thioctic acid has been researched along with lipoamide in 73 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (21.92) | 18.7374 |
| 1990's | 19 (26.03) | 18.2507 |
| 2000's | 20 (27.40) | 29.6817 |
| 2010's | 16 (21.92) | 24.3611 |
| 2020's | 2 (2.74) | 2.80 |
| Authors | Studies |
|---|---|
| Brownlee, JM; Carlson, E; Harrison, DH; Milne, AC; Pape, E | 1 |
| Silver, M | 1 |
| Kelly, DP; Silver, M | 1 |
| Kropachova, K; Mishurova, E | 1 |
| Miura, T; Muraoka, S; Ogiso, T | 1 |
| Akiyama, K; Kamata, K | 1 |
| Bassendine, MF; Fussey, SP; James, OF; Yeaman, SJ | 1 |
| Baum, H; Brumfitt, W; Burroughs, AK; Butler, P; Chelliah, J; Flannery, GR; Hamilton-Miller, J | 1 |
| Hayakawa, K; Oizumi, J | 1 |
| Borisenko, GV; Khvisiuk, SS; Khvorostinka, VN; Kosenko, NP; Teslenko, VG | 1 |
| Verich, GE | 1 |
| Richarme, G | 1 |
| Huang, RR; Spector, A; Wang, RR; Yan, GZ | 1 |
| Ahmad, T; Frischer, H | 1 |
| Goji, K; Kodama, S; Matsuo, T; Morishita, Y; Ninomiya, M; Takahashi, T; Yagi, R | 1 |
| Cronshaw, AD; Jocelyn, PC | 1 |
| Ahmad, R; Armstrong, DA | 1 |
| Tsai, CS | 1 |
| Itow, T | 1 |
| Goldstein, BN; Saifullin, SR; Zakrzhevskaya, DT | 1 |
| Butwell, NB; Malloy, CR; Sherry, AD; Sumegi, B | 1 |
| Guest, JR; Maeda-Yorita, K; Massey, V; Russell, GC; Williams, CH | 1 |
| Janssen, YP; Thijssen, HH; Vervoort, LT | 1 |
| Hol, WG; Kalk, KH; Mattevi, A; Obmolova, G; van Berkel, WJ | 1 |
| Arnér, ES; Holmgren, A; Nordberg, J | 1 |
| Díaz, LE; Giorgieri, SA; Pañak, KC; Ruiz, OA | 1 |
| Boveris, A; Bustamante, J; Montero, G; Tovar-B, A | 1 |
| Han, D; Packer, L; Roy, S; Sen, CK | 1 |
| Bisby, RH; Parker, AW | 1 |
| Anusevicius, Z; Cènas, N; Didziapetrienè, J; Kersienè, R; Kliukienè, R; Marozienè, A | 1 |
| Beekman, NJ; Meloen, RH; Schaaper, WM; Turkstra, JA | 1 |
| Blackledge, M; Bourguignon, J; Douce, R; Gans, P; Guilhaudis, L; Marion, D; Neuburger, M; Simorre, JP | 1 |
| Field, MJ; Hinsen, K; Roche, O | 1 |
| Aevarsson, A; Hol, WG; Seger, K; Sokatch, JR; Turley, S | 1 |
| Fischer, GM; Gallyas, F; Kispal, G; Sumegi, B; Szabados, E | 1 |
| Bourguignon, J; Douce, R; Faure, M; Jourdain, A; Neuburger, M; Piètre, E; Polidori, AM; Pucci, B | 1 |
| Cabiscol, E; Echave, P; Herrero, E; Piulats, E; Ros, J | 1 |
| Self, WT; Stadtman, TC; Tsai, L | 1 |
| Andersson, LA; Baker, JC; Cole, AB; Gong, X; Li, L; Liu, S; Peng, T; Ravindran, S; Robben, PM; Roche, TE; Yan, X | 1 |
| Field, MJ; Roche, O | 1 |
| Brunk, UT; Persson, HL; Svensson, AI | 1 |
| Bryk, R; Erdjument-Bromage, H; Lima, CD; Nathan, C; Tempst, P | 1 |
| Argyrou, A; Blanchard, JS; Palfey, BA | 1 |
| Arjunan, P; Brunskill, A; Furey, W; Jordan, F; Nemeria, N; Sheibani, F; Wei, W; Yan, Y; Zhang, S | 1 |
| Argyrou, A; Blanchard, JS; Palfey, BA; Sun, G | 1 |
| Brunk, UT; Eaton, JW; Persson, HL; Tirosh, O; Yu, Z | 1 |
| INAMORI, K; SHIGETA, Y; WADA, M | 1 |
| Bourdette, DN; Marquardt, WE; Marracci, GH; McKeon, GP; Riscoe, MK; Winter, RW | 1 |
| Jordan, F; Nemeria, N; Park, YH; Wei, W; Zhou, L | 1 |
| Kamiya, N; Kuramitsu, S; Maoka, N; Masui, R; Nakagawa, N; Nakai, T | 1 |
| May, JM; Nelson, DJ; Qu, ZC | 1 |
| Daldal, F; Dancis, A; Hippler, M; Naumann, B; Onder, O; Yoon, H | 1 |
| Klyuyeva, A; Popov, KM; Tuganova, A | 1 |
| Bielarczyk, H; Gul-Hinc, S; Pawełczyk, T; Ronowska, A; Szutowicz, A | 1 |
