thiazoles has been researched along with z 338 in 73 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (13.70) | 29.6817 |
| 2010's | 54 (73.97) | 24.3611 |
| 2020's | 9 (12.33) | 2.80 |
| Authors | Studies |
|---|---|
| Kaibara, M; Kurimoto, T; Ogishima, M; Taniyama, K; Ueki, S | 1 |
| Ito, Y; Nakajima, T; Nawata, H | 1 |
| Furuta, S; Miyahara, H; Sano, H; Sugimoto, T | 1 |
| Akaike, N; Doi, A; Ishibashi, H; Ito, Y; Kanemoto, Y | 1 |
| Abe, K; Inoue, R; Ito, Y; Morita, H | 1 |
| Lehmann, A | 1 |
| Furuta, S; Kamada, E; Kawabata, Y; Kurimoto, T; Omata, T; Sugimoto, T; Wu, XC; Yonezawa, K | 1 |
| Doi, Y; Hayashi, H; Kaibara, M; Murasaki, O; Taniyama, K; Uezono, Y; Yano, K | 1 |
| Katsunuma, K; Kobayashi, N; Sasaki, T; Seto, K; Tack, J; Tanaka, K | 1 |
| Berstad, A; Heading, R; Kato, H; Masclee, A; Piessevaux, H; Popiela, T; Tack, J; Vandenberghe, A | 1 |
| Aoki, H; Hongo, M; Kato, H; Matsueda, K; Saito, Y; Tack, J | 1 |
| Akaike, H; Akaike, N; Hori, N; Ito, Y; Jang, II; Ogawa, S | 1 |
| Hibi, T; Suzuki, H | 1 |
| Eta, R; Furuta, S; Hori, Y; Itoh, Z; Kawabata, Y; Matsumura, T; Matsunaga, Y; Tack, J; Takei, M; Tanaka, T; Ueki, S; Yoshida, K; Yoshii, K; Yoshinaga, K | 1 |
| Janssen, P; Tack, J | 1 |
| Hasegawa, J; Hirayama, M; Kawabata, Y; Mera, Y; Nakamura, T; Takei, M; Toda, R; Yoshii, K | 1 |
| Hirayama, M; Hori, Y; Inoue, N; Ito, K; Kawabata, Y; Kawachi, M; Matsunaga, Y; Nagahama, K; Ozaki, T; Takei, M; Tanaka, T; Toda, R; Yoshii, K | 1 |
| Akiho, H; Hongo, M; Matsueda, K; Ushijima, S | 1 |
| Hongo, M; Kato, H; Matsueda, K; Saito, Y; Tack, J | 1 |
| Bytzer, P | 1 |
| Haruma, K; Hata, J; Imamura, H; Kamada, T; Kato, H; Kusunoki, H; Manabe, N; Saito, Y; Shiotani, A; Sugioka, H; Tack, J | 1 |
| Hori, Y; Ito, K; Kawachi, M; Matsunaga, Y; Nagahama, K; Oka, H; Takei, M; Tanaka, T | 1 |
| Altan, E; Farré, R; Masaoka, T; Tack, J | 1 |
| Leake, I | 1 |
| Nolan, ML; Nowlan, ML; Scott, LJ | 1 |
| Ford, AC; Moayyedi, P | 1 |
| Kato, H; Matsunaga, Y; Saito, Y; Takei, M; Tanaka, T | 1 |
| McCallum, RW; Song, G; Sun, Y | 1 |
| Miwa, H; Oshima, T | 1 |
| Deng, J; Fan, J; Guo, Q; Tan, S; Wan, C; Xiao, G; Xie, X; Zhu, Y | 1 |
| Kato, H; Kusano, M; Matsueda, K; Saito, Y; Urita, Y; Zai, H | 1 |
| Kishino, M; Kitagawa, Y; Mayanagi, S; Sunamura, M | 1 |
| Talley, NJ; Walker, MM; Zala, AV | 1 |
| Gananadhamu, S; Kalariya, PD; Patel, PN; Srinivas, R; Swamy, CV | 1 |
| Eguchi, T; Fujita, M; Fukuchi, T; Iwatsubo, T; Kanamori, A; Koizumi, A; Koyama, S; Okada, A; Tsujimae, M; Ubukata, S; Yamashita, H | 1 |
| Hirayama, M; Iikura, M; Kawabata, Y; Toda, R; Yoshii, K | 1 |
| Aimi, M; Ishihara, S; Ishimura, N; Kinoshita, Y; Mikami, H; Mori, M; Oshima, N; Shimura, S; Uno, G | 1 |
| Hirayama, M; Hori, Y; Ito, K; Kawabata, Y; Kawachi, M; Matsunaga, Y; Nagahama, K; Ozaki, T; Shiraishi, Y; Takei, M; Tanaka, T | 1 |
| Chiba, K; Hirayama, M; Kawabata, Y; Kinomoto, T; Toda, R; Yamaguchi, T; Yoshii, K | 1 |
| Masaoka, T; Matsushita, M; Suzuki, H | 1 |
| Akamizu, T; Futagami, S; Gudis, K; Hashimoto, S; Iwakiri, K; Kawagoe, T; Kodaka, Y; Maruki, Y; Nagoya, H; Sakamoto, C; Sato, H; Yamawaki, H | 1 |
| Huang, R; Li, J; Qu, H; Sun, M; Wang, Z; Zhao, Z | 1 |
| He, J; Huang, Y; Li, H; Ma, X; Wang, Q | 1 |
