thiazoles has been researched along with u 0126 in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 11 (47.83) | 29.6817 |
| 2010's | 11 (47.83) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| de Caestecker, MP; Watanabe, H; Yamada, Y | 1 |
| Iwata, A; Kanazawa, I; Maruyama, M; Nukina, N | 1 |
| Baluska, F; Bögre, L; Hirt, H; Hlavacka, A; Lecourieux, F; Lenart, P; Lichtscheidl, I; Meskiene, I; Ovecka, M; Salaj, J; Samaj, J; Volkmann, D | 1 |
| Davis, KE; Farmer, SR; Park, BH; Prusty, D | 1 |
| Dmitrieva, RI; Doris, PA | 1 |
| Behl, C; Conrad, S; Goodenough, S; Skutella, T | 1 |
| Liot, G; Lobner, D | 1 |
| Adachi, N; Hatanaka, H; Ikeuchi, T; Matsumoto, T; Numakawa, T; Shimoke, K; Yamada, M; Yamagishi, S; Yokomaku, D | 1 |
| Cameron, RE; Dragunow, M; Gray, CW; Lim, J; Lind, CR; Narayan, PJ; O'Carroll, SJ; Pearson, AG | 1 |
| Dent, P; Grant, S; Harada, H; Nguyen, TK; Rahmani, M | 1 |
| Daub, H; Mann, M; Olsen, JV; Pan, C | 1 |
| Huss, JM; Murray, J | 1 |
| Kay, EP; Lee, JG; Smith, RE; Song, JS | 1 |
| Corey, SJ; Park, BJ; Whichard, ZL | 1 |
| Calandra, RS; Cigorraga, SB; Frungieri, MB; Matzkin, ME; Pellizzari, EH; Rossi, SP | 1 |
| Chen, Y; Kuang, F; Liu, L; Peng, Z; Tan, Q; Wang, H; Wang, L; Xue, F; Yang, F; Zhang, R | 1 |
| Ashraf, MI; Cutress, RI; Deutsch, M; Enthammer, M; Khalid, S; Koziel, K; Packham, G; Papadakis, ES; Salomé Gachet, M; Schwaiger, S; Stuppner, H; Troppmair, J; Wolber, G | 1 |
| Bussink, J; Grénman, R; Iida, M; Kaanders, JH; Peeters, WJ; Span, PN; Stegeman, H; van der Kogel, AJ; Verheijen, MM; Wheeler, DL | 1 |
| Gong, YP; Guo, Y; Lin, J; Shi, R | 1 |
| Boitano, S; Burgos-Vega, CC; Dussor, G; Hassler, SN; Price, TJ; Quinn, TL; Sorge, RE; Tillu, DV; Vagner, J | 1 |
| Liu, Y; Zhang, M; Zhang, P; Zhou, Y | 1 |
| Chiba, K; Fujisawa, M; Okada, K; Tanaka, M | 1 |
| Cao, N; Chen, Q; Deng, S; Gao, R; Kong, L; Li, L; Ma, K; Si, J; Tan, C; Tang, X; Wang, Y; Xu, Z; Zhang, J; Zhang, L; Zhang, M | 1 |
1 trial(s) available for thiazoles and u 0126
| Article | Year |
|---|---|
MEK1/2 inhibitors sensitize Bcr/Abl+ human leukemia cells to the dual Abl/Src inhibitor BMS-354/825.
Topics: Benzamides; Butadienes; Dasatinib; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Fusion Proteins, bcr-abl; Gene Expression Regulation, Leukemic; Humans; Imatinib Mesylate; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Nitriles; Piperazines; Protein Kinase Inhibitors; Pyrimidines; src-Family Kinases; Thiazoles | 2007 |
22 other study(ies) available for thiazoles and u 0126
| Article | Year |
|---|---|
Transcriptional cross-talk between Smad, ERK1/2, and p38 mitogen-activated protein kinase pathways regulates transforming growth factor-beta-induced aggrecan gene expression in chondrogenic ATDC5 cells.
