Page last updated: 2024-08-22

thiocholchicine and colchicine

thiocholchicine has been researched along with colchicine in 56 studies

Research

Studies (56)

Timeframe	Studies, this research(%)	All Research%
pre-1990	15 (26.79)	18.7374
1990's	14 (25.00)	18.2507
2000's	11 (19.64)	29.6817
2010's	9 (16.07)	24.3611
2020's	7 (12.50)	2.80

Authors

Authors	Studies
Brossi, A; Hamel, E; Lin, CM; Muzaffar, A	1
Brossi, A; Chignell, CF; Dumont, R; Quinn, FR; Suffness, M	1
Brossi, A; Chignell, CF; Kerekes, P; Quinn, FR; Sharma, PN	1
Beisler, JA; Neiman, Z; Quinn, FR	1
Beisler, JA; Quinn, FR	1
Atwell, L; Brossi, A; Capraro, HG; Chignell, CF; Iorio, MA; Jacobson, AE; Rösner, M; Sik, RH; Williams, TH	1
Hamel, E; Hastie, SB; Lee, KH; Lin, CM; Pyluck, A; Sun, L	1
Chang, JJ; Hamel, E; Hastie, SB; Lee, KH; Lin, CM; McPhail, AT; Sun, L	1
Brossi, A; Hamel, E; Lee, KH; McPhail, AT; Shi, Q; Verdier-Pinard, P	1
Bastow, KF; Brossi, A; Guan, J; Hamel, E; Lee, KH; Tachibana, Y; Zhu, XK	1
Bombardelli, E; De Vincenzo, R; Gelmi, ML; Mottadelli, S; Pocar, D; Riva, A; Scambia, G	1
Brossi, A; Feng, J; Hamel, E; Kuo, SC; Lee, KH; Tropsha, A; Zhang, SX	1
Lee, KH	2
Bastow, KF; Brossi, A; Hamel, E; Kozaka, T; Lai, CY; Lee, KH; Nakagawa-Goto, K; Shi, Q	1
Barczyński, P; Cofta, G; Jasiewicz, B; Kurczab, R; Kurek, J; Kwaśniewska-Sip, P; Murias, M; Myszkowski, K	1
Al-Bajalan, HM; Alali, FQ; Chong, KF; Ghawanmeh, AA; Mackeen, MM	1
Beletskaya, IP; Fedorov, AY; Gracheva, IA; Schmalz, HG; Shchegravina, ES	1
Chambers, TC; Huczyński, A; Klejborowska, G; Maj, E; Moshari, M; Preto, J; Tuszynski, JA; Urbaniak, A; Wietrzyk, J	2
Czerwonka, D; Huczyński, A; Maj, E; Wietrzyk, J	1
Brossi, A; Gotfried, M; Jedeikin, A; Lishner, M; Ravid, M; Wolach, B	1
Cammardella, MP; Carossino, D; Casigliani, R; Launo, C; Orlandini, G; Palermo, S; Riello, R	1
Angström, J; Deinum, J; Lincoln, P; Nordén, B; Nordh, J	1
Brossi, A; Getahun, Z; Hamel, E; Kang, GJ; Muzaffar, A	1
Chabin, RM; Hastie, SB	1
Brossi, A; Hamel, E; Lee, KH; Shi, Q; Verdier-Pinard, P	1
Benedetti Panici, P; Bombardelli, E; De Vincenzo, R; Distefano, M; Ferlini, C; Filippini, P; Gelmi, ML; Mancuso, S; Pocar, D; Riva, A; Scambia, G	1
Banerjee, A; Hamel, E; Kasmala, LT; Lee, KH; Sun, L	1
Bombardelli, E; Capelli, G; Danieli, B; De Vincenzo, R; Distefano, M; Ferlini, C; Gaggini, C; Mancuso, S; Morazzoni, P; Riva, A; Scambia, G	1
Brecht, R; Guénard, D; Seitz, G; Thoret, S	1
Belisario, JC	1
Ambrogini, P; Bombardelli, E; Bruno, C; Cecchini, T; Ciaroni, S; Cuppini, R; Del Grande, P; Ferri, P; Guidi, L; Morazzoni, P; Riva, A	1
Fang, WS; Pan, XD	1
BRANCENI, D; JEQUIER, R; PETERFALVI, M	1
BOUSSER, J; CHRISTOL, D	1
SARACINO, R; TRUHAUT, R	1
AUBRY, R	1
HUANT, E	2
FAUCOUNAU, N; MARAUD, R; STOLL, R	1
BASTIN, JP; JORIS, H	1
Das, N; Ferlini, C; Gallo, D; Mozzetti, S; Prislei, S; Raspaglio, G; Scambia, G	1
Cho, KH; Chun, KW; Kim, JM; Kim, KH; Kim, MH; Lee, SH; Namgoong, SK; Park, SK; Youn, JY	1
Danieli, B; Giardini, A; Lesma, G; Passarella, D; Peretto, B; Pratesi, G; Sacchetti, A; Silvani, A; Zunino, F	1
Appendino, G; Bombardelli, E; Danieli, B; Fontana, G; Giardini, A; Lesma, G; Noncovich, A; Passarella, D; Silvani, A; Sterner, O	1
Liu, HY; Lü, ZY; Pan, XD; Wang, B; Yang, J; Zhao, JH	1
Borlak, J; Cappelletti, G; Cartelli, D; Danieli, B; Fontana, G; Giardini, A; Passarella, D; Peretto, B; Ronchi, C; Sacchetti, A; Silvani, A	1
Blasco y Yepes, R; Borlak, J; Cappelletti, G; Cartelli, D; Danieli, B; Fontana, G; Passarella, D; Peretto, B; Ronchi, C; Snaith, J	1
Bartusik, D; Fallone, G; Lattová, E; Perreault, H; Tomanek, B; Tuszynski, J	1
Acquati, V; Berlanda, D; Cabri, W; Ciceri, D; Ciulla, R; Donzelli, F; Evangelista, D; Fata, E; Negrini, A; Perterlongo, F; Ponzone, C; Rovati, M	1
Chang, YJ; Ho, CT; Liu, JJ; Liu, TZ; Wei, PL; Yang, LX	1
Bartl, F; Chambers, TC; Delgado, M; Huczyński, A; Maj, E; Majcher, U; Moshari, M; Tuszynski, JA; Urbaniak, A; Wietrzyk, J	1
Huczyński, A; Klejborowska, G; Maj, E; Majcher, U; Moshari, M; Preto, J; Tuszynski, JA; Wietrzyk, J	1
Bonandi, E; Christodoulou, MS; Dapiaggi, F; de Asís Balaguer, F; Díaz, JF; Foschi, F; Marucci, C; Passarella, D; Pieraccini, S; Sironi, M; Zidar, N	1
Czerwonka, D; Huczyński, A; Katrusiak, A; Maj, E; Sobczak, S; Wietrzyk, J	1

