thiazoles and xct790

Topics: Animals; Base Sequence; Cell Line; Cell Line, Tumor; Chlorocebus aethiops; ERRalpha Estrogen-Related Receptor; Fluorescence Polarization; Gene Expression; Heat-Shock Proteins; HeLa Cells; Humans; Ligands; Mice; Molecular Sequence Data; Monoamine Oxidase; Mutation; Nitriles; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Receptors, Estrogen; Recombinant Proteins; Signal Transduction; Thiazoles; Transcription Factors; Transfection

Topics: Acrylamides; Animals; Benzaldehydes; Cells, Cultured; Combinatorial Chemistry Techniques; ERRalpha Estrogen-Related Receptor; Nitriles; Receptors, Cytoplasmic and Nuclear; Receptors, Estrogen; Signal Transduction; Stereoisomerism; Structure-Activity Relationship; Thiadiazoles; Thiazoles

Topics: Cells, Cultured; Cyclic AMP; ERRalpha Estrogen-Related Receptor; Fetus; Gene Expression Regulation; Humans; Lung; Nitriles; Promoter Regions, Genetic; Pulmonary Surfactant-Associated Protein A; Receptors, Cytoplasmic and Nuclear; Receptors, Estrogen; Thiazoles

Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Line, Tumor; Drug Synergism; ERRalpha Estrogen-Related Receptor; Estradiol; Estrogen Receptor alpha; Female; Fulvestrant; Gene Expression Regulation, Neoplastic; Humans; Nitriles; Prognosis; Proteasome Endopeptidase Complex; Receptors, Estrogen; Thiazoles

Topics: Anastrozole; Aromatase Inhibitors; Biological Assay; Cell Line, Tumor; Coumarins; ERRalpha Estrogen-Related Receptor; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Estrogens; Fulvestrant; Genes, Reporter; Genistein; Humans; Letrozole; Ligands; Luciferases; Nitriles; Receptors, Estrogen; Response Elements; Tamoxifen; Thiazoles; Transfection; Triazoles

Topics: Androgens; Cell Line, Tumor; Drug Inverse Agonism; ERRalpha Estrogen-Related Receptor; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Male; Nitriles; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Receptors, Estrogen; Response Elements; Signal Transduction; Thiazoles; Transcriptional Activation

Topics: Apoptosis; Blotting, Western; Caspases; Cell Line, Tumor; DNA, Mitochondrial; Drug Resistance, Neoplasm; ERRalpha Estrogen-Related Receptor; Humans; Mitochondria; Nitriles; Polymerase Chain Reaction; Reactive Oxygen Species; Receptors, Estrogen; Thiazoles

Topics: Animals; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Down-Regulation; ERRalpha Estrogen-Related Receptor; Gene Expression Regulation, Neoplastic; Humans; Mice; Neoplasms; Nitriles; Receptors, Estrogen; Thiazoles

Topics: Animals; Cell Line; Deoxyglucose; ERRalpha Estrogen-Related Receptor; Glucose; Glucose Transport Proteins, Facilitative; Ion Channels; Membrane Potential, Mitochondrial; Mitochondria, Muscle; Mitochondrial Proteins; Muscle Fibers, Skeletal; Nitriles; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Rats; Reactive Oxygen Species; Receptors, Estrogen; RNA-Binding Proteins; Thiazoles; Transcription Factors; Uncoupling Protein 3

Topics: Adipocytes; Animals; Animals, Newborn; Cloning, Molecular; Energy Metabolism; ERRalpha Estrogen-Related Receptor; Gene Expression Regulation; Lipid Metabolism; Molecular Sequence Data; Nitriles; Open Reading Frames; Polymerase Chain Reaction; Receptors, Estrogen; Swine; Thiazoles

Topics: Benzimidazoles; Carbocyanines; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Line, Tumor; Dose-Response Relationship, Drug; ERRalpha Estrogen-Related Receptor; Fluorescent Dyes; Humans; Lung; Lung Neoplasms; Membrane Potential, Mitochondrial; Membrane Potentials; Mitochondria; Nitriles; Reactive Oxygen Species; Receptors, Estrogen; Signal Transduction; Superoxide Dismutase; Thiazoles; Time Factors; Tumor Suppressor Protein p53

Topics: Adult; Cell Culture Techniques; Cells, Cultured; Decidua; Embryo Implantation; Endometrium; Energy Metabolism; ERRalpha Estrogen-Related Receptor; Female; Gene Expression Regulation; Hormone Antagonists; Humans; Nitriles; Pregnancy; Receptors, Estrogen; Stromal Cells; Thiazoles