| Cotman, CW; Hou, B; Jia, H; Li, X; Liu, J; Liu, Z; Luo, C; Packer, L; Shen, W; Sun, L | 1 |
| Arango, N; Bryk, R; Lima, CD; Nathan, C; Park, YH; Patel, MS; Venugopal, A; Warren, JD | 1 |
| Albers, WM; Laaksonen, P; Munter, T; Vikholm-Lundin, I | 1 |
| Bourdette, DN; Carr, DW; Regan, JW; Salinthone, S; Schillace, RV; Tsang, C | 1 |
| Chen, W; Feng, Z; Hao, J; Liu, J; Packer, L; Shen, W; Shi, X; Tian, C; Zang, W | 1 |
| Arnér, ES; Berners-Price, SJ; Callus, BA; Cheng, Q; Davies, SM; Filipovska, A; McNamara, E; Miranda-Vizuete, A; Rackham, O; Shearwood, AM; Thyer, R | 1 |
| Guo, X; Han, Z; Lai, PY; Li, Y; Lin, W; Liu, L; Qian, PY; Xu, Y; Zhang, X | 1 |
| Cormier, PJ; Kinter, M; McLain, AL; Szweda, LI | 1 |
| Hou, X; Huang, W; Li, Y; Luo, L; Miao, Z; Qi, Q; Shen, Y; Wang, F; Wang, H; Wang, L; Wang, Y; Wang, Z; Yang, S; Zhang, Y | 1 |
| Arango, N; Balakrishnan, A; Bryk, R; Hipskind, P; Lima, CD; Maksymiuk, C; Masquelin, T; Nathan, C; Wong, CH; Wu, YT | 1 |
| Budayeva, HG; Chakrabarti, R; Cristea, IM; Greco, TM; Kang, Y; Mathias, RA; Oberstein, A; Rowland, EA; Shenk, T | 1 |
| Feng, Z; Jia, H; Li, X; Liu, J; Liu, Z; Zhao, L | 1 |
| Bhatt, S; Boyd, JM; Carroll, RK; Mashruwala, AA; May, KL; Roberts, CA; Shaw, LN | 1 |
| Bai, Z; Guo, S; Qu, Y; Shu, M; Zhang, Y; Zhou, R | 1 |
| Crulli, M; Gallo, A; Lapolla, A; Nuti, F; Papini, AM; Peroni, E; Piarulli, F; Real-Fernandez, F; Rentier, C; Rossi, G; Rovero, P; Traldi, P | 1 |
| Guo, B; Jiang, X; Mao, Y; Peng, C; Tang, L; Wang Wang, Y; Xiao, Y; Yuan, Z; Zhang, F; Zhang, Y | 1 |
| Bai, F; Fang, J; Hou, Y; Li, X; Peng, S; Yao, J | 1 |
| Chatterji, A; Sachin, K; Sengupta, R | 1 |
| Chen, RY; Guo, B; Liang, LQ; Liu, HM; Liu, LL; Shi, MJ; Tan, WL; Tang, L; Wang, D; Wang, YY; Xiang, JY; Xiao, Y; Zhang, F; Zhang, HF; Zhang, T; Zhou, XC; Zhou, YX | 1 |
73 other study(ies) available for thioctic acid and lipoamide
| Article | Year |
|---|---|
Structural and thermodynamic studies of simple aldose reductase-inhibitor complexes.
Topics: Aldehyde Reductase; Carboxylic Acids; Enzyme Inhibitors; Humans; Mutation, Missense; Protein Conformation; Substrate Specificity; Thermodynamics | 2006 |
Thin-layer chromatography of lipoic acid, lipoamide, and their persulfides.
Topics: Chromatography, Thin Layer; Indicators and Reagents; Sulfides; Thioctic Acid | 1979 |
Thin-layer chromatography of oxidised and reduced lipoate and lipoamide and their persulfides.
Topics: Amides; Chromatography, Thin Layer; Disulfides; Hydrolysis; Oxidation-Reduction; Solvents; Thioctic Acid | 1976 |
[Flavobion and thioctacid lessen irradiation-induced latent injury of the liver].
Topics: Animals; Chromosome Aberrations; Hepatectomy; Liver; Liver Regeneration; Male; Radiation Injuries, Experimental; Rats; Rats, Wistar; Silymarin; Thioctic Acid; Whole-Body Irradiation | 1992 |
Lipid peroxidation of erythrocyte membrane induced by lipoamide dehydrogenase in the presence of ADP-Fe3+.
Topics: Adenosine Diphosphate; Animals; Dihydrolipoamide Dehydrogenase; Erythrocyte Membrane; Free Radical Scavengers; Hydrogen Peroxide; Iron Chelating Agents; Lipid Peroxidation; Rats; Superoxide Dismutase; Thioctic Acid | 1992 |
High-performance liquid chromatography with electrochemical detection for the determination of thioctic acid and thioctic acid amide.