Reviews

5 review(s) available for thiocholchicine and colchicine

Article	Year
Current developments in the discovery and design of new drug candidates from plant natural product leads. Journal of natural products, 2004, Volume: 67, Issue:2 Topics: Anti-HIV Agents; Antineoplastic Agents; Biological Factors; Drug Design; Molecular Structure; Plants, Medicinal; Structure-Activity Relationship	2004
Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach. Journal of natural products, 2010, Mar-26, Volume: 73, Issue:3 Topics: Anti-HIV Agents; Biological Factors; Drug Design; Molecular Structure; Pharmaceutical Preparations; Plants, Medicinal	2010
Recent developments on (-)-colchicine derivatives: Synthesis and structure-activity relationship. European journal of medicinal chemistry, 2020, Jan-01, Volume: 185 Topics: Antineoplastic Agents, Phytogenic; Cell Proliferation; Colchicine; Humans; Molecular Structure; Neoplasms	2020
Colchicine Alkaloids and Synthetic Analogues: Current Progress and Perspectives. Journal of medicinal chemistry, 2020, 10-08, Volume: 63, Issue:19 Topics: Alkaloids; Binding Sites; Colchicine; Polymerization; Structure-Activity Relationship; Tubulin	2020
Recent progress in structure-activity relationship studies on the anticancer drug colchicine and its analogues. Yao xue xue bao = Acta pharmaceutica Sinica, 2002, Volume: 37, Issue:10 Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Division; Colchicine; Humans; Molecular Structure; Structure-Activity Relationship; Tubulin; Tumor Cells, Cultured	2002