Topics: Aggrecans; Animals; Butadienes; Cell Differentiation; Cell Line; Cell Nucleus; Chondrocytes; Cycloheximide; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Activation; Extracellular Matrix Proteins; Gene Expression Regulation, Enzymologic; Genes, Dominant; Imidazoles; Immunoblotting; Lectins, C-Type; Luciferases; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Synthesis Inhibitors; Proteoglycans; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Smad Proteins; Thiazoles; Time Factors; Trans-Activators; Transcription, Genetic; Transfection; Transforming Growth Factor beta | 2001 |
alpha-Synuclein affects the MAPK pathway and accelerates cell death.
Topics: 14-3-3 Proteins; alpha-Synuclein; Amino Acid Sequence; Apoptosis; Blotting, Northern; Butadienes; Cell Death; Cell Line; Cell Survival; Coloring Agents; DNA, Complementary; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Library; Glutathione Transferase; Humans; Immunoblotting; Immunohistochemistry; In Situ Nick-End Labeling; MAP Kinase Signaling System; Molecular Sequence Data; Mutation; Nerve Tissue Proteins; Nitriles; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Signal Transduction; Synucleins; Tetrazolium Salts; Thiazoles; Time Factors; Transfection; Tyrosine 3-Monooxygenase | 2001 |
Involvement of the mitogen-activated protein kinase SIMK in regulation of root hair tip growth.
Topics: Actin Cytoskeleton; Actins; Active Transport, Cell Nucleus; Bridged Bicyclo Compounds, Heterocyclic; Butadienes; Cell Nucleus; Cell Polarity; Cell Surface Extensions; Cytoplasm; Depsipeptides; Enzyme Activation; MAP Kinase Signaling System; Medicago sativa; Microscopy, Video; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nicotiana; Nitriles; Peptides, Cyclic; Plant Proteins; Plant Roots; Recombinant Fusion Proteins; Thiazoles; Thiazolidines | 2002 |
Activation of MEK/ERK signaling promotes adipogenesis by enhancing peroxisome proliferator-activated receptor gamma (PPARgamma ) and C/EBPalpha gene expression during the differentiation of 3T3-L1 preadipocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Adipocytes; Animals; Butadienes; CCAAT-Enhancer-Binding Protein-alpha; Cell Differentiation; Chromans; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Activation; Gene Expression Regulation; Insulin; MAP Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitriles; Phosphorylation; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
Ouabain is a potent promoter of growth and activator of ERK1/2 in ouabain-resistant rat renal epithelial cells.
Topics: Animals; Biological Transport; Blotting, Western; Bromodeoxyuridine; Butadienes; Cell Division; Cells, Cultured; Coloring Agents; DNA; Dose-Response Relationship, Drug; Drug Resistance; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Histones; Inhibitory Concentration 50; Ions; Kidney; Male; Mitochondria; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitriles; Ouabain; Phosphorylation; Protein Isoforms; Rats; Regression Analysis; Signal Transduction; Sodium; Sodium-Potassium-Exchanging ATPase; Tetrazolium Salts; Thiazoles; Time Factors | 2003 |
Inactivation of glycogen synthase kinase-3beta protects against kainic acid-induced neurotoxicity in vivo.
Topics: Animals; Behavior, Animal; Blotting, Western; Butadienes; Cell Death; Cell Survival; Cerebellum; Enzyme Activation; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; Immunohistochemistry; Kainic Acid; Lithium Chloride; Male; Mice; Mitogen-Activated Protein Kinase 1; Neurotoxicity Syndromes; Nitriles; Organ Culture Techniques; Phosphorylation; Serine; Tetrazolium Salts; Thiazoles; Time Factors; Tyrosine | 2004 |
Role of MAPK/ERK in neurotrophin-4 potentiation of necrotic neuronal death.
Topics: Animals; Butadienes; Cell Death; Cells, Cultured; Cyclosporine; Enzyme Activation; Flavonoids; Immunosuppressive Agents; L-Lactate Dehydrogenase; Mice; Mitogen-Activated Protein Kinases; Necrosis; Nerve Growth Factors; Neurons; Nitriles; Phosphorylation; Tetrazolium Salts; Thiazoles | 2004 |
ERK1/2 are involved in low potassium-induced apoptotic signaling downstream of ASK1-p38 MAPK pathway in cultured cerebellar granule neurons.