Topics: Chromatography, High Pressure Liquid; Electrochemistry; Thioctic Acid | 1990 |
Characterisation of the reactivity of autoantibodies in primary biliary cirrhosis.
Topics: Acetylation; Antigens; Autoantibodies; Blotting, Western; Epitopes; Escherichia coli; Ethylmaleimide; Humans; Liver Cirrhosis, Biliary; Molecular Weight; Peptide Fragments; Pyruvate Dehydrogenase Complex; Pyruvates; Pyruvic Acid; Saccharomyces cerevisiae; Thioctic Acid; Trypsin | 1989 |
Antimitochondrial antibodies in primary biliary cirrhosis recognize both specific peptides and shared epitopes of the M2 family of antigens.
Topics: Autoantibodies; Autoantigens; Cross Reactions; Dihydrolipoyllysine-Residue Acetyltransferase; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Epitopes; Humans; Immunoblotting; Liver Cirrhosis, Biliary; Mitochondria, Heart; Mitochondrial Proteins; Molecular Weight; Thioctic Acid | 1989 |
Determination of lipoyllysine derived from enzymes by liquid chromatography.
Topics: Animals; Cattle; Chromatography, High Pressure Liquid; Hydrolysis; Lysine; Myocardium; Pyruvate Dehydrogenase Complex; Thioctic Acid | 1989 |
[Use of repeat courses of unithiol in the complex treatment of liver cirrhosis].
Topics: Adult; Dimercaprol; Drug Administration Schedule; Drug Therapy, Combination; Female; Furosemide; Humans; Liver Cirrhosis; Liver Extracts; Male; Middle Aged; Spironolactone; Thioctic Acid; Unithiol | 1986 |
[Effect of unithiol and lipamide on the cardiovascular function of animals administered cadmium and copper compounds].
Topics: Animals; Antidotes; Cadmium Poisoning; Cardiovascular System; Copper; Dimercaprol; Drug Evaluation, Preclinical; Electrocardiography; Hemodynamics; Male; Rats; Thioctic Acid; Unithiol | 1987 |
[Reconstitution of high-affinity galactose transport of Salmonella typhimurium in proteoliposomes: energization by lipoamide and NAD or by the membrane potential; inhibition by ATP].
Topics: Adenosine Triphosphate; Calcium-Binding Proteins; Carrier Proteins; Cell Membrane; Galactose; Kinetics; Liposomes; Membrane Potentials; Monosaccharide Transport Proteins; NAD; Periplasmic Binding Proteins; Proteolipids; Salmonella typhimurium; Thioctic Acid | 1987 |
Thioredoxin fragment 31-36 is reduced by dihydrolipoamide and reduces oxidized protein.
Topics: Bacterial Proteins; Crystallins; Dihydrolipoamide Dehydrogenase; Disulfides; Escherichia coli; Glyceraldehyde-3-Phosphate Dehydrogenases; Insulin; Kinetics; NAD; Oxidation-Reduction; Peptide Fragments; Proteins; Spectrophotometry; Thioctic Acid; Thioredoxin-Disulfide Reductase; Thioredoxins | 1988 |
Active site-specific inhibition by 1,3-bis(2-chloroethyl)-1-nitrosourea of two genetically homologous flavoenzymes: glutathione reductase and lipoamide dehydrogenase.
Topics: Carmustine; Dihydrolipoamide Dehydrogenase; Drug Interactions; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Glutathione Reductase; Humans; In Vitro Techniques; NADP; Oxidation-Reduction; Oxidoreductases; Thioctic Acid | 1985 |
The effect of a high fat diet on pyruvate decarboxylase deficiency without central nervous system involvement.
Topics: Carboxy-Lyases; Child; Dietary Fats; Electroencephalography; Fatigue; Fibroblasts; Humans; Male; Physical Exertion; Pyruvate Decarboxylase; Pyruvate Dehydrogenase Complex Deficiency Disease; Syndrome; Thiamine; Thioctic Acid | 1983 |
The reduction of disulphides by rat liver mitochondria.
Topics: Animals; Disulfides; Glutathione; Kinetics; Mitochondria, Liver; NAD; NADP; Oxidation-Reduction; Rats; Structure-Activity Relationship; Sulfhydryl Compounds; Thioctic Acid | 1984 |
Reduction of lumichrome by the radical anions of CO2 and lipoamide.
Topics: Anions; Carbon Dioxide; Flavins; Free Radicals; Oxidation-Reduction; Thioctic Acid | 1984 |
Kinetic studies of multifunctional reactions catalysed by lipoamide dehydrogenase.
Topics: 2,6-Dichloroindophenol; Animals; Dihydrolipoamide Dehydrogenase; Ferricyanides; Kinetics; Mathematics; NAD; Swine; Thioctic Acid | 1980 |
Teratogenesis of the horseshoe crab by alpha-lipoic amide (6,8-thioctic amide) in marketed vitamin tablets.