Other Studies

51 other study(ies) available for thiocholchicine and colchicine

Article	Year
Antitubulin effects of derivatives of 3-demethylthiocolchicine, methylthio ethers of natural colchicinoids, and thioketones derived from thiocolchicine. Comparison with colchicinoids. Journal of medicinal chemistry, 1990, Volume: 33, Issue:2 Topics: Animals; Antineoplastic Agents; Cattle; Cell Division; Chemical Phenomena; Chemistry; Colchicine; In Vitro Techniques; Ketones; Leukemia L1210; Polymers; Protein Binding; Structure-Activity Relationship; Sulfides; Tubulin; Tumor Cells, Cultured	1990
A novel synthesis of colchicide and analogues from thiocolchicine and congeners: reevaluation of colchicide as a potential antitumor agent. Journal of medicinal chemistry, 1987, Volume: 30, Issue:4 Topics: Animals; Antineoplastic Agents; Colchicine; Mice; Neoplasms, Experimental; Structure-Activity Relationship; Tubulin	1987
Synthesis and biological effects of novel thiocolchicines. 3. Evaluation of N-acyldeacetylthiocolchicines, N-(alkoxycarbonyl) deacetylthiocolchicines, and O-ethyldemethylthiocolchicines. New synthesis of thiodemecolcine and antileukemic effects of 2-demet Journal of medicinal chemistry, 1985, Volume: 28, Issue:9 Topics: Animals; Binding, Competitive; Chemical Phenomena; Chemistry; Colchicine; Demecolcine; Drug Evaluation; Lethal Dose 50; Leukemia P388; Leukemia, Experimental; Mice; Structure-Activity Relationship; Tubulin	1985
Toxicity quantitative structure--activity relationships of colchicines. Journal of medicinal chemistry, 1981, Volume: 24, Issue:5 Topics: Animals; Chemical Phenomena; Chemistry; Colchicine; Lethal Dose 50; Mice; Structure-Activity Relationship	1981
Quantitative structure-activity relationships of colchicines against P388 leukemia in mice. Journal of medicinal chemistry, 1981, Volume: 24, Issue:3 Topics: Animals; Colchicine; Leukemia P388; Leukemia, Experimental; Mathematics; Mice; Structure-Activity Relationship	1981
Biological effects of modified colchicines. Improved preparation of 2-demethylcolchicine, 3-demethylcolchicine, and (+)-colchicine and reassignment of the position of the double bond in dehydro-7-deacetamidocolchicines. Journal of medicinal chemistry, 1981, Volume: 24, Issue:3 Topics: Animals; Colchicine; Leukemia P388; Mice; Microtubules; Structure-Activity Relationship	1981
Antitumor agents. 141. Synthesis and biological evaluation of novel thiocolchicine analogs: N-acyl-, N-aroyl-, and N-(substituted benzyl)deacetylthiocolchicines as potent cytotoxic and antimitotic compounds. Journal of medicinal chemistry, 1993, May-14, Volume: 36, Issue:10 Topics: Antineoplastic Agents; Circular Dichroism; Colchicine; Humans; Structure-Activity Relationship; Tubulin; Tumor Cells, Cultured	1993
Antitumor agents. 139. Synthesis and biological evaluation of thiocolchicine analogs 5,6-dihydro-6(S)-(acyloxy)- and 5,6-dihydro-6(S)-[(aroyloxy)methyl]-1,2,3-trimethoxy-9-(methylthio)-8H- cyclohepta[a]naphthalen-8-ones as novel cytotoxic and antimitotic Journal of medicinal chemistry, 1993, Mar-05, Volume: 36, Issue:5 Topics: Animals; Antineoplastic Agents; Cattle; Colchicine; Guanosine Triphosphate; Humans; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Structure; Structure-Activity Relationship; Tubulin; Tubulin Modulators; Tumor Cells, Cultured; X-Ray Diffraction	1993
Antitumor agents. 172. Synthesis and biological evaluation of novel deacetamidothiocolchicin-7-ols and ester analogs as antitubulin agents. Journal of medicinal chemistry, 1997, Mar-14, Volume: 40, Issue:6 Topics: Antineoplastic Agents; Cell Division; Colchicine; Crystallography, X-Ray; Esters; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Molecular; Molecular Structure; Tubulin; Tubulin Modulators; Tumor Cells, Cultured	1997