| Fukaura, K; Ihara, E; Muta, K; Nakamura, K; Ochiai, T; Tsuchida, O | 1 |
| Asano, H; Fukui, H; Hirota, S; Kazuhito, F; Kondo, T; Kono, T; Miwa, H; Nakamura, K; Ohda, Y; Okugawa, T; Oshima, T; Tomita, T; Tozawa, K; Watari, J; Yamasaki, T | 1 |
| Hayashi, Y; Kawarai Lefor, A; Osawa, H; Sakamoto, H; Shinozaki, S; Yamamoto, H | 1 |
| Fukui, H; Ikeo, K; Kondo, T; Miwa, H; Oshima, T; Sei, H; Watari, J | 1 |
| Gananadhamu, S; Kalariya, PD; Patel, PN; Srinivas, R; Thummar, M | 1 |
| Fukaura, K; Ihara, E; Muta, K; Nakamura, K | 1 |
| Asaoka, D; Hojo, M; Izumi, K; Matsumoto, K; Nagahara, A; Nojiri, S; Shimada, Y; Takeda, T; Ueyama, H; Watanabe, S | 1 |
| Baik, GH; Bang, CS; Kim, DJ; Park, TY; Shin, SP; Suk, KT; Yang, YJ | 1 |
| Harada, S; Higashino, T; Higuchi, K; Hoshimoto, M; Itabashi, T; Kawaguchi, S; Kojima, K; Kojima, Y; Kuramoto, T; Kusano, M; Ota, K; Sakaguchi, M; Sakamoto, H; Sanomura, M; Takada, K; Takahashi, Y; Takeuchi, T; Tominaga, K | 1 |
| Abe, K; Aoyagi, H; Isono, A; Kita, H; Maruyama, K; Miki, A; Nakamura, N; Yamamoto, T | 1 |
| Hayashi, Y; Lefor, AK; Miura, Y; Osawa, H; Sakamoto, H; Shinozaki, S; Yamamoto, H | 1 |
| Banciu, C; Bunganic, I; Eavis, P; Kleban, Y; Miyagawa, T; Pokrotnieks, J; Tack, J; Törnblom, H; Tsuchikawa, M; Urbonas, G; Yakusevich, V | 1 |
| Attia, KAM; El-Olemy, A; Nassar, MWI; Ramzy, S | 1 |
| Kawabata, Y; Kawabe, M; Kinomoto, T; Kuroda, H; Ogawa, S; Oishi, Y; Suguro, M | 1 |
| Bollegala, NP; Khanna, R; Leontiadis, GI; Moayyedi, P; Pittayanon, R; Yuan, Y | 1 |
| Acharya, S; Mehta, SC; Muni, SK; Porika, SK; Sharma, AD; Veligandla, KC | 1 |
| Agawa, S; Futagami, S; Gudis, K; Higuchi, K; Iwakiri, K; Kaneko, K; Kawamoto, C; Kodaka, Y; Murakami, M; Sakasegawa, N; Ueki, N; Wakabayashi, M; Yamawaki, H | 1 |
| Hongoh, M; Kinoshita, Y; Naora, K; Okada, A; Yamashita, H | 1 |
| Carbone, F; Masuy, I; Tack, J; Verbeke, K | 1 |
| Amano, S; Aoyama, T; Hayashi, T; Kano, K; Maezawa, Y; Masuda, M; Morita, J; Numata, M; Ohshima, T; Rino, Y; Sato, T; Sawazaki, S; Yamada, T; Yoshikawa, T; Yukawa, N | 1 |
| Hayashi, Y; Kobayashi, Y; Lefor, AK; Miura, Y; Osawa, H; Sakamoto, H; Shinozaki, S; Yamamoto, H | 1 |
| Akiyama, T; Matsumura, N; Minami, T; Sugimoto, K; Uejima, S; Uemura, H | 1 |
| Ebi, M; Funaki, Y; Izawa, S; Kasugai, K; Kawamura, Y; Ogasawara, N; Sasaki, M; Tamura, Y; Yoshimine, T | 1 |
| Carbone, F; Masuy, I; Schol, J; Tack, J; Van den Houte, K; Vandenberghe, A | 1 |
| Agawa, S; Futagami, S; Gudis, K; Higuchi, K; Ikeda, G; Iwakiri, K; Kirita, K; Kodaka, Y; Murakami, M; Noda, H; Sakasegawa, N; Ueki, N; Yamawaki, H | 1 |
| Hirayama, M; Hoshino, Y; Kawabata, Y; Nakanishi, T; Tamai, I; Toda, R; Yoshii, K | 1 |
| Chermansky, C; Ikeda, Y; Kanai, A; Mizoguchi, S; Singh, N; Suzuki, T; Tyagi, P; Yoshimura, N; Zabbarova, I | 1 |
| Hashimoto, K; Horie, S; Imai, T; Matsumoto, K; Tashima, K | 1 |
| Bai, X; Chinen, T; Esaki, M; Hamada, S; Hata, Y; Ihara, E; Ikeda, H; Minoda, Y; Muta, K; Ogawa, Y; Ogino, H; Tanaka, Y; Wada, M | 1 |
| Abdelazim, AH; Ramzy, S; Shahin, M | 1 |
13 review(s) available for thiazoles and z 338
| Article | Year |
|---|---|
Acotiamide (Z-338) as a possible candidate for the treatment of functional dyspepsia.