Topics: Abnormalities, Drug-Induced; Animals; Female; Horseshoe Crabs; Limb Deformities, Congenital; Male; Thioctic Acid; Vitamins | 1980 |
Principles of symmetrical organization for the pyruvate dehydrogenase complex.
Topics: Animals; Kinetics; Protein Conformation; Pyruvate Dehydrogenase Complex; Thioctic Acid | 1995 |
Lipoamide influences substrate selection in post-ischaemic perfused rat hearts.
Topics: Acetates; Acetylation; Animals; Aspartic Acid; Binding, Competitive; Carbon Isotopes; Glutamates; Glutamic Acid; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Myocardial Ischemia; Pyruvates; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Thioctic Acid | 1994 |
Modulation of the oxidation-reduction potential of the flavin in lipoamide dehydrogenase from Escherichia coli by alteration of a nearby charged residue, K53R.
Topics: Circular Dichroism; Dihydrolipoamide Dehydrogenase; Electrochemistry; Escherichia coli; Flavin-Adenine Dinucleotide; Kinetics; Lysine; NAD; Oxidation-Reduction; Photochemistry; Spectrometry, Fluorescence; Spectrophotometry; Thioctic Acid | 1994 |
Microsomal lipoamide reductase provides vitamin K epoxide reductase with reducing equivalents.
Topics: Animals; Dihydrolipoamide Dehydrogenase; Dithiothreitol; Microsomes, Liver; Mixed Function Oxygenases; NADH, NADPH Oxidoreductases; Rats; Salicylates; Salicylic Acid; Thioctic Acid; Vitamin K Epoxide Reductases; Warfarin | 1994 |
Three-dimensional structure of lipoamide dehydrogenase from Pseudomonas fluorescens at 2.8 A resolution. Analysis of redox and thermostability properties.
Topics: Amino Acid Sequence; Azotobacter vinelandii; Binding Sites; Catalysis; Crystallization; Dihydrolipoamide Dehydrogenase; Electronic Data Processing; Flavin-Adenine Dinucleotide; Hydrogen Bonding; Models, Molecular; Molecular Sequence Data; Mutation; NAD; Oxidation-Reduction; Protein Conformation; Protein Denaturation; Pseudomonas fluorescens; Recombinant Proteins; Sequence Homology, Amino Acid; Thioctic Acid; X-Ray Diffraction | 1993 |
Efficient reduction of lipoamide and lipoic acid by mammalian thioredoxin reductase.
Topics: Animals; Cattle; Chromatography, Ion Exchange; Female; Humans; Kinetics; Liver; Mammals; Oxidation-Reduction; Placenta; Pregnancy; Rats; Substrate Specificity; Thioctic Acid; Thioredoxin-Disulfide Reductase; Thymus Gland | 1996 |
Direct determination of glutathione in human blood by micellar electrokinetic chromatography: simultaneous determination of lipoamide and lipoic acid.
Topics: Benzenesulfonates; Chromatography; Electrochemistry; Glutathione; Humans; Kinetics; Micelles; Oxidation-Reduction; Salicylates; Thioctic Acid | 1996 |
Early redox changes during rat thymocyte apoptosis.
Topics: Animals; Apoptosis; Fluoresceins; Glutathione; Glutathione Peroxidase; Hydrogen Peroxide; Lipid Peroxides; Male; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Thioctic Acid; Thymus Gland; Time Factors | 1997 |
Regulation of cellular thiols in human lymphocytes by alpha-lipoic acid: a flow cytometric analysis.
Topics: Acetylcysteine; Caprylates; Cell Size; DNA; Flow Cytometry; Fluorescence; Fluorescent Dyes; Glutamic Acid; Glutamine; Glutathione; Humans; Jurkat Cells; Kinetics; Lymphocytes; Male; Sulfhydryl Compounds; T-Lymphocytes; Thioctic Acid | 1997 |
Antioxidant reactions of dihydrolipoic acid and lipoamide with triplet duroquinone.
Topics: Antioxidants; Benzoquinones; Free Radicals; Kinetics; Lasers; Photolysis; Spectrum Analysis, Raman; Thioctic Acid | 1998 |
Modulation of erythrocyte photohemolysis rate by glutathione reductase inactivating alkylating agents.
Topics: Alkylating Agents; Carmustine; Glutathione Reductase; Hemolysis; Humans; Kinetics; Light; Melphalan; Oxidation-Reduction; Oxygen; Oxygen Consumption; Phenylacetates; Photolysis; Photosensitizing Agents; Singlet Oxygen; Thioctic Acid | 1998 |
Highly immunogenic and fully synthetic peptide-carrier constructs targetting GnRH.
Topics: Adjuvants, Immunologic; Animals; Antibodies; Dose-Response Relationship, Immunologic; Drug Carriers; Emulsions; Freund's Adjuvant; Gonadotropin-Releasing Hormone; Hemocyanins; Male; Orchiectomy; Organ Size; Palmitic Acid; Peptides; Polylysine; Radioimmunoassay; Repetitive Sequences, Amino Acid; Swine; Testis; Thioctic Acid; Vaccines, Synthetic | 1999 |
Investigation of the local structure and dynamics of the H subunit of the mitochondrial glycine decarboxylase using heteronuclear NMR spectroscopy.