Topics: Adenoviridae; Animals; Apoptosis; Blotting, Western; Butadienes; Cells, Cultured; Cerebellum; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Immunohistochemistry; Male; MAP Kinase Kinase Kinase 5; Mitogen-Activated Protein Kinase 7; Neurons; Nitriles; p38 Mitogen-Activated Protein Kinases; Potassium Deficiency; Rats; Rats, Wistar; Signal Transduction; Tetrazolium Salts; Thiazoles | 2005 |
The mitogen-activated/extracellular signal-regulated kinase kinase 1/2 inhibitor U0126 induces glial fibrillary acidic protein expression and reduces the proliferation and migration of C6 glioma cells.
Topics: Analysis of Variance; Animals; Blotting, Western; Bromodeoxyuridine; Butadienes; Caspase 3; Cell Count; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression; Glial Fibrillary Acidic Protein; Glioma; Immunohistochemistry; Mice; Nitriles; Tetrazolium Salts; Thiazoles | 2006 |
Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics.
Topics: Butadienes; Dasatinib; Databases, Protein; Epidermal Growth Factor; Fusion Proteins, bcr-abl; HeLa Cells; Humans; Imidazoles; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mitogen-Activated Protein Kinase Kinases; Models, Biological; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphoproteins; Phosphorylation; Protein Kinase Inhibitors; Proteome; Proteomics; Pyridines; Pyrimidines; Signal Transduction; Thiazoles; Up-Regulation | 2009 |
Estrogen-related receptor α regulates skeletal myocyte differentiation via modulation of the ERK MAP kinase pathway.
Topics: Animals; Butadienes; Cell Differentiation; Creatine Kinase, Mitochondrial Form; Dual Specificity Phosphatase 1; ERRalpha Estrogen-Related Receptor; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression; Kinetics; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Mitogen-Activated Protein Kinase Kinases; Muscle Development; Muscle Fibers, Skeletal; Muscle Proteins; Myoblasts, Skeletal; Myogenin; Myosin Heavy Chains; Nitriles; p38 Mitogen-Activated Protein Kinases; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Receptors, Estrogen; Ribosomal Protein S6 Kinases, 90-kDa; Sarcomeres; Thiazoles; Trans-Activators; Transcription Factors; Transduction, Genetic; Troponin I; Up-Regulation | 2011 |
Human corneal endothelial cells employ phosphorylation of p27(Kip1) at both Ser10 and Thr187 sites for FGF-2-mediated cell proliferation via PI 3-kinase.
Topics: Adolescent; Adult; Aged; Butadienes; Cell Proliferation; Chromones; Cyclin-Dependent Kinase Inhibitor p27; Endothelium, Corneal; Enzyme Inhibitors; Fibroblast Growth Factor 2; Humans; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Microscopy, Confocal; Middle Aged; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; RNA, Small Interfering; Serine; Tetrazolium Salts; Thiazoles; Threonine; Tissue Donors; Transfection; Young Adult | 2011 |
Dasatinib synergizes with both cytotoxic and signal transduction inhibitors in heterogeneous breast cancer cell lines--lessons for design of combination targeted therapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Benzenesulfonates; Breast Neoplasms; Butadienes; Cell Line, Tumor; Chromones; Dasatinib; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Epothilones; Female; Humans; Morpholines; Niacinamide; Nitriles; Paclitaxel; Phenylurea Compounds; Pyridines; Pyrimidines; Signal Transduction; Sirolimus; Sorafenib; Tamoxifen; Thiazoles | 2012 |
Exploring the cyclooxygenase 2 (COX2)/15d-Δ(12,14)PGJ(2) system in hamster Sertoli cells: regulation by FSH/testosterone and relevance to glucose uptake.
Topics: Androgen Antagonists; Anilides; Animals; Butadienes; Cricetinae; Cyclooxygenase 2; Deoxyglucose; Follicle Stimulating Hormone; Glucose; Male; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Meloxicam; Mesocricetus; Nitriles; Phosphorylation; Prostaglandin D2; Sertoli Cells; Testosterone; Thiazines; Thiazoles; Tosyl Compounds | 2012 |
Ziprasidone ameliorates anxiety-like behaviors in a rat model of PTSD and up-regulates neurogenesis in the hippocampus and hippocampus-derived neural stem cells.