Antitumor agents. 185. Synthesis and biological evaluation of tridemethylthiocolchicine analogues as novel topoisomerase II inhibitors. Journal of medicinal chemistry, 1998, May-21, Volume: 41, Issue:11 Topics: Antineoplastic Agents; Cell Division; Colchicine; DNA; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; KB Cells; Topoisomerase II Inhibitors; Tubulin; Tubulin Modulators; Tumor Cells, Cultured	1998
N-deacetyl-N-aminoacylthiocolchicine derivatives: synthesis and biological evaluation on MDR-positive and MDR-negative human cancer cell lines. Journal of medicinal chemistry, 1999, Dec-16, Volume: 42, Issue:25 Topics: Antineoplastic Agents; Cell Division; Colchicine; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Tumor Cells, Cultured	1999
Antitumor agents. 199. Three-dimensional quantitative structure-activity relationship study of the colchicine binding site ligands using comparative molecular field analysis. Journal of medicinal chemistry, 2000, Jan-27, Volume: 43, Issue:2 Topics: Antineoplastic Agents; Colchicine; Molecular Structure; Static Electricity; Structure-Activity Relationship	2000
Antitumor agents 273. Design and synthesis of N-alkyl-thiocolchicinoids as potential antitumor agents. Bioorganic & medicinal chemistry letters, 2010, Jul-15, Volume: 20, Issue:14 Topics: Antineoplastic Agents; Cell Line, Tumor; Colchicine; Drug Screening Assays, Antitumor; Humans	2010
7-Deacetyl-10-alkylthiocolchicine derivatives - new compounds with potent anticancer and fungicidal activity. MedChemComm, 2018, Oct-01, Volume: 9, Issue:10 Topics:	2018
Synthesis, anticancer activity and molecular docking studies of N-deacetylthiocolchicine and 4-iodo-N-deacetylthiocolchicine derivatives. Bioorganic & medicinal chemistry, 2021, 02-15, Volume: 32 Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Proliferation; Cell Survival; Cells, Cultured; Colchicine; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Mice; Mice, Inbred BALB C; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship	2021
Synthesis of thiocolchicine amine derivatives and evaluation of their antiproliferative activity. Bioorganic & medicinal chemistry letters, 2021, 11-15, Volume: 52 Topics: 3T3 Cells; Amines; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Colchicine; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Mice; Mice, Inbred BALB C; Molecular Structure; Structure-Activity Relationship	2021
Colchicine analogues: effect on amyloidogenesis in a murine model and, in vitro, on polymorphonuclear leukocytes. European journal of clinical investigation, 1992, Volume: 22, Issue:9 Topics: Amyloid; Amyloidosis; Animals; Chemotaxis; Colchicine; Humans; Mice; Neutrophils; Phagocytosis	1992
[TENS + mesotherapy association in the therapy of cervico-brachialgia: preliminary data]. Minerva anestesiologica, 1991, Volume: 57, Issue:10 Topics: Adult; Aged; Aged, 80 and over; Brachial Plexus Neuritis; Colchicine; Combined Modality Therapy; Diclofenac; Drug Combinations; Female; Humans; Lidocaine; Male; Middle Aged; Transcutaneous Electric Nerve Stimulation	1991
Conformation of thiocolchicine and two B-ring-modified analogues bound to tubulin studied with optical spectroscopy. Biochemistry, 1991, Feb-05, Volume: 30, Issue:5 Topics: Animals; Cattle; Circular Dichroism; Colchicine; In Vitro Techniques; Magnetic Resonance Spectroscopy; Microtubules; Protein Binding; Spectrophotometry, Ultraviolet; Tubulin	1991