Topics: Amino Acid Oxidoreductases; Carbon Isotopes; Glycine Decarboxylase Complex; Glycine Decarboxylase Complex H-Protein; Glycine Dehydrogenase (Decarboxylating); Methylamines; Mitochondria; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Pisum sativum; Plant Proteins; Protein Conformation; Protons; Temperature; Thermodynamics; Thioctic Acid | 1999 |
Theoretical study of the conformation of the H-protein lipoamide arm as a function of its terminal group.
Topics: Amino Acid Oxidoreductases; Carrier Proteins; Computer Simulation; Crystallization; Glycine Decarboxylase Complex; Glycine Decarboxylase Complex H-Protein; Glycine Dehydrogenase (Decarboxylating); Methylamines; Mitochondria; Models, Molecular; Oxidation-Reduction; Plant Leaves; Protein Conformation; Solvents; Static Electricity; Thermodynamics; Thioctic Acid; Water | 1999 |
Crystal structure of 2-oxoisovalerate and dehydrogenase and the architecture of 2-oxo acid dehydrogenase multienzyme complexes.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Acylation; Binding Sites; Crystallography, X-Ray; Hemiterpenes; Keto Acids; Ketone Oxidoreductases; Models, Molecular; Multienzyme Complexes; Protein Binding; Protein Conformation; Recombinant Proteins; Thioctic Acid | 1999 |
Enhanced ADP-ribosylation and its diminution by lipoamide after ischemia-reperfusion in perfused rat heart.
Topics: Adenosine Diphosphate Ribose; ADP Ribose Transferases; Animals; Antioxidants; DNA Damage; Enzyme Activation; In Vitro Techniques; Lipid Peroxidation; Male; Mitochondria, Heart; Myocardial Reperfusion Injury; NAD; Perfusion; Poly(ADP-ribose) Polymerases; Proteins; Rats; Rats, Wistar; Reactive Oxygen Species; Thioctic Acid | 1999 |
Interaction between the lipoamide-containing H-protein and the lipoamide dehydrogenase (L-protein) of the glycine decarboxylase multienzyme system. 1. Biochemical studies.
Topics: Amino Acid Oxidoreductases; beta 2-Glycoprotein I; Carrier Proteins; Catalysis; Dihydrolipoamide Dehydrogenase; Escherichia coli; Glycine Decarboxylase Complex H-Protein; Glycine Dehydrogenase (Decarboxylating); Glycoproteins; Hydrogen-Ion Concentration; Indicators and Reagents; Kinetics; Mitochondria; Models, Chemical; Phosphines; Pisum sativum; Plant Proteins; Protein Binding; Protein Folding; Recombinant Proteins; Stereoisomerism; Thioctic Acid | 2000 |
Oxidative stress promotes specific protein damage in Saccharomyces cerevisiae.
Topics: Fungal Proteins; Hydrogen Peroxide; Oxidation-Reduction; Oxidative Stress; Saccharomyces cerevisiae; Thioctic Acid; Vitamin K | 2000 |
Synthesis and characterization of selenotrisulfide-derivatives of lipoic acid and lipoamide.
Topics: Animals; Cattle; Chromatography, High Pressure Liquid; Dihydrolipoamide Dehydrogenase; Humans; Hydrogen-Ion Concentration; Molecular Structure; Oxidation-Reduction; Rats; Recombinant Proteins; Selenium Compounds; Sodium Selenite; Sulfides; Thioctic Acid; Thioredoxin-Disulfide Reductase | 2000 |
Reaction mechanism for mammalian pyruvate dehydrogenase using natural lipoyl domain substrates.
Topics: Acetylation; Acetyltransferases; Animals; Cattle; Circular Dichroism; Dihydrolipoamide Dehydrogenase; Dihydrolipoyllysine-Residue Acetyltransferase; Humans; Kinetics; Models, Molecular; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Pyruvate Dehydrogenase Complex; Pyruvic Acid; Thermodynamics; Thiamine Pyrophosphate; Thioctic Acid | 2001 |
Theoretical study of the conformation of the lipoamide arm in a mutant H protein.
Topics: Alanine; Amino Acid Oxidoreductases; Amino Acid Substitution; Carrier Proteins; Computer Simulation; Crystallography, X-Ray; Glutamic Acid; Glycine Decarboxylase Complex; Glycine Decarboxylase Complex H-Protein; Glycine Dehydrogenase (Decarboxylating); Methylamines; Models, Molecular; Mutation; Nuclear Magnetic Resonance, Biomolecular; Protein Conformation; Thermodynamics; Thioctic Acid | 2001 |
Alpha-lipoic acid and alpha-lipoamide prevent oxidant-induced lysosomal rupture and apoptosis.
Topics: Animals; Antioxidants; Apoptosis; Cells, Cultured; Deferoxamine; Hydrogen Peroxide; Iron Chelating Agents; Lysosomes; Oxidants; Oxidative Stress; Thioctic Acid | 2001 |
Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein.
