluorescence; Pressure; Protein Binding; Protein Folding; Protein Structure, Tertiary; Spectroscopy, Fourier Transform Infrared; Temperature; Thermodynamics; Thiazoles; Time Factors; Ultraviolet Rays; Urea | 2002 |
Substitution of isoleucine-31 by helical-breaking proline abolishes oxidative stress and neurotoxic properties of Alzheimer's amyloid beta-peptide.
Topics: Amino Acid Substitution; Amyloid beta-Peptides; Animals; Benzothiazoles; Circular Dichroism; Copper; Isoleucine; Microscopy, Electron; Neurons; Oxidative Stress; Peptide Fragments; Proline; Rats; Thiazoles | 2002 |
Amyloid-like features of polyglutamine aggregates and their assembly kinetics.
Topics: Amyloid beta-Peptides; Antibodies, Monoclonal; Benzothiazoles; Binding Sites, Antibody; Fluorescent Dyes; Freezing; Glutamine; Hot Temperature; Humans; Huntington Disease; Kinetics; Microscopy, Electron; Peptides; Protein Binding; Solubility; Thiazoles | 2002 |
Suppression of apolipoprotein C-II amyloid formation by the extracellular chaperone, clusterin.
Topics: Amyloid; Apolipoprotein C-II; Apolipoproteins C; Benzothiazoles; Clusterin; Glycoproteins; Humans; Molecular Chaperones; Thiazoles | 2002 |
Synthesis, aggregation, neurotoxicity, and secondary structure of various A beta 1-42 mutants of familial Alzheimer's disease at positions 21-23.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Benzothiazoles; Cerebral Amyloid Angiopathy; Chromatography, High Pressure Liquid; Formazans; Humans; Molecular Sequence Data; PC12 Cells; Peptide Fragments; Protein Conformation; Protein Structure, Secondary; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Structure-Activity Relationship; Thiazoles | 2002 |
Amyloid fibrils from the mammalian protein prothymosin alpha.
Topics: Amyloid beta-Peptides; Benzothiazoles; Circular Dichroism; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Kinetics; Microscopy, Atomic Force; Microscopy, Electron; Protein Folding; Protein Precursors; Protein Structure, Secondary; Spectrometry, Fluorescence; Thiazoles; Thymosin | 2002 |
Nordihydroguaiaretic acid potently breaks down pre-formed Alzheimer's beta-amyloid fibrils in vitro.
Topics: Amyloid beta-Peptides; Benzothiazoles; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Humans; Kidney; Macromolecular Substances; Masoprocol; Microscopy, Electron; Peptide Fragments; Protein Binding; Spectrometry, Fluorescence; Thiazoles | 2002 |
Concurrence of alpha-synuclein and tau brain pathology in the Contursi kindred.
Topics: Adult; alpha-Synuclein; Archives; Benzothiazoles; Brain; Fluorescent Antibody Technique; Fluorescent Dyes; Humans; Male; Microscopy, Immunoelectron; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Parkinson Disease; Synucleins; tau Proteins; Thiazoles | 2002 |
Fibrillar inclusions and motor neuron degeneration in transgenic mice expressing superoxide dismutase 1 with a disrupted copper-binding site.
Topics: Amino Acid Substitution; Animals; Benzothiazoles; Binding Sites; Copper; Disease Models, Animal; Female; Histidine; Humans; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Transgenic; Motor Neuron Disease; Motor Neurons; Mutation, Missense; Nerve Tissue Proteins; Neurofibrils; Protein Folding; Spinal Cord; Structure-Activity Relationship; Superoxide Dismutase; Superoxides; Thiazoles | 2002 |
Amyloid formation in rat transthyretin: effect of oxidative stress.
Topics: Amyloid; Animals; Benzothiazoles; Chromatography, Affinity; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Hydrogen-Ion Concentration; Male; Microscopy, Electron; Oxidative Stress; Paraquat; Prealbumin; Protein Processing, Post-Translational; Rats; Rats, Wistar; Sequence Analysis, Protein; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiazoles | 2002 |
A novel compound, RS-1178, specifically inhibits neuronal cell death mediated by beta-amyloid-induced macrophage activation in vitro.
Topics: Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Death; Cells, Cultured; Cerebellum; Coculture Techniques; Fluorescent Dyes; Immunohistochemistry; L-Lactate Dehydrogenase; Macrophage Activation; Macrophages, Peritoneal; Mice; Mice, Inbred C3H; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinases; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Phosphorylation; Pyrimidines; Rats; Rats, Sprague-Dawley; Thiazoles; Tumor Necrosis Factor-alpha | 2002 |
Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Brain; Clusterin; Disease Models, Animal; Glycoproteins; Mice; Mice, Knockout; Molecular Chaperones; Neurites; Peptide Fragments; Plaque, Amyloid; Thiazoles | 2002 |
Disassembly of amyloid beta-protein fibril by basement membrane components.
Topics: Amyloid beta-Peptides; Basement Membrane; Benzothiazoles; Circular Dichroism; Collagen Type IV; Fluorescent Dyes; Fluorometry; Humans; Laminin; Membrane Glycoproteins; Microscopy, Electron; Thiazoles | 2002 |
Circumvention of chaperone requirement for aggregate formation of a short polyglutamine tract by the co-expression of a long polyglutamine tract.
Topics: Amino Acid Sequence; Amyloidosis; Base Sequence; Benzothiazoles; Fluorescent Antibody Technique; Fluorescent Dyes; Genetic Vectors; Humans; Molecular Chaperones; Molecular Sequence Data; NF-kappa B; Peptides; Plasmids; Polydeoxyribonucleotides; Recombinant Proteins; Thiazoles | 2002 |
New class of inhibitors of amyloid-beta fibril formation. Implications for the mechanism of pathogenesis in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Apomorphine; Benzothiazoles; Fluorescent Dyes; Humans; Hydroxylation; Kinetics; Microscopy, Electron; Models, Biological; Protein Structure, Quaternary; Thiazoles | 2002 |
Microvascular reperfusion injury: rapid expansion of anatomic no reflow during reperfusion in the rabbit.
Topics: Animals; Benzothiazoles; Coronary Circulation; Fluorescent Dyes; Hemorrhage; Male; Microcirculation; Myocardial Infarction; Myocardial Reperfusion; Myocardial Reperfusion Injury; Rabbits; Thiazoles | 2002 |
Synthesis of (-)-5,8-dihydroxy-3R-methyl-2R-(dipropylamino)-1,2,3,4-tetrahydronaphthalene: an inhibitor of beta-amyloid(1-42) aggregation.
Topics: Amyloid beta-Peptides; Antioxidants; Benzothiazoles; Chromatography, High Pressure Liquid; Crystallization; Crystallography, X-Ray; Fluorescent Dyes; Hydroquinones; Indicators and Reagents; Magnetic Resonance Spectroscopy; Peptide Fragments; Stereoisomerism; Structure-Activity Relationship; Tetrahydronaphthalenes; Thiazoles | 2002 |
DNA-induced partial unfolding of prion protein leads to its polymerisation to amyloid.
Topics: Amyloid; Anilino Naphthalenesulfonates; Animals; Benzothiazoles; Biopolymers; Birefringence; Circular Dichroism; Congo Red; DNA; Fluorescence; Hydrophobic and Hydrophilic Interactions; Mice; Microscopy, Electron; Peptide Fragments; Prions; Protein Binding; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Spectrometry, Fluorescence; Temperature; Thiazoles; Tryptophan | 2002 |
Dependence of alpha-synuclein aggregate morphology on solution conditions.
Topics: alpha-Synuclein; Benzothiazoles; Circular Dichroism; Humans; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Ions; Kinetics; Magnesium; Microscopy, Atomic Force; Microscopy, Electron; Nerve Tissue Proteins; Osmolar Concentration; Protein Binding; Protein Structure, Quaternary; Sodium; Solutions; Synucleins; Thiazoles | 2002 |
Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy.
Topics: Administration, Topical; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antibodies; Benzothiazoles; Brain; Disease Models, Animal; Fluorescent Dyes; Humans; Immunoglobulin Fab Fragments; Immunoglobulin Fc Fragments; Immunotherapy; Mice; Mice, Transgenic; Microscopy, Fluorescence; Mutation; Phagocytosis; Plaque, Amyloid; Thiazoles | 2002 |
Aggregation and self-assembly of hydrophobins from Trichoderma reesei: low-resolution structural models.
Topics: Benzothiazoles; Biophysical Phenomena; Biophysics; Fungal Proteins; Models, Molecular; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Scattering, Radiation; Thiazoles; Trichoderma; Water; X-Rays | 2002 |
Amyloid architecture: complementary assembly of heterogeneous combinations of three or four peptides into amyloid fibrils.
Topics: Amino Acid Sequence; Amyloid; Benzothiazoles; Circular Dichroism; Hydrophobic and Hydrophilic Interactions; Microscopy, Electron; Models, Chemical; Molecular Sequence Data; Peptide Library; Peptides; Protein Binding; Protein Structure, Secondary; Spectrometry, Fluorescence; Static Electricity; Thiazoles | 2002 |
Oxidation-induced misfolding and aggregation of superoxide dismutase and its implications for amyotrophic lateral sclerosis.
Topics: Amino Acids; Amyotrophic Lateral Sclerosis; Benzothiazoles; Binding Sites; Chromatography, Liquid; Circular Dichroism; Erythrocytes; Humans; Hydrogen-Ion Concentration; Light; Microscopy, Atomic Force; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Neurons; Oxygen; Protein Binding; Protein Folding; Scattering, Radiation; Superoxide Dismutase; Thiazoles; Zinc | 2002 |
Beta-amyloid plaques in a model for sporadic Alzheimer's disease based on transgenic anti-nerve growth factor antibodies.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Autoantibodies; Benzothiazoles; Brain; Cerebellum; Disease Models, Animal; Locus Coeruleus; Mice; Mice, Transgenic; Neostriatum; Nerve Growth Factor; Neurofibrillary Tangles; Neurons; Plaque, Amyloid; Signal Transduction; Silver Staining; Thiazoles | 2002 |
Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Disease Models, Animal; Female; Humans; Male; Membrane Proteins; Mice; Mice, Transgenic; Neurotoxins; Plaque, Amyloid; Presenilin-1; Thiazoles | 2002 |
BIGH3 (TGFBI) Arg124 mutations influence the amyloid conversion of related peptides in vitro.
Topics: Amino Acid Sequence; Amino Acid Substitution; Amyloid; Benzothiazoles; Corneal Dystrophies, Hereditary; Deuterium Oxide; Extracellular Matrix Proteins; Fluorescent Dyes; Hydrogen Bonding; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Neoplasm Proteins; Peptide Fragments; Protein Structure, Secondary; Sequence Deletion; Spectroscopy, Fourier Transform Infrared; Structure-Activity Relationship; Thiazoles; Transforming Growth Factor beta | 2002 |
Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein.
Topics: Amino Acid Substitution; Animals; Apoptosis; Benzothiazoles; Brain; Brain Chemistry; Cell Count; Disease Models, Animal; Homozygote; Humans; Immunohistochemistry; Mice; Mice, Transgenic; Motor Neurons; Neurodegenerative Diseases; Paraparesis; Phenotype; Phosphorylation; Sarcosine; Solubility; Spinal Cord; tau Proteins; Thiazoles | 2002 |
Amyloid fibril formation by a synthetic peptide from a region of human acetylcholinesterase that is homologous to the Alzheimer's amyloid-beta peptide.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Biotinylation; Cell Division; Circular Dichroism; Coloring Agents; Congo Red; Fluorescent Dyes; Humans; Microscopy, Electron; Neurofibrillary Tangles; PC12 Cells; Peptide Fragments; Protein Binding; Rats; Thiazoles | 2002 |
Molecular imaging of amyloid beta peptides in mouse brain sections using mass spectrometry.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Neuropathies, Familial; Animals; Benzothiazoles; Blotting, Western; Brain; Brain Chemistry; Frozen Sections; Humans; Image Processing, Computer-Assisted; Mice; Mice, Transgenic; Molecular Sequence Data; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiazoles; Tissue Distribution | 2002 |
IMPY: an improved thioflavin-T derivative for in vivo labeling of beta-amyloid plaques.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Autopsy; Autoradiography; Benzothiazoles; Fluorescence; Humans; Mice; Mice, Transgenic; Molecular Probes; Plaque, Amyloid; Pyridines; Thiazoles | 2002 |
The ceruloplasmin and hydrogen peroxide system induces alpha-synuclein aggregation in vitro.
Topics: alpha-Synuclein; Benzothiazoles; Ceruloplasmin; Humans; Hydrogen Peroxide; Hydroxyl Radical; Immunoblotting; Microscopy, Electron; Nerve Tissue Proteins; Protein Folding; Spectrometry, Fluorescence; Staining and Labeling; Synucleins; Thiazoles | 2002 |
Acid Denaturation of alpha1-antitrypsin: characterization of a novel mechanism of serpin polymerization.
Topics: Acids; alpha 1-Antitrypsin; Benzothiazoles; Biopolymers; Buffers; Circular Dichroism; Humans; Hydrogen-Ion Concentration; Kinetics; Protein Conformation; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Serpins; Spectrometry, Fluorescence; Structure-Activity Relationship; Thiazoles; Tryptophan | 2002 |
Molecular targeting of Alzheimer's amyloid plaques for contrast-enhanced magnetic resonance imaging.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Binding, Competitive; Blood-Brain Barrier; Brain; Contrast Media; Disease Models, Animal; Gadolinium; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Membrane Proteins; Mice; Mice, Transgenic; Molecular Probe Techniques; Neurons; Peptide Fragments; Plaque, Amyloid; Predictive Value of Tests; Presenilin-1; Putrescine; Reproducibility of Results; Thiazoles | 2002 |
Probing the role of backbone hydrogen bonding in beta-amyloid fibrils with inhibitor peptides containing ester bonds at alternate positions.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Benzothiazoles; Congo Red; Cross-Linking Reagents; Diphenylhexatriene; Esters; Fluorescent Dyes; Humans; Hydrogen Bonding; Molecular Sequence Data; Peptide Fragments; Phenylalanine; Protein Binding; Protein Conformation; Spectrometry, Fluorescence; Spectrometry, Mass, Electrospray Ionization; Thiazoles; Ultracentrifugation | 2003 |
X-ray absorption spectroscopy reveals a substantial increase of sulfur oxidation in transthyretin (TTR) upon fibrillization.
Topics: Benzothiazoles; Electron Probe Microanalysis; Models, Molecular; Oxidation-Reduction; Prealbumin; Protein Binding; Protein Conformation; Sulfur; Thiazoles; X-Ray Diffraction | 2003 |
Electron microscopic analysis of nanoparticles delivering thioflavin-T after intrahippocampal injection in mouse: implications for targeting beta-amyloid in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Drug Carriers; Drug Delivery Systems; Enbucrilate; Female; Fluorescent Dyes; Hippocampus; Injections; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron; Nanotechnology; Particle Size; Polymers; Polystyrenes; Thiazoles | 2003 |
In vivo multiphoton imaging of a transgenic mouse model of Alzheimer disease reveals marked thioflavine-S-associated alterations in neurite trajectories.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Axons; Benzothiazoles; Cerebral Cortex; Dendrites; Dextrans; Disease Models, Animal; Fluorescent Dyes; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Fluorescence, Multiphoton; Neurites; Neuropil; Plaque, Amyloid; Thiazoles | 2003 |
Amyloid-like fibril formation in an all beta-barrel protein. Partially structured intermediate state(s) is a precursor for fibril formation.
Topics: Amyloid beta-Peptides; Anilino Naphthalenesulfonates; Animals; Benzothiazoles; Circular Dichroism; Congo Red; Fibroblast Growth Factor 1; Fluorescent Dyes; Isotopes; Magnetic Resonance Spectroscopy; Microscopy, Electron; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Recombinant Proteins; Salamandridae; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Thiazoles; Time Factors; Ultraviolet Rays; X-Ray Diffraction | 2003 |
Mutations in the B1 domain of protein G that delay the onset of amyloid fibril formation in vitro.
Topics: Amyloid; Bacterial Proteins; Benzothiazoles; Fluorescence; Humans; In Vitro Techniques; Magnetic Resonance Spectroscopy; Mass Spectrometry; Microscopy, Electron; Mutation; Streptococcus; Thiazoles | 2003 |
Conformational behavior and aggregation of alpha-synuclein in organic solvents: modeling the effects of membranes.
Topics: Alcohols; alpha-Synuclein; Benzothiazoles; Circular Dichroism; Ethanol; Fluorescent Dyes; Humans; Kinetics; Light; Models, Chemical; Nerve Tissue Proteins; Phospholipids; Propanols; Protein Conformation; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Scattering, Radiation; Solvents; Spectroscopy, Fourier Transform Infrared; Synucleins; Thiazoles; Trifluoroethanol | 2003 |
Conformational restriction via cyclization in beta-amyloid peptide Abeta(1-28) leads to an inhibitor of Abeta(1-28) amyloidogenesis and cytotoxicity.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Benzothiazoles; Cell Survival; Chromatography, Gel; Circular Dichroism; Congo Red; Cyclization; Drug Design; Electrophoresis, Polyacrylamide Gel; Humans; Microscopy, Electron; Molecular Sequence Data; Peptide Fragments; Protein Binding; Protein Conformation; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared; Structure-Activity Relationship; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 2003 |
Reversible amyloid formation by the p53 tetramerization domain and a cancer-associated mutant.
Topics: Amyloid; Benzothiazoles; Circular Dichroism; Coloring Agents; Congo Red; Dose-Response Relationship, Drug; Guanidine; Hot Temperature; Humans; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Microscopy, Electron; Mutation; Neoplasms; Protein Binding; Protein Conformation; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Spectrophotometry; Spectroscopy, Fourier Transform Infrared; Temperature; Thiazoles; Time Factors; Tumor Suppressor Protein p53 | 2003 |
Direct observation of amyloid fibril growth monitored by thioflavin T fluorescence.
Topics: Amyloid beta-Peptides; Benzothiazoles; Fluorescent Dyes; Humans; Microscopy, Fluorescence; Plaque, Amyloid; Thiazoles | 2003 |
In vivo imaging of reactive oxygen species specifically associated with thioflavine S-positive amyloid plaques by multiphoton microscopy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antioxidants; Benzothiazoles; Cerebral Cortex; Cyclic N-Oxides; Disease Models, Animal; Fluorescent Dyes; Free Radical Scavengers; Free Radicals; Infrared Rays; Lasers; Mice; Mice, Transgenic; Microscopy, Fluorescence, Multiphoton; Nitrogen Oxides; Oxidation-Reduction; Oxidative Stress; Plaque, Amyloid; Reactive Oxygen Species; Thiazoles | 2003 |
Direct determination of the proportion of intra- and extra-cellular neocortical neurofibrillary tangles in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Fluorescent Antibody Technique; Humans; Inclusion Bodies; Microtubule-Associated Proteins; Neocortex; Neurofibrillary Tangles; Neurons; Plaque, Amyloid; tau Proteins; Thiazoles | 2003 |
Specific compositions of amyloid-beta peptides as the determinant of toxic beta-aggregation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Cell Line; Dimerization; Genetic Variation; Humans; Hydrophobic and Hydrophilic Interactions; Kinetics; Peptide Fragments; Static Electricity; Thiazoles | 2003 |
Unmasking tandem site interaction in human acetylcholinesterase. Substrate activation with a cationic acetanilide substrate.
Topics: Acetanilides; Acetophenones; Acetylcholinesterase; Acetylthiocholine; Acylation; Benzothiazoles; Binding Sites; Catalysis; Cholinesterase Inhibitors; Drug Interactions; Fluorescent Dyes; Humans; Hydrolysis; Ligands; Models, Chemical; Mutagenesis, Site-Directed; Propidium; Protein Conformation; Recombinant Proteins; Stereoisomerism; Substrate Specificity; Thiazoles | 2003 |
Intracranially administered anti-Abeta antibodies reduce beta-amyloid deposition by mechanisms both independent of and associated with microglial activation.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antibodies; Benzothiazoles; Drug Administration Routes; Frontal Lobe; Hippocampus; Histocompatibility Antigens Class II; Immunization, Passive; Immunohistochemistry; Leukocyte Common Antigens; Membrane Proteins; Mice; Mice, Transgenic; Microglia; Plaque, Amyloid; Presenilin-1; Thiazoles; Time Factors | 2003 |
Structural transformations of oligomeric intermediates in the fibrillation of the immunoglobulin light chain LEN.
Topics: Amyloid; Amyloidosis; Anilino Naphthalenesulfonates; Benzothiazoles; Circular Dichroism; Electrophoresis, Polyacrylamide Gel; Fluorescence Polarization; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Immunoglobulin Light Chains; Multiple Myeloma; Protein Conformation; Protein Denaturation; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Thiazoles; Tryptophan | 2003 |
Amyloid protofilaments from the calcium-binding protein equine lysozyme: formation of ring and linear structures depends on pH and metal ion concentration.
Topics: Amyloid; Animals; Benzothiazoles; Blotting, Western; Calcium; Coloring Agents; Congo Red; Crystallography, X-Ray; Electrophoresis, Polyacrylamide Gel; Horses; Hydrogen-Ion Concentration; Hydrolysis; Ions; Microscopy, Atomic Force; Models, Molecular; Muramidase; Protein Conformation; Protein Structure, Tertiary; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Temperature; Thiazoles | 2003 |
A systematic investigation into the effect of protein destabilisation on beta 2-microglobulin amyloid formation.
Topics: Amyloid; Benzothiazoles; beta 2-Microglobulin; Circular Dichroism; Coloring Agents; Congo Red; Dose-Response Relationship, Drug; Escherichia coli; Humans; Hydrogen-Ion Concentration; Microscopy, Electron; Models, Molecular; Mutagenesis, Site-Directed; Point Mutation; Protein Denaturation; Sodium Chloride; Thiazoles; Time Factors; Ultraviolet Rays; Urea; X-Ray Diffraction | 2003 |
A peptide motif consisting of glycine, alanine, and valine is required for the fibrillization and cytotoxicity of human alpha-synuclein.
Topics: Alanine; alpha-Synuclein; Amino Acid Motifs; Benzothiazoles; Circular Dichroism; Escherichia coli; Glycine; Humans; Microscopy, Atomic Force; Mutagenesis, Site-Directed; Mutation; Nerve Tissue Proteins; Peptides; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Proteins; Synucleins; Thiazoles; Time Factors; Valine | 2003 |
Hydrogen exchange-mass spectrometry analysis of beta-amyloid peptide structure.
Topics: Amyloid beta-Peptides; Benzothiazoles; Congo Red; Fluorescence; Humans; Hydrogen; Hydrophobic and Hydrophilic Interactions; Peptide Fragments; Protein Structure, Tertiary; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiazoles | 2003 |
Glycation induces formation of amyloid cross-beta structure in albumin.
Topics: Amyloid; Animals; Benzothiazoles; Cell Death; Cell Line; Congo Red; Dimerization; Glycation End Products, Advanced; Glycosylation; Mice; Microscopy, Electron; Protein Denaturation; Protein Folding; Protein Structure, Quaternary; Protein Structure, Secondary; Serum Albumin; Thiazoles; Tissue Plasminogen Activator | 2003 |
An amyloid-like C-terminal domain of thrombospondin-1 displays CD47 agonist activity requiring both VVM motifs.
Topics: Amino Acid Motifs; Amino Acid Sequence; Amyloid; Antigens, CD; Benzothiazoles; Carrier Proteins; CD47 Antigen; Cell Adhesion; Circular Dichroism; GTP-Binding Proteins; Guanidine; Heparin; Humans; Melanoma; Models, Biological; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Peptide Fragments; Pertussis Toxin; Protein Binding; Protein Conformation; Protein Denaturation; Protein Structure, Tertiary; Signal Transduction; Thiazoles; Thrombospondin 1; Tumor Cells, Cultured; Vitronectin | 2003 |
Nitration of tau protein is linked to neurodegeneration in tauopathies.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Basal Ganglia; Benzothiazoles; Cell Line; Cerebral Cortex; Down Syndrome; Female; Fluorescent Dyes; Humans; Male; Middle Aged; Nerve Degeneration; Neurodegenerative Diseases; Neurofibrillary Tangles; Nitrates; Pick Disease of the Brain; tau Proteins; Tauopathies; Thiazoles; Tissue Distribution | 2003 |
Analysis of yeast prion aggregates with amyloid-staining compound in vivo.
Topics: Amyloid; Benzothiazoles; Fluorescent Dyes; Fungal Proteins; Immunohistochemistry; Peptide Termination Factors; Prions; Protein Conformation; Saccharomyces cerevisiae Proteins; Thiazoles | 2003 |
Environmental influences on bovine kappa-casein: reduction and conversion to fibrillar (amyloid) structures.
Topics: Amyloid; Animals; Benzothiazoles; Biopolymers; Caseins; Cattle; Circular Dichroism; Colloids; Female; Fluorescent Dyes; Humans; Mammary Glands, Animal; Models, Molecular; Molecular Weight; Oxidation-Reduction; Potassium Chloride; Protein Conformation; Spectroscopy, Fourier Transform Infrared; Temperature; Thiazoles; Titrimetry; Ultracentrifugation | 2003 |
Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: implications for the prevention and therapeutics of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Flavonoids; Humans; Kidney; Kinetics; Microscopy, Electron; Peptide Fragments; Phenols; Polymers; Quercetin; Spectrometry, Fluorescence; Tetrazolium Salts; Thiazoles | 2003 |
In vivo studies of the frog's liver during the excretion of thioflavine S and vasoflavine.
Topics: Animals; Anura; Benzothiazoles; Flavins; Liver; Microscopy; Ranidae; Thiazoles | 1954 |
FLUORESCENCE MICROSCOPY WITH THIOFLAVINE-T IN THE DIAGNOSIS OF AMYLOID.
Topics: Amyloid; Amyloidosis; Benzothiazoles; Coloring Agents; Congo Red; Diagnosis; Fluorescence; Fluorescent Dyes; Gentian Violet; Humans; Microscopy; Microscopy, Fluorescence; Staining and Labeling; Thiazoles | 1963 |
INCREASE OF THIOFLAVINE-T-STAINING MATERIAL (AMYLOID) IN HUMAN TISSUES WITH AGE.
Topics: Aging; Amyloid; Benzothiazoles; Cerebral Cortex; Fluorescent Dyes; Geriatrics; Histocytochemistry; Humans; Myocardium; Spleen; Staining and Labeling; Thiazoles | 1964 |
SCREENING FOR AMYLOID WITH THE THIOFLAVIN-T FLUORESCENT METHOD.
Topics: Amyloid; Amyloidosis; Benzothiazoles; Coloring Agents; Diagnosis; Fluorescent Dyes; Humans; Staining and Labeling; Thiazoles | 1965 |
[Analysis of dyes; fluorochrome mixture thioflavine S].
Topics: Benzothiazoles; Coloring Agents; Fluorescent Dyes; Thiazoles | 1955 |
The role of protein stability, solubility, and net charge in amyloid fibril formation.
Topics: Amyloid; Benzothiazoles; Circular Dichroism; Enzyme Stability; Hydrogen-Ion Concentration; Isoenzymes; Point Mutation; Protein Binding; Protein Conformation; Protein Denaturation; Protein Structure, Secondary; Ribonucleases; Solubility; Spectrometry, Fluorescence; Streptomyces aureofaciens; Thermodynamics; Thiazoles; Trifluoroethanol | 2003 |
Characterization of radioiodinated ligand binding to amyloid beta plaques.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Binding Sites; Binding, Competitive; Brain; Humans; Iodine Radioisotopes; Ligands; Male; Mice; Mice, Inbred ICR; Peptide Fragments; Plaque, Amyloid; Pyrazoles; Pyridines; Thiazoles; Tomography, Emission-Computed, Single-Photon | 2003 |
Partially folded intermediates in insulin fibrillation.
Topics: Acetic Acid; Acrylamide; Benzothiazoles; Chromatography, Gel; Circular Dichroism; Dimerization; Guanidine; Humans; Hydrogen-Ion Concentration; Insulin; Kinetics; Microscopy, Electron; Protein Conformation; Protein Denaturation; Protein Folding; Scattering, Radiation; Spectrometry, Fluorescence; Thiazoles; X-Rays | 2003 |
Proteasome inhibition stabilizes tau inclusions in oligodendroglial cells that occur after treatment with okadaic acid.
Topics: alpha-Crystallin B Chain; Benzothiazoles; Brain; Cell Line; Cysteine Endopeptidases; Cytoskeleton; Enzyme Inhibitors; Fluorescent Dyes; Humans; Immunohistochemistry; Inclusion Bodies; Leupeptins; Microtubules; Multienzyme Complexes; Okadaic Acid; Oligodendroglia; Phosphoprotein Phosphatases; Phosphorylation; Proteasome Endopeptidase Complex; Protein Phosphatase 2; tau Proteins; Tauopathies; Thiazoles | 2003 |
Amyloid nucleation and hierarchical assembly of Ure2p fibrils. Role of asparagine/glutamine repeat and nonrepeat regions of the prion domains.
Topics: Amino Acid Motifs; Amino Acid Sequence; Amyloid; Asparagine; Benzothiazoles; Dimerization; Glutamine; Glutathione Peroxidase; Hydrogen-Ion Concentration; Kinetics; Microscopy, Atomic Force; Molecular Sequence Data; Mutation; Prions; Protein Binding; Protein Structure, Tertiary; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Thiazoles; Time Factors | 2004 |
Amyloid fibril formation by lens crystallin proteins and its implications for cataract formation.
Topics: Aging; alpha-Crystallins; Amyloid; Animals; Benzothiazoles; beta-Crystallins; Cataract; Cattle; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; gamma-Crystallins; Guanidine; Hydrogen-Ion Concentration; Lens, Crystalline; Microscopy, Electron; Protein Folding; Protein Processing, Post-Translational; Temperature; Thiazoles; X-Ray Diffraction | 2004 |
The human amyloid-beta precursor protein770 mutation V717F generates peptides longer than amyloid-beta-(40-42) and flocculent amyloid aggregates.
Topics: Amino Acids; Amyloid; Amyloid beta-Peptides; Animals; Benzothiazoles; Cerebral Cortex; Chromatography, High Pressure Liquid; Cyanogen Bromide; Humans; Hydrolysis; Immunoblotting; Mass Spectrometry; Mice; Mice, Transgenic; Mutation; Peptides; Protein Structure, Tertiary; Sodium Dodecyl Sulfate; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiazoles; Time Factors | 2004 |
Neuronal fibrillogenesis: amyloid fibrils from primary neuronal cultures impair long-term memory in the crab Chasmagnathus.
Topics: Amyloid beta-Peptides; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Benzothiazoles; Brachyura; Cells, Cultured; Cerebellum; Culture Media, Conditioned; Dose-Response Relationship, Drug; Fluorometry; Immunohistochemistry; Male; Memory; Microscopy, Electron; Neurons; Peptide Fragments; Potassium Chloride; Rats; Rats, Wistar; Thiazoles; Time Factors | 2003 |
In vivo labeling of amyloid with BF-108.
Topics: Acridines; Affinity Labels; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Animals; Benzothiazoles; Brain; Female; Fluorescent Dyes; Humans; In Vitro Techniques; Male; Mice; Mice, Transgenic; Microscopy, Fluorescence; Neurofibrillary Tangles; Plaque, Amyloid; Rats; Rats, Wistar; Thiazoles | 2004 |
Effect of different anti-Abeta antibodies on Abeta fibrillogenesis as assessed by atomic force microscopy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antibodies; Benzothiazoles; Fluorescence; Microscopy, Atomic Force; Neurofibrillary Tangles; Peptide Fragments; Plaque, Amyloid; Protein Structure, Quaternary; Software; Thiazoles | 2004 |
Fibrillogenesis and cytotoxic activity of the amyloid-forming apomyoglobin mutant W7FW14F.
Topics: Anilino Naphthalenesulfonates; Animals; Apoproteins; Benzothiazoles; Cell Membrane; Cell Nucleus; Circular Dichroism; Coloring Agents; Cytoskeleton; Fluorescent Dyes; Hydrogen-Ion Concentration; Kinetics; Mice; Microscopy, Electron; Mutation; Myoglobin; NIH 3T3 Cells; Phalloidine; Propidium; Protein Structure, Secondary; Spectrometry, Fluorescence; Tetrazolium Salts; Thiazoles; Time Factors; Ultraviolet Rays | 2004 |
Neuroprotection against Abeta and glutamate toxicity by melatonin: are GABA receptors involved?
Topics: Amyloid beta-Peptides; Animals; Antioxidants; Benzothiazoles; Chick Embryo; Excitatory Amino Acid Antagonists; Fluorescent Dyes; GABA Antagonists; Glutamic Acid; Light; Melatonin; Neurons; Peptide Fragments; Picrotoxin; Receptors, GABA; Retina; Scattering, Radiation; Thiazoles | 2003 |
Neuronal localization of C1q in preclinical Alzheimer's disease.
Topics: Adult; Aged; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Biomarkers; Brain; Cerebral Cortex; Complement C1q; Disease Progression; Down Syndrome; Encephalitis; Female; Genetic Predisposition to Disease; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Humans; Immunohistochemistry; Middle Aged; Neurons; Peptide Fragments; Plaque, Amyloid; Thiazoles | 2004 |
Seeding specificity in amyloid growth induced by heterologous fibrils.
Topics: Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Biotinylation; Cell Division; Chromatography, High Pressure Liquid; Coloring Agents; Congo Red; Humans; Islet Amyloid Polypeptide; Kinetics; Microscopy, Electron; Molecular Sequence Data; Peptides; Point Mutation; Polymers; Protein Structure, Tertiary; Thiazoles; Time Factors | 2004 |
Evidence for an intermediate in tau filament formation.
Topics: Alzheimer Disease; Anions; Arachidonic Acid; Benzothiazoles; Humans; Hydrophobic and Hydrophilic Interactions; Intermediate Filament Proteins; Micelles; Microspheres; Neurofibrillary Tangles; Neurofilament Proteins; Recombinant Proteins; Spectrometry, Fluorescence; Static Electricity; Surface Properties; Surface-Active Agents; tau Proteins; Thiazoles | 2004 |
A purified fraction of thioflavine-S (vasoflavine); valuable agent for visualization of blood vessels.
Topics: Benzothiazoles; Blood Vessels; Coloring Agents; Humans; Thiazoles | 1951 |
An engineered PrPsc-like molecule from the chimera of mammalian prion protein and yeast Ure2p prion-inducing domain.
Topics: Amyloid; Animals; Benzothiazoles; Cattle; Circular Dichroism; Coloring Agents; Congo Red; Electrophoresis, Polyacrylamide Gel; Endopeptidase K; Microscopy; Microscopy, Electron; Plasmids; Prions; Protein Conformation; Protein Engineering; Protein Isoforms; Protein Structure, Secondary; Protein Structure, Tertiary; PrPSc Proteins; Recombinant Fusion Proteins; Recombinant Proteins; Saccharomyces cerevisiae; Spectrometry, Fluorescence; Thiazoles | 2004 |
Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor.
Topics: Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; DNA, Complementary; Enzyme-Linked Immunosorbent Assay; Genetic Vectors; Humans; Immunoblotting; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microcirculation; Models, Genetic; Mutation; Peptides; Promoter Regions, Genetic; Thiazoles; Time Factors; Tissue Distribution; Transgenes | 2004 |
Curcumin has potent anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Anti-Inflammatory Agents, Non-Steroidal; Benzothiazoles; Cinnamates; Curcumin; Depsides; Dose-Response Relationship, Drug; In Vitro Techniques; Kinetics; Lipoxygenase Inhibitors; Masoprocol; Microscopy, Electron; Microscopy, Polarization; Neurofibrillary Tangles; Peptide Fragments; Platelet Aggregation Inhibitors; Rosmarinic Acid; Spectrometry, Fluorescence; Thiazoles; Time Factors | 2004 |
Inhibiting aggregation of alpha-synuclein with human single chain antibody fragments.
Topics: alpha-Synuclein; Amino Acid Sequence; Benzothiazoles; Binding Sites, Antibody; Epitope Mapping; Fluorescent Dyes; Humans; Immunoglobulin Variable Region; Inovirus; Kinetics; Microscopy, Atomic Force; Molecular Sequence Data; Nerve Tissue Proteins; Peptide Library; Protein Structure, Tertiary; Recombinant Proteins; Solubility; Synucleins; Thiazoles | 2004 |
Pseudophosphorylation of tau protein alters its ability for self-aggregation.
Topics: Amino Acid Substitution; Animals; Benzothiazoles; Heparin; Macromolecular Substances; Metals; Mice; Microtubules; Mutagenesis, Site-Directed; Phosphorylation; Protein Binding; Protein Conformation; tau Proteins; Thiazoles | 2004 |
The HPV16 E7 viral oncoprotein self-assembles into defined spherical oligomers.
Topics: Benzothiazoles; Casein Kinase II; Circular Dichroism; Congo Red; Dimerization; Fluorescent Dyes; Humans; Molecular Weight; Oncogene Proteins, Viral; Papillomaviridae; Papillomavirus E7 Proteins; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Protein Structure, Secondary; Solubility; Thiazoles; Virus Assembly; Zinc | 2004 |
Annular oligomeric amyloid intermediates observed by in situ atomic force microscopy.
Topics: Aluminum Silicates; Amyloid; Benzothiazoles; Hydrogen-Ion Concentration; Ions; Kinetics; Microscopy, Atomic Force; Protein Structure, Tertiary; Sodium Chloride; Temperature; Thermodynamics; Thiazoles; Time Factors | 2004 |
Molecular basis of barriers for interspecies transmissibility of mammalian prions.
Topics: Amino Acid Sequence; Amino Acid Substitution; Amyloid; Animals; Animals, Genetically Modified; Benzothiazoles; Cattle; Disease Transmission, Infectious; Fluorescent Dyes; Humans; Molecular Sequence Data; Prion Diseases; Prions; Protein Conformation; Recombinant Proteins; Sequence Alignment; Species Specificity; Thiazoles | 2004 |
The flavonoid baicalein inhibits fibrillation of alpha-synuclein and disaggregates existing fibrils.
Topics: alpha-Synuclein; Anaerobiosis; Benzothiazoles; Circular Dichroism; Escherichia coli; Flavanones; Flavonoids; Humans; Light; Lysine; Microscopy, Atomic Force; Molecular Weight; Nerve Tissue Proteins; Oxidation-Reduction; Protein Conformation; Quinones; Scattering, Radiation; Solubility; Spectrometry, Fluorescence; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Synucleins; Thiazoles; Tyrosine | 2004 |
Proteins can convert to beta-sheet in single crystals.
Topics: Benzothiazoles; Carboxyl and Carbamoyl Transferases; Crystallization; Insulin; Protein Structure, Secondary; Protein Subunits; Spectrum Analysis, Raman; Thiazoles | 2004 |
NMR of alpha-synuclein-polyamine complexes elucidates the mechanism and kinetics of induced aggregation.
Topics: alpha-Synuclein; Amino Acid Sequence; Benzothiazoles; Binding Sites; Fluorescent Dyes; Humans; Molecular Sequence Data; Molecular Structure; Nerve Tissue Proteins; Nuclear Magnetic Resonance, Biomolecular; Parkinson Disease; Polyamines; Protein Structure, Secondary; Synucleins; Thiazoles | 2004 |
Differential expression of cholesterol hydroxylases in Alzheimer's disease.
Topics: Adenoviridae; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Astrocytes; Benzothiazoles; Brain; Cells, Cultured; Cerebral Cortex; Cholestanetriol 26-Monooxygenase; Cholesterol 24-Hydroxylase; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Humans; Hydroxycholesterols; Immunoblotting; Immunohistochemistry; Inhibitory Concentration 50; Liver X Receptors; Neurons; Oligodendroglia; Orphan Nuclear Receptors; Polymorphism, Genetic; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Signal Transduction; Steroid Hydroxylases; Thiazoles; Time Factors | 2004 |
A seed for Alzheimer amyloid in the brain.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Antibody Specificity; Benzothiazoles; Brain; Brain Chemistry; Cell Survival; Cells, Cultured; G(M1) Ganglioside; Humans; Liposomes; Macaca fascicularis; Macromolecular Substances; Microscopy, Immunoelectron; Middle Aged; Neurons; Peptide Fragments; Rats; Rats, Sprague-Dawley; Thiazoles; Time Factors | 2004 |
Single chain variable fragments against beta-amyloid (Abeta) can inhibit Abeta aggregation and prevent abeta-induced neurotoxicity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Humans; Immunoglobulin Variable Region; Microscopy, Atomic Force; Neuroblastoma; Neurons; Peptide Library; Plaque, Amyloid; Surface Plasmon Resonance; Thiazoles; Tumor Cells, Cultured | 2004 |
Cholinergic nucleus basalis tauopathy emerges early in the aging-MCI-AD continuum.
Topics: Acetylcholine; Acetyltransferases; Aged; Aged, 80 and over; Alzheimer Disease; Basal Nucleus of Meynert; Benzothiazoles; Case-Control Studies; Cognition Disorders; Cohort Studies; Female; Histological Techniques; Humans; Immunohistochemistry; Longitudinal Studies; Male; Neurofibrillary Tangles; Neuropsychological Tests; Postmortem Changes; tau Proteins; Thiazoles | 2004 |
Transthyretin aggregation under partially denaturing conditions is a downhill polymerization.
Topics: Benzothiazoles; Biopolymers; Chromatography, Gel; Hydrogen-Ion Concentration; Kinetics; Microscopy, Atomic Force; Microscopy, Electron; Prealbumin; Protein Denaturation; Protein Structure, Quaternary; Spectrometry, Fluorescence; Thiazoles | 2004 |
Inflammation occurs early during the Abeta deposition process in TgCRND8 mice.
Topics: Age Factors; Alzheimer Disease; Amygdala; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Brain; CD11b Antigen; Disease Models, Animal; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; Inflammation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Neocortex; Plaque, Amyloid; Thiazoles | 2004 |
Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antibodies, Monoclonal; Benzothiazoles; Down Syndrome; Female; Fluorescent Antibody Technique, Indirect; Humans; Immunohistochemistry; Male; Membrane Proteins; Mice; Mice, Transgenic; Middle Aged; Neocortex; Neurons; Non-Fibrillar Collagens; Peptide Fragments; Plaque, Amyloid; Thiazoles; Tissue Distribution | 2004 |
The human serpin proteinase inhibitor-9 self-associates at physiological temperatures.
Topics: Benzothiazoles; Dementia; Emphysema; Humans; Microscopy, Electron; Multiprotein Complexes; Protein Denaturation; Protein Folding; Protein Structure, Tertiary; Serpins; Spectrometry, Fluorescence; Structure-Activity Relationship; Thiazoles; Thrombosis | 2004 |
Amyloid fibril formation by a partially structured intermediate state of alpha-chymotrypsin.
Topics: Amyloid; Benzothiazoles; Chymotrypsin; Circular Dichroism; Congo Red; Fluorescent Dyes; Protein Structure, Secondary; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Thiazoles; Trifluoroethanol | 2004 |
Cholesterol, copper, and accumulation of thioflavine S-reactive Alzheimer's-like amyloid beta in rabbit brain.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Blood Vessels; Brain; Cholesterol; Copper; Disease Models, Animal; Drug Synergism; Food, Formulated; Immunohistochemistry; Male; Metabolic Clearance Rate; Neurons; Rabbits; Thiazoles; Up-Regulation | 2004 |
alpha-synuclein is required for the fibrillar nature of ubiquitinated inclusions induced by proteasomal inhibition in primary neurons.
Topics: Acetylcysteine; alpha-Synuclein; Animals; Apoptosis; Benzothiazoles; Blotting, Western; Cells, Cultured; Cytoplasm; Genotype; Lewy Bodies; Mice; Mice, Knockout; Microscopy, Fluorescence; Nerve Tissue Proteins; Neurons; Protease Inhibitors; Proteasome Inhibitors; Rats; Synucleins; Thiazoles; Time Factors; Ubiquitin | 2004 |
Nordihydroguaiaretic acid does not disaggregate beta-amyloid(1-40) protofibrils but does inhibit growth arising from direct protofibril association.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Benzothiazoles; Fluorescence; Humans; Masoprocol; Peptide Fragments; Thiazoles | 2004 |
Morphological characterization of Thioflavin-S-positive amyloid plaques in transgenic Alzheimer mice and effect of passive Abeta immunotherapy on their clearance.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Disease Models, Animal; Fluorescent Dyes; Heterozygote; Humans; Immunization, Passive; Immunotherapy; Metabolic Clearance Rate; Mice; Mice, Transgenic; Neurites; Neurofibrillary Tangles; Plaque, Amyloid; Thiazoles | 2004 |
Targeting the neurotoxic species in Alzheimer's disease: inhibitors of Abeta oligomerization.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Survival; Cells, Cultured; Hippocampus; Inhibitory Concentration 50; Neurons; Neuroprotective Agents; Plaque, Amyloid; Protein Structure, Quaternary; Rats; Solubility; Thiazoles | 2004 |
Vitamin A exhibits potent antiamyloidogenic and fibril-destabilizing effects in vitro.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Benzothiazoles; beta Carotene; Cell Line; Dose-Response Relationship, Drug; Humans; Kinetics; Microscopy, Electron; Molecular Structure; Neurofibrils; Retinaldehyde; Thiazoles; Tretinoin; Vitamin A; Vitamins | 2004 |
Mechanism of prion propagation: amyloid growth occurs by monomer addition.
Topics: Amyloid; Benzothiazoles; Cell Proliferation; Computational Biology; Computer Simulation; Fungal Proteins; Kinetics; Microscopy, Atomic Force; Microscopy, Fluorescence; Models, Statistical; Molecular Sequence Data; Peptide Termination Factors; Peptides; Polymers; Prions; Saccharomyces cerevisiae Proteins; Thiazoles; Time Factors; Ultracentrifugation | 2004 |
Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases.
Topics: Amyloid; Amyloid beta-Peptides; Benzothiazoles; Cell Membrane; Chromatography; Electrophysiology; Humans; Ions; Lipid Bilayers; Microscopy, Electron; Neurodegenerative Diseases; Peptides; Protein Conformation; Protein Folding; Spectrometry, Fluorescence; Thiazoles; Time Factors; Transfection | 2004 |
An in vitro screening assay based on synthetic prion protein peptides for identification of fibril-interfering compounds.
Topics: Amino Acid Sequence; Benzothiazoles; Drug Evaluation, Preclinical; Fluorescent Dyes; Gelatin; Humans; Models, Molecular; Molecular Sequence Data; Neurodegenerative Diseases; Neurofibrils; Peptide Fragments; Prions; Reproducibility of Results; Sensitivity and Specificity; Staining and Labeling; Tetracycline; Thiazoles; Time Factors | 2004 |
Unraveling the amyloid associated with human medullary thyroid carcinoma.
Topics: Amyloid; Amyloidosis; Benzothiazoles; Calcitonin; Carcinoma, Medullary; Electrophoresis, Polyacrylamide Gel; Fluorescent Dyes; Humans; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Protein Denaturation; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiazoles; Thyroid Neoplasms | 2004 |
Anionic contribution for fibrous maturation of protofibrillar assemblies of the human tau repeat domain in a fluoroalcohol solution.
Topics: Adult; Anions; Benzothiazoles; Binding Sites; Dose-Response Relationship, Drug; Humans; Kinetics; Light; Micelles; Nanotechnology; Nerve Tissue Proteins; Propanols; Protein Processing, Post-Translational; Protein Structure, Secondary; Protein Structure, Tertiary; Repetitive Sequences, Amino Acid; Scattering, Radiation; Solutions; tau Proteins; Thermodynamics; Thiazoles | 2004 |
Glycogen synthase kinase 3 beta induces caspase-cleaved tau aggregation in situ.
Topics: Animals; Benzothiazoles; Caspase 3; Caspases; Cell Death; CHO Cells; Cricetinae; Cytoskeleton; Enzyme Activation; Gene Expression; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Microtubules; Peptide Fragments; Phosphorylation; tau Proteins; Thiazoles; Transfection | 2004 |
Apolipoprotein is required for the formation of filamentous amyloid, but not for amorphous Abeta deposition, in an AbetaPP/PS double transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Protein Precursor; Animals; Apolipoproteins E; Benzothiazoles; Cerebral Cortex; Disease Models, Animal; Intermediate Filament Proteins; Mice; Mice, Transgenic; Thiazoles | 2004 |
A designed protein interface that blocks fibril formation.
Topics: Amyloid; Bacterial Proteins; Benzothiazoles; Fluorescence; Mutagenesis, Site-Directed; Protein Engineering; Protein Structure, Tertiary; Thiazoles | 2004 |
Amyloid-beta protofibrils differ from amyloid-beta aggregates induced in dilute hexafluoroisopropanol in stability and morphology.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Biochemistry; Chromatography; Circular Dichroism; Humans; Ions; Kinetics; Light; Microscopy, Atomic Force; Microscopy, Electron; Peptide Fragments; Propanols; Protein Conformation; Scattering, Radiation; Thiazoles; Time Factors | 2005 |
An intersheet packing interaction in A beta fibrils mapped by disulfide cross-linking.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Antibodies, Monoclonal; Benzothiazoles; Cross-Linking Reagents; Cysteine; Disulfides; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxidation-Reduction; Peptide Fragments; Peptide Mapping; Protein Structure, Secondary; Spectrometry, Fluorescence; Thiazoles | 2004 |
Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoates; Benzothiazoles; Biphenyl Compounds; Blood-Brain Barrier; Brain; Cell Line, Tumor; Congo Red; Curcumin; Diamines; Humans; Ibuprofen; Mice; Mice, Transgenic; Naproxen; Peptide Fragments; Plaque, Amyloid; Protein Binding; Protein Denaturation; Protein Structure, Quaternary; Pyridazines; Solubility; Thiazoles | 2005 |
Investigating the effects of mutations on protein aggregation in the cell.
Topics: Animals; Benzothiazoles; Biotechnology; Blotting, Western; Chickens; Cloning, Molecular; Cytosol; DNA Mutational Analysis; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Macromolecular Substances; Muramidase; Mutation; Peptides; Point Mutation; Protein Binding; Protein Conformation; Protein Denaturation; Protein Engineering; Protein Folding; Protein Structure, Tertiary; Solubility; Thiazoles; Urea | 2005 |
CLAC binds to amyloid beta peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Benzothiazoles; Cell Line; Collagen; Culture Media, Conditioned; DNA; Dose-Response Relationship, Drug; Heparin; Humans; Immunoblotting; Microscopy, Electron; Models, Biological; Molecular Sequence Data; Mutation; Non-Fibrillar Collagens; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Sodium Chloride; Spectrometry, Fluorescence; Static Electricity; Temperature; Thiazoles; Time Factors; Transfection; Trypsin | 2005 |
Evidence for the presence of three distinct binding sites for the thioflavin T class of Alzheimer's disease PET imaging agents on beta-amyloid peptide fibrils.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Binding Sites; Binding, Competitive; Centrifugation, Density Gradient; Dose-Response Relationship, Drug; Fluorescence Resonance Energy Transfer; Humans; Kinetics; Ligands; Models, Biological; Models, Chemical; Peptide Fragments; Peptides; Positron-Emission Tomography; Protein Binding; Spectrometry, Fluorescence; Thiazoles | 2005 |
The binding of thioflavin-T to amyloid fibrils: localisation and implications.
Topics: Amyloid; Animals; Benzothiazoles; Binding Sites; Cattle; Fluorescent Dyes; Insulin; Lactoglobulins; Microscopy, Confocal; Particle Size; Protein Binding; Thiazoles | 2005 |
Inhibition of amyloid fibrillogenesis and toxicity by a peptide chaperone.
Topics: alpha-Crystallins; Alzheimer Disease; Amino Acid Sequence; Amino Acid Substitution; Amyloid beta-Peptides; Animals; Asparagine; Benzothiazoles; Cell Survival; Fluorescent Dyes; Humans; Molecular Chaperones; Molecular Sequence Data; PC12 Cells; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Thiazoles; Toxicity Tests | 2004 |
Heat shock protein 70 inhibits alpha-synuclein fibril formation via preferential binding to prefibrillar species.
Topics: alpha-Synuclein; Benzothiazoles; Chromatography, Gel; Circular Dichroism; Flow Cytometry; Genetic Vectors; HSP70 Heat-Shock Proteins; Humans; Lewy Bodies; Magnetic Resonance Spectroscopy; Microscopy, Electron; Microscopy, Fluorescence; Molecular Chaperones; Nerve Tissue Proteins; Protein Binding; Protein Folding; Protein Structure, Secondary; Subcellular Fractions; Synucleins; Thiazoles; Time Factors | 2005 |
Efficient radiosynthesis of carbon-11 labelled uncharged Thioflavin T derivatives using [11C]methyl triflate for beta-amyloid imaging in Alzheimer's Disease with PET.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Carbon Radioisotopes; Humans; Isotope Labeling; Mesylates; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2005 |
Single-site mutations in a hyperthermophilic variant of the B1 domain of protein G result in self-assembled oligomers.
Topics: Amino Acid Sequence; Amino Acid Substitution; Bacterial Proteins; Benzothiazoles; Chromatography, Gel; Circular Dichroism; Congo Red; Electrophoresis, Polyacrylamide Gel; Fluorescent Dyes; Genetic Variation; Hot Temperature; Immunoglobulin G; Light; Molecular Sequence Data; Mutagenesis, Insertional; Protein Processing, Post-Translational; Protein Structure, Tertiary; Scattering, Radiation; Spectrometry, Fluorescence; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiazoles | 2005 |
Role of amyloid type cross beta-structure in the formation of soluble aggregate and gel in heat-induced ovalbumin.
Topics: Amyloid; Benzothiazoles; Fluorescent Dyes; Gels; Hot Temperature; Hydrogen-Ion Concentration; Ovalbumin; Protein Denaturation; Protein Structure, Secondary; Spectrometry, Fluorescence; Thiazoles | 2005 |
Fibrillogenesis of apomyoglobin facilitated by aggregation sequence of yeast Sup35 in various regions.
Topics: Amino Acid Sequence; Animals; Apoproteins; Benzothiazoles; Hydrogen-Ion Concentration; Male; Microscopy, Electron; Models, Molecular; Molecular Sequence Data; Mutation; Myoglobin; Peptide Termination Factors; Prions; Protein Denaturation; Protein Structure, Tertiary; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Thiazoles; Urea; Whales | 2005 |
The SC3 hydrophobin self-assembles into a membrane with distinct mass transfer properties.
Topics: Air; Amyloid beta-Peptides; Benzothiazoles; Biophysics; Fungal Proteins; Membrane Proteins; Membranes; Microscopy, Confocal; Microscopy, Fluorescence; Octoxynol; Oils; Paraffin; Permeability; Protein Conformation; Protein Structure, Secondary; Schizophyllum; Thiazoles; Time Factors; Water | 2005 |
Unfolding, aggregation, and seeded amyloid formation of lysine-58-cleaved beta 2-microglobulin.
Topics: Amyloid; Benzothiazoles; beta 2-Microglobulin; Binding Sites; Chromatography, Gel; Congo Red; Deuterium Exchange Measurement; Electrophoresis, Capillary; Fluorescent Dyes; Humans; Hydrolysis; Lysine; Microscopy, Atomic Force; Protein Conformation; Protein Folding; Spectrometry, Fluorescence; Spectrometry, Mass, Electrospray Ionization; Temperature; Thiazoles; Time Factors | 2005 |
Amidation and structure relaxation abolish the neurotoxicity of the prion peptide PrP106-126 in vivo and in vitro.
Topics: Amyloid; Animals; Apoptosis; Benzothiazoles; Caspases; Cell Survival; Cells, Cultured; Cerebellum; Electroretinography; Immunohistochemistry; In Situ Nick-End Labeling; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Oxygen; Peptides; Prions; Protein Binding; Protein Conformation; Protein Isoforms; Protein Structure, Secondary; Protein Structure, Tertiary; PrPC Proteins; Rats; Recombinant Proteins; Retina; RNA, Messenger; Salts; Spectrometry, Fluorescence; Thiazoles; Time Factors | 2005 |
On the chaperonin activity of GroEL at heat-shock temperature.
Topics: Adenosine Triphosphatases; Benzothiazoles; Chaperonin 60; Heat-Shock Response; Heating; Protein Binding; Protein Conformation; Protein Denaturation; Protein Folding; Thiazoles; Thiosulfate Sulfurtransferase | 2005 |
Water-soluble hybrid nanoclusters with extra bright and photostable emissions: a new tool for biological imaging.
Topics: Amyloid; Animals; Benzothiazoles; Biophysics; Culture Techniques; Fluorescent Dyes; Insulin; Light; Mice; Microscopy, Confocal; Microscopy, Electron; Microscopy, Fluorescence; Nanostructures; Oligonucleotides; Prions; Scattering, Radiation; Silver; Sodium; Spectrometry, Fluorescence; Thiazoles; Time Factors; Water | 2005 |
Higher-order molecular packing in amyloid-like fibrils constructed with linear arrangements of hydrophobic and hydrogen-bonding side-chains.
