thiazoles has been researched along with thiophenes in 330 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (7.27) | 18.7374 |
| 1990's | 19 (5.76) | 18.2507 |
| 2000's | 51 (15.45) | 29.6817 |
| 2010's | 194 (58.79) | 24.3611 |
| 2020's | 42 (12.73) | 2.80 |
| Authors | Studies |
|---|---|
| Hayashi, M; Iguchi, Y; Iizuka, K; Kajiwara, I; Kawamura, M; Miyamoto, T; Nakazawa, M; Ohyama, I; Okada, T; Taniguchi, K; Tanouchi, T | 1 |
| Katz, N | 1 |
| Roffey, P; Verge, JP | 1 |
| Budĕsínský, Z; Capek, A; Sváb, A | 1 |
| Garbusov, V; Golovnja, RV; Rehfeld, G; Rothe, M; Wölm, G | 1 |
| Bryan, GT; Muraoka, K; Wang, CY | 1 |
| Günther, O; Hartke, K | 1 |
| Aboulwafa, OM; Ismail, KA; Koreish, EA | 1 |
| Aboul Wafa, OM; Berto, FA | 1 |
| Nare, B; Prichard, RK; Smith, JM | 1 |
| Caruso, A; Cutuli, V; Guerrera, F; Leone, MG; Oliveri, S; Sarvà, MC; Siracusa, MA | 1 |
| Kubo, K; Nomoto, Y; Ohno, T; Takai, H | 1 |
| Barney, CL; Burkhard, T; Ertel, MA; Kariya, T; Kastner, PR; Marshall, FN; Matthews, DP; McCarthy, JR; Shea, PJ; Whitten, JP | 1 |
| Clark, DP; Juhl, MJ | 1 |
| Morris, RL; Nielsen, ST; Santilli, AA; Schiehser, GA; Scotese, AC; Strike, DP; Teller, DM | 1 |
| Kass, MA | 1 |
| Hwang, SB; Lam, MH | 1 |
| Bousquet, E; Cammarata, E; Oliveri, S; Pappalardo, MS; Romeo, G; Ronsisvalle, G | 1 |
| Gautheron, P; Grove, J; Plazonnet, B; Sugrue, MF | 1 |
| Hatanaka, M; Ishimaru, T | 1 |
| Nagase, H | 1 |
| Colglazier, ML; Enzie, FD; Kates, KC; Lindahl, IL; Samuelson, G | 1 |
| Prichard, RK | 1 |
| Berk, S; Gisser, H | 1 |
| Czerlinski, GH; Galuszka, RA | 1 |
| Austin, WC; Cornwell, RL; Jones, RM; Robinson, M | 1 |
| Forbes, LS | 1 |
| Dunoff, RY; Graboyes, H; Jaffe, G; Karash, CB; Pachter, IJ; Snader, K; Weinstock, J | 1 |
| Balucani, D; Buu-Hoï, NP; Martani, A; Ricci, A; Saint-Ruf, G | 1 |
| Bergstrom, DA; Gonzalez, AM; Huang, KX; Kreiss, DS; Sibley, DR; Walters, JR | 1 |
| Bian, SS; Chen, YL; Lee, H | 1 |
| Brocco, M; Gobert, A; Millan, MJ; Schreiber, R; Veiga, S | 1 |
| Bajié, M; Boykin, DW; Fiser-Jakić, L; Karminski-Zamola, G; Tralić-Kulenović, V | 1 |
| Broom, NJ; Elder, JS; Hannan, PC; O'Hanlon, PJ; Pons, JE; Walker, G; Wilson, J; Woodall, P | 1 |
| Behroozi, SJ; Dannaldson, J; Gates, KS; Kim, W | 1 |
| Rainsford, KD; Smith, F; Ying, C | 1 |
| Cunningham, AM; Hipkiss, AR; Mayer, S; Michaelis, J; Müller, R; Münch, G; Neumann, A; Riederer, P; Schinzel, R | 1 |
| Beani, JC; Emonet, N; Favier, A; Leccia, MT; Richard, MJ | 1 |
| Algueró, M; Bartroli, J; Boncompte, E; Conte, L; Forn, J; García-Rafanell, J; Merlos, M; Ramis, J; Turmo, E; Vericat, ML | 1 |
| Inguaggiato, G; Jasamai, M; Simons, C; Slater, M; Smith, JE | 1 |
| Doss, SH; Elmegeed, GA; Louca, NA; Mohareb, RM | 1 |
| Bone, R; DesJarlais, RL; Grasberger, B; Green, D; Hoffman, JB; Illig, CR; Lewandowski, FA; Maguire, D; Molloy, CJ; Randall, T; Rudolph, MJ; Sharp, C; Soll, R; Spurlino, J; Subasinghe, N; Wilson, KJ; Zhang, M; Zhou, Z | 1 |