Topics: Animals; Benzamides; Dyspepsia; Humans; Randomized Controlled Trials as Topic; Thiazoles | 2010 |
Acotiamide (Z-338, YM443), a new drug for the treatment of functional dyspepsia.
Topics: Animals; Benzamides; Clinical Trials as Topic; Dyspepsia; Gastric Emptying; Humans; Stomach; Thiazoles | 2011 |
Acotiamide, a novel gastroprokinetic for the treatment of patients with functional dyspepsia: postprandial distress syndrome.
Topics: Animals; Benzamides; Clinical Trials as Topic; Dyspepsia; Humans; Postprandial Period; Thiazoles; Treatment Outcome | 2012 |
Dyspepsia.
Topics: Antidepressive Agents, Tricyclic; Benzamides; Diet; Dyspepsia; Gastroesophageal Reflux; Gastrointestinal Agents; Humans; Peptic Ulcer; Probiotics; Thiazoles | 2013 |
[Pharmacological and clinical profile of acotiamide hydrochloride hydrate (Acofide(®) Tablets 100 mg), a novel therapeutic agent for functional dyspepsia (FD)].
Topics: Administration, Oral; Animals; Benzamides; Cholinesterase Inhibitors; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Disease Models, Animal; Dyspepsia; Gastric Emptying; Gastrointestinal Motility; Humans; Tablets; Thiazoles; Treatment Outcome | 2014 |
Evaluation of acotiamide for the treatment of functional dyspepsia.
Topics: Animals; Benzamides; Clinical Trials as Topic; Drug Approval; Drug Design; Dyspepsia; Humans; Japan; Postprandial Period; Thiazoles | 2014 |
Efficacy and safety of acotiamide for the treatment of functional dyspepsia: systematic review and meta-analysis.
Topics: Benzamides; Dose-Response Relationship, Drug; Dyspepsia; Humans; Odds Ratio; Randomized Controlled Trials as Topic; Thiazoles | 2014 |
Emerging drugs for functional dyspepsia.
Topics: Benzamides; Drug Design; Dyspepsia; Gastrointestinal Agents; Helicobacter Infections; Helicobacter pylori; Humans; Postprandial Period; Proton Pump Inhibitors; Thiazoles | 2015 |
Emerging treatments in neurogastroenterology: Acotiamade, a novel treatment option for functional dyspepsia.
Topics: Benzamides; Cholinesterase Inhibitors; Dyspepsia; Gastroenterology; Gastrointestinal Agents; Humans; Postprandial Period; Randomized Controlled Trials as Topic; Thiazoles; Treatment Outcome | 2016 |
Diagnosis and Treatment Strategy of Achalasia Subtypes and Esophagogastric Junction Outflow Obstruction Based on High-Resolution Manometry.
Topics: Benzamides; Calcium Channel Blockers; Dilatation; Diltiazem; Esophageal Achalasia; Esophageal Diseases; Esophagogastric Junction; Esophagoscopy; Humans; Laparoscopy; Manometry; Thiazoles | 2017 |
Prokinetics for the treatment of functional dyspepsia: Bayesian network meta-analysis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antiemetics; Bayes Theorem; Benzamides; Benzyl Compounds; Comparative Effectiveness Research; Domperidone; Dyspepsia; Female; Gastrointestinal Agents; Humans; Male; Metoclopramide; Middle Aged; Morpholines; Network Meta-Analysis; Odds Ratio; Randomized Controlled Trials as Topic; Thiazoles; Treatment Outcome; Trimebutine; Young Adult | 2017 |
Prokinetics for functional dyspepsia.
Topics: Benzamides; Benzyl Compounds; Cisapride; Domperidone; Dyspepsia; Erythromycin; Gastrointestinal Agents; Humans; Indoles; Morpholines; Numbers Needed To Treat; Quality of Life; Randomized Controlled Trials as Topic; Thiazoles | 2018 |
Current and emerging therapeutic options for the management of functional dyspepsia.
Topics: Abdominal Pain; Benzamides; Dyspepsia; Humans; Postprandial Period; Syndrome; Thiazoles | 2020 |
16 trial(s) available for thiazoles and z 338
| Article | Year |
|---|---|
A dose-ranging, placebo-controlled, pilot trial of Acotiamide in patients with functional dyspepsia.