Topics: Amyloid; Benzothiazoles; Circular Dichroism; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Microscopy, Electron, Transmission; Models, Molecular; Mutation; Protein Structure, Quaternary; Stereoisomerism; Thiazoles; X-Ray Diffraction | 2005 |
Collagenous Alzheimer amyloid plaque component assembles amyloid fibrils into protease resistant aggregates.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Fluorescent Dyes; Humans; Nerve Tissue Proteins; Non-Fibrillar Collagens; Peptide Fragments; Thiazoles | 2005 |
Delineation of positron emission tomography imaging agent binding sites on beta-amyloid peptide fibrils.
Topics: 1-Naphthylamine; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Binding Sites; Congo Red; Contrast Media; Fluorescence; Humans; Positron-Emission Tomography; Radioligand Assay; Thiazoles | 2005 |
Activity, folding, misfolding, and aggregation in vitro of the naturally occurring human tissue factor mutant R200W.
Topics: Amyloid; Anilino Naphthalenesulfonates; Arginine; Benzothiazoles; Extracellular Space; Factor VIIa; Genetic Carrier Screening; Humans; Kinetics; Mutation; Nephelometry and Turbidimetry; Protein Binding; Protein Denaturation; Protein Folding; Spectrometry, Fluorescence; Substrate Specificity; Thiazoles; Thromboplastin; Tryptophan | 2005 |
Protective effect of donepezil against Abeta(1-40) neurotoxicity in rat septal neurons.
Topics: Acetylcholine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Cells, Cultured; Cholinergic Fibers; Cholinesterase Inhibitors; Donepezil; Down-Regulation; Fluorescent Dyes; Immunohistochemistry; Indans; L-Lactate Dehydrogenase; Membrane Transport Proteins; Molecular Structure; Neurons; Neuroprotective Agents; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Septal Nuclei; Thiazoles; Vesicular Acetylcholine Transport Proteins | 2005 |
Transformation of diffuse beta-amyloid precursor protein and beta-amyloid deposits to plaques in the thalamus after transient occlusion of the middle cerebral artery in rats.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Axons; Benzothiazoles; Brain Ischemia; Cerebral Arterial Diseases; Coloring Agents; Congo Red; Corpus Callosum; Fluorescent Dyes; Immunohistochemistry; Infarction, Middle Cerebral Artery; Male; Middle Cerebral Artery; Neurons; Protein Structure, Tertiary; Rats; Rats, Wistar; Thalamus; Thiazoles; Time Factors; Treatment Outcome; Ventral Thalamic Nuclei; Ventromedial Hypothalamic Nucleus | 2005 |
The aggregation kinetics of Alzheimer's beta-amyloid peptide is controlled by stochastic nucleation.
Topics: Amyloid beta-Peptides; Benzothiazoles; Circular Dichroism; Computer Simulation; Endopeptidases; Histidine; Humans; Kinetics; Mutation; Peptide Fragments; Protein Conformation; Protein Folding; Solubility; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2005 |
Dopamine promotes alpha-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway.
Topics: alpha-Synuclein; Amyloid; Benzothiazoles; Circular Dichroism; Dopamine; Ferric Compounds; Humans; Parkinson Disease; Protein Folding; Protein Structure, Secondary; Sodium Dodecyl Sulfate; Thiazoles | 2005 |
Ethanol-perturbed amyloidogenic self-assembly of insulin: looking for origins of amyloid strains.
Topics: Amyloid; Anilino Naphthalenesulfonates; Animals; Benzothiazoles; Calorimetry; Cattle; Circular Dichroism; Ethanol; Insulin; Microscopy, Atomic Force; Protein Denaturation; Protein Structure, Quaternary; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Temperature; Thiazoles; Titrimetry | 2005 |
Oxidation of low-density lipoproteins induces amyloid-like structures that are recognized by macrophages.
Topics: Amyloid; Animals; Benzothiazoles; Cells, Cultured; Chromatography, Gel; Congo Red; Humans; Lipoproteins, LDL; Macrophages; Mice; Microscopy, Electron, Transmission; Oxidation-Reduction; Spectrometry, Fluorescence; Thiazoles; X-Ray Diffraction | 2005 |
Walnut extract inhibits the fibrillization of amyloid beta-protein, and also defibrillizes its preformed fibrils.
Topics: Amyloid; Amyloid beta-Peptides; Benzothiazoles; Dose-Response Relationship, Drug; Fluorescent Dyes; Juglans; Methanol; Microscopy, Electron; Plant Extracts; Solvents; Spectrometry, Fluorescence; Thiazoles; Time Factors | 2004 |
Purification of recombinant tau protein and preparation of Alzheimer-paired helical filaments in vitro.
Topics: Alzheimer Disease; Amyloid; Benzothiazoles; Cloning, Molecular; Humans; Microscopy, Electron; Protein Isoforms; Spectrometry, Fluorescence; tau Proteins; Thiazoles | 2005 |
Histological staining of amyloid-beta in mouse brains.
Topics: Amyloid beta-Peptides; Animals; Antibodies, Monoclonal; Benzothiazoles; Brain; Congo Red; Gelatin; Immunohistochemistry; Mice; Thiazoles | 2005 |
Circular dichroism and aggregation studies of amyloid beta (11-8) fragment and its variants.
Topics: Amyloid beta-Peptides; Benzothiazoles; Circular Dichroism; Protein Structure, Secondary; Thiazoles | 2005 |
Aluminum-triggered structural modifications and aggregation of beta-amyloids.
Topics: Aluminum; Amyloid beta-Peptides; Benzothiazoles; Chelating Agents; Circular Dichroism; Deferoxamine; Fluorescent Dyes; Hydrophobic and Hydrophilic Interactions; Liposomes; Peptide Fragments; Protein Conformation; Spectrometry, Fluorescence; Thiazoles | 2005 |
Rational design of aggregation-resistant bioactive peptides: reengineering human calcitonin.
Topics: Benzothiazoles; Biopharmaceutics; Calcitonin; Cells, Cultured; Chromatography, High Pressure Liquid; Cyclic AMP; Humans; Kinetics; Microscopy, Electron; Protein Binding; Protein Engineering; Solubility; Thiazoles | 2005 |
Thermostable direct hemolysin of Vibrio parahaemolyticus is a bacterial reversible amyloid toxin.
Topics: Amyloid; Amyloid beta-Peptides; Animals; Bacterial Proteins; Bacterial Toxins; Benzothiazoles; Circular Dichroism; Congo Red; Hemolysin Proteins; Hot Temperature; Models, Biological; Models, Chemical; Molecular Weight; Protein Conformation; Rabbits; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Thiazoles; Virulence Factors | 2005 |
Inducible neuronal expression of transgenic TGF-beta1 in vivo: dissection of short-term and long-term effects.
Topics: Animals; Anti-Bacterial Agents; Apolipoproteins E; Benzothiazoles; Brain; Doxycycline; Gene Expression Regulation; Gene Silencing; Mice; Mice, Transgenic; Molecular Biology; Nerve Degeneration; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Neurotoxins; Nitro Compounds; Plaque, Amyloid; Propionates; Thiazoles; Transfection; Transforming Growth Factor beta; Transforming Growth Factor beta1; Transgenes | 2005 |
Haploinsufficiency for trkB and trkC receptors induces cell loss and accumulation of alpha-synuclein in the substantia nigra.
Topics: Aging; Alkaloids; alpha-Synuclein; Animals; Axons; Benzothiazoles; Brain-Derived Neurotrophic Factor; Crosses, Genetic; Densitometry; Dopamine; Fluorescent Dyes; Heterozygote; Immunohistochemistry; Indoles; Ligands; Male; Mice; Mutation; Neurons; Parkinson Disease; Phenotype; Quinolines; Receptor, trkB; Receptor, trkC; Signal Transduction; Substantia Nigra; Thiazoles; Tyrosine 3-Monooxygenase | 2005 |
Abeta42 is essential for parenchymal and vascular amyloid deposition in mice.
Topics: Age Factors; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Blood Vessels; Blotting, Northern; Blotting, Western; Brain; Cerebral Amyloid Angiopathy; Enzyme-Linked Immunosorbent Assay; Female; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; Immunoprecipitation; In Situ Hybridization; Male; Mass Spectrometry; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Mutation; Peptide Fragments; Pia Mater; Plaque, Amyloid; Thiazoles | 2005 |
Controlling {beta}-amyloid oligomerization by the use of naphthalene sulfonates: trapping low molecular weight oligomeric species.
Topics: Amyloid; Amyloid beta-Peptides; Anilino Naphthalenesulfonates; Animals; Anions; Benzothiazoles; Biochemistry; Cell Line; Chromatography; Congo Red; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Fluorescent Dyes; Hydrogen-Ion Concentration; Kinetics; Light; Lysine; Magnetic Resonance Spectroscopy; Mice; Micelles; Models, Chemical; Models, Molecular; Molecular Conformation; Molecular Weight; Naphthalenesulfonates; Peptide Fragments; Peptides; Phenylalanine; Prions; Protein Structure, Secondary; Scattering, Radiation; Sodium Dodecyl Sulfate; Spectrophotometry; Static Electricity; Sulfonic Acids; Temperature; Tetrazolium Salts; Thiazoles; Time Factors | 2005 |
Cyanine dye N744 inhibits tau fibrillization by blocking filament extension: implications for the treatment of tauopathic neurodegenerative diseases.
Topics: Benzothiazoles; Binding, Competitive; Carbocyanines; Humans; Kinetics; Models, Chemical; Nerve Tissue Proteins; Protein Processing, Post-Translational; Solubility; tau Proteins; Tauopathies; Thiazoles | 2005 |
Ultrasonication-induced amyloid fibril formation of beta2-microglobulin.
Topics: Amyloid; Benzothiazoles; beta 2-Microglobulin; Circular Dichroism; Humans; Hydrogen-Ion Concentration; Light; Microscopy, Atomic Force; Protein Conformation; Protein Denaturation; Protein Structure, Secondary; Recombinant Proteins; Scattering, Radiation; Sodium Dodecyl Sulfate; Sonication; Thiazoles; Time Factors | 2005 |
Influence of the N-terminal domain on the aggregation properties of the prion protein.
Topics: Animals; Benzothiazoles; Chromatography, Gel; Kinetics; Light; Mice; Nephelometry and Turbidimetry; Peptide Fragments; Prions; Protein Conformation; Protein Structure, Tertiary; Scattering, Radiation; Sequence Deletion; Thiazoles | 2005 |
Cooexpression of FTDP-17 tau and GSK-3beta in transgenic mice induce tau polymerization and neurodegeneration.
Topics: Animals; Benzothiazoles; Biomarkers; Blotting, Western; Dentate Gyrus; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Immunohistochemistry; Mice; Mice, Transgenic; Microtubule-Associated Proteins; Nerve Degeneration; Neurofilament Proteins; Phosphorylation; tau Proteins; Thiazoles | 2006 |
Amyloid-like fibril formation of co-chaperonin GroES: nucleation and extension prefer different degrees of molecular compactness.
Topics: Amyloid; Benzothiazoles; Carrier Proteins; Chaperonin 10; Circular Dichroism; Coloring Agents; Congo Red; Dose-Response Relationship, Drug; Escherichia coli; Guanidine; Hydrogen-Ion Concentration; Light; Mass Spectrometry; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Molecular Conformation; Protein Binding; Protein Conformation; Protein Folding; Protein Structure, Secondary; Scattering, Radiation; Thiazoles; Time Factors | 2005 |
Effects of the sequence and size of non-polar residues on self-assembly of amphiphilic peptides.
Topics: Alanine; Amino Acid Motifs; Amyloid; Benzothiazoles; Circular Dichroism; Congo Red; Gene Library; Glycine; Hydrogel, Polyethylene Glycol Dimethacrylate; Isoleucine; Leucine; Macromolecular Substances; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Models, Molecular; Peptides; Phenylalanine; Protein Binding; Protein Conformation; Protein Folding; Protein Structure, Secondary; Temperature; Thiazoles; Ultraviolet Rays; Valine; X-Ray Diffraction | 2005 |
Multiple ligand binding sites on A beta(1-40) fibrils.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Binding Sites; Congo Red; Fluorescent Dyes; Humans; Ibuprofen; Ligands; Models, Chemical; Molecular Structure; Naproxen; Peptide Fragments; Protein Binding; Thiazoles | 2005 |
Sequence determinants of enhanced amyloidogenicity of Alzheimer A{beta}42 peptide relative to A{beta}40.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Biophysical Phenomena; Biophysics; Chromatography, High Pressure Liquid; DNA Primers; Green Fluorescent Proteins; Humans; Kinetics; Microscopy, Fluorescence; Models, Chemical; Mutation; Peptide Fragments; Peptide Library; Peptides; Phenotype; Protein Structure, Secondary; Recombinant Fusion Proteins; Sequence Analysis, Protein; Temperature; Thiazoles; Time Factors | 2005 |
Main-chain dominated amyloid structures demonstrated by the effect of high pressure.
Topics: Amyloid; Benzothiazoles; beta 2-Microglobulin; Dialysis; Guanidine; Humans; Hydrostatic Pressure; Protein Conformation; Protein Denaturation; Protein Folding; Thiazoles; Tryptophan | 2005 |
Mechanism of thioflavin T binding to amyloid fibrils.
Topics: Amyloid; Benzothiazoles; Binding Sites; Deuterium; Fluorescence; Fluorescence Polarization; Fluorescent Dyes; Hydrogen-Ion Concentration; Micelles; Microscopy, Atomic Force; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Solutions; Spectroscopy, Fourier Transform Infrared; Thiazoles; Water | 2005 |
Nonfibrous beta-structured aggregation of an Abeta model peptide (Ad-2alpha) on GM1/DPPC mixed monolayer surfaces.
Topics: Adsorption; Amyloid; Animals; Benzothiazoles; Cattle; Circular Dichroism; Glycolipids; Kinetics; Microscopy, Atomic Force; Microscopy, Fluorescence; Models, Chemical; Peptides; Protein Structure, Secondary; Proteins; Quartz; Thiazoles | 2006 |
Hydrogen peroxide is generated during the very early stages of aggregation of the amyloid peptides implicated in Alzheimer disease and familial British dementia.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Dementia; Electron Spin Resonance Spectroscopy; Enzyme-Linked Immunosorbent Assay; Family Health; Humans; Hydrogen Peroxide; Microscopy, Atomic Force; Models, Statistical; Neurodegenerative Diseases; Oxidative Stress; Oxygen; Peptide Fragments; Peptides; Spin Trapping; Thiazoles; Time Factors; United Kingdom | 2005 |
Amyloid fibril formation of alpha-synuclein is accelerated by preformed amyloid seeds of other proteins: implications for the mechanism of transmissible conformational diseases.
Topics: alpha-Synuclein; Amyloid; Animals; Benzothiazoles; Biochemistry; Cattle; Chaperonin 10; Chickens; Circular Dichroism; Escherichia coli; Humans; Insulin; Lewy Bodies; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Models, Biological; Molecular Chaperones; Muramidase; Parkinson Disease; Peptides; Protein Binding; Protein Conformation; Scattering, Radiation; Thiazoles; X-Rays | 2005 |
Helix-turn-helix peptides that form alpha-helical fibrils: turn sequences drive fibril structure.
Topics: Amino Acid Sequence; Amyloid; Apolipoprotein A-I; Benzothiazoles; Circular Dichroism; Congo Red; Fluorescent Dyes; Lipid Bilayers; Models, Molecular; Molecular Sequence Data; Peptides; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared; Thiazoles; X-Ray Diffraction | 2005 |
Thermodynamics of A beta(1-40) amyloid fibril elongation.
Topics: Amyloid beta-Peptides; Benzothiazoles; Chromatography, High Pressure Liquid; Deuterium Exchange Measurement; Kinetics; Peptide Fragments; Point Mutation; Protein Folding; Thermodynamics; Thiazoles | 2005 |
Characterization of oligomeric intermediates in alpha-synuclein fibrillation: FRET studies of Y125W/Y133F/Y136F alpha-synuclein.
Topics: alpha-Synuclein; Anilino Naphthalenesulfonates; Benzothiazoles; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Humans; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Parkinson Disease; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared; Synucleins; Thiazoles; Tryptophan; Tyrosine | 2005 |
Protective effect of zinc on amyloid-beta 25-35 and 1-40 mediated toxicity.
Topics: Amyloid beta-Peptides; Apoptosis; Benzothiazoles; Caspase 3; Caspases; Cell Line; Coloring Agents; Congo Red; Cytochromes c; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Microscopy, Confocal; Mitochondria; Neurotoxins; Peptide Fragments; Protein Structure, Secondary; Thiazoles; Zinc | 2005 |
Structural studies reveal that the diverse morphology of beta(2)-microglobulin aggregates is a reflection of different molecular architectures.
Topics: Amyloid; Benzothiazoles; beta 2-Microglobulin; Circular Dichroism; Deuterium Exchange Measurement; Humans; Microscopy, Atomic Force; Protein Structure, Quaternary; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared; Thiazoles; Ultracentrifugation | 2005 |
Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Apolipoproteins E; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Benzothiazoles; Blotting, Western; Brain; Enzyme-Linked Immunosorbent Assay; Gene Deletion; Heterozygote; Hippocampus; Mice; Mice, Transgenic; Models, Genetic; Protein Structure, Tertiary; Thiazoles; Time Factors | 2005 |
Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Apolipoproteins E; Atherosclerosis; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Benzothiazoles; Blotting, Western; Brain; Cerebral Amyloid Angiopathy; Humans; Immunohistochemistry; Lipid Metabolism; Lipoproteins, HDL; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Mice, Transgenic; Mutation; Protein Isoforms; Thiazoles; Time Factors | 2005 |
The mitochondrial complex I inhibitor rotenone triggers a cerebral tauopathy.
Topics: alpha-Synuclein; Amyloid beta-Peptides; Analysis of Variance; Animals; Antineoplastic Combined Chemotherapy Protocols; Behavior, Animal; Benzothiazoles; Body Weight; Caspase 3; Caspases; Cell Death; Cerebral Cortex; Cytarabine; Diagnostic Imaging; Dopamine and cAMP-Regulated Phosphoprotein 32; Doxorubicin; Dystonia; Electron Transport Complex III; Enzyme Activation; Glial Fibrillary Acidic Protein; Immunohistochemistry; Locomotion; Male; Microscopy, Electron, Transmission; Mitochondria; Neurons; Phosphopyruvate Hydratase; Phosphorylation; Posture; Psychomotor Performance; Rats; Rats, Inbred Lew; Rotenone; tau Proteins; Tauopathies; Thiazoles; Time Factors; Tyrosine; Tyrosine 3-Monooxygenase; Ubiquitin; Uncoupling Agents | 2005 |
Inhibitory effect of minocycline on amyloid beta fibril formation and human microglial activation.
Topics: Amyloid beta-Peptides; Anti-Bacterial Agents; Benzothiazoles; Brain; Cell Count; Cells, Cultured; Complement C1q; Cytokines; Enzyme-Linked Immunosorbent Assay; Humans; In Vitro Techniques; Macrophage Activation; Microglia; Minocycline; Neurofibrils; Serum Amyloid P-Component; Stimulation, Chemical; Tetracycline; Thiazoles | 2006 |
Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans.
Topics: 3-Hydroxybutyric Acid; alpha-Synuclein; Amino Acid Sequence; Animals; Animals, Genetically Modified; Antioxidants; Apoptosis; Benzoates; Benzothiazoles; Bile Acids and Salts; Caenorhabditis elegans; Cholagogues and Choleretics; Copper; Disease Models, Animal; Electron Transport Complex I; Gene Deletion; Gene Expression Regulation; Gene Library; Genetic Techniques; Humans; Immunoblotting; Intracellular Signaling Peptides and Proteins; Ions; Iron; Mitochondria; Molecular Sequence Data; Mutagenesis; Mutation; Neurons; Oncogene Proteins; Oxygen Consumption; Paraquat; Parkinson Disease; Polyenes; Probucol; Protein Deglycase DJ-1; Pyrazoles; Pyridazines; RNA, Small Interfering; Rotenone; Sequence Homology, Amino Acid; Sodium Azide; Taurochenodeoxycholic Acid; Thiazoles; Time Factors; Transgenes; Ubiquitin-Protein Ligases | 2005 |
Cerebrospinal fluid of Alzheimer patients promotes beta-amyloid fibril formation in vitro.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Brain; Brain Chemistry; Cerebrospinal Fluid; Humans; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Middle Aged; Peptide Fragments; Plaque, Amyloid; Polymers; Thiazoles | 2005 |
Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs.
Topics: Alzheimer Disease; Amino Acid Motifs; Benzothiazoles; Brain; Cell Line; Cell Line, Tumor; Centrifugation, Density Gradient; Chromatography; DNA Fragmentation; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Gene Deletion; Humans; Mass Spectrometry; Microscopy, Electron; Microscopy, Fluorescence; Models, Biological; Models, Chemical; Mutation; Neurons; Peptide Hydrolases; Phosphorylation; Plasmids; Protein Binding; Protein Isoforms; Protein Structure, Tertiary; tau Proteins; Tauopathies; Thiazoles; Thrombin; Time Factors | 2006 |
Early events in the fibrillation of monomeric insulin.
Topics: Acetic Acid; Anilino Naphthalenesulfonates; Benzothiazoles; Circular Dichroism; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Insulin; Kinetics; Light; Mass Spectrometry; Molecular Conformation; Protein Conformation; Protein Folding; Protein Structure, Secondary; Scattering, Radiation; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared; Thiazoles; Time Factors; Ultraviolet Rays | 2005 |
In vivo magnetic resonance microimaging of individual amyloid plaques in Alzheimer's transgenic mice.
Topics: Age Factors; Alzheimer Disease; Animals; Benzothiazoles; Brain Mapping; Disease Models, Animal; Magnetic Resonance Imaging; Mice; Mice, Transgenic; Plaque, Amyloid; Staining and Labeling; Thiazoles | 2005 |
Scanning cysteine mutagenesis analysis of Abeta-(1-40) amyloid fibrils.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Benzothiazoles; Chromatography, High Pressure Liquid; Cysteine; Cystine; Electron Spin Resonance Spectroscopy; Humans; Hydrocarbons, Iodinated; Iodoacetic Acid; Kinetics; Microscopy, Electron; Models, Molecular; Molecular Sequence Data; Mutagenesis; Mutation; Peptide Fragments; Peptide Mapping; Peptides; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Solvents; Thermodynamics; Thiazoles; Time Factors | 2006 |
Deficiency of disulfide bonds facilitating fibrillogenesis of endostatin.
Topics: Alanine; Alzheimer Disease; Animals; Benzothiazoles; Cell Survival; Circular Dichroism; Disulfides; Endostatins; Escherichia coli; Fibril-Associated Collagens; Fluorescent Dyes; Glutathione; Hydrogen-Ion Concentration; Light; Microscopy, Atomic Force; Neovascularization, Pathologic; PC12 Cells; Protein Conformation; Protein Structure, Tertiary; Rats; Scattering, Radiation; Spectroscopy, Fourier Transform Infrared; Temperature; Tetrazolium Salts; Thiazoles; Time Factors; Tryptophan; Ultraviolet Rays | 2006 |
Inhibiting protein-amyloid interactions with small molecules: a surface chemistry approach.
Topics: Acridines; Amyloid; Benzothiazoles; Enzyme-Linked Immunosorbent Assay; Immunoglobulin G; Molecular Structure; Proflavine; Protein Binding; Proteins; Surface Properties; Thiazoles | 2006 |
Chiral bias of amyloid fibrils revealed by the twisted conformation of Thioflavin T: an induced circular dichroism/DFT study.
Topics: Amyloid beta-Peptides; Benzothiazoles; Circular Dichroism; Fluorescent Dyes; Insulin; Models, Molecular; Protein Binding; Protein Conformation; Spectrometry, Fluorescence; Thiazoles | 2005 |
Functional amyloid formation within mammalian tissue.
Topics: Amyloid; Animals; Benzothiazoles; Cattle; Congo Red; Eye; gp100 Melanoma Antigen; Melanins; Melanosomes; Membrane Glycoproteins; Microscopy, Electron; Microscopy, Fluorescence; Molecular Sequence Data; Peptide Fragments; Protein Folding; Proteins; Recombinant Proteins; Spectroscopy, Fourier Transform Infrared; Staining and Labeling; Thiazoles; X-Ray Diffraction | 2006 |
Influence of heparin and dendrimers on the aggregation of two amyloid peptides related to Alzheimer's and prion diseases.
Topics: Alzheimer Disease; Amyloid; Benzothiazoles; Dendrimers; Heparin; Kinetics; Molecular Structure; Peptide Fragments; Prion Diseases; Spectrometry, Fluorescence; Thiazoles | 2006 |
The role of His-18 in amyloid formation by human islet amyloid polypeptide.
Topics: Amino Acid Sequence; Amyloid; Benzothiazoles; Histidine; Humans; Hydrogen-Ion Concentration; Islet Amyloid Polypeptide; Molecular Sequence Data; Sequence Alignment; Thiazoles | 2005 |
Synthesis of 6-[2-(benzoxazol-2-ylmethylamino)ethoxy]-1-alkyl-1H-indole-2-carboxylic acid and inhibitory activity on beta-amyloid aggregation.
Topics: Amyloid beta-Peptides; Benzothiazoles; Benzoxazoles; Indicators and Reagents; Indoles; Magnetic Resonance Spectroscopy; Neurofibrils; Solvents; Spectrometry, Fluorescence; Thiazoles | 2005 |
Amyloid fibril formation by bovine milk kappa-casein and its inhibition by the molecular chaperones alphaS- and beta-casein.
Topics: Amyloid; Anilino Naphthalenesulfonates; Animals; Benzothiazoles; Caseins; Cattle; Dithiothreitol; Mercaptoethanol; Microscopy, Electron, Transmission; Milk Proteins; Models, Chemical; Molecular Chaperones; Oxidation-Reduction; Serum Albumin, Bovine; Spectrometry, Fluorescence; Temperature; Thiazoles; X-Ray Diffraction | 2005 |
Structure of amyloid beta fragments in aqueous environments.
Topics: Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Circular Dichroism; Crystallography, X-Ray; Enzyme Stability; Fibrillar Collagens; Humans; Molecular Sequence Data; Mutation; Peptide Fragments; Protein Binding; Protein Structure, Tertiary; Recombinant Proteins; Ribonuclease H; Thermococcus; Thiazoles; Time Factors; Water | 2006 |
Formation of tau inclusions in knock-in mice with familial Alzheimer disease (FAD) mutation of presenilin 1 (PS1).
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Benzothiazoles; Blotting, Western; Brain; Congo Red; Endopeptidases; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Heterozygote; Hippocampus; Immunohistochemistry; Membrane Proteins; Mice; Mice, Transgenic; Microscopy, Electron; Mutation; Mutation, Missense; Neurons; Peptide Fragments; Phosphorylation; Presenilin-1; Protein Conformation; Sodium Dodecyl Sulfate; tau Proteins; Thiazoles | 2006 |
Shear flow induces amyloid fibril formation.
Topics: Amyloid; Amyloidosis; Animals; Benzothiazoles; Cattle; Lactoglobulins; Microscopy, Atomic Force; Protein Structure, Quaternary; Rheology; Spectrometry, Fluorescence; Thiazoles | 2006 |
Mutagenesis of the central hydrophobic cluster in Abeta42 Alzheimer's peptide. Side-chain properties correlate with aggregation propensities.
Topics: Amyloid beta-Peptides; Benzothiazoles; Cell Line; Circular Dichroism; Escherichia coli; Green Fluorescent Proteins; Humans; Hydrophobic and Hydrophilic Interactions; Microscopy, Electron; Mutagenesis, Site-Directed; Peptide Fragments; Protein Conformation; Protein Structure, Secondary; Recombinant Fusion Proteins; Spectrometry, Fluorescence; Thiazoles | 2006 |
Structural basis of the cofactor function of denatured albumin in plasminogen activation by tissue-type plasminogen activator.
Topics: Benzothiazoles; Electrophoresis, Polyacrylamide Gel; Humans; Particle Size; Plasminogen; Protein Denaturation; Serum Albumin; Thiazoles; Tissue Plasminogen Activator | 2006 |
Role of N-terminal familial mutations in prion protein fibrillization and prion amyloid propagation in vitro.
Topics: Amyloid; Benzothiazoles; Escherichia coli; Genetic Predisposition to Disease; Humans; In Vitro Techniques; Kinetics; Methionine; Microscopy, Atomic Force; Molecular Conformation; Mutation; Plasmids; Polymorphism, Genetic; Prion Diseases; Prions; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Spectroscopy, Fourier Transform Infrared; Thiazoles; Time Factors; Valine | 2006 |
Alpha-lipoic acid exhibits anti-amyloidogenicity for beta-amyloid fibrils in vitro.
Topics: Amyloid; Amyloid beta-Peptides; Benzothiazoles; Masoprocol; Microscopy, Electron; Rifampin; Spectrometry, Fluorescence; Tetracycline; Thiazoles; Thioctic Acid | 2006 |
Peripheral region for core cross-beta plays important role in amyloidogenicity.
Topics: Amino Acids; Amyloidosis; Bacterial Proteins; Benzothiazoles; Binding Sites; Circular Dichroism; Fluorescence; Models, Molecular; Peptide Fragments; Peptide Library; Ribonucleases; Sequence Analysis, Protein; Thiazoles | 2006 |
A systematic screen of beta(2)-microglobulin and insulin for amyloid-like segments.
Topics: Amino Acid Sequence; Amyloid; Benzothiazoles; beta 2-Microglobulin; Biophysical Phenomena; Biophysics; Congo Red; Crystallography, X-Ray; Humans; Insulin; Microscopy, Electron; Models, Molecular; Molecular Sequence Data; Oligopeptides; Peptide Fragments; Protein Structure, Quaternary; Protein Structure, Secondary; Thiazoles | 2006 |
alphaB-crystallin maintains skeletal muscle myosin enzymatic activity and prevents its aggregation under heat-shock stress.
Topics: alpha-Crystallin B Chain; Animals; Benzothiazoles; Chickens; Heat-Shock Proteins; Microscopy, Electron; Protein Binding; Protein Denaturation; Protein Folding; Skeletal Muscle Myosins; Temperature; Thiazoles | 2006 |
Mechanism of thioflavin T accumulation inside cells overexpressing P-glycoprotein or multidrug resistance-associated protein: role of lipophilicity and positive charge.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzothiazoles; Blood-Brain Barrier; Cell Line, Tumor; Cell Membrane; Humans; Leukemia, Erythroblastic, Acute; Lipid Metabolism; Metabolic Clearance Rate; Multidrug Resistance-Associated Proteins; Static Electricity; Thiazoles | 2006 |
Fluorescence-coupled CD conformational monitoring of filament formation of tau microtubule-binding repeat domain.
Topics: Amino Acid Sequence; Benzothiazoles; Circular Dichroism; Fluorescence; Heparin; Humans; Molecular Sequence Data; Peptides; Protein Structure, Secondary; Repetitive Sequences, Amino Acid; tau Proteins; Thiazoles | 2006 |
Kinetics of insulin aggregation: disentanglement of amyloid fibrillation from large-size cluster formation.
Topics: Amyloid; Benzothiazoles; Computer Simulation; Humans; Insulin; Kinetics; Models, Chemical; Models, Molecular; Multiprotein Complexes; Particle Size; Thiazoles | 2006 |
Proteasomal inhibition hypersensitizes differentiated neuroblastoma cells to oxidative damage.
Topics: alpha-Synuclein; Benzothiazoles; Cell Differentiation; Cell Line, Tumor; Cytoplasm; Ferrous Compounds; Humans; Immunohistochemistry; Molsidomine; Mutation; Neuroblastoma; Oxidative Stress; Parkinson Disease; Proteasome Inhibitors; Reactive Oxygen Species; Rotenone; Thiazoles; Ubiquitin | 2006 |
Assessing the role of aromatic residues in the amyloid aggregation of human muscle acylphosphatase.
Topics: Acid Anhydride Hydrolases; Acylphosphatase; Amino Acid Substitution; Amyloid; Benzothiazoles; Birefringence; Circular Dichroism; Congo Red; Data Interpretation, Statistical; Humans; Hydrophobic and Hydrophilic Interactions; Muscles; Phase Transition; Phenylalanine; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared; Thiazoles; Trifluoroethanol; Tyrosine | 2006 |
Collagen plays an active role in the aggregation of beta2-microglobulin under physiopathological conditions of dialysis-related amyloidosis.
Topics: Amyloid; Amyloidosis; Benzothiazoles; beta 2-Microglobulin; Collagen; Dialysis; Extracellular Matrix; Humans; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Microscopy, Atomic Force; Microscopy, Fluorescence; Polylysine; Temperature; Thiazoles | 2006 |
Methods for enhancing the accuracy and reproducibility of Congo red and thioflavin T assays.
Topics: Amyloid; Benzothiazoles; Biological Assay; Coloring Agents; Congo Red; Fluorescent Dyes; Reproducibility of Results; Thiazoles | 2006 |
The two-stage pathway of ataxin-3 fibrillogenesis involves a polyglutamine-independent step.
Topics: Ataxin-3; Benzothiazoles; Biochemistry; Escherichia coli; Humans; Kinetics; Microscopy, Electron, Transmission; Nerve Tissue Proteins; Nuclear Proteins; Peptides; Protein Binding; Recombinant Proteins; Repressor Proteins; Sodium Dodecyl Sulfate; Spectrometry, Fluorescence; Thiazoles; Tryptophan; Ubiquitin | 2006 |
Inhibitors of amyloid toxicity based on beta-sheet packing of Abeta40 and Abeta42.
Topics: Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Animals; Benzothiazoles; Fluorescent Dyes; Glycine; Humans; Methionine; Microscopy, Electron; Molecular Sequence Data; Neurons; Nuclear Magnetic Resonance, Biomolecular; Oligopeptides; Peptide Fragments; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Spectrometry, Fluorescence; Thiazoles | 2006 |
[Dynamics of in vitro amyloid fiber formation of yeast prion protein Sup35NM].
Topics: Amyloid beta-Peptides; Benzothiazoles; Electrophoresis, Polyacrylamide Gel; Endopeptidase K; Kinetics; Microscopy, Electron; Peptide Termination Factors; Prions; Protein Binding; Recombinant Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Thiazoles | 2006 |
Uncaria rhynchophylla, a Chinese medicinal herb, has potent antiaggregation effects on Alzheimer's beta-amyloid proteins.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Fluorescent Dyes; Microscopy, Atomic Force; Thiazoles; Uncaria | 2006 |
Frontotemporal dementia: clinicopathological correlations.
Topics: Adult; Age of Onset; Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Brain; Dementia; Diagnosis, Differential; Female; Humans; Immunohistochemistry; Inclusion Bodies; Male; Middle Aged; Neurodegenerative Diseases; Neuropsychological Tests; Tauopathies; Thiazoles; Ubiquitin | 2006 |
Intermediate amyloid oligomers of lysozyme: Is their cytotoxicity a particular case or general rule for amyloid?
Topics: Amyloid; Amyloid beta-Peptides; Amyloidosis; Animals; Benzothiazoles; Cell Line, Tumor; Cell Survival; Cells, Cultured; Congo Red; Dimerization; Female; Horses; Humans; Hydrogen-Ion Concentration; Kinetics; Macromolecular Substances; Mice; Mice, Inbred BALB C; Microscopy, Atomic Force; Models, Molecular; Muramidase; Protein Structure, Secondary; Thiazoles | 2006 |
Cu(II) induces small-size aggregates with amyloid characteristics in two alleles of recombinant ovine prion proteins.
Topics: Alleles; Amyloid; Animals; Benzothiazoles; Cations, Divalent; Circular Dichroism; Copper; Endopeptidase K; Hot Temperature; Hydrolysis; Light; Particle Size; Peptide Fragments; Polymorphism, Genetic; Protein Denaturation; Protein Structure, Secondary; PrPC Proteins; Recombinant Proteins; Scattering, Radiation; Sheep; Sodium Chloride; Spectrometry, Fluorescence; Thiazoles; Zinc | 2006 |
Memory-related deficits following selective hippocampal expression of Swedish mutation amyloid precursor protein in the rat.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Behavior, Animal; Benzothiazoles; Disease Models, Animal; Fluoresceins; Gene Expression; Genetic Vectors; Hippocampus; Humans; Immunohistochemistry; Male; Maze Learning; Memory Disorders; Mutation; Organic Chemicals; Peptide Fragments; Rats; Rats, Sprague-Dawley; Thiazoles | 2006 |
Molecular interactions of dendrimers with amyloid peptides: pH dependence.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Benzothiazoles; Dendrimers; Hydrogen-Ion Concentration; Ions; Molecular Sequence Data; Peptide Fragments; Thiazoles | 2006 |
Lipophilic analogs of thioflavin S as novel amyloid-imaging agents.
Topics: Affinity Labels; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Binding, Competitive; Carbon Radioisotopes; Diagnostic Imaging; Drug Evaluation, Preclinical; Fluorescent Dyes; Humans; Iodine Radioisotopes; Mice; Molecular Structure; Neurofibrillary Tangles; Plaque, Amyloid; Protein Binding; Radionuclide Imaging; Radiopharmaceuticals; Thiazoles | 2006 |
Characterisation of the binding of amyloid imaging tracers to rodent Abeta fibrils and rodent-human Abeta co-polymers.
Topics: Amyloid beta-Peptides; Animals; Benzothiazoles; Humans; Ligands; Mice; Molecular Structure; Protein Binding; Spectrometry, Fluorescence; Thiazoles; Tritium | 2006 |
Inhibition of human IAPP fibril formation does not prevent beta-cell death: evidence for distinct actions of oligomers and fibrils of human IAPP.
Topics: Adenoviridae; Amyloid beta-Protein Precursor; Animals; Apoptosis; Benzothiazoles; Blotting, Western; Cell Death; Coloring Agents; DNA, Complementary; Fluorescent Dyes; Humans; In Situ Nick-End Labeling; Insulin-Secreting Cells; Islets of Langerhans; Propidium; Rats; Rats, Sprague-Dawley; Rifampin; Tetrazolium Salts; Thiazoles | 2006 |
Amino-terminal domain stability mediates apolipoprotein E aggregation into neurotoxic fibrils.
Topics: Animals; Apolipoprotein E2; Apolipoprotein E3; Apolipoprotein E4; Apolipoproteins E; Benzothiazoles; Cells, Cultured; Congo Red; Mice; Models, Biological; Neurons; Protein Isoforms; Protein Structure, Quaternary; Protein Structure, Tertiary; Structure-Activity Relationship; Thermodynamics; Thiazoles | 2006 |
Characteristics of the binding of thioflavin S to tau paired helical filaments.
Topics: Alzheimer Disease; Antibodies, Blocking; Benzothiazoles; Fluorescent Antibody Technique; Heparin Lyase; Humans; Microscopy, Electron; Microscopy, Fluorescence; Neurofilament Proteins; Protein Binding; Quinones; tau Proteins; Thiazoles | 2006 |
Oligo(ethylene glycol) derivatives of thioflavin T as inhibitors of protein-amyloid interactions.
Topics: Amyloid beta-Peptides; Benzothiazoles; Catalase; Ethylene Glycol; Fluorescent Dyes; Humans; Molecular Structure; Polymers; Protein Binding; Proteins; Thiazoles | 2006 |
Amyloid fibrils formation and amorphous aggregation in concanavalin A.
Topics: Amyloid; Benzothiazoles; Concanavalin A; Fluorescence; Fluorescent Dyes; Hydrogen-Ion Concentration; Kinetics; Light; Microscopy, Atomic Force; Protein Structure, Quaternary; Scattering, Radiation; Thiazoles | 2007 |
Oleic acid inhibits amyloid formation of the intermediate of alpha-lactalbumin at moderately acidic pH.
Topics: Amyloid; Anilino Naphthalenesulfonates; Animals; Apoproteins; Benzothiazoles; Cattle; Circular Dichroism; Congo Red; Fluorescence; Hydrogen-Ion Concentration; Kinetics; Lactalbumin; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Oleic Acid; Protein Binding; Protein Structure, Quaternary; Spectrophotometry, Ultraviolet; Thiazoles | 2006 |
High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation.
Topics: Amino Acid Sequence; Amyloid; Benzothiazoles; Circular Dichroism; Copper; Cystatin B; Cystatins; Fluorescence; Humans; Hydrogen-Ion Concentration; Microscopy, Electron, Transmission; Molecular Sequence Data; Multiprotein Complexes; Mutation; Protein Conformation; Protein Isoforms; Sequence Alignment; Thiazoles | 2006 |
Age- and transgene-related changes in regional cerebral metabolism in PSAPP mice.
Topics: Aging; Amyloid beta-Protein Precursor; Animals; Autoradiography; Benzothiazoles; Brain; Brain Chemistry; Fluorescent Dyes; Fluorodeoxyglucose F18; Humans; Mice; Microscopy, Fluorescence; Presenilin-1; Radiopharmaceuticals; Thiazoles; Transgenes | 2006 |
Osmolyte trimethylamine N-oxide converts recombinant alpha-helical prion protein to its soluble beta-structured form at high temperature.
Topics: Anilino Naphthalenesulfonates; Animals; Benzothiazoles; Circular Dichroism; Electrophoresis, Polyacrylamide Gel; Endopeptidase K; Fluorescence; Hot Temperature; Humans; Hydrogen-Ion Concentration; Methylamines; Mice; Muramidase; Peptide Fragments; Prions; Protein Binding; Protein Structure, Secondary; Recombinant Proteins; Scattering, Radiation; Solubility; Thiazoles; Tryptophan | 2006 |
Inhibitor discovery targeting the intermediate structure of beta-amyloid peptide on the conformational transition pathway: implications in the aggregation mechanism of beta-amyloid peptide.
Topics: Amyloid; Amyloid beta-Peptides; Benzhydryl Compounds; Benzothiazoles; Binding Sites; Biochemistry; Circular Dichroism; Drug Evaluation, Preclinical; Fluorescence; Microscopy, Atomic Force; Models, Molecular; Morpholines; Protein Conformation; Thiazoles | 2006 |
Phage display affords peptides that modulate beta-amyloid aggregation.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Bacteriophage M13; Benzothiazoles; Light; Microscopy, Electron; Molecular Sequence Data; Peptide Library; Peptides; Scattering, Radiation; Thiazoles | 2006 |
Amyloid formation in denatured single-mutant lysozymes where residual structures are modulated.
Topics: Amyloid; Animals; Benzothiazoles; Chickens; Circular Dichroism; Fluorescence; Hydrophobic and Hydrophilic Interactions; Muramidase; Mutation, Missense; Oxidation-Reduction; Protein Conformation; Protein Denaturation; Thiazoles | 2006 |
Molecular heterosis of prion protein beta-oligomers. A potential mechanism of human resistance to disease.
Topics: Alleles; Amyloid; Benzothiazoles; Circular Dichroism; Heterozygote; Homozygote; Humans; Hybrid Vigor; Kinetics; Methionine; Prion Diseases; Prions; Thiazoles; Valine | 2006 |
Detection and characterization of protein aggregates by fluorescence microscopy.
Topics: Antibodies; Benzothiazoles; Calcitonin; Congo Red; Microscopy, Fluorescence; Oxazines; Staining and Labeling; Thiazoles | 2007 |
Cerebrospinal fluid of Alzheimer's disease and dementia with Lewy bodies patients enhances alpha-synuclein fibril formation in vitro.
Topics: Aged; Aged, 80 and over; alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Apolipoproteins E; Benzothiazoles; Female; Humans; Immunoglobulin G; Lewy Body Disease; Male; Microscopy, Electron; Middle Aged; Psychiatric Status Rating Scales; Spectrometry, Fluorescence; tau Proteins; Thiazoles | 2007 |
Characterisation and physical stability of PEGylated glucagon.
Topics: Benzothiazoles; Circular Dichroism; Drug Stability; Glucagon; Polyethylene Glycols; Protein Structure, Secondary; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2007 |
On the seeding and oligomerization of pGlu-amyloid peptides (in vitro).
Topics: Amyloid beta-Peptides; Benzothiazoles; Flow Cytometry; Fluorescent Dyes; Humans; In Vitro Techniques; Peptide Fragments; Protein Structure, Quaternary; Pyrrolidonecarboxylic Acid; Thiazoles | 2006 |
pH-dependent self-assembly of polyalanine peptides.
Topics: Benzothiazoles; Biophysics; Cell Nucleus; Humans; Hydrogen-Ion Concentration; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Muscles; Muscular Dystrophy, Oculopharyngeal; Peptides; Poly(A)-Binding Protein II; Protein Denaturation; Protein Folding; Protein Structure, Tertiary; Temperature; Thiazoles; Tyrosine | 2007 |
Direct observation of amyloid growth monitored by total internal reflection fluorescence microscopy.
Topics: Amyloid; Amyloid beta-Peptides; Benzothiazoles; Microscopy, Fluorescence; Peptide Fragments; Thiazoles | 2006 |
Sedimentation velocity analysis of amyloid oligomers and fibrils.
Topics: Amyloid; Amyloid beta-Peptides; Apolipoprotein C-II; Apolipoproteins C; Benzothiazoles; Centrifugation; Humans; Peptide Fragments; Protein Structure, Quaternary; Thiazoles; Ultracentrifugation | 2006 |
Conformation-dependent anti-amyloid oligomer antibodies.
Topics: Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Anilino Naphthalenesulfonates; Animals; Antibodies; Benzothiazoles; Circular Dichroism; Epitopes; Humans; Molecular Mimicry; Molecular Sequence Data; Neurodegenerative Diseases; Peptide Fragments; Protein Conformation; Protein Structure, Quaternary; Rabbits; Thiazoles | 2006 |
Further evidence of local ganglioside-dependent amyloid beta-protein assembly in brain.
Topics: Amyloid beta-Peptides; Benzothiazoles; Brain; Gangliosides; Humans; Indicators and Reagents; Microscopy, Electron; Mutation; Solutions; Thiazoles | 2006 |
Linear quantitation of Abeta aggregation using Thioflavin T: reduction in fibril formation by colostrinin.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Biological Assay; Biomarkers; Dose-Response Relationship, Drug; Down-Regulation; Fluorescence; Fluorescent Dyes; Humans; Intercellular Signaling Peptides and Proteins; Linear Models; Microscopy, Fluorescence; Molecular Weight; Neurochemistry; Neuroprotective Agents; Peptide Fragments; Peptides; Plaque, Amyloid; Solubility; Thiazoles | 2007 |
Kinetic studies of protein L aggregation and disaggregation.
Topics: Amyloidosis; Bacterial Proteins; Benzothiazoles; Congo Red; Dimerization; Hydrogen-Ion Concentration; Kinetics; Solutions; Thiazoles | 2007 |
Viral-induced inflammation is accompanied by beta-amyloid plaque reduction in brains of amyloid precursor protein transgenic Tg2576 mice.
Topics: Amyloid beta-Protein Precursor; Animals; Animals, Newborn; Benzothiazoles; Borna disease virus; Brain; Cytokines; Electrophoresis, Polyacrylamide Gel; Electrophoretic Mobility Shift Assay; Gene Expression; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; Inflammation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroglia; Nucleoproteins; Plaque, Amyloid; T-Lymphocytes; Thiazoles; Time Factors; Viral Proteins | 2006 |
Potential inplications of endogenous aldehydes in beta-amyloid misfolding, oligomerization and fibrillogenesis.
Topics: Aldehydes; Alzheimer Disease; Amine Oxidase (Copper-Containing); Amyloid beta-Peptides; Benzothiazoles; Brain; Cell Adhesion Molecules; Fluorometry; Formaldehyde; Humans; Lipid Peroxidation; Malondialdehyde; Microscopy, Atomic Force; Neurofibrillary Tangles; Oxidative Stress; Polymers; Protein Folding; Proteomics; Pyruvaldehyde; Spectrum Analysis; Thiazoles | 2006 |
Proline and glycine control protein self-organization into elastomeric or amyloid fibrils.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Animals; Benzothiazoles; Chickens; Elastin; Entropy; Glycine; Humans; Insecta; Models, Molecular; Molecular Sequence Data; Peptides; Proline; Protein Conformation; Thiazoles; Triticum | 2006 |
The early stages of amyloid formation: biophysical and structural characterization of human calcitonin pre-fibrillar assemblies.
Topics: Amyloid; Benzothiazoles; Calcitonin; Chromatography, Gel; Fluorescent Dyes; Humans; Light; Microscopy, Electron, Transmission; Protein Structure, Tertiary; Scattering, Radiation; Thiazoles | 2006 |
N- and C-terminal hydrophobic patches are involved in fibrillation of glucagon.
Topics: Acids; Alanine; Alkalies; Benzothiazoles; Glucagon; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kinetics; Mutation; Spectrometry, Fluorescence; Thiazoles | 2006 |
Protection by EGb 761 against beta-amyloid-induced neurotoxicity: involvement of NF-kappaB, SIRT1, and MAPKs pathways and inhibition of amyloid fibril formation.
Topics: Amyloid beta-Peptides; Benzothiazoles; Cell Survival; Flavonoids; Ginkgo biloba; Ginkgolides; Humans; Lactones; MAP Kinase Kinase 4; Microscopy, Electron; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Neuroprotective Agents; Neurotoxicity Syndromes; NF-kappa B; Plant Extracts; Plaque, Amyloid; Sirtuin 1; Sirtuins; Thiazoles; Tumor Cells, Cultured | 2006 |
Kinetics of different processes in human insulin amyloid formation.
Topics: Amyloid; Benzothiazoles; Fluorescence; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Insulin; Kinetics; Microscopy, Atomic Force; Microscopy, Phase-Contrast; Models, Biological; Particle Size; Scattering, Radiation; Temperature; Thiazoles | 2007 |
Vitamin A potently destabilizes preformed alpha-synuclein fibrils in vitro: implications for Lewy body diseases.
Topics: alpha-Synuclein; Antioxidants; Benzothiazoles; beta Carotene; Coenzymes; Humans; Lewy Body Disease; Microscopy, Atomic Force; Microscopy, Electron; Microscopy, Fluorescence; Neurofibrils; Neuroprotective Agents; Parkinson Disease; Thiazoles; Ubiquinone; Vitamin A; Vitamins | 2007 |
Evidence for fibril-like structure in bovine casein micelles.
Topics: Animals; Benzothiazoles; Calcium Chloride; Caseins; Congo Red; Micelles; Microscopy, Electron, Transmission; Milk; Spectrometry, Fluorescence; Thiazoles | 2007 |
Identification of an amyloidogenic region on keratoepithelin via synthetic peptides.
Topics: Amino Acid Sequence; Amyloid; Benzothiazoles; Circular Dichroism; Congo Red; Extracellular Matrix Proteins; Fluorescence; Humans; Methylation; Molecular Sequence Data; Mutation; Peptides; Protein Structure, Secondary; Thiazoles; Transforming Growth Factor beta | 2007 |
A structural core within apolipoprotein C-II amyloid fibrils identified using hydrogen exchange and proteolysis.
Topics: Amino Acid Motifs; Amino Acid Sequence; Amyloid; Apolipoprotein C-II; Benzothiazoles; Chromatography, High Pressure Liquid; Circular Dichroism; Deuterium; Deuterium Exchange Measurement; Dose-Response Relationship, Drug; Electrophoresis, Agar Gel; Endopeptidase K; Fluorescent Dyes; Humans; Hydrogen; Hydrolysis; Kinetics; Mass Spectrometry; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Protein Conformation; Protein Folding; Protein Structure, Tertiary; Serine Endopeptidases; Spectrometry, Fluorescence; Thiazoles; Time Factors; Trypsin | 2007 |
Formation of amyloid-like fibrils by ovalbumin and related proteins under conditions relevant to food processing.
Topics: Amyloid; Benzothiazoles; Circular Dichroism; Food Handling; Ovalbumin; Protein Denaturation; Proteins; Serum Albumin, Bovine; Thiazoles; X-Ray Diffraction | 2007 |
Trehalose effects on alpha-crystallin aggregates.
Topics: alpha-Crystallins; Benzothiazoles; Circular Dichroism; Microscopy, Atomic Force; Protein Structure, Quaternary; Spectrometry, Fluorescence; Thiazoles; Trehalose | 2007 |
Bis-styrylpyridine and bis-styrylbenzene derivatives as inhibitors for Abeta fibril formation.
Topics: Amyloid beta-Peptides; Animals; Benzene Derivatives; Benzothiazoles; Cell Line; Cell Survival; Drug Design; Inhibitory Concentration 50; Mice; Pyridines; Structure-Activity Relationship; Styrenes; Thiazoles | 2007 |
Study on the binding of Thioflavin T to beta-sheet-rich and non-beta-sheet cavities.
Topics: Acetylcholinesterase; Amyloid; Benzothiazoles; Fluorescence; Fluorescent Dyes; gamma-Cyclodextrins; Humans; Ligands; Models, Molecular; Prealbumin; Protein Structure, Secondary; Thiazoles | 2007 |
Spider silk and amyloid fibrils: a structural comparison.
Topics: Amyloid; Animals; Benzothiazoles; Circular Dichroism; Congo Red; Fungal Proteins; Microscopy, Atomic Force; Peptide Termination Factors; Prions; Saccharomyces cerevisiae Proteins; Silk; Spectroscopy, Fourier Transform Infrared; Spiders; Thiazoles; X-Ray Diffraction | 2007 |
Spectral properties of thioflavin T in solvents with different dielectric properties and in a fibril-incorporated form.
Topics: Amyloid; Benzothiazoles; Fluorescence; Fluorescent Dyes; Quantum Theory; Solvents; Spectrometry, Fluorescence; Thiazoles | 2007 |
Aggregation of lysozyme and of poly(ethylene glycol)-modified lysozyme after adsorption to silica.
Topics: Adsorption; Benzothiazoles; Fluorescent Dyes; Kinetics; Muramidase; Polyethylene Glycols; Protein Folding; Protein Structure, Secondary; Silicon Dioxide; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Thiazoles; Tryptophan | 2007 |
Hsp40 interacts directly with the native state of the yeast prion protein Ure2 and inhibits formation of amyloid-like fibrils.
Topics: Amyloid; Benzothiazoles; Glutathione Peroxidase; Heat-Shock Proteins; HSP40 Heat-Shock Proteins; Humans; Kinetics; Microscopy, Atomic Force; Prions; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Surface Plasmon Resonance; Thiazoles | 2007 |
Thioflavin T and birefringence assays to determine the conversion of proteins into fibrils.
Topics: Benzothiazoles; Birefringence; Calibration; Centrifugation; Chemistry, Physical; Fluorescent Dyes; Kinetics; Microscopy, Fluorescence; Milk Proteins; Models, Statistical; Protein Conformation; Protein Structure, Secondary; Proteins; Thiazoles; Whey Proteins | 2007 |
Cystatin C reduces the in vitro formation of soluble Abeta1-42 oligomers and protofibrils.
Topics: Amyloid beta-Peptides; Animals; Benzothiazoles; Chromatography, Gel; Cystatin C; Cystatins; Electrophoresis, Polyacrylamide Gel; Immunoblotting; In Vitro Techniques; Microscopy, Electron, Transmission; Peptide Fragments; Protease Inhibitors; Protein Binding; Recombinant Proteins; Spectrometry, Fluorescence; Thiazoles | 2007 |
Alternative membrane protein conformations in alcohols.
Topics: 2-Propanol; Alcohols; Bacterial Proteins; Benzothiazoles; Buffers; Circular Dichroism; Escherichia coli Proteins; Fluorescent Dyes; Hydrophobic and Hydrophilic Interactions; Kinetics; Lipid Bilayers; Membrane Proteins; Microscopy, Atomic Force; Models, Chemical; Propanols; Protein Conformation; Protein Denaturation; Protein Structure, Secondary; Sodium-Hydrogen Exchangers; Solubility; Spectroscopy, Fourier Transform Infrared; Thiazoles; Trifluoroethanol; Water | 2007 |
Cloning and expression of human islet amyloid polypeptide in cultured cells.
Topics: Amyloid; Animals; Benzothiazoles; Cell Survival; Cells, Cultured; Chlorocebus aethiops; CHO Cells; Cloning, Molecular; COS Cells; Cricetinae; Cricetulus; Escherichia coli; Humans; Islet Amyloid Polypeptide; Microscopy, Atomic Force; Rats; Spectrometry, Fluorescence; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiazoles; Transfection | 2007 |
Preferential association of serum amyloid P component with fibrillar deposits in familial British and Danish dementias: similarities with Alzheimer's disease.