| Beach, TG; Fisher, A; Potter, PE; Sue, LI; Walker, DG | 1 |
| Doss, SH; Louca, NA; Wardakhan, WW | 1 |
| Inoue, Y; Ishikawa, H; Katsura, Y; Matsumoto, Y; Morinaga, C; Nishino, S; Sakane, K; Takasugi, H | 1 |
| Nelson, SD | 1 |
| Bone, R; Deckman, IC; DesJarlais, RL; Grasberger, BL; Green, D; Hoffman, JB; Illig, CR; Lewandowski, F; Maguire, D; Manthey, C; Molloy, CJ; Randle, T; Rudolph, MJ; Sharp, C; Soll, RM; Spurlino, JC; Subasinghe, NL; Wilson, KJ; Zhang, M; Zhou, Z | 1 |
| Atack, JR; Bromidge, FA; Broughton, HB; Chambers, MS; Cook, S; Dawson, GR; Hobbs, SC; MacLeod, AM; Maubach, KA; Reeve, AJ; Seabrook, GR; Wafford, K | 1 |
| Dalvie, DK; Kalgutkar, AS; Khojasteh-Bakht, SC; O'Donnell, JP; Obach, RS | 1 |
| Balachandran, R; Day, BW; Reeves, JT; Wipf, P | 1 |
| Lee, KG; Ochi, H; Shibamoto, T; Yanagimoto, K | 1 |
| Anglard, P; Bonnafous, S; Chavey, C; Mari, B; Monthouel, MN; Tartare-Deckert, S; Van Obberghen, E | 1 |
| Alegria, L; Cortés, MJ; Fillion, H; Pautet, F; Pessoa, CD; Salas, C; Sarciron, ME; Tapia, RA; Valderrama, JA; Walchshofer, N | 1 |
| Atack, JR; Broughton, HB; Chambers, MS; Collinson, N; Cook, S; Dawson, GR; Hobbs, SC; MacLeod, AM; Marshall, G; Maubach, KA; Pillai, GV; Reeve, AJ | 1 |
| Maubach, K | 1 |
| GARCIAMATAMOROS, E | 1 |
| LAX, SR; RAVEL, JM; SHIVE, W; SMITH, LC | 1 |
| Bar-Ner, N; Brandeis, R; Egozi, I; Fisher, A; Haring, R; Kliger-Spatz, M; Marcovitch, I; Natan, N; Pittel, Z; Sonego, H | 1 |
| Fang, D; Liu, Q; Xu, X; Zheng, J | 1 |
| Ali, F; Bone, RF; Crysler, CS; Cummings, MD; DesJarlais, RL; Illig, CR; Jonathan Rudolph, M; Khalil, E; Kilpatrick, JM; Klein, S; Morris, PE; Soll, RM; Spurlino, JC; Subasinghe, NL; Sudhakara Babu, Y | 1 |
| Ikeda, T; Kinoshita, M; Masui, K; Mori, A; Okano, K; Takamura, K | 1 |
| Acevedo, O; Carter, L; Chen, C; Connors, PJ; Fisher, A; Gross, TD; Guo, Z; Moorjani, M; Rowbottom, MW; Saunders, J; Struthers, RS; Sullivan, SK; Tucci, FC; Xie, Q; Zhu, YF | 1 |
| Hoa Ok, J; Kim, BH | 1 |
| Chun, SJ; Jeon, JJ; Joe, GH; Kim, DS; Lee, SW | 1 |
| Ananthanarayanan, VS; Atkinson, HM; Thomson, CA | 1 |
| Chun, SJ; Kim, DS; Roberson, RW; Uchida, M | 1 |
| Tran, K; Young, D; Zeng, EY | 1 |
| Beukers, MW; de Grip, WJ; Ijzerman, AP; Klaasse, EC; Roerink, SF; van den Hout, G | 1 |
| Baron, O; Ila, H; Knochel, P; Wagner, AJ | 1 |
| Fischer, G; Lausecker, B | 1 |
| Sharaby, CM | 1 |
| Cashman, JR; Cerny, MA; Denton, TT; Johnson, EF; Yano, JK; Zhang, X | 1 |
| de Lera, AR; Furst, A; Germain, P; Gronemeyer, H; Iglesias, B; Pereira, R | 1 |
| Fischer, L; Franke, L; George, S; Hoernig, C; Müller-Kuhrt, L; Schneider, G; Schneider, P; Schwarz, O; Steinhilber, D; Tanrikulu, Y; Werz, O | 1 |
| Ganeshapillai, D; Potter, BV; Purohit, A; Reed, MJ; Smith, A; Su, X; Vicker, N | 1 |