N-acetylcolchinol O-methyl ether and thiocolchicine, potent analogs of colchicine modified in the C ring. Evaluation of the mechanistic basis for their enhanced biological properties. The Journal of biological chemistry, 1990, Jun-25, Volume: 265, Issue:18 Topics: Animals; Binding Sites; Calorimetry; Carbon Radioisotopes; Cattle; Colchicine; Kinetics; Molecular Structure; Radioisotope Dilution Technique; Structure-Activity Relationship; Thermodynamics; Tubulin	1990
Association of thiocolchicine with tubulin. Biochemical and biophysical research communications, 1989, Jun-15, Volume: 161, Issue:2 Topics: Animals; Binding, Competitive; Cattle; Colchicine; In Vitro Techniques; Kinetics; Protein Binding; Spectrometry, Fluorescence; Structure-Activity Relationship; Temperature; Tubulin	1989
Antitumor agents--CLXXV. Anti-tubulin action of (+)-thiocolchicine prepared by partial synthesis. Bioorganic & medicinal chemistry, 1997, Volume: 5, Issue:12 Topics: Antineoplastic Agents; Chromatography, Thin Layer; Colchicine; Humans; Isomerism; Magnetic Resonance Spectroscopy; Models, Chemical; Tubulin Modulators; Tumor Cells, Cultured	1997
Antiproliferative activity of colchicine analogues on MDR-positive and MDR-negative human cancer cell lines. Anti-cancer drug design, 1998, Volume: 13, Issue:1 Topics: Antineoplastic Agents; Cell Cycle; Colchicine; Drug Resistance, Multiple; Fluorine; Growth Inhibitors; Humans; Structure-Activity Relationship; Tumor Cells, Cultured	1998
Interaction of novel thiocolchicine analogs with the tubulin isoforms from bovine brain. Biochemical and biophysical research communications, 1999, Jan-19, Volume: 254, Issue:2 Topics: Animals; Brain; Cattle; Colchicine; Kinetics; Molecular Structure; Protein Isoforms; Spectrometry, Fluorescence; Structure-Activity Relationship; Tryptophan; Tubulin	1999
Biological evaluation on different human cancer cell lines of novel colchicine analogs. Oncology research, 1999, Volume: 11, Issue:3 Topics: Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Cycle; Colchicine; Colonic Neoplasms; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Leukemia; Tubulin; Tumor Cells, Cultured	1999
Novel allocolchicinoids with an eight membered B-ring: design, synthesis and inhibition of tubulin assembly. Bioorganic & medicinal chemistry, 2000, Volume: 8, Issue:3 Topics: Animals; Antineoplastic Agents; Cattle; Colchicine; Lactams; Magnetic Resonance Spectroscopy; Structure-Activity Relationship; Tubulin; Tubulin Modulators	2000
Topical cytotoxic therapy for cutaneous cancer and precancer. Archives of dermatology, 1965, Volume: 92, Issue:3 Topics: Administration, Topical; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Bowen's Disease; Carcinoma, Basal Cell; Colchicine; Demecolcine; Humans; Keratoacanthoma; Methotrexate; Precancerous Conditions; Skin Neoplasms; Triaziquone	1965
Effects of thiocolchicine on axonal cytoskeleton of the rat peroneus nerve. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2002, Volume: 54, Issue:3 Topics: Animals; Axons; Colchicine; Cytoskeleton; Injections, Intraperitoneal; Male; Microtubules; Myelin Sheath; Peroneal Nerve; Rats; Rats, Sprague-Dawley	2002
[Antimitotic activity and toxicity of some derivatives of colchicine and thiocolchicine]. Archives internationales de pharmacodynamie et de therapie, 1955, Oct-01, Volume: 103, Issue:2-3 Topics: Antimitotic Agents; Antineoplastic Agents; Colchicine	1955
[Trial chemotherapy of myeloid leukemia by three new substances: demecolcine, thiocolchicine, myleran]. La Presse medicale, 1955, Sep-21, Volume: 63, Issue:61 Topics: Antineoplastic Agents; Busulfan; Colchicine; Demecolcine; Glycols; Leukemia; Leukemia, Myeloid	1955