Topics: Adaptor Proteins, Signal Transducing; Aged; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Biomarkers; Brain; Cerebral Amyloid Angiopathy, Familial; Dementia; Denmark; England; Humans; Immunohistochemistry; Membrane Glycoproteins; Membrane Proteins; Neurofibrils; Peptide Fragments; Plaque, Amyloid; Protein Subunits; Serum Amyloid P-Component; Thiazoles | 2007 |
Role of a novel excipient poly(ethylene glycol)-b-poly(L-histidine) in retention of physical stability of insulin in aqueous solutions.
Topics: Anilino Naphthalenesulfonates; Benzothiazoles; Circular Dichroism; Drug Stability; Excipients; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Insulin; Kinetics; Particle Size; Polyethylene Glycols; Polyethylenes; Polypropylenes; Protein Binding; Protein Denaturation; Protein Structure, Secondary; Proteins; Radioimmunoassay; Recombinant Proteins; Solubility; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Thiazoles | 2007 |
Anti-fibrillogenic and fibril-destabilizing activity of nicotine in vitro: implications for the prevention and therapeutics of Lewy body diseases.
Topics: alpha-Synuclein; Benzothiazoles; Humans; Kinetics; Lewy Body Disease; Microfibrils; Microscopy, Atomic Force; Microscopy, Electron; Mutation; Nicotine; Nicotinic Agonists; Pyridines; Pyrrolidines; Reverse Transcriptase Polymerase Chain Reaction; Spectrometry, Fluorescence; Thiazoles | 2007 |
Consequential alterations in haemoglobin structure upon glycation with fructose: prevention by acetylsalicylic acid.
Topics: Anilino Naphthalenesulfonates; Animals; Aspirin; Benzothiazoles; Cattle; Circular Dichroism; Fluorescent Dyes; Fructose; Hemoglobins; Methemoglobin; Protein Binding; Protein Structure, Secondary; Thiazoles; Time Factors; Ultraviolet Rays | 2007 |
Effects of oxidation on the structure and stability of human low-density lipoprotein.
Topics: Amyloid; Apolipoproteins B; Benzothiazoles; Circular Dichroism; Copper; Drug Stability; Hot Temperature; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hypochlorous Acid; Lipoproteins, HDL; Lipoproteins, LDL; Oxidation-Reduction; Peroxidase; Protein Structure, Secondary; Spectrometry, Fluorescence; Thiazoles | 2007 |
Cyanine dye-protein interactions: looking for fluorescent probes for amyloid structures.
Topics: Amyloid; Animals; Benzothiazoles; Carbocyanines; Congo Red; Fluorescent Dyes; Humans; In Vitro Techniques; Lactoglobulins; Spectrometry, Fluorescence; Thiazoles | 2007 |
Mulberry leaf extract prevents amyloid beta-peptide fibril formation and neurotoxicity.
Topics: Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Count; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Hippocampus; Mice; Mice, Inbred ICR; Microscopy, Atomic Force; Morus; Neurofibrillary Tangles; Neurons; Neuroprotective Agents; Peptide Fragments; Plant Extracts; Thiazoles | 2007 |
High throughput screening for small molecule inhibitors of heparin-induced tau fibril formation.
Topics: Benzothiazoles; Drug Evaluation, Preclinical; Fluorescence; Fluorescent Dyes; Furans; Heparin; Neurofibrillary Tangles; Quinoxalines; Recombinant Proteins; Structure-Activity Relationship; tau Proteins; Thiazoles | 2007 |
Computational study of thioflavin T torsional relaxation in the excited state.
Topics: Benzothiazoles; Computer Simulation; Models, Chemical; Quantum Theory; Thiazoles | 2007 |
Kinetic refolding barrier of guanidinium chloride denatured goose delta-crystallin leads to regular aggregate formation.
Topics: Animals; Benzothiazoles; Birds; Chromatography, Gel; Circular Dichroism; Congo Red; delta-Crystallins; Dimerization; Electrophoresis, Polyacrylamide Gel; Guanidine; Kinetics; Microscopy, Electron, Transmission; Models, Molecular; Mutation; Protein Conformation; Protein Denaturation; Protein Folding; Protein Subunits; Thiazoles; Tryptophan | 2007 |
Cytotoxicity of insulin within its self-assembly and amyloidogenic pathways.
Topics: Amyloid; Animals; Benzothiazoles; Cattle; Insulin; Kinetics; Microscopy, Atomic Force; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2007 |
Glucagon amyloid-like fibril morphology is selected via morphology-dependent growth inhibition.
Topics: Amyloid; Benzothiazoles; Circular Dichroism; Fluorescent Dyes; Glucagon; In Vitro Techniques; Kinetics; Microscopy, Electron; Models, Molecular; Multiprotein Complexes; Osmolar Concentration; Protein Conformation; Protein Structure, Quaternary; Thiazoles | 2007 |
Analytical method for beta-amyloid fibrils using CE-laser induced fluorescence and its application to screening for inhibitors of beta-amyloid protein aggregation.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Benzothiazoles; Daunorubicin; Fluorescence; Fluorescent Dyes; Humans; Indoles; Lasers; Mass Screening; Melatonin; Molecular Sequence Data; Propionates; Sensitivity and Specificity; Thiazoles; Time Factors | 2007 |
Formation of toxic fibrils of Alzheimer's amyloid beta-protein-(1-40) by monosialoganglioside GM1, a neuronal membrane component.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Membrane; Chromatography, Gel; Circular Dichroism; G(M1) Ganglioside; Microscopy, Electron, Transmission; Neurons; PC12 Cells; Peptide Fragments; Protein Structure, Secondary; Rats; Thiazoles | 2007 |
Thioflavin T fluorescence anisotropy: an alternative technique for the study of amyloid aggregation.
Topics: Amyloid; Anisotropy; Benzothiazoles; Dimerization; Fungal Proteins; Spectrometry, Fluorescence; Thiazoles | 2007 |
Conformational properties of aggregated polypeptides determine ClpB-dependence in the disaggregation process.
Topics: Benzothiazoles; Circular Dichroism; Endopeptidase Clp; Escherichia coli; Escherichia coli Proteins; Guanidine; Heat-Shock Proteins; Luciferases; Peptides; Protein Denaturation; Protein Structure, Quaternary; Protein Structure, Secondary; Thiazoles | 2007 |
Novel method for quantitative determination of amyloid fibrils of alpha-synuclein and amyloid beta/A4 protein by using resveratrol.
Topics: alpha-Synuclein; Amyloid; Amyloid beta-Peptides; Amyloidosis; Benzothiazoles; Humans; Protein Structure, Quaternary; Resveratrol; Spectrometry, Fluorescence; Stilbenes; Thiazoles | 2007 |
The active site cysteine of the proapoptotic protein glyceraldehyde-3-phosphate dehydrogenase is essential in oxidative stress-induced aggregation and cell death.
Topics: Amino Acid Substitution; Amyloid; Animals; Apoptosis Regulatory Proteins; Benzothiazoles; Binding Sites; Cell Death; Cysteine; Glyceraldehyde-3-Phosphate Dehydrogenases; HeLa Cells; Humans; Mutation, Missense; Neurons; Oxidants; Oxidation-Reduction; Oxidative Stress; Protein Structure, Secondary; Rabbits; Thiazoles | 2007 |
Hyper-homocysteinemia alters amyloid peptide-clusterin interactions and neuroglial network morphology and function in the caudate after intrastriatal injection of amyloid peptides.
Topics: Amyloid beta-Peptides; Animals; Behavior, Animal; Benzothiazoles; Caudate Nucleus; Clusterin; Drug Interactions; Food, Formulated; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Models, Biological; Pain Measurement; Peptide Fragments; Rats; Rats, Sprague-Dawley; Reaction Time; Thiazoles | 2007 |
Evaluation of different culture conditions for high-level soluble expression of human cyclin A2 with pET vector in BL21 (DE3) and spectroscopic characterization of its inclusion body structure.
Topics: Benzothiazoles; Chromatography, Affinity; Culture Media; Cyclin A; Cyclin A2; Escherichia coli; Genetic Vectors; Humans; Inclusion Bodies; Rifampin; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2007 |
Mapping the structural transition in an amyloidogenic apolipoprotein A-I.
Topics: Apolipoprotein A-I; Benzothiazoles; Circular Dichroism; Electron Spin Resonance Spectroscopy; Humans; Models, Molecular; Peptide Fragments; Phospholipids; Protein Conformation; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2007 |
Surface structure of amyloid-beta fibrils contributes to cytotoxicity.
Topics: Acetylation; Amyloid beta-Peptides; Animals; Benzothiazoles; Carrier Proteins; Cattle; Cell Survival; Cells, Cultured; Fluorescence; Humans; Kidney; Maltose-Binding Proteins; Microscopy, Electron, Transmission; Peptide Fragments; Plaque, Amyloid; Thiazoles; Tryptophan | 2007 |
Conversion of non-fibrillar beta-sheet oligomers into amyloid fibrils in Alzheimer's disease amyloid peptide aggregation.
Topics: Amyloid beta-Peptides; Benzothiazoles; Fluorescent Dyes; Kinetics; Microscopy, Electron, Transmission; Peptide Fragments; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2007 |
The role of the VQIVYK peptide in tau protein phosphorylation.
Topics: Animals; Benzothiazoles; Chlorocebus aethiops; COS Cells; Humans; Peptide Fragments; Phosphorylation; Sequence Deletion; tau Proteins; Thiazoles; Up-Regulation | 2007 |
Binding mode of Thioflavin T in insulin amyloid fibrils.
Topics: Amyloid; Benzothiazoles; Calorimetry; Fluorescence; Humans; Insulin; Protein Binding; Protein Conformation; Thiazoles; X-Ray Diffraction | 2007 |
Phenylthiazolyl-hydrazide and its derivatives are potent inhibitors of tau aggregation and toxicity in vitro and in cells.
Topics: Animals; Benzothiazoles; Binding Sites; Cell Line, Tumor; Cell Survival; Drug Evaluation, Preclinical; Humans; Hydrazines; Hydro-Lyases; Ligands; Models, Biological; Models, Chemical; Neurofibrillary Tangles; Protein Binding; Protein Denaturation; Protein Structure, Tertiary; tau Proteins; Tauopathies; Thiazoles | 2007 |
Aggregation and fibrillation of bovine serum albumin.
Topics: Amyloid; Animals; Benzothiazoles; Cattle; Cell Survival; Congo Red; Neuroblastoma; Protein Structure, Secondary; Serum Albumin, Bovine; Spectroscopy, Fourier Transform Infrared; Thiazoles; Trypsin; Tumor Cells, Cultured; X-Ray Diffraction | 2007 |
TgCRND8 amyloid precursor protein transgenic mice exhibit an altered gamma-secretase processing and an aggressive, additive amyloid pathology subject to immunotherapeutic modulation.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Benzothiazoles; Brain; Chromatography, High Pressure Liquid; Immunotherapy; Mice; Mice, Transgenic; Molecular Sequence Data; Plaque, Amyloid; Protein Processing, Post-Translational; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiazoles | 2007 |
Soluble oligomers from a non-disease related protein mimic Abeta-induced tau hyperphosphorylation and neurodegeneration.
Topics: Amyloid beta-Peptides; Animals; Benzothiazoles; Blotting, Western; Cell Survival; Chickens; Chromatography, Gel; Circular Dichroism; Electrophoresis, Polyacrylamide Gel; Epitopes; Female; Fluorescent Antibody Technique; Fluorescent Dyes; Microscopy, Electron; Muramidase; Nephelometry and Turbidimetry; Nerve Degeneration; Neurons; Phosphorylation; Pregnancy; Rats; Rats, Sprague-Dawley; Rats, Wistar; tau Proteins; Thiazoles | 2007 |
Differentiating Alzheimer disease-associated aggregates with small molecules.
Topics: alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Dose-Response Relationship, Drug; Fluorescent Dyes; Humans; Mass Spectrometry; Neurofibrillary Tangles; Peptide Library; Plaque, Amyloid; tau Proteins; Thiazines; Thiazoles | 2007 |
Promotion of insulin aggregation by protein disulfide isomerase.
Topics: Animals; Benzothiazoles; Cattle; Chemical Precipitation; Congo Red; Disulfides; Insulin; Oxidation-Reduction; Protein Binding; Protein Disulfide-Isomerases; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2007 |
Thioflavin derivatives as markers for amyloid-beta fibrils: insights into structural features important for high-affinity binding.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Binding Sites; Biomarkers; Heterocyclic Compounds; Peptides; Protein Structure, Tertiary; Structure-Activity Relationship; Thiazoles | 2008 |
Influence of phosphorus dendrimers on the aggregation of the prion peptide PrP 185-208.
Topics: Amino Acid Sequence; Amyloid; Benzothiazoles; Dendrimers; Microscopy, Electron; Molecular Sequence Data; Peptide Fragments; Phosphorus; Prions; Protein Structure, Secondary; PrPC Proteins; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2007 |
Sequence Determinants for Amyloid Fibrillogenesis of Human alpha-Synuclein.
Topics: alpha-Synuclein; Amino Acid Sequence; Amyloid; Benzothiazoles; beta-Synuclein; Fluorescence; Humans; Molecular Sequence Data; Mutation; Protein Conformation; Protein Folding; Sequence Deletion; Sequence Homology, Amino Acid; Thiazoles | 2007 |
Optimization of a polyglutamine aggregation inhibitor peptide (QBP1) using a thioflavin T fluorescence assay.
Topics: Algorithms; Benzothiazoles; Congo Red; Dose-Response Relationship, Drug; Fluorescent Dyes; Indicators and Reagents; Microscopy, Fluorescence; Oligopeptides; Peptides; Protein Conformation; Recombinant Fusion Proteins; Thiazoles | 2007 |
Design of mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and new structural templates.
Topics: Amyloidosis; Benzamides; Benzothiazoles; Cell Line; Cell Survival; Cross-Linking Reagents; Drug Design; Fluorescence; Glutaral; Humans; Kinetics; Models, Molecular; Oxadiazoles; Phenyl Ethers; Prealbumin; Protein Denaturation; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Structure-Activity Relationship; Thiazoles; Triazoles; Tryptophan | 2007 |
Congo red and thioflavin-T analogs detect Abeta oligomers.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Cell Line, Tumor; Coloring Agents; Congo Red; Fluorescent Dyes; Hippocampus; Humans; Microscopy, Electron, Transmission; Neuroblastoma; Surface Plasmon Resonance; Thiazoles | 2008 |
Abeta 1-42 induces mild endoplasmic reticulum stress in an aggregation state-dependent manner.
Topics: Amyloid beta-Peptides; Benzothiazoles; Calnexin; Cell Differentiation; Cell Line; Cell Survival; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Fluorescent Dyes; Formazans; Humans; In Situ Nick-End Labeling; Neuroblastoma; Peptide Fragments; Protein Conformation; Stress, Physiological; Temperature; Tetrazolium Salts; Thiazoles; Time Factors; Transfection; Tunicamycin | 2007 |
Amyloid adhesins are abundant in natural biofilms.
Topics: Actinobacteria; Adhesins, Bacterial; Amyloid; Bacteria; Benzothiazoles; Biofilms; DNA, Bacterial; Fluorescent Dyes; Molecular Sequence Data; Proteobacteria; RNA, Ribosomal, 16S; Seawater; Sequence Analysis, DNA; Sewage; Thiazoles; Water Supply | 2007 |
Monitoring the prevention of amyloid fibril formation by alpha-crystallin. Temperature dependence and the nature of the aggregating species.
Topics: alpha-Crystallin B Chain; alpha-Synuclein; Amyloid; Animals; Benzothiazoles; beta-Crystallins; Caseins; Cattle; Chromatography, High Pressure Liquid; Humans; Kinetics; Magnetic Resonance Spectroscopy; Microscopy, Electron, Transmission; Molecular Chaperones; Protein Binding; Recombinant Proteins; Temperature; Thiazoles | 2007 |
Phospholipid interaction induces molecular-level polymorphism in apolipoprotein C-II amyloid fibrils via alternative assembly pathways.
Topics: Amyloid; Apolipoprotein C-II; Benzothiazoles; Buffers; Circular Dichroism; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Kinetics; Micelles; Models, Chemical; Models, Molecular; Osmolar Concentration; Phosphates; Phospholipids; Polymorphism, Genetic; Protein Conformation; Protein Structure, Secondary; Solubility; Solutions; Temperature; Thiazoles; Unilamellar Liposomes; Water | 2008 |
Accelerated release of exosome-associated GM1 ganglioside (GM1) by endocytic pathway abnormality: another putative pathway for GM1-induced amyloid fibril formation.
Topics: Amyloid beta-Peptides; Animals; Benzothiazoles; Calcium; Cell Fractionation; Chloroquine; Endocytosis; G(M1) Ganglioside; Membrane Microdomains; Microscopy, Electron, Scanning; Models, Biological; PC12 Cells; Potassium Chloride; Protein Transport; Rats; Thiazoles | 2008 |
Anti-amyloidogenic activity of S-allyl-L-cysteine and its activity to destabilize Alzheimer's beta-amyloid fibrils in vitro.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Benzothiazoles; Cysteine; Humans; Macromolecular Substances; Microscopy, Electron, Transmission; Neuroprotective Agents; Protein Binding; Protein Conformation; Protein Folding; Thiazoles | 2007 |
Amyloid toxicity is independent of polypeptide sequence, length and chirality.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Membrane; Cells, Cultured; Circular Dichroism; Cystatin C; Cystatins; Formazans; Hippocampus; Humans; Kinetics; Mass Spectrometry; Molecular Weight; Neurons; PC12 Cells; Peptide Fragments; Peptides; Prions; Protein Structure, Quaternary; Protein Structure, Secondary; Rats; Sonication; Synapses; tau Proteins; Tetrazolium Salts; Thiazoles | 2008 |
Apoptotic death induces Abeta production and fibril formation to a much larger extent than necrotic-like death in CGNs.
Topics: Aged; Alzheimer Disease; Amyloid beta-Protein Precursor; Apoptosis; Benzothiazoles; Cerebellum; DNA Fragmentation; Enzyme-Linked Immunosorbent Assay; Fluorescent Dyes; Humans; Huntington Disease; Membrane Proteins; Microfilament Proteins; Microscopy, Electron, Transmission; Necrosis; Parkinson Disease; Reticulin; Thiazoles | 2007 |
Evidence of fibril-like β-sheet structures in a neurotoxic amyloid intermediate of Alzheimer's β-amyloid.
Topics: Amyloid; Amyloid beta-Peptides; Animals; Benzothiazoles; Fluorescent Dyes; Humans; Microscopy, Fluorescence; Models, Chemical; Neurotoxins; PC12 Cells; Peptide Fragments; Protein Folding; Protein Structure, Secondary; Rats; Thiazoles | 2007 |
Prion detection by an amyloid seeding assay.
Topics: Amyloid; Animals; Benzothiazoles; Brain; Creutzfeldt-Jakob Syndrome; Cricetinae; Humans; Kinetics; Mesocricetus; Mice; Peptide Hydrolases; Polymers; Prions; Protein Folding; Recombinant Proteins; Spectrometry, Fluorescence; Thiazoles | 2007 |
The (1-63) region of the p53 transactivation domain aggregates in vitro into cytotoxic amyloid assemblies.
Topics: Amyloid; Benzothiazoles; Cell Line, Tumor; Cell Survival; Cytotoxins; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Microscopy, Atomic Force; Peptide Fragments; Protein Binding; Protein Structure, Tertiary; Spectroscopy, Fourier Transform Infrared; Thiazoles; Tumor Suppressor Protein p53; X-Ray Diffraction | 2008 |
Unfolding and aggregation of transthyretin by the truncation of 50 N-terminal amino acids.
Topics: Amino Acids; Benzothiazoles; Chromatography, Gel; Circular Dichroism; Fluorescence; Microscopy, Atomic Force; Mutant Proteins; Prealbumin; Protein Folding; Protein Structure, Quaternary; Protein Structure, Secondary; Sequence Analysis, Protein; Sequence Deletion; Thiazoles; Time Factors | 2008 |
Inhibition of LTP in vivo by beta-amyloid peptide in different conformational states.
Topics: Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Congo Red; Injections, Intraventricular; Long-Term Potentiation; Male; Microscopy, Electron, Transmission; Peptide Fragments; Protein Structure, Secondary; Rats; Rats, Wistar; Synaptic Transmission; Thiazoles | 2008 |
Dissociation from the oligomeric state is the rate-limiting step in fibril formation by kappa-casein.
Topics: Amyloid; Animals; Benzothiazoles; Caseins; Cattle; Endopeptidase K; Mass Spectrometry; Models, Chemical; Nephelometry and Turbidimetry; Spectrometry, Fluorescence; Thiazoles; Trypsin | 2008 |
Mixed macromolecular crowding inhibits amyloid formation of hen egg white lysozyme.
Topics: Amyloid; Animals; Benzothiazoles; Cattle; Ficoll; Microscopy, Electron, Transmission; Muramidase; Serum Albumin, Bovine; Thiazoles | 2008 |
Inhibition of cytotoxicity and amyloid fibril formation by a D-amino acid peptide that specifically binds to Alzheimer's disease amyloid peptide.
Topics: Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Death; Cytotoxins; Microscopy, Electron; PC12 Cells; Peptides; Polymers; Protein Binding; Protein Structure, Secondary; Rats; Spectrometry, Fluorescence; Substrate Specificity; Thiazoles | 2008 |
Amyloid-like fibrils in elastin-related polypeptides: structural characterization and elastic properties.
Topics: Amino Acid Sequence; Amyloid; Benzothiazoles; Circular Dichroism; Congo Red; Elastin; Fluorescent Dyes; Humans; Microscopy, Atomic Force; Nanotechnology; Protein Structure, Secondary; Proteins; Spectroscopy, Fourier Transform Infrared; Stress, Mechanical; Thiazoles | 2008 |
Single particle characterization of iron-induced pore-forming alpha-synuclein oligomers.
Topics: alpha-Synuclein; Benzothiazoles; Electrophysiology; Flavanones; Fluorescent Dyes; Gene Expression Regulation; Humans; Iron; Lipid Bilayers; Microscopy, Atomic Force; Microscopy, Confocal; Models, Biological; Parkinson Disease; Protein Binding; Solvents; Thiazoles | 2008 |
Ligand-induced flocculation of neurotoxic fibrillar Abeta(1-42) by noncovalent crosslinking.
Topics: Amyloid beta-Peptides; Benzothiazoles; Binding Sites; Flocculation; Ligands; Magnetic Resonance Spectroscopy; Microscopy, Electron, Transmission; Particle Size; Peptide Fragments; Peptides; Reference Standards; Surface Properties; Thiazoles; Time Factors | 2008 |
Amyloid fibril formation by bovine milk alpha s2-casein occurs under physiological conditions yet is prevented by its natural counterpart, alpha s1-casein.
Topics: Amyloid; Animals; Benzothiazoles; Caseins; Cattle; Chromatography, Ion Exchange; Circular Dichroism; Female; Hydrogen-Ion Concentration; Microscopy, Electron, Transmission; Oxidation-Reduction; Temperature; Thiazoles; Ultraviolet Rays; X-Ray Diffraction | 2008 |
Cu(II) organizes beta-2-microglobulin oligomers but is released upon amyloid formation.
Topics: Amyloid; Benzothiazoles; beta 2-Microglobulin; Chromatography, Gel; Copper Sulfate; Electron Probe Microanalysis; Humans; Light; Mass Spectrometry; Microscopy, Electron, Transmission; Models, Biological; Protein Structure, Quaternary; Scattering, Radiation; Spectrometry, Fluorescence; Thiazoles | 2008 |
The formation of a novel supramolecular structure by amyloid of poly-L-glutamic acid.
Topics: Amyloid; Benzothiazoles; Fluorescent Dyes; Hydrogen-Ion Concentration; Kinetics; Microscopy, Electron, Scanning; Molecular Structure; Polyglutamic Acid; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2008 |
Secondary nucleation and accessible surface in insulin amyloid fibril formation.
Topics: Amyloid; Benzothiazoles; Humans; Insulin; Kinetics; Surface Properties; Thiazoles | 2008 |
A multimeric quinacrine conjugate as a potential inhibitor of Alzheimer's beta-amyloid fibril formation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Dose-Response Relationship, Drug; Drug Design; Microscopy, Atomic Force; Protein Binding; Quinacrine; Spectrometry, Fluorescence; Thiazoles | 2008 |
The degree of structural protection at the edge beta-strands determines the pathway of amyloid formation in globular proteins.
Topics: Acid Anhydride Hydrolases; Acylphosphatase; Amyloid; Benzothiazoles; Enzyme Activation; Kinetics; Point Mutation; Protein Conformation; Protein Folding; Protein Structure, Secondary; Sulfolobus solfataricus; Thiazoles; Time Factors | 2008 |
Abeta peptide conformation determines uptake and interleukin-1alpha expression by primary microglial cells.
Topics: Amyloid beta-Peptides; Analysis of Variance; Animals; Animals, Newborn; Benzothiazoles; Cells, Cultured; Cerebral Cortex; Cytokines; Dose-Response Relationship, Drug; Gene Expression Regulation; Interleukin-1alpha; L-Lactate Dehydrogenase; Magnetic Resonance Imaging; Mice; Microglia; Microscopy, Electron, Transmission; Neuroblastoma; Peptide Fragments; Protein Conformation; Thiazoles | 2009 |
Acridine derivatives inhibit lysozyme aggregation.
Topics: Acridines; Amyloid; Animals; Benzothiazoles; Dose-Response Relationship, Drug; Enzyme Inhibitors; Molecular Weight; Muramidase; Protein Binding; Small Molecule Libraries; Thiazoles; Time Factors | 2008 |
Formation of amyloid fibrils by bovine carbonic anhydrase.
Topics: Amyloid; Animals; Benzothiazoles; Carbonic Anhydrase II; Cattle; Circular Dichroism; Congo Red; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Models, Biological; Protein Folding; Thiazoles | 2008 |
On the binding of Thioflavin-T to HET-s amyloid fibrils assembled at pH 2.
Topics: Amyloid; Benzothiazoles; Fluorescent Dyes; Fungal Proteins; Humans; Hydrogen-Ion Concentration; Insulin; Kinetics; Podospora; Polymers; Prions; Protein Binding; Protein Structure, Secondary; Static Electricity; Thiazoles | 2008 |
Role of trehalose in moisture-induced aggregation of bovine serum albumin.
Topics: Benzothiazoles; Congo Red; Drug Stability; Drug Storage; Electrophoresis, Polyacrylamide Gel; Excipients; Fluorescent Dyes; Humidity; Protein Denaturation; Serum Albumin, Bovine; Spectrometry, Fluorescence; Thiazoles; Trehalose; Tryptophan | 2008 |
[Estimating of changes in the amyloid and prion content of yeast cells].
Topics: Amyloid; Benzothiazoles; Crosses, Genetic; Guanidine; Peptide Termination Factors; Prions; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Staining and Labeling; Thiazoles | 2008 |
Alpha-synuclein aggregation and cell death triggered by energy deprivation and dopamine overload are counteracted by D2/D3 receptor activation.
Topics: alpha-Synuclein; Analysis of Variance; Animals; Benzothiazoles; Cell Death; Cells, Cultured; Dopamine; Dopamine Agents; Dopamine Plasma Membrane Transport Proteins; Embryo, Mammalian; Formazans; Gene Expression Regulation; Glucose; Mesencephalon; Mice; Mitochondria; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Protein Transport; Receptors, Dopamine D2; Tetrazolium Salts; Thiazoles | 2008 |
Altered binding of thioflavin t to the peripheral anionic site of acetylcholinesterase after phosphorylation of the active site by chlorpyrifos oxon or dichlorvos.
Topics: Acetylcholinesterase; Benzothiazoles; Binding Sites; Chlorpyrifos; Cholinesterase Inhibitors; Dichlorvos; Insecticides; Phosphorylation; Thiazoles | 2008 |
Chiral bifurcation in aggregating insulin: an induced circular dichroism study.
Topics: Amyloid; Animals; Benzothiazoles; Cattle; Circular Dichroism; Congo Red; Insulin; Protein Folding; Protein Structure, Secondary; Temperature; Thiazoles | 2008 |
Rifampicin does not prevent amyloid fibril formation by human islet amyloid polypeptide but does inhibit fibril thioflavin-T interactions: implications for mechanistic studies of beta-cell death.
Topics: Amyloid; Antioxidants; Benzothiazoles; Cell Death; Humans; Islet Amyloid Polypeptide; Islets of Langerhans; Microscopy, Electron, Transmission; Rifampin; Thiazoles | 2008 |
The flexible C terminus of the rotavirus non-structural protein NSP4 is an important determinant of its biological properties.
Topics: Amino Acid Sequence; Animals; Animals, Suckling; Benzothiazoles; Cell Line; Glycoproteins; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Point Mutation; Protein Conformation; Receptors, Virus; Rotavirus; Rotavirus Infections; Thiazoles; Toxins, Biological; Trypsin; Viral Nonstructural Proteins; Virulence | 2008 |
The fluorescent amino acid p-cyanophenylalanine provides an intrinsic probe of amyloid formation.
Topics: Alanine; Amino Acid Sequence; Amyloid; Benzothiazoles; Diabetes Mellitus, Type 2; Fluorescence; Fluorescent Dyes; Humans; Islet Amyloid Polypeptide; Kinetics; Molecular Sequence Data; Nitriles; Phenylalanine; Point Mutation; Protein Binding; Thiazoles; Time Factors | 2008 |
Posterior parahippocampal gyrus pathology in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Cerebral Cortex; Female; Humans; Immunohistochemistry; Male; Neurofibrillary Tangles; Neurofilament Proteins; Parahippocampal Gyrus; Parvalbumins; Thiazoles | 2008 |
Molecular understanding of copper and iron interaction with alpha-synuclein by fluorescence analysis.
Topics: alpha-Synuclein; Anilino Naphthalenesulfonates; Benzothiazoles; Binding Sites; Copper; Fluorescence; Fluorescent Dyes; Humans; Iron; Protein Binding; Thiazoles; Tyrosine | 2008 |
Dimorphic aggregation behavior of a fusion polypeptide incorporating a stable protein domain (EGFP) with an amyloidogenic sequence (retroCspA).
Topics: Amyloid; Benzothiazoles; Cold Shock Proteins and Peptides; Escherichia coli Proteins; Green Fluorescent Proteins; Heat-Shock Proteins; Molecular Weight; Protein Biosynthesis; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Fusion Proteins; Thiazoles | 2008 |
Thioflavin T displays enhanced fluorescence selectively inside anionic micelles and mammalian cells.
Topics: Amyloid; Animals; Benzothiazoles; Cell Line; Cell Membrane; Chickens; Cricetinae; Egg White; Fluorescence; Fluorescent Dyes; HT29 Cells; Humans; Micelles; Microscopy, Fluorescence; Muramidase; Octoxynol; Polysorbates; Sodium Dodecyl Sulfate; Surface-Active Agents; Thiazoles; Water | 2008 |
Crystal structure of thioflavin T bound to the peripheral site of Torpedo californica acetylcholinesterase reveals how thioflavin T acts as a sensitive fluorescent reporter of ligand binding to the acylation site.
Topics: Acetylcholinesterase; Acylation; Animals; Benzothiazoles; Binding Sites; Crystallography, X-Ray; Fluorescent Dyes; Humans; Ligands; Models, Molecular; Molecular Structure; Thiazoles; Torpedo | 2008 |
Contrasting in vivo effects of two peptide-based amyloid-beta protein aggregation inhibitors in a transgenic mouse model of amyloid deposition.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Disease Models, Animal; Hippocampus; Humans; Mice; Mice, Transgenic; Microglia; Molecular Structure; Peptides; Plaque, Amyloid; Thiazoles | 2008 |
Water-soluble tripeptide Abeta (9-11) forms amyloid-like fibrils and exhibits neurotoxicity.
Topics: Amyloid; Animals; Benzothiazoles; Cell Line; Cell Survival; Microscopy, Electron, Transmission; Molecular Structure; Neurons; Oligopeptides; Solubility; Thiazoles; Water | 2008 |
Characterization of amyloidogenesis of hen egg lysozyme in concentrated ethanol solution.
Topics: Amino Acids; Amyloid; Animals; Benzothiazoles; Circular Dichroism; Ethanol; Microscopy, Atomic Force; Muramidase; Solutions; Thiazoles | 2008 |
Thermally induced denaturation and aggregation of BLG-A: effect of the Cu(2+) and Zn (2+) metal ions.
Topics: Amyloid; Benzothiazoles; Calorimetry, Differential Scanning; Cations, Divalent; Copper; Electron Spin Resonance Spectroscopy; Lactoglobulins; Nephelometry and Turbidimetry; Protein Binding; Protein Conformation; Protein Denaturation; Protein Stability; Spectrometry, Fluorescence; Temperature; Thiazoles; Tryptophan; Zinc | 2008 |
Effects of amyloid-beta peptides on hydrogen peroxide-metabolizing enzymes in rat brain in vivo.
Topics: Amyloid beta-Peptides; Animals; Antioxidants; Benzothiazoles; Brain; Cytosol; Hydrogen Peroxide; Male; Mitochondria; Models, Biological; Neurodegenerative Diseases; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Thiazoles | 2008 |
Corticosterone and related receptor expression are associated with increased beta-amyloid plaques in isolated Tg2576 mice.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Benzothiazoles; Corticosterone; Disease Models, Animal; Hippocampus; Humans; Mice; Mice, Transgenic; Mutation; Plaque, Amyloid; Receptors, Corticotropin-Releasing Hormone; Receptors, Glucocorticoid; Stress, Psychological; Thiazoles | 2008 |
Lipid-derived aldehydes accelerate light chain amyloid and amorphous aggregation.
Topics: Aldehydes; Benzothiazoles; Cholesterol; Congo Red; Glyoxal; Humans; Immunoglobulin Light Chains; Lipids; Malondialdehyde; Protein Denaturation; Thiazoles | 2008 |
Beta-lactoglobulin assembles into amyloid through sequential aggregated intermediates.
Topics: Amyloid; Anilino Naphthalenesulfonates; Animals; Benzothiazoles; Binding Sites; Cattle; Fluorescence; Hydrophobic and Hydrophilic Interactions; Lactoglobulins; Light; Microscopy, Atomic Force; Protein Structure, Quaternary; Protein Structure, Secondary; Scattering, Radiation; Thiazoles | 2008 |
Tg-SwDI transgenic mice exhibit novel alterations in AbetaPP processing, Abeta degradation, and resilient amyloid angiopathy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Apolipoproteins E; Benzothiazoles; Cerebral Amyloid Angiopathy; Dimerization; Disease Models, Animal; Humans; Mice; Mice, Transgenic; Plaque, Amyloid; Protein Conformation; Thiazoles | 2008 |
Monitoring the reaction of carbachol with acetylcholinesterase by thioflavin T fluorescence and acetylthiocholine hydrolysis.
Topics: Acetylcholinesterase; Acetylthiocholine; Benzothiazoles; Carbachol; Humans; Hydrolysis; Recombinant Proteins; Spectrometry, Fluorescence; Thiazoles | 2008 |
Different inhibitory response of cyanidin and methylene blue for filament formation of tau microtubule-binding domain.
Topics: Alzheimer Disease; Anthocyanins; Benzothiazoles; Cells, Cultured; Fluorescence; Fluorescent Dyes; Heparin; Humans; Methylene Blue; Microtubules; Protein Structure, Tertiary; tau Proteins; Thiazoles | 2008 |
Molecular polymorphism of Abeta in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Benzothiazoles; Binding Sites; Binding, Competitive; Coloring Agents; Congo Red; Diagnostic Imaging; Disease Models, Animal; Humans; Ligands; Molecular Probes; Pathology, Molecular; Plaque, Amyloid; Predictive Value of Tests; Protein Isoforms; Thiazoles | 2010 |
The mechanism of amyloid-fibril formation by stefin B: temperature and protein concentration dependence of the rates.
Topics: Amyloid; Benzothiazoles; Circular Dichroism; Cystatin B; Humans; Kinetics; Spectrometry, Fluorescence; Temperature; Thiazoles | 2009 |
Intracranial administration of vaccinia virus complement control protein in Mo/Hu APPswe PS1dE9 transgenic mice at an early age shows enhanced performance at a later age using a cheese board maze test.
Topics: Age Factors; Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloidosis; Animals; Association Learning; Behavior, Animal; Benzothiazoles; Complement System Proteins; Conditioning, Psychological; Disease Models, Animal; Genotype; Injections; Maze Learning; Mice; Mice, Transgenic; Reversal Learning; Space Perception; Thiazoles; Viral Proteins | 2008 |
Transthyretin protects against A-beta peptide toxicity by proteolytic cleavage of the peptide: a mechanism sensitive to the Kunitz protease inhibitor.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aprotinin; Benzothiazoles; Humans; Microscopy, Electron; Prealbumin; Recombinant Proteins; Thiazoles | 2008 |
The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Line; Humans; Microscopy, Electron, Transmission; Models, Biological; Neurons; Peptide Fragments; Peptides; Polymers; Protein Binding; Rats; Thiazoles; Time Factors | 2008 |
Role of conformational change in the C-terminus of beta2-microglobulin in dialysis-related amyloidosis.
Topics: Amyloidosis; Benzothiazoles; beta 2-Microglobulin; Dialysis; Humans; Hydrogen-Ion Concentration; Microscopy, Electron; Mutation; Protein Conformation; Protein Isoforms; Protein Structure, Tertiary; Recombinant Proteins; Spectrometry, Fluorescence; Thiazoles; Tryptophan; Ultrasonics | 2008 |
Strain-specific sequences required for yeast [PSI+] prion propagation.
Topics: Amino Acid Sequence; Benzothiazoles; Glycine; Peptide Termination Factors; Prions; Proline; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Thiazoles | 2008 |
Aggregation and conformational studies on a pentapeptide derivative.
Topics: Amyloid; Benzothiazoles; Hydrophobic and Hydrophilic Interactions; Isoleucine; Light; Oligopeptides; Polymers; Protein Binding; Protein Conformation; Protein Structure, Secondary; Scattering, Radiation; Solvents; Spectrum Analysis; Thiazoles; Water | 2008 |
Beta-amyloid deposition and functional impairment in the retina of the APPswe/PS1DeltaE9 transgenic mouse model of Alzheimer's disease.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antigens, Differentiation; Benzothiazoles; Choline O-Acetyltransferase; Disease Models, Animal; Electroretinography; Female; Fluorescent Antibody Technique, Indirect; Fluorescent Dyes; Glial Fibrillary Acidic Protein; Gliosis; Male; Mice; Mice, Transgenic; Microscopy, Confocal; Presenilin-1; Retina; Retinal Diseases; Syntaxin 1; Thiazoles | 2009 |
Aminostyrylbenzofuran derivatives as potent inhibitors for Abeta fibril formation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzofurans; Benzothiazoles; Benzoxazoles; Chemistry, Pharmaceutical; Curcumin; Drug Design; Electrons; Humans; Inhibitory Concentration 50; Models, Chemical; Peptide Fragments; Structure-Activity Relationship; Styrenes; Thiazoles | 2008 |
Cyanidin 3-O-glucopyranoside protects and rescues SH-SY5Y cells against amyloid-beta peptide-induced toxicity.
Topics: Amyloid beta-Peptides; Anthocyanins; Apoptosis; Benzothiazoles; Cell Death; Cell Line, Tumor; Drug Evaluation, Preclinical; Glucosides; Humans; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Neurons; Neuroprotective Agents; Peptide Fragments; Thiazoles | 2008 |
Thiazin red as a neuropathological tool for the rapid diagnosis of Alzheimer's disease in tissue imprints.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Brain; Female; Fluorescent Antibody Technique; Humans; Immunohistochemistry; Male; Microscopy, Confocal; Middle Aged; Neurofibrillary Tangles; Neurons; Organic Chemicals; Plaque, Amyloid; Postmortem Changes; Silver Staining; tau Proteins; Thiazoles | 2008 |
Proteolysis of prion protein by cathepsin S generates a soluble beta-structured intermediate oligomeric form, with potential implications for neurotoxic mechanisms.
Topics: Animals; Benzothiazoles; Cathepsins; Circular Dichroism; Hydrolysis; Neurotoxins; Peptide Fragments; Prion Diseases; Prions; Protein Conformation; Protein Folding; Protein Multimerization; Sequence Deletion; Sheep; Thiazoles | 2009 |
Effects of grape seed-derived polyphenols on amyloid beta-protein self-assembly and cytotoxicity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Flavonoids; Humans; Kinetics; L-Lactate Dehydrogenase; Microscopy, Electron; Models, Chemical; Molecular Conformation; Peptide Fragments; Peptides; Phenols; Polyphenols; Protein Conformation; Protein Isoforms; Protein Structure, Secondary; Thiazoles | 2008 |
Persisting atypical and cystic forms of Borrelia burgdorferi and local inflammation in Lyme neuroborreliosis.
Topics: Aged; Aged, 80 and over; Animals; Astrocytes; Benzothiazoles; Borrelia burgdorferi; Brain; Cells, Cultured; Chick Embryo; Coloring Agents; Congo Red; Fluorescent Dyes; Humans; In Situ Nick-End Labeling; Inflammation; Lyme Neuroborreliosis; Microscopy, Atomic Force; Neurons; Rats; Thiazoles | 2008 |
Sulfated polysaccharides promote the assembly of amyloid beta(1-42) peptide into stable fibrils of reduced cytotoxicity.
Topics: Amyloid beta-Peptides; Benzothiazoles; Calcium; Cell Line, Tumor; Cell Survival; Circular Dichroism; Cytosol; Humans; Microscopy, Atomic Force; Peptide Fragments; Peptides; Polysaccharides; Protein Binding; Protein Conformation; Protein Structure, Secondary; tau Proteins; Thiazoles | 2008 |
Acrolein, the toxic endogenous aldehyde, induces neurofilament-L aggregation.
Topics: Acrolein; Animals; Benzothiazoles; Fluorescent Dyes; Free Radical Scavengers; Humans; Mice; Neurodegenerative Diseases; Neurofilament Proteins; Protein Carbonylation; Thiazoles | 2008 |
Garlic extract exhibits antiamyloidogenic activity on amyloid-beta fibrillogenesis: relevance to Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Garlic; Humans; Microscopy, Electron, Transmission; Plant Extracts; Thiazoles | 2009 |
The binding of thioflavin T and its neutral analog BTA-1 to protofibrils of the Alzheimer's disease Abeta(16-22) peptide probed by molecular dynamics simulations.
Topics: Amyloid beta-Peptides; Benzothiazoles; Binding Sites; Computer Simulation; Humans; Ligands; Microscopy, Atomic Force; Models, Chemical; Molecular Conformation; Protein Binding; Protein Conformation; Protein Structure, Secondary; Structure-Activity Relationship; Thermodynamics; Thiazoles | 2008 |
Thioflavin T hydroxylation at basic pH and its effect on amyloid fibril detection.
Topics: Amyloid; Benzothiazoles; Hydrogen-Ion Concentration; Hydroxylation; Kinetics; Magnetic Resonance Spectroscopy; Spectrophotometry, Ultraviolet; Temperature; Thiazoles | 2008 |
Aggregates assembled from overexpression of wild-type alpha-synuclein are not toxic to human neuronal cells.
Topics: alpha-Synuclein; Analysis of Variance; Benzothiazoles; Cell Count; Cell Differentiation; Cell Fractionation; Cell Line, Tumor; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Microscopy, Electron, Transmission; Molecular Weight; Neuroblastoma; Neurofilament Proteins; Neurons; Tetracycline; Thiazoles; Time Factors; Transfection; Tretinoin | 2008 |
Analysis of the reaction of carbachol with acetylcholinesterase using thioflavin T as a coupled fluorescence reporter.
Topics: Acetylcholinesterase; Acetylthiocholine; Acylation; Benzothiazoles; Binding Sites; Carbachol; Catalysis; Fluorescent Dyes; Hydrolysis; Kinetics; Ligands; Spectrometry, Fluorescence; Substrate Specificity; Thermodynamics; Thiazoles | 2008 |
Real-time analysis of amyloid fibril formation of alpha-synuclein using a fibrillation-state-specific fluorescent probe of JC-1.
Topics: alpha-Synuclein; Amyloid; Benzimidazoles; Benzothiazoles; Carbocyanines; Computer Systems; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Humans; Models, Biological; Protein Binding; Protein Multimerization; Substrate Specificity; Thiazoles | 2009 |
Smoking and Parkinson's disease: does nicotine affect alpha-synuclein fibrillation?
Topics: alpha-Synuclein; Amino Acid Sequence; Anabasine; Benzothiazoles; Chromatography, Gel; Cotinine; Humans; Hydroquinones; Microscopy, Atomic Force; Molecular Sequence Data; Mutation; Nicotine; Parkinson Disease; Protein Binding; Protein Multimerization; Smoking; Thiazoles | 2009 |
Docosahexaenoic acid disrupts in vitro amyloid beta(1-40) fibrillation and concomitantly inhibits amyloid levels in cerebral cortex of Alzheimer's disease model rats.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antibodies; Benzothiazoles; Cerebral Cortex; Cholesterol; Disease Models, Animal; Docosahexaenoic Acids; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Hippocampus; Microscopy, Electron, Transmission; Neurofibrillary Tangles; Peptide Fragments; Rats; Rats, Wistar; Thiazoles | 2008 |
Cytoskeletal alterations differentiate presenilin-1 and sporadic Alzheimer's disease.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Autopsy; Benzothiazoles; Blotting, Western; Cohort Studies; Cytoskeleton; Humans; Immunohistochemistry; Middle Aged; Neurofibrillary Tangles; Phosphorylation; Plaque, Amyloid; Presenilin-1; Severity of Illness Index; tau Proteins; Thiazoles | 2009 |
Formation of highly toxic soluble amyloid beta oligomers by the molecular chaperone prefoldin.
Topics: Amyloid; Amyloid beta-Peptides; Animals; Antibodies; Apoptosis; Archaeal Proteins; Benzothiazoles; Caspase 3; Cell Survival; DNA Fragmentation; Electrophoresis, Polyacrylamide Gel; Humans; Immunoblotting; Microscopy, Electron, Transmission; Models, Biological; Molecular Chaperones; Particle Size; PC12 Cells; Peptide Fragments; Protein Binding; Protein Conformation; Pyrococcus; Rats; Recombinant Proteins; Solubility; Spectrometry, Fluorescence; Thiazoles | 2008 |
The polyphenol piceid destabilizes preformed amyloid fibrils and oligomers in vitro: hypothesis on possible molecular mechanisms.
Topics: Amyloid; Amyloid beta-Peptides; Benzothiazoles; Chromatography, Gel; Flavonoids; Fluorescent Dyes; Glucosides; Humans; Microscopy, Electron; Oligopeptides; Peptide Fragments; Phenols; Polyphenols; Protein Structure, Secondary; Spectrometry, Fluorescence; Stilbenes; Thiazoles | 2009 |
Molecular mechanism of thioflavin-T binding to the surface of beta-rich peptide self-assemblies.
Topics: Benzothiazoles; Binding Sites; Crystallography, X-Ray; Models, Biological; Models, Molecular; Peptides; Protein Structure, Secondary; Surface Properties; Thiazoles; Tyrosine | 2009 |
Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Antioxidants; Ascorbic Acid; Benzothiazoles; Blotting, Western; Brain; Cerebral Ventricles; Cysteine; Dietary Supplements; Female; Glutathione; Hippocampus; Humans; Immunohistochemistry; Male; Mice; Mice, Transgenic; Plaque, Amyloid; Resveratrol; Sirtuin 1; Sirtuins; Stilbenes; tau Proteins; Thiazoles; Transcription Factors; Tumor Suppressor Protein p53 | 2009 |
A new amyloid-like beta-aggregate with amyloid characteristics, except fibril morphology.
Topics: Amino Acid Substitution; Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Death; Cell Line, Tumor; Congo Red; Mice; Models, Biological; Mutant Proteins; Mutation; Peptides; Proline; Protein Structure, Quaternary; Protein Structure, Secondary; Thiazoles; Time Factors; Valine | 2009 |
Thioflavin T fluorescence assay for beta-lactoglobulin fibrils hindered by DAPH.
Topics: Amyloid; Benzothiazoles; Birefringence; Circular Dichroism; Fluorescent Dyes; Lactoglobulins; Microscopy, Electron, Transmission; Phthalimides; Rheology; Spectrometry, Fluorescence; Thiazoles; Viscosity | 2009 |
Ovine colostrum nanopeptide affects amyloid beta aggregation.
Topics: Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Line, Tumor; Cell Survival; Circular Dichroism; Fluorescent Dyes; Microscopy, Atomic Force; Nanostructures; Oligopeptides; Peptide Fragments; Protein Structure, Secondary; Rats; Sheep, Domestic; Thiazoles | 2009 |
Aggregate formation and toxicity by wild-type and R621C synphilin-1 in the nigrostriatal system of mice using adenoviral vectors.
Topics: Adenoviridae; Animals; Arginine; Benzothiazoles; Carrier Proteins; Corpus Striatum; Cysteine; Gene Expression; Genetic Vectors; Green Fluorescent Proteins; Intracellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Nerve Degeneration; Nerve Tissue Proteins; Substantia Nigra; Thiazoles; Tyrosine 3-Monooxygenase | 2009 |
Amyloid oligomers in diabetic and nondiabetic human pancreas.
Topics: Aged; Amyloid; Apoptosis; Benzothiazoles; Biomarkers; Blotting, Western; Caspase 3; Diabetes Mellitus, Type 2; Female; Fluorescent Antibody Technique, Indirect; Humans; Insulin; Islet Amyloid Polypeptide; Islets of Langerhans; Male; Protein Multimerization; Thiazoles | 2009 |
Synthesis and biological evaluation of radioiodinated 2NUBTA as a cerebral ischemia marker.
Topics: Animals; Benzothiazoles; Biomarkers; Blood-Brain Barrier; Brain Ischemia; Cell Line, Tumor; Humans; Hypoxia; Iodine Radioisotopes; Mice; Models, Chemical; Nitroimidazoles; Radionuclide Imaging; Temperature; Thiazoles | 2009 |
Design, selection, and characterization of thioflavin-based intercalation compounds with metal chelating properties for application in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Chelating Agents; Copper; Crystallography, X-Ray; Drug Design; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Concentration; Iodine; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Peptide Fragments; Thiazoles; Zinc | 2009 |
Tertiary butanol induced amyloidogenesis of hen egg white lysozyme (HEWL) is facilitated by aggregation-prone alkali-induced molten globule like conformational state.
Topics: Amyloid; Animals; Benzothiazoles; Chickens; Circular Dichroism; Female; Light; Muramidase; Protein Structure, Quaternary; Scattering, Radiation; Spectrometry, Fluorescence; tert-Butyl Alcohol; Thiazoles | 2009 |
Dissecting the mechanisms of tissue transglutaminase-induced cross-linking of alpha-synuclein: implications for the pathogenesis of Parkinson disease.
Topics: alpha-Synuclein; Benzothiazoles; Circular Dichroism; Cross-Linking Reagents; Dimerization; Glutamine; Humans; Immunoblotting; Mutagenesis, Site-Directed; Mutation; Parkinson Disease; Protein Conformation; Spectrometry, Mass, Electrospray Ionization; Thiazoles; Transglutaminases | 2009 |
Photophysical studies on the noncovalent interaction of thioflavin T with cucurbit[n]uril macrocycles.
Topics: Benzothiazoles; Bridged-Ring Compounds; Computer Simulation; Imidazoles; Magnetic Resonance Spectroscopy; Models, Chemical; Molecular Structure; Photochemistry; Solutions; Spectrometry, Fluorescence; Thiazoles; Time Factors; Water | 2009 |
Nano-scale imaging and dynamics of amylin-membrane interactions and its implication in type II diabetes mellitus.
Topics: Aluminum Silicates; Amyloid; Animals; Benzothiazoles; Biological Assay; Cell Membrane; Cholesterol; Circular Dichroism; Diabetes Mellitus, Type 2; Fluorescence; Humans; Imaging, Three-Dimensional; Islet Amyloid Polypeptide; Liposomes; Microscopy, Atomic Force; Models, Biological; Nanotechnology; Phase Transition; Phospholipids; Protein Structure, Quaternary; Protein Structure, Secondary; Rats; Solutions; Surface Properties; Thiazoles | 2008 |
Characterization of type I collagen fibril formation using thioflavin T fluorescent dye.
Topics: Animals; Benzothiazoles; Centrifugation; Circular Dichroism; Collagen; Electrophoresis, Polyacrylamide Gel; Fibrillar Collagens; Fluorescent Dyes; Hydrogen-Ion Concentration; Protein Stability; Spectrometry, Fluorescence; Temperature; Thiazoles; Tuna | 2009 |
Modulation of aggregate size- and shape-distributions of the amyloid-beta peptide by a designed beta-sheet breaker.
Topics: Amyloid beta-Peptides; Benzothiazoles; Calcium Carbonate; Centrifugation, Density Gradient; Citrates; Dimethyl Sulfoxide; Drug Combinations; Fluorescence; Magnesium Oxide; Microscopy, Electron, Transmission; Molecular Weight; Peptide Fragments; Protein Multimerization; Protein Structure, Quaternary; Protein Structure, Secondary; Signal Processing, Computer-Assisted; Software; Thiazoles; Time Factors | 2010 |
Agitation and high ionic strength induce amyloidogenesis of a folded PDZ domain in native conditions.
Topics: Amyloid; Anilino Naphthalenesulfonates; Animals; Benzothiazoles; Circular Dichroism; Fluorescence; Kinetics; Mice; Microscopy, Atomic Force; Models, Molecular; Motion; Osmolar Concentration; PDZ Domains; Protein Folding; Protein Structure, Secondary; Protein Tyrosine Phosphatase, Non-Receptor Type 13; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2009 |
Existence of different structural intermediates on the fibrillation pathway of human serum albumin.
Topics: Amyloid; Benzothiazoles; Circular Dichroism; Congo Red; Fluorescence; Humans; Hydrogen-Ion Concentration; Kinetics; Microscopy, Atomic Force; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Protein Conformation; Protein Folding; Serum Albumin; Spectroscopy, Fourier Transform Infrared; Temperature; Thiazoles; Time Factors; Tryptophan; X-Ray Diffraction | 2009 |
Anti-aggregation and fibril-destabilizing effects of sex hormones on alpha-synuclein fibrils in vitro.
Topics: alpha-Synuclein; Benzothiazoles; Estradiol; Estriol; Gonadal Steroid Hormones; Humans; In Vitro Techniques; Lewy Bodies; Lewy Body Disease; Microscopy, Electron; Molecular Structure; Neurofibrils; Neuroprotective Agents; Parkinson Disease; Spectrometry, Fluorescence; Testosterone; Thiazoles | 2009 |
CE can identify small molecules that selectively target soluble oligomers of amyloid beta protein and display antifibrillogenic activity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Cell Line, Tumor; Cell Survival; Electrophoresis, Capillary; Humans; Isoquinolines; Microscopy, Electron, Transmission; Mitoxantrone; Neuroprotective Agents; Particle Size; Peptide Fragments; Plaque, Amyloid; Protein Multimerization; Spectrometry, Fluorescence; Suramin; Thiazoles | 2009 |
Stereospecific interactions are necessary for Alzheimer disease amyloid-β toxicity.
Topics: Amyloid beta-Peptides; Animals; Annexin A5; Benzothiazoles; Biophysics; Cell Death; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Electric Stimulation; Electron Spin Resonance Spectroscopy; Embryo, Mammalian; Hydrogen Peroxide; Long-Term Potentiation; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Neurons; Patch-Clamp Techniques; Protein Binding; Protein Conformation; Protein Structure, Secondary; Thiazoles; Time Factors; Tyrosine | 2011 |
Amyloid beta (1-42) folding multiplicity and single-molecule binding behavior studied with STM.
Topics: Amyloid beta-Peptides; Benzothiazoles; Coloring Agents; Congo Red; Fluorescent Dyes; Microscopy, Scanning Tunneling; Molecular Structure; Peptide Fragments; Protein Binding; Protein Conformation; Protein Folding; Thiazoles | 2009 |
Evidence for novel beta-sheet structures in Iowa mutant beta-amyloid fibrils.
Topics: Amyloid; Amyloid beta-Peptides; Amyloid Neuropathies, Familial; Aspartic Acid; Benzothiazoles; Glutamic Acid; Humans; Kinetics; Leucine; Lysine; Microscopy, Electron, Transmission; Models, Molecular; Mutation, Missense; Nuclear Magnetic Resonance, Biomolecular; Peptide Fragments; Phenylalanine; Protein Structure, Secondary; Spectrometry, Fluorescence; Thiazoles; X-Ray Diffraction | 2009 |
Parcellation of human temporal polar cortex: a combined analysis of multiple cytoarchitectonic, chemoarchitectonic, and pathological markers.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Antigens, Nuclear; Benzothiazoles; Female; Histocytochemistry; Humans; Immunohistochemistry; Male; Nerve Tissue Proteins; Plant Lectins; Pyramidal Cells; Receptors, N-Acetylglucosamine; Tauopathies; Temporal Lobe; Thiazoles | 2009 |
Thioflavin T as a molecular rotor: fluorescent properties of thioflavin T in solvents with different viscosity.