| Bratton, L; Cheng, XM; Erasga, N; Filzen, GF; Geyer, A; Lee, C; Lu, G; Pulaski, J; Sorenson, RJ; Trivedi, BK; Unangst, PC; Xu, X | 1 |
| Auge, N; Coatrieux, C; Hannun, Y; Itohara, S; Negre-Salvayre, A; Parini, A; Salvayre, R; Sanson, M | 1 |
| Fisher, PW; Hofmann, GA; Janson, CA; Johnson, RK; Kirkpatrick, RB; Ma, C; Marino, JP; Mattern, M; Meek, TD; Ryan, MD; Schulz, C; Smith, WW; Tew, DG; Thompson, SK; Tomazek, TA; Veber, DF; Xiong, WC; Yamamoto, Y; Yamashita, K; Yang, G | 1 |
| Chappell, AS; D'Souza, DN; Iyengar, S; Pritchett, YL; Raskin, J; Smith, TR; Wang, F; Wernicke, JF | 1 |
| Billin, AN; Grillot, DA; Iannone, MA; Lazar, MA; Lobe, DC; Shearer, BG; Stanley, TB; Steger, DJ; Way, JM; Willson, TM | 1 |
| Doucet, H; Roger, J | 1 |
| Humphreys, WG; Josephs, JL; Li, W; Skiles, GL | 1 |
| Ayida, B; Bartkowski, DM; Blazel, J; Ellis, D; Gobbi, A; Han, Q; Kim, SH; Kirkovsky, L; Kissinger, CR; LeBrun, LA; McGuire, H; Murphy, DE; Nolan, TG; Norris, DA; Patel, R; Ruebsam, F; Sergeeva, MV; Shah, AM; Showalter, RE; Tran, CV; Tran, MT; Tsan, M; Webber, SE; Xiang, AX; Zhao, Q; Zhou, Y | 1 |
| Abe, M; Fukushima-Shintani, M; Hirayama, F; Iwatsuki, Y; Kawasaki, T; Sugasawa, K; Suzuki, K | 1 |
| Botta, M; Crespan, E; Falchi, F; Maga, G; Manetti, F; Schenone, S | 1 |
| Abe, M; Fukushima-Shintani, M; Hirayama, F; Iwatsuki, Y; Kawasaki, T; Nakahata, T; Sugasawa, K; Suzuki, K | 1 |
| Baer, T; Beckers, T; Ciossek, T; Dove, S; Eichhorn, E; Mahboobi, S; Maier, T; Pongratz, H; Sellmer, A; Winkler, M | 1 |
| Nurden, AT; Nurden, P; Viallard, JF | 1 |
| Bussel, JB; Cohn, CS | 1 |
| Berghot, MA; Gouda, MA; Khalil, AM | 1 |
| Hartman, J; Jia, Z; McCormick, CD; Nolen, BJ; Pierce, DW; Pollard, TD; Russell, A; Sakowicz, R; Tomasevic, N | 1 |
| Eikelboom, J; O'Donnell, M; Sobieraj-Teague, M | 1 |
| Baralatei, FT; Lauterbach, EC | 1 |
| Bey, E; Birk, B; Frotscher, M; Hartmann, RW; Klein, T; Kruchten, P; Marchais-Oberwinkler, S; Negri, M; Oster, A; Spadaro, A; Werth, R | 1 |
| Duarte, J; Galindo, P; Gómez-Guzmán, M; Haro, JM; Jiménez, R; López-Sepúlveda, R; Pérez-Vizcaíno, F; Quintela, AM; Romero, M; Sánchez, M; Zarzuelo, A; Zarzuelo, MJ | 1 |
| Bramanti, P; Cuzzocrea, S; Di Paola, R; Esposito, E; Galuppo, M; Kapoor, A; Mazzon, E; Paterniti, I; Thiemermann, C | 1 |
| Alvarez-Guardia, D; Barroso, E; Coll, T; Gómez-Foix, AM; Laguna, JC; Palomer, X; Vázquez-Carrera, M | 1 |
| Fang, CJ; Feng, W; Li, ZX; Liao, LY; Sun, LD; Sun, W; Xu, CH; Yan, CH; Zhang, C; Zhang, YW; Zhou, HP | 1 |
| Abalos, T; Calero, P; García-Acosta, B; Martínez-Máñez, R; Raposo, MM; Ros-Lis, JV; Soto, J | 1 |
| Alajarin, M; Bonillo, B; Sanchez-Andrada, P; Vidal, A | 1 |
| Lopes, RD; Mahaffey, KW; Piccini, JP | 1 |
| Bahrami, S; Bishop-Bailey, D; Busch, D; Castiglia, S; Collino, M; Desvergne, B; Fantozzi, R; Kapoor, A; Mitchell, JA; Mota-Filipe, H; Osuchowski, MF; Patel, NS; Sepodes, B; Shintani, Y; Suzuki, K; Thiemermann, C; Yaqoob, MM | 1 |