Topics: Adolescent; Adult; Aged; Benzamides; Breath Tests; Dose-Response Relationship, Drug; Double-Blind Method; Dyspepsia; Female; Gastric Emptying; Gastrointestinal Agents; Humans; Male; Middle Aged; Pilot Projects; Placebos; Quality of Life; Thiazoles; Young Adult | 2009 |
Clinical trial: dose-dependent therapeutic efficacy of acotiamide hydrochloride (Z-338) in patients with functional dyspepsia - 100 mg t.i.d. is an optimal dosage.
Topics: Adult; Aged; Benzamides; Dose-Response Relationship, Drug; Double-Blind Method; Dyspepsia; Eating; Endpoint Determination; Female; Gastric Emptying; Humans; Male; Middle Aged; Patient Compliance; Satiety Response; Thiazoles; Young Adult | 2010 |
A long-term study of acotiamide in patients with functional dyspepsia: results from an open-label phase III trial in Japan on efficacy, safety and pattern of administration.
Topics: Abdominal Pain; Adult; Benzamides; Dyspepsia; Female; Humans; Male; Middle Aged; Muscarinic Agonists; Postprandial Period; Satiation; Sensation; Thiazoles; Time Factors; Treatment Outcome; Young Adult | 2011 |
A placebo-controlled trial of acotiamide for meal-related symptoms of functional dyspepsia.
Topics: Adult; Benzamides; Cholinesterase Inhibitors; Double-Blind Method; Dyspepsia; Eating; Female; Humans; Male; Postprandial Period; Thiazoles; Time Factors; Treatment Outcome | 2012 |
Therapeutic efficacy of acotiamide in patients with functional dyspepsia based on enhanced postprandial gastric accommodation and emptying: randomized controlled study evaluation by real-time ultrasonography.
Topics: Adult; Aged; Benzamides; Double-Blind Method; Dyspepsia; Female; Gastric Emptying; Gastrointestinal Motility; Humans; Male; Middle Aged; Postprandial Period; Stomach; Supine Position; Thiazoles; Treatment Outcome; Ultrasonography | 2012 |
Effect of acotiamide on gastric emptying in healthy adult humans.
Topics: Adult; Analysis of Variance; Benzamides; Cross-Over Studies; Double-Blind Method; Gastric Emptying; Healthy Volunteers; Humans; Male; Muscarinic Antagonists; Thiazoles; Young Adult | 2014 |
Efficacy of acotiamide in combination with esomeprazole for functional dyspepsia refractory to proton-pump inhibitor monotherapy.
Topics: Benzamides; Drug Resistance; Drug Therapy, Combination; Dyspepsia; Esomeprazole; Female; Gastroesophageal Reflux; Humans; Male; Middle Aged; Proton Pump Inhibitors; Thiazoles; Treatment Outcome | 2014 |
Novel Prokinetic Acotiamide Reduces Transient Lower Esophageal Sphincter Relaxation in Healthy Subjects.
Topics: Adult; Benzamides; Electric Impedance; Esophageal Sphincter, Lower; Female; Gastroesophageal Reflux; Gastrointestinal Agents; Gastrointestinal Motility; Healthy Volunteers; Humans; Hydrogen-Ion Concentration; Male; Manometry; Muscle Relaxation; Thiazoles | 2015 |
Improvement of meal-related symptoms and epigastric pain in patients with functional dyspepsia treated with acotiamide was associated with acylated ghrelin levels in Japan.
Topics: Abdominal Pain; Acylation; Adolescent; Adult; Aged; Aged, 80 and over; Benzamides; Biomarkers; Drug Therapy, Combination; Dyspepsia; Female; Gastrointestinal Agents; Ghrelin; Humans; Japan; Male; Meals; Middle Aged; Postprandial Period; Prospective Studies; Rabeprazole; Thiazoles; Treatment Outcome; Young Adult | 2016 |
A double-blind placebo controlled study of acotiamide hydrochloride for efficacy on gastrointestinal motility of patients with functional dyspepsia.
Topics: Adult; Aged; Anxiety; Benzamides; Double-Blind Method; Dyspepsia; Female; Gastric Emptying; Gastrointestinal Motility; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Psychometrics; Quality of Life; Radionuclide Imaging; Severity of Illness Index; Stomach; Thiazoles; Treatment Outcome | 2017 |
A Randomized, Double-Blind, Pilot Study of the Effect of Famotidine on Acotiamide Treatment for Functional Dyspepsia.
Topics: Abdominal Pain; Adult; Benzamides; Cholinesterase Inhibitors; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Dyspepsia; Famotidine; Female; Histamine H2 Antagonists; Humans; Male; Middle Aged; Pilot Projects; Placebos; Postprandial Period; Proton Pump Inhibitors; Quality of Life; Thiazoles; Treatment Outcome | 2017 |
Therapy of gastroesophageal reflux disease and functional dyspepsia overlaps with symptoms after usual-dose proton pump inhibitor: Acotiamide plus usual-dose proton pump inhibitor versus double-dose proton pump inhibitor.