Topics: Benzothiazoles; Fluorescent Dyes; Glycerol; Molecular Structure; Solvents; Temperature; Thiazoles; Time Factors; Viscosity | 2008 |
Synthetic lipid vesicles recruit native-like aggregates and affect the aggregation process of the prion Ure2p: insights on vesicle permeabilization and charge selectivity.
Topics: Animals; Benzothiazoles; Calcium; Cell Line, Tumor; Cell Membrane Permeability; Cell Survival; Chlorides; Cholesterol; Circular Dichroism; Fluoresceins; Fluorescence; Glutathione Peroxidase; Membrane Potentials; Mice; Microscopy, Electron, Transmission; Phosphatidylcholines; Phosphatidylserines; Photomicrography; Prions; Saccharomyces cerevisiae Proteins; Thiazoles; Unilamellar Liposomes | 2009 |
Bovine insulin filaments induced by reducing disulfide bonds show a different morphology, secondary structure, and cell toxicity from intact insulin amyloid fibrils.
Topics: Amyloid; Animals; Benzothiazoles; Cattle; Cell Death; Circular Dichroism; Congo Red; Insulin; Microscopy, Electron, Transmission; Phosphines; Protein Structure, Secondary; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Thiazoles; Ultraviolet Rays | 2009 |
Detection of interactions of the beta-amyloid peptide with small molecules employing transferred NOEs.
Topics: Amyloid beta-Peptides; Benzothiazoles; Iridoid Glucosides; Iridoids; Magnetic Resonance Spectroscopy; Melatonin; Molecular Structure; Pyrans; Thiazoles | 2009 |
Effects of docosahexaenoic acid on in vitro amyloid beta peptide 25-35 fibrillation.
Topics: Amyloid; Amyloid beta-Peptides; Benzothiazoles; Docosahexaenoic Acids; Dose-Response Relationship, Drug; Fluorescent Dyes; Humans; In Vitro Techniques; Microscopy, Confocal; Neurofibrillary Tangles; Peptide Fragments; Thiazoles | 2009 |
Comparative study of inhibition at multiple stages of amyloid-beta self-assembly provides mechanistic insight.
Topics: Aldehydes; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Inhibitory Concentration 50; Light; Molecular Structure; Peptide Fragments; Protein Binding; Protein Conformation; Quinolizines; Scattering, Radiation; Solubility; Spectrometry, Fluorescence; Structure-Activity Relationship; Thiazoles | 2009 |
Ultrafast torsional dynamics of protein binding dye thioflavin-T in nanoconfined water pool.
Topics: Absorption; Benzothiazoles; Fluorescence Polarization; Fluorescent Dyes; Kinetics; Micelles; Nanotechnology; Proteins; Spectrometry, Fluorescence; Thiazoles; Time Factors; Water | 2009 |
Interactions of thioflavin T with serum albumins: spectroscopic analyses.
Topics: Animals; Benzothiazoles; Binding Sites; Cattle; Humans; Models, Biological; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Rabbits; Serum Albumin; Spectrum Analysis; Swine; Thiazoles | 2009 |
D-Ribosylated Tau forms globular aggregates with high cytotoxicity.
Topics: Alzheimer Disease; Animals; Benzothiazoles; Cell Line; Fluorescent Dyes; Glycosylation; Humans; Microscopy, Atomic Force; Molecular Sequence Data; Neurofibrillary Tangles; Protein Conformation; Ribose; tau Proteins; Thiazoles | 2009 |
Neuronal response of peroxisomal and peroxisome-related proteins to chronic and acute Abeta injury.
Topics: Amyloid beta-Peptides; Animals; Apoptosis; Benzothiazoles; Cell Survival; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; Gene Expression Regulation, Enzymologic; Glutathione S-Transferase pi; Indoles; Insulysin; Nerve Tissue Proteins; Neurons; Peptide Fragments; Peroxidases; PPAR alpha; Rats; Reactive Oxygen Species; Superoxide Dismutase; Tetrazolium Salts; Thiazoles; Time Factors | 2009 |
Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Cerebral Cortex; Disease Models, Animal; Hippocampus; Humans; Memory; Memory Disorders; Mice; Mice, Transgenic; Organ Size; Peptide Fragments; Physical Conditioning, Animal; Protease Nexins; Random Allocation; Receptors, Cell Surface; Recognition, Psychology; Thiazoles; Time Factors | 2009 |
Rapid method for measurement of acetylcholinesterase activity.
Topics: Acetylcholinesterase; Benzothiazoles; Cholinesterase Inhibitors; Erythrocytes; Fluorescent Dyes; Humans; Spectrometry, Fluorescence; Thiazoles | 2009 |
Amyloid fibril-like structure underlies the aggregate structure across the pH range for beta-lactoglobulin.
Topics: Amyloid; Animals; Benzothiazoles; Humans; Hydrogen-Ion Concentration; Lactoglobulins; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Models, Molecular; Spectroscopy, Fourier Transform Infrared; Thiazoles; X-Ray Diffraction | 2009 |
Structural characterization of clusterin-chaperone client protein complexes.
Topics: Benzothiazoles; Circular Dichroism; Clusterin; Densitometry; Enzyme-Linked Immunosorbent Assay; Fibrinogen; Glutathione Transferase; Humans; Light; Molecular Chaperones; Protein Conformation; Protein Structure, Secondary; Proteins; Scattering, Radiation; Thiazoles; Time Factors | 2009 |
Rapid aggregation and assembly in aqueous solution of A beta (25-35) peptide.
Topics: Amyloid beta-Peptides; Benzothiazoles; Congo Red; Humans; Hydrogen-Ion Concentration; Kinetics; Models, Statistical; Nephelometry and Turbidimetry; Neurotoxins; Peptide Fragments; Peptides; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Thiazoles; Time Factors; Water | 2009 |
Effect of curcumin on amyloidogenic property of molten globule-like intermediate state of 2,5-diketo-D-gluconate reductase A.
Topics: Amyloid; Amyloidosis; Benzothiazoles; Biological Assay; Circular Dichroism; Curcumin; Hydrogen-Ion Concentration; Microscopy, Atomic Force; Protein Folding; Protein Structure, Secondary; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Sugar Alcohol Dehydrogenases; Thiazoles; Time Factors | 2009 |
Inhibition of Abeta42 aggregation using peptides selected from combinatorial libraries.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Benzothiazoles; Drug Evaluation, Preclinical; Molecular Sequence Data; Peptide Library; Peptides; Thiazoles | 2009 |
The functional curli amyloid is not based on in-register parallel beta-sheet structure.
Topics: Amino Acid Sequence; Amyloid; Benzothiazoles; Biofilms; Circular Dichroism; Endopeptidase K; Escherichia coli; Escherichia coli Proteins; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Prions; Protein Structure, Secondary; Recombinant Proteins; Sequence Homology, Amino Acid; Spectrometry, Fluorescence; Thiazoles | 2009 |
Fibrils from designed non-amyloid-related synthetic peptides induce AA-amyloidosis during inflammation in an animal model.
Topics: Amyloid; Amyloidosis; Animals; Benzothiazoles; Coloring Agents; Congo Red; Disease Models, Animal; Female; Humans; Inflammation; Mice; Peptides; Spleen; Thiazoles; Time Factors | 2009 |
Self-organization pathways and spatial heterogeneity in insulin amyloid fibril formation.
Topics: Amyloid; Animals; Benzothiazoles; Cattle; Hot Temperature; Hydrochloric Acid; Insulin; Microscopy, Atomic Force; Thiazoles | 2009 |
Self-assembled hydrogels from poly[N-(2-hydroxypropyl)methacrylamide] grafted with beta-sheet peptides.
Topics: Acrylamides; Benzothiazoles; Circular Dichroism; Hydrogels; Microscopy, Electron, Transmission; Peptide Fragments; Protein Conformation; Protein Folding; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2009 |
Zn(II)- and Cu(II)-induced non-fibrillar aggregates of amyloid-beta (1-42) peptide are transformed to amyloid fibrils, both spontaneously and under the influence of metal chelators.
Topics: Alanine; Amyloid; Amyloid beta-Peptides; Animals; Benzothiazoles; Cells, Cultured; Cerebral Cortex; Chelating Agents; Copper; Dose-Response Relationship, Drug; Histidine; Metallothionein 3; Microscopy, Electron, Transmission; Mutation; Nerve Tissue Proteins; Neurons; Peptide Fragments; Rats; Thiazoles; Time Factors; Zinc | 2009 |
A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta.
Topics: Amyloid beta-Peptides; Benzothiazoles; Coloring Agents; Congo Red; Fluorescent Dyes; Indoles; Spectrometry, Fluorescence; Thiazoles | 2009 |
Near-field scanning optical microscopy measurements of fluorescent molecular probes binding to insulin amyloid fibrils.
Topics: Amyloid; Aniline Compounds; Animals; Benzothiazoles; Biophysics; Cattle; Fluorescent Dyes; Hydrogen-Ion Concentration; Insulin; Magnetic Resonance Spectroscopy; Micelles; Microscopy, Atomic Force; Microscopy, Fluorescence; Protein Binding; Thiazoles | 2009 |
Effects of non-steroidal anti-inflammatory drugs on Abeta deposition in Abeta(1-42) transgenic C. elegans.
Topics: Amyloid beta-Peptides; Analysis of Variance; Animals; Animals, Genetically Modified; Anti-Inflammatory Agents, Non-Steroidal; Benzothiazoles; Caenorhabditis elegans; Diclofenac; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Ibuprofen; Indomethacin; Microscopy, Confocal; Thiazoles | 2009 |
A New Transgenic Mouse Model of Gerstmann-Straussler-Scheinker Syndrome Caused by the A117V Mutation of PRNP.
Topics: Animals; Ataxia; Benzothiazoles; Blotting, Western; Brain; Creutzfeldt-Jakob Syndrome; Disease Models, Animal; Gerstmann-Straussler-Scheinker Disease; Humans; Kaplan-Meier Estimate; Mice; Mice, Transgenic; Mutation, Missense; Phenotype; Prion Proteins; Prions; PrPC Proteins; PrPSc Proteins; Thiazoles; Time Factors | 2009 |
Mechanism of docosahexaenoic acid-induced inhibition of in vitro Abeta1-42 fibrillation and Abeta1-42-induced toxicity in SH-S5Y5 cells.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Cell Line; Docosahexaenoic Acids; Dose-Response Relationship, Drug; Fluorescent Dyes; Humans; In Vitro Techniques; Microscopy, Confocal; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Neurofibrillary Tangles; Peptide Fragments; Spectrum Analysis; Thiazoles | 2009 |
Thioflavin S (NSC71948) interferes with Bcl-2-associated athanogene (BAG-1)-mediated protein-protein interactions.
Topics: Animals; Benzothiazoles; Cell Line; Cell Proliferation; DNA-Binding Proteins; Extracellular Signal-Regulated MAP Kinases; Fluorescent Dyes; HSC70 Heat-Shock Proteins; Humans; Luciferases; Mice; Phosphorylation; Plasmids; Receptors, Calcitriol; Serum Albumin, Bovine; Small Molecule Libraries; Thiazoles; Transcription Factors | 2009 |
Kinetic analysis of amyloid formation in the presence of heparan sulfate: faster unfolding and change of pathway.
Topics: Acid Anhydride Hydrolases; Acylphosphatase; Amyloid; Benzothiazoles; Circular Dichroism; Extracellular Matrix; Heparitin Sulfate; Humans; Kinetics; Muscle Proteins; Protein Structure, Quaternary; Protein Structure, Secondary; Thiazoles | 2009 |
Morphology of self-assembled structures formed by short peptides from the amyloidogenic protein tau depends on the solvent in which the peptides are dissolved.
Topics: Benzothiazoles; Circular Dichroism; Microscopy, Atomic Force; Microscopy, Fluorescence; Peptide Fragments; Propanols; Protein Conformation; Protein Structure, Secondary; Solvents; Spectroscopy, Fourier Transform Infrared; tau Proteins; Thiazoles; Trifluoroethanol | 2009 |
On the stability of the soluble amyloid aggregates.
Topics: Amyloid beta-Peptides; Bacillus; Bacterial Proteins; Benzothiazoles; Humans; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Linear Models; Models, Biological; Nanoparticles; Nonlinear Dynamics; Osmolar Concentration; Peptide Fragments; Protein Multimerization; Protein Stability; Spectrometry, Fluorescence; Static Electricity; Thiazoles | 2009 |
Oligomers of beta-amyloid are sequestered into and seed new plaques in the brains of an AD mouse model.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Benzothiazoles; Biotin; Disease Models, Animal; Humans; Immunohistochemistry; Islet Amyloid Polypeptide; Ligands; Male; Mice; Mice, Transgenic; Microscopy, Atomic Force; Molecular Weight; Peptide Fragments; Plaque, Amyloid; Thiazoles | 2010 |
Resveratrol inhibits beta-amyloid oligomeric cytotoxicity but does not prevent oligomer formation.
Topics: Amyloid; Amyloid beta-Peptides; Animals; Antioxidants; Benzothiazoles; Cell Proliferation; Circular Dichroism; Dose-Response Relationship, Drug; Humans; Mice; Microscopy, Electron, Transmission; Molecular Conformation; Molecular Structure; Neuroblastoma; Peptide Fragments; Protein Structure, Quaternary; Resveratrol; Spectrometry, Fluorescence; Stilbenes; Tetrazolium Salts; Thiazoles | 2009 |
Copper abolishes the beta-sheet secondary structure of preformed amyloid fibrils of amyloid-beta(42).
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Birefringence; Congo Red; Copper; Fluorescent Dyes; Humans; Microscopy, Electron, Transmission; Peptide Fragments; Peptides; Protein Structure, Secondary; Thiazoles | 2009 |
The thioflavin T fluorescence assay for amyloid fibril detection can be biased by the presence of exogenous compounds.
Topics: Amyloid; Benzothiazoles; Biological Assay; Curcumin; Fluorescent Dyes; Quercetin; Reproducibility of Results; Resveratrol; Spectrometry, Fluorescence; Stilbenes; Thiazoles | 2009 |
Immunohistochemical analysis of human brain suggests pathological synergism of Alzheimer's disease and diabetes mellitus.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Brain; Cell Count; Diabetes Mellitus; Female; Fluorescent Antibody Technique; Glycation End Products, Advanced; Humans; Immunohistochemistry; Male; Microglia; Middle Aged; Peptide Fragments; Plant Lectins; Plaque, Amyloid; Receptor for Advanced Glycation End Products; Receptors, Immunologic; tau Proteins; Thiazoles | 2010 |
Inhibition of beta 1-40 amyloid fibrillation with N-acetyl-L-cysteine capped quantum dots.
Topics: Acetylcysteine; Amyloid beta-Peptides; Benzothiazoles; Fluorescent Dyes; Kinetics; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Peptide Fragments; Quantum Dots; Thiazoles | 2010 |
Binding modes of thioflavin-T to the single-layer beta-sheet of the peptide self-assembly mimics.
Topics: Amyloid beta-Peptides; Benzothiazoles; Binding Sites; Kinetics; Models, Molecular; Protein Binding; Protein Structure, Secondary; Thiazoles | 2009 |
Fibril fragmentation enhances amyloid cytotoxicity.
Topics: Amyloid; Amyloidosis; Animals; Benzothiazoles; Cell Survival; Chickens; HeLa Cells; Humans; Kinetics; Liposomes; Mice; Microscopy, Atomic Force; Models, Biological; Spectroscopy, Fourier Transform Infrared; Tetrazolium Salts; Thiazoles | 2009 |
Impaired processing of human pro-islet amyloid polypeptide is not a causative factor for fibril formation or membrane damage in vitro.
Topics: Amyloid; Benzothiazoles; Circular Dichroism; Fluoresceins; Humans; Islet Amyloid Polypeptide; Kinetics; Membranes, Artificial; Models, Molecular; Permeability; Protein Multimerization; Protein Processing, Post-Translational; Protein Structure, Secondary; Spectrometry, Fluorescence; Surface Tension; Thiazoles; Unilamellar Liposomes | 2009 |
Searching for conditions to form stable protein oligomers with amyloid-like characteristics: The unexplored basic pH.
Topics: Amyloid; Benzothiazoles; Carboxyl and Carbamoyl Transferases; Circular Dichroism; Congo Red; Escherichia coli Proteins; Hydrogen-Ion Concentration; Microscopy, Atomic Force; Models, Molecular; Protein Conformation; Protein Denaturation; Protein Folding; Protein Multimerization; Protein Structure, Quaternary; Spectrometry, Fluorescence; Thiazoles; Trifluoroethanol; Tryptophan | 2010 |
Site-specific modification of Alzheimer's peptides by cholesterol oxidation products enhances aggregation energetics and neurotoxicity.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Benzothiazoles; Cells, Cultured; Cholesterol; Fluorescence; Kinetics; Light; Microscopy, Immunoelectron; Molecular Sequence Data; Mutagenesis, Site-Directed; Neurons; Oxidation-Reduction; Peptides; Protein Structure, Quaternary; Rats; Scattering, Radiation; Thiazoles | 2009 |
Role of zinc along with ascorbic acid and folic acid during long-term in vitro albumin glycation.
Topics: Ascorbic Acid; Benzothiazoles; Cell Survival; Congo Red; Folic Acid; Glycation End Products, Advanced; Glycosylation; Hep G2 Cells; Humans; Kinetics; Protein Binding; Serum Albumin, Bovine; Sulfhydryl Compounds; Thiazoles; Zinc | 2010 |
Thioflavin T fluorescence in human serum: correlations with vascular health and cardiovascular risk factors.
Topics: Adult; Amyloid beta-Peptides; Animals; Benzothiazoles; Biomarkers; Cardiovascular Diseases; Cattle; Fluorescence; Humans; Male; Middle Aged; Pyruvaldehyde; Risk Factors; Serum Albumin; Thiazoles | 2010 |
Tyrosine autofluorescence as a measure of bovine insulin fibrillation.
Topics: Anilino Naphthalenesulfonates; Animals; Benzothiazoles; Biophysics; Cattle; Insulin; Kinetics; Light; Protein Conformation; Protein Structure, Secondary; Scattering, Radiation; Spectrometry, Fluorescence; Temperature; Thiazoles; Tyrosine | 2009 |
RNA aptamers generated against oligomeric Abeta40 recognize common amyloid aptatopes with low specificity but high sensitivity.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Aptamers, Nucleotide; Benzothiazoles; Densitometry; Dimerization; DNA, Single-Stranded; Humans; Ligands; Peptide Fragments; Protein Binding; Protein Folding; Protein Structure, Secondary; Thiazoles | 2009 |
Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Line, Tumor; Cytoplasmic Vesicles; Fluorescence; Humans; Immunoblotting; Mice; Microscopy, Confocal; Neurons; Plaque, Amyloid; Thiazoles | 2009 |
Lability landscape and protease resistance of human insulin amyloid: a new insight into its molecular properties.
Topics: Amyloid; Benzothiazoles; Circular Dichroism; Electrophoresis; Endopeptidase K; Enzyme Stability; Humans; Hydrogen-Ion Concentration; Insulin; Kinetics; Microscopy, Atomic Force; Models, Molecular; Protein Binding; Protein Structure, Quaternary; Solutions; Spectrum Analysis; Thiazoles; Time Factors | 2010 |
Revealing of Saccharomyces cerevisiae yeast cell wall proteins capable of binding thioflavin T, a fluorescent dye specifically interacting with amyloid fibrils.
Topics: Amyloid; Benzothiazoles; Cell Wall; Fluorescent Dyes; Protein Binding; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Thiazoles | 2009 |
Interaction between oligomers of stefin B and amyloid-beta in vitro and in cells.
Topics: Amyloid beta-Peptides; Animals; Benzothiazoles; CHO Cells; Cricetinae; Cricetulus; Cystatin B; Dimerization; Enzyme-Linked Immunosorbent Assay; Epitopes; Humans; In Vitro Techniques; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Protein Binding; Spectrometry, Mass, Electrospray Ionization; Surface Plasmon Resonance; Thiazoles | 2010 |
Domain a' of protein disulfide isomerase plays key role in inhibiting alpha-synuclein fibril formation.
Topics: alpha-Synuclein; Benzothiazoles; Calorimetry; Humans; Protein Disulfide-Isomerases; Protein Structure, Tertiary; Recombinant Proteins; Thiazoles | 2010 |
Probing the amyloid-beta(1-40) fibril environment with substituted tryptophan residues.
Topics: Amino Acid Sequence; Amino Acid Substitution; Amyloid beta-Peptides; Benzothiazoles; Hydrophobic and Hydrophilic Interactions; Molecular Sequence Data; Peptide Fragments; Protein Structure, Secondary; Spectrometry, Fluorescence; Thiazoles; Tryptophan | 2010 |
Oligomerization and insulin interactions of proinsulin C-peptide: Threefold relationships to properties of insulin.
Topics: Benzothiazoles; C-Peptide; Fluorescent Dyes; Humans; Insulin; Protein Stability; Spectrometry, Mass, Electrospray Ionization; Thiazoles | 2010 |
Yeast cell adhesion molecules have functional amyloid-forming sequences.
Topics: Amino Acid Sequence; Amyloid; Benzothiazoles; Birefringence; Calcium; Candida albicans; Cell Adhesion Molecules; Cell Aggregation; Cell Proliferation; Circular Dichroism; Congo Red; Fungal Proteins; Mannose-Binding Lectins; Membrane Glycoproteins; Microscopy, Fluorescence; Microscopy, Polarization; Models, Molecular; Peptide Fragments; Peptide Initiation Factors; Protein Structure, Secondary; Recombinant Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Spectrometry, Fluorescence; Thiazoles; Transfection; Yeasts | 2010 |
Cooperative metal ion binding to a cucurbit[7]uril-thioflavin T complex: demonstration of a stimulus-responsive fluorescent supramolecular capsule.
Topics: Benzothiazoles; Binding Sites; Bridged-Ring Compounds; Imidazoles; Ions; Magnetic Resonance Spectroscopy; Metals; Models, Molecular; Molecular Structure; Spectrometry, Fluorescence; Thiazoles | 2010 |
DnaK/DnaJ/GrpE of Hsp70 system have differing effects on alpha-synuclein fibrillation involved in Parkinson's disease.
Topics: alpha-Synuclein; Amino Acid Sequence; Benzothiazoles; Chromatography, Gel; HSP40 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Molecular Sequence Data; Parkinson Disease; Protein Structure, Quaternary; Thiazoles; Time Factors | 2010 |
Ultrafast bond twisting dynamics in amyloid fibril sensor.
Topics: Amyloid; Benzothiazoles; Fluorescent Dyes; Kinetics; Molecular Dynamics Simulation; Quantum Theory; Spectrometry, Fluorescence; Thiazoles | 2010 |
Critical role of interfaces and agitation on the nucleation of Abeta amyloid fibrils at low concentrations of Abeta monomers.
Topics: Air; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Brain Chemistry; Fluorescent Dyes; Humans; In Vitro Techniques; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Neurodegenerative Diseases; Peptide Fragments; Protein Binding; Protein Conformation; Protein Multimerization; Solutions; Spectrometry, Fluorescence; Thiazoles; Water | 2010 |
Crystal structure of thioflavin-T and its binding to amyloid fibrils: insights at the molecular level.
Topics: Amyloid beta-Peptides; Benzothiazoles; Binding Sites; Crystallography, X-Ray; Fluorescent Dyes; Molecular Conformation; Peptide Fragments; Protein Binding; Protein Structure, Secondary; Thiazoles | 2010 |
A novel, high-efficiency cellular model of fibrillar alpha-synuclein inclusions and the examination of mutations that inhibit amyloid formation.
Topics: alpha-Synuclein; Amyloid; Benzothiazoles; Calcium Phosphates; Cell Line, Transformed; Humans; Hydrophobic and Hydrophilic Interactions; Inclusion Bodies; Point Mutation; Thiazoles; Transfection | 2010 |
Methionine oxidation induces amyloid fibril formation by full-length apolipoprotein A-I.
Topics: Amyloid; Apolipoprotein A-I; Benzothiazoles; Crystallography, X-Ray; Humans; In Vitro Techniques; Methionine; Microscopy, Electron, Transmission; Models, Molecular; Oxidation-Reduction; Protein Folding; Protein Multimerization; Protein Stability; Thermodynamics; Thiazoles | 2010 |
Design, synthesis and biological evaluation of indane-2-arylhydrazinylmethylene-1,3-diones and indol-2-aryldiazenylmethylene-3-ones as beta-amyloid aggregation inhibitors.
Topics: Amyloid beta-Peptides; Benzothiazoles; Hydrogen Bonding; Indoles; Magnetic Resonance Spectroscopy; Microscopy, Electron, Transmission; Peptide Fragments; Spectrometry, Fluorescence; Thiazoles | 2010 |
Strategies to increase the reproducibility of protein fibrillization in plate reader assays.
Topics: alpha-Synuclein; Benzothiazoles; Fluorescent Dyes; Humans; Kinetics; Parkinson Disease; Recombinant Proteins; Reproducibility of Results; Sodium Dodecyl Sulfate; Thiazoles | 2010 |
The therapeutic effects of the herbal medicine, Juzen-taiho-to, on amyloid-beta burden in a mouse model of Alzheimer's disease.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antigens, CD; Antipsychotic Agents; Benzothiazoles; Bone Marrow Cells; Calcium-Binding Proteins; Cell Culture Techniques; Cytokines; Disease Models, Animal; DNA-Binding Proteins; Drugs, Chinese Herbal; Flow Cytometry; Gene Expression Regulation; Humans; Ki-67 Antigen; Macrophages; Mice; Mice, Transgenic; Microfilament Proteins; Mutation; Thiazoles | 2010 |
PB1-F2 influenza A virus protein adopts a beta-sheet conformation and forms amyloid fibers in membrane environments.
Topics: Acetonitriles; Amyloid; Animals; Benzothiazoles; Cell Line; Cell Membrane; Dogs; Humans; Influenza A virus; Mutation; Protein Structure, Secondary; Recombinant Proteins; Thiazoles; Trifluoroethanol; Viral Proteins | 2010 |
Density functional theory analysis and spectral studies on amyloid peptide Abeta(28-35) and its mutants A30G and A30I.
Topics: Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Peptides; Benzothiazoles; Circular Dichroism; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; In Vitro Techniques; Models, Molecular; Mutagenesis, Site-Directed; Mutant Proteins; Peptide Fragments; Protein Conformation; Protein Stability; Protein Structure, Secondary; Spectrometry, Fluorescence; Static Electricity; Thermodynamics; Thiazoles | 2010 |
The interaction of alphaB-crystallin with mature alpha-synuclein amyloid fibrils inhibits their elongation.
Topics: alpha-Crystallin B Chain; alpha-Synuclein; Amyloid; Benzothiazoles; Fluorescence; Kinetics; Magnetic Resonance Spectroscopy; Molecular Chaperones; Protein Binding; Protein Structure, Quaternary; Quartz; Thiazoles | 2010 |
Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease.
Topics: alpha-Synuclein; Benzothiazoles; Fetal Tissue Transplantation; Humans; Lewy Bodies; Longitudinal Studies; Male; Mesencephalon; Microscopy, Electron, Transmission; Middle Aged; Neurons; Parkinson Disease; Postmortem Changes; Thiazoles; Time Factors | 2010 |
L-Arginine reduces thioflavin T fluorescence but not fibrillation of bovine serum albumin.
Topics: Animals; Arginine; Benzothiazoles; Binding Sites; Cattle; Fluorescence; Microscopy, Electron, Transmission; Protein Binding; Protein Conformation; Serum Albumin, Bovine; Thiazoles | 2010 |
Novel fluorescent trimethine cyanine dye 7519 for amyloid fibril inhibition assay.
Topics: Amyloid; Benzothiazoles; Biological Assay; Carbocyanines; Flavonoids; Fluorescent Dyes; Insulin; Quantitative Structure-Activity Relationship; Reference Standards; Spectrometry, Fluorescence; Thiazoles | 2011 |
Development of a proteolytically stable retro-inverso peptide inhibitor of beta-amyloid oligomerization as a potential novel treatment for Alzheimer's disease.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Aggregation; Cell Line; Cell Survival; Humans; Immunoassay; Molecular Sequence Data; Peptide Fragments; Peptides; Surface Plasmon Resonance; Thiazoles | 2010 |
beta-Sheet aggregation of kisspeptin-10 is stimulated by heparin but inhibited by amphiphiles.
Topics: Amino Acid Sequence; Animals; Benzothiazoles; Circular Dichroism; Fluorescent Dyes; Heparin; Hydrogen-Ion Concentration; In Vitro Techniques; Kisspeptins; Mice; Micelles; Microscopy, Atomic Force; Oligopeptides; Protein Multimerization; Protein Structure, Secondary; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Surface-Active Agents; Thiazoles | 2010 |
Burden of neurodegenerative diseases in a cohort of medical examiner subjects.
Topics: Adult; Aged; Aged, 80 and over; alpha-Synuclein; Alzheimer Disease; Atrophy; Benzothiazoles; Brain; Brain Edema; Cohort Studies; Coroners and Medical Examiners; Female; Forensic Pathology; Frontotemporal Lobar Degeneration; Humans; Hygiene; Ill-Housed Persons; Immunohistochemistry; Male; Malnutrition; Middle Aged; Neurofibrillary Tangles; Neuropil Threads; Plaque, Amyloid; Staining and Labeling; Tauopathies; Thiazoles; Young Adult | 2010 |
Abeta20-29 peptide blocking apoE/Abeta interaction reduces full-length Abeta42/40 fibril formation and cytotoxicity in vitro.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Apolipoproteins E; Benzothiazoles; Cell Survival; Cells, Cultured; Fluorescent Dyes; Humans; Microscopy, Electron; Neurofibrils; Peptide Fragments; Spectrometry, Fluorescence; Tetrazolium Salts; Thiazoles | 2010 |
Multidimensional structure-activity relationship of a protein in its aggregated states.
Topics: Adenosine Triphosphate; Benzothiazoles; Cell Survival; DNA; Protein Structure, Secondary; Proteins; Structure-Activity Relationship; Thiazoles | 2010 |
Laser-induced propagation and destruction of amyloid beta fibrils.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; beta 2-Microglobulin; Humans; Kinetics; Lasers; Models, Biological; Peptide Fragments; Peptides; Photochemotherapy; Protein Folding; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiazoles; Ultracentrifugation | 2010 |
Intrinsic determinants of neurotoxic aggregate formation by the amyloid beta peptide.
Topics: Amyloid beta-Peptides; Animals; Benzothiazoles; Drosophila melanogaster; Kinetics; Longevity; Mutant Proteins; Mutation; Neurotoxins; Protein Structure, Quaternary; Thiazoles; Time Factors | 2010 |
Complement protein C1q forms a complex with cytotoxic prion protein oligomers.
Topics: Amyloid; Animals; Benzothiazoles; Chromatography; Complement C1q; Complement C4; Complement System Proteins; Humans; Immunity, Innate; Mice; Microscopy, Electron; Neurons; Prions; Protein Binding; Thiazoles | 2010 |
The dissociated form of kappa-casein is the precursor to its amyloid fibril formation.
Topics: Amyloid; Animals; Benzothiazoles; Caseins; Cattle; Disulfides; Hydrogen-Ion Concentration; In Vitro Techniques; Micelles; Microscopy, Electron, Transmission; Molecular Weight; Oxidation-Reduction; Protein Multimerization; Temperature; Thiazoles | 2010 |
Curcumin labeling of neuronal fibrillar tau inclusions in human brain samples.
Topics: Alzheimer Disease; Benzothiazoles; Brain Diseases; Curcumin; Humans; Neurofibrillary Tangles; Neurons; Pick Disease of the Brain; Silver Staining; Supranuclear Palsy, Progressive; tau Proteins; Tauopathies; Thiazoles | 2010 |
Analysis of monomeric Abeta (1-40) peptide by capillary electrophoresis.
Topics: Amyloid beta-Peptides; Benzothiazoles; Electrophoresis, Capillary; Limit of Detection; Peptide Fragments; Spectrophotometry, Ultraviolet; Thiazoles | 2010 |
Alzheimer's disease: spect and pet tracers for beta-amyloid imaging.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Brain Mapping; Cerebral Cortex; Congo Red; Fluorodeoxyglucose F18; Humans; Neurofibrillary Tangles; Positron-Emission Tomography; Protein Binding; Radiopharmaceuticals; Thiazoles; Tomography, Emission-Computed, Single-Photon | 2010 |
Activation of phospholipase A2 by 1-palmitoyl-2-(9'-oxo-nonanoyl)-sn-glycero-3-phosphocholine in vitro.
Topics: Animals; Bee Venoms; Benzothiazoles; Enzyme Activation; Fluorescent Dyes; In Vitro Techniques; Kinetics; Microscopy, Electron, Transmission; Multiprotein Complexes; Oxidative Stress; Phosphatidylcholines; Phospholipases A2; Spectrometry, Fluorescence; Thiazoles | 2010 |
Catechol derivatives inhibit the fibril formation of amyloid-beta peptides.
Topics: Amyloid; Amyloid beta-Peptides; Benzothiazoles; Catechols; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Peptide Fragments; Thiazoles | 2010 |
Molecular basis of inhibition of substrate hydrolysis by a ligand bound to the peripheral site of acetylcholinesterase.
Topics: Acetylcholinesterase; Acetylthiocholine; Animals; Benzothiazoles; Binding, Competitive; Carbachol; Catalytic Domain; Cell Line; Cholinesterase Inhibitors; Crystallography, X-Ray; Humans; Hydrolysis; Kinetics; Ligands; Quaternary Ammonium Compounds; Substrate Specificity; Thiazoles | 2010 |
Superoxide dismutase 1 and tgSOD1 mouse spinal cord seed fibrils, suggesting a propagative cell death mechanism in amyotrophic lateral sclerosis.
Topics: Amyloid; Amyotrophic Lateral Sclerosis; Animals; Benzothiazoles; Cell Death; Humans; Kinetics; Mice; Mice, Transgenic; Microscopy, Electron; Protein Stability; Spinal Cord; Subcellular Fractions; Superoxide Dismutase; Superoxide Dismutase-1; Thiazoles; Time Factors | 2010 |
Dose- and time-dependent alpha-synuclein aggregation induced by ferric iron in SK-N-SH cells.
Topics: alpha-Synuclein; Benzothiazoles; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Ferric Compounds; Humans; Iron; Thiazoles; Time Factors | 2010 |
Bifurcated hydrogen bonds stabilize fibrils of poly(L-glutamic) acid.
Topics: Benzothiazoles; Circular Dichroism; Fluorescent Dyes; Hydrogen Bonding; Polyglutamic Acid; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2010 |
Resveratrol selectively remodels soluble oligomers and fibrils of amyloid Abeta into off-pathway conformers.
Topics: Adrenal Medulla; Amyloid beta-Peptides; Animals; Antioxidants; Benzothiazoles; Epitopes; Microscopy, Atomic Force; Peptides; Protein Binding; Protein Conformation; Protein Folding; Protein Structure, Secondary; Rats; Resveratrol; Silver Staining; Stilbenes; Thiazoles | 2010 |
The role of the lipid bilayer in tau aggregation.
Topics: Benzothiazoles; Fluorescence; Humans; Hydrogen-Ion Concentration; Kinetics; Lipid Bilayers; Peptide Fragments; Protein Binding; Protein Multimerization; Spectrometry, Fluorescence; Static Electricity; tau Proteins; Thiazoles; Unilamellar Liposomes | 2010 |
Substoichiometric inhibition of Abeta(1-40) aggregation by a tandem Abeta(40-1-Gly8-1-40) peptide.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Circular Dichroism; Fluorescent Dyes; Humans; Microscopy, Atomic Force; Peptide Fragments; Peptides; Thiazoles | 2010 |
Three repeat isoforms of tau inhibit assembly of four repeat tau filaments.
Topics: Benzothiazoles; Humans; Kinetics; Protein Binding; Protein Isoforms; Protein Structure, Quaternary; Recombinant Proteins; Repetitive Sequences, Amino Acid; tau Proteins; Thiazoles | 2010 |
Fibrillation of alpha-lactalbumin: effect of crocin and safranal, two natural small molecules from Crocus sativus.
Topics: Amyloid; Animals; Benzothiazoles; Biological Assay; Carotenoids; Cattle; Circular Dichroism; Congo Red; Crocus; Cyclohexenes; Lactalbumin; Microscopy, Atomic Force; Molecular Weight; Particle Size; PC12 Cells; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Spectrometry, Fluorescence; Terpenes; Thiazoles | 2010 |
The amyloid fibrils of the constant domain of immunoglobulin light chain.
Topics: Amyloid; Benzothiazoles; Circular Dichroism; Fluorescence; Humans; Immunoglobulin Constant Regions; Immunoglobulin Light Chains; Protein Structure, Tertiary; Sonication; Thiazoles | 2010 |
Identifying the bond responsible for the fluorescence modulation in an amyloid fibril sensor.
Topics: Amyloid; Benzothiazoles; Fluorescence; Fluorescent Dyes; Molecular Structure; Quantum Theory; Thiazoles | 2010 |
Highly sensitive amyloid detection enabled by thioflavin T dimers.
Topics: Amyloid; Benzothiazoles; Dimerization; Humans; Limit of Detection; Thiazoles | 2010 |
Isolation of short peptide fragments from alpha-synuclein fibril core identifies a residue important for fibril nucleation: a possible implication for diagnostic applications.
Topics: alpha-Synuclein; Amino Acid Sequence; Amyloid; Benzothiazoles; Circular Dichroism; Humans; Insulin; Lewy Bodies; Microscopy, Atomic Force; Molecular Sequence Data; Peptide Fragments; Thiazoles | 2010 |
A beta-amino acid modified heptapeptide containing a designed recognition element disrupts fibrillization of the amyloid beta-peptide.
Topics: Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Animals; Benzothiazoles; Circular Dichroism; Cryoelectron Microscopy; Microscopy, Electron, Transmission; Neurons; Neurotoxins; Oligopeptides; Peptide Fragments; Protein Structure, Secondary; Rats; Spectrometry, Fluorescence; Thiazoles | 2010 |
Protective effects of galantamine against Abeta-induced PC12 cell apoptosis by preventing mitochondrial dysfunction and endoplasmic reticulum stress.
Topics: Amyloid beta-Peptides; Animals; Apoptosis; Apoptosis Regulatory Proteins; Benzimidazoles; Benzothiazoles; Blotting, Western; Calcium; Cell Survival; Coloring Agents; Congo Red; Cytochromes c; Endoplasmic Reticulum; Fluorescent Dyes; Galantamine; Microscopy, Electron; Microscopy, Fluorescence; Mitochondria; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Peptide Fragments; Rats; Reactive Oxygen Species; Thiazoles | 2010 |
Charge transfer process determines ultrafast excited state deactivation of thioflavin T in low-viscosity solvents.
Topics: Absorption; Benzothiazoles; Electron Transport; Kinetics; Models, Molecular; Molecular Conformation; Photochemical Processes; Solvents; Thiazoles; Viscosity | 2010 |
Self-assembling pathway of HiApp fibrils within lipid bilayers.
Topics: Benzothiazoles; Diabetes Mellitus, Type 2; Fluoresceins; Humans; Islet Amyloid Polypeptide; Lipid Bilayers; Microscopy, Atomic Force; Spectrometry, Fluorescence; Thiazoles | 2010 |
Quantifying prefibrillar amyloids in vitro by using a "thioflavin-like" spectroscopic method.
Topics: Amyloid beta-Peptides; Benzothiazoles; Fluorescent Dyes; Models, Molecular; Spectrometry, Fluorescence; Thiazoles; Tryptophan | 2010 |
Granular and lattice deposits in corneal dystrophy caused by R124C mutation of TGFBIp.
Topics: Adult; Amyloid; Antibody Specificity; Arginine; Benzothiazoles; Cornea; Corneal Dystrophies, Hereditary; Corneal Stroma; Cysteine; Extracellular Matrix Proteins; Fluorescent Antibody Technique; Fluorescent Dyes; Genotype; Heterozygote; Humans; Male; Mutation; Penetrance; Staining and Labeling; Thiazoles; Transforming Growth Factor beta | 2010 |
The flavanol (-)-epigallocatechin 3-gallate inhibits amyloid formation by islet amyloid polypeptide, disaggregates amyloid fibrils, and protects cultured cells against IAPP-induced toxicity.
Topics: alpha-Synuclein; Amyloid; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Catechin; Cell Culture Techniques; Diabetes Mellitus, Type 2; Flavonoids; Islet Amyloid Polypeptide; Microscopy, Electron, Transmission; Phenols; Polyphenols; Protease Nexins; Rats; Receptors, Cell Surface; Thiazoles | 2010 |
Attenuated antiaggregation effects of magnetite nanoparticles in cerebrospinal fluid of people with Alzheimer's disease.
Topics: Adult; Aged; Alzheimer Disease; Benzothiazoles; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Female; Fluorescence; Humans; Magnetite Nanoparticles; Male; Nanomedicine; Protein Structure, Quaternary; Thiazoles | 2010 |
Amyloid formation and disaggregation of α-synuclein and its tandem repeat (α-TR).
Topics: alpha-Synuclein; Amyloid; Benzothiazoles; Catechin; Flavanones; Humans; Imidazoles; Imides; Ionic Liquids; Microscopy, Electron, Transmission; Parkinson Disease; Sulfonamides; Tandem Repeat Sequences; Thiazoles | 2010 |
Reduction of hippocampal N-acetyl aspartate level in aged APP(Swe)/PS1(dE9) transgenic mice is associated with degeneration of CA3 pyramidal neurons.
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Benzothiazoles; CA1 Region, Hippocampal; Creatine; Disease Models, Animal; Down-Regulation; Female; Humans; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Transgenic; Nerve Degeneration; Plaque, Amyloid; Presenilin-1; Pyramidal Cells; Thiazoles | 2010 |
Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Animals; Benzothiazoles; Biophysics; Fluorescent Dyes; Humans; Kinetics; Mice; Microelectrodes; Microscopy, Electron, Transmission; Neurons; Patch-Clamp Techniques; Peptide Fragments; Plaque, Amyloid; Protein Binding; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2010 |
Comparative effects of pH and ionic strength on protein-protein interactions, unfolding, and aggregation for IgG1 antibodies.
Topics: Benzothiazoles; Calorimetry, Differential Scanning; Chromatography, Gel; Circular Dichroism; Humans; Hydrogen-Ion Concentration; Immunoglobulin G; Immunoglobulin Isotypes; Kinetics; Lasers; Light; Osmolar Concentration; Protein Binding; Protein Conformation; Protein Unfolding; Scattering, Radiation; Solutions; Spectrometry, Fluorescence; Static Electricity; Temperature; Thiazoles | 2010 |
Protein-induced photophysical changes to the amyloid indicator dye thioflavin T.
Topics: Amyloid; Benzothiazoles; beta 2-Microglobulin; Crystallization; Crystallography; Fluorescence; Fluorescent Dyes; Humans; Protein Structure, Secondary; Thiazoles | 2010 |
Amyloid-binding small molecules efficiently block SEVI (semen-derived enhancer of virus infection)- and semen-mediated enhancement of HIV-1 infection.
Topics: Amyloid; Animals; Benzothiazoles; Cell Line, Tumor; Cells, Cultured; Competitive Bidding; Dose-Response Relationship, Drug; Flow Cytometry; HIV-1; Humans; Jurkat Cells; Kinetics; Male; Molecular Structure; Protein Binding; Semen; Thiazoles; Virion; Virus Attachment | 2010 |
Characterization of the non-fibrillar α-synuclein oligomers.
Topics: alpha-Synuclein; Benzothiazoles; Cell Membrane; Dose-Response Relationship, Drug; Kinetics; Protein Multimerization; Protein Structure, Quaternary; Protein Structure, Secondary; Salts; Solubility; Thiazoles; Unilamellar Liposomes | 2011 |
Immunohistological detection of Chlamydia pneumoniae in the Alzheimer's disease brain.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Brain; Brain Chemistry; Cerebral Cortex; Chlamydia Infections; Chlamydophila pneumoniae; Coloring Agents; Female; Humans; Immunohistochemistry; Male; Neurofibrillary Tangles; Plaque, Amyloid; Reproducibility of Results; Thiazoles; Tissue Banks | 2010 |
Proline periodicity modulates the self-assembly properties of elastin-like polypeptides.
Topics: Amyloid; Benzothiazoles; Elastin; Proline; Protein Multimerization; Protein Structure, Secondary; Thiazoles | 2010 |
The kinetic parameters and energy cost of the Hsp70 chaperone as a polypeptide unfoldase.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Benzothiazoles; Energy Metabolism; Escherichia coli; Fluorescent Dyes; Freezing; Genes, Reporter; HSP70 Heat-Shock Proteins; Kinetics; Luciferases; Molecular Chaperones; Polynucleotide 5'-Hydroxyl-Kinase; Protein Folding; Substrate Specificity; Thiazoles; Urea | 2010 |
Nature of the light radiation which suppresses the mobility of microorganisms endowed with secondary fluorescence in the presence of thioflavin.
Topics: Bacteria; Benzothiazoles; Fluorescence; Radiation Effects; Thiazoles | 1945 |
Fluorescence quantum yield of thioflavin T in rigid isotropic solution and incorporated into the amyloid fibrils.
Topics: Amyloid; Benzothiazoles; Fluorescence; Quantum Theory; Solvents; Temperature; Thiazoles; Viscosity | 2010 |
Interactions between amyloidophilic dyes and their relevance to studies of amyloid inhibitors.
Topics: Amyloid; Benzothiazoles; Coloring Agents; Congo Red; Humans; Light; Particle Size; Quartz Crystal Microbalance Techniques; Scattering, Radiation; Thiazoles | 2010 |
Use of yeast as a system to study amyloid toxicity.
Topics: Amyloid; Benzothiazoles; Centrifugation; Chromatography, Gel; Electrophoresis, Agar Gel; Microbial Viability; Microscopy, Fluorescence; Neurodegenerative Diseases; Organisms, Genetically Modified; Prions; Protein Conformation; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Staining and Labeling; Thiazoles | 2011 |
I32E and V36K double mutation in beta2-sheet abrogates amyloid beta peptide toxicity.
Topics: Alzheimer Disease; Alzheimer Vaccines; Amino Acid Sequence; Amino Acid Substitution; Amyloid beta-Peptides; Animals; Antibody Specificity; Benzothiazoles; Cell Shape; Enzyme-Linked Immunosorbent Assay; Erythrocytes; Humans; Molecular Sequence Data; Mutation; Protein Binding; Rabbits; Thiazoles | 2010 |
Supramolecular capsules: under control.
Topics: Benzothiazoles; Bridged-Ring Compounds; Capsules; Drug Carriers; Imidazoles; Macrocyclic Compounds; Metals; Thiazoles | 2010 |
Novel cell- and tissue-based assays for detecting misfolded and aggregated protein accumulation within aggresomes and inclusion bodies.
Topics: Autophagy; Benzothiazoles; Cell Line, Tumor; Fluorescent Antibody Technique, Indirect; Fluorescent Dyes; Humans; Inclusion Bodies; Leupeptins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Folding; Proteins; Thiazoles; Ubiquitination | 2011 |
Synthesis and biophysical evaluation of arylhydrazono-1H-2-indolinones as β-amyloid aggregation inhibitors.
Topics: Amyloid beta-Peptides; Benzothiazoles; Circular Dichroism; Drug Evaluation, Preclinical; Indoles; Kinetics; Peptide Fragments; Protein Multimerization; Protein Structure, Quaternary; Spectrometry, Fluorescence; Structure-Activity Relationship; Thiazoles | 2011 |
Interactions of Npc1 and amyloid accumulation/deposition in the APP/PS1 mouse model of Alzheimer's.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Disease Models, Animal; Humans; Intracellular Signaling Peptides and Proteins; Mice; Mice, Transgenic; Niemann-Pick C1 Protein; Niemann-Pick Diseases; Peptide Fragments; Plaque, Amyloid; Proteins; Regression Analysis; Thiazoles | 2011 |
Β-amyloid 1-42 oligomers impair function of human embryonic stem cell-derived forebrain cholinergic neurons.
Topics: Amyloid beta-Peptides; Benzothiazoles; Cell Differentiation; Cell Survival; Cholinergic Agents; Electrophysiology; Embryonic Stem Cells; Humans; Immunohistochemistry; Nerve Growth Factor; Neurons; Peptide Fragments; Prosencephalon; Proto-Oncogene Proteins c-akt; Thiazoles | 2010 |
A modified protocol to prepare seed-free starting solutions of amyloid-β (Aβ)₁₋₄₀ and Aβ₁₋₄₂ from the corresponding depsipeptides.
Topics: Amyloid beta-Peptides; Benzothiazoles; Circular Dichroism; Depsipeptides; Peptide Fragments; Solutions; Thiazoles | 2011 |
Nonnative aggregation of an IgG1 antibody in acidic conditions, part 2: nucleation and growth kinetics with competing growth mechanisms.
Topics: Antibodies, Monoclonal; Benzothiazoles; Biopharmaceutics; Calorimetry, Differential Scanning; Chromatography, High Pressure Liquid; Circular Dichroism; Electrophoresis, Capillary; Fluorescent Dyes; Hydrogen-Ion Concentration; Immunoglobulin G; Kinetics; Light; Osmolar Concentration; Protein Binding; Protein Conformation; Protein Multimerization; Protein Stability; Scattering, Radiation; Solubility; Spectrometry, Fluorescence; Thiazoles | 2011 |
Nonnative aggregation of an IgG1 antibody in acidic conditions: part 1. Unfolding, colloidal interactions, and formation of high-molecular-weight aggregates.
Topics: Antibodies, Monoclonal; Benzothiazoles; Biopharmaceutics; Calorimetry, Differential Scanning; Chromatography, High Pressure Liquid; Circular Dichroism; Colloids; Electrophoresis, Capillary; Fluorescent Dyes; Hydrogen-Ion Concentration; Immunoglobulin G; Light; Osmolar Concentration; Protein Binding; Protein Conformation; Protein Multimerization; Protein Stability; Protein Unfolding; Scattering, Radiation; Solubility; Spectrometry, Fluorescence; Thiazoles | 2011 |
Assays for studying nucleated aggregation of polyglutamine proteins.
Topics: Benzothiazoles; Fluorometry; Humans; Huntingtin Protein; Immunoblotting; Kinetics; Microscopy, Electron; Multiprotein Complexes; Nerve Tissue Proteins; Nuclear Proteins; Peptides; Protein Multimerization; Protein Structure, Tertiary; Thiazoles; Ultracentrifugation | 2011 |
The role of the C-terminus of human α-synuclein: intra-disulfide bonds between the C-terminus and other regions stabilize non-fibrillar monomeric isomers.
Topics: alpha-Synuclein; Benzothiazoles; Circular Dichroism; Cysteine; Cystine; Fluorescent Dyes; Humans; Isomerism; Kinetics; Mutagenesis, Site-Directed; Mutant Proteins; Oxidation-Reduction; Parkinson Disease; Protein Denaturation; Protein Folding; Protein Stability; Protein Structure, Secondary; Recombinant Proteins; Spectrometry, Fluorescence; Thiazoles | 2011 |
Both plant and animal LEA proteins act as kinetic stabilisers of polyglutamine-dependent protein aggregation.
Topics: Amino Acid Motifs; Animals; Benzothiazoles; Cell Line; Fluorescent Dyes; Helminth Proteins; Homeostasis; Humans; Kinetics; Microscopy, Confocal; Microscopy, Fluorescence; Molecular Chaperones; Peptides; Plant Proteins; Protein Folding; Recombinant Fusion Proteins; Thiazoles; Triticum; Tylenchida | 2011 |
Electrochemical detection of interaction between Thioflavin T and acetylcholinesterase.
Topics: Acetylcholinesterase; Benzothiazoles; Binding Sites; Carbachol; Cholinesterase Inhibitors; Electrochemical Techniques; Electrodes; Oxidation-Reduction; Paraoxon; Spectrometry, Fluorescence; Thiazoles | 2011 |
High ability of apolipoprotein E4 to stabilize amyloid-β peptide oligomers, the pathological entities responsible for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Apolipoprotein E3; Apolipoprotein E4; Benzothiazoles; Blotting, Western; Electrophoresis; Humans; Spectrophotometry, Infrared; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2011 |
[Thioflavin T interaction with amyloid fibrils as an instrument for their studying].
Topics: Amyloid; Animals; Benzothiazoles; Fluorescence; Fluorescent Dyes; Thiazoles | 2010 |
Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion.
Topics: Benzothiazoles; Biomarkers; Brain; Creutzfeldt-Jakob Syndrome; Fluorescent Dyes; Humans; Motion; Prions; PrPSc Proteins; Sensitivity and Specificity; Thiazoles | 2011 |
Spectroscopic characterization of diverse amyloid fibrils in vitro by the fluorescent dye Nile red.
Topics: Amyloid; Benzothiazoles; Binding Sites; Fluorescence Resonance Energy Transfer; Humans; Hydrogen-Ion Concentration; Kinetics; Microscopy; Muramidase; Oxazines; Prealbumin; Protein Binding; Staining and Labeling; Thiazoles | 2011 |
The Japanese mutant Aβ (ΔE22-Aβ(1-39)) forms fibrils instantaneously, with low-thioflavin T fluorescence: seeding of wild-type Aβ(1-40) into atypical fibrils by ΔE22-Aβ(1-39).
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Benzothiazoles; Binding Sites; Chromatography, Gel; Circular Dichroism; Congo Red; Dimethyl Sulfoxide; Kinetics; Molecular Sequence Data; Mutant Proteins; Mutation; Nuclear Magnetic Resonance, Biomolecular; Peptide Fragments; Protein Multimerization; Protein Structure, Secondary; Spectrometry, Fluorescence; Thiazoles; X-Ray Diffraction | 2011 |
Destruction of amyloid fibrils of keratoepithelin peptides by laser irradiation coupled with amyloid-specific thioflavin T.
Topics: Amyloid; Benzothiazoles; Corneal Dystrophies, Hereditary; Extracellular Matrix Proteins; Humans; Laser Therapy; Lasers; Microscopy, Fluorescence; Peptides; Thiazoles; Transforming Growth Factor beta | 2011 |
Bovine Serum Albumin protofibril-like aggregates formation: solo but not simple mechanism.
Topics: Animals; Benzothiazoles; Cattle; Hydrogen-Ion Concentration; Kinetics; Protein Conformation; Protein Multimerization; Serum Albumin, Bovine; Static Electricity; Temperature; Thermodynamics; Thiazoles; Tryptophan | 2011 |
Biflavonoids are superior to monoflavonoids in inhibiting amyloid-β toxicity and fibrillogenesis via accumulation of nontoxic oligomer-like structures.
Topics: Amyloid; Amyloid beta-Peptides; Apigenin; Benzothiazoles; Biflavonoids; Caspases; Cell Line; Cell Survival; Circular Dichroism; Flavones; Flavonoids; Fluorescent Dyes; Humans; Kinetics; Microscopy, Electron, Transmission; Neurons; Peptide Fragments; Phenols; Polyphenols; Solubility; Thiazoles | 2011 |
Expression of human FUS/TLS in yeast leads to protein aggregation and cytotoxicity, recapitulating key features of FUS proteinopathy.
Topics: Amino Acid Sequence; Amino Acid Substitution; Benzothiazoles; DNA-Binding Proteins; Humans; Mutation; Neurodegenerative Diseases; Protein Structure, Tertiary; Recombinant Proteins; RNA-Binding Protein FUS; Saccharomyces cerevisiae; Sarcosine; Thiazoles | 2011 |
Curcuminoid binds to amyloid-β1-42 oligomer and fibril.
Topics: Amyloid; Amyloid beta-Peptides; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzothiazoles; Curcumin; Dose-Response Relationship, Drug; Fluorescent Dyes; Humans; Microscopy, Electron, Scanning Transmission; Peptide Fragments; Protein Binding; Thiazoles; Time Factors | 2011 |
Sequence-independent control of peptide conformation in liposomal vaccines for targeting protein misfolding diseases.
Topics: Alzheimer Disease; Animals; Benzothiazoles; Circular Dichroism; Female; Humans; Immunoglobulin G; Liposomes; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C57BL; Peptides; Protein Conformation; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Proteostasis Deficiencies; Thiazoles; Vaccines | 2011 |
Heparin binds 8 kDa gelsolin cross-β-sheet oligomers and accelerates amyloidogenesis by hastening fibril extension.