| Johnson, AP | 1 |
| Hiroe, K; Kawamura, M; Konishi, N | 1 |
| Harries, M; Ward, SE | 1 |
| Baraldi, PG; Borea, PA; Gessi, S; Merighi, S; Romagnoli, R; Tabrizi, MA | 1 |
| Aggarwal, S; Bhardwaj, TR; Kumar, M; Thareja, S | 1 |
| Andrade, CD; Belfield, KD; Bondar, MV; Hernandez, FE; Przhonska, OV; Yanez, CO | 1 |
| Abe, M; Hirayama, F; Itoh, H; Kawasaki, T; Koga, Y; Naganuma, S; Sakata, C; Sugasawa, K; Suzuki, K | 1 |
| Frotscher, M; Hartmann, RW; Hinsberger, S; Marchais-Oberwinkler, S; Oster, A; Werth, R | 1 |
| Artis, DR; Bard, F; Bowers, S; Brogley, L; Fang, L; Griswold-Prenner, I; Hom, RK; Konradi, AW; Neitz, RJ; Neitzel, ML; Pan, H; Powell, K; Probst, GD; Quinn, K; Ren, Z; Sauer, JM; Sealy, JM; Sham, HL; Tóth, G; Truong, AP; Wu, J; Yao, N; Yednock, TA | 1 |
| Al-Qasoumi, SI; Al-Said, MS; Bashandy, MS; Ghorab, MM | 1 |
| Fleita, DH; Mohareb, RM; Sakka, OK | 1 |
| Weitz, JI | 1 |
| Eikelboom, JW; Eriksson, BI; Quinlan, DJ | 1 |
| Correia, IJ; de Sousa, HC; Gaspar, MN; Gil, MH; Natu, MV; Ribeiro, CA; Silva, D | 1 |
| Itami, K; Kirchberg, S; Studer, A; Tani, S; Ueda, K; Yamaguchi, J | 1 |
| Boos, J; Lanvers-Kaminsky, C; Spaniol, K | 1 |
| Keltai, K; Keltai, M | 1 |
| Helal, MH; Mahmoud, Ael-S; Mohareb, RM; Shams, HZ | 1 |
| Di Pasquale, G; Riva, L | 1 |
| Breen, KA; Hunt, BJ | 1 |
| Amer, FA; Badawy, DS; Bayoumy, NM; Berghot, MA; Fadda, AA | 1 |
| Brussee, J; Heitman, LH; Ijzerman, AP; Kleinau, G; Krause, G | 1 |
| Nagao, T | 1 |
| Asano, M; Doi-Komuro, H; Inoue, R; Kagari, T; Kaneko, R; Kawase, Y; Koga, T; Masubuchi, N; Mizuno, Y; Nakamura, T; Nakayama, S; Namba, E; Nara, F; Nasu, H; Nishi, T; Oguchi-Oshima, K; Sekiguchi, Y; Shimozato, T; Tamaki, K; Tomisato, W; Yamaguchi, T; Yuita, H | 1 |
| Cohen, AT | 1 |
| Clarke, NN; Fone, KC; Layfield, R; Woods, S | 1 |
| Aghazadeh Tabrizi, M; Baraldi, PG; Basso, G; Bortolozzi, R; Brancale, A; Fu, XH; Hamel, E; Li, J; Porcù, E; Preti, D; Romagnoli, R; Salvador, MK; Viola, G; Zhang, SZ | 1 |
| Bommer, WJ | 1 |
| Al-Majid, AM; Al-Nahary, TT; Alamary, AS; Barakat, A; Mabkhot, YN | 1 |
| Halperin, JL; Varughese, CJ | 1 |
| Aarts, M; Ashworth, A; Garcia-Murillas, I; Gevensleben, H; Hurd, MS; Sharpe, R; Shumway, SD; Toniatti, C; Turner, NC | 1 |
| Gallagher, M; Koh, MT; Rosenzweig-Lipson, S | 1 |
| Al-Said, MS; Ghorab, MM | 1 |
| Douketis, JD; Gerotziafas, G; Kaatz, S; Ortel, TL; Schulman, S; Spyropoulos, AC | 1 |
| Brenner, B; Hoffman, R | 1 |
| Jung, SH; Ryu, WS; Sun, X; Yang, BS | 1 |
| Ashour, RM; Elmegeed, GA; Mohareb, RM; Wardakhan, WW | 1 |
| Al-Omran, F; Mohareb, RM | 1 |
| Li, RM; Liu, ZW; Wang, C; Zhao, B | 1 |
| Koziński, M; Kubica, A; Kubica, J; Navarese, EP; Obońska, K | 1 |
| Valle Bernad, R | 1 |
| Kaatz, S; Mahan, CE | 1 |
| Basciano, PA; Bussel, J; Christos, PJ; Giannakakou, P; Hafeez, Z | 1 |