Topics: Aged; Benzamides; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Dyspepsia; Female; Gastroesophageal Reflux; Humans; Male; Middle Aged; Proton Pump Inhibitors; Rabeprazole; Surveys and Questionnaires; Thiazoles; Time Factors; Treatment Outcome | 2018 |
Long-term safety and efficacy of acotiamide in functional dyspepsia (postprandial distress syndrome)-results from the European phase 3 open-label safety trial.
Topics: Adult; Benzamides; Dyspepsia; Europe; Female; Gastrointestinal Agents; Humans; Male; Middle Aged; Postprandial Period; Thiazoles; Time Factors; Treatment Outcome | 2018 |
Adding Acotiamide to Gastric Acid Inhibitors Is Effective for Treating Refractory Symptoms in Patients with Non-erosive Reflux Disease.
Topics: Adult; Aged; Aged, 80 and over; Benzamides; Double-Blind Method; Drug Therapy, Combination; Esophageal pH Monitoring; Esophagitis, Peptic; Female; Gastroesophageal Reflux; Humans; Japan; Male; Manometry; Middle Aged; Prospective Studies; Proton Pump Inhibitors; Remission Induction; Thiazoles; Time Factors; Treatment Outcome; Young Adult | 2019 |
Acotiamide affects antral motility, but has no effect on fundic motility, gastric emptying or symptom perception in healthy participants.
Topics: Adult; Benzamides; Cross-Over Studies; Female; Gastric Emptying; Gastric Fundus; Gastrointestinal Agents; Gastrointestinal Motility; Healthy Volunteers; Humans; Male; Manometry; Pyloric Antrum; Single-Blind Method; Thiazoles; Young Adult | 2019 |
Effects of acotiamide on functional dyspepsia patients with heartburn who failed proton pump inhibitor treatment in Japanese patients: A randomized, double-blind, placebo-controlled crossover study.
Topics: Adult; Aged; Asian People; Benzamides; Cross-Over Studies; Double-Blind Method; Dyspepsia; Female; Gastrointestinal Agents; Gastrointestinal Diseases; Humans; Male; Middle Aged; Thiazoles | 2020 |
44 other study(ies) available for thiazoles and z 338
| Article | Year |
|---|---|
Z-338 facilitates acetylcholine release from enteric neurons due to blockade of muscarinic autoreceptors in guinea pig stomach.
Topics: Acetylcholine; Animals; Autoreceptors; Benzamides; Gastrointestinal Agents; Guinea Pigs; In Vitro Techniques; Male; Muscarinic Antagonists; Muscle Contraction; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptors, Muscarinic; Stomach; Thiazoles; Xenopus | 2000 |
Z-338, a newly synthetized carboxyamide derivative, stimulates gastric motility through enhancing the excitatory neurotransmission.
Topics: Animals; Benzamides; Gastrointestinal Agents; Gastrointestinal Motility; Guinea Pigs; Male; Muscle Contraction; Muscle, Smooth; Stomach; Thiazoles | 2000 |
LC determination of Z-338, novel gastroprokinetic agent in dog plasma by SCX solid phase extraction.
Topics: Animals; Benzamides; Chromatography, High Pressure Liquid; Dogs; Gastrointestinal Agents; Male; Thiazoles | 2001 |
An electrophysiological study of muscarinic and nicotinic receptors of rat paratracheal ganglion neurons and their inhibition by Z-338.
Topics: Animals; Benzamides; Dose-Response Relationship, Drug; Electrophysiology; Ganglia, Sensory; Gastrointestinal Agents; Membrane Potentials; Neurons; Rats; Rats, Wistar; Receptors, Muscarinic; Receptors, Nicotinic; Thiazoles; Trachea | 2002 |
Possible involvement of M5 muscarinic receptor in the enhancing actions of the novel gastroprokinetic agent Z-338 on nifedipine-sensitive voltage-dependent Ca2+ currents in guinea pig stomach.
Topics: Animals; Benzamides; Calcium Channel Blockers; Calcium Channels, L-Type; Dose-Response Relationship, Drug; Drug Synergism; Female; Gastrointestinal Agents; Guinea Pigs; Male; Membrane Potentials; Nifedipine; Receptor, Muscarinic M5; Receptors, Muscarinic; Stomach; Thiazoles | 2002 |
Z-338. Zeria/Yamanouchi.
Topics: Animals; Benzamides; Biological Availability; Cholinesterase Inhibitors; Clinical Trials, Phase II as Topic; Dogs; Drug Administration Routes; Drug Evaluation, Preclinical; Drug Industry; Drugs, Investigational; Dyspepsia; Gastrointestinal Agents; Gastrointestinal Diseases; Gastrointestinal Motility; Guinea Pigs; Humans; Hypnotics and Sedatives; Molecular Structure; Multicenter Studies as Topic; Rats; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Sweden; Thiazoles; Xenopus | 2004 |
Drug-drug interactions of Z-338, a novel gastroprokinetic agent, with terfenadine, comparison with cisapride, and involvement of UGT1A9 and 1A8 in the human metabolism of Z-338.