Topics: Amyloid; Benzothiazoles; Chemical Phenomena; Circular Dichroism; Electrophoretic Mobility Shift Assay; Fluorescence Polarization; Fluorescent Dyes; Gelsolin; Glycosaminoglycans; Heparin; Humans; Kinetics; Microscopy, Atomic Force; Nuclear Magnetic Resonance, Biomolecular; Peptide Fragments; Protein Conformation; Protein Interaction Domains and Motifs; Protein Stability; Solubility; Thiazoles | 2011 |
Detecting the early onset of shear-induced fibril formation of insulin in situ.
Topics: Amyloid; Animals; Benzothiazoles; Cattle; Insulin; Microscopy, Electron, Transmission; Principal Component Analysis; Protein Structure, Secondary; Rheology; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Stress, Mechanical; Thiazoles | 2011 |
The effect of tachykinin neuropeptides on amyloid β aggregation.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Fluorescence; Fluorescent Dyes; Humans; Peptide Fragments; Protein Structure, Secondary; Tachykinins; Thiazoles | 2011 |
On the origin of the stronger binding of PIB over thioflavin T to protofibrils of the Alzheimer amyloid-β peptide: a molecular dynamics study.
Topics: Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Binding Sites; Electrons; Fluorescent Dyes; Hydrophobic and Hydrophilic Interactions; Molecular Dynamics Simulation; Protein Structure, Secondary; Protein Subunits; Rotation; Substrate Specificity; Thermodynamics; Thiazoles | 2011 |
Structural evolution of Iowa mutant β-amyloid fibrils from polymorphic to homogeneous states under repeated seeded growth.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Benzothiazoles; Hydrogen-Ion Concentration; Kinetics; Microscopy, Electron, Transmission; Molecular Sequence Data; Mutation; Nuclear Magnetic Resonance, Biomolecular; Protein Conformation; Spectrometry, Fluorescence; Thermodynamics; Thiazoles | 2011 |
Temperature dependence of the fluorescence properties of thioflavin-T in propanol, a glass-forming liquid.
Topics: 1-Propanol; Benzothiazoles; Electric Impedance; Glass; Spectrometry, Fluorescence; Temperature; Thiazoles; Time Factors | 2011 |
Amyloid fibrils formation of concanavalin A at basic pH.
Topics: Amyloid; Benzothiazoles; Concanavalin A; Hydrogen-Ion Concentration; Light; Protein Multimerization; Protein Structure, Secondary; Scattering, Small Angle; Spectrometry, Fluorescence; Temperature; Thiazoles | 2011 |
The regulatory subunit of PKA-I remains partially structured and undergoes β-aggregation upon thermal denaturation.
Topics: Benzothiazoles; Calorimetry, Differential Scanning; Circular Dichroism; Cyclic AMP; Cyclic AMP-Dependent Protein Kinase RIalpha Subunit; Enzyme Stability; Fluorescence; Humans; Light; Microscopy, Atomic Force; Molecular Dynamics Simulation; Protein Denaturation; Protein Structure, Quaternary; Protein Structure, Secondary; Protein Unfolding; Scattering, Radiation; Temperature; Thiazoles | 2011 |
The Osaka FAD mutation E22Δ leads to the formation of a previously unknown type of amyloid β fibrils and modulates Aβ neurotoxicity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Cells, Cultured; Humans; Mutation; Neurons; Neurotoxins; Rats; Thiazoles | 2011 |
A role for amyloid in cell aggregation and biofilm formation.
Topics: Adhesiveness; Amino Acid Sequence; Amyloid; Benzothiazoles; Biofilms; Candida albicans; Cell Adhesion Molecules; Congo Red; Fluorescence; Fungal Proteins; Microbial Viability; Microscopy, Atomic Force; Mutant Proteins; Mutation; Nanostructures; Peptides; Polystyrenes; Saccharomyces cerevisiae; Solubility; Substrate Specificity; Thiazoles | 2011 |
Amyloid-binding small molecule reduces HIV infection.
Topics: Amyloid; Anti-HIV Agents; Benzothiazoles; Drug Design; HIV Infections; HIV-1; Humans; Male; Semen; Thiazoles; Virus Attachment | 2010 |
Kinetic characterization of amyloid-beta 1-42 aggregation with a multimethodological approach.
Topics: Amyloid beta-Peptides; Benzothiazoles; Flavonoids; Kinetics; Microscopy, Atomic Force; Microscopy, Fluorescence; Peptide Fragments; Spectrometry, Fluorescence; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiazoles | 2011 |
Monitoring the aggregation processes of amyloid-β using a spin-labeled, fluorescent nitroxyl radical.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Electron Spin Resonance Spectroscopy; Fluorescent Dyes; Humans; Nitrogen Oxides; Oxidation-Reduction; Spectrometry, Fluorescence; Spin Labels; Thiazoles | 2011 |
Zinc, copper, and carnosine attenuate neurotoxicity of prion fragment PrP106-126.
Topics: Amino Acid Sequence; Animals; Benzothiazoles; Carnosine; Cells, Cultured; Chelating Agents; Circular Dichroism; Copper; Fluorescence; Hippocampus; Microscopy, Atomic Force; Molecular Sequence Data; Neurons; Neurotoxins; Peptides; Prions; Protein Conformation; Rats; Thiazoles; Trace Elements; Zinc | 2011 |
Coumarin 6 and 1,6-diphenyl-1,3,5-hexatriene (DPH) as fluorescent probes to monitor protein aggregation.
Topics: alpha-Synuclein; Benzothiazoles; Carbonic Anhydrases; Coumarins; Diphenylhexatriene; Fluorescent Dyes; Proteins; Quantum Theory; Spectrometry, Fluorescence; Thiazoles | 2011 |
Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan.
Topics: Aging; Amyloid; Amyloid beta-Peptides; Animals; Autophagy; Benzothiazoles; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Curcumin; DNA-Binding Proteins; Dose-Response Relationship, Drug; Forkhead Transcription Factors; Homeostasis; Humans; Longevity; Molecular Chaperones; Paralysis; Phenotype; Proteasome Endopeptidase Complex; Protein Binding; Proteins; Survival Analysis; Thiazoles; Transcription Factors | 2011 |
Acetonitrile can promote formation of different structural intermediate states on aggregation pathway of immunoglobulin G from human and bovine.
Topics: Acetonitriles; Animals; Benzothiazoles; Cattle; Circular Dichroism; Fluorescence; Humans; Immunoglobulin G; Protein Conformation; Protein Denaturation; Protein Folding; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2011 |
Calcium ions promote formation of amyloid β-peptide (1-40) oligomers causally implicated in neuronal toxicity of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Blotting, Western; Calcium; Fluorescence; Humans; Ions; Models, Biological; Mutant Proteins; Neurons; Protein Structure, Quaternary; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2011 |
Mechanically functional amyloid fibrils in the adhesive of a marine invertebrate as revealed by Raman spectroscopy and atomic force microscopy.
Topics: alpha-Synuclein; Amyloid; Animals; Benzothiazoles; Humans; Microscopy, Atomic Force; Platyhelminths; Protein Structure, Secondary; Spectrum Analysis, Raman; Thiazoles | 2009 |
Influence of protein hydrolysis on the growth kinetics of β-lg fibrils.
Topics: Benzothiazoles; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Lactoglobulins; Models, Chemical; Peptide Fragments; Protein Multimerization; Protein Structure, Quaternary; Temperature; Thiazoles | 2011 |
A new look at old compounds.
Topics: Aging; Animals; Benzothiazoles; Disease; Fluorescent Dyes; Homeostasis; Humans; Proteins; Thiazoles | 2011 |
Non-esterified fatty acids generate distinct low-molecular weight amyloid-β (Aβ42) oligomers along pathway different from fibril formation.
Topics: Amyloid beta-Peptides; Benzothiazoles; Blotting, Western; Circular Dichroism; Fatty Acids, Nonesterified; Fluorescence; Guanidine; Micelles; Models, Biological; Molecular Weight; Protein Denaturation; Protein Structure, Quaternary; Protein Structure, Secondary; Thermodynamics; Thiazoles | 2011 |
Cerebral amyloid angiopathy in streptozotocin rat model of sporadic Alzheimer's disease: a long-term follow up study.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antibiotics, Antineoplastic; Benzothiazoles; Cerebral Amyloid Angiopathy; Disease Models, Animal; Disease Progression; Longitudinal Studies; Male; Peptide Fragments; Rats; Rats, Wistar; Staining and Labeling; Streptozocin; Thiazoles | 2011 |
Probing the mechanism of insulin aggregation during agitation.
Topics: Benzothiazoles; Circular Dichroism; Electrophoresis, Polyacrylamide Gel; Excipients; Hypoglycemic Agents; Insulin; Kinetics; Particle Size; Protein Denaturation; Proteins; Spectrometry, Fluorescence; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiazoles | 2011 |
The effect of red pigment on the amyloidization of yeast proteins.
Topics: Amyloid; Benzothiazoles; Down-Regulation; Molecular Sequence Data; Pigments, Biological; Protein Binding; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiazoles | 2011 |
Hybrid hydrogels self-assembled from graft copolymers containing complementary β-sheets as hydroxyapatite nucleation scaffolds.
Topics: Acrylamides; Amino Acid Sequence; Animals; Benzothiazoles; Bone Regeneration; Calcification, Physiologic; Cell Adhesion; Cell Line; Cell Proliferation; Cell Survival; Circular Dichroism; Congo Red; Elasticity; Hydrogels; Hydroxyapatites; Mice; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Molecular Structure; Oligopeptides; Osteoblasts; Peptides; Protein Structure, Secondary; Rheology; Spectrometry, Fluorescence; Spectrometry, X-Ray Emission; Spectroscopy, Fourier Transform Infrared; Thiazoles; Tissue Scaffolds | 2011 |
Seed-dependent deposition behavior of Aβ peptides studied with wireless quartz-crystal-microbalance biosensor.
Topics: Amyloid beta-Peptides; Antibodies; Benzothiazoles; Biosensing Techniques; Hydrogen-Ion Concentration; Microscopy, Atomic Force; Peptide Fragments; Protein Binding; Quartz Crystal Microbalance Techniques; Spectrometry, Fluorescence; Thiazoles; Wireless Technology | 2011 |
A standardized and biocompatible preparation of aggregate-free amyloid beta peptide for biophysical and biological studies of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Biomedical Research; Cell Line, Tumor; Cytological Techniques; Humans; Indicators and Reagents; Kinetics; Microscopy, Electron, Transmission; Nuclear Magnetic Resonance, Biomolecular; Reproducibility of Results; Solubility; Spectrometry, Fluorescence; Thiazoles | 2011 |
Hexafluoroisopropanol induces amyloid fibrils of islet amyloid polypeptide by enhancing both hydrophobic and electrostatic interactions.
Topics: Amyloid; Benzothiazoles; Humans; Hydrogen-Ion Concentration; Islet Amyloid Polypeptide; Propanols; Protein Structure, Quaternary; Static Electricity; Thiazoles | 2011 |
Design and evaluation of a 6-mer amyloid-beta protein derived phage display library for molecular targeting of amyloid plaques in Alzheimer's disease: Comparison with two cyclic heptapeptides derived from a randomized phage display library.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Benzothiazoles; Biotinylation; Blood-Brain Barrier; Contrast Media; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Humans; Kinetics; Magnetic Resonance Imaging; Mice; Mice, Transgenic; Models, Molecular; Molecular Sequence Data; Molecular Targeted Therapy; Mutagenesis, Site-Directed; Peptide Fragments; Peptide Library; Peptides, Cyclic; Plaque, Amyloid; Protein Binding; Sequence Analysis, DNA; Thiazoles | 2011 |
Pressure effect on the nonradiative process of thioflavin-T.
Topics: 1-Butanol; 1-Propanol; Benzothiazoles; Fluorescence; Molecular Structure; Pentanols; Pressure; Thiazoles; Time Factors; Viscosity | 2011 |
A nano-confined charged layer defies the principle of electrostatic interaction.
Topics: Benzothiazoles; Biomimetic Materials; Dioctyl Sulfosuccinic Acid; Fatty Alcohols; Micelles; Nanostructures; Quaternary Ammonium Compounds; Static Electricity; Surface Properties; Thiazoles | 2011 |
Study of thioflavin-T immobilized in porous silicon and the effect of different organic vapors on the fluorescence lifetime.
Topics: Benzothiazoles; Fluorescence; Microscopy, Electron, Scanning; Silicon; Surface Properties; Thiazoles | 2011 |
Resolution of localized small molecule-Aβ interactions by deep-ultraviolet resonance Raman spectroscopy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Circular Dichroism; Flavonoids; Humans; Peptide Fragments; Protein Binding; Protein Structure, Secondary; Spectrum Analysis, Raman; Thiazoles | 2011 |
Amyloid histology stain for rapid bacterial endospore imaging.
Topics: Bacillus; Bacterial Proteins; Bacteriological Techniques; Benzothiazoles; Geobacillus stearothermophilus; Image Processing, Computer-Assisted; Microscopy, Fluorescence; Spores, Bacterial; Staining and Labeling; Thiazoles | 2011 |
Role of oligomers in the amyloidogenesis of primary cutaneous amyloidosis.
Topics: Amyloidogenic Proteins; Amyloidosis; Antibody Specificity; Benzothiazoles; Birefringence; Cell Membrane; Coloring Agents; Congo Red; Dermis; Eosine Yellowish-(YS); Epidermis; Female; Fibroblasts; Hematoxylin; Humans; Macrophages; Male; Microscopy, Polarization; Models, Biological; Oligopeptides; Protein Conformation; Protein Folding; Skin Diseases; Staining and Labeling; Thiazoles | 2011 |
Mechanism of amyloid β-protein aggregation mediated by GM1 ganglioside clusters.
Topics: Amyloid beta-Peptides; Animals; Benzothiazoles; Cattle; Circular Dichroism; G(M1) Ganglioside; Kinetics; Models, Biological; Protein Binding; Protein Stability; Protein Structure, Quaternary; Protein Structure, Secondary; Temperature; Thiazoles | 2011 |
Modeling the nonradiative decay rate of electronically excited thioflavin T.
Topics: Benzothiazoles; Electrons; Molecular Structure; Quantum Theory; Thiazoles | 2011 |
Cucurbit[n]uril based supramolecular assemblies: tunable physico-chemical properties and their prospects.
Topics: Benzothiazoles; Fluorescent Dyes; Kinetics; Macrocyclic Compounds; Metals; Photobleaching; Porphyrins; Thiazoles | 2011 |
Diagnostics for amyloid fibril formation: where to begin?
Topics: Amyloid; Benzothiazoles; Birefringence; Centrifugation; Chromatography, Gel; Congo Red; Kinetics; Protein Multimerization; Protein Structure, Secondary; Spectrum Analysis; Thiazoles | 2011 |
D-Ser-containing humanin shows promotion of fibril formation.
Topics: Alzheimer Disease; Amino Acid Sequence; Benzothiazoles; Circular Dichroism; Congo Red; Humans; Intracellular Signaling Peptides and Proteins; Molecular Sequence Data; Neuroprotective Agents; Protein Structure, Secondary; Solutions; Stereoisomerism; Structure-Activity Relationship; Thiazoles | 2012 |
Lack of LDL receptor enhances amyloid deposition and decreases glial response in an Alzheimer's disease mouse model.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Apolipoproteins E; Astrocytes; Benzothiazoles; Disease Models, Animal; Hippocampus; Humans; Mice; Mice, Transgenic; Microglia; Neuroglia; Plaque, Amyloid; Protein Processing, Post-Translational; Receptors, LDL; Thiazoles | 2011 |
Targeting vascular amyloid in arterioles of Alzheimer disease transgenic mice with amyloid β protein antibody-coated nanoparticles.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Arterioles; Benzothiazoles; Disease Models, Animal; Ferric Compounds; Humans; Immunoglobulin G; Magnetic Resonance Imaging; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Nanoparticles; Peptide Fragments; Plaque, Amyloid; Platelet Endothelial Cell Adhesion Molecule-1; Thiazoles | 2011 |
Inhibition of amyloid β aggregation and cytotoxicity by photodegradation using a designed fullerene derivative.
Topics: Amyloid beta-Peptides; Animals; Benzothiazoles; Fullerenes; PC12 Cells; Peptide Fragments; Photolysis; Rats; Spectrometry, Fluorescence; Thiazoles | 2011 |
Chiral superstructures of insulin amyloid fibrils.
Topics: Amyloid; Benzothiazoles; Birefringence; Circular Dichroism; Insulin; Protein Folding; Protein Multimerization; Thiazoles | 2011 |
Conformational changes during amyloid fibril formation of pancreatic thiol proteinase inhibitor: effect of copper and zinc.
Topics: Amyloid; Animals; Benzothiazoles; Circular Dichroism; Cysteine Proteinase Inhibitors; Goats; Hydrogen-Ion Concentration; Microscopy, Electron, Transmission; Nucleic Acid Denaturation; Pancreas; Protein Conformation; Spectrometry, Fluorescence; Thiazoles; Trifluoroethanol | 2012 |
Ligand polarizability contributes to tau fibril binding affinity.
Topics: Alzheimer Disease; Benzothiazoles; Binding Sites; Humans; Indoles; Ligands; Oxindoles; Phenothiazines; Protein Binding; tau Proteins; Thiazoles | 2011 |
Human apolipoprotein A-I-derived amyloid: its association with atherosclerosis.
Topics: Amyloid; Anilino Naphthalenesulfonates; Animals; Apolipoprotein A-I; Atherosclerosis; Benzothiazoles; CHO Cells; Cholesterol; Cricetinae; Cricetulus; Heparin; Humans; Hydrogen-Ion Concentration; Hypochlorous Acid; Matrix Metalloproteinase 12; Neutrophil Activation; Oxidation-Reduction; Protein Binding; Protein Folding; Protein Stability; Protein Structure, Quaternary; Protein Structure, Secondary; Proteolysis; Solvents; Tetradecanoylphorbol Acetate; Thiazoles; Tryptophan | 2011 |
Protein L-isoaspartyl O-methyltransferase inhibits amyloid beta fibrillogenesis in vitro.
Topics: Amyloid beta-Peptides; Benzothiazoles; Blotting, Western; Circular Dichroism; Escherichia coli; Fluorescent Dyes; Humans; Microscopy, Electron, Transmission; Molecular Weight; Plaque, Amyloid; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Protein Structure, Secondary; Thiazoles | 2011 |
A novel mutation in transforming growth factor-beta induced protein (TGFβIp) reveals secondary structure perturbation in lattice corneal dystrophy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amino Acid Sequence; Amyloid; Asian People; Benzothiazoles; Bowman Membrane; Child; Circular Dichroism; Contrast Sensitivity; Corneal Dystrophies, Hereditary; Corneal Stroma; Crystallography, X-Ray; Extracellular Matrix Proteins; Female; Humans; Male; Middle Aged; Molecular Sequence Data; Mutation; Polymerase Chain Reaction; Refraction, Ocular; Thiazoles; Transforming Growth Factor beta; Visual Acuity | 2011 |
Existence of different structural intermediates and aggregates on the folding pathway of ovalbumin.
Topics: Anilino Naphthalenesulfonates; Animals; Benzothiazoles; Dose-Response Relationship, Drug; Glucose; Glycation End Products, Advanced; Guanidine; Ovalbumin; Protein Denaturation; Protein Folding; Spectrum Analysis; Thiazoles; Time Factors | 2012 |
Designed hairpin peptides interfere with amyloidogenesis pathways: fibril formation and cytotoxicity inhibition, interception of the preamyloid state.
Topics: alpha-Synuclein; Amino Acid Sequence; Amyloid; Animals; Benzothiazoles; Drug Design; Humans; In Vitro Techniques; Islet Amyloid Polypeptide; Microscopy, Electron, Transmission; Models, Biological; Models, Molecular; Molecular Sequence Data; Peptides; Protein Folding; Protein Multimerization; Rats; Recombinant Proteins; Thiazoles | 2011 |
Synthesis and evaluation of ferrocenoyl pentapeptide (Fc-KLVFF) as an inhibitor of Alzheimer's Aβ₁-₄₂ fibril formation in vitro.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Drug Design; Drug Evaluation, Preclinical; Electrochemical Techniques; Ferric Compounds; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Molecular Targeted Therapy; Nootropic Agents; Oligopeptides; Oxidation-Reduction; Peptide Fragments; Peptides; Solubility; Thiazoles | 2011 |
Molecular interaction of TPPP with PrP antagonized the CytoPrP-induced disruption of microtubule structures and cytotoxicity.
Topics: Amino Acid Sequence; Amyloid; Animals; Benzothiazoles; Blotting, Western; Brain; Cell Line, Tumor; Cell Survival; Cricetinae; Cytosol; HeLa Cells; Humans; Immunoprecipitation; Mesocricetus; Microscopy, Confocal; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Microtubules; Molecular Sequence Data; Nerve Tissue Proteins; Peptide Fragments; Prions; Protein Binding; Scrapie; Thiazoles | 2011 |
Interaction of thioflavin T with amyloid fibrils: stoichiometry and affinity of dye binding, absorption spectra of bound dye.
Topics: Absorption; Amyloid; Benzothiazoles; Binding Sites; Fluorescent Dyes; Protein Binding; Thiazoles; Water | 2011 |
Evaluation of aluminium, manganese, copper and selenium effects on human islets amyloid polypeptide hormone aggregation.
Topics: Aluminum; Benzothiazoles; Copper; Humans; Islet Amyloid Polypeptide; Manganese; Selenium; Thiazoles | 2011 |
Oligonucleotide-based label-free Hg2+ assay with a monomer-excimer fluorescence switch.
Topics: Benzothiazoles; Hydrogen-Ion Concentration; Mercury; Oligonucleotides; Spectrometry, Fluorescence; Thiazoles | 2011 |
Thioflavin T forms a non-fluorescent complex with α-helical poly-L-glutamic acid.
Topics: Amyloid; Benzothiazoles; Circular Dichroism; Hydrogen-Ion Concentration; Polyglutamic Acid; Protein Structure, Secondary; Spectrophotometry; Temperature; Thiazoles | 2011 |
Delineation of the core aggregation sequences of TDP-43 C-terminal fragment.
Topics: Amino Acid Sequence; Benzothiazoles; DNA-Binding Proteins; Light; Peptides; Protein Binding; Protein Structure, Tertiary; Recombinant Proteins; Scattering, Radiation; Thiazoles | 2011 |
Dual conformation of H2H3 domain of prion protein in mammalian cells.
Topics: Amyloid; Animals; Benzothiazoles; Cell Line; Glycosylation; Glycosylphosphatidylinositols; Prions; Protein Folding; Protein Multimerization; Protein Structure, Tertiary; Rabbits; Thiazoles | 2011 |
Inflammation protein SAA2.2 spontaneously forms marginally stable amyloid fibrils at physiological temperature.
Topics: Amyloid; Amyloidosis; Animals; Benzothiazoles; Electrophoresis, Polyacrylamide Gel; Mice; Protein Binding; Protein Stability; Protein Structure, Secondary; Serum Amyloid A Protein; Temperature; Thiazoles | 2011 |
Crocetin inhibits beta-amyloid fibrillization and stabilizes beta-amyloid oligomers.
Topics: Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Carotenoids; Fluorescence; Humans; Molecular Sequence Data; Thiazoles; Vitamin A | 2011 |
A screening tool for therapeutic monoclonal antibodies: Identifying the most stable protein and its best formulation based on thioflavin T binding.
Topics: Antibodies, Monoclonal; Benzothiazoles; Chemistry, Pharmaceutical; Chromatography, Gel; Fluorescent Dyes; Protein Folding; Protein Stability; Proteins; Thiazoles | 2012 |
Self assembly of human septin 2 into amyloid filaments.
Topics: Amyloid; Benzothiazoles; Circular Dichroism; Humans; Microscopy, Electron, Transmission; Protein Binding; Protein Structure, Tertiary; Septins; Thiazoles | 2012 |
Prefibrillar aggregates of yeast prion Sup35NM and its variant are toxic to mammalian cells.
Topics: Animals; Annexin A5; Apoptosis; Benzothiazoles; Caspases; Cell Line, Transformed; Chlorocebus aethiops; Epithelial Cells; Flow Cytometry; Microscopy, Electron, Transmission; Peptide Termination Factors; Propidium; Protein Binding; Saccharomyces cerevisiae Proteins; Thiazoles; Yeasts | 2011 |
Inhibition of amyloid peptide fragment Aβ25-35 fibrillogenesis and toxicity by N-terminal β-amino acid-containing esapeptides: is taurine moiety essential for in vivo effects?
Topics: Amino Acids; Amyloid beta-Peptides; Benzothiazoles; Cell Line, Tumor; Cell Survival; Circular Dichroism; Humans; Peptide Fragments; Peptides; Protein Binding; Protein Structure, Secondary; Superoxides; Taurine; Thiazoles | 2012 |
Testing the therapeutic potential of doxycycline in a Drosophila melanogaster model of Alzheimer disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Anti-Bacterial Agents; Benzothiazoles; Caspase 3; Cell Line, Tumor; Disease Models, Animal; Doxycycline; Drosophila melanogaster; Fluorescent Dyes; Humans; Longevity; Thiazoles | 2011 |
Prion protein polymerisation triggered by manganese-generated prion protein seeds.
Topics: Alleles; Animals; Benzothiazoles; Blotting, Western; Catalysis; Chickens; Hydrogen-Ion Concentration; Manganese; Microscopy, Electron; Mutation; Polymerization; Polymorphism, Genetic; Prions; Recombinant Proteins; Scrapie; Sheep; Thiazoles | 2012 |
Characterization, amyloid formation, and immobilization of a novel SGNH hydrolase from Listeria innocua 11262.
Topics: Amino Acid Sequence; Amyloid; Benzothiazoles; Carboxylic Ester Hydrolases; Catalysis; Chromatography, Gel; Circular Dichroism; Cross-Linking Reagents; Enzymes, Immobilized; Escherichia coli; Hydrolysis; Listeria; Models, Molecular; Molecular Sequence Data; Mutation; Nitrophenols; Sequence Homology, Amino Acid; Spectrometry, Fluorescence; Thiazoles | 2012 |
Sensory network dysfunction, behavioral impairments, and their reversibility in an Alzheimer's β-amyloidosis mouse model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloidosis; Animals; Behavioral Symptoms; Benzoates; Benzothiazoles; Benzylamines; Brain Waves; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Enzyme-Linked Immunosorbent Assay; Fourier Analysis; Habituation, Psychophysiologic; Humans; Mice; Mice, Transgenic; Odorants; Olfactory Pathways; Sensation Disorders; Smell; Thiazoles | 2011 |
Interference of low-molecular substances with the thioflavin-T fluorescence assay of amyloid fibrils.
Topics: Amyloid; Amyloid beta-Peptides; Azure Stains; Benzothiazoles; Biological Assay; Diabetes Mellitus, Type 2; False Positive Reactions; Fluorescent Dyes; Humans; Insulin; Kinetics; Neurodegenerative Diseases; Protein Structure, Secondary; Spectrometry, Fluorescence; Tannins; Thiazoles | 2012 |
Solid-state NMR reveals differences in the packing arrangements of peptide aggregates derived from the aortic amyloid polypeptide medin.
Topics: Amino Acid Sequence; Amyloid; Amyloidosis; Antigens, Surface; Aorta; Benzothiazoles; Biomarkers; Diabetes Mellitus, Type 2; Humans; Magnetic Resonance Spectroscopy; Microscopy, Electron; Milk Proteins; Molecular Sequence Data; Neurodegenerative Diseases; Peptide Fragments; Protein Structure, Secondary; Protein Structure, Tertiary; Spectrometry, Fluorescence; Thiazoles | 2012 |
Effect of melatonin on α-synuclein self-assembly and cytotoxicity.
Topics: alpha-Synuclein; Analysis of Variance; Animals; Antioxidants; Antiparkinson Agents; Benzothiazoles; Brain; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Melatonin; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Neurons; Protein Structure, Secondary; Sincalide; Thiazoles; Time Factors; Trihexyphenidyl | 2012 |
Aβ(39-42) modulates Aβ oligomerization but not fibril formation.
Topics: Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Humans; Microscopy, Fluorescence; Molecular Dynamics Simulation; Molecular Sequence Data; PC12 Cells; Peptide Fragments; Protein Multimerization; Rats; Spectrometry, Fluorescence; Spectrometry, Mass, Electrospray Ionization; Thiazoles | 2012 |
The mechanism of enhanced insulin amyloid fibril formation by NaCl is better explained by a conformational change model.
Topics: Amyloid; Benzothiazoles; Chromatography, Gel; Circular Dichroism; Crystallography, X-Ray; Humans; Insulin; Kinetics; Models, Molecular; Protein Conformation; Sodium Chloride; Thiazoles | 2011 |
Inhibiting effect of α(s1)-casein on Aβ(1-40) fibrillogenesis.
Topics: Amyloid; Amyloid beta-Peptides; Benzothiazoles; Caseins; Circular Dichroism; Hydrodynamics; Light; Microscopy, Atomic Force; Particle Size; Peptide Fragments; Protein Structure, Quaternary; Scattering, Radiation; Spectrometry, Fluorescence; Thiazoles; Time Factors | 2012 |
The effect of nanoparticles on amyloid aggregation depends on the protein stability and intrinsic aggregation rate.
Topics: Acrylamides; Amyloid; Benzothiazoles; Fluorescence; Hydrogen Bonding; Nanoparticles; Plant Proteins; Protein Stability; Thiazoles; Vinyl Compounds | 2012 |
Modulation of pathway of insulin fibrillation by a small molecule helix inducer 2,2,2-trifluoroethanol.
Topics: Amyloid; Animals; Benzothiazoles; Cattle; Circular Dichroism; Hydrodynamics; Hydrogen-Ion Concentration; Insulin; Kinetics; Light; Particle Size; Protein Structure, Quaternary; Protein Structure, Secondary; Scattering, Radiation; Solutions; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Temperature; Thiazoles; Time Factors; Trifluoroethanol | 2012 |
[The effect of red pigment of Saccharomyces cerevisiae on insulin fibril formation in vitro].
Topics: Amyloid; Animals; Benzothiazoles; Biomimetic Materials; Fluorescence; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Hydrolysis; Insulin; Microscopy, Electron; Microscopy, Electron, Transmission; Pigments, Biological; Prion Diseases; Saccharomyces cerevisiae; Solutions; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiazoles | 2011 |
Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro.
Topics: Amyloid beta-Peptides; Analysis of Variance; Animals; Antioxidants; Arachidonic Acids; Benzothiazoles; Cannabinoids; Cell Line, Tumor; Cell Survival; Chromans; Drug Interactions; Gene Expression Regulation; Humans; Hydrogen Peroxide; Indoles; Lipid Peroxidation; Microscopy, Electron, Transmission; Neuroblastoma; Oxidative Stress; PC12 Cells; Peptide Fragments; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Thiazoles | 2012 |
A label-free oligonucleotide based thioflavin-T fluorescent switch for Ag+ detection with low background emission.
Topics: Benzothiazoles; Fluorescence; Fluorescent Dyes; Oligonucleotides; Silver; Spectrometry, Fluorescence; Thiazoles | 2012 |
Morin hydrate inhibits amyloid formation by islet amyloid polypeptide and disaggregates amyloid fibers.
Topics: Amyloid; Benzothiazoles; Flavonoids; Humans; Islet Amyloid Polypeptide; Kaempferols; Light; Microscopy, Electron, Transmission; Quercetin; Scattering, Radiation; Thiazoles | 2012 |
Hexafluoroisopropanol induces self-assembly of β-amyloid peptides into highly ordered nanostructures.
Topics: Amyloid beta-Peptides; Benzothiazoles; Circular Dichroism; Fluorescent Dyes; Humans; Microscopy, Atomic Force; Microscopy, Electron, Scanning; Nanostructures; Particle Size; Peptide Fragments; Propanols; Protein Multimerization; Protein Structure, Quaternary; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2012 |
SDS can be utilized as an amyloid inducer: a case study on diverse proteins.
Topics: Amyloid; Animals; Benzothiazoles; Circular Dichroism; Fluorescence; Humans; Hydrogen-Ion Concentration; Isoelectric Point; Light; Models, Biological; Nephelometry and Turbidimetry; Protein Binding; Protein Structure, Secondary; Proteins; Scattering, Radiation; Sodium Dodecyl Sulfate; Spectrum Analysis; Thiazoles | 2012 |
Early detection of insulin fibrillation: a fluorescence lifetime assay to probe the pre-fibrillar regime.
Topics: Benzothiazoles; Fluorescent Dyes; Humans; Insulin; Protein Multimerization; Protein Structure, Quaternary; Solutions; Spectrometry, Fluorescence; Thiazoles; Time Factors | 2012 |
Interaction of thioflavin T with amyloid fibrils: fluorescence quantum yield of bound dye.
Topics: Amyloid; Benzothiazoles; Fluorescence; Fluorescent Dyes; Quantum Theory; Thiazoles | 2012 |
Role of the helical structure of the N-terminal region of Plasmodium falciparum merozoite surface protein 2 in fibril formation and membrane interaction.
Topics: Amyloid; Animals; Antigens, Protozoan; Benzothiazoles; Circular Dichroism; Hydrogen-Ion Concentration; Kinetics; Lipid Bilayers; Magnetic Resonance Spectroscopy; Micelles; Microscopy, Electron, Transmission; Molecular Conformation; Plasmodium falciparum; Protein Conformation; Protein Structure, Tertiary; Protozoan Proteins; Spectrophotometry; Temperature; Thiazoles | 2012 |
Analyzing thioflavin T binding to amyloid fibrils by an equilibrium microdialysis-based technique.
Topics: Amyloid; Benzothiazoles; Binding Sites; Coloring Agents; Fluorescent Dyes; Humans; Insulin; Kinetics; Ligands; Microdialysis; Models, Statistical; Protein Binding; Regression Analysis; Spectrometry, Fluorescence; Spectrophotometry; Thiazoles; Time Factors | 2012 |
Using graphene oxide high near-infrared absorbance for photothermal treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid; Animals; Benzothiazoles; Cell Survival; Graphite; Humans; Hyperthermia, Induced; Mice; Nanostructures; Oxides; PC12 Cells; Phototherapy; Rats; Thiazoles | 2012 |
Short polyglutamine peptide forms a high-affinity binding site for thioflavin-T at the N-terminus.
Topics: Amino Acid Motifs; Benzothiazoles; Binding Sites; Models, Molecular; Peptides; Protein Multimerization; Thiazoles | 2012 |
Optimization of potent hepatitis C virus NS3 helicase inhibitors isolated from the yellow dyes thioflavine S and primuline.
Topics: Animals; Antiviral Agents; Benzothiazoles; Blood Proteins; Cell Line, Tumor; Coloring Agents; Hepacivirus; Humans; Mice; Polymers; Protein Binding; Replicon; RNA Helicases; RNA, Viral; Solubility; Structure-Activity Relationship; Thiazoles; Viral Nonstructural Proteins; Virus Replication | 2012 |
Separation and detection of individual Aβ aggregates by capillary electrophoresis with laser-induced fluorescence detection.
Topics: Amyloid beta-Peptides; Benzothiazoles; Electrophoresis, Capillary; Lasers; Microscopy, Electron, Scanning Transmission; Peptide Fragments; Spectrophotometry, Ultraviolet; Thiazoles | 2012 |
Naphthoquinone-tyrptophan reduces neurotoxic Aβ*56 levels and improves cognition in Alzheimer's disease animal model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Benzothiazoles; Blood-Brain Barrier; Brain Chemistry; Cognition; Drosophila; Fluorescent Dyes; Humans; Longevity; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Models, Molecular; Motor Activity; Naphthalenes; Neurofibrils; Neuroprotective Agents; Psychomotor Performance; Recognition, Psychology; Thiazoles; Tryptophan | 2012 |
Ultrafast molecular rotor: an efficient sensor for premelting of natural DNA.
Topics: Benzothiazoles; Circular Dichroism; DNA; Nucleic Acid Conformation; Nucleic Acid Denaturation; Spectrophotometry, Ultraviolet; Thiazoles; Transition Temperature | 2012 |
Inhibition of aggregation of amyloid β42 by arginine-containing small compounds.
Topics: Amyloid; Amyloid beta-Peptides; Arginine; Benzothiazoles; Coumarins; Dipeptides; Electrophoresis, Polyacrylamide Gel; Humans; Peptide Fragments; Polymerization; Protein Binding; Small Molecule Libraries; Solubility; Solutions; Thiazoles | 2012 |
An FT-IR study on packing defects in mixed β-aggregates of poly(L-glutamic acid) and poly(D-glutamic acid): a high-pressure rescue from a kinetic trap.
Topics: Benzothiazoles; Hydrogen Bonding; Hydrogen-Ion Concentration; Kinetics; Polyglutamic Acid; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared; Temperature; Thermodynamics; Thiazoles | 2012 |
Binding of the three-repeat domain of tau to phospholipid membranes induces an aggregated-like state of the protein.
Topics: Alzheimer Disease; Amino Acid Sequence; Benzothiazoles; Biophysics; Circular Dichroism; Humans; Lipid Bilayers; Lipids; Liposomes; Lysine; Magnetic Resonance Spectroscopy; Methylation; Molecular Sequence Data; Phosphatidylcholines; Phosphatidylserines; Phospholipids; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Static Electricity; tau Proteins; Thiazoles; Unilamellar Liposomes | 2012 |
Establishing the links between Aβ aggregation and cytotoxicity in vitro using biophysical approaches.
Topics: Amyloid beta-Peptides; Animals; Benzothiazoles; Biological Assay; Biophysical Phenomena; Cell Survival; Humans; L-Lactate Dehydrogenase; Microscopy, Electron, Transmission; Models, Molecular; Neurons; PC12 Cells; Peptide Fragments; Protein Multimerization; Protein Structure, Secondary; Rats; Thiazoles | 2012 |
Analysis of S100 oligomers and amyloids.
Topics: Amyloid; Apoproteins; Benzothiazoles; Brain; Humans; Light; Metals; Protein Multimerization; Protein Structure, Secondary; S100 Proteins; Scattering, Radiation; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2012 |
S100A8/A9 amyloidosis in the ageing prostate: relating ex vivo and in vitro studies.
Topics: Aging; Amyloid; Benzothiazoles; Blotting, Western; Calgranulin A; Calgranulin B; Chromatography, Liquid; Humans; Male; Prostate; Protein Multimerization; Protein Structure, Secondary; Spectrometry, Mass, Electrospray Ionization; Staining and Labeling; Thiazoles | 2012 |
Histological staining of amyloid and pre-amyloid peptides and proteins in mouse tissue.
Topics: Amyloid beta-Peptides; Animals; Antibodies, Monoclonal; Benzothiazoles; Coloring Agents; Congo Red; Humans; Immunohistochemistry; Islet Amyloid Polypeptide; Mice; Perfusion; Staining and Labeling; tau Proteins; Thiazoles | 2012 |
Identification and characterization of an aβ oligomer precipitating peptide that may be useful to explore gene therapeutic approaches to Alzheimer disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Line, Tumor; Centrifugation, Density Gradient; Disease Models, Animal; Genetic Therapy; Humans; Mice; Nephelometry and Turbidimetry; Neurons; Peptides; Sequence Analysis, DNA; Thiazoles | 2012 |
Detection of α-synuclein aggregates by fluorescence microscopy.
Topics: alpha-Synuclein; Benzothiazoles; Biomarkers; Circular Dichroism; Dopaminergic Neurons; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Models, Biological; Neurodegenerative Diseases; Parkinson Disease; Recombinant Proteins; Surface Properties; Temperature; Thiazoles | 2012 |
The preventive effect of garlicin on a porcine model of myocardial infarction reperfusion no-reflow.
Topics: Allyl Compounds; Animals; Benzothiazoles; Cardiotonic Agents; Contrast Media; Disease Models, Animal; Disulfides; Hemodynamics; Male; Myocardial Infarction; Myocardial Reperfusion; No-Reflow Phenomenon; Swine; Swine, Miniature; Thiazoles; Ultrasonography | 2014 |
Biocompatibility of mannan nanogel--safe interaction with plasma proteins.
Topics: Amyloid beta-Peptides; Antigen-Presenting Cells; Apolipoprotein A-I; Benzothiazoles; beta 2-Microglobulin; Blood Coagulation; Blood Proteins; Chromatography, Gel; Circular Dichroism; Humans; Mannans; Materials Testing; Nanogels; Polyethylene Glycols; Polyethyleneimine; Serum Albumin; Spectrometry, Fluorescence; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiazoles; Thrombin | 2012 |
The contrasting effect of macromolecular crowding on amyloid fibril formation.
Topics: Amyloid; Animals; Benzothiazoles; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Models, Molecular; Muramidase; Peptide Fragments; Phosphorylation; Polymers; Prions; Protein Multimerization; Protein Structure, Secondary; Rabbits; tau Proteins; Thiazoles | 2012 |
Inhibitory effect of curcumin on the Al(III)-induced Aβ₄₂ aggregation and neurotoxicity in vitro.
Topics: Aluminum; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Circular Dichroism; Curcumin; Microscopy, Atomic Force; Neurotoxicity Syndromes; PC12 Cells; Peptide Fragments; Rats; Thiazoles | 2012 |
Anti-amyloidogenic effects of soybean isoflavones in vitro: Fluorescence spectroscopy demonstrating direct binding to Aβ monomers, oligomers and fibrils.
Topics: Amyloid beta-Peptides; Benzothiazoles; Glycine max; Humans; Isoflavones; Microscopy, Atomic Force; Microscopy, Electron; Peptide Fragments; Spectrometry, Fluorescence; Thiazoles | 2012 |
A new trend in the experimental methodology for the analysis of the thioflavin T binding to amyloid fibrils.
Topics: Absorption; Acetylcholinesterase; Amyloid; Amyloid beta-Peptides; Animals; Benzothiazoles; Biochemistry; Electrophorus; Insulin; Microdialysis; Peptide Fragments; Protein Binding; Quantum Theory; Solutions; Spectrometry, Fluorescence; Thiazoles | 2012 |
Laser-induced liquid bead ion desorption mass spectrometry: an approach to precisely monitor the oligomerization of the β-amyloid peptide.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Benzothiazoles; Humans; Hydrogen-Ion Concentration; Kinetics; Lasers; Mass Spectrometry; Molecular Sequence Data; Peptide Fragments; Protein Multimerization; Protein Structure, Secondary; Small Molecule Libraries; Spectrometry, Fluorescence; Thiazoles | 2012 |
Amyloid-like fibril formation by tachykinin neuropeptides and its relevance to amyloid β-protein aggregation and toxicity.
Topics: Algorithms; Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Cell Line, Tumor; Circular Dichroism; Congo Red; Heparin; Humans; Kassinin; Microscopy, Electron; Neurons; Peptide Fragments; Physalaemin; Protein Binding; Protein Structure, Secondary; Substance P; Thiazoles; Toxicity Tests | 2012 |
Dissecting the role of disulfide bonds on the amyloid formation of insulin.
Topics: Alkylation; Amino Acid Sequence; Amyloid; Animals; Benzothiazoles; Cells, Cultured; Circular Dichroism; Disulfides; Erythrocytes; Hemolysis; Humans; Insulin; Molecular Sequence Data; Swine; Thiazoles; Ultraviolet Rays | 2012 |
Degradation of fungal prion HET-s(218-289) induces formation of a generic amyloid fold.
Topics: Amino Acid Sequence; Amyloid; Animals; Benzothiazoles; Electrophoresis, Polyacrylamide Gel; Fluorescence; Fungal Proteins; Hydrogen-Ion Concentration; Mass Spectrometry; Molecular Sequence Data; Podospora; Prions; Protein Binding; Proteolysis; Thiazoles; X-Ray Diffraction | 2012 |
Trifluoroethanol and acetonitrile induced formation of the molten globule states and aggregates of cellulase.
Topics: Acetonitriles; Aspergillus niger; Benzothiazoles; Biomimetics; Cellulase; Circular Dichroism; Congo Red; Protein Conformation; Protein Multimerization; Spectroscopy, Fourier Transform Infrared; Thiazoles; Trifluoroethanol | 2012 |
PEGylated nanoparticles bind to and alter amyloid-beta peptide conformation: toward engineering of functional nanomedicines for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Bioengineering; Complement Activation; Electrophoresis, Capillary; Humans; In Vitro Techniques; Models, Molecular; Molecular Dynamics Simulation; Nanomedicine; Nanoparticles; Nanotechnology; Peptide Fragments; Polyethylene Glycols; Protein Binding; Protein Conformation; Surface Plasmon Resonance; Thiazoles | 2012 |
Doped diamond-like carbon coatings for surgical instruments reduce protein and prion-amyloid biofouling and improve subsequent cleaning.
Topics: Amyloid; Animals; Benzothiazoles; Biofouling; Carbon; Creutzfeldt-Jakob Syndrome; Decontamination; Diamond; Equipment Contamination; Fluorescent Dyes; Humans; Iatrogenic Disease; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Prions; Stainless Steel; Surgical Instruments; Thiazoles | 2012 |
Fibril-forming motifs are essential and sufficient for the fibrillization of human Tau.
Topics: Amino Acid Motifs; Amyloid; Benzothiazoles; Circular Dichroism; DNA Primers; Humans; Microscopy, Electron, Transmission; Plasmids; Protein Folding; Recombinant Proteins; tau Proteins; Thiazoles | 2012 |
Mutant p53 aggregates into prion-like amyloid oligomers and fibrils: implications for cancer.
Topics: Amino Acid Substitution; Amyloid; Benzothiazoles; Humans; Mutation, Missense; Neoplasms; Prions; Protein Multimerization; Protein Structure, Quaternary; Protein Structure, Secondary; Thiazoles; Tumor Suppressor Protein p53; X-Ray Diffraction | 2012 |
Characterization of semisynthetic and naturally Nα-acetylated α-synuclein in vitro and in intact cells: implications for aggregation and cellular properties of α-synuclein.
Topics: Acetylation; alpha-Synuclein; Animals; Benzothiazoles; Escherichia coli; HEK293 Cells; HeLa Cells; Humans; Mice; Mice, Knockout; Multiprotein Complexes; Parkinson Disease; Protein Binding; Protein Structure, Secondary; Saccharomyces cerevisiae; Thiazoles | 2012 |
The butter flavorant, diacetyl, exacerbates β-amyloid cytotoxicity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Blood-Brain Barrier; Butter; Cell Line; Cell Survival; Circular Dichroism; Diacetyl; Dogs; Flavoring Agents; Fluorescent Dyes; Humans; Lactoylglutathione Lyase; Madin Darby Canine Kidney Cells; Peptide Fragments; Permeability; Protein Conformation; Thiazoles | 2012 |
Cross-seeding effects of amyloid β-protein and α-synuclein.
Topics: alpha-Synuclein; Amyloid beta-Peptides; Animals; Benzothiazoles; Chromatography, Gel; Humans; Microscopy, Electron, Scanning; Peptide Fragments; Plaque, Amyloid; Protein Binding; Thiazoles | 2012 |
Surface chemistry at the nanometer scale influences insulin aggregation.
Topics: Adsorption; Benzothiazoles; Coated Materials, Biocompatible; Fluorescent Dyes; Glass; Humans; Hydrophobic and Hydrophilic Interactions; Insulin; Kinetics; Microscopy, Atomic Force; Nanostructures; Protein Structure, Secondary; Recombinant Proteins; Silanes; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Surface Properties; Thiazoles | 2012 |
Effects of peptides derived from terminal modifications of the aβ central hydrophobic core on aβ fibrillization.
Topics: Amyloid; Amyloid beta-Peptides; Benzothiazoles; Cell Line, Tumor; Chromatography, High Pressure Liquid; Circular Dichroism; Drug Design; Fluorescence; Fluorescent Dyes; Humans; Indicators and Reagents; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Peptides; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship; Surface Plasmon Resonance; Thiazoles | 2010 |
Dual effect of amino modified polystyrene nanoparticles on amyloid β protein fibrillation.
Topics: Amyloid; Amyloid beta-Peptides; Benzothiazoles; Drug Delivery Systems; Fluorescent Dyes; Fluorometry; Humans; Microscopy, Electron; Nanoparticles; Negative Staining; Nephelometry and Turbidimetry; Peptide Fragments; Polystyrenes; Recombinant Proteins; Surface Properties; Thiazoles | 2010 |
Rhodanine and thiohydantoin derivatives for detecting tau pathology in Alzheimer's brains.
Topics: Alzheimer Disease; Animals; Autoradiography; Benzothiazoles; Brain; Humans; Iodine Radioisotopes; Mice; Neurofibrillary Tangles; Positron-Emission Tomography; Radiopharmaceuticals; Recombinant Proteins; Rhodanine; Tauopathies; Thiazoles; Thiohydantoins; Tissue Distribution | 2011 |
Binding modes of thioflavin T molecules to prion peptide assemblies identified by using scanning tunneling microscopy.
Topics: Benzothiazoles; Microscopy, Scanning Tunneling; Prions; Protein Binding; Thiazoles | 2011 |
Efficient access to highly pure β-amyloid peptide by optimized solid-phase synthesis.
Topics: Amino Acids; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Chromatography, High Pressure Liquid; Dimethyl Sulfoxide; Fluorenes; Fluorescent Dyes; Humans; Solid-Phase Synthesis Techniques; Solubility; Solvents; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiazoles | 2012 |
Small molecules that protect against β-amyloid-induced cytotoxicity by inhibiting aggregation of β-amyloid.
Topics: Amyloid beta-Peptides; Animals; Benzene Derivatives; Benzothiazoles; Cells, Cultured; Coumaric Acids; Curcumin; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred ICR; Molecular Structure; Molecular Weight; Peptide Fragments; Resveratrol; Stilbenes; Thiazoles | 2012 |
A safe, blood-brain barrier permeable triphenylmethane dye inhibits amyloid-β neurotoxicity by generating nontoxic aggregates.
Topics: Amyloid beta-Peptides; Benzothiazoles; Blood-Brain Barrier; Cell Survival; Dose-Response Relationship, Drug; Fluorescent Dyes; Humans; Microscopy, Electron, Transmission; Nerve Fibers; Neuroprotective Agents; Oxazines; Protein Binding; Rosaniline Dyes; Thiazoles; Trityl Compounds; Xanthenes | 2011 |
Thioflavin-S staining coupled to flow cytometry. A screening tool to detect in vivo protein aggregation.
Topics: Amyloid; Benzothiazoles; Flow Cytometry; Inclusion Bodies; Protein Binding; Proteins; Thiazoles | 2012 |
First-order rate-determining aggregation mechanism of p53 and its implications.
Topics: Benzothiazoles; Binding Sites; Cross-Linking Reagents; Edetic Acid; Humans; Kinetics; Light; Mutation; Protein Denaturation; Protein Folding; Protein Structure, Tertiary; Scattering, Radiation; Temperature; Thiazoles; Tumor Suppressor Protein p53 | 2012 |
Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition.
Topics: Amyloid; Benzothiazoles; Humans; Kinetics; Ligands; Light; Microscopy, Electron; Mutation; Neoplasms; Protein Binding; Protein Conformation; Protein Denaturation; Protein Folding; Scattering, Radiation; Thiazoles; Tumor Suppressor Protein p53 | 2012 |
Interaction between amyloid-β pathology and cortical functional columnar organization.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Benzothiazoles; Brain Mapping; Disease Models, Animal; Electron Transport Complex IV; Humans; Mice; Mice, Transgenic; Models, Neurological; Mutation; Neural Pathways; Plaque, Amyloid; Presenilin-1; Somatosensory Cortex; Thiazoles | 2012 |
Distinguishing crystal-like amyloid fibrils and glass-like amorphous aggregates from their kinetics of formation.
Topics: Amyloid; Anilino Naphthalenesulfonates; Benzothiazoles; beta 2-Microglobulin; Escherichia coli; Fluorescence; Humans; Hydrogen-Ion Concentration; Kinetics; Microscopy, Electron; Protein Conformation; Protein Folding; Proteostasis Deficiencies; Sodium Chloride; Thiazoles; Ultrasonics | 2012 |
Overall sulfation of heparan sulfate from pancreatic islet β-TC3 cells increases maximal fibril formation but does not determine binding to the amyloidogenic peptide islet amyloid polypeptide.
Topics: Amyloid; Animals; Benzothiazoles; Carbohydrate Conformation; Cell Line; Chromatography, Gel; Culture Media, Conditioned; Fluorescent Dyes; Heparin Lyase; Heparitin Sulfate; Humans; Immobilized Proteins; Insulin-Secreting Cells; Islet Amyloid Polypeptide; Mice; Nitrous Acid; Polysaccharide-Lyases; Protein Binding; Protein Multimerization; Proteoglycans; Thiazoles | 2012 |
Unzipping the role of chirality in nanoscale self-assembly of tripeptide hydrogels.
Topics: Benzothiazoles; Dipeptides; Hydrogels; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Nanostructures; Protein Binding; Protein Structure, Secondary; Stereoisomerism; Thiazoles | 2012 |
In situ monitoring Alzheimer's disease β-amyloid aggregation and screening of Aβ inhibitors using a perylene probe.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Cations; DNA, Single-Stranded; Enzyme-Linked Immunosorbent Assay; Fluorescent Dyes; Humans; Kinetics; Microscopy, Atomic Force; Models, Chemical; Peptide Fragments; Perylene; Protein Binding; Spectrophotometry, Ultraviolet; Surface Plasmon Resonance; Thiazoles | 2013 |
A novel inhibitor of amyloid β (Aβ) peptide aggregation: from high throughput screening to efficacy in an animal model of Alzheimer disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Benzothiazoles; Chemistry, Pharmaceutical; Drosophila melanogaster; Drug Design; Drug Evaluation, Preclinical; Green Fluorescent Proteins; Humans; Indoles; Models, Chemical; Peptide Fragments; Peptides; Reactive Oxygen Species; Thiazoles | 2012 |
Molecular plasticity regulates oligomerization and cytotoxicity of the multipeptide-length amyloid-β peptide pool.
Topics: Alzheimer Disease; Amino Acid Motifs; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Cell Line; Cell Survival; Fluorescent Dyes; Humans; Kinetics; Microscopy, Atomic Force; Peptide Fragments; Protein Multimerization; Protein Structure, Quaternary; Thiazoles | 2012 |
The small heat shock proteins αB-crystallin and Hsp27 suppress SOD1 aggregation in vitro.
Topics: alpha-Crystallin B Chain; Amino Acid Substitution; Benzothiazoles; HSP27 Heat-Shock Proteins; Humans; Spectrometry, Fluorescence; Superoxide Dismutase; Superoxide Dismutase-1; Thiazoles | 2013 |
Fibrillation properties of human α₁-acid glycoprotein.
Topics: Amyloid; Benzothiazoles; Congo Red; Disulfides; Flocculation; Humans; Hydrogen-Ion Concentration; Kinetics; Microscopy, Electron, Transmission; Molecular Dynamics Simulation; Orosomucoid; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2013 |
Alternative pathways of human islet amyloid polypeptide aggregation distinguished by (19)f nuclear magnetic resonance-detected kinetics of monomer consumption.
Topics: Benzothiazoles; Catechin; Circular Dichroism; Fluorine; Humans; Islet Amyloid Polypeptide; Kinetics; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Spectrometry, Fluorescence; Thiazoles | 2012 |
The N-methylated peptide SEN304 powerfully inhibits Aβ(1-42) toxicity by perturbing oligomer formation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Survival; Circular Dichroism; Humans; Long-Term Potentiation; Male; Mice; Neurons; Oligopeptides; Peptide Fragments; Protein Multimerization; Protein Structure, Quaternary; Rats; Surface Plasmon Resonance; Thiazoles; Tumor Cells, Cultured | 2012 |
Effects of intravenous immunoglobulin on alpha synuclein aggregation and neurotoxicity.
Topics: alpha-Synuclein; Benzothiazoles; Cell Line, Tumor; Humans; Immunoglobulins, Intravenous; Microscopy, Electron, Transmission; Neuroblastoma; Neurons; Protein Binding; Protein Conformation; Thiazoles | 2012 |
Monoclonal antibodies against large oval aggregates of Aβ1-42.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Antibodies, Monoclonal; Antibody Specificity; Benzothiazoles; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Epitope Mapping; Humans; Mice; Microscopy, Atomic Force; Peptide Fragments; Protein Structure, Secondary; Thiazoles | 2013 |
Influence of the valine zipper region on the structure and aggregation of the basic leucine zipper (bZIP) domain of activating transcription factor 5 (ATF5).
Topics: Activating Transcription Factors; Benzothiazoles; Circular Dichroism; Fluorescence; Humans; Leucine Zippers; Mutation; Nuclear Magnetic Resonance, Biomolecular; Protein Multimerization; Protein Structure, Secondary; Protein Structure, Tertiary; Spectroscopy, Fourier Transform Infrared; Thiazoles; Valine | 2012 |
Effect of nanocavities on the torsional dynamics of thioflavin T in various non-aqueous reverse micelles.
Topics: Benzothiazoles; Micelles; Molecular Dynamics Simulation; Molecular Structure; Nanostructures; Photochemical Processes; Thiazoles | 2013 |
S100A6 amyloid fibril formation is calcium-modulated and enhances superoxide dismutase-1 (SOD1) aggregation.