Topics: Acyltransferases; Amino Acid Sequence; Antioxidants; Binding Sites; Catalysis; Cloning, Molecular; Crystallization; Crystallography, X-Ray; Dihydrolipoamide Dehydrogenase; Hydrogen Bonding; Hydrogen Peroxide; Models, Molecular; Molecular Sequence Data; Mycobacterium tuberculosis; NAD; Oxidation-Reduction; Oxidoreductases; Peroxidases; Peroxiredoxins; Peroxynitrous Acid; Protein Conformation; Protein Folding; Protein Structure, Quaternary; Thioctic Acid; Thioredoxins | 2002 |
The lipoamide dehydrogenase from Mycobacterium tuberculosis permits the direct observation of flavin intermediates in catalysis.
Topics: Bacterial Proteins; Catalysis; Dihydrolipoamide Dehydrogenase; Electron Transport; Flavin-Adenine Dinucleotide; Models, Chemical; Mycobacterium tuberculosis; NAD; Oxidation-Reduction; Spectrophotometry; Spectrophotometry, Ultraviolet; Thermodynamics; Thioctic Acid | 2002 |
Histidine 407, a phantom residue in the E1 subunit of the Escherichia coli pyruvate dehydrogenase complex, activates reductive acetylation of lipoamide on the E2 subunit. An explanation for conservation of active sites between the E1 subunit and transketo
Topics: Acetylation; Acetyltransferases; Alanine; Binding Sites; Calorimetry; Conserved Sequence; Dihydrolipoyllysine-Residue Acetyltransferase; Enzyme Activation; Escherichia coli Proteins; Histidine; Multienzyme Complexes; Mutagenesis, Site-Directed; Oxidation-Reduction; Protein Structure, Tertiary; Pyruvate Dehydrogenase (Lipoamide); Pyruvate Dehydrogenase Complex; Recombinant Proteins; Saccharomyces cerevisiae Proteins; Thioctic Acid; Titrimetry; Transketolase | 2002 |
Catalysis of diaphorase reactions by Mycobacterium tuberculosis lipoamide dehydrogenase occurs at the EH4 level.
Topics: Bacterial Proteins; Benzoquinones; Catalysis; Dihydrolipoamide Dehydrogenase; Flavin-Adenine Dinucleotide; Kinetics; Mycobacterium tuberculosis; NAD; Oxidants; Oxidation-Reduction; Oxygen; Pentanoic Acids; Recombinant Proteins; Spectrophotometry; Substrate Specificity; Thioctic Acid | 2003 |
Prevention of oxidant-induced cell death by lysosomotropic iron chelators.
Topics: Animals; Antioxidants; Apoptosis; Caspases; Cells, Cultured; Deferoxamine; Electron Spin Resonance Spectroscopy; Enzyme Activation; Free Radicals; Hydrogen Peroxide; Hydroxyl Radical; Iron; Iron Chelating Agents; Lysosomes; Macrophages; Membrane Potentials; Mice; Mitochondria; Oxidation-Reduction; Oxidative Stress; Thioctic Acid | 2003 |
A study on the metabolism of lipoic acid and lipoamide.
Topics: Biochemical Phenomena; Humans; Lipid Metabolism; Thioctic Acid | 1961 |
Alpha lipoic acid inhibits human T-cell migration: implications for multiple sclerosis.
Topics: Antioxidants; Cell Count; Cell Line; Cell Movement; Dipeptides; Dose-Response Relationship, Drug; Drug Interactions; Electrophoresis; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Gene Expression Regulation, Developmental; Humans; Matrix Metalloproteinase 9; Protease Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; T-Lymphocytes; Thioctic Acid | 2004 |
Amino-terminal residues 1-45 of the Escherichia coli pyruvate dehydrogenase complex E1 subunit interact with the E2 subunit and are required for activity of the complex but not for reductive acetylation of the E2 subunit.
Topics: Acetylation; Amino Acid Sequence; Amino Acid Substitution; Chromatography, High Pressure Liquid; Dihydrolipoyllysine-Residue Acetyltransferase; Dimerization; Enzyme Activation; Enzyme Stability; Escherichia coli Proteins; Genetic Variation; Hot Temperature; Hydrolysis; Mass Spectrometry; Molecular Sequence Data; Molecular Weight; Oxidation-Reduction; Peptide Fragments; Peptide Mapping; Protein Binding; Protein Structure, Tertiary; Protein Subunits; Pyruvate Dehydrogenase (Lipoamide); Pyruvate Dehydrogenase Complex; Sequence Deletion; Thioctic Acid; Trypsin | 2004 |
Structure of P-protein of the glycine cleavage system: implications for nonketotic hyperglycinemia.
Topics: Amino Acid Oxidoreductases; Amino Acid Sequence; Bacterial Proteins; Binding Sites; Crystallography, X-Ray; Dimerization; Glycine Decarboxylase Complex H-Protein; Glycine Dehydrogenase (Decarboxylating); Humans; Hyperglycinemia, Nonketotic; Models, Molecular; Molecular Sequence Data; Protein Binding; Protein Structure, Quaternary; Protein Subunits; Sequence Alignment; Thermus thermophilus; Thioctic Acid | 2005 |
Cellular disulfide-reducing capacity: an integrated measure of cell redox capacity.
