Compounds > thiazoles
Page last updated: 2024-08-21

thiazoles and vu0409106

thiazoles has been researched along with vu0409106 in 4 studies

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bates, BS; Blobaum, AL; Brewer, KA; Bridges, TM; Byers, FW; Conn, PJ; Corlew, MM; Daniels, JS; Emmitte, KA; Felts, AS; Jones, CK; Lindsley, CW; Manka, J; Morrison, RD; Niswender, CM; Rodriguez, AL; Rush, R; Sanchez-Ponce, R; Santomango, TS; Stec, D; Venable, DF1
Bates, BS; Blobaum, AL; Byers, FW; Conn, PJ; Daniels, JS; Emmitte, KA; Felts, AS; Jones, CK; Lindsley, CW; Manka, JT; Morrison, RD; Niswender, CM; Rodriguez, AL; Venable, DF1
Ansari, MS; Conn, PJ; Daniels, JS; Emmitte, KA; Felts, AS; Jones, CK; Kessler, RM; Lindsley, CW; Niswender, CM; Rook, JM; Stauffer, SR; Tantawy, MN1
Byers, FW; Crouch, RD; Daniels, JS; Emmitte, KA; Lindsley, CW; Morrison, RD1

Other Studies

4 other study(ies) available for thiazoles and vu0409106

ArticleYear
The role of aldehyde oxidase and xanthine oxidase in the biotransformation of a novel negative allosteric modulator of metabotropic glutamate receptor subtype 5.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:9

    Topics: Aldehyde Oxidase; Allopurinol; Animals; Benzamides; Biotransformation; Chromatography, Liquid; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Hepatocytes; Humans; Hydroxylation; Injections, Intravenous; Liver; Macaca fascicularis; Magnetic Resonance Spectroscopy; Male; Metabolic Clearance Rate; Microsomes, Liver; Models, Biological; Molecular Structure; Oxygen Isotopes; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Species Specificity; Tandem Mass Spectrometry; Thiazoles; Xanthine Oxidase

2012
Discovery of VU0409106: A negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety.
    Bioorganic & medicinal chemistry letters, 2013, Nov-01, Volume: 23, Issue:21

    Topics: Allosteric Regulation; Allosteric Site; Animals; Anxiety; Benzamides; Mice; Receptor, Metabotropic Glutamate 5; Structure-Activity Relationship; Thiazoles

2013
Relationship between in vivo receptor occupancy and efficacy of metabotropic glutamate receptor subtype 5 allosteric modulators with different in vitro binding profiles.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015, Volume: 40, Issue:3

    Topics: Allosteric Regulation; Amphetamine; Animals; Benzamides; Calcium; Cerebellum; Corpus Striatum; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Locomotion; Male; Maze Learning; Niacinamide; Piperidines; Positron-Emission Tomography; Radioligand Assay; Rats; Receptor, Metabotropic Glutamate 5; Structure-Activity Relationship; Thiazoles

2015
Evaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 Activity.
    Drug metabolism and disposition: the biological fate of chemicals, 2016, Volume: 44, Issue:8

    Topics: Administration, Oral; Aldehyde Oxidase; Animals; Area Under Curve; Benzamides; Biotransformation; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Male; Metabolic Clearance Rate; Microsomes, Liver; Rats, Sprague-Dawley; Risk Assessment; Substrate Specificity; Thiazoles; Triazoles

2016