Topics: Amyloid; Amyotrophic Lateral Sclerosis; Benzothiazoles; Calcium; Cell Cycle Proteins; Cell Line, Tumor; Humans; Kinetics; Protein Structure, Quaternary; Protein Structure, Secondary; S100 Calcium Binding Protein A6; S100 Proteins; Spectroscopy, Fourier Transform Infrared; Superoxide Dismutase; Superoxide Dismutase-1; Thiazoles | 2012 |
Functional amyloid formation by Streptococcus mutans.
Topics: Adhesins, Bacterial; Amyloid; Benzothiazoles; Biofilms; Congo Red; Microscopy, Electron, Transmission; Staining and Labeling; Streptococcus mutans; Thiazoles | 2012 |
Heme binding site in apomyoglobin may be effectively targeted with small molecules to control aggregation.
Topics: Amyloid; Animals; Apoproteins; Benzothiazoles; Binding Sites; Cell Survival; Flavonoids; Fluorescent Dyes; Heme; Horses; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kinetics; Light; Molecular Docking Simulation; Myoglobin; Oxazines; Particle Size; PC12 Cells; Protein Binding; Protein Multimerization; Protein Structure, Quaternary; Rats; Scattering, Radiation; Thiazoles | 2013 |
A peptide binding to the β-site of APP improves spatial memory and attenuates Aβ burden in Alzheimer's disease transgenic mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Benzothiazoles; Cell Line, Tumor; Enzyme-Linked Immunosorbent Assay; Humans; Maze Learning; Memory; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Peptide Library; Peptides; Protein Binding; Protein Structure, Tertiary; Sequence Analysis, DNA; Spatial Behavior; Tetrazolium Salts; Thiazoles | 2012 |
Macromolecular crowding modulates the kinetics and morphology of amyloid self-assembly by β-lactoglobulin.
Topics: Amyloid; Animals; Benzothiazoles; Cattle; Congo Red; Fluorescent Dyes; Guanidine; Hydrogen-Ion Concentration; Kinetics; Lactoglobulins; Microscopy, Electron, Transmission; Protein Multimerization; Protein Structure, Quaternary; Thiazoles | 2013 |
Conformational analysis of thioflavin T bound to the surface of amyloid fibrils.
Topics: Amyloid; Benzothiazoles; Humans; Insulin; Models, Molecular; Protein Binding; Protein Multimerization; Protein Structure, Secondary; Surface Properties; Thiazoles | 2012 |
Rational design of potent domain antibody inhibitors of amyloid fibril assembly.
Topics: alpha-Synuclein; Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Chromatography, Gel; Circular Dichroism; Cloning, Molecular; Drug Design; Electrophoresis, Polyacrylamide Gel; Fluorescence; Humans; Immunoblotting; Islet Amyloid Polypeptide; Microscopy, Atomic Force; Molecular Sequence Data; Protein Engineering; Single-Domain Antibodies; Thiazoles | 2012 |
Temperature and viscosity dependence of the nonradiative decay rates of auramine-O and thioflavin-T in glass-forming solvents.
Topics: Benzophenoneidum; Benzothiazoles; Glass; Molecular Structure; Pentanols; Solvents; Temperature; Thiazoles; Viscosity | 2012 |
Human anti-Aβ IgGs target conformational epitopes on synthetic dimer assemblies and the AD brain-derived peptide.
Topics: Aged; Amyloid beta-Peptides; Benzothiazoles; Biophysics; Brain; Circular Dichroism; Dementia; Dimerization; Electrophoresis, Polyacrylamide Gel; Epitopes; Female; Humans; Immunoglobulins; Immunoglobulins, Intravenous; Microscopy, Electron; Middle Aged; Peptides; Protein Conformation; Sodium Dodecyl Sulfate; Thiazoles | 2012 |
Thioflavin T as an efficient inducer and selective fluorescent sensor for the human telomeric G-quadruplex DNA.
Topics: Base Sequence; Benzothiazoles; Fluorescent Dyes; G-Quadruplexes; Humans; Models, Molecular; Molecular Structure; Telomere; Thiazoles | 2013 |
(-)-Epicatechin gallate prevents alkali-salt mediated fibrillogenesis of hen egg white lysozyme.
Topics: Alkalies; Animals; Benzothiazoles; Catechin; Chickens; Circular Dichroism; Guanosine Triphosphate; Hydrogen-Ion Concentration; Kinetics; Microscopy, Fluorescence; Muramidase; Nephelometry and Turbidimetry; Protein Structure, Secondary; Salts; Thiazoles; Time Factors; Tryptophan | 2013 |
Amyloid-β(1-42) protofibrils formed in modified artificial cerebrospinal fluid bind and activate microglia.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Benzothiazoles; Cerebrospinal Fluid; Chromatography, Gel; Culture Media; Enzyme-Linked Immunosorbent Assay; Fluorescent Dyes; Macrophage Activation; Mice; Microglia; Microscopy, Electron; Peptide Fragments; Quinolines; Thiazoles; Tumor Necrosis Factor-alpha | 2013 |
Modeling amyloids in bacteria.
Topics: Amyloid; Bacteria; Benzothiazoles; Inclusion Bodies; Microscopy, Fluorescence; Models, Biological; Prions; Thiazoles | 2012 |
Surface plasmon resonance imaging of amyloid-β aggregation kinetics in the presence of epigallocatechin gallate and metals.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Catechin; Copper; Ferric Compounds; Humans; Ions; Kinetics; Metals; Microscopy, Electron, Transmission; Peptide Fragments; Surface Plasmon Resonance; Thiazoles; Zinc | 2013 |
Mouse prion protein polymorphism Phe-108/Val-189 affects the kinetics of fibril formation and the response to seeding: evidence for a two-step nucleation polymerization mechanism.
Topics: Alleles; Animals; Benzothiazoles; Circular Dichroism; Dose-Response Relationship, Drug; Kinetics; Mice; Microscopy, Electron; Phenylalanine; Polymers; Polymorphism, Genetic; Prion Diseases; Prions; Protein Conformation; Recombinant Proteins; Thiazoles; Time Factors; Valine | 2013 |
Thioflavine-T and Congo Red reveal the polymorphism of insulin amyloid fibrils when probed by polarization-resolved fluorescence microscopy.
Topics: Amyloid; Animals; Benzothiazoles; Cattle; Circular Dichroism; Congo Red; Fluorescence Polarization; Insulin; Microscopy, Fluorescence; Protein Structure, Secondary; Thiazoles | 2013 |
IAPP aggregation and cellular toxicity are inhibited by 1,2,3,4,6-penta-O-galloyl-β-D-glucose.
Topics: Animals; Benzothiazoles; Cell Survival; Gallic Acid; Humans; Hydrolyzable Tannins; Islet Amyloid Polypeptide; Microscopy, Atomic Force; PC12 Cells; Rats; Spectrometry, Fluorescence; Tannins; Thiazoles | 2013 |
Deciphering structural intermediates and genotoxic fibrillar aggregates of albumins: a molecular mechanism underlying for degenerative diseases.
Topics: Acetonitriles; Albumins; Benzothiazoles; Circular Dichroism; Congo Red; Humans; Lymphocytes; Microscopy, Electron, Scanning; Neurodegenerative Diseases; Ovalbumin; Protein Structure, Secondary; Sodium Chloride; Spectroscopy, Fourier Transform Infrared; Thiazoles; X-Ray Diffraction | 2013 |
Simultaneous measurement of amyloid fibril formation by dynamic light scattering and fluorescence reveals complex aggregation kinetics.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Fluorescence; Humans; Huntington Disease; Kinetics; Light; Parkinson Disease; Particle Size; Protein Structure, Secondary; Thiazoles | 2013 |
Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms.
Topics: alpha-Macroglobulins; Amino Acid Substitution; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Fluorescent Dyes; Humans; Kinetics; Muramidase; Peptide Fragments; Protein Multimerization; Thiazoles; Trypsin | 2013 |
Amyloid fiber formation by synthetic peptides derived from the sequence of the protein CsgA of Escherichia coli.
Topics: Amino Acid Sequence; Amyloid; Benzothiazoles; Escherichia coli; Escherichia coli Proteins; Microscopy, Polarization; Molecular Sequence Data; Peptides; Thiazoles | 2013 |
An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloidogenic Proteins; Animals; Benzothiazoles; Caenorhabditis elegans; Hippocampus; Mice; Mice, Inbred C57BL; Models, Biological; Neurodegenerative Diseases; Neurons; Peptides; Prions; Protein Binding; Protein Structure, Tertiary; Surface Plasmon Resonance; Synapses; Thiazoles | 2013 |
Potassium and ionic strength effects on the conformational and thermal stability of two aldehyde dehydrogenases reveal structural and functional roles of K⁺-binding sites.
Topics: Bacterial Proteins; Benzothiazoles; Betaine-Aldehyde Dehydrogenase; Binding Sites; Cations, Monovalent; Enzyme Stability; Hot Temperature; Models, Molecular; Osmolar Concentration; Plant Proteins; Potassium; Protein Folding; Protein Multimerization; Protein Structure, Secondary; Protein Structure, Tertiary; Pseudomonas aeruginosa; Recombinant Proteins; Spinacia oleracea; Tetraethylammonium; Thiazoles | 2013 |
Dynamic staining of Bacillus endospores with Thioflavin T.
Topics: Bacillus; Bacillus thuringiensis; Benzothiazoles; Fluorescent Dyes; Microscopy, Fluorescence; Species Specificity; Spores, Bacterial; Staining and Labeling; Thiazoles | 2012 |
The truncated C-terminal RNA recognition motif of TDP-43 protein plays a key role in forming proteinaceous aggregates.
Topics: Amino Acid Motifs; Amyloidogenic Proteins; Amyotrophic Lateral Sclerosis; Benzothiazoles; Chromatography; Circular Dichroism; Dimerization; DNA-Binding Proteins; DNA, Complementary; Frontotemporal Lobar Degeneration; Glutathione Transferase; Glycine; Humans; Neurodegenerative Diseases; Peptides; Protein Binding; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Scattering, Radiation; Thiazoles; X-Rays | 2013 |
Bisphenol A accelerates toxic amyloid formation of human islet amyloid polypeptide: a possible link between bisphenol A exposure and type 2 diabetes.
Topics: Air Pollutants, Occupational; Amino Acid Sequence; Animals; Benzhydryl Compounds; Benzothiazoles; Cell Line, Tumor; Cell Membrane; Circular Dichroism; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Humans; Insulin-Secreting Cells; Islet Amyloid Polypeptide; Microscopy, Electron, Transmission; Molecular Sequence Annotation; Oxidative Stress; Phenols; Protein Folding; Protein Structure, Secondary; Rats; Thiazoles | 2013 |
Triggering of inflammasome by aggregated α-synuclein, an inflammatory response in synucleinopathies.
Topics: alpha-Synuclein; Analysis of Variance; Benzothiazoles; Blotting, Western; Carrier Proteins; Chromatography, Reverse-Phase; DNA Primers; Humans; Inflammasomes; Inflammation; Interleukin-1beta; Lewy Bodies; Microscopy, Atomic Force; Microscopy, Confocal; Microscopy, Electron, Transmission; Neurons; NLR Family, Pyrin Domain-Containing 3 Protein; Parkinson Disease; Phagocytosis; Real-Time Polymerase Chain Reaction; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Thiazoles; Toll-Like Receptor 2 | 2013 |
Pt(II) compounds interplay with Cu(II) and Zn(II) coordination to the amyloid-β peptide has metal specific consequences on deleterious processes associated to Alzheimer's disease.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Benzothiazoles; Coordination Complexes; Copper; Humans; Hydrogen-Ion Concentration; Molecular Sequence Data; Platinum; Spectrometry, Fluorescence; Thiazoles; Zinc | 2013 |
Quantitative analysis of the time course of Aβ oligomerization and subsequent growth steps using tetramethylrhodamine-labeled Aβ.
Topics: Amyloid; Amyloid beta-Peptides; Benzothiazoles; Circular Dichroism; Computer Simulation; Fluorescence; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Peptide Fragments; Protein Multimerization; Protein Structure, Quaternary; Rhodamines; Staining and Labeling; Temperature; Thiazoles; Time Factors | 2013 |
The natural product betulinic acid rapidly promotes amyloid-β fibril formation at the expense of soluble oligomers.
Topics: Amyloid beta-Peptides; Benzothiazoles; Betulinic Acid; Chromatography, Gel; Circular Dichroism; Electrophoresis, Polyacrylamide Gel; Fluorescent Dyes; Humans; In Vitro Techniques; Nephelometry and Turbidimetry; Pentacyclic Triterpenes; Spectrometry, Fluorescence; Thiazoles; Triterpenes | 2012 |
Why and how protein aggregation has to be studied in vivo.
Topics: Amyloid; Benzothiazoles; Humans; Magnetic Resonance Spectroscopy; Molecular Chaperones; Neurodegenerative Diseases; Peptide Hydrolases; Proteins; Recombinant Fusion Proteins; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2013 |
Age-related oxidative modifications of transthyretin modulate its amyloidogenicity.
Topics: Age Factors; Aging; Amyloid; Amyloidosis; Benzothiazoles; Cell Line; Humans; Myocytes, Cardiac; Oxidation-Reduction; Point Mutation; Prealbumin; Protein Carbonylation; Protein Multimerization; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Proteins; Resveratrol; Stilbenes; Thiazoles | 2013 |
Molecular mechanism of tau aggregation induced by anionic and cationic dyes.
Topics: Anions; Benzothiazoles; Cations; Cell Line; Coloring Agents; Congo Red; Electrochemistry; Flow Cytometry; Humans; Immunohistochemistry; Lysine; Methylene Blue; Microscopy, Electron; Models, Molecular; Organic Chemicals; Protein Binding; Protein Structure, Secondary; Solubility; tau Proteins; Thermodynamics; Thiazoles | 2013 |
Exploring the multifunctionality of thioflavin- and deferiprone-based molecules as acetylcholinesterase inhibitors for potential application in Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Benzothiazoles; Binding, Competitive; Blood-Brain Barrier; Catalytic Domain; Cell Survival; Cholinesterase Inhibitors; Deferiprone; Humans; Kinetics; Ligands; Models, Molecular; Molecular Docking Simulation; Molecular Structure; Permeability; Prodrugs; Protein Binding; Pyridones; Thiazoles | 2013 |
Peptide concentration alters intermediate species in amyloid β fibrillation kinetics.
Topics: Amyloid beta-Peptides; Benzothiazoles; Fluorescence; Humans; Kinetics; Microscopy, Electron, Transmission; Peptide Fragments; Peptides; Protein Conformation; Recombinant Proteins; Spectrometry, Fluorescence; Thiazoles | 2013 |
Elevated amyloid-β plaque deposition in dietary selenium-deficient Tg2576 transgenic mice.
Topics: Animals; Benzothiazoles; Brain; Diet; Feeding Behavior; Female; Fluorescence; Image Processing, Computer-Assisted; Mice; Mice, Transgenic; Plaque, Amyloid; Selenium; Thiazoles; Tissue Distribution | 2013 |
Thioflavin T and its photoirradiative derivatives: exploring their spectroscopic properties in the absence and presence of amyloid fibrils.
Topics: Amyloid; Benzothiazoles; Chromatography, High Pressure Liquid; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Photochemical Processes; Thiazoles; Ultraviolet Rays | 2013 |
Polyanion induced circular dichroism of Thioflavin T.
Topics: Benzothiazoles; Binding Sites; Circular Dichroism; Fluorescent Dyes; Heparin; Molecular Conformation; Polyelectrolytes; Polymers; Thiazoles | 2013 |
Self-assembling nanomaterials: monitoring the formation of amyloid fibrils, with a focus on small-angle X-ray scattering.
Topics: Amyloid; Animals; Benzothiazoles; Fluorescent Dyes; Humans; Nephelometry and Turbidimetry; Protein Multimerization; Scattering, Small Angle; Spectrometry, Fluorescence; Thiazoles; X-Ray Diffraction | 2013 |
Fine mapping of the amyloid β-protein binding site on myelin basic protein.
Topics: Alanine; Amyloid beta-Peptides; Benzothiazoles; Binding Sites; Humans; Magnetic Resonance Spectroscopy; Microscopy, Electron, Transmission; Mutagenesis, Site-Directed; Myelin Basic Protein; Peptide Fragments; Thiazoles | 2013 |
Time resolved photoelectron spectroscopy of thioflavin T photoisomerization: a simulation study.
Topics: Benzothiazoles; Isomerism; Models, Molecular; Molecular Conformation; Photochemical Processes; Photoelectron Spectroscopy; Spectrometry, Fluorescence; Thiazoles; Time Factors | 2013 |
Mechanism of an ATP-independent protein disaggregase: I. structure of a membrane protein aggregate reveals a mechanism of recognition by its chaperone.
Topics: Amino Acid Sequence; Arabidopsis; Arabidopsis Proteins; Benzothiazoles; Fluorescent Dyes; Hydrophobic and Hydrophilic Interactions; Light; Light-Harvesting Protein Complexes; Micelles; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Models, Molecular; Molecular Chaperones; Molecular Sequence Data; Peptide Mapping; Protein Binding; Protein Stability; Protein Structure, Quaternary; Scattering, Radiation; Signal Recognition Particle; Surface Properties; Thiazoles | 2013 |
Inhibition of human islet amyloid polypeptide or amylin aggregation by two manganese-salen derivatives.
Topics: Amyloid; Anilino Naphthalenesulfonates; Antioxidants; Benzothiazoles; Cell Line, Tumor; Cell Survival; Diabetes Mellitus, Type 2; Ethylenediamines; Fluorescent Dyes; Humans; Islet Amyloid Polypeptide; Microscopy, Electron, Transmission; Molecular Docking Simulation; Neuroblastoma; Organometallic Compounds; Salicylates; Thiazoles | 2013 |
Detection and analysis of amorphous aggregates and fibrils of cytochrome c in the presence of phenolic acids.
Topics: Animals; Antioxidants; Benzothiazoles; Coumaric Acids; Cytochromes c; Fluorescent Dyes; Gallic Acid; Horses; Microscopy, Fluorescence; Multiprotein Complexes; Protein Multimerization; Protein Stability; Protein Structure, Quaternary; Protein Structure, Secondary; Proteostasis Deficiencies; Single-Cell Analysis; Thiazoles; Tryptophan | 2013 |
Amyloid fibrils composed of hexameric peptides attenuate neuroinflammation.
Topics: Amino Acid Sequence; Amyloid; Animals; Benzothiazoles; Biotinylation; Blood Proteins; Chemical Precipitation; Encephalomyelitis, Autoimmune, Experimental; Female; Humans; Hydrogen-Ion Concentration; Inflammation; Interleukin-6; Mice; Mice, Inbred C57BL; Molecular Chaperones; Molecular Sequence Data; Nervous System; Paralysis; Peptides; Protein Multimerization; Thiazoles | 2013 |
The response of cerebral cortex to haemorrhagic damage: experimental evidence from a penetrating injury model.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Astrocytes; Benzothiazoles; Brain; Brain Injuries; Cell Death; Cerebral Cortex; Congo Red; Disease Models, Animal; Female; Ferrocyanides; Heme; Hemorrhage; Hippocampus; Humans; Immunohistochemistry; Male; Neocortex; Neurons; Phosphorylation; Rats; Rats, Sprague-Dawley; tau Proteins; Temporal Lobe; Thiazoles; Wounds, Penetrating | 2013 |
Characterization of a single-chain variable fragment recognizing a linear epitope of aβ: a biotechnical tool for studies on Alzheimer's disease?
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Enzyme-Linked Immunosorbent Assay; Epitopes; Humans; Immunoglobulin G; Immunohistochemistry; Ligands; Mice; Mice, Transgenic; Models, Molecular; Molecular Sequence Data; Neurodegenerative Diseases; Permeability; Plasmids; Protein Binding; Sequence Alignment; Single-Chain Antibodies; Thiazoles | 2013 |
Altered protein conformation and lower stability of the dystrophic transforming growth factor beta-induced protein mutants.
Topics: Anilino Naphthalenesulfonates; Benzothiazoles; Circular Dichroism; Corneal Dystrophies, Hereditary; Extracellular Matrix Proteins; Humans; Mutant Proteins; Protein Conformation; Protein Stability; Proteolysis; Recombinant Proteins; Spectrometry, Fluorescence; Thiazoles; Transforming Growth Factor beta; Tryptophan | 2013 |
A label-free, quantitative assay of amyloid fibril growth based on intrinsic fluorescence.
Topics: Amyloid beta-Peptides; Benzothiazoles; Fluorescence; Humans; Kinetics; Particle Size; Peptide Fragments; Thiazoles | 2013 |
A blood-brain barrier (BBB) disrupter is also a potent α-synuclein (α-syn) aggregation inhibitor: a novel dual mechanism of mannitol for the treatment of Parkinson disease (PD).
Topics: alpha-Synuclein; Amyloid; Animals; Antiparkinson Agents; Benzothiazoles; Blood-Brain Barrier; Drosophila; Female; Fluorescent Dyes; Hippocampus; HSP70 Heat-Shock Proteins; Humans; Locomotion; Male; Mannitol; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Microscopy, Electron, Transmission; Neocortex; Parkinson Disease; Protein Multimerization; Protein Structure, Secondary; Thiazoles | 2013 |
N-terminal truncation of an isolated human IgG1 CH2 domain significantly increases its stability and aggregation resistance.
Topics: Benzothiazoles; Drug Stability; Flow Cytometry; Humans; Immunoglobulin G; Protein Binding; Protein Structure, Tertiary; Serum Albumin; Thiazoles | 2013 |
Monitoring the interaction between β2-microglobulin and the molecular chaperone αB-crystallin by NMR and mass spectrometry: αB-crystallin dissociates β2-microglobulin oligomers.
Topics: alpha-Crystallin B Chain; Amyloid; Benzothiazoles; beta 2-Microglobulin; Fluorescent Dyes; Humans; Kinetics; Magnetic Resonance Spectroscopy; Mass Spectrometry; Protein Binding; Protein Interaction Domains and Motifs; Protein Interaction Mapping; Protein Multimerization; Protein Stability; Spectrometry, Mass, Electrospray Ionization; Thiazoles | 2013 |
Methylated BSA mimics amyloid-related proteins and triggers inflammation.
Topics: Amyloid; Amyloidogenic Proteins; Animals; Benzothiazoles; Carrier Proteins; Cells, Cultured; Cytokines; Female; Fluorescent Dyes; Inflammasomes; Inflammation Mediators; Macrophages; Male; Mice; Mice, Inbred BALB C; NLR Family, Pyrin Domain-Containing 3 Protein; Protein Binding; Protein Folding; Serum Albumin, Bovine; Serum Amyloid P-Component; Signal Transduction; Thiazoles | 2013 |
Insights on the binding of Thioflavin derivative markers to amyloid-like fibril models from quantum chemical calculations.
Topics: Amyloid beta-Peptides; Benzothiazoles; Hydrogen Bonding; Ligands; Protein Binding; Protein Structure, Secondary; Quantum Theory; Thiazoles | 2013 |
A radish seed antifungal peptide with a high amyloid fibril-forming propensity.
Topics: Amyloid; Antifungal Agents; Benzothiazoles; Circular Dichroism; Defensins; Fusarium; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Nicotiana; Peptide Fragments; Protein Structure, Secondary; Raphanus; Seeds; Thiazoles; X-Ray Diffraction | 2013 |
Tranilast binds to aβ monomers and promotes aβ fibrillation.
Topics: Amyloid; Amyloid beta-Peptides; Anti-Allergic Agents; Antineoplastic Agents; Benzothiazoles; Binding Sites; Fluorescent Dyes; Humans; Microscopy, Atomic Force; Molecular Docking Simulation; Nuclear Magnetic Resonance, Biomolecular; ortho-Aminobenzoates; Peptide Fragments; Protein Binding; Protein Multimerization; Protein Structure, Quaternary; Thiazoles | 2013 |
Thioflavin-T excimer formation upon interaction with amyloid fibers.
Topics: Amyloid; Amyloid beta-Peptides; Benzothiazoles; Dimerization; Hydrogen-Ion Concentration; Peptide Fragments; Prions; Solvents; Thiazoles | 2013 |
Peptide p5 binds both heparinase-sensitive glycosaminoglycans and fibrils in patient-derived AL amyloid extracts.
Topics: Alcian Blue; Amyloid; Amyloidosis; Benzothiazoles; Carbohydrates; Glycosaminoglycans; Heparin; Heparin Lyase; Humans; Peptides; Protein Binding; Static Electricity; Thiazoles | 2013 |
Molecular characterization of the hetero-assembly of β-amyloid peptide with islet amyloid polypeptide.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Amyloidosis; Animals; Benzothiazoles; Cell Survival; Circular Dichroism; Diabetes Mellitus, Type 2; Islet Amyloid Polypeptide; Kinetics; Microscopy, Electron, Transmission; Molecular Sequence Data; PC12 Cells; Peptide Fragments; Protein Binding; Protein Folding; Protein Multimerization; Rats; Spectrometry, Fluorescence; Thiazoles | 2014 |
The protective effect of crocin on the amyloid fibril formation of Aβ42 peptide in vitro.
Topics: Amyloid; Amyloid beta-Peptides; Anilino Naphthalenesulfonates; Benzothiazoles; Carotenoids; Circular Dichroism; Fluorescent Dyes; Humans; Hydrophobic and Hydrophilic Interactions; Microscopy, Electron; Microscopy, Electron, Transmission; Peptide Fragments; Protein Binding; Thiazoles | 2013 |
Detection and quantification of endoplasmic reticulum stress in living cells using the fluorescent compound, Thioflavin T.
Topics: Animals; Benzothiazoles; Cells, Cultured; Embryo, Mammalian; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Fibroblasts; Fluorescent Dyes; Hep G2 Cells; Humans; Immunoblotting; Liver; Mice; Mice, Knockout; Protein Folding; Protein Multimerization; Thiazoles; Unfolded Protein Response | 2013 |
Stable label-free fluorescent sensing of biothiols based on ThT direct inducing conformation-specific G-quadruplex.
Topics: Benzothiazoles; Biosensing Techniques; Cysteine; Fluorescent Dyes; G-Quadruplexes; Glutathione; Humans; Limit of Detection; Spectrometry, Fluorescence; Thiazoles | 2013 |
Introducing a rigid loop structure from deer into mouse prion protein increases its propensity for misfolding in vitro.
Topics: Amino Acid Substitution; Animals; Benzothiazoles; Cell-Free System; Deer; Endopeptidase K; Lipids; Mice; Prions; Protein Folding; Protein Multimerization; Protein Structure, Secondary; Proteolysis; Thiazoles; Wasting Disease, Chronic | 2013 |
Conditional inactivation of nicastrin restricts amyloid deposition in an Alzheimer's disease mouse model.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Benzothiazoles; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Disease Models, Animal; Gliosis; Humans; Integrases; Membrane Glycoproteins; Mice; Mice, Transgenic; Nerve Degeneration; Neurons; Phenotype; Presenilin-1; Thiazoles | 2013 |
High fluorescence of thioflavin T confined in mesoporous silica xerogels.
Topics: Benzothiazoles; Fluorescence; Gels; Molecular Structure; Particle Size; Porosity; Silicon Dioxide; Spectrometry, Fluorescence; Surface Properties; Thiazoles | 2013 |
Wildtype and A30P mutant alpha-synuclein form different fibril structures.
Topics: alpha-Synuclein; Benzothiazoles; Escherichia coli; Fluorescent Dyes; Humans; Kinetics; Microscopy, Electron, Transmission; Mutation; Protein Multimerization; Protein Structure, Secondary; Recombinant Proteins; Scattering, Small Angle; Solutions; Spectrometry, Fluorescence; Thiazoles; X-Ray Diffraction | 2013 |
Fibrillation of human serum albumin shows nonspecific coordination on stoichiometric increment of Copper(II).
Topics: Benzothiazoles; Congo Red; Coordination Complexes; Copper; Humans; Kinetics; Oxidation-Reduction; Protein Aggregates; Protein Binding; Serum Albumin; Thiazoles | 2014 |
Serial measurement of hFABP and high-sensitivity troponin I post-PCI in STEMI: how fast and accurate can myocardial infarct size and no-reflow be predicted?
Topics: Animals; Benzothiazoles; Biomarkers; Coronary Circulation; Disease Models, Animal; Fatty Acid-Binding Proteins; Female; Hemodynamics; Male; Myocardial Infarction; Myocardial Reperfusion; Myocardium; Necrosis; No-Reflow Phenomenon; Predictive Value of Tests; Risk Factors; Staining and Labeling; Swine; Tetrazolium Salts; Thiazoles; Time Factors; Troponin I; Up-Regulation | 2013 |
Inducing alignment of cyclic peptide nanotubes through the use of structured ionic liquids.
Topics: Benzothiazoles; Borates; Imidazoles; Ionic Liquids; Membranes, Artificial; Nanotubes, Peptide; Temperature; Thiazoles | 2013 |
Selective recognition of ds-DNA cavities by a molecular rotor: switched fluorescence of thioflavin T.
Topics: Benzothiazoles; Biosensing Techniques; DNA; Fluorescent Dyes; Hydrogen-Ion Concentration; Nucleic Acid Denaturation; Spectrometry, Fluorescence; Thiazoles; Transition Temperature | 2013 |
Multiple and cooperative binding of fluorescence light-up probe thioflavin T with human telomere DNA G-quadruplex.
Topics: Algorithms; Benzothiazoles; Binding Sites; Circular Dichroism; DNA; Fluorescent Dyes; G-Quadruplexes; Humans; Kinetics; Models, Molecular; Molecular Structure; Spectrometry, Mass, Electrospray Ionization; Telomere; Thiazoles | 2013 |
Charged surfactants induce a non-fibrillar aggregation pathway of amyloid-beta peptide.
Topics: Amyloid; Amyloid beta-Peptides; Benzothiazoles; Cetrimonium; Cetrimonium Compounds; Fluorescent Dyes; Fourier Analysis; Glucosides; Humans; Kinetics; Micelles; Peptide Fragments; Protein Binding; Protein Multimerization; Protein Structure, Quaternary; Protein Structure, Secondary; Sodium Dodecyl Sulfate; Surface-Active Agents; Thiazoles | 2013 |
Macromolecular crowding as a suppressor of human IAPP fibril formation and cytotoxicity.
Topics: Animals; Benzothiazoles; Cattle; Cell Line; Humans; Islet Amyloid Polypeptide; Microscopy, Atomic Force; Microscopy, Fluorescence; Spectrometry, Fluorescence; Thiazoles | 2013 |
Torsional dynamics of thioflavin T in room-temperature ionic liquids: an effect of heterogeneity of the medium.
Topics: Benzothiazoles; Fluorescent Dyes; Imides; Ionic Liquids; Pyrrolidines; Quaternary Ammonium Compounds; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Temperature; Thiazoles; Viscosity | 2013 |
Neurotoxicity of prion peptides mimicking the central domain of the cellular prion protein.
Topics: Amino Acid Sequence; Animals; Apoptosis; Benzothiazoles; Caspase 3; Cell Membrane Permeability; Cells, Cultured; Dimyristoylphosphatidylcholine; Enzyme Activation; Fluorescent Dyes; Kinetics; Lipid Bilayers; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Molecular Mimicry; Molecular Sequence Data; Neurons; Peptide Fragments; Primary Cell Culture; Protein Multimerization; Protein Structure, Tertiary; PrPC Proteins; Thiazoles | 2013 |
Fructose restrains fibrillogenesis in human serum albumin.
Topics: Benzothiazoles; Circular Dichroism; Fructose; Humans; Hydrogen Bonding; Macromolecular Substances; Models, Molecular; Protein Binding; Protein Conformation; Protein Folding; Serum Albumin; Thermodynamics; Thiazoles | 2013 |
Modulation of Aβ(1-40) peptide fibrillar architectures by Aβ-based peptide amphiphiles.
Topics: Amyloid beta-Peptides; Benzothiazoles; Hydrogen-Ion Concentration; Microscopy, Atomic Force; Peptide Fragments; Protein Binding; Protein Structure, Secondary; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Thermodynamics; Thiazoles | 2013 |
Surface adsorption considerations when working with amyloid fibrils in multiwell plates and Eppendorf tubes.
Topics: Adsorption; Air; Amyloid beta-Peptides; Animals; Benzothiazoles; Caenorhabditis elegans; Cell Extracts; Chromatography, High Pressure Liquid; Kinetics; Mice; Microscopy, Electron; Peptide Fragments; Plastics; Protein Denaturation; Quartz; Thiazoles; Time Factors; Water | 2013 |
Seeded fibrillation as molecular basis of the species barrier in human prion diseases.
Topics: Amyloid; Animals; Benzothiazoles; Cattle; Circular Dichroism; Deer; Humans; Kinetics; Prion Diseases; PrPSc Proteins; Sheep; Species Specificity; Thiazoles; Ultracentrifugation | 2013 |
Molten globule of hemoglobin proceeds into aggregates and advanced glycated end products.
Topics: Animals; Benzothiazoles; Cattle; Circular Dichroism; Congo Red; Glycation End Products, Advanced; Glycosylation; Glyoxal; Hemoglobins; Microscopy, Electron, Scanning; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Thiazoles; Time Factors; Tryptophan | 2013 |
Molecular recognition controlled delivery of a small molecule from a nanocarrier to natural DNA.
Topics: Benzothiazoles; Circular Dichroism; Cyclodextrins; DNA; Drug Carriers; Hydrophobic and Hydrophilic Interactions; Micelles; Nanostructures; Sodium Dodecyl Sulfate; Surface-Active Agents; Thiazoles | 2013 |
The effect of Cu(2+) and Zn(2+) on the Aβ42 peptide aggregation and cellular toxicity.
Topics: Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Line, Tumor; Cell Survival; Copper; Fluorescence; Mice; Protein Binding; Thiazoles; Zinc | 2013 |
Orthogonal high-throughput thermal scanning method for rank ordering protein formulations.
Topics: Algorithms; Antibodies, Monoclonal; Benzothiazoles; Buffers; Chemistry, Pharmaceutical; Chymotrypsinogen; High-Throughput Screening Assays; Peptides; Protein Conformation; Protein Structure, Secondary; Proteins; Real-Time Polymerase Chain Reaction; Solubility; Spectrometry, Fluorescence; Temperature; Thiazoles | 2013 |
Use of a small peptide fragment as an inhibitor of insulin fibrillation process: a study by high and low resolution spectroscopy.
Topics: Animals; Benzothiazoles; Binding Sites; Cattle; Chromatography, Gel; Circular Dichroism; Hemolysis; Humans; Insulin; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Particle Size; Peptide Fragments; Protein Binding; Protein Multimerization; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared; Thermodynamics; Thiazoles | 2013 |
Isolation of a novel thioflavin S-derived compound that inhibits BAG-1-mediated protein interactions and targets BRAF inhibitor-resistant cell lines.
Topics: Aniline Compounds; Animals; Antineoplastic Agents; Benzothiazoles; Binding Sites; Butadienes; Cell Line; Cell Proliferation; DNA-Binding Proteins; Fluorescent Dyes; HEK293 Cells; HSC70 Heat-Shock Proteins; Humans; Indoles; MCF-7 Cells; Mice; Molecular Docking Simulation; Neoplasms; NIH 3T3 Cells; Nitriles; Protein Binding; Proto-Oncogene Proteins B-raf; Sulfonamides; Thiazoles; Transcription Factors; Vemurafenib | 2013 |
Amyloid fibril formation by a normally folded protein in the absence of denaturants and agitation.
Topics: Amyloid; Benzothiazoles; Circular Dichroism; Humans; Lipase; Microscopy, Electron, Transmission; Protein Folding; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2013 |
Influence of Au nanoparticles on the aggregation of amyloid-β-(25-35) peptides.
Topics: Amyloid beta-Peptides; Benzothiazoles; Gold; Metal Nanoparticles; Microscopy, Atomic Force; Peptide Fragments; Protein Structure, Secondary; Static Electricity; Thiazoles | 2013 |
Thioflavin-S staining of bacterial inclusion bodies for the fast, simple, and inexpensive screening of amyloid aggregation inhibitors.
Topics: Amyloid beta-Peptides; Benzothiazoles; Escherichia coli; Humans; Inclusion Bodies; Thiazoles; Time Factors | 2014 |
Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice.
Topics: Aging; alpha-Synuclein; Animals; Autophagy; Benzothiazoles; Brain; Carrier Proteins; Gene Expression; Humans; Mice; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Parkinson Disease; Protein Folding; Solubility; Thiazoles; Ubiquitin | 2014 |
Protein disulfide isomerase interacts with tau protein and inhibits its fibrillization.
Topics: Benzothiazoles; Binding Sites; Cell Line, Tumor; Endoplasmic Reticulum; Escherichia coli; Humans; Kinetics; Neurons; Peptide Fragments; Protein Binding; Protein Disulfide-Isomerases; Protein Folding; Protein Interaction Domains and Motifs; Protein Structure, Secondary; Recombinant Proteins; tau Proteins; Thermodynamics; Thiazoles | 2013 |
The effect of limited proteolysis by different proteases on the formation of whey protein fibrils.
Topics: Amyloid; Benzothiazoles; Circular Dichroism; Hydrogen-Ion Concentration; Hydrolysis; Hydrophobic and Hydrophilic Interactions; Kinetics; Microscopy, Electron, Transmission; Milk Proteins; Pepsin A; Peptide Hydrolases; Protein Structure, Secondary; Proteolysis; Temperature; Thiazoles; Trypsin; Whey Proteins | 2013 |
Disulfide scrambling in superoxide dismutase 1 reduces its cytotoxic effect in cultured cells and promotes protein aggregation.
Topics: Acetamides; Apoenzymes; Benzothiazoles; Cell Line, Tumor; Cell Survival; Cysteine; Cytotoxins; Disulfides; Enzyme Stability; Humans; Protein Multimerization; Protein Structure, Quaternary; Sesquiterpenes; Solubility; Superoxide Dismutase; Superoxide Dismutase-1; Thiazoles | 2013 |
Biophysical investigation of the membrane-disrupting mechanism of the antimicrobial and amyloid-like peptide dermaseptin S9.
Topics: Amino Acid Sequence; Amphibian Proteins; Animals; Anions; Antimicrobial Cationic Peptides; Anura; Benzothiazoles; Cations; Fluorescent Dyes; Kinetics; Lipid Bilayers; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Permeability; Phosphatidylcholines; Phosphatidylglycerols; Protein Binding; Protein Structure, Secondary; Solutions; Spectrometry, Fluorescence; Thiazoles; Unilamellar Liposomes | 2013 |
Effects of environmental factors on MSP21-25 aggregation indicate the roles of hydrophobic and electrostatic interactions in the aggregation process.
Topics: Anilino Naphthalenesulfonates; Antigens, Protozoan; Benzothiazoles; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Methylamines; Peptide Fragments; Protein Multimerization; Protozoan Proteins; Sodium Dodecyl Sulfate; Static Electricity; Thiazoles; Urea | 2014 |
Real-time probing of β-amyloid self-assembly and inhibition using fluorescence self-quenching between neighbouring dyes.
Topics: Amyloid beta-Peptides; Benzothiazoles; Binding Sites; Fluorescence; Fluorescent Dyes; Humans; Kinetics; Peptide Fragments; Protein Binding; Thiazoles | 2014 |
Inhibiting and reversing amyloid-β peptide (1-40) fibril formation with gramicidin S and engineered analogues.
Topics: Amyloid beta-Peptides; Benzothiazoles; Gramicidin; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Microscopy, Atomic Force; Microscopy, Electron, Scanning; Peptide Fragments; Protein Binding; Protein Structure, Secondary; Structure-Activity Relationship; Thiazoles | 2013 |
Islet amyloid polypeptide toxicity and membrane interactions.
Topics: Amino Acid Sequence; Amyloid; Animals; Benzothiazoles; Biophysics; Diabetes Mellitus, Type 2; Humans; Islet Amyloid Polypeptide; Membranes, Artificial; Microscopy, Electron, Transmission; Molecular Sequence Data; Oxazines; Rats; Species Specificity; Thiazoles; Xanthenes | 2013 |
Interaction of thioflavin T with amyloid fibrils of apolipoprotein A-I N-terminal fragment: resonance energy transfer study.
Topics: Amyloid; Apolipoprotein A-I; Benzothiazoles; Binding Sites; Energy Transfer; Humans; Protein Binding; Protein Interaction Domains and Motifs; Thiazoles | 2014 |
Covalently attached fatty acyl chains alter the aggregation behavior of an amyloidogenic peptide derived from human β(2)-microglobulin.
Topics: Acylation; Amino Acid Sequence; Amyloid; Benzothiazoles; beta 2-Microglobulin; Circular Dichroism; Fluorescent Dyes; Humans; Hydrophobic and Hydrophilic Interactions; Microscopy, Fluorescence; Myristic Acid; Palmitic Acid; Peptide Fragments; Protein Multimerization; Protein Stability; Protein Structure, Quaternary; Protein Structure, Secondary; Thiazoles | 2013 |
In vitro evidence that an aqueous extract of Centella asiatica modulates α-synuclein aggregation dynamics.
Topics: alpha-Synuclein; Antiparkinson Agents; Benzothiazoles; Centella; Circular Dichroism; Electrophoresis, Polyacrylamide Gel; Fluorescence; Kinetics; Microscopy, Electron, Transmission; Plant Extracts; Polyphenols; Protein Multimerization; Thiazoles; Triterpenes; Water | 2014 |
Membrane-anchored Aβ accelerates amyloid formation and exacerbates amyloid-associated toxicity in mice.
Topics: Amyloid beta-Peptides; Animals; Benzothiazoles; Biotinylation; Blotting, Western; Cell Membrane; Endopeptidase K; Fluorescent Dyes; HEK293 Cells; Humans; Immunohistochemistry; Inflammation; Mice; Mice, Inbred C57BL; Phosphatidylinositols; Plaque, Amyloid; Thiazoles; Type C Phospholipases | 2013 |
Identification of an amyloidogenic peptide from the Bap protein of Staphylococcus epidermidis.
Topics: Amyloidogenic Proteins; Bacterial Proteins; Benzothiazoles; Biofilms; Membrane Proteins; Microscopy, Atomic Force; Spectrophotometry, Infrared; Staphylococcus epidermidis; Thiazoles | 2014 |
Fluorescence Investigation of Interactions Between Novel Benzanthrone Dyes and Lysozyme Amyloid Fibrils.
Topics: Amyloid; Benz(a)Anthracenes; Benzothiazoles; Coloring Agents; Microscopy, Electron, Transmission; Muramidase; Spectrometry, Fluorescence; Thiazoles | 2014 |
pH dependence of amylin fibrillization.
Topics: Animals; Benzothiazoles; Cell Survival; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Insulin-Secreting Cells; Islet Amyloid Polypeptide; Kinetics; Mice; Models, Animal; Models, Molecular; Molecular Structure; Protein Binding; Structure-Activity Relationship; Thiazoles; Tumor Cells, Cultured | 2014 |
Comparison of two methods for the estimation of stability of copper(II) bis-complexes with aromatic ligands relevant to Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Benzothiazoles; Copper; Humans; Ligands; Organometallic Compounds; Plaque, Amyloid; Regression Analysis; Thiazoles | 2013 |
Molecular rotor-based fluorescent probe for selective recognition of hybrid G-quadruplex and as a K+ sensor.
Topics: Benzene; Benzothiazoles; Fluorescent Dyes; G-Quadruplexes; Potassium; Rotation; Spectrometry, Fluorescence; Substrate Specificity; Thiazoles; Transition Temperature | 2014 |
Neuronal inclusions of α-synuclein contribute to the pathogenesis of Krabbe disease.
Topics: alpha-Synuclein; Animals; Benzothiazoles; Brain; Case-Control Studies; Cognition; Disease Models, Animal; Fluorescent Dyes; Humans; Leukodystrophy, Globoid Cell; Lewy Bodies; Mice; Motor Activity; Mutation; Neurons; Psychosine; Thiazoles | 2014 |
Exogenous amyloidogenic proteins function as seeds in amyloid β-protein aggregation.
Topics: Amyloid beta-Peptides; Amyloidogenic Proteins; Amyloidosis; Benzothiazoles; Humans; Magnetic Resonance Spectroscopy; Microscopy, Electron; Thiazoles | 2014 |
[Application of thioflavin T staining in detection of β-amyloid].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Cerebral Amyloid Angiopathy; Fluorescent Dyes; Humans; Mice; Peptide Fragments; Staining and Labeling; Thiazoles | 2013 |
Peptide detection of fungal functional amyloids in infected tissue.
Topics: Amino Acid Sequence; Amyloid; Autopsy; Benzenesulfonates; Benzothiazoles; Candida albicans; Candidiasis; Fluorescent Dyes; Fungal Proteins; Gene Deletion; Humans; Hyphae; Molecular Sequence Data; Organ Specificity; Peptides; Protein Binding; Protein Structure, Quaternary; Saccharomyces cerevisiae; Silver Staining; Staining and Labeling; Thiazoles | 2014 |
Photophysics of flavin derivatives absorbing in the blue-green region: thioflavins as potential cofactors of photoswitches.
Topics: Absorption; Algorithms; Benzothiazoles; Flavin Mononucleotide; Flavins; Gases; Light; Molecular Structure; Solutions; Solvents; Spectrum Analysis; Thiazoles; Water | 2014 |
Synthesis of 2,5-diaryl-substituted thiophenes as helical mimetics: towards the modulation of islet amyloid polypeptide (IAPP) amyloid fibril formation and cytotoxicity.
Topics: Amyloid; Benzothiazoles; Insulin-Secreting Cells; Islet Amyloid Polypeptide; Molecular Structure; Thiazoles; Thiophenes | 2014 |
Live imaging of prions reveals nascent PrPSc in cell-surface, raft-associated amyloid strings and webs.
Topics: Actins; Amyloid; Animals; Antibodies; Benzothiazoles; Cell Survival; Endocytosis; Hippocampus; Imaging, Three-Dimensional; Membrane Microdomains; Mice; Models, Biological; Phosphoinositide Phospholipase C; Polysaccharides; Protein Binding; Protein Denaturation; PrPSc Proteins; Staining and Labeling; Thiazoles | 2014 |
New insight into the binding interaction of hydroxylated carbon nanotubes with bovine serum albumin.
Topics: Animals; Benzothiazoles; Cattle; Circular Dichroism; Guanidine; Hydrogen-Ion Concentration; Hydroxylation; Kinetics; Molecular Docking Simulation; Nanotubes, Carbon; Protein Aggregates; Protein Binding; Protein Denaturation; Protein Structure, Secondary; Serum Albumin, Bovine; Spectrometry, Fluorescence; Thiazoles | 2014 |
Thioflavin T as a fluorescence light-up probe for G4 formation.
Topics: Benzothiazoles; Fluorescent Dyes; G-Quadruplexes; Native Polyacrylamide Gel Electrophoresis; Thiazoles | 2014 |
Inhibition study on insulin fibrillation and cytotoxicity by paclitaxel.
Topics: Amyloid; Animals; Benzothiazoles; Cell Differentiation; Circular Dichroism; Dose-Response Relationship, Drug; Fluorescence; Hydrogen Bonding; Insulin; Microscopy, Atomic Force; Molecular Dynamics Simulation; Paclitaxel; PC12 Cells; Protein Multimerization; Protein Structure, Secondary; Rats; Thiazoles | 2014 |
Preventing disulfide bond formation weakens non-covalent forces among lysozyme aggregates.
Topics: Amyloid; Animals; Anisotropy; Benzothiazoles; Crystallization; Disulfides; Hydrophobic and Hydrophilic Interactions; Microscopy, Atomic Force; Muramidase; Physical Phenomena; Protein Structure, Quaternary; Spectrometry, Fluorescence; Thiazoles | 2014 |
Self-assembling properties of peptides derived from TDP-43 C-terminal fragment.
Topics: Amino Acid Sequence; Benzothiazoles; DNA-Binding Proteins; Humans; Hydrogels; Hydrophobic and Hydrophilic Interactions; Molecular Sequence Data; Protein Aggregates; Protein Folding; Protein Structure, Tertiary; Spectrometry, Fluorescence; Structure-Activity Relationship; Thiazoles | 2014 |
Amyloid peptides derived from CsgA and FapC modify the viscoelastic properties of biofilm model matrices.
Topics: Amino Acid Sequence; Amyloid; Bacterial Proteins; Benzothiazoles; Biofilms; Elasticity; Escherichia coli Proteins; Molecular Sequence Data; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared; Stress, Mechanical; Thiazoles; Viscosity | 2014 |
Label-free fluorescent biosensor based on the target recycling and Thioflavin T-induced quadruplex formation for short DNA species of c-erbB-2 detection.
Topics: Base Pair Mismatch; Benzothiazoles; Biosensing Techniques; Breast Neoplasms; DNA; Female; Fluorescent Dyes; G-Quadruplexes; Humans; Nucleic Acid Amplification Techniques; Receptor, ErbB-2; Saliva; Thiazoles | 2014 |
Protonation favors aggregation of lysozyme with SDS.
Topics: Animals; Benzothiazoles; Chickens; Congo Red; Hydrogen-Ion Concentration; Kinetics; Muramidase; Protein Binding; Protein Structure, Secondary; Protons; Sodium Dodecyl Sulfate; Static Electricity; Thiazoles | 2014 |
Effect of temperature and solvent on fibrillation of human serum albumin.
Topics: Benzothiazoles; Circular Dichroism; Ethanol; Fluorescence Polarization; Humans; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Protein Conformation; Protein Multimerization; Serum Albumin; Temperature; Thermodynamics; Thiazoles; Water | 2015 |
Complexation of amyloid fibrils with charged conjugated polymers.
Topics: alpha-Synuclein; Amino Acid Sequence; Amyloid; Benzothiazoles; Escherichia coli; Fluorocarbon Polymers; Gene Expression; Humans; Kinetics; Microscopy, Atomic Force; Molecular Sequence Data; Protein Aggregates; Recombinant Proteins; Solutions; Spectroscopy, Fourier Transform Infrared; Static Electricity; Thiazoles | 2014 |
Active and peripheral anionic sites of acetylcholinesterase have differential modulation effects on cell proliferation, adhesion and neuritogenesis in the NG108-15 cell line.
Topics: Acetylcholinesterase; Animals; Benzothiazoles; Binding Sites; Cell Adhesion; Cell Line; Cell Proliferation; Humans; Mice; Neurites; Paraoxon; Rats; Thiazoles | 2014 |
CH-π interaction in VQIVYK sequence elucidated by NMR spectroscopy is essential for PHF formation of tau.
Topics: Amino Acid Motifs; Amino Acid Sequence; Benzothiazoles; Fluorescence; Molecular Sequence Data; Mutant Proteins; Nuclear Magnetic Resonance, Biomolecular; Peptides; Protein Stability; Protein Structure, Secondary; Protein Structure, Tertiary; tau Proteins; Thiazoles; Time Factors | 2014 |
Rationally designed peptoids modulate aggregation of amyloid-beta 40.
Topics: Amyloid beta-Peptides; Benzothiazoles; Binding, Competitive; Circular Dichroism; Fluorescence; Immunoblotting; Peptide Fragments; Peptoids; Protein Structure, Secondary; Thiazoles; Time Factors | 2014 |
Addition of αA-crystallin sequence 164-173 to a mini-chaperone DFVIFLDVKHFSPEDLT alters the conformation but not the chaperone-like activity.
Topics: alpha-Crystallin A Chain; Amino Acid Sequence; Animals; Benzothiazoles; Chlorocebus aethiops; Circular Dichroism; COS Cells; Hydrogen Peroxide; Microscopy, Electron, Transmission; Molecular Chaperones; Molecular Sequence Data; Peptide Fragments; Protein Conformation; Protein Engineering; Recombinant Proteins; Thiazoles | 2014 |
Mutational analysis of preamyloid intermediates: the role of his-tyr interactions in islet amyloid formation.
Topics: Amino Acid Sequence; Amyloid; Benzothiazoles; DNA Mutational Analysis; Genetic Variation; Histidine; Humans; Hydrogen-Ion Concentration; Islet Amyloid Polypeptide; Microscopy, Electron, Transmission; Molecular Sequence Data; Mutation; Protein Structure, Tertiary; Spectrum Analysis; Thiazoles; Tyrosine | 2014 |
A highly sensitive label-free sensor for Mercury ion (Hg²⁺) by inhibiting thioflavin T as DNA G-quadruplexes fluorescent inducer.
Topics: Benzothiazoles; Biosensing Techniques; Fluorescent Dyes; G-Quadruplexes; Mercury; Spectrometry, Fluorescence; Thiazoles; Water Pollutants, Chemical | 2014 |
Quantitative analysis of the flavonoid glycosides and terpene trilactones in the extract of Ginkgo biloba and evaluation of their inhibitory activity towards fibril formation of β-amyloid peptide.
Topics: Amyloid beta-Peptides; Benzothiazoles; Flavonoids; Ginkgo biloba; Glycosides; Humans; Lactones; Peptide Fragments; Plant Extracts; Plant Leaves; Spectrometry, Fluorescence; Structure-Activity Relationship; Terpenes; Thiazoles | 2014 |
Deciphering aggregates, prefibrillar oligomers and protofibrils of cytochrome c.
Topics: Anilino Naphthalenesulfonates; Benzothiazoles; Circular Dichroism; Cytochromes c; DNA Damage; Humans; Microscopy, Electron, Scanning; Neurodegenerative Diseases; Polyethylene Glycols; Protein Aggregates; Protein Conformation; Protein Folding; Proteostasis Deficiencies; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Surface-Active Agents; Thiazoles; Trifluoroethanol | 2014 |
Secondary structure changes in ApoA-I Milano (R173C) are not accompanied by a decrease in protein stability or solubility.
Topics: Amyloid; Animals; Apolipoprotein A-I; Benzothiazoles; Humans; Male; Mice, Inbred C57BL; Mutation, Missense; Protein Aggregates; Protein Binding; Protein Stability; Protein Structure, Secondary; Solubility; Thiazoles | 2014 |
Gallic acid interacts with α-synuclein to prevent the structural collapse necessary for its aggregation.
Topics: alpha-Synuclein; Amyloid; Benzothiazoles; Flocculation; Fluorescent Dyes; Gallic Acid; Humans; Magnetic Resonance Spectroscopy; Microscopy, Electron, Transmission; Protein Binding; Recombinant Proteins; Spectrometry, Fluorescence; Thiazoles | 2014 |
Randomly arrayed G-quadruplexes for label-free and real-time assay of enzyme activity.
Topics: Benzothiazoles; Biological Assay; Biosensing Techniques; DNA Nucleotidylexotransferase; DNA, Catalytic; G-Quadruplexes; Hemin; Peroxidase; Spectrometry, Fluorescence; Thiazoles | 2014 |
Pitfalls associated with the use of Thioflavin-T to monitor anti-fibrillogenic activity.
Topics: alpha-Synuclein; Amyloid; Artifacts; Benzothiazoles; Humans; Protein Structure, Tertiary; Structure-Activity Relationship; Thiazoles | 2014 |
Effects of ferrofluid and phytoalexin spirobrassinin on thioflavin-T-based fluorescence in cerebrospinal fluid of the elderly and multiple sclerosis patients.
Topics: Adult; Aged; Aging; Benzothiazoles; Chlorides; Female; Ferric Compounds; Ferrous Compounds; Fluorescence; Fluorescent Dyes; Humans; Male; Middle Aged; Multiple Sclerosis; Spiro Compounds; Thiazoles | 2014 |
'Clickable' 2,5-diketopiperazines as scaffolds for ligation of biomolecules: their use in Aβ inhibitor assembly.
Topics: Amyloid beta-Peptides; Benzothiazoles; Curcumin; Diketopiperazines; Ligation; Thiazoles | 2014 |
Crowded milieu prevents fibrillation of hen egg white lysozyme with retention of enzymatic activity.
Topics: Animals; Benzothiazoles; Chickens; Enzyme Activation; Hydrodynamics; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Muramidase; Polyethylene Glycols; Protein Binding; Protein Structure, Secondary; Thiazoles | 2014 |
Gain in toxic function of stefin B EPM1 mutants aggregates: correlation between cell death, aggregate number/size and oxidative stress.
Topics: Amyloid; Animals; Annexin A5; Benzothiazoles; Cell Count; Cell Death; Cell Survival; CHO Cells; Cricetinae; Cricetulus; Cystatin B; HEK293 Cells; Humans; Kinetics; Mutant Proteins; Oxidative Stress; Propidium; Protein Structure, Quaternary; Spectrometry, Fluorescence; Thiazoles; Transfection; Unverricht-Lundborg Syndrome | 2014 |
Inhibition of tau aggregation by a rosamine derivative that blocks tau intermolecular disulfide cross-linking.