| Martin, EN; Money, SR; Shamoun, FE | 1 |
| Graff, J; Harder, S | 1 |
| Nieto Rodríguez, JA | 1 |
| Evans, RM; Martin, HL; Mounsey, RB; Mustafa, S; Nelson, MC; Sathe, K; Teismann, P | 1 |
| Bostancıoğlu, RB; Demirel, S; Koparal, AT; Turgut Cin, G | 1 |
| Bauer, Y; Bolli, MH; Gatfield, J; Killer, N; Menyhart, K; Nayler, O; Renault, B; Sobel, K; Steiner, B; Studer, R | 1 |
| Badimón, JJ; Briongos Figuero, S; García Santos-Gallego, C | 1 |
| Arachchillage, DJ; Cohen, H | 1 |
| Spyropoulos, AC; Turpie, AG | 1 |
| Capozzi, ME; McCollum, GW; Penn, JS; Savage, SR | 1 |
| Baruch, L | 1 |
| Lopes, RD; Newby, LK; Truffa, AA | 1 |
| Agnelli, G; Becattini, C; Franco, L | 1 |
| Majeed, A; Schulman, S | 1 |
| Bushmarinov, IS; Fedorov, AE; Larionova, NA; Mortikov, VY; Rodinovskaya, LA; Shestopalov, AM; Zubarev, AA | 1 |
| Schulman, S | 2 |
| Fadda, AA; Refat, HM | 1 |
| Bordignon-Luiz, MT; Burin, VM; de Revel, G; Marchand, S | 1 |
| Gong, M; Lu, Y; Mao, T; Tong, N; Tong, Y; Wang, C; Yang, Q; Yang, Y; Zhou, M | 1 |
| Dekkers, OM; den Exter, PL; Huisman, MV; Klok, FA; Kooiman, J; van der Hulle, T | 1 |
| Koganezawa, T; Osaka, I; Saito, M; Takimiya, K | 1 |
| Rondina, MT; Vazquez, S; Vo, T | 1 |
| Bourgault, S; De Carufel, CA; Forgione, P; Hassanpour, A | 1 |
| Giugliano, RP; Gonzalez-Quesada, CJ | 1 |
| Bounameaux, H; Fontana, P; Goldhaber, SZ | 1 |
| Chan, NC; Eikelboom, JW; Ginsberg, JS; Hirsh, J; Lauw, MN; Paikin, JS | 1 |
| Larsen, TB; Lip, GY; Rasmussen, LH; Skjøth, F | 1 |
| Chen, X; He, Q; Huang, X; Xie, Y; Yang, C | 1 |
| Bao, XC; Fang, YQ; Ma, J; You, P; Zhang, S | 2 |
| Meddahi, S; Samama, MM | 1 |
| Arya, R; Couchman, L; Flanagan, RJ; Gous, T; Paradzai, C; Patel, JP | 1 |
| Davidson, N; Galloway, SW; Lai, A; Thachil, J | 1 |
| Aledort, LM; Bussel, JB; Cuker, A; Kessler, CM; Kuter, DJ; McIntosh, J; Pendergrass, KB; Tang, S | 1 |
| Dempfle, CE | 1 |
| Prandoni, P; Taher, A; Temraz, S | 1 |
| Beer, JH; Holy, EW | 1 |
| Hürlimann, D; Noll, G; Noll, S | 1 |
| Geng, Y; Liu, L; Su, Z; Tang, X; Wu, Y; Yang, G | 1 |
| Bieberich, E; Bryant, L; Chen, C; Chen, Z; Cuzzocrea, S; Doyle, T; Esposito, E; Janes, K; Kamocki, K; Li, C; Little, JW; Neumann, WL; Nicol, G; Obeid, L; Petrache, I; Salvemini, D; Snider, A | 1 |
| Corelli, K; Ezekowitz, MD; Ghosh, P; Spahr, J | 1 |
| Freeman, K; Jayson, S; Maggs, DJ; Petritz, O; Sanchez-Migallon Guzman, D | 1 |
| Gross, PL; Weitz, JI; Yeh, CH | 1 |
| Dash, RP; Nivsarkar, M; Pandya, AN; Patil, D; Thakur, SK; Vasu, KK; Venkatesh, P | 1 |
| Galatou, E; Kelly, T; Lazou, A | 1 |
| Kakkos, SK; Kirkilesis, GI; Tsolakis, IA | 3 |
| Angeli, F; Lip, GY; Reboldi, G; Verdecchia, P | 1 |
| Büller, HR; Coppens, M; Middeldorp, S; Schulman, S; van Es, N | 1 |
| Gómez-Outes, A; Lecumberri, R; Suárez-Gea, ML; Terleira-Fernández, AI; Vargas-Castrillón, E | 1 |