Topics: Autocrine Communication; beta Catenin; Blotting, Western; Cadherins; Cell Line, Tumor; Cell Movement; Cell Survival; ERRalpha Estrogen-Related Receptor; Gene Expression Regulation, Neoplastic; HCT116 Cells; Heat-Shock Proteins; Humans; MSX1 Transcription Factor; Neoplasms; Nitriles; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Receptors, Estrogen; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; Thiazoles; Transcription Factors; Transcriptional Activation; Wnt Proteins

Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cells, Cultured; ERRalpha Estrogen-Related Receptor; Exercise; Gene Expression Regulation; Humans; Mice; Mice, Knockout; Muscle Fibers, Skeletal; Nitriles; Receptors, Estrogen; Sirtuin 1; Thiazoles; Transcription Factors; Transcription, Genetic

Topics: Cell Line, Tumor; Epidermal Growth Factor; ErbB Receptors; ERRalpha Estrogen-Related Receptor; Genistein; HCT116 Cells; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Ligands; Nitriles; Orphan Nuclear Receptors; Piperidines; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Estrogen; RNA, Messenger; Thiazoles; Up-Regulation

Topics: Animals; Cells, Cultured; ERRalpha Estrogen-Related Receptor; Fibroblasts; Gene Expression Regulation; Genes, ras; Humans; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Protein Kinases; Protein Serine-Threonine Kinases; ras Proteins; Receptors, Estrogen; Thiazoles; Trans-Activators; Transcription Factors

Topics: Animals; Butadienes; Cell Differentiation; Creatine Kinase, Mitochondrial Form; Dual Specificity Phosphatase 1; ERRalpha Estrogen-Related Receptor; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression; Kinetics; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Mitogen-Activated Protein Kinase Kinases; Muscle Development; Muscle Fibers, Skeletal; Muscle Proteins; Myoblasts, Skeletal; Myogenin; Myosin Heavy Chains; Nitriles; p38 Mitogen-Activated Protein Kinases; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Receptors, Estrogen; Ribosomal Protein S6 Kinases, 90-kDa; Sarcomeres; Thiazoles; Trans-Activators; Transcription Factors; Transduction, Genetic; Troponin I; Up-Regulation

Topics: Acyl-CoA Dehydrogenase; Analysis of Variance; Apoptosis; Carbazoles; Caspases; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cloning, Molecular; ERRalpha Estrogen-Related Receptor; Homeostasis; Humans; Indoles; Maleimides; Membrane Potential, Mitochondrial; Mitochondria; Nitriles; PPAR alpha; Protein Kinase C-epsilon; Reactive Oxygen Species; Receptors, Estrogen; Signal Transduction; Succinate Dehydrogenase; Thiazoles; Transfection

Topics: Breast Neoplasms; Carrier Proteins; Cell Proliferation; ERRalpha Estrogen-Related Receptor; Female; Humans; Nitriles; Receptor, ErbB-2; Receptor, IGF Type 1; Receptors, Estrogen; RNA-Binding Proteins; Signal Transduction; Thiazoles

Topics: 5' Flanking Region; Animals; Binding Sites; Carnitine Acyltransferases; ERRalpha Estrogen-Related Receptor; Fasting; Gene Expression; Gene Expression Regulation, Enzymologic; HEK293 Cells; Humans; Mice; Muscle, Skeletal; Nitriles; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Receptors, Estrogen; Thiazoles; Trans-Activators; Transcription Factors; Transcription, Genetic; Transcriptional Activation

Topics: Base Pairing; Cell Line; ERRalpha Estrogen-Related Receptor; Gene Expression Regulation; Humans; Nitriles; Osteoblasts; Osteocalcin; Promoter Regions, Genetic; Protein Binding; Receptors, Estrogen; RNA, Messenger; Thiazoles; Transcription Factors

Topics: Air Pollutants, Occupational; Benzhydryl Compounds; Biological Assay; Blotting, Western; ERRalpha Estrogen-Related Receptor; Genistein; HEK293 Cells; Humans; Luciferases; Nitriles; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phenols; Phytoestrogens; Receptors, Estrogen; Recombinant Fusion Proteins; Signal Transduction; Thiazoles; Transcription Factors; Transfection; Xenobiotics