Topics: Benzothiazoles; Disulfides; Drug Discovery; Escherichia coli; Fluorescent Dyes; Gene Expression; Humans; Oxidation-Reduction; Peptide Fragments; Protein Aggregates; Protein Multimerization; Recombinant Proteins; Small Molecule Libraries; Solutions; Spectrometry, Fluorescence; tau Proteins; Thiazoles; Xanthenes | 2014 |
β-cyclodextrin and curcumin, a potent cocktail for disaggregating and/or inhibiting amyloids: a case study with α-synuclein.
Topics: alpha-Synuclein; Amyloid; Benzothiazoles; beta-Cyclodextrins; Circular Dichroism; Curcumin; Drug Synergism; Fluorescent Dyes; Thiazoles | 2014 |
Amyloids of alpha-synuclein affect the structure and dynamics of supported lipid bilayers.
Topics: Adsorption; alpha-Synuclein; Amyloid; Benzothiazoles; Lipid Bilayers; Liposomes; Mutant Proteins; Phosphatidylcholines; Phosphatidylglycerols; Protein Aggregates; Protein Binding; Staining and Labeling; Thiazoles | 2014 |
Soluble, prefibrillar α-synuclein oligomers promote complex I-dependent, Ca2+-induced mitochondrial dysfunction.
Topics: alpha-Synuclein; Animals; Benzothiazoles; Biopolymers; Calcium; Electron Transport Complex I; Humans; Membrane Potential, Mitochondrial; Mice; Mitochondria; Thiazoles | 2014 |
SEVI, the semen enhancer of HIV infection along with fragments from its central region, form amyloid fibrils that are toxic to neuronal cells.
Topics: Acid Phosphatase; Amino Acid Motifs; Amyloid; Animals; Benzothiazoles; Caco-2 Cells; Cell Survival; Fluorescent Dyes; HIV-1; Humans; Microscopy, Electron, Transmission; Molecular Sequence Data; Organ Specificity; PC12 Cells; Peptide Fragments; Protein Tyrosine Phosphatases; Rats; Semen; Spectrometry, Fluorescence; Thiazoles; Virus Attachment | 2014 |
epi-Fluorescence imaging at the air-water interface of fibrillization of bovine serum albumin and human insulin.
Topics: Air; Benzothiazoles; Fluorescence; Fluorescent Dyes; Humans; Insulin; Microscopy, Atomic Force; Microscopy, Fluorescence; Serum Albumin, Bovine; Thiazoles; Water | 2014 |
Inhibition of islet amyloid polypeptide fibril formation by selenium-containing phycocyanin and prevention of beta cell apoptosis.
Topics: Animals; Apoptosis; Benzothiazoles; Caspase 3; Cell Membrane; Cell Shape; Enzyme Activation; Fluorescence; Fluorescent Antibody Technique; Humans; In Situ Nick-End Labeling; Indoles; Insulin-Secreting Cells; Islet Amyloid Polypeptide; Membrane Potential, Mitochondrial; Phycocyanin; Poly(ADP-ribose) Polymerases; Protective Agents; Rats; Reactive Oxygen Species; Selenium; Thiazoles | 2014 |
Electrochemical detection of the oligomerization of PB1-F2 influenza A virus protein in infected cells.
Topics: Antibodies, Monoclonal; Benzothiazoles; Biosensing Techniques; Cell Line, Tumor; Electrochemical Techniques; Humans; Influenza A virus; Microscopy, Atomic Force; Protein Multimerization; Recombinant Proteins; Thiazoles; Viral Proteins | 2014 |
Amyloid transition of ubiquitin on silver nanoparticles produced by pulsed laser ablation in liquid as a function of stabilizer and single-point mutations.
Topics: Amyloid; Benzothiazoles; Citrates; Humans; Lasers; Metal Nanoparticles; Point Mutation; Protein Structure, Secondary; Silver; Sodium Citrate; Surface Plasmon Resonance; Thiazoles; Ubiquitin | 2014 |
The influence of pathological mutations and proline substitutions in TDP-43 glycine-rich peptides on its amyloid properties and cellular toxicity.
Topics: Amino Acid Sequence; Amino Acid Substitution; Amyloid; Animals; Benzothiazoles; Cell Membrane; DNA-Binding Proteins; Glycine; Mice; Molecular Sequence Data; Mutant Proteins; Mutation; Peptides; Proline; Protein Aggregates; Protein Multimerization; Protein Structure, Secondary; Spectrum Analysis, Raman; Thiazoles; Time Factors | 2014 |
Selective interception of gelsolin amyloidogenic stretch results in conformationally distinct aggregates with reduced toxicity.
Topics: Amyloid; Benzothiazoles; Curcumin; Emetine; Fluorescence; Gelsolin; Hydrophobic and Hydrophilic Interactions; Kinetics; Light; Microscopy, Atomic Force; Molecular Docking Simulation; Particle Size; Peptides; Scattering, Radiation; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2014 |
Mechanistic aspects of thioflavin-T self-aggregation and DNA binding: evidence for dimer attack on DNA grooves.
Topics: Benzothiazoles; Dimerization; DNA; Kinetics; Molecular Dynamics Simulation; Quantum Theory; Spectrophotometry; Temperature; Thiazoles; Viscosity | 2014 |
Addressing mechanism of fibrillization/aggregation and its prevention in presence of osmolytes: spectroscopic and calorimetric approach.
Topics: Amyloid; Animals; Benzothiazoles; Calorimetry, Differential Scanning; Chickens; Kinetics; Muramidase; Osmolar Concentration; Protein Aggregates; Spectrometry, Fluorescence; Thiazoles; Titrimetry | 2014 |
De novo design of self-assembled hexapeptides as β-amyloid (Aβ) peptide inhibitors.
Topics: Amyloid beta-Peptides; Benzothiazoles; Cell Line, Tumor; Cell Survival; Circular Dichroism; Drug Design; Fluorescence; High-Throughput Screening Assays; Humans; Microscopy, Atomic Force; Molecular Dynamics Simulation; Neuroprotective Agents; Oligopeptides; Protein Multimerization; Surface Plasmon Resonance; Thiazoles | 2014 |
Differential regulation of resolution in inflammation induced by amyloid-β42 and lipopolysaccharides in human microglia.
Topics: Adaptor Proteins, Signal Transducing; alpha7 Nicotinic Acetylcholine Receptor; Amyloid beta-Peptides; Benzothiazoles; Blotting, Western; Cell Line; Extracellular Signal-Regulated MAP Kinases; Humans; Lipopolysaccharides; Lipoxygenases; Microglia; Multivariate Analysis; Peptide Fragments; PPAR delta; Receptors, Formyl Peptide; Receptors, Lipoxin; Thiazoles | 2015 |
Conformational behaviour and aggregation of chickpea cystatin in trifluoroethanol: effects of epicatechin and tannic acid.
Topics: Amyloid; Benzothiazoles; Calibration; Catechin; Cicer; Circular Dichroism; Cystatins; Microscopy, Electron, Transmission; Nephelometry and Turbidimetry; Papain; Protein Binding; Protein Denaturation; Protein Structure, Secondary; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Tannins; Thiazoles; Trifluoroethanol | 2014 |
Spared piriform cortical single-unit odor processing and odor discrimination in the Tg2576 mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Behavior, Animal; Benzothiazoles; Disease Models, Animal; Entorhinal Cortex; Female; Habituation, Psychophysiologic; Hippocampus; Male; Memory; Mice, Transgenic; Odorants; Olfactory Bulb; Olfactory Pathways; Piriform Cortex; Thiazoles | 2014 |
The potential of indole and a synthetic derivative for polyQ aggregation reduction by enhancement of the chaperone and autophagy systems.
Topics: Ataxin-3; Autophagy; Benzothiazoles; Blotting, Western; Caspase 3; Cell Aggregation; Cell Line, Tumor; Fluorescence; Green Fluorescent Proteins; HEK293 Cells; HSP70 Heat-Shock Proteins; Humans; Immunohistochemistry; Indoles; Molecular Chaperones; Nerve Tissue Proteins; Neurites; Neurons; Neuroprotective Agents; Nuclear Proteins; Peptides; Reactive Oxygen Species; Repressor Proteins; Spinocerebellar Ataxias; Thiazoles | 2014 |
Different effect of vitamin D2 and vitamin D3 on amyloid-β40 aggregation in vitro.
Topics: Amyloid beta-Peptides; Benzothiazoles; Cholecalciferol; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Ergocalciferols; Humans; In Vitro Techniques; Microscopy, Electron; Models, Chemical; Molecular Docking Simulation; Peptide Fragments; Plaque, Amyloid; Protein Interaction Mapping; Quartz Crystal Microbalance Techniques; Thiazoles; Time Factors | 2014 |
Influence of pH control in the formation of inclusion bodies during production of recombinant sphingomyelinase-D in Escherichia coli.
Topics: Animals; Benzothiazoles; Biomass; Congo Red; Endopeptidase K; Escherichia coli; Guanidine; Hydrogen-Ion Concentration; Inclusion Bodies; Kinetics; Phosphoric Diester Hydrolases; Recombinant Proteins; Solubility; Spectrometry, Fluorescence; Thiazoles; Ticks | 2014 |
Selective recognition of parallel and anti-parallel thrombin-binding aptamer G-quadruplexes by different fluorescent dyes.
Topics: Aptamers, Nucleotide; Benzothiazoles; Fluorescent Dyes; G-Quadruplexes; Mesoporphyrins; Molecular Docking Simulation; Thiazoles | 2014 |
Ultrafast twisting dynamics of thioflavin-T: spectroscopy of the twisted intramolecular charge-transfer state.
Topics: Benzothiazoles; Fluorescent Dyes; Models, Molecular; Quantum Theory; Spectrometry, Fluorescence; Thiazoles; Time Factors | 2014 |
The Alzheimer disease protective mutation A2T modulates kinetic and thermodynamic properties of amyloid-β (Aβ) aggregation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Benzothiazoles; Brain; Cell Culture Techniques; Cell Line; Cricetinae; Disease Models, Animal; Humans; Kinetics; Mice; Mice, Inbred C57BL; Mutagenesis; Mutation; Neurons; Peptide Fragments; Solubility; Thermodynamics; Thiazoles | 2014 |
Stability and cytotoxicity of crystallin amyloid nanofibrils.
Topics: Amyloid; Animals; Benzothiazoles; Cell Line; Cell Survival; Crystallins; Endometrial Neoplasms; Female; Fishes; Humans; Hydrogen-Ion Concentration; Insulin; Lens, Crystalline; Microscopy, Electron, Transmission; Nanofibers; Nanoparticles; Peptide Hydrolases; Solvents; Spectrophotometry, Infrared; Spectroscopy, Fourier Transform Infrared; Temperature; Thiazoles; Whey Proteins | 2014 |
Detection of Aβ-interacting proteins via a novel Aβ-adsorbents that use immobilized regular comb polymer.
Topics: Adsorption; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain Chemistry; Fluorescent Dyes; Immobilized Proteins; Mice; Nerve Tissue Proteins; Polymers; Sepharose; Thiazoles | 2014 |
Design of non-aggregating variants of Aβ peptide.
Topics: Amyloid beta-Peptides; Animals; Benzothiazoles; Microscopy, Electron, Scanning; Mutation; PC12 Cells; Peptides; Rats; Thiazoles | 2014 |
Resonance Raman spectroscopic measurements delineate the structural changes that occur during tau fibril formation.
Topics: Amyloid; Benzothiazoles; Fluorescent Dyes; Heparin; Humans; Intrinsically Disordered Proteins; Kinetics; Microscopy, Atomic Force; Models, Molecular; Protein Aggregation, Pathological; Protein Conformation; Protein Interaction Domains and Motifs; Protein Stability; Protein Structure, Secondary; Recombinant Proteins; Repetitive Sequences, Amino Acid; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Spectrum Analysis, Raman; tau Proteins; Thiazoles | 2014 |
Imaging and quantification of amyloid fibrillation in the cell nucleus.
Topics: Amyloid; Animals; Benzothiazoles; Caenorhabditis elegans; Cell Culture Techniques; Cell Line, Tumor; Cell Nucleus; Congo Red; Humans; Microscopy, Fluorescence; Molecular Imaging; Nanoparticles; Protein Multimerization; Protein Structure, Secondary; Silicon Dioxide; Staining and Labeling; Thiazoles; Tissue Fixation | 2015 |
Thioflavin-based molecular probes for application in Alzheimer's disease: from in silico to in vitro models.
Topics: Alzheimer Disease; Animals; Benzothiazoles; Brain; Brain Chemistry; Cell Line; Cell Survival; Humans; Mice; Models, Biological; Molecular Docking Simulation; Molecular Probes; Phenols; Thiazoles | 2015 |
pH-dependent differential interacting mechanisms of sodium dodecyl sulfate with bovine serum fetuin: a biophysical insight.
Topics: Animals; Benzothiazoles; Calorimetry; Cattle; Circular Dichroism; Fetuins; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Microscopy, Electron, Transmission; Nephelometry and Turbidimetry; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Sodium Dodecyl Sulfate; Spectrometry, Fluorescence; Static Electricity; Thermodynamics; Thiazoles; Tryptophan | 2014 |
Exploiting the therapeutic potential of 8-β-d-glucopyranosylgenistein: synthesis, antidiabetic activity, and molecular interaction with islet amyloid polypeptide and amyloid β-peptide (1-42).
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Diabetes Mellitus, Experimental; Drug Design; Epitopes; Genista; Genistein; Glucosides; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin; Islet Amyloid Polypeptide; Magnetic Resonance Spectroscopy; Microscopy, Atomic Force; Microscopy, Fluorescence; Oxygen; Protein Binding; Protein Conformation; Protein Kinase Inhibitors; Rats; Rats, Wistar; Streptozocin; Thiazoles | 2014 |
Probing structural changes of self assembled i-motif DNA.
Topics: Benzothiazoles; Biosensing Techniques; Circular Dichroism; Fluorescent Dyes; Hydrogen-Ion Concentration; Nucleotide Motifs; Proto-Oncogene Proteins c-ret; Retinoblastoma Protein; Spectrometry, Fluorescence; Thiazoles | 2015 |
Early sodium dodecyl sulfate induced collapse of α-synuclein correlates with its amyloid formation.
Topics: alpha-Synuclein; Amyloid; Benzothiazoles; Circular Dichroism; Entropy; Escherichia coli; Fluorescence Resonance Energy Transfer; Glycerol; Microscopy, Electron, Transmission; Mutation; Protein Structure, Secondary; Recombinant Proteins; Sodium Dodecyl Sulfate; Solutions; Solvents; Spectrometry, Fluorescence; Thiazoles; Urea | 2015 |
Ultrafast propagation of β-amyloid fibrils in oligomeric cloud.
Topics: Amyloid beta-Peptides; Benzothiazoles; Flocculation; Fluorescent Dyes; Humans; Microscopy, Fluorescence; Peptide Fragments; Protein Aggregates; Protein Multimerization; Protein Structure, Secondary; Quartz Crystal Microbalance Techniques; Solutions; Thiazoles | 2014 |
The aggregation of aβ42 induced by nano copper and the antagonistic action of polysaccharides.
Topics: Amyloid beta-Peptides; Benzothiazoles; Circular Dichroism; Copper; Fluorescence; Kinetics; Microscopy, Atomic Force; Nanoparticles; Peptide Fragments; Polysaccharides; Protein Aggregates; Protein Structure, Secondary; Thiazoles; X-Ray Diffraction | 2015 |
Minimal thioflavin T modifications improve visual discrimination of guanine-quadruplex topologies and alter compound-induced topological structures.
Topics: Benzothiazoles; DNA; G-Quadruplexes; Nucleic Acid Conformation; Spectrometry, Fluorescence; Thiazoles | 2014 |
Apparent circular dichroism signature of stirring-oriented DNA and drug-DNA complexes.
Topics: Animals; Benzamides; Benzothiazoles; Binding Sites; Cattle; Circular Dichroism; DNA; Humans; Imatinib Mesylate; Nucleic Acid Conformation; Piperazines; Protein Structure, Tertiary; Pyrimidines; Spectrophotometry, Ultraviolet; Thiazoles; Water | 2015 |
Targeting BAG-1: a novel strategy to increase drug efficacy in acute myeloid leukemia.
Topics: Antineoplastic Agents; Benzothiazoles; Child; Child, Preschool; DNA-Binding Proteins; Drug Delivery Systems; Drug Therapy, Combination; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Infant; Leukemia, Myeloid, Acute; Thiazoles; Transcription Factors | 2015 |
Enzyme-free and label-free fluorescence sensor for the detection of liver cancer related short gene.
Topics: Base Sequence; Benzothiazoles; DNA; G-Quadruplexes; Glypicans; Humans; Limit of Detection; Liver Neoplasms; Spectrometry, Fluorescence; Thiazoles | 2015 |
Increased acetyl and total histone levels in post-mortem Alzheimer's disease brain.
Topics: Aged; Alzheimer Disease; Amyloid; Benzothiazoles; Blotting, Western; Brain; Cell Line, Tumor; Female; Fluorescent Antibody Technique; Histones; Humans; Male; Neurofibrillary Tangles; Plaque, Amyloid; tau Proteins; Thiazoles; Tissue Array Analysis; Ubiquitin | 2015 |
The impact of calcium ion on structure and aggregation propensity of peroxynitrite-modified lens crystallins: new insights into the pathogenesis of cataract disorders.
Topics: Animals; Benzothiazoles; Calcium; Cattle; Crystallins; Hydrophobic and Hydrophilic Interactions; Lens, Crystalline; Oxidants; Peroxynitrous Acid; Protein Aggregates; Protein Carbonylation; Protein Stability; Proteolysis; Spectrometry, Fluorescence; Thiazoles; Tryptophan; Tyrosine | 2015 |
Pretreatment of chemically-synthesized Aβ42 affects its biological activity in yeast.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Apoptosis; Benzothiazoles; Candida glabrata; Flow Cytometry; Microscopy, Confocal; Microscopy, Electron, Transmission; Neurons; Peptide Fragments; Peptides; Propanols; Protein Binding; Protein Conformation; Saccharomyces cerevisiae; Thiazoles | 2014 |
[Investigation of the kinetics of insulin amyloid fibrils formation].
Topics: Amyloid; Benzothiazoles; Fluorescent Dyes; Hydrogen-Ion Concentration; Insulin; Kinetics; Protein Aggregates; Solutions; Temperature; Thermodynamics; Thiazoles | 2013 |
K114 (trans, trans)-bromo-2,5-bis(4-hydroxystyryl)benzene is an efficient detector of cationic amyloid fibrils.
Topics: Amino Acid Sequence; Amyloid; Benzothiazoles; Fluorescent Dyes; Humans; Insulin; Molecular Sequence Data; Styrenes; Thiazoles | 2015 |
Mutational analysis of the ability of resveratrol to inhibit amyloid formation by islet amyloid polypeptide: critical evaluation of the importance of aromatic-inhibitor and histidine-inhibitor interactions.
Topics: Amino Acid Sequence; Amino Acids, Aromatic; Amyloid; Arginine; Benzothiazoles; Catechin; DNA Mutational Analysis; Histidine; Humans; Islet Amyloid Polypeptide; Molecular Sequence Data; Mutant Proteins; Resveratrol; Spectrometry, Mass, Electrospray Ionization; Stilbenes; Structure-Activity Relationship; Thiazoles | 2015 |
Amyloid-like conformation and interaction for the self-assembly in barnacle underwater cement.
Topics: Adhesives; Amino Acid Sequence; Amyloid; Animals; Benzothiazoles; Circular Dichroism; Imaging, Three-Dimensional; Microscopy, Atomic Force; Molecular Sequence Data; Peptides; Protein Structure, Secondary; Proteins; Thiazoles; Thoracica; Water | 2015 |
Towards ratiometric sensing of amyloid fibrils in vitro.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Binding Sites; Cattle; Electrochemistry; Fluorescence; Fluorescent Dyes; Humans; Imidazoles; Protein Binding; Pyridines; Serum Albumin, Bovine; Thiazoles | 2015 |
Cyclin-dependent kinase 5 phosphorylation of familial prion protein mutants exacerbates conversion into amyloid structure.
Topics: Amyloid; Benzothiazoles; Blotting, Western; Circular Dichroism; Cyclin-Dependent Kinase 5; Humans; Kinetics; Microscopy, Electron, Transmission; Mutation; Phosphorylation; Prions; Serine; Thiazoles | 2015 |
pH-induced structural change of a multi-tryptophan protein MPT63 with immunoglobulin-like fold: identification of perturbed tryptophan residue/residues.
Topics: Acrylamide; Amino Acid Motifs; Anilino Naphthalenesulfonates; Bacterial Proteins; Benzothiazoles; Cloning, Molecular; Escherichia coli; Fluorescent Dyes; Gene Expression; Hydrogen Bonding; Hydrogen-Ion Concentration; Immunoglobulins; Molecular Sequence Data; Mycobacterium tuberculosis; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Proteins; Spectrometry, Fluorescence; Static Electricity; Thermodynamics; Thiazoles; Tryptophan; Tyrosine | 2015 |
Phosphorylation as conformational switch from the native to amyloid state: Trp-cage as a protein aggregation model.
Topics: Amino Acid Sequence; Amyloid; Benzothiazoles; Circular Dichroism; Magnetic Resonance Spectroscopy; Microscopy, Electron, Transmission; Molecular Dynamics Simulation; Molecular Sequence Data; Peptides; Phosphorylation; Protein Conformation; Protein Folding; Protein Multimerization; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2015 |
Rationally designed peptidomimetic modulators of aβ toxicity in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Autophagy; Benzothiazoles; Biological Assay; Circular Dichroism; Drug Design; Green Fluorescent Proteins; Humans; Kinetics; Microscopy, Fluorescence; Models, Biological; Peptide Fragments; Peptidomimetics; Protein Aggregates; Proteolysis; Saccharomyces cerevisiae; Thiazoles | 2015 |
Metal ion mediated transition from random coil to β-sheet and aggregation of Bri2-23, a natural inhibitor of Aβ aggregation.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Benzothiazoles; Calorimetry; Circular Dichroism; Furin; Ions; Magnetic Resonance Spectroscopy; Metals; Molecular Dynamics Simulation; Molecular Sequence Data; Peptides; Potentiometry; Protein Aggregates; Protein Structure, Secondary; Spectrometry, Fluorescence; Spectrometry, Mass, Electrospray Ionization; Thiazoles | 2015 |
Steady-state and time-resolved Thioflavin-T fluorescence can report on morphological differences in amyloid fibrils formed by Aβ(1-40) and Aβ(1-42).
Topics: Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Molecular Sequence Data; Peptide Fragments; Protein Conformation; Spectrometry, Fluorescence; Thiazoles | 2015 |
Mechanism of initiation of aggregation of p53 revealed by Φ-value analysis.
Topics: Benzothiazoles; Biophysical Phenomena; Computer Simulation; Kinetics; Mutant Proteins; Protein Aggregates; Protein Structure, Tertiary; Thiazoles; Tumor Suppressor Protein p53 | 2015 |
Propagation of aggregated p53: Cross-reaction and coaggregation vs. seeding.
Topics: Benzothiazoles; Computer Simulation; DNA-Binding Proteins; Kinetics; Mutant Proteins; Mutation; Nuclear Proteins; Protein Aggregates; Protein Multimerization; Protein Structure, Tertiary; Thiazoles; Time Factors; Tumor Protein p73; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2015 |
Stabilization of nontoxic Aβ-oligomers: insights into the mechanism of action of hydroxyquinolines in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Biophysics; Caenorhabditis elegans; Cells, Cultured; Cerebral Cortex; Chromatography, Gel; Clioquinol; Enzyme-Linked Immunosorbent Assay; Humans; Hydroxyquinolines; Mice; Microscopy, Electron; Neurons; Peptide Fragments; Protein Binding; Scattering, Small Angle; Thiazoles | 2015 |
Examination of Ataxin-3 (atx-3) Aggregation by Structural Mass Spectrometry Techniques: A Rationale for Expedited Aggregation upon Polyglutamine (polyQ) Expansion.
Topics: Ataxin-3; Benzothiazoles; Escherichia coli; Fluorescent Dyes; Gene Expression; Humans; Mass Spectrometry; Models, Molecular; Peptides; Protein Aggregates; Protein Aggregation, Pathological; Protein Binding; Protein Interaction Domains and Motifs; Protein Structure, Secondary; Recombinant Proteins; Repressor Proteins; Spectrometry, Fluorescence; Thiazoles | 2015 |
Thioflavin T effect in diabetic Wistar rats: reporting the antihyperglycemic property of an amyloid probing dye.
Topics: alpha-Amylases; Animals; Benzothiazoles; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drinking; Eating; Fluorescent Dyes; Hypoglycemic Agents; Lipids; Male; Rats; Streptozocin; Thiazoles; Urine | 2015 |
Biophysical comparison of soluble amyloid-β(1-42) protofibrils, oligomers, and protofilaments.
Topics: Amyloid; Amyloid beta-Peptides; Benzothiazoles; Chromatography, Gel; Circular Dichroism; Microscopy, Electron; Peptide Fragments; Protein Structure, Secondary; Scattering, Radiation; Solubility; Spectrometry, Fluorescence; Thiazoles | 2015 |
Tau assembly: the dominant role of PHF6 (VQIVYK) in microtubule binding region repeat R3.
Topics: Benzothiazoles; Dimerization; Humans; Mass Spectrometry; Microscopy, Electron, Transmission; Molecular Dynamics Simulation; Mutation; Protein Binding; tau Proteins; Thiazoles | 2015 |
Effect of acidic and basic pH on Thioflavin T absorbance and fluorescence.
Topics: Absorption, Radiation; Benzothiazoles; Fluorescence; Fluorescent Dyes; Hydrogen-Ion Concentration; Thiazoles; Ultraviolet Rays | 2015 |
Flavone derivatives as inhibitors of insulin amyloid-like fibril formation.
Topics: Amyloid; Benzothiazoles; Insulin; Polymerization; Thiazoles | 2015 |
All-atomic simulations on human telomeric G-quadruplex DNA binding with thioflavin T.
Topics: Benzothiazoles; Computer Simulation; DNA; G-Quadruplexes; Humans; Hydrogen Bonding; Models, Genetic; Molecular Dynamics Simulation; Potassium; Sodium; Telomere; Thiazoles | 2015 |
Using molecular rotors to probe gelation.
Topics: Benzothiazoles; Fluorescent Dyes; Glucose; Glucose Oxidase; Glycosuria; Humans; Hydrogel, Polyethylene Glycol Dimethacrylate; Protein Structure, Secondary; Spectrometry, Fluorescence; Thiazoles | 2015 |
Pseudocatalytic Antiaggregation Activity of Antibodies: Immunoglobulins can Influence α-Synuclein Aggregation at Substoichiometric Concentrations.
Topics: alpha-Synuclein; Antibodies; Benzothiazoles; Biocatalysis; Biological Assay; Circular Dichroism; Fluorescence; Kinetics; Protein Aggregates; Protein Aggregation, Pathological; Thiazoles | 2016 |
G4-quartet·M(+) borate hydrogels.
Topics: Benzothiazoles; Borates; Fluorescence; Guanosine; Hydrogels; Magnetic Resonance Spectroscopy; Metals, Alkali; Molecular Structure; Organometallic Compounds; Protons; Thiazoles | 2015 |
Thioflavin T as a fluorescence probe for monitoring RNA metabolism at molecular and cellular levels.
Topics: Adenosine Diphosphate; Benzothiazoles; Fluorescent Dyes; Polyribonucleotide Nucleotidyltransferase; RNA; RNA, Bacterial; Single-Cell Analysis; Thiazoles | 2015 |
Non-fluorinated cosolvents: A potent amorphous aggregate inducer of metalloproteinase-conalbumin (ovotransferrin).
Topics: Animals; Benzothiazoles; Conalbumin; Kinetics; Metalloproteases; Models, Molecular; Protein Aggregates; Protein Binding; Protein Conformation; Solvents; Spectrum Analysis; Thiazoles | 2015 |
pH-induced molecular shedding drives the formation of amyloid fibril-derived oligomers.
Topics: Amyloid; Amyloidosis; Benzothiazoles; beta 2-Microglobulin; Endosomes; HSP70 Heat-Shock Proteins; Humans; Hydrogen-Ion Concentration; Kinetics; Lysosomes; Monocytes; Muramidase; Protein Binding; Recombinant Proteins; Spectrometry, Fluorescence; Thiazoles | 2015 |
Zinc significantly changes the aggregation pathway and the conformation of aggregates of human prion protein.
Topics: Benzothiazoles; Humans; Prion Diseases; Prions; Protein Aggregates; Protein Conformation; Thiazoles; Zinc | 2015 |
The effects of ginsenosides to amyloid fibril formation by RCMκ-casein.
Topics: Amyloid; Benzothiazoles; Caseins; Ginsenosides; Microscopy, Electron, Transmission; Models, Chemical; Protein Stability; Solutions; Spectrometry, Fluorescence; Structure-Activity Relationship; Thiazoles | 2015 |
Fluorescent filter-trap assay for amyloid fibril formation kinetics in complex solutions.
Topics: Amyloid; Amyloid beta-Peptides; Benzothiazoles; Chemistry Techniques, Analytical; Escherichia coli; Fluorescent Dyes; Humans; Kinetics; Microscopy, Electron, Transmission; Nanoparticles; Peptide Fragments; Polystyrenes; Protein Multimerization; Serum Albumin; Solutions; Thiazoles | 2015 |
Generic amyloidogenicity of mammalian prion proteins from species susceptible and resistant to prions.
Topics: Amino Acid Sequence; Amyloid; Animals; Benzothiazoles; Circular Dichroism; Humans; Kinetics; Mammals; Molecular Sequence Data; Negative Staining; Prions; Protein Aggregates; Protein Folding; Species Specificity; Thiazoles; Time Factors | 2015 |
Interfacial force-driven pattern formation during drying of Aβ (25-35) fibrils.
Topics: Amyloid; Amyloid beta-Peptides; Benzothiazoles; Desiccation; Fluorescent Dyes; Humans; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Peptide Fragments; Thiazoles; Wettability | 2015 |
A label-free fluorescent biosensor for ultratrace detection of terbium (ш) based on structural conversion of G-quadruplex DNA mediated by ThT and terbium (ш).
Topics: Benzothiazoles; Biosensing Techniques; Cations; DNA; Environmental Monitoring; Fluorescent Dyes; G-Quadruplexes; Limit of Detection; Rivers; Spectrometry, Fluorescence; Terbium; Thiazoles | 2015 |
Adsorption and sub-nanomolar sensing of thioflavin T on colloidal gold nanoparticles, silver nanoparticles and silver-coated films studied using surface-enhanced Raman scattering.
Topics: Adsorption; Benzothiazoles; Electrons; Gold Colloid; Metal Nanoparticles; Molecular Conformation; Silver; Spectrophotometry, Ultraviolet; Spectrum Analysis, Raman; Thiazoles | 2015 |
Fluphenazine·HCl and Epigallocatechin Gallate Modulate the Rate of Formation and Structural Properties of Apolipoprotein C-II Amyloid Fibrils.
Topics: Amyloid; Antipsychotic Agents; Apolipoprotein C-II; Benzothiazoles; Binding, Competitive; Catechin; Drug Discovery; Drugs, Investigational; Fluphenazine; Humans; Kinetics; Microscopy, Electron, Transmission; Neuroprotective Agents; Particle Size; Protein Aggregates; Protein Conformation; Proteostasis Deficiencies; Recombinant Proteins; Small Molecule Libraries; Thiazoles; Ultracentrifugation | 2015 |
Anesthetic 2,2,2-trifluoroethanol induces amyloidogenesis and cytotoxicity in human serum albumin.
Topics: Anesthetics; Benzothiazoles; Comet Assay; Congo Red; Fluorescent Dyes; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Lymphocytes; Nucleic Acid Denaturation; Primary Cell Culture; Protein Aggregates; Protein Binding; Protein Folding; Protein Structure, Secondary; Serum Albumin; Solutions; Thiazoles; Trifluoroethanol | 2015 |
A Comparison of Three Fluorophores for the Detection of Amyloid Fibers and Prefibrillar Oligomeric Assemblies. ThT (Thioflavin T); ANS (1-Anilinonaphthalene-8-sulfonic Acid); and bisANS (4,4'-Dianilino-1,1'-binaphthyl-5,5'-disulfonic Acid).
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Anilino Naphthalenesulfonates; Benzothiazoles; Diabetes Mellitus, Type 2; Fluorescent Dyes; Humans; Islet Amyloid Polypeptide; Molecular Sequence Data; Spectrometry, Fluorescence; Thiazoles | 2015 |
Thioflavin T templates amyloid β(1-40) conformation and aggregation pathway.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Benzothiazoles; Fluorescence Recovery After Photobleaching; Fluorescent Dyes; Humans; Molecular Dynamics Simulation; Molecular Sequence Data; Peptide Fragments; Protein Aggregates; Protein Aggregation, Pathological; Protein Conformation; Protein Multimerization; Protein Stability; Protein Structure, Secondary; Thiazoles | 2015 |
Oligo(p-phenylene ethynylene) Electrolytes: A Novel Molecular Scaffold for Optical Tracking of Amyloids.
Topics: Amyloid; Benzothiazoles; Circular Dichroism; Electrolytes; Fluorescent Dyes; Kinetics; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Molecular Structure; Muramidase; Optical Imaging; Polymers; Spectrophotometry; Thiazoles | 2015 |
Cu(II) promotes amyloid pore formation.
Topics: alpha-Synuclein; Amyloid; Benzothiazoles; Cations, Divalent; Copper; Flavanones; Humans; Kinetics; Microscopy, Electron, Transmission; Oxidation-Reduction; Protein Aggregates; Protein Structure, Secondary; Recombinant Proteins; Spectrometry, Fluorescence; Thiazoles | 2015 |
Chiral Metallo-Supramolecular Complex Directed Enantioselective Self-Assembly of β-Sheet Breaker Peptide for Amyloid Inhibition.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Humans; Kinetics; Metal Nanoparticles; Metals; Nanotechnology; PC12 Cells; Protein Structure, Secondary; Rats; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Stereoisomerism; Temperature; Thiazoles | 2015 |
Thioflavin T as an Efficient G-Quadruplex Inducer for the Highly Sensitive Detection of Thrombin Using a New Föster Resonance Energy Transfer System.
Topics: Benzothiazoles; Biosensing Techniques; DNA; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; G-Quadruplexes; Reproducibility of Results; Sensitivity and Specificity; Thiazoles; Thrombin | 2015 |
Amyloidogenic Mutation Promotes Fibril Formation of the N-terminal Apolipoprotein A-I on Lipid Membranes.
Topics: Amyloid; Apolipoprotein A-I; Benzothiazoles; Escherichia coli; Fluorescent Dyes; Gene Expression; Humans; Mutation; Phosphatidylcholines; Protein Binding; Protein Engineering; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Fusion Proteins; Structure-Activity Relationship; Thiazoles; Trifluoroethanol; Unilamellar Liposomes | 2015 |
Curcumin Protects β-Lactoglobulin Fibril Formation and Fibril-Induced Neurotoxicity in PC12 Cells.
Topics: Aflatoxin M1; Animals; Benzothiazoles; Cattle; Cell Death; Cell Differentiation; Circular Dichroism; Curcumin; Hydrogen-Ion Concentration; Lactoglobulins; Lead; Microscopy, Atomic Force; Microscopy, Fluorescence; Neurites; Neuroprotection; Neuroprotective Agents; Neurotoxins; PC12 Cells; Protein Structure, Secondary; Rats; Reactive Oxygen Species; Spectrometry, Fluorescence; Thiazoles | 2015 |
Molecular Rotors Provide Insights into Microscopic Structural Changes During Protein Aggregation.
Topics: Amyloid; Animals; Benzothiazoles; Carbocyanines; Cattle; Chickens; Egg Proteins; Gels; Insulin; Microfluidics; Microscopy, Fluorescence, Multiphoton; Muramidase; Phase Transition; Protein Multimerization; Protein Structure, Secondary; Solubility; Solutions; Thiazoles; Viscosity | 2015 |
Development of a Transgenic Mouse with R124H Human TGFBI Mutation Associated with Granular Corneal Dystrophy Type 2.
Topics: Alleles; Animals; Base Sequence; Benzothiazoles; Corneal Dystrophies, Hereditary; Disease Models, Animal; DNA Primers; DNA, Complementary; Female; Genotype; Heterozygote; Homozygote; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Transgenic; Microscopy, Electron; Microtubule-Associated Proteins; Mutation; Phenotype; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Transforming Growth Factor beta1 | 2015 |
Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Carbon-13 Magnetic Resonance Spectroscopy; Disease Models, Animal; Drug Monitoring; Fluorescent Dyes; Humans; Mice, Transgenic; Molecular Imaging; Photons; Presenilin-1; Proton Magnetic Resonance Spectroscopy; Spectrometry, Fluorescence; Spectroscopy, Near-Infrared; Thiazoles; Tissue Extracts; Titrimetry | 2015 |
Inhibition of insulin amyloid fibril formation by cyclodextrins.
Topics: Amino Acid Sequence; Amino Acid Substitution; Amyloid; Benzothiazoles; Cyclodextrins; Fluorescent Dyes; Humans; Insulin; Insulin Aspart; Insulin Detemir; Kinetics; Models, Molecular; Molecular Sequence Data; Recombinant Proteins; Solutions; Spectrometry, Fluorescence; Thiazoles | 2015 |
Real-Time Monitoring of Alzheimer's-Related Amyloid Aggregation via Probe Enhancement-Fluorescence Correlation Spectroscopy.
Topics: Acrylamides; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Fluorescent Dyes; Kinetics; Molecular Structure; Naphthalenes; Peptide Fragments; Protein Aggregates; Solubility; Spectrometry, Fluorescence; Thiazoles | 2015 |
Ratiometric fluorescence detection of silver ions using thioflavin T-based organic/inorganic hybrid supraparticles.
Topics: Anions; Benzothiazoles; Cations; Iodides; Nanoparticles; Silver; Spectrometry, Fluorescence; Thiazoles; Water | 2015 |
Insulin-degrading enzyme prevents α-synuclein fibril formation in a nonproteolytical manner.
Topics: alpha-Synuclein; Amyloid; Benzothiazoles; Calorimetry; Insulysin; Microscopy, Atomic Force; Protein Multimerization; Thiazoles | 2015 |
Inhibiting amyloid β-protein assembly: Size-activity relationships among grape seed-derived polyphenols.
Topics: Amyloid beta-Peptides; Animals; Benzothiazoles; Circular Dichroism; Cross-Linking Reagents; Fluorescent Dyes; Mice; Models, Molecular; Molecular Weight; Neurofibrillary Tangles; Polyphenols; Protein Conformation; Seeds; Structure-Activity Relationship; Thiazoles; Vitis | 2015 |
Quantification of amyloid fibrils using size exclusion chromatography coupled with online fluorescence and ultraviolet detection.
Topics: Algorithms; Amyloid; Animals; Bacillus; Bacterial Proteins; Benzothiazoles; Biofilms; Calibration; Caseins; Cattle; Chromatography, Gel; Fluorescent Dyes; France; Models, Molecular; Molecular Weight; Protein Aggregates; Protein Aggregation, Pathological; Solubility; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Thiazoles | 2015 |
Ultrafast fluorescence spectroscopy reveals a dominant weakly-emissive population of fibril bound thioflavin-T.
Topics: Amyloid; Benzothiazoles; Fluorescent Dyes; Insulin; Molecular Structure; Protein Binding; Sensitivity and Specificity; Spectrometry, Fluorescence; Thiazoles | 2015 |
Intracoronary Infusion of Thioflavin-S to Study Microvascular Obstruction in a Model of Myocardial Infarction.
Topics: Animals; Benzothiazoles; Coronary Angiography; Coronary Circulation; Coronary Occlusion; Coronary Vessels; Disease Models, Animal; Fluorescent Dyes; Infusions, Intra-Arterial; Microcirculation; Microvessels; Myocardial Infarction; Myocardial Reperfusion Injury; Photography; Sus scrofa; Swine; Thiazoles; Ultraviolet Rays | 2015 |
Endoplasmic reticulum stress in diabetic mouse or glycated LDL-treated endothelial cells: protective effect of Saskatoon berry powder and cyanidin glycans.
Topics: Animals; Anthocyanins; Benzothiazoles; Diabetes Mellitus, Experimental; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Endothelium, Vascular; Galactosides; Glucosides; Heart; Humans; Lipoproteins, LDL; Male; Mice, Inbred C57BL; Powders; Protective Agents; Rosaceae; Thiazoles; Transcription Factor CHOP; Unfolded Protein Response; X-Box Binding Protein 1 | 2015 |
Enhanced molecular mobility of ordinarily structured regions drives polyglutamine disease.
Topics: Alanine; Allosteric Site; Amyloidogenic Proteins; Ataxin-3; Benzothiazoles; Catalytic Domain; Chromatography, High Pressure Liquid; Disease Progression; Escherichia coli; Genetic Variation; Humans; Machado-Joseph Disease; Microscopy, Electron, Transmission; Mutagenesis; Peptide Mapping; Peptides; Protein Binding; Protein Folding; Protein Structure, Secondary; Tandem Mass Spectrometry; Thiazoles | 2015 |
Investigation of the Binding Profiles of AZD2184 and Thioflavin T with Amyloid-β(1-42) Fibril by Molecular Docking and Molecular Dynamics Methods.
Topics: Alzheimer Disease; Aminopyridines; Amyloid beta-Peptides; Benzothiazoles; Drug Design; Elasticity; Fluorescent Dyes; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Peptide Fragments; Positron-Emission Tomography; Protein Binding; Radiopharmaceuticals; Static Electricity; Thiazoles | 2015 |
Curcumin promotes fibril formation in F isomer of human serum albumin via amorphous aggregation.
Topics: Amyloid; Benzothiazoles; Circular Dichroism; Curcumin; Humans; Isomerism; Kinetics; Microscopy, Electron, Transmission; Protein Binding; Protein Stability; Protein Structure, Secondary; Protein Structure, Tertiary; Serum Albumin; Temperature; Thiazoles | 2015 |
Anthocyanin suppresses the toxicity of Aβ deposits through diversion of molecular forms in in vitro and in vivo models of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Anthocyanins; Benzothiazoles; Brain; Cell Line, Tumor; Cognition; Cognition Disorders; Female; Humans; Male; Mice; Microscopy, Atomic Force; Peptide Fragments; Plant Extracts; Polyphenols; Thiazoles; Vaccinium myrtillus | 2016 |
Modulation of Amyloid-β Fibrils into Mature Microrod-Shaped Structure by Histidine Functionalized Water-Soluble Perylene Diimide.
Topics: Amyloid beta-Peptides; Benzothiazoles; Dynamic Light Scattering; Fluorescence Resonance Energy Transfer; Histidine; Human Umbilical Vein Endothelial Cells; Humans; Imides; Microscopy, Atomic Force; Perylene; Protein Aggregates; Solubility; Spectroscopy, Fourier Transform Infrared; Thiazoles; Water | 2015 |
A novel antagonistic role of natural compound icariin on neurotoxicity of amyloid β peptide.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Benzothiazoles; Cell Line; Cell Survival; Flavonoids; Humans; Hydrogen Peroxide; Microscopy, Electron, Transmission; Neurons; Peptide Fragments; Protein Aggregation, Pathological; Thiazoles | 2015 |
Label-free Detection of Zn(2+) Based on G-quadruplex.
Topics: Benzothiazoles; Biosensing Techniques; G-Quadruplexes; Humans; Limit of Detection; Telomere; Thiazoles; Zinc | 2015 |
Molecular "light switch" [Ru(phen)2dppzidzo](2+) monitoring the aggregation of tau.
Topics: Alzheimer Disease; Benzothiazoles; Fluorescent Dyes; Humans; Light; Luminescent Agents; Luminescent Measurements; Models, Molecular; Organometallic Compounds; Protein Aggregates; Protein Aggregation, Pathological; tau Proteins; Thiazoles | 2015 |
Tau Aggregation Propensity Engrained in Its Solution State.
Topics: Amino Acid Sequence; Benzothiazoles; Electron Spin Resonance Spectroscopy; Microscopy, Electron, Transmission; Molecular Sequence Data; Solutions; Spectrometry, Mass, Electrospray Ionization; tau Proteins; Thiazoles | 2015 |
Insulin Fibrillization at Acidic and Physiological pH Values is Controlled by Different Molecular Mechanisms.
Topics: Amyloid; Benzothiazoles; Humans; Hydrogen-Ion Concentration; Insulin; Temperature; Thiazoles | 2015 |
Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies.
Topics: Animals; Benzothiazoles; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fluorescent Dyes; High-Throughput Screening Assays; Humans; Mice; Microarray Analysis; Microscopy, Fluorescence; Molecular Structure; Neuroprotective Agents; Protein Aggregates; Protein Multimerization; tau Proteins; Tauopathies; Thiazoles | 2015 |
Oral Administration of Thioflavin T Prevents Beta Amyloid Plaque Formation in Double Transgenic AD Mice.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Benzothiazoles; Brain; Disease Models, Animal; Female; Male; Mice, Transgenic; Microglia; Neuroprotective Agents; Peptide Fragments; Plaque, Amyloid; Thiazoles | 2015 |
Unaided trifluoroacetic acid pretreatment solubilizes polyglutamine peptides and retains their biophysical properties of aggregation.
Topics: Benzothiazoles; Kinetics; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Peptides; Propanols; Protein Binding; Solubility; Spectroscopy, Fourier Transform Infrared; Thiazoles; Trifluoroacetic Acid | 2016 |
Bivalent ligands incorporating curcumin and diosgenin as multifunctional compounds against Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Cell Line, Tumor; Cell Survival; Curcumin; Diosgenin; Drug Design; Humans; Ligands; Neuroprotective Agents; Reactive Oxygen Species; Thiazoles | 2015 |
Mammalian prion protein (PrP) forms conformationally different amyloid intracellular aggregates in bacteria.
Topics: Amyloid; Animals; Bacteria; Benzothiazoles; Endopeptidase K; Escherichia coli; Inclusion Bodies; Mice; Microscopy, Electron, Transmission; Prions; Protein Binding; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Proteins; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2015 |
Detection and Monitoring of Amyloid Fibrillation Using a Fluorescence "Switch-On" Probe.
Topics: Amyloid; Animals; Aspartic Acid; Benzothiazoles; Cattle; Chickens; Fluorescence; Fluorescent Dyes; Kinetics; Nanoparticles; Peptides; Spectrometry, Fluorescence; Thiazoles | 2015 |
Insights into Kinetics of Agitation-Induced Aggregation of Hen Lysozyme under Heat and Acidic Conditions from Various Spectroscopic Methods.
Topics: Acrylamide; Amyloid; Animals; Benzothiazoles; Chickens; Chromatography, High Pressure Liquid; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Light; Microscopy, Atomic Force; Muramidase; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Scattering, Radiation; Spectrophotometry; Spectroscopy, Fourier Transform Infrared; Thiazoles; Time Factors; Tryptophan | 2015 |
Heterogeneity and Turnover of Intermediates during Amyloid-β (Aβ) Peptide Aggregation Studied by Fluorescence Correlation Spectroscopy.
Topics: Amyloid beta-Peptides; Benzothiazoles; Humans; Peptide Fragments; Protein Aggregates; Spectrometry, Fluorescence; Thiazoles | 2015 |
Thioflavin T as a fluorescence probe for label-free detection of T4 polynucleotide kinase/phosphatase and its inhibitors.
Topics: Bacterial Proteins; Bacteriophage T4; Benzothiazoles; Enzyme Inhibitors; Fluorescent Dyes; Polynucleotide 5'-Hydroxyl-Kinase; Thiazoles | 2015 |
Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson's disease genetically related mutants.
Topics: alpha-Synuclein; Amino Acid Sequence; Benzothiazoles; Biological Assay; Fluorescence Resonance Energy Transfer; Humans; Kinetics; Molecular Sequence Data; Mutant Proteins; Mutation, Missense; Parkinson Disease; Protein Multimerization; Thiazoles | 2015 |
Deep clinical and neuropathological phenotyping of Pick disease.
Topics: Aged; Aged, 80 and over; Benzothiazoles; Cerebral Cortex; Female; Humans; Immunohistochemistry; Limbic System; Magnetic Resonance Imaging; Male; Middle Aged; Phenotype; Pick Disease of the Brain; Staining and Labeling; tau Proteins; Thiazoles | 2016 |
High-content analysis of α-synuclein aggregation and cell death in a cellular model of Parkinson's disease.
Topics: alpha-Synuclein; Apoptosis; Benzothiazoles; Blotting, Western; Cell Count; Cell Culture Techniques; Cell Line, Tumor; Cell Survival; Genetic Vectors; Humans; Image Processing, Computer-Assisted; Immunohistochemistry; Indoles; Lentivirus; Microscopy, Fluorescence; Oxidative Stress; Parkinsonian Disorders; Protein Aggregation, Pathological; Protein Multimerization; Software; Thiazoles | 2016 |
High Fluorescence Anisotropy of Thioflavin T in Aqueous Solution Resulting from Its Molecular Rotor Nature.
Topics: Anisotropy; Benzothiazoles; Fluorescence; Solutions; Spectrometry, Fluorescence; Thiazoles; Time Factors; Water | 2016 |
Difficulties associated with the structural analysis of proteins susceptible to form aggregates: The case of Tau protein as a biomarker of Alzheimer's disease.
Topics: Adhesiveness; Adsorption; Alzheimer Disease; Amino Acid Motifs; Antibodies, Monoclonal; Benzothiazoles; Biomarkers; Chymotrypsin; Epitopes; Humans; Magnetics; Mass Spectrometry; Proteolysis; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; tau Proteins; Thiazoles; Trypsin | 2016 |
Growth differentiation factor 15 may protect the myocardium from no‑reflow by inhibiting the inflammatory‑like response that predominantly involves neutrophil infiltration.
Topics: Animals; Benzothiazoles; Cardiotonic Agents; Enzyme-Linked Immunosorbent Assay; Growth Differentiation Factor 15; Inflammation; Intercellular Adhesion Molecule-1; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Neutrophil Infiltration; No-Reflow Phenomenon; Peroxidase; Rats, Wistar; RNA, Messenger; Thiazoles; Time Factors | 2016 |
Effects of Charged Cholesterol Derivatives on Aβ40 Amyloid Formation.
Topics: Amyloid beta-Peptides; Benzothiazoles; Cholesterol; Kinetics; Micelles; Thiazoles | 2016 |
Differential Effects of Structural Modifications on the Competition of Chalcones for the PIB Amyloid Imaging Ligand-Binding Site in Alzheimer's Disease Brain and Synthetic Aβ Fibrils.
Topics: Aged; Alkenes; Alzheimer Disease; Amyloid beta-Peptides; Amyloidogenic Proteins; Aniline Compounds; Benzoates; Benzothiazoles; Binding Sites; Brain; Chalcones; Female; Fluorescent Dyes; Humans; Ligands; Peptide Fragments; Positron-Emission Tomography; Thiazoles; Tritium | 2016 |
Effects of macromolecular crowding and osmolyte on human Tau fibrillation.
Topics: Benzothiazoles; Dextrans; Electrophoresis, Polyacrylamide Gel; Ficoll; Fluorescence; Humans; Macromolecular Substances; Models, Biological; Phosphorylation; Solutions; Sucrose; tau Proteins; Thiazoles; Time Factors | 2016 |
Analysis of the Amyloidogenic Potential of Pufferfish (Takifugu rubripes) Islet Amyloid Polypeptide Highlights the Limitations of Thioflavin-T Assays and the Difficulties in Defining Amyloidogenicity.
Topics: Amino Acid Sequence; Amyloid; Animals; Benzothiazoles; Biological Assay; Buffers; Fish Proteins; Fluorescent Dyes; Humans; Islet Amyloid Polypeptide; Molecular Dynamics Simulation; Molecular Sequence Data; Protein Binding; Species Specificity; Tetraodontiformes; Thiazoles | 2016 |
Dynamic Assembly and Disassembly of Functional β-Endorphin Amyloid Fibrils.
Topics: Amyloid; Benzothiazoles; beta-Endorphin; Carbohydrates; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Protein Aggregates; Thiazoles | 2016 |
How the imidazole ring modulates amyloid formation of islet amyloid polypeptide: A chemical modification study.
Topics: Benzothiazoles; Diethyl Pyrocarbonate; Humans; Imidazoles; Islet Amyloid Polypeptide; Molecular Dynamics Simulation; Multiprotein Complexes; Protein Structure, Secondary; Thiazoles | 2016 |
Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids.
Topics: Aged; Aged, 80 and over; Amyloidogenic Proteins; Benzothiazoles; Circular Dichroism; Diagnostic Imaging; Female; Humans; Male; Microscopy, Atomic Force; Microscopy, Fluorescence; Middle Aged; Parkinson Disease; Thiazoles | 2016 |
Inhibition of hIAPP Amyloid Aggregation and Pancreatic β-Cell Toxicity by OH-Terminated PAMAM Dendrimer.
Topics: Amyloid; Benzothiazoles; Cell Death; Cytoprotection; Dendrimers; Humans; Hydroxylation; Insulin-Secreting Cells; Islet Amyloid Polypeptide; Models, Molecular; Protein Aggregates; Protein Multimerization; Thiazoles | 2016 |
Bioactive polyphenol interactions with β amyloid: a comparison of binding modelling, effects on fibril and aggregate formation and neuroprotective capacity.
Topics: Amyloid beta-Peptides; Animals; Benzothiazoles; Biphenyl Compounds; Cell Survival; Flavonoids; Fluorescent Dyes; Hydrolyzable Tannins; Lignans; Luteolin; Microscopy, Electron, Transmission; Neuroprotective Agents; PC12 Cells; Peptide Fragments; Polyphenols; Rats; Thiazoles | 2016 |
"Molecular beacon"-hosted thioflavin T: Applications for label-free fluorescent detection of iodide and logic operations.
Topics: Benzothiazoles; Biosensing Techniques; DNA; Fluorescent Dyes; Humans; Iodides; Mercury; Spectrometry, Fluorescence; Thiazoles | 2016 |
Label-free monitoring of DNA methyltransferase activity based on terminal deoxynucleotidyl transferase using a thioflavin T probe.
Topics: Benzothiazoles; Biosensing Techniques; DNA Nucleotidylexotransferase; DNA-Cytosine Methylases; Fluorescence; Thiazoles | 2016 |
Visualization of microbleeds with optical histology in mouse model of cerebral amyloid angiopathy.
Topics: Animals; Benzothiazoles; Carbocyanines; Cerebral Amyloid Angiopathy; Cerebral Hemorrhage; Cerebrovascular Circulation; Disease Models, Animal; Fluorescent Dyes; Genetic Predisposition to Disease; Imaging, Three-Dimensional; Mice, Transgenic; Microcirculation; Microscopy, Confocal; Microvessels; Optical Imaging; Plaque, Amyloid; Staining and Labeling; Thiazoles | 2016 |
The Inhibitory Effect of Natural Products on Protein Fibrillation May Be Caused by Degradation Products--A Study Using Aloin and Insulin.
Topics: Anthraquinones; Benzothiazoles; Biological Products; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Emodin; Excipients; Fluorescent Dyes; Glucosides; Insulin; Microscopy, Electron, Transmission; Oxidation-Reduction; Protein Stability; Proteolysis; Solutions; Spectrometry, Fluorescence; Thiazoles | 2016 |
Conformational Compatibility Is Essential for Heterologous Aggregation of α-Synuclein.
Topics: alpha-Synuclein; Amino Acid Sequence; Amyloid; Benzothiazoles; Circular Dichroism; Humans; Microscopy, Atomic Force; Molecular Conformation; Thiazoles | 2016 |
Fluorescent H-Aggregates Hosted by a Charged Cyclodextrin Cavity.
Topics: Benzothiazoles; beta-Cyclodextrins; Coloring Agents; Cyclodextrins; Fluorescent Dyes; Kinetics; Thiazoles | 2016 |
A High Affinity Red Fluorescence and Colorimetric Probe for Amyloid β Aggregates.
Topics: Absorption, Radiation; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Colorimetry; Fluorescent Dyes; Fluorometry; Humans; Molecular Docking Simulation; Molecular Structure; Peptide Fragments; Protein Aggregation, Pathological; Thiazoles | 2016 |
Rigid Organization of Fluorescence-Active Ligands by Artificial Macrocyclic Receptor to Achieve the Thioflavin T-Amyloid Fibril Level Association.
Topics: Amyloid; Benzothiazoles; Fluorescence; Fluorescent Dyes; Ligands; Molecular Conformation; Quantum Theory; Receptors, Artificial; Thiazoles | 2016 |
Thioflavin T as an efficient fluorescence sensor for selective recognition of RNA G-quadruplexes.