Topics: Benzamides; Cell Line; Cisapride; Dose-Response Relationship, Drug; Drug Interactions; Gastrointestinal Agents; Glucuronosyltransferase; Humans; Male; Microsomes, Liver; Terfenadine; Thiazoles; UDP-Glucuronosyltransferase 1A9 | 2004 |
Characterization of functional effects of Z-338, a novel gastroprokinetic agent, on the muscarinic M1, M2, and M3 receptors expressed in Xenopus oocytes.
Topics: Acetylcholine; Animals; Benzamides; Dose-Response Relationship, Drug; Female; Gastrointestinal Agents; Gene Expression; Humans; Membrane Potentials; Muscarinic Antagonists; Oocytes; Piperidines; Pirenzepine; Potassium; Rats; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Reproducibility of Results; Thiazoles; Xenopus | 2004 |
Acotiamide hydrochloride (Z-338), a novel prokinetic agent, restores delayed gastric emptying and feeding inhibition induced by restraint stress in rats.
Topics: Animals; Benzamides; Corticotropin-Releasing Hormone; Feeding Behavior; Gastric Emptying; Gene Expression Profiling; Hypothalamus; Male; Medulla Oblongata; Neuropeptides; Oligonucleotide Array Sequence Analysis; Rats; Rats, Wistar; Restraint, Physical; Stress, Psychological; Thiazoles | 2008 |
Effects of Z-338, a novel gastroprokinetic agent, on the actions of excitatory and inhibitory neurotransmitters on neurons in area postrema.
Topics: Adenosine Triphosphate; Animals; Area Postrema; Benzamides; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Ganglionic Stimulants; Gastrointestinal Agents; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Kainic Acid; Male; N-Methylaspartate; Neurons; Nicotine; Patch-Clamp Techniques; Rats; Rats, Wistar; Thiazoles; Vagus Nerve | 2010 |
Acotiamide hydrochloride (Z-338), a new selective acetylcholinesterase inhibitor, enhances gastric motility without prolonging QT interval in dogs: comparison with cisapride, itopride, and mosapride.
Topics: Animals; Benzamides; Benzyl Compounds; CHO Cells; Cholinesterase Inhibitors; Cisapride; Cricetinae; Cricetulus; Dogs; Gastrointestinal Motility; Guinea Pigs; Heart Conduction System; Humans; Male; Morpholines; Thiazoles | 2011 |
Mechanism for distribution of acotiamide, a novel gastroprokinetic agent for the treatment of functional dyspepsia, in rat stomach.
Topics: Animals; Benzamides; Chromatography, Liquid; Dyspepsia; Gastric Mucosa; Gastrointestinal Agents; Male; Muscle, Skeletal; Protein Binding; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Thiazoles; Tissue Distribution | 2011 |
Acotiamide hydrochloride (Z-338) enhances gastric motility and emptying by inhibiting acetylcholinesterase activity in rats.
Topics: Acetylcholinesterase; Animals; Benzamides; Cholinesterase Inhibitors; Clonidine; Electric Stimulation; Gastric Emptying; Male; Muscle Contraction; Rats; Rats, Sprague-Dawley; Stomach; Thiazoles | 2011 |
New hope for functional dyspepsia?
Topics: Benzamides; Cholinesterase Inhibitors; Dyspepsia; Female; Humans; Male; Thiazoles | 2012 |
Acotiamide, a new orally active acetylcholinesterase inhibitor, stimulates gastrointestinal motor activity in conscious dogs.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Benzamides; Cholinesterase Inhibitors; Clonidine; Dogs; Gastric Emptying; Gastrointestinal Motility; Gastrointestinal Tract; Male; Thiazoles | 2012 |
Functional dyspepsia: Glimmers of hope for functional dyspepsia.
Topics: Benzamides; Diet; Disease Management; Dyspepsia; Helicobacter Infections; Humans; Life Style; Psychology; Thiazoles | 2013 |
Acotiamide: first global approval.
Topics: Benzamides; Drug Approval; Dyspepsia; Gastrointestinal Agents; Gastrointestinal Motility; Humans; Muscarinic Antagonists; Randomized Controlled Trials as Topic; Thiazoles | 2013 |
[Gastrointestinal motility disorders of functional dyspepsia].
Topics: Benzamides; Dyspepsia; Eating; Gastrointestinal Motility; Humans; Thiazoles | 2014 |
Quantitation of acotiamide in rat plasma by UHPLC-Q-TOF-MS: method development, validation and application to pharmacokinetics.
Topics: Animals; Benzamides; Chromatography, High Pressure Liquid; Drug Stability; Linear Models; Male; Mass Spectrometry; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Thiazoles | 2016 |
Physiologically-Based Pharmacokinetic and Pharmacodynamic Modeling for the Inhibition of Acetylcholinesterase by Acotiamide, A Novel Gastroprokinetic Agent for the Treatment of Functional Dyspepsia, in Rat Stomach.