| González-Curbelo, MÁ; Hernández-Borges, J; Lehotay, SJ; Rodríguez-Delgado, MÁ | 1 |
| Hassanein, T; Howell, CD; Jenkins, TM; Joshi, S; Lake, J; McIntosh, J; Sher, L; Tang, S; Terrault, NA; Vargas, H | 1 |
| Adomat, H; Ban, F; Cherkasov, A; Dalal, K; Frewin, K; Leblanc, E; Li, H; Ma, D; Rennie, PS | 1 |
| Amin, A; Graham, J; Jing, Y; Lin, J; Lingohr-Smith, M; Trocio, J | 1 |
| Mitchell, AR; Page, PL; Thomas, R | 1 |
| Bongu, NR; Kocheril, AG; Turagam, MK; Velagapudi, P | 1 |
| Bang, OY; Chung, CS; Kim, GM; Kim, JS; Kim, SJ; Lee, KH; Lee, MJ; Park, YK; Ryoo, S; Yoon, CH | 1 |
| Hunt, BJ; Sciascia, S | 1 |
| Meddahi, S; Samama, CM; Samama, MM | 1 |
| Lane, DA; Lip, GY; Senoo, K | 1 |
| Bissonnette, J; Rautou, PE; Valla, D | 1 |
| Giugliano, RP; Plitt, A | 1 |
| Madhusudhana, S; Qasem, A; Strasser, KM | 1 |
| Fadda, V; Maratea, D; Marinai, C; Messori, A; Trippoli, S | 1 |
| Dobesh, PP; Fanikos, J | 1 |
| Ezekowitz, MD; Kent, AP | 1 |
| Le, G; Shi, Y; Wang, F; Yang, W | 1 |
| Chekkara, R; Gorla, VR; Susithra, E; Tenkayala, SR | 1 |
| Baber, U; Mastoris, I; Mehran, R | 1 |
| Hodges, MR; Ottosen, S; Parsley, TB; Patick, AK; Raney, AK; van der Veer, E; van Doorn, LJ; Yang, L; Zeh, K | 1 |
| Chatterjee, S; Ghosh, J; Giri, JS; Lavie, CJ; Lip, GY; Mukherjee, D; Sardar, P | 1 |
| Davis, EM; Schardt, GL; Schmidt, DP; Uhlmeyer, EM | 1 |
| Boubaker, G; Gorgas, D; Gottstein, B; Hemphill, A; Müller, J; Müller, N; Rufener, R; Spiliotis, M; Stadelmann, B | 1 |
| Peerlinck, K; Vanassche, T; Vandenbriele, C; Verhamme, P | 1 |
| Giannoukas, AD; Spanos, K | 1 |
| Blann, AD | 1 |
| Arepally, GM; Ortel, TL | 1 |
| Ansell, JE; Cabral, KP | 1 |
| Jalani, HB; Kachler, S; Klotz, KN; Pandya, AN; Pandya, DH; Sharma, JA; Sudarsanam, V; Vasu, KK | 1 |
| Oberhofer, E | 1 |
| Powell, JR | 1 |
| Abbas, NS; Mohareb, RM; Zaki, MY | 1 |
| Hogg, K; Weitz, JI; Yeh, CH | 1 |
| Chang, HH; Chen, CH; Lee, AS; Lin, YC | 1 |
| Lane, DA; Wood, K | 1 |
| Handa, A; Hurst, KV; Lee, R; Milosevic, I | 1 |
| Andersson, KE; Boedtkjer, DM; Jensen, AB; Kim, S; Matchkov, VM | 1 |
| Arul Antony, S; Balachandran, C; Shahavar Sulthana, S; Syed Shafi, S | 1 |
| Abdalla, DS; Brüne, B; Cavalcante, MF; Finkernagel, F; Kemmerer, M; Müller, R; Namgaladze, D | 1 |
| Cogolludo, Á; Duarte, J; Gálvez, J; Gómez-Guzmán, M; Hermenegildo, C; Jiménez, R; Pérez-Vizcaíno, F; Romero, M; Toral, M; Utrilla, MP; Zarzuelo, MJ | 1 |
| Barroso, E; Briones, AM; Cogolludo, Á; Duarte, J; García-Redondo, AB; Gómez-Guzmán, M; Jiménez, R; Mahmoud, AM; Pérez-Vizcaíno, F; Romero, M; Sánchez, M; Toral, M; Vázquez-Carrera, M | 1 |
| Andel, M; Malisova, L; Trnka, J; Tumova, J | 1 |
| Jin, X; Lei, C; Zhou, JS | 1 |
| Do, JT; Ham, SA; Han, CW; Hwang, JS; Kim, JH; Lee, WJ; Oh, JW; Paek, KS; Seo, HG; Yoo, T | 1 |
| Laher, I; Li, S | 1 |
| de Knegt, RJ; Maan, R; Veldt, BJ | 1 |
| Carlsson, J; Hill, SJ; Ranganathan, A; Stoddart, LA | 1 |