[N-desacetyl-thiocolchicine in antitumor chemotherapy]. Acta - Unio Internationalis Contra Cancrum, 1957, Volume: 13, Issue:3 Topics: Colchicine; Leukemia; Leukemia, Myeloid; Neoplasms; Skin Neoplasms	1957
[Effects produced by N-desacetyl-thiocolchicine (R 261) on the hermaphrodite gland of adult Limnaea stagnalis]. Therapie, 1957, Volume: 12, Issue:6 Topics: Animals; Colchicine; Gonads; Lymnaea	1957
[Presentation of some demonstrative evidence on the results of tumor therapy by desoxyribonucleic acid and thiocolchicine; positive balance of desoxyribonucleic acid]. Therapie, 1957, Volume: 12, Issue:6 Topics: Colchicine; DNA; Humans; Neoplasms	1957
[Effects of compound R-875 in very intense local algetic reactions in karyoklastic treatment by thiocolchicine: a case of intolerance with hallucinatory phenomena]. Therapie, 1958, Volume: 13, Issue:6 Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Colchicine; Hallucinations; Humans	1958
[ON THE TERATOGENIC ACTION OF N-DESACETYL-THIOCOLCHICINE ALONE OR COMBINED WITH THYROXIN]. Comptes rendus des seances de la Societe de biologie et de ses filiales, 1963, Aug-31, Volume: 157 Topics: Abnormalities, Drug-Induced; Chick Embryo; Colchicine; Encephalocele; Genetics; Research; Teratogenesis; Teratogens; Thyroxine; Toxicology	1963
[Treatment of primary cancer of the liver by N-desacetyl-thiocolchicine]. Annales de la Societe belge de medecine tropicale (1920), 1961, Oct-31, Volume: 41 Topics: Colchicine; Humans; Liver Neoplasms; Neoplasms	1961
Thiocolchicine dimers: a novel class of topoisomerase-I inhibitors. Biochemical pharmacology, 2005, Jan-01, Volume: 69, Issue:1 Topics: Cell Line; Colchicine; Dimerization; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Topoisomerase I Inhibitors	2005
New synthetic thiocolchicine derivatives as lowtoxic anticancer agents. Archiv der Pharmazie, 2005, Volume: 338, Issue:12 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; CHO Cells; Colchicine; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Humans; Inhibitory Concentration 50	2005
Thiocolchicine-podophyllotoxin conjugates: dynamic libraries based on disulfide exchange reaction. The Journal of organic chemistry, 2006, Mar-31, Volume: 71, Issue:7 Topics: Cell Line, Tumor; Cell Proliferation; Chromatography, High Pressure Liquid; Colchicine; Combinatorial Chemistry Techniques; Disulfides; Drug Screening Assays, Antitumor; Humans; In Vitro Techniques; Molecular Conformation; Podophyllotoxin; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism	2006
Synthesis and biological evaluation of paclitaxel-thiocolchicine hybrids. Chemistry & biodiversity, 2004, Volume: 1, Issue:2 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cattle; Cell Line, Tumor; Colchicine; Drug Screening Assays, Antitumor; Humans; Microtubules; Paclitaxel	2004
Synthesis and antitumor activity of nitrogen-based thiocolchicine derivatives. Yao xue xue bao = Acta pharmaceutica Sinica, 2006, Volume: 41, Issue:11 Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Survival; Colchicine; Humans; Inhibitory Concentration 50; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred ICR; Models, Chemical; Molecular Structure; Neoplasm Transplantation; Prostatic Neoplasms; Structure-Activity Relationship	2006
Inhibitors of tubulin polymerization: synthesis and biological evaluation of hybrids of vindoline, anhydrovinblastine and vinorelbine with thiocolchicine, podophyllotoxin and baccatin III. Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11 Topics: Alkaloids; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Colchicine; Combinatorial Chemistry Techniques; Dimerization; Drug Design; Humans; Podophyllotoxin; Radiation-Sensitizing Agents; Swine; Taxoids; Tubulin; Tubulin Modulators; Vinblastine; Vinorelbine	2008