Topics: Acetylcholinesterase; Animals; Benzamides; Cholinesterase Inhibitors; Dyspepsia; Gastric Emptying; Gastric Mucosa; Male; Rats; Rats, Sprague-Dawley; Stomach; Thiazoles | 2016 |
Effects of acotiamide on esophageal motor function and gastroesophageal reflux in healthy volunteers.
Topics: Adult; Benzamides; Cross-Over Studies; Electric Impedance; Esophageal pH Monitoring; Esophageal Sphincter, Lower; Female; Gastroesophageal Reflux; Gastrointestinal Agents; Healthy Volunteers; Humans; Male; Manometry; Peristalsis; Postprandial Period; Thiazoles; Young Adult | 2015 |
Acotiamide Hydrochloride, a Therapeutic Agent for Functional Dyspepsia, Enhances Acetylcholine-induced Contraction via Inhibition of Acetylcholinesterase Activity in Circular Muscle Strips of Guinea Pig Stomach.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Benzamides; Benzyl Compounds; Carbachol; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Dyspepsia; Guinea Pigs; In Vitro Techniques; Male; Morpholines; Muscle Contraction; Muscle, Smooth; Neostigmine; Stomach; Thiazoles | 2016 |
Distribution of acotiamide, an orally active acetylcholinesterase inhibitor, into the myenteric plexus of rat and dog stomachs.
Topics: Acetylcholinesterase; Animals; Benzamides; Cholinesterase Inhibitors; Dogs; Dyspepsia; Gastric Mucosa; Male; Myenteric Plexus; Rats; Rats, Sprague-Dawley; Stomach; Thiazoles | 2016 |
Development and Validation of a Sensitive and Specific LC-MS-MS Method for the Determination of Acotiamide in Rat Plasma.
Topics: Animals; Benzamides; Blood Chemical Analysis; Chromatography, Liquid; Limit of Detection; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tandem Mass Spectrometry; Thiazoles | 2016 |
Probing the Interaction between Acotiamide Hydrochloride and Pepsin by Multispectral Methods, Electrochemical Measurements, and Docking Studies.
Topics: Animals; Benzamides; Binding Sites; Circular Dichroism; Electrochemical Techniques; Hydrogen Bonding; Molecular Docking Simulation; Pepsin A; Protein Binding; Protein Domains; Protein Structure, Secondary; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Swine; Thermodynamics; Thiazoles | 2016 |
Effects of Acotiamide on the Esophageal Motility Function in Patients with Esophageal Motility Disorders: A Pilot Study.
Topics: Adult; Aged; Aged, 80 and over; Benzamides; Dyspepsia; Esophageal Motility Disorders; Esophageal Sphincter, Lower; Female; Gastrointestinal Agents; Gastrointestinal Motility; Humans; Japan; Male; Manometry; Middle Aged; Pilot Projects; Single-Blind Method; Thiazoles | 2016 |
The effect of acotiamide on epigastric pain syndrome and postprandial distress syndrome in patients with functional dyspepsia.
Topics: Abdominal Pain; Adult; Aged; Benzamides; Dyspepsia; Female; Gastroesophageal Reflux; Humans; Male; Middle Aged; Postprandial Period; Quality of Life; Retrospective Studies; Syndrome; Thiazoles | 2016 |
Acotiamide improves stress-induced impaired gastric accommodation.
Topics: Animals; Benzamides; Gastric Emptying; Gastrointestinal Agents; Guinea Pigs; Male; Stomach; Stress, Psychological; Thiazoles | 2017 |
In vivo metabolite identification of acotiamide in rats using ultra-performance liquid chromatography-quadrupole/time-of-flight mass spectrometry.
Topics: Animals; Benzamides; Chromatography, Liquid; Male; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Thiazoles | 2017 |
Extensive gastric mucosal atrophy is a possible predictor of clinical effectiveness of acotiamide in patients with functional dyspepsia
.
Topics: Adult; Aged; Atrophy; Benzamides; Dyspepsia; Female; Gastric Mucosa; Ghrelin; Humans; Male; Middle Aged; Retrospective Studies; Thiazoles | 2017 |
Adherence to an acotiamide therapeutic regimen improves long-term outcomes in patients with functional dyspepsia.
Topics: Adult; Aged; Benzamides; Cholinesterase Inhibitors; Dyspepsia; Female; Follow-Up Studies; Gastrointestinal Agents; Humans; Kaplan-Meier Estimate; Male; Medication Adherence; Middle Aged; Recurrence; Retrospective Studies; Risk Factors; Severity of Illness Index; Thiazoles; Treatment Outcome | 2017 |
Spectrofluorimetric determination of acotiamide hydrochloride trihydrate in the presence of its oxidative degradation product.
Topics: Benzamides; Chromatography, High Pressure Liquid; Gastrointestinal Agents; Hydrogen-Ion Concentration; Molecular Structure; Oxidation-Reduction; Spectrometry, Fluorescence; Surface-Active Agents; Thiazoles | 2018 |
Verification of a false positive in a two-year rat carcinogenicity study using dual control groups.