Topics: Animals; Cadherins; Cell Proliferation; Cells, Cultured; Cytoskeletal Proteins; Dose-Response Relationship, Drug; ERRalpha Estrogen-Related Receptor; GTPase-Activating Proteins; Male; MAP Kinase Signaling System; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitriles; Nuclear Proteins; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; RNA, Messenger; Thiazoles; Transcription Factors; Vascular Endothelial Growth Factor A

Topics: Animals; Cell Proliferation; Cells, Cultured; Chondrocytes; Down-Regulation; ERRalpha Estrogen-Related Receptor; Estradiol; Female; Growth Differentiation Factor 5; Mandibular Condyle; Nitriles; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; RNA, Messenger; SOX9 Transcription Factor; Thiazoles; Up-Regulation

Topics: Cell Line; Cell Survival; Drug Inverse Agonism; ERRalpha Estrogen-Related Receptor; Humans; Membrane Potential, Mitochondrial; Mitochondria; Nitriles; Oxidation-Reduction; Oxygen Consumption; Phosphorylation; Proton Ionophores; Receptors, Estrogen; Thiazoles

Topics: Angiogenesis Inhibitors; Angiopoietin-2; Animals; Cell Proliferation; Disease Models, Animal; Endothelial Cells; ERRalpha Estrogen-Related Receptor; Male; Neovascularization, Pathologic; Nitriles; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Random Allocation; Rats, Sprague-Dawley; Receptors, Estrogen; Spinal Cord Injuries; Thiazoles; Transcription Factors; Vascular Endothelial Growth Factor A

Topics: Animals; Basigin; Breast Neoplasms; Cell Line, Tumor; ERRalpha Estrogen-Related Receptor; Female; Humans; Isoenzymes; L-Lactate Dehydrogenase; Lactate Dehydrogenase 5; Lactic Acid; Mice, Inbred BALB C; Monocarboxylic Acid Transporters; Muscle Proteins; Nitriles; Physical Conditioning, Animal; Receptors, Estrogen; Symporters; Thiazoles; Tumor Burden

Topics: Acetylcarnitine; Breast Neoplasms; Cell Adhesion; Cell Proliferation; Cell Survival; Chromatography, Liquid; Doxycycline; ERRalpha Estrogen-Related Receptor; Forkhead Box Protein M1; Forkhead Transcription Factors; Glycolysis; Humans; MCF-7 Cells; Mitochondria; Neoplastic Stem Cells; Nitriles; Oligomycins; Organelle Biogenesis; Oxidative Phosphorylation; Proteomics; Receptors, Estrogen; Signal Transduction; Spheroids, Cellular; Tandem Mass Spectrometry; Thiazoles; Wnt Signaling Pathway

Topics: Animals; Antineoplastic Agents; Binding Sites; Cell Movement; Dose-Response Relationship, Drug; Drug Inverse Agonism; Epithelial-Mesenchymal Transition; ERRalpha Estrogen-Related Receptor; Female; Fibronectins; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Lung Neoplasms; MCF-7 Cells; Mice, Nude; Middle Aged; Nitriles; Promoter Regions, Genetic; Protein Binding; Receptors, Estrogen; Retrospective Studies; RNA Interference; Signal Transduction; Thiazoles; Time Factors; Transfection; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays

Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Animals; Antineoplastic Agents, Hormonal; Autophagy; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Partial Agonism; Energy Metabolism; ERRalpha Estrogen-Related Receptor; G1 Phase Cell Cycle Checkpoints; Humans; Mice, Nude; Mitochondria; Molecular Targeted Therapy; Necrosis; Nitriles; Receptors, Estrogen; Signal Transduction; Thiazoles; Time Factors; Xenograft Model Antitumor Assays

Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; ERRalpha Estrogen-Related Receptor; Female; Humans; Mice; Nitriles; Reactive Oxygen Species; Receptors, Estrogen; Signal Transduction; Thiazoles; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays

Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; ERRalpha Estrogen-Related Receptor; Female; Humans; Molecular Structure; Nitriles; Receptors, Estrogen; Structure-Activity Relationship; Thiazoles; Triple Negative Breast Neoplasms

Topics: Catalytic Domain; Chromatin; Dioxygenases; Gene Expression Regulation; HEK293 Cells; Humans; Immunoprecipitation; Mutation; Nitriles; Protein Interaction Domains and Motifs; Receptors, Androgen; Thiazoles; Thyroid Hormone Receptors alpha; Thyroid Hormone Receptors beta; Transcription, Genetic; Ubiquitination