Synthesis and biological evaluation of novel thiocolchicine-podophyllotoxin conjugates. European journal of medicinal chemistry, 2010, Volume: 45, Issue:1 Topics: Animals; Cattle; Cell Line, Tumor; Colchicine; Fluorescent Antibody Technique; Glutathione; Humans; Inhibitory Concentration 50; Mice; Podophyllotoxin; Protein Multimerization; Protein Structure, Quaternary; Tubulin	2010
Derivatives of thiocolchicine and its applications to CEM cells treatment using 19F magnetic resonance ex vivo. Bioorganic chemistry, 2010, Volume: 38, Issue:1 Topics: Bioreactors; Cells, Cultured; Chromatography, High Pressure Liquid; Colchicine; Fluorine; Humans; Magnetic Resonance Imaging; Mass Spectrometry; Spectrophotometry, Ultraviolet; T-Lymphocytes	2010
Biotransformation of colchicinoids into their corresponding 3-O-glucosyl derivatives by selected strains of Bacillus megaterium. Molecular biotechnology, 2014, Volume: 56, Issue:7 Topics: Anti-Inflammatory Agents; Bacillus megaterium; Biotransformation; Colchicine; Humans; Muscle, Skeletal	2014
A Novel Microtubule-Disrupting Agent Induces Endoplasmic Reticular Stress-Mediated Cell Death in Human Hepatocellular Carcinoma Cells. PloS one, 2015, Volume: 10, Issue:9 Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Caspases; Cell Death; Colchicine; Dose-Response Relationship, Drug; Endoplasmic Reticulum Stress; Enzyme Activation; G2 Phase Cell Cycle Checkpoints; Hep G2 Cells; Humans; Inhibitory Concentration 50; Liver Neoplasms; Membrane Potential, Mitochondrial; Mice, Inbred BALB C; Mice, Nude; Microtubules; Molecular Chaperones; Signal Transduction; Time Factors	2015
Synthesis, antiproliferative activity and molecular docking of thiocolchicine urethanes. Bioorganic chemistry, 2018, Volume: 81 Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Colchicine; Drug Design; Drug Screening Assays, Antitumor; Humans; Mitosis; Models, Molecular; Molecular Docking Simulation; Neoplasms; Tubulin; Tubulin Modulators; Urethane	2018
Synthesis, antiproliferative activity, and molecular docking studies of 4-chlorothiocolchicine analogues. Chemical biology & drug design, 2020, Volume: 95, Issue:1 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cisplatin; Colchicine; Doxorubicin; Drug Screening Assays, Antitumor; Humans; Mice; Molecular Docking Simulation; Protein Conformation; Thermodynamics; Tubulin; Tubulin Modulators	2020
Synthesis of Thicolchicine-Based Conjugates: Investigation towards Bivalent Tubulin/Microtubules Binders. ChemPlusChem, 2019, Volume: 84, Issue:1 Topics: Antineoplastic Agents; Binding Sites; Cell Line, Tumor; Cell Proliferation; Colchicine; Humans; Ligands; Molecular Dynamics Simulation; Stereoisomerism; Tubulin	2019
Synthesis, biological evaluation and molecular docking studies of new amides of 4-chlorothiocolchicine as anticancer agents. Bioorganic chemistry, 2020, Volume: 97 Topics: Amides; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Colchicine; Drug Design; Drug Screening Assays, Antitumor; Halogenation; Humans; Molecular Docking Simulation; Neoplasms; Tubulin Modulators	2020
Synthesis and Antiproliferative Screening Of Novel Analogs of Regioselectively Demethylated Colchicine and Thiocolchicine. Molecules (Basel, Switzerland), 2020, Mar-05, Volume: 25, Issue:5 Topics: Antimitotic Agents; Chemical Phenomena; Chemistry Techniques, Synthetic; Colchicine; Demethylation; Dose-Response Relationship, Drug; Molecular Conformation; Molecular Structure; Spectrum Analysis; Structure-Activity Relationship	2020