Topics: Adenocarcinoma; Administration, Oral; Animals; Benzamides; Carcinogenicity Tests; Control Groups; Endometrial Neoplasms; False Positive Reactions; Female; Rats, Inbred F344; Thiazoles; Time Factors | 2018 |
Real-World, Non-Interventional, Observational Study to Evaluate Effectiveness and Tolerability of Acotiamide Hydrochloride Hydrate in Treatment of Functional Dyspepsia.
Topics: Adult; Benzamides; Dyspepsia; Female; Gastrointestinal Agents; Gastrointestinal Diseases; Humans; India; Male; Middle Aged; Prospective Studies; Quality of Life; Thiazoles; Treatment Outcome | 2018 |
Camostat Mesilate, Pancrelipase, and Rabeprazole Combination Therapy Improves Epigastric Pain in Early Chronic Pancreatitis and Functional Dyspepsia with Pancreatic Enzyme Abnormalities.
Topics: Abdominal Pain; Aged; Benzamides; Drug Therapy, Combination; Dyspepsia; Esters; Female; Gabexate; Gastrointestinal Agents; Guanidines; Humans; Male; Middle Aged; Pancreatitis, Chronic; Pancrelipase; Rabeprazole; Thiazoles; Treatment Outcome | 2019 |
[A Case in Which Acotiamide Hydrochloride Was Effective for Reflux Esophagitis after Distal Gastrectomy with Billroth Ⅰ Reconstruction for Gastric Cancer].
Topics: Aged; Benzamides; Esophagitis, Peptic; Female; Gastrectomy; Gastroenterostomy; Humans; Neoplasm Recurrence, Local; Stomach Neoplasms; Thiazoles | 2019 |
Timing and Predictors of Recurrence of Dyspepsia Symptoms after Cessation of Acotiamide Therapy for Functional Dyspepsia: A Long-Term Observational Study.
Topics: Adult; Aged; Benzamides; Dyspepsia; Female; Gastrointestinal Agents; Humans; Kaplan-Meier Estimate; Longitudinal Studies; Male; Middle Aged; Patient Outcome Assessment; Proportional Hazards Models; Recurrence; Symptom Assessment; Thiazoles; Time Factors; Withholding Treatment | 2020 |
Efficacy of acotiamide hydrochloride hydrate added to α-blocker plus cholinergic drug combination therapy.
Topics: Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Benzamides; Cholinesterase Inhibitors; Drug Therapy, Combination; Female; Humans; Male; Thiazoles; Treatment Outcome; Urinary Bladder; Urinary Bladder, Underactive; Urination | 2019 |
Acotiamide attenuates central urocortin 2-induced intestinal inflammatory responses, and urocortin 2 treatment reduces TNF-α productions in LPS-stimulated macrophage cell lines.
Topics: Animals; Benzamides; Cell Line; Gastrointestinal Agents; Inflammation; Interleukin-6; Intestines; Lipopolysaccharides; Macrophages; Male; Phosphorylation; Rats; Rats, Sprague-Dawley; Signal Transduction; Thiazoles; Tumor Necrosis Factor-alpha; Urocortins | 2020 |
Identification of the Uptake Transporter Responsible for Distribution of Acotiamide into Stomach Tissue.
Topics: Acetylcholinesterase; Benzamides; Biological Transport; Cell Line; Cholinesterase Inhibitors; Dyspepsia; Endothelial Cells; Equilibrative Nucleoside Transport Proteins; Gastric Mucosa; HEK293 Cells; Humans; Muscle, Smooth; Selective Serotonin Reuptake Inhibitors; Stomach; Thiazoles | 2020 |
Excitatory effect of acotiamide on rat and human bladder: Implications for underactive bladder treatment.
Topics: Animals; Benzamides; Carbachol; Electric Stimulation; Humans; Male; Muscle Contraction; Rats, Sprague-Dawley; Thiazoles; Urinary Bladder; Urinary Bladder, Underactive | 2020 |
The rodent model of impaired gastric motility induced by allyl isothiocyanate, a pungent ingredient of wasabi, to evaluate therapeutic agents for functional dyspepsia.
Topics: Animals; Benzamides; Benzyl Compounds; Disease Models, Animal; Dyspepsia; Gastrointestinal Motility; Isothiocyanates; Male; Mice, Inbred Strains; Morpholines; Neostigmine; Panax; Phytotherapy; Plant Extracts; Thiazoles; Wasabia; Zanthoxylum; Zingiberaceae | 2021 |
The treatment effects of acotiamide in esophagogastric outflow obstruction: a prospective longitudinal observational study.
Topics: Benzamides; Esophagogastric Junction; Humans; Longitudinal Studies; Prospective Studies; Thiazoles | 2022 |
Application of Different UV Spectrophotometric Methods for Quantitative Analysis of Acotiamide and Esomeprazole.
Topics: Benzamides; Esomeprazole; Spectrophotometry; Tablets; Thiazoles | 2022 |