| Hu, YH; Ren, WM; Tang, XC; Xu, MM; Zhang, HY | 1 |
| Brockschnieder, D; Chi, DY; Chu, SY; Dyrks, T; Kim, JS; Kwon, HR; Lee, BS; Oh, SJ; Park, C; Sirion, U | 1 |
| Desantis, J; Goracci, L; Massari, S; Tabarrini, O | 1 |
| Duarte, J; Jiménez, R; Martínez, MC; Pérez-Vizcaíno, F; Robles-Vera, I; Romero, M; Tamargo, J; Toral, M | 1 |
| Dessy, C; Duarte, J; Gómez-Gúzman, M; Jiménez, R; León-Gómez, E; Pérez-Vizcaíno, F; Rath, G; Rodríguez-Gómez, I; Romero, M; Sánchez, M; Tamargo, J; Toral, M; Zarzuelo, MJ | 1 |
| Al-Dosari, MS; Al-Mishari, AA; Almoqbil, AN; Alsaid, MS; Ghorab, MM; Ragab, FA | 1 |
| Agarwal, AK; Garg, A; Sankella, S | 1 |
| Altalbawy, FM; Edrees, MM; Gomha, SM | 1 |
| Gao, J; Guan, L; Song, Y; Wang, K | 1 |
| Appelqvist, H; Bäck, M; LeVine, H; Nilsson, KP | 1 |
| Asiedu, MN; Dib-Hajj, SD; Dussor, G; Han, C; Price, TJ; Waxman, SG | 1 |
| Alam, MJ; Bassères, E; Dotson, KM; Endres, BT; Garey, KW | 1 |
| Aluri, J; Ferry, J; Han, D; Nomoto, M; Pastino, G; Rege, B | 1 |
| Agarwal, M; Digwal, CS; Pandya, AN; Pandya, DH; Patel, S; Sharma, JA; Vasu, KK | 1 |
| Aluri, J; Boyd, P; Chang, MK; Ferry, J; Lai, WG; Nomoto, M; Rege, B; Schuck, E; Siu, YA; Yasuda, S; Zamora, CA | 1 |
| Ali, HI; Ali, J; Deba, F; Hamouda, AK; Ramos, K; Tairu, A | 1 |
| Abdallah, AEM; Mohamed, AA; Mohareb, RM | 1 |
| Kantevari, S; Marvadi, SK; Sriram, D; Surineni, G; Yogeeswari, P | 1 |
| Bahrami, S; Busch, D; Hildebrand, F; Kapoor, A; Osuchowski, MF; Rademann, P; Thiemermann, C | 1 |
| Dao, LTM; Spicuglia, S | 1 |
| Ferry, J; Hussein, Z; Nomoto, M | 1 |
| Al-Samkari, H; Kuter, DJ | 1 |
| Shirley, M | 1 |
| Lee, C; Robinson, M; Willerth, SM | 1 |
| Chang, WT; Chen, ZC; Cheng, JT; Cheng, KC; Cheng, YZ; Li, Y | 1 |
| Aschenbrenner, DS | 1 |
| Guo, ZK; Ma, KT; Si, JQ; Tian, XQ; Wang, XW; Wang, Y | 1 |
| Allen, LF; Kuter, DJ | 1 |
| Carmichael, SL; Forde, EE; Frelinger, AL; Michelson, AD; Smolensky Koganov, E | 1 |
| Atta-Allah, SR; El-Mawgoud, HKA; Hemdan, MM | 1 |
| Bussel, JB | 1 |
| Weinberg, EM | 1 |
| Ahmad, KS | 1 |
| Al-Samkari, H | 1 |
| Choi, S; Hong, C; Jiao, HY; Jun, JY; Kang, HG; Shin, DH; Wu, MJ | 1 |
| Długosz-Danecka, M; Jurczak, W; Zdziarska, J | 1 |
| Chilvers, MI; Noel, ZA; Roth, MG; Sang, H | 1 |
| Liu, J; Tian, Y; Wang, N; Xiao, L; Xie, X; Yang, C; Yao, Q; Zhang, Z | 1 |
| Al-Horani, RA; Clemons Bankston, P | 1 |
| Berglund, E; Bränström, R; Fröbom, R; Larsson, C; Lui, WO; Nilsson, IL; Sellberg, F; Xu, C; Zhao, A | 1 |
| Abdo, NYM; Al-Darkazali, WN; Mohareb, RM | 1 |
| Cooper, SL; Hill, SJ; Jörg, M; March, J; Sabbatini, AR; Scammells, PJ; Woolard, J | 1 |
| Bekier, A; Cytarska, J; Dzitko, K; Płaziński, W; Rosada, B; Sikora, A; Zavyalova, O; Łączkowski, KZ | 1 |
| Hussar, DA | 1 |
| Crippa, A; Davis, JM; Leucht, S; Orsini, N; Patel, MX; Siafis, S | 1 |
| Broder, MS; Chang, E; Greene, M; Houle, CR; Tarbox, MH; Waters, HC; Yan, T | 1 |