Topics: Animals; Anti-Anxiety Agents; Butadienes; Cell Proliferation; Cell Survival; Cells, Cultured; Hippocampus; Male; MAP Kinase Signaling System; Neural Stem Cells; Neurogenesis; Nitriles; Piperazines; Protein Kinase Inhibitors; Rats; Stress Disorders, Post-Traumatic; Thiazoles; Up-Regulation | 2013 |
Isolation of a novel thioflavin S-derived compound that inhibits BAG-1-mediated protein interactions and targets BRAF inhibitor-resistant cell lines.
Topics: Aniline Compounds; Animals; Antineoplastic Agents; Benzothiazoles; Binding Sites; Butadienes; Cell Line; Cell Proliferation; DNA-Binding Proteins; Fluorescent Dyes; HEK293 Cells; HSC70 Heat-Shock Proteins; Humans; Indoles; MCF-7 Cells; Mice; Molecular Docking Simulation; Neoplasms; NIH 3T3 Cells; Nitriles; Protein Binding; Proto-Oncogene Proteins B-raf; Sulfonamides; Thiazoles; Transcription Factors; Vemurafenib | 2013 |
Combining radiotherapy with MEK1/2, STAT5 or STAT6 inhibition reduces survival of head and neck cancer lines.
Topics: Antineoplastic Agents; Butadienes; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; Chemoradiotherapy; Dasatinib; Drug Screening Assays, Antitumor; Head and Neck Neoplasms; Humans; Imidazoles; Isoxazoles; Leflunomide; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Nitriles; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Radiation Tolerance; STAT5 Transcription Factor; STAT6 Transcription Factor; Thiazoles; Tumor Suppressor Proteins | 2013 |
The MEK1/2 inhibitor U0126 reverses imatinib resistance through down-regulating activation of Lyn/ERK signaling pathway in imatinib-resistant K562R leukemia cells.
Topics: Antineoplastic Agents; Benzamides; Blotting, Western; Butadienes; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Inhibitors; Flow Cytometry; Humans; Imatinib Mesylate; Indicators and Reagents; K562 Cells; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Nitriles; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; Pyrimidines; Real-Time Polymerase Chain Reaction; src-Family Kinases; STAT5 Transcription Factor; Tetrazolium Salts; Thiazoles; TOR Serine-Threonine Kinases | 2014 |
Protease-activated receptor 2 activation is sufficient to induce the transition to a chronic pain state.
Topics: Animals; Azepines; Behavior, Animal; Benzamides; Brain-Derived Neurotrophic Factor; Butadienes; Chronic Pain; Dinoprostone; Disease Models, Animal; Facial Expression; Hydrazones; Hyperalgesia; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Nitriles; Protein Kinase C; Receptor, PAR-2; Receptor, trkB; Signal Transduction; Thiazoles | 2015 |
GSK3 inhibitor AR-A014418 promotes osteogenic differentiation of human adipose-derived stem cells via ERK and mTORC2/Akt signaling pathway.
Topics: Adipose Tissue; Butadienes; Cell Differentiation; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Humans; Mechanistic Target of Rapamycin Complex 2; Multiprotein Complexes; Nitriles; Osteogenesis; Proto-Oncogene Proteins c-akt; Signal Transduction; Stem Cells; Structure-Activity Relationship; Thiazoles; TOR Serine-Threonine Kinases; Urea | 2017 |
Effect of mirabegron on tight junction molecules in primary cultured rat Sertoli cells.
Topics: Acetanilides; Adrenergic beta-3 Receptor Agonists; Animals; Blood-Testis Barrier; Butadienes; Cells, Cultured; Claudins; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Sertoli Cells; Signal Transduction; Spermatogenesis; Thiazoles; Tight Junctions | 2019 |
The Role of TMEM16A/ERK/NK-1 Signaling in Dorsal Root Ganglia Neurons in the Development of Neuropathic Pain Induced by Spared Nerve Injury (SNI).
Topics: Animals; Anoctamins; Butadienes; Chronic Pain; Extracellular Signal-Regulated MAP Kinases; Ganglia, Spinal; Hyperalgesia; Ligation; Male; Neuralgia; Nitriles; Nociception; Peroneal Nerve; Pyrimidines; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Sensory Receptor Cells; Signal Transduction; Thiazoles; Tibial Nerve | 2021 |