Topics: Cell Line; Disulfides; Dithionitrobenzoic Acid; Endothelial Cells; Glutathione; Humans; NADH, NADPH Oxidoreductases; Oxidation-Reduction; Thioctic Acid | 2006 |
Modifications of the lipoamide-containing mitochondrial subproteome in a yeast mutant defective in cysteine desulfurase.
Topics: Carbon-Sulfur Lyases; Electrophoresis, Gel, Two-Dimensional; Mass Spectrometry; Mitochondria; Mitochondrial Membranes; Mutation; Proteome; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Thioctic Acid | 2006 |
Recognition of the inner lipoyl-bearing domain of dihydrolipoyl transacetylase and of the blood glucose-lowering compound AZD7545 by pyruvate dehydrogenase kinase 2.
Topics: Anilides; Animals; Binding Sites; Circular Dichroism; Dihydrolipoyllysine-Residue Acetyltransferase; Humans; Hypoglycemic Agents; Mutagenesis, Site-Directed; Point Mutation; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Rats; Thioctic Acid | 2007 |
Effects of zinc on SN56 cholinergic neuroblastoma cells.
Topics: Acetyl Coenzyme A; Acetylcholine; Aconitate Hydratase; Adenosine Triphosphate; Animals; Cell Line, Tumor; Choline O-Acetyltransferase; Citric Acid Cycle; Dose-Response Relationship, Drug; Energy Metabolism; Enzyme Activation; Enzyme Inhibitors; Glycolysis; Mice; Nerve Degeneration; Neuroblastoma; Neurons; Neurotoxins; Pyruvate Dehydrogenase Complex; Thioctic Acid; Zinc | 2007 |
Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction.
Topics: Acrolein; DNA Damage; Free Radicals; Gene Expression Regulation; Glutathione Transferase; Humans; Lipid Peroxidation; Mitochondria; Models, Biological; Oxidative Stress; Pigment Epithelium of Eye; Smoke; Superoxide Dismutase; Tetrazolium Salts; Thiazoles; Thioctic Acid | 2008 |
Triazaspirodimethoxybenzoyls as selective inhibitors of mycobacterial lipoamide dehydrogenase .
Topics: Animals; Antitubercular Agents; Binding Sites; Cell Survival; Cells, Cultured; Crystallography, X-Ray; Dihydrolipoamide Dehydrogenase; Enzyme Inhibitors; Macrophages; Mice; Models, Biological; Molecular Structure; Mutagenesis, Site-Directed; Mycobacterium tuberculosis; NAD; Structure-Activity Relationship; Thioctic Acid | 2010 |
Improved functionality of antibody-colloidal gold conjugates with the aid of lipoamide-grafted N-[tris(hydroxymethyl)methyl]acrylamide polymers.
Topics: Acrylamides; Gold Colloid; Humans; Immunoassay; Immunoconjugates; Immunoglobulin G; Nanoparticles; Particle Size; Polymers; Surface Plasmon Resonance; Thioctic Acid | 2010 |
Lipoic acid stimulates cAMP production via G protein-coupled receptor-dependent and -independent mechanisms.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Calcium Signaling; Cyclic AMP; Dinoprostone; Egtazic Acid; HEK293 Cells; Humans; Killer Cells, Natural; Leukocytes, Mononuclear; Receptors, G-Protein-Coupled; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP4 Subtype; Thioctic Acid | 2011 |
Lipoamide or lipoic acid stimulates mitochondrial biogenesis in 3T3-L1 adipocytes via the endothelial NO synthase-cGMP-protein kinase G signalling pathway.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Base Sequence; Carnitine O-Palmitoyltransferase; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; DNA Primers; DNA, Mitochondrial; Hypoglycemic Agents; Mice; Microscopy, Electron, Transmission; Mitochondria; Mitochondrial Proteins; Nitric Oxide Synthase Type III; Oxygen Consumption; PPAR alpha; PPAR gamma; RNA, Messenger; Signal Transduction; Thioctic Acid | 2011 |
Substrate and inhibitor specificities differ between human cytosolic and mitochondrial thioredoxin reductases: Implications for development of specific inhibitors.
Topics: Animals; Antioxidants; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Cisplatin; Cytosol; Dithionitrobenzoic Acid; Enzyme Inhibitors; Humans; Mice; Mitochondria; Naphthoquinones; Organogold Compounds; Oxidation-Reduction; Recombinant Proteins; Substrate Specificity; Thioctic Acid; Thioredoxin Reductase 1; Thioredoxin Reductase 2; Thioredoxins | 2011 |
Five new amicoumacins isolated from a marine-derived bacterium Bacillus subtilis.