Topics: Base Sequence; Benzothiazoles; Biosensing Techniques; Fluorescence; Fluorescent Dyes; G-Quadruplexes; Molecular Structure; RNA; Spectrum Analysis; Thiazoles | 2016 |
Methionine oxidation reduces lag-times for amyloid-β(1-40) fiber formation but generates highly fragmented fibers.
Topics: Amyloid; Amyloid beta-Peptides; Benzothiazoles; Humans; Hydrogen Peroxide; Kinetics; Methionine; Microscopy, Electron, Transmission; Oxidation-Reduction; Peptide Fragments; Solutions; Spectrometry, Fluorescence; Thiazoles | 2016 |
Surfactant-mediated amyloidogenesis behavior of stem bromelain; a biophysical insight.
Topics: Amyloid; Anilino Naphthalenesulfonates; Benzothiazoles; Bromelains; Cetrimonium; Cetrimonium Compounds; Coloring Agents; Congo Red; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Protein Aggregates; Protein Binding; Quaternary Ammonium Compounds; Static Electricity; Surface-Active Agents; Thiazoles | 2017 |
Aggregation of intrinsically disordered fibrinogen as the influence of backbone conformation.
Topics: Benzothiazoles; Blood Coagulation; Circular Dichroism; Congo Red; Fibrinogen; Fibrinolysis; Humans; Hydrophobic and Hydrophilic Interactions; Intrinsically Disordered Proteins; Kinetics; Microscopy, Atomic Force; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Scattering, Radiation; Spectroscopy, Fourier Transform Infrared; Thermodynamics; Thiazoles | 2016 |
Binding Modes of Thioflavin T on the Surface of Amyloid Fibrils Studied by NMR.
Topics: Amyloid; Benzothiazoles; Binding Sites; Fluorescent Dyes; Proton Magnetic Resonance Spectroscopy; Surface Properties; Thiazoles | 2016 |
Solid-Phase Synthesis and Characterization of N-Terminally Elongated Aβ-3-x -Peptides.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Benzothiazoles; Circular Dichroism; Humans; Kinetics; Mass Spectrometry; Microscopy, Electron; Nuclear Magnetic Resonance, Biomolecular; Solid-Phase Synthesis Techniques; Thiazoles | 2016 |
Hydrophobic tail length plays a pivotal role in amyloid beta (25-35) fibril-surfactant interactions.
Topics: Amyloid beta-Peptides; Benzothiazoles; Cetrimonium; Cetrimonium Compounds; Hydrophobic and Hydrophilic Interactions; Micelles; Models, Molecular; Octoxynol; Peptide Fragments; Quaternary Ammonium Compounds; Sodium Dodecyl Sulfate; Spectrometry, Fluorescence; Surface-Active Agents; Thiazoles | 2016 |
A label-free fluorescent adenosine triphosphate biosensor via overhanging aptamer-triggered enzyme protection and target recycling amplification.
Topics: Adenosine Triphosphate; Aptamers, Nucleotide; Benzothiazoles; Biosensing Techniques; Exodeoxyribonucleases; Humans; Thiazoles | 2016 |
Stoichiometry and Affinity of Thioflavin T Binding to Sup35p Amyloid Fibrils.
Topics: Amyloid; Benzothiazoles; Fluorescence; Fluorescent Dyes; Kinetics; Peptide Termination Factors; Protein Binding; Saccharomyces cerevisiae Proteins; Thiazoles | 2016 |
A dimer model of human calcitonin13-32 forms an α-helical structure and robustly aggregates in 50% aqueous 2,2,2-trifluoroethanol solution.
Topics: Amino Acid Sequence; Benzothiazoles; Calcitonin; Calcitonin Gene-Related Peptide; Fluorenes; Humans; Microscopy, Atomic Force; Models, Molecular; Protein Aggregates; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Multimerization; Solid-Phase Synthesis Techniques; Solutions; Spectrometry, Fluorescence; Thiazoles; Trifluoroethanol; Water | 2016 |
Supramolecular Nanostructure Formation of Coassembled Amyloid Inspired Peptides.
Topics: Amyloid; Benzothiazoles; Models, Molecular; Nanostructures; Peptides; Scattering, Small Angle; Thiazoles; X-Ray Diffraction | 2016 |
Hopeahainol A binds reversibly at the acetylcholinesterase (AChE) peripheral site and inhibits enzyme activity with a novel higher order concentration dependence.
Topics: Acetylcholinesterase; Benzothiazoles; Binding Sites; Catalytic Domain; Cholinesterase Inhibitors; Dipterocarpaceae; Edrophonium; Heterocyclic Compounds, 4 or More Rings; Kinetics; Molecular Docking Simulation; Plant Bark; Substrate Specificity; Thermodynamics; Thiazoles | 2016 |
Impact of Deuteration on the Assembly Kinetics of Transthyretin Monitored by Native Mass Spectrometry and Implications for Amyloidoses.
Topics: Amyloidosis; Benzothiazoles; Crystallography, X-Ray; Fluorescence; Fluorescent Dyes; Humans; Isotope Labeling; Kinetics; Mass Spectrometry; Models, Molecular; Prealbumin; Thiazoles | 2016 |
Piceatannol and Other Wine Stilbenes: A Pool of Inhibitors against α-Synuclein Aggregation and Cytotoxicity.
Topics: alpha-Synuclein; Animals; Benzothiazoles; Cell Survival; Electrophoresis, Polyacrylamide Gel; Flavonoids; Microscopy, Electron, Transmission; Parkinson Disease; PC12 Cells; Phenols; Rats; Stilbenes; Thiazoles; Wine | 2016 |
Peptide Inhibitors of the amyloidogenesis of IAPP: verification of the hairpin-binding geometry hypothesis.
Topics: Benzothiazoles; Circular Dichroism; Humans; Insulin; Islet Amyloid Polypeptide; Peptides; Protein Aggregation, Pathological; Protein Binding; Protein Conformation; Thiazoles | 2016 |
Thioflavin T-Silent Denaturation Intermediates Support the Main-Chain-Dominated Architecture of Amyloid Fibrils.
Topics: Amyloid; Animals; Benzothiazoles; beta 2-Microglobulin; Cell Survival; Guanidine; Humans; Insulin; PC12 Cells; Protein Aggregates; Protein Denaturation; Protein Structure, Secondary; Rats; Thiazoles; Ultrasonic Waves | 2016 |
Effect of peroxynitrite on human serum albumin: a multi technique approach.
Topics: Benzothiazoles; Binding Sites; Electrophoresis, Polyacrylamide Gel; Humans; Microscopy, Electron, Scanning; Peroxynitrous Acid; Protein Aggregates; Protein Binding; Serum Albumin, Human; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrum Analysis; Thiazoles | 2017 |
Fullerenol C60(OH)16 prevents amyloid fibrillization of Aβ40-in vitro and in silico approach.
Topics: Alzheimer Disease; Amyloid; Amyloidogenic Proteins; Benzothiazoles; Computer Simulation; Fullerenes; Thiazoles | 2016 |
Solvent Polarity Effect on Nonradiative Decay Rate of Thioflavin T.
Topics: Benzothiazoles; Fluorescence; Quantum Theory; Solvents; Temperature; Thiazoles; Viscosity | 2016 |
Mechanistic study of the inhibitory activity of Geum urbanum extract against α-Synuclein fibrillation.
Topics: alpha-Synuclein; Amyloid; Benzothiazoles; Geum; Humans; Plant Extracts; Protein Aggregates; Solutions; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2016 |
Notch1 hallmarks fibrillary depositions in sporadic Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Benzothiazoles; Biomarkers; Blotting, Western; Cell Line, Tumor; Cerebral Cortex; Disease Models, Animal; Female; Hippocampus; Humans; Immunohistochemistry; Liver; Male; Mice; Middle Aged; Plaque, Amyloid; Receptor, Notch1; tau Proteins; Thiazoles | 2016 |
Timesaving microwave assisted synthesis of insulin amyloid fibrils with enhanced nanofiber aspect ratio.
Topics: Amyloid; Animals; Benzothiazoles; Cattle; Insulin; Microscopy, Atomic Force; Microwaves; Nanofibers; Protein Structure, Secondary; Solubility; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiazoles; Time Factors | 2016 |
Thioflavin T: Electronic Circular Dichroism and Circularly Polarized Luminescence Induced by Amyloid Fibrils.
Topics: Amyloid; Benzothiazoles; Circular Dichroism; Luminescent Measurements; Quantum Theory; Thiazoles | 2016 |
Biophysical insights into the interaction of hen egg white lysozyme with therapeutic dye clofazimine: modulation of activity and SDS induced aggregation of model protein.
Topics: Amyloid; Animals; Benzothiazoles; Binding Sites; Chickens; Clofazimine; Egg White; Fluorescent Dyes; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Leprostatic Agents; Molecular Docking Simulation; Muramidase; Protein Aggregates; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Sodium Dodecyl Sulfate; Thiazoles | 2017 |
Structural Polymorphism of Alzheimer's β-Amyloid Fibrils as Controlled by an E22 Switch: A Solid-State NMR Study.
Topics: Amyloid beta-Peptides; Benzothiazoles; Binding Sites; Guanidine; Humans; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Mutation; Peptides; Phenotype; Protein Conformation; Temperature; Thiazoles | 2016 |
The structural alteration and aggregation propensity of glycated lens crystallins in the presence of calcium: Importance of lens calcium homeostasis in development of diabetic cataracts.
Topics: Animals; Benzothiazoles; Calcium; Cataract; Cattle; Chymotrypsin; Circular Dichroism; Cross-Linking Reagents; Crystallins; Diabetes Mellitus; Dynamic Light Scattering; Fluorescence; Glycosylation; Homeostasis; Ions; Kinetics; Lens, Crystalline; Molecular Weight; Protein Aggregates; Protein Conformation; Protein Stability; Proteolysis; Thiazoles; Tryptophan | 2017 |
Surface Roughness Modulates Diffusion and Fibrillation of Amyloid-β Peptide.
Topics: Amyloid beta-Peptides; Benzothiazoles; Humans; Microscopy, Atomic Force; Surface Properties; Thiazoles | 2016 |
Amyloid-like aggregates formation by bovine apo-carbonic anhydrase in various alcohols: A comparative study.
Topics: Alcohols; Amyloid; Animals; Benzothiazoles; Carbonic Anhydrases; Cattle; Dynamic Light Scattering; Hydrodynamics; Hydrophobic and Hydrophilic Interactions; Kinetics; Microscopy, Atomic Force; Protein Aggregates; Solutions; Thiazoles; Time Factors; Trifluoroethanol | 2016 |
Amyloid-like Self-Assembly of a Cellular Compartment.
Topics: Amyloid; Animals; Benzothiazoles; Female; Fluorescent Dyes; Mitochondria; Oocytes; Organelle Biogenesis; Organelles; Prions; Protein Domains; Protein Transport; Recombinant Fusion Proteins; RNA, Messenger; Sf9 Cells; T-Box Domain Proteins; Thiazoles; Xenopus laevis; Xenopus Proteins; Zebrafish | 2016 |
Protein Aggregate-Ligand Binding Assays Based on Microfluidic Diffusional Separation.
Topics: Amyloid; Benzothiazoles; Binding Sites; Diffusion; Humans; Kinetics; Ligands; Microfluidic Analytical Techniques; Nanoparticles; Particle Size; Protein Aggregates; Proteostasis Deficiencies; Thiazoles | 2016 |
Real-time monitoring of amyloid growth in a rigid gel matrix.
Topics: Amyloid; Animals; Benzothiazoles; Caseins; Gelatin; Gels; Humans; Kinetics; Protein Aggregation, Pathological; Thiazoles | 2016 |
Label-free thioflavin T/G-quadruplex-based real-time strand displacement amplification for biosensing applications.
Topics: Benzothiazoles; Biosensing Techniques; Computer Systems; DNA Probes; Equipment Design; Equipment Failure Analysis; Fluorescent Dyes; G-Quadruplexes; Molecular Probe Techniques; Nucleic Acid Amplification Techniques; Reproducibility of Results; Sensitivity and Specificity; Staining and Labeling; Thiazoles | 2016 |
The dye SYPRO orange binds to amylin amyloid fibrils but not pre-fibrillar intermediates.
Topics: Amyloid; Benzothiazoles; Fluorescent Dyes; Humans; Islet Amyloid Polypeptide; Kinetics; Thiazoles | 2016 |
2A4 binds soluble and insoluble light chain aggregates from AL amyloidosis patients and promotes clearance of amyloid deposits by phagocytosis
Topics: Amyloidogenic Proteins; Amyloidosis; Animals; Antibodies, Monoclonal; Antigen-Antibody Complex; Benzothiazoles; Cell Line; Humans; Immunoglobulin Light Chains; Mice; Monocytes; Phagocytosis; Protein Aggregates; Protein Binding; Staining and Labeling; Thiazoles | 2016 |
Polyphenols from wolfberry and their bioactivities.
Topics: Acetylcholinesterase; Alzheimer Disease; Benzothiazoles; Biphenyl Compounds; Chlorogenic Acid; Cholinesterase Inhibitors; Flavonoids; Food Analysis; Free Radical Scavengers; Free Radicals; Lignans; Lycium; Molecular Structure; Oxygen; Picrates; Plant Extracts; Polyphenols; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Thiazoles | 2017 |
Detection of type I collagen fibrils formation and dissociation by a fluorescence method based on thioflavin T.
Topics: Animals; Benzothiazoles; Collagen Type I; Extracellular Matrix; Fluorescent Dyes; Kinetics; Pepsin A; Perciformes; Phase Transition; Protein Stability; Protein Structure, Secondary; Skin; Solubility; Solutions; Spectrometry, Fluorescence; Temperature; Thiazoles | 2016 |
Characterizing harmful advanced glycation end-products (AGEs) and ribosylated aggregates of yellow mustard seed phytocystatin: Effects of different monosaccharides.
Topics: Benzothiazoles; Circular Dichroism; Comet Assay; Congo Red; Cystatins; Glycation End Products, Advanced; Glycosylation; Monosaccharides; Mustard Plant; Nephelometry and Turbidimetry; Papain; Protein Aggregates; Protein Structure, Secondary; Protein Structure, Tertiary; Ribose; Seeds; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Thiazoles | 2017 |
Anti-amyloidogenic behavior and interaction of Diallylsulfide with Human Serum Albumin.
Topics: Allyl Compounds; Amyloid; Benzothiazoles; Binding Sites; Fluorescent Dyes; Humans; Kinetics; Molecular Docking Simulation; Protein Binding; Protein Structure, Secondary; Serum Albumin; Spectrometry, Fluorescence; Sulfides; Thermodynamics; Thiazoles | 2016 |
A Robust and Efficient Production and Purification Procedure of Recombinant Alzheimers Disease Methionine-Modified Amyloid-β Peptides.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Humans; Inclusion Bodies; Methionine; Peptide Fragments; Recombinant Proteins; Spectrophotometry, Ultraviolet; Staining and Labeling; Thiazoles | 2016 |
Rapid α-oligomer formation mediated by the Aβ C terminus initiates an amyloid assembly pathway.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Circular Dichroism; Fluorescent Dyes; Humans; Peptide Fragments; Peptides; Protein Aggregation, Pathological; Protein Engineering; Protein Multimerization; Protein Structure, Secondary; Spectrum Analysis; Thiazoles; Time Factors | 2016 |
Thioflavin T as a fluorescence light-up probe for both parallel and antiparallel G-quadruplexes of 29-mer thrombin binding aptamer.
Topics: Aptamers, Nucleotide; Benzothiazoles; Calorimetry; Fluorescent Dyes; G-Quadruplexes; Protein Binding; Spectrometry, Fluorescence; Thiazoles | 2016 |
Label-free fluorescence turn-on detection of uracil DNA glycosylase activity based on G-quadruplex formation.
Topics: Benzothiazoles; Fluorescence; Fluorescent Dyes; Fluorouracil; G-Quadruplexes; HeLa Cells; Humans; Thiazoles; Uracil-DNA Glycosidase | 2016 |
Highly Efficient Destruction of Amyloid-β Fibrils by Femtosecond Laser-Induced Nanoexplosion of Gold Nanorods.
Topics: Amyloid; Benzothiazoles; Cell Line, Tumor; Explosions; Gold; Humans; Laser Therapy; Lasers; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Nanotubes; Protein Structure, Secondary; Spectrum Analysis; Thiazoles | 2016 |
Regulation of osteoblast development by Bcl-2-associated athanogene-1 (BAG-1).
Topics: Animals; Apoptosis; Benzothiazoles; Bone Marrow Cells; Bone Morphogenetic Protein 2; Cell Differentiation; Cell Proliferation; Cell Survival; Cells, Cultured; DNA; DNA-Binding Proteins; Estrogens; Female; Gene Expression Regulation; Haploinsufficiency; Heterozygote; HSC70 Heat-Shock Proteins; Mice; Osteoblasts; Osteogenesis; Peptides; Receptors, Estrogen; Thiazoles; Transcription Factors | 2016 |
Appraisal of role of the polyanionic inducer length on amyloid formation by 412-residue 1N4R Tau protein: A comparative study.
Topics: Amyloid; Anions; Benzothiazoles; Circular Dichroism; DNA, Complementary; Enoxaparin; Glycosaminoglycans; Heparin; Humans; Kinetics; Microscopy, Atomic Force; Molecular Conformation; Molecular Weight; Protein Denaturation; Protein Folding; Protein Isoforms; Spectroscopy, Fourier Transform Infrared; tau Proteins; Thiazoles; Ultraviolet Rays; X-Ray Diffraction | 2016 |
Evaluation of an Ultrafast Molecular Rotor, Auramine O, as a Fluorescent Amyloid Marker.
Topics: Animals; Benzophenoneidum; Benzothiazoles; Binding Sites; Cattle; Circular Dichroism; Humans; Hydrophobic and Hydrophilic Interactions; Insulin; Molecular Docking Simulation; Protein Binding; Protein Structure, Tertiary; Serum Albumin, Bovine; Static Electricity; Temperature; Thermodynamics; Thiazoles | 2016 |
Fibrils of Truncated Pyroglutamyl-Modified Aβ Peptide Exhibit a Similar Structure as Wildtype Mature Aβ Fibrils.
Topics: Amyloid; Amyloid beta-Peptides; Benzothiazoles; Carbon-13 Magnetic Resonance Spectroscopy; Fluorescence; Pyrrolidonecarboxylic Acid; Thiazoles | 2016 |
Cerebrospinal fluid-induced retardation of amyloid β aggregation correlates with Alzheimer's disease and the APOE ε4 allele.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Apolipoprotein E4; Benzothiazoles; Case-Control Studies; Cerebrospinal Fluid; Cholesterol, HDL; Chromatography, Gel; Female; Heterozygote; Humans; Immunoblotting; Kinetics; Male; Middle Aged; Peptide Fragments; Prospective Studies; Protein Multimerization; Thiazoles | 2016 |
Amyloidogenesis of the amylin analogue pramlintide.
Topics: Amyloid; Benzothiazoles; Humans; Hydrogen-Ion Concentration; Hypoglycemic Agents; In Vitro Techniques; Islet Amyloid Polypeptide; Kinetics; Mass Spectrometry; Microscopy; Solubility; Thiazoles; X-Ray Diffraction | 2016 |
Thioflavin T behaves as an efficient fluorescent ligand for label-free ATP aptasensor.
Topics: Adenosine Triphosphate; Aptamers, Nucleotide; Benzothiazoles; Biosensing Techniques; Circular Dichroism; Fluorescent Dyes; Spectrometry, Fluorescence; Thiazoles | 2016 |
PicoGreen: a better amyloid probe than Thioflavin-T.
Topics: Amyloid; Benzothiazoles; Fluorescent Dyes; Humans; Insulin; Models, Molecular; Molecular Docking Simulation; Molecular Probes; Organic Chemicals; Protein Binding; Thiazoles | 2016 |
Benzothiazole-Based Neutral Ratiometric Fluorescence Sensor for Amyloid Fibrils.
Topics: Amyloid; Benzothiazoles; Blood-Brain Barrier; Fluorescent Dyes; Molecular Docking Simulation; Solvents; Thiazoles | 2016 |
Amyloid formation characteristics of GNNQQNY from yeast prion protein Sup35 and its seeding with heterogeneous polypeptides.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Insulin; Mice; Mice, Transgenic; Muramidase; Peptide Termination Factors; Prion Proteins; Protein Aggregates; Protein Aggregation, Pathological; Protein Conformation, beta-Strand; Protein Folding; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serum Albumin; Spectrometry, Fluorescence; Thiazoles | 2017 |
Polyols (Glycerol and Ethylene glycol) mediated amorphous aggregate inhibition and secondary structure restoration of metalloproteinase-conalbumin (ovotransferrin).
Topics: Benzothiazoles; Circular Dichroism; Conalbumin; Dynamic Light Scattering; Ethylene Glycol; Glycerol; Metalloproteases; Protein Aggregates; Protein Structure, Secondary; Thiazoles | 2017 |
Label-free monitoring of DNA polymerase activity based on a thrombin-binding aptamer G-quadruplex.
Topics: Aptamers, Nucleotide; Base Sequence; Benzothiazoles; DNA Polymerase I; DNA Probes; DNA-Directed DNA Polymerase; Fluorescence; G-Quadruplexes; Staining and Labeling; Thiazoles; Time Factors | 2017 |
Epigallocatechin Gallate Remodels Overexpressed Functional Amyloids in Pseudomonas aeruginosa and Increases Biofilm Susceptibility to Antibiotic Treatment.
Topics: Amyloid; Bacterial Proteins; Benzothiazoles; Biofilms; Catechin; Drug Resistance, Bacterial; Gene Expression Regulation, Bacterial; Humans; Pseudomonas aeruginosa; Pseudomonas Infections; Thiazoles; Tobramycin | 2016 |
Repositioning nordihydroguaiaretic acid as a potent inhibitor of systemic amyloidosis and associated cellular toxicity.
Topics: Amyloid; Amyloidosis; Benzothiazoles; Cell Line, Tumor; Hot Temperature; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Immunoglobulin Light-chain Amyloidosis; Inhibitory Concentration 50; Kinetics; Light; Masoprocol; Microscopy, Fluorescence; Molecular Docking Simulation; Muramidase; Nephelometry and Turbidimetry; Protein Aggregates; Protein Binding; Protein Conformation; Scattering, Radiation; Spectrometry, Fluorescence; Thiazoles | 2016 |
Citrullination and deamidation affect aggregation properties of amyloid β-proteins.
Topics: Amides; Amino Acid Sequence; Amyloid beta-Peptides; Benzothiazoles; Citrulline; Humans; Hydrogen-Ion Concentration; Molecular Dynamics Simulation; Peptide Fragments; Protein Aggregates; Protein Conformation, beta-Strand; Protein Processing, Post-Translational; Solubility; Static Electricity; Thiazoles | 2016 |
Simplified Murine 3D Neuronal Cultures for Investigating Neuronal Activity and Neurodegeneration.
Topics: Animals; Benzothiazoles; Calcium Signaling; Cell Culture Techniques; Cell Differentiation; Cell Survival; Cells, Cultured; Mice; Microscopy, Confocal; Models, Neurological; Nerve Tissue Proteins; Neural Stem Cells; Neurons; Prion Diseases; Spheroids, Cellular; Thiazoles | 2017 |
Examining the inhibitory potency of food additive fast green FCF against amyloid fibrillogenesis under acidic conditions.
Topics: Amyloid; Animals; Benzothiazoles; Chickens; Circular Dichroism; Egg White; Hydrogen-Ion Concentration; Lissamine Green Dyes; Muramidase; Thiazoles | 2016 |
Label/quencher-free detection of single-nucleotide changes in DNA using isothermal amplification and G-quadruplexes.
Topics: Benzothiazoles; Biosensing Techniques; DNA; ErbB Receptors; G-Quadruplexes; Humans; Nucleic Acid Amplification Techniques; Nucleotides; Polymorphism, Single Nucleotide; Spectrometry, Fluorescence; Thiazoles | 2016 |
Investigation of the relationship between the rodlet formation and Cys3-Cys4 loop of the HGFI hydrophobin.
Topics: Benzothiazoles; Circular Dichroism; Congo Red; Cysteine; Fungal Proteins; Hydrophobic and Hydrophilic Interactions; Microscopy, Atomic Force; Photoelectron Spectroscopy; Polystyrenes; Protein Domains; Protein Structure, Secondary; Recombinant Proteins; Surface Properties; Thiazoles; Trichoderma; Water | 2017 |
Interaction of nonionic detergents with the specific sites of lysozyme amyloidogenic region - inhibition of amyloid fibrillization.
Topics: Amyloid; Animals; Benzothiazoles; Binding Sites; Chickens; Circular Dichroism; Detergents; Dose-Response Relationship, Drug; Egg White; Glucosides; Humans; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Kinetics; Light; Micelles; Microscopy, Atomic Force; Models, Molecular; Muramidase; Octoxynol; Protein Conformation; Scattering, Radiation; Spectrophotometry, Ultraviolet; Surface Properties; Temperature; Thiazoles | 2017 |
Identification of Compounds that Selectively Stabilize Specific G-Quadruplex Structures by Using a Thioflavin T-Displacement Assay as a Tool.
Topics: Benzothiazoles; Fluorescence; G-Quadruplexes; High-Throughput Screening Assays; Ligands; Thiazoles | 2016 |
Characterization and analysis of binding of Thioflavin T with partially folded and native states of α-lactalbumin protein by calorimetric and spectroscopic techniques.
Topics: Animals; Benzothiazoles; Calorimetry; Cattle; Lactalbumin; Protein Binding; Protein Conformation; Protein Denaturation; Protein Folding; Spectrum Analysis; Thermodynamics; Thiazoles | 2017 |
Structural Rearrangement from Oligomer to Fibril Detected with FRET in a Designed Amphiphilic Peptide.
Topics: Amino Acid Sequence; Benzothiazoles; Circular Dichroism; Fluorescence Resonance Energy Transfer; Microscopy, Electron, Transmission; Molecular Sequence Data; Osmolar Concentration; Peptides; Protein Folding; Protein Structure, Secondary; Spectrophotometry, Infrared; Temperature; Thiazoles | 2017 |
Development of a novel catalytic amyloid displaying a metal-dependent ATPase-like activity.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphatases; Adenosine Triphosphate; Amyloid; Amyloidogenic Proteins; Benzothiazoles; Catalysis; Catalytic Domain; Computer Simulation; Humans; Hydrogen-Ion Concentration; Hydrolysis; Ions; Magnesium; Manganese; Metals; Peptides; Thiazoles | 2017 |
Dodecylphosphocholine Micelles Induce Amyloid Formation of the PrP(110-136) Peptide via an α-Helical Metastable Conformation.
Topics: Amyloid; Benzothiazoles; Birefringence; Humans; Magnetic Resonance Spectroscopy; Micelles; Microscopy; Phosphorylcholine; Prion Proteins; Protein Conformation, alpha-Helical; Thiazoles | 2016 |
On the Molecular Form of Amyloid Marker, Auramine O, in Human Insulin Fibrils.
Topics: Acrylic Resins; Amyloid; Artifacts; Benzophenoneidum; Benzothiazoles; Fluorescent Dyes; Humans; Insulins; Kinetics; Muramidase; Polymers; Protein Aggregates; Protons; Serum Albumin, Human; Sodium Dodecyl Sulfate; Staining and Labeling; Sulfonic Acids; Thiazoles | 2016 |
Detection and Quantification Methods for Fibrillar Products of In Vitro Tau Aggregation Assays.
Topics: Alzheimer Disease; Animals; Benzothiazoles; Biological Assay; Humans; Microscopy, Electron; Protein Aggregation, Pathological; tau Proteins; Thiazoles | 2017 |
Glycoprotein quality control-related proteins effectively inhibit fibrillation of amyloid beta 1-42.
Topics: Amyloid; Amyloid beta-Peptides; Benzothiazoles; Electrophoresis, Polyacrylamide Gel; Fluorescence; Glycoproteins; Humans; Protein Aggregates; Protein Denaturation; Solutions; Thiazoles | 2016 |
Deciphering the interaction of bovine heart cystatin with ZnO nanoparticles: Spectroscopic and thermodynamic approach.
Topics: Anilino Naphthalenesulfonates; Animals; Benzothiazoles; Buffaloes; Cystatins; Hydrophobic and Hydrophilic Interactions; Myocardium; Nanoparticles; Papain; Protein Binding; Protein Domains; Protein Structure, Secondary; Spectrometry, Fluorescence; Thermodynamics; Thiazoles; Zinc Oxide | 2017 |
Heparin and Methionine Oxidation Promote the Formation of Apolipoprotein A-I Amyloid Comprising α-Helical and β-Sheet Structures.
Topics: Amyloidogenic Proteins; Apolipoprotein A-I; Benzothiazoles; Cloning, Molecular; Escherichia coli; Gene Expression; Heparin; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Methionine; Oxidation-Reduction; Protein Aggregates; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Recombinant Proteins; Spectrometry, Fluorescence; Thiazoles | 2017 |
A Sensitive and Label-Free Pb(II) Fluorescence Sensor Based on a DNAzyme Controlled G-Quadruplex/Thioflavin T Conformation.
Topics: Benzothiazoles; Biosensing Techniques; DNA, Catalytic; Fluorescence; G-Quadruplexes; Lead; Limit of Detection; Molecular Conformation; Staining and Labeling; Temperature; Thiazoles | 2016 |
Tyrosine Hydroxylase Binding to Phospholipid Membranes Prompts Its Amyloid Aggregation and Compromises Bilayer Integrity.
Topics: Amyloid; Animals; Benzothiazoles; Catalytic Domain; Cell Membrane; Cell Survival; Circular Dichroism; Flow Cytometry; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Lipid Bilayers; Liposomes; Microscopy, Atomic Force; Microscopy, Confocal; Mitochondria; Molecular Conformation; PC12 Cells; Permeability; Phosphatidylcholines; Phospholipids; Rats; Subcellular Fractions; Thiazoles; Tyrosine 3-Monooxygenase | 2016 |
Analysis of sheep α-synuclein provides a molecular strategy for the reduction of fibrillation.
Topics: alpha-Synuclein; Amino Acid Sequence; Amyloid; Animals; Benzothiazoles; Humans; Hydrogen-Ion Concentration; Kinetics; Lewy Bodies; Mutation; Parkinson Disease; Protein Aggregation, Pathological; Sequence Alignment; Sheep; Solubility; Thiazoles | 2017 |
Self-assembly of aromatic α-amino acids into amyloid inspired nano/micro scaled architects.
Topics: Amino Acids, Aromatic; Amyloid; Benzothiazoles; Congo Red; Magnetic Resonance Spectroscopy; Microscopy, Atomic Force; Microscopy, Confocal; Nanostructures; Spectroscopy, Fourier Transform Infrared; Thermogravimetry; Thiazoles; Water; X-Ray Diffraction | 2017 |
Quantitative Comparison of Dense-Core Amyloid Plaque Accumulation in Amyloid-β Protein Precursor Transgenic Mice.
Topics: Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Cerebral Cortex; Disease Models, Animal; Female; Hippocampus; Humans; Male; Mice, Transgenic; Plaque, Amyloid; Species Specificity; Thiazoles | 2017 |
G-quadruplex-based fluorometric biosensor for label-free and homogenous detection of protein acetylation-related enzymes activities.
Topics: Acetylation; Benzothiazoles; Biosensing Techniques; Drug Evaluation, Preclinical; Enzyme Assays; Fluorescent Dyes; G-Quadruplexes; HeLa Cells; Histone Acetyltransferases; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Limit of Detection; Peptides; Spectrometry, Fluorescence; Thiazoles | 2017 |
Propagation of pathological α-synuclein in marmoset brain.
Topics: alpha-Synuclein; Animals; Benzothiazoles; Brain; Callithrix; Female; Immunohistochemistry; Lewy Bodies; Microglia; Nerve Degeneration; Neurons; Parkinsonian Disorders; Protein Aggregation, Pathological; Recombinant Proteins; Sequence Homology, Amino Acid; Thiazoles; Tyrosine 3-Monooxygenase | 2017 |
Label-free fluorescent assay of T4 polynucleotide kinase phosphatase activity based on G-quadruplexe-thioflavin T complex.
Topics: Benzothiazoles; Biological Assay; DNA; DNA Repair Enzymes; Fluorescence; Fluorescent Dyes; G-Quadruplexes; Humans; Limit of Detection; Phosphotransferases (Alcohol Group Acceptor); Thiazoles | 2017 |
Amyloidogenicity and toxicity of the reverse and scrambled variants of amyloid-β 1-42.
Topics: Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Amyloidogenic Proteins; Animals; Animals, Newborn; Benzothiazoles; Cell Survival; Hippocampus; Humans; Neurons; Peptide Fragments; Primary Cell Culture; Protein Conformation, beta-Strand; Rats; Spectrometry, Fluorescence; Thiazoles | 2017 |
Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects.
Topics: Animals; Benzothiazoles; Caenorhabditis; Caenorhabditis elegans; Dose-Response Relationship, Drug; Fertility; Genetic Background; Longevity; Organic Chemicals; Reproducibility of Results; Species Specificity; Thiazoles | 2017 |
Aloe emodin, an anthroquinone from Aloe vera acts as an anti aggregatory agent to the thermally aggregated hemoglobin.
Topics: Aloe; Anilino Naphthalenesulfonates; Animals; Anthraquinones; Benzothiazoles; Cattle; Circular Dichroism; Congo Red; Hemoglobins; Nephelometry and Turbidimetry; Protein Aggregates; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Temperature; Thiazoles | 2017 |
Analysis of the potency of various low molecular weight chemical chaperones to prevent protein aggregation.
Topics: Benzothiazoles; Cell Line; Docosahexaenoic Acids; Endoplasmic Reticulum Stress; Epithelial Cells; Glycerol; Humans; Kidney Tubules, Proximal; Molecular Weight; Phenylbutyrates; Protein Aggregates; Protein Aggregation, Pathological; Protein Folding; Staining and Labeling; Taurochenodeoxycholic Acid; Thapsigargin; Thiazoles; Trehalose; Unfolded Protein Response; Xenobiotics | 2017 |
Distinct Mechanisms Determine α-Synuclein Fibril Morphology during Growth and Maturation.
Topics: alpha-Synuclein; Benzothiazoles; Circular Dichroism; Humans; Microscopy, Atomic Force; Multiprotein Complexes; Mutation; Protein Aggregation, Pathological; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiazoles; Time Factors | 2017 |
Label-free and rapid detection of ATP based on structure switching of aptamers.
Topics: A549 Cells; Adenosine Triphosphate; Aptamers, Nucleotide; Benzothiazoles; Biosensing Techniques; Fluorescence; Fluorescent Dyes; HeLa Cells; Humans; Limit of Detection; Serum; Thiazoles | 2017 |
Combined thioflavin T-Congo red fluorescence assay for amyloid fibril detection.
Topics: Amyloid; Benzothiazoles; Congo Red; Fluorescence; Fluorescent Dyes; Kinetics; Protein Binding; Reproducibility of Results; Thiazoles | 2016 |
Binding of Thioflavin-T to Amyloid Fibrils Leads to Fluorescence Self-Quenching and Fibril Compaction.
Topics: Amyloid; Benzothiazoles; Fluorescent Dyes; Protein Binding; Protein Folding; Spectrometry, Fluorescence; Thiazoles | 2017 |
Fibrillar disruption by AC electric field induced oscillation: A case study with human serum albumin.
Topics: Benzothiazoles; Circular Dichroism; Electricity; Humans; Microscopy, Electron, Transmission; Protein Structure, Secondary; Serum Albumin; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2017 |
Pyroglutamate-Modified Amyloid-β(3-42) Shows α-Helical Intermediates before Amyloid Formation.
Topics: Amyloid; Amyloid beta-Peptides; Animals; Benzothiazoles; Circular Dichroism; Kinetics; Microscopy, Electron, Transmission; Nuclear Magnetic Resonance, Biomolecular; Peptide Fragments; Protein Aggregation, Pathological; Protein Structure, Secondary; Recombinant Proteins; Solutions; Thiazoles; Trifluoroethanol; Water | 2017 |
Concentration dependent switch in the kinetic pathway of lysozyme fibrillation: Spectroscopic and microscopic analysis.
Topics: Amyloid; Benzothiazoles; Hydrogen-Ion Concentration; Kinetics; Microscopy; Muramidase; Polymerization; Protein Conformation; Spectrometry, Fluorescence; Thiazoles; Urea | 2017 |
Amyloid-like Fibrils from an α-Helical Transmembrane Protein.
Topics: Amyloid; Benzothiazoles; Circular Dichroism; Escherichia coli; Escherichia coli Proteins; Humans; Microscopy, Electron, Transmission; Monosaccharide Transport Proteins; Protein Conformation, alpha-Helical; Spectroscopy, Fourier Transform Infrared; Symporters; Thiazoles; X-Ray Diffraction | 2017 |
Kinetic Mechanism of Thioflavin T Binding onto the Amyloid Fibril of Hen Egg White Lysozyme.
Topics: Amyloid; Animals; Benzothiazoles; Chickens; Egg White; Kinetics; Muramidase; Protein Binding; Thiazoles | 2017 |
Aromatic-interaction-mediated inhibition of β-amyloid assembly structures and cytotoxicity.
Topics: Amyloid beta-Peptides; Benzothiazoles; Circular Dichroism; Humans; Microscopy, Atomic Force; Molecular Docking Simulation; Peptide Fragments; Peptides; Thiazoles | 2017 |
Structure-activity relationships for flavone interactions with amyloid β reveal a novel anti-aggregatory and neuroprotective effect of 2',3',4'-trihydroxyflavone (2-D08).
Topics: Amyloid beta-Peptides; Animals; Benzothiazoles; Binding Sites; Cell Survival; Flavones; Flavonoids; Humans; Hydrogen Bonding; Microscopy, Electron, Transmission; Molecular Docking Simulation; Neuroprotective Agents; PC12 Cells; Peptide Fragments; Protein Binding; Protein Structure, Tertiary; Rats; Structure-Activity Relationship; Thiazoles | 2017 |
Thioflavin T fluorescence to analyse amyloid formation kinetics: Measurement frequency as a factor explaining irreproducibility.
Topics: Amyloid; Amyloidosis; Anilino Naphthalenesulfonates; Benzothiazoles; Fluorescence; Fluorescent Dyes; Humans; Islet Amyloid Polypeptide; Kinetics; Microscopy, Electron, Transmission; Reproducibility of Results; Spectrometry, Fluorescence; Thiazoles; Uncertainty | 2017 |
Detection and Characterization of Small Molecule Interactions with Fibrillar Protein Aggregates Using Microscale Thermophoresis.
Topics: alpha-Synuclein; Benzothiazoles; Binding, Competitive; Dose-Response Relationship, Drug; Drug Discovery; Humans; Indoles; Microscopy, Atomic Force; Optical Imaging; Protective Agents; Protein Aggregation, Pathological; Protein Binding; tau Proteins; Thermal Diffusion; Thiazoles | 2017 |
Role of Site-Specific Asparagine Deamidation in Islet Amyloid Polypeptide Amyloidogenesis: Key Contributions of Residues 14 and 21.
Topics: Amino Acid Substitution; Animals; Asparagine; Benzothiazoles; Cell Line, Tumor; Insulin-Secreting Cells; Islet Amyloid Polypeptide; Mutation, Missense; Protein Aggregates; Protein Aggregation, Pathological; Rats; Thiazoles | 2017 |
Enzymatic O-GlcNAcylation of α-synuclein reduces aggregation and increases SDS-resistant soluble oligomers.
Topics: alpha-Synuclein; Benzothiazoles; Humans; N-Acetylglucosaminyltransferases; Protein Aggregates; Protein Multimerization; Protein Processing, Post-Translational; Sodium Dodecyl Sulfate; Solubility; Thiazoles | 2017 |
Bexarotene Does Not Clear Amyloid Beta Plaques but Delays Fibril Growth: Molecular Mechanisms.
Topics: Amyloid beta-Peptides; Benzothiazoles; Bexarotene; Dose-Response Relationship, Drug; Humans; Kinetics; Microscopy, Atomic Force; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Neuroprotective Agents; Plaque, Amyloid; Protein Multimerization; Protein Structure, Secondary; Tetrahydronaphthalenes; Thiazoles; Water | 2017 |
A molecular rotor based ratiometric sensor for basic amino acids.
Topics: Amino Acids, Basic; Animals; Benzothiazoles; Circular Dichroism; Heparin; Spectrometry, Fluorescence; Spectrum Analysis; Sus scrofa; Thiazoles | 2018 |
Microvascular ultrastructural changes precede cognitive impairment in the murine APPswe/PS1dE9 model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Benzothiazoles; Capillaries; Cerebral Cortex; Cognitive Dysfunction; Disease Models, Animal; Exploratory Behavior; Intussusception; Kidney Glomerulus; Liver; Male; Memory, Short-Term; Mice, Transgenic; Microvessels; Plaque, Amyloid; Spleen; Thiazoles | 2017 |
Microchip Circulation Drastically Accelerates Amyloid Aggregation of 1-42 β-amyloid Peptide from Felis catus.
Topics: Amyloid; Amyloid beta-Peptides; Animals; Benzothiazoles; Cats; Circular Dichroism; Drug Evaluation, Preclinical; Fluorometry; Lab-On-A-Chip Devices; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Peptide Fragments; Protein Aggregates; Protein Aggregation, Pathological; Protein Folding; Rheology; Scattering, Small Angle; Shear Strength; Surface-Active Agents; Thiazoles; X-Ray Diffraction | 2017 |
Modulation of the extent of structural heterogeneity in α-synuclein fibrils by the small molecule thioflavin T.
Topics: alpha-Synuclein; Benzothiazoles; Humans; Multiprotein Complexes; Protein Aggregation, Pathological; Protein Multimerization; Thiazoles | 2017 |
Elucidation of insulin assembly at acidic and neutral pH: Characterization of low molecular weight oligomers.
Topics: Amyloid; Benzothiazoles; Circular Dichroism; Humans; Hydrogen-Ion Concentration; Insulin; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Molecular Weight; Protein Aggregates; Thiazoles | 2017 |
Correlation of cholinergic drug induced quenching of acetylcholinesterase bound thioflavin-T fluorescence with their inhibition activity.
Topics: Acetylcholinesterase; Benzothiazoles; Cholinesterase Inhibitors; Fluorescence; Hydrogen Bonding; Hydrolysis; Kinetics; Molecular Docking Simulation; Spectrometry, Fluorescence; Thermodynamics; Thiazoles | 2018 |
Deciphering the enhanced inhibitory, disaggregating and cytoprotective potential of promethazine towards amyloid fibrillation.
Topics: Amyloid; Amyloidogenic Proteins; Amyloidosis; Anilino Naphthalenesulfonates; Benzothiazoles; Circular Dichroism; Dynamic Light Scattering; Fluorescence; Humans; Insulin; Muramidase; Parkinson Disease; Promethazine; Protein Aggregates; Protein Aggregation, Pathological; Thiazoles | 2018 |
Graphene oxide-iron oxide nanocomposite as an inhibitor of Aβ 42 amyloid peptide aggregation.
Topics: Amyloid; Amyloid beta-Peptides; Benzothiazoles; Cell Line, Tumor; Circular Dichroism; Ferric Compounds; Graphite; Humans; Microscopy, Electron, Transmission; Nanocomposites; Oxides; Peptide Fragments; Thiazoles | 2017 |
Binding of Thioflavin T and Related Probes to Polymorphic Models of Amyloid-β Fibrils.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Binding Sites; Fluorescent Dyes; Humans; Models, Molecular; Peptide Fragments; Protein Binding; Protein Conformation, beta-Strand; Thermodynamics; Thiazoles | 2017 |
RT-QuIC Assays for Prion Disease Detection and Diagnostics.
Topics: Amyloid; Animals; Benzothiazoles; Biological Assay; Brain; Brain Chemistry; Fluorescent Dyes; Gene Expression; Humans; Nasal Cavity; Prion Diseases; Protein Conformation, beta-Strand; Protein Folding; PrPC Proteins; PrPSc Proteins; Recombinant Proteins; Sensitivity and Specificity; Thiazoles | 2017 |
Amyloid fibril aggregation: An insight into the underwater adhesion of barnacle cement.
Topics: Adhesiveness; Adhesives; Amyloid; Animals; Arthropod Proteins; Benzothiazoles; Protein Binding; Thiazoles; Thoracica | 2017 |
Aqueous RAFT Synthesis of Glycopolymers for Determination of Saccharide Structure and Concentration Effects on Amyloid β Aggregation.
Topics: Acrylamide; Amyloid beta-Peptides; Benzothiazoles; Biomimetic Materials; G(M1) Ganglioside; Galactose; Glucose; Polymerization; Protein Aggregates; Thiazoles | 2017 |
Acetylation of lysine residues in apomyoglobin: Structural changes, amyloid fibrillation, and role of surface charge.
Topics: Acetylation; Amyloidogenic Proteins; Animals; Apoproteins; Benzothiazoles; Cell Survival; Heme; Horses; Lysine; Myoglobin; PC12 Cells; Protein Aggregates; Protein Processing, Post-Translational; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Spectrometry, Fluorescence; Static Electricity; Thiazoles | 2018 |
Soluble polymorphic bank vole prion proteins induced by co-expression of quiescin sulfhydryl oxidase in E. coli and their aggregation behaviors.
Topics: Animals; Arvicolinae; Benzothiazoles; Circular Dichroism; Escherichia coli; Humans; Mice; Mice, Transgenic; Microscopy, Electron; Oxidoreductases; Polymorphism, Genetic; Prion Diseases; Prion Proteins; Prions; Protein Aggregates; PrPC Proteins; Surface Plasmon Resonance; Thiazoles | 2017 |
Thioflavin T binds dimeric parallel-stranded GA-containing non-G-quadruplex DNAs: a general approach to lighting up double-stranded scaffolds.
Topics: Adenine; Benzothiazoles; Biosensing Techniques; Dimerization; DNA; Fluorescent Dyes; G-Quadruplexes; Guanine; Hydrogen-Ion Concentration; Metals; Thiazoles | 2017 |
Influence of the ionic liquid 1-butyl-3-methylimidazolium bromide on amyloid fibrillogenesis in lysozyme: Evidence from photophysical and imaging studies.
Topics: Amyloid; Anilino Naphthalenesulfonates; Animals; Benzothiazoles; Chickens; Circular Dichroism; Congo Red; Imaging, Three-Dimensional; Imidazoles; Ionic Liquids; Light; Microscopy, Atomic Force; Muramidase; Oxazines; Spectrometry, Fluorescence; Thiazoles | 2018 |
Lysophosphatidylcholine modulates the aggregation of human islet amyloid polypeptide.
Topics: alpha-Synuclein; Benzothiazoles; Diabetes Mellitus, Type 2; Humans; Insulin-Secreting Cells; Islet Amyloid Polypeptide; Kinetics; Lysophosphatidylcholines; Microscopy, Electron, Transmission; Molecular Dynamics Simulation; Thiazoles | 2017 |
Real-Time Observation of the Interaction between Thioflavin T and an Amyloid Protein by Using High-Sensitivity Rheo-NMR.
Topics: Amyloid; Amyloidogenic Proteins; Benzothiazoles; Magnetic Resonance Spectroscopy; Protein Binding; Superoxide Dismutase-1; Thiazoles | 2017 |
Spontaneous Lipid Nanodisc Fomation by Amphiphilic Polymethacrylate Copolymers.
Topics: Benzothiazoles; Circular Dichroism; Fluorescence; Humans; Islet Amyloid Polypeptide; Lipid Bilayers; Membrane Proteins; Nanostructures; Polymethacrylic Acids; Thiazoles | 2017 |
Probing the inhibitory potency of epigallocatechin gallate against human γB-crystallin aggregation: Spectroscopic, microscopic and simulation studies.
Topics: Amino Acid Motifs; Amino Acids; Benzothiazoles; Catechin; Circular Dichroism; Computer Simulation; gamma-Crystallins; Humans; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kinetics; Nephelometry and Turbidimetry; Protein Aggregates; Protein Structure, Tertiary; Solutions; Spectrometry, Fluorescence; Thiazoles | 2018 |
Morphological Effects of CuO Nanostructures on Fibrillation of Human Serum Albumin.
Topics: Adsorption; Benzothiazoles; Copper; Fluorescent Dyes; Humans; Microscopy, Fluorescence; Nanostructures; Particle Size; Serum Albumin, Human; Surface Properties; Thiazoles | 2017 |
Binding of thioflavin T by albumins: An underestimated role of protein oligomeric heterogeneity.
Topics: Benzothiazoles; Binding Sites; Chromatography, Gel; Humans; Models, Molecular; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Binding; Protein Conformation; Protein Multimerization; Serum Albumin; Spectrometry, Fluorescence; Structure-Activity Relationship; Thiazoles | 2018 |
Light-triggered dissociation of self-assembled β-amyloid aggregates into small, nontoxic fragments by ruthenium (II) complex.
Topics: Amyloid beta-Peptides; Animals; Benzothiazoles; Circular Dichroism; Fluorescence; Humans; Light; Microscopy, Atomic Force; Oxidation-Reduction; PC12 Cells; Protein Aggregates; Protein Structure, Secondary; Rats; Ruthenium; Singlet Oxygen; Solubility; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiazoles | 2018 |
Amplified Fluorescent Detection of Mercuric Ions by Conjugation of the ThT-induced G-Quadruplex Based Hybridization Chain Reaction.
Topics: Benzothiazoles; G-Quadruplexes; Limit of Detection; Mercury; Nucleic Acid Hybridization; Spectrometry, Fluorescence; Thiazoles | 2017 |
NFGAIL Amyloid Oligomers: The Onset of Beta-Sheet Formation and the Mechanism for Fibril Formation.
Topics: Amyloid; Benzothiazoles; Humans; Mass Spectrometry; Microscopy, Electron, Transmission; Oligopeptides; Protein Structure, Secondary; Spectrophotometry, Infrared; Thiazoles | 2018 |
Amplified detection of genome-containing biological targets using terminal deoxynucleotidyl transferase-assisted rolling circle amplification.
Topics: Benzothiazoles; Biosensing Techniques; DNA; DNA Nucleotidylexotransferase; DNA-Directed DNA Polymerase; Fluorescent Dyes; Genome; Nucleic Acid Amplification Techniques; Thiazoles | 2018 |
Integrating DNA structure switch with branched hairpins for the detection of uracil-DNA glycosylase activity and inhibitor screening.
Topics: Base Pairing; Benzothiazoles; DNA; Enzyme Inhibitors; Fluorescent Dyes; G-Quadruplexes; HeLa Cells; High-Throughput Screening Assays; Humans; Inverted Repeat Sequences; Limit of Detection; MCF-7 Cells; Oligonucleotides; Spectrometry, Fluorescence; Thiazoles; Uracil-DNA Glycosidase | 2018 |
Direct visualization of nucleolar G-quadruplexes in live cells by using a fluorescent light-up probe.
Topics: Benzothiazoles; Cell Nucleus; Circular Dichroism; Fluorescent Dyes; G-Quadruplexes; Humans; MCF-7 Cells; Microscopy, Fluorescence; Molecular Probes; Spectrometry, Fluorescence; Thiazoles | 2018 |
E22G Pathogenic Mutation of β-Amyloid (Aβ) Enhances Misfolding of Aβ40 by Unexpected Prion-like Cross Talk between Aβ42 and Aβ40.
Topics: Amyloid beta-Peptides; Benzothiazoles; Fluorescent Dyes; Mutation; Peptide Fragments; Prions; Protein Folding; Thiazoles | 2018 |
Investigation of amyloid formation inhibition of chemically and biogenically from Citrus aurantium L. blossoms and Rose damascena oils of gold nanoparticles: Toxicity evaluation in rat pheochromocytoma PC12 cells.
Topics: Adrenal Gland Neoplasms; Amyloid; Animals; Benzothiazoles; Cell Survival; Citrus; Congo Red; Fluorescence; Gold; Humans; Metal Nanoparticles; PC12 Cells; Pheochromocytoma; Plant Oils; Rats; Rosa; Spectrophotometry, Ultraviolet; Thiazoles; Toxicity Tests | 2018 |
A Thioflavin T-induced G-Quadruplex Fluorescent Biosensor for Target DNA Detection.
Topics: Benzothiazoles; Biosensing Techniques; DNA; G-Quadruplexes; HIV; Spectrometry, Fluorescence; Thiazoles | 2018 |
Inhibition of amyloid fibrillation of lysozyme by bisdemethoxycurcumin and diacetylbisdemethoxycurcumin.
Topics: Amyloid; Animals; Benzothiazoles; Chickens; Curcumin; Diarylheptanoids; Molecular Docking Simulation; Molecular Structure; Muramidase; Particle Size; Protein Aggregates; Thiazoles | 2018 |
Search for Fibrous Aggregates Potentially Useful in Regenerative Medicine Formed under Physiological Conditions by Self-Assembling Short Peptides Containing Two Identical Aromatic Amino Acid Residues.
Topics: Amino Acids; Animals; Benzothiazoles; Cell Line; Cell Line, Tumor; Cell Survival; Congo Red; Dipeptides; Fibroblasts; Mice; Oligopeptides; Protein Aggregates; Regenerative Medicine; Thiazoles; Tissue Engineering; Tissue Scaffolds | 2018 |
Label-free and nicking enzyme-assisted fluorescence signal amplification for RNase H determination based on a G-quadruplexe/thioflavin T complex.
Topics: Benzothiazoles; Biological Assay; Deoxyribonucleases, Type II Site-Specific; DNA, Single-Stranded; Fluorescence; Fluorescent Dyes; G-Quadruplexes; Gentamicins; Humans; Inverted Repeat Sequences; Limit of Detection; Oligonucleotides; Protein Synthesis Inhibitors; Ribonuclease H; RNA; Spectrometry, Fluorescence; Thiazoles | 2018 |
Visible light-induced insulin aggregation on surfaces via photoexcitation of bound thioflavin T.
Topics: Benzothiazoles; Hydrophobic and Hydrophilic Interactions; Insulin; Light; Microscopy, Confocal; Microscopy, Electron, Scanning; Polystyrenes; Protein Aggregates; Protein Binding; Surface Properties; Thiazoles | 2018 |
1,2,4-trihydroxynaphthalene-2-O-β-D-glucopyranoside delays amyloid-β
Topics: Amyloid beta-Peptides; Benzothiazoles; Calcium; Cell Line, Tumor; Cell Survival; Circular Dichroism; Glucosides; Humans; Lawsonia Plant; Naphthalenes; Neurons; Neuroprotective Agents; Peptide Fragments; Plant Extracts; Protein Aggregates; Protein Conformation, beta-Strand; Reactive Oxygen Species; Spectrometry, Fluorescence; Thiazoles | 2018 |
Iron Redox Chemistry Promotes Antiparallel Oligomerization of α-Synuclein.
Topics: alpha-Synuclein; Benzothiazoles; Ferrous Compounds; Fluorescent Dyes; Humans; Oxidation-Reduction; Parkinson Disease; Thiazoles | 2018 |
Amyloid-like staining property of RADA16-I nanofibers and its potential application in detecting and imaging the nanomaterial.
Topics: Amyloid; Animals; Benzothiazoles; Coloring Agents; Congo Red; Doxorubicin; Drug Delivery Systems; Hydrogels; Male; Microscopy, Fluorescence; Molecular Imaging; Nanofibers; PC12 Cells; Peptides; Pyrenes; Rats; Rats, Sprague-Dawley; Spectrometry, Fluorescence; Staining and Labeling; Thiazoles | 2018 |
Aggregation kinetics of the Aβ1-40 peptide monitored by NMR.
Topics: Amyloid beta-Peptides; Benzothiazoles; Fluorescence; Kinetics; Magnetic Resonance Spectroscopy; Models, Chemical; Particle Size; Peptide Fragments; Protein Multimerization; Thiazoles | 2018 |
Study on the kinetic self-assembly of type I collagen from tilapia (Oreochromis niloticus) skin using the fluorescence probe thioflavin T.
Topics: Animals; Benzothiazoles; Collagen Type I; Fluorescent Dyes; Hydrogen-Ion Concentration; Kinetics; Osmolar Concentration; Pepsin A; Skin; Solubility; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Thiazoles; Tilapia | 2018 |
Rhenium Complexes of Bis(benzothiazole)-Based Tetraarylethylenes as Selective Luminescent Probes for Amyloid Fibrils.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Chelating Agents; Humans; Ligands; Luminescence; Peptide Fragments; Rhenium; Thiazoles | 2018 |
Physico-chemical properties of co-formulated fast-acting insulin with pramlintide.
Topics: Benzothiazoles; Diabetes Mellitus; Drug Combinations; Drug Compounding; Drug Stability; Humans; Hypoglycemic Agents; Insulin Aspart; Insulin Lispro; Islet Amyloid Polypeptide; Microscopy, Electron, Transmission; Protein Aggregation, Pathological; Spectrometry, Mass, Electrospray Ionization; Thiazoles | 2018 |