Topics: Animals; Arvicolinae; Hydrazines; Leydig Cells; Male; Microscopy, Electron, Transmission; Nitriles; Receptors, Estrogen; Signal Transduction; Thiazoles

Topics: Carcinoma; Cell Movement; Cell Proliferation; Colorectal Neoplasms; ERRalpha Estrogen-Related Receptor; HCT116 Cells; HT29 Cells; Humans; Interleukin-8; MAP Kinase Signaling System; Nitriles; Receptors, Estrogen; STAT3 Transcription Factor; Thiazoles

Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Down-Regulation; Epithelial-Mesenchymal Transition; ERRalpha Estrogen-Related Receptor; Fibronectins; Gene Expression Regulation, Neoplastic; Humans; Nitriles; Receptors, Estrogen; Signal Transduction; Skin Neoplasms; STAT3 Transcription Factor; Thiazoles

Topics: Adenine; Animals; Apoptosis; Autophagy; Cell Line; Endothelial Cells; ERRalpha Estrogen-Related Receptor; Macrolides; Membrane Potential, Mitochondrial; Mice; Microtubule-Associated Proteins; Mitochondria; Nitric Oxide Synthase Type III; Nitriles; Reactive Oxygen Species; Receptors, Estrogen; RNA Interference; RNA, Small Interfering; Signal Transduction; Thiazoles; Ubiquitin-Protein Ligases; Ubiquitination

Topics: Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Cisplatin; Doxorubicin; Drug Resistance, Neoplasm; ERRalpha Estrogen-Related Receptor; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; Nitriles; Osteosarcoma; Protein Binding; Receptors, Estrogen; RNA Interference; Sp3 Transcription Factor; Thiazoles

Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Endometrial Neoplasms; ERRalpha Estrogen-Related Receptor; Estrogen Receptor alpha; Female; Humans; Mice; Mice, Inbred BALB C; Nitriles; Paclitaxel; Proto-Oncogene Proteins c-akt; Receptors, Estrogen; Signal Transduction; Thiazoles; TOR Serine-Threonine Kinases; Transcription, Genetic; Tubulin; Xenograft Model Antitumor Assays

Topics: Animals; ERRalpha Estrogen-Related Receptor; Fatty Acids; Glycine max; HEK293 Cells; Humans; Isoflavones; Lipid Metabolism; Mice; Muscle Fibers, Skeletal; Muscle, Skeletal; Nitriles; Oxidation-Reduction; Oxidative Phosphorylation; Receptors, Estrogen; Thiazoles

Topics: Animals; Benzodioxoles; ERRalpha Estrogen-Related Receptor; Gene Expression; High-Throughput Nucleotide Sequencing; Male; Mice; Mice, Inbred C57BL; Nitriles; Nucleophosmin; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Testis; Thiazoles; Transcriptome

Topics: Anilides; Apoptosis; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Endometrial Neoplasms; ERRalpha Estrogen-Related Receptor; Female; Gene Expression Regulation, Neoplastic; Humans; Middle Aged; Nitriles; PPAR gamma; Receptors, Estrogen; ROC Curve; Thiazoles

Topics: Algorithms; Animals; Aortic Valve; Aortic Valve Disease; Aortic Valve Stenosis; Calcinosis; Disease Models, Animal; Drug Discovery; Drug Evaluation, Preclinical; Gene Expression Regulation; Gene Regulatory Networks; Haploinsufficiency; Humans; Induced Pluripotent Stem Cells; Machine Learning; Mice, Inbred C57BL; Nitriles; Receptor, Notch1; RNA-Seq; Small Molecule Libraries; Thiazoles

Topics: alpha-Synuclein; Cytoprotection; Indoles; Macroautophagy; Models, Biological; Nitriles; Oximes; Protein Aggregates; Proteolysis; Saccharomyces cerevisiae; Thiazoles

Topics: Aortic Valve; Aortic Valve Stenosis; Calcinosis; Cardiovascular Agents; Endothelial Cells; ERRalpha Estrogen-Related Receptor; Gene Regulatory Networks; Humans; Induced Pluripotent Stem Cells; Machine Learning; Nitriles; Receptor, Notch1; Receptors, Estrogen; Thiazoles

Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle; Deoxycytidine; Drug Synergism; Epithelial-Mesenchymal Transition; ERRalpha Estrogen-Related Receptor; Gemcitabine; Humans; MAP Kinase Signaling System; Nitriles; Pancreatic Neoplasms; Receptors, Estrogen; Thiazoles; Xenograft Model Antitumor Assays