Topics: Anti-Bacterial Agents; Aquatic Organisms; Bacillus subtilis; Coumarins; Drug Discovery; Fermentation; Gram-Negative Bacteria; Gram-Positive Bacteria; HeLa Cells; Humans; Indian Ocean; Inhibitory Concentration 50; Microbial Sensitivity Tests; Molecular Structure; Proteobacteria; Structure-Activity Relationship; Thioctic Acid | 2012 |
Glutathionylation of α-ketoglutarate dehydrogenase: the chemical nature and relative susceptibility of the cofactor lipoic acid to modification.
Topics: Animals; Calcium; Glutathione; Ketoglutarate Dehydrogenase Complex; Male; Myocardium; Rats; Rats, Sprague-Dawley; Thioctic Acid | 2013 |
Scavenging of blood glutamate for enhancing brain-to-blood glutamate efflux.
Topics: Animals; Blood-Brain Barrier; Brain; Free Radical Scavengers; Glutamic Acid; Oxaloacetic Acid; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Thioctic Acid | 2014 |
Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase.
Topics: Antitubercular Agents; Arginine; Bacterial Proteins; Benzeneacetamides; Binding Sites; Biological Transport; Cell Membrane; Cell Membrane Permeability; Dihydrolipoamide Dehydrogenase; Drug Evaluation, Preclinical; Enzyme Inhibitors; High-Throughput Screening Assays; Humans; Membrane Transport Modulators; Microbial Sensitivity Tests; Molecular Conformation; Mutant Proteins; Mycobacterium tuberculosis; Recombinant Proteins; Small Molecule Libraries; Structure-Activity Relationship; Sulfonamides; Thioctic Acid | 2013 |
Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity.
Topics: Amidohydrolases; Animals; Gene Knockdown Techniques; Glutamine; Humans; Liver; Mice; Mitochondria; Mitochondrial Proteins; Pyruvate Dehydrogenase Complex; Rats; Sirtuins; Thioctic Acid | 2014 |
Lipoamide Acts as an Indirect Antioxidant by Simultaneously Stimulating Mitochondrial Biogenesis and Phase II Antioxidant Enzyme Systems in ARPE-19 Cells.
Topics: Antioxidants; Cell Line; DNA Copy Number Variations; DNA, Mitochondrial; Electron Transport; Enzymes; Humans; NF-E2-Related Factor 2; Organelle Biogenesis; Retinal Pigment Epithelium; Thioctic Acid; Transcription Factors | 2015 |
Staphylococcus aureus SufT: an essential iron-sulphur cluster assembly factor in cells experiencing a high-demand for lipoic acid.
Topics: Aconitate Hydratase; Bacterial Proteins; Citric Acid Cycle; Escherichia coli Proteins; Iron; Iron-Sulfur Proteins; Staphylococcal Infections; Staphylococcus aureus; Sulfur; Thioctic Acid; Transcription Factors | 2016 |
Lipoamide Inhibits NF1 Deficiency-induced Epithelial-Mesenchymal Transition in Murine Schwann Cells.
Topics: Animals; Blotting, Western; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Epithelial-Mesenchymal Transition; Genes, Neurofibromatosis 1; Male; Mice; Mice, Nude; Neurofibroma; Neurofibromatosis 1; Neurofibromin 1; Reactive Oxygen Species; Schwann Cells; Thioctic Acid; Up-Regulation; Wound Healing | 2017 |
Antibodies to post-translationally modified mitochondrial peptide PDC-E2(167-184) in type 1 diabetes.
Topics: Adult; Antibodies; Diabetes Mellitus, Type 1; Female; Glycosylation; Humans; Male; Mitochondrial Proteins; Peptide Fragments; Phosphorylation; Protein Processing, Post-Translational; Stereoisomerism; Thioctic Acid | 2018 |
[Alpha-lipoamide inhibits renal inflammation and collagen 4 production in diabetic rats and its mechanism].
Topics: Animals; Collagen Type IV; Diabetes Mellitus, Experimental; Inflammation; Interleukin-6; Kidney; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Rats, Sprague-Dawley; Receptor, Notch2; Streptozocin; Thioctic Acid; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2018 |
Lipoamide Ameliorates Oxidative Stress via Induction of Nrf2/ARE Signaling Pathway in PC12 Cells.
Topics: Animals; Antioxidant Response Elements; Neurons; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; PC12 Cells; Rats; Signal Transduction; Thioctic Acid | 2019 |
Glutathione-dependent thioredoxin reduction and lipoamide system support in-vitro mammalian ribonucleotide reductase catalysis: a possible antioxidant redundancy.
Topics: Animals; Antioxidants; Catalysis; Glutathione; Mammals; Mice; Oxidation-Reduction; Ribonucleotide Reductases; Ribonucleotides; Thioctic Acid; Thioredoxin-Disulfide Reductase; Thioredoxins | 2022 |
Alpha lipoamide inhibits diabetic kidney fibrosis via improving mitochondrial function and regulating RXRα expression and activation.
Topics: Animals; beta Catenin; Cystic Fibrosis Transmembrane Conductance Regulator; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Epithelial-Mesenchymal Transition; Fibrosis; Glucose; Kidney; Mice; Mitochondria; Rats; Retinoid X Receptor alpha; Thioctic Acid | 2023 |