| Chen, Y; Fan, T; Guo, W; Hu, P; Liu, M; Shao, T; Yi, Z; Zhou, W | 1 |
| Dorrance, AE; Eyre, M; McDuffee, D; Scott, K | 1 |
| Hirao-Suzuki, M; Koga, T; Takeda, S; Takiguchi, M; Toda, A | 1 |
| Abbasnezhad, A; Abd El-Ghafar, OA; Abhilash, L; Abouzid, KAM; Achberger, AM; Ackerman, S; Akhatayeva, Z; Akin, D; Al-Kaysi, RO; Alakhdar, AA; Alame, M; Aleksic Sabo, V; Alinezhadbalalami, N; Allen, JD; Alonso, JM; Alqatani, S; Alsayed, B; Álvarez Larraondo, M; Alvarez, M; Amini, SB; An, Z; Anasir, MI; Anderson, GH; Andremont, A; Andrés, S; Angel, S; Anigboro, AA; Anini, Y; Antonides, CFJ; Arafa, K; Arafa, RK; Aryal, UK; Asbaghi, O; Assefa, MK; Atyah, M; Avwioroko, OJ; Ayora-Talavera, G; Azpilikueta, A; Azyazov, VN; Ba, YF; Bachmann, KF; Badoual, J; Bae, SJ; Baek, SH; Bahrami, B; Bai, J; Baid-Agrawal, S; Bailey, MR; Baillie, JK; Balani, N; Balcar, VJ; Banica, T; Banks, L; Barb, J; Bardeen, CJ; Barrett, HE; Bartnikowski, N; Bashir, R; Battaglia, M; Bautista-Hernández, V; Becker, B; Beekman, FJ; Benidir, M; Benjelloun, M; Bentley, RF; Bergé, J; Berger, D; Bernsen, MR; Berraondo, P; Bhattacharya, R; Bhayani, SB; Bi, W; Bi, X; Bi, YL; Bi, Z; Bian, K; Biesecker, LG; Billadeau, DD; Blaszczyk, R; Blum, JL; Boachie, R; Boelte, K; Bogers, AJJC; Boileau, I; Bonduelle, C; Bonny, O; Bonsu, JM; Boos, LA; Borges-Argáez, R; Bouchard, PA; Boudot, C; Bourgeade-Delmas, S; Boutet-Robinet, E; Boyle, AJ; Branigan, D; Briones, S; Broniowska, KA; Brossas, JY; Brown, WA; Brzezinska, J; Buitron, G; Burnier, M; Bursulaya, B; Burton, PR; Bush, AA; Busuttil, RW; Cabello-Aguilar, S; Cáceres-Farfán, M; Cacheux, V; Caffrey, PJ; Cai, B; Cai, Q; Cai, S; Cai, Y; Calders, P; Cammarota, G; Campbell, DA; Cancelli, C; Cao, Q; Cao, WH; Cao, X; Capet, M; Capoluongo, E; Carey, ME; Carnero, M; Carrasco, LI; Carreno, J; Carrillo-Reyes, J; Casini, I; Cassar, M; Catalan, G; Cattamanchi, A; Cazares-Granillo, M; Celie, B; Cen, YK; Cena, H; Cerbo, RM; Ceron, E; Cetina-Montejo, L; Chaâbane-Banaoues, R; Chabanet, C; Chace-Donahue, F; Chalfun-Júnior, A; Chan-Balan, R; Chang, CS; Chen, CS; Chen, D; Chen, J; Chen, L; Chen, PN; Chen, Q; Chen, S; Chen, W; Chen, WP; Chen, X; Chen, Z; Cheng, H; Cheng, J; Cheng, Q; Cheng, T; Chi, T; Chianelli, D; Chieppa, M; Child, CJ; Cho, JH; Cho, JY; Chogtu, B; Choi, GH; Choi, J; Choi, M; Choi, NG; Cholu, CO; Chow, ES; Chowdhury, AH; Chu, PC; Chu, Q; Chu, S; Chua, H; Chung, T; Chunyan, L; Church, JS; Civardi, E; Cobiella, J; Colinge, J; Collado, CJ; Collins, TJ; Cong, LM; Conkrite, KL; Cope, SJ; Corbett, JA; Cornet, M; Cornillot, E; Corvaisier, S; Costes-Martineau, V; Courtioux, B; Coussens, M; Covino, M; Criado, A; Cui, J; Cui, Y; Cunitz, BW; Curry, AE; Cussó, L; D'Urzo, AD; D'Urzo, KA; Dabbous, S; Dahlgren, RA; Dai, H; Dai, T; Dai, W; Dalinghaus, M; Dang, S; Davalos, RV; Davidson, H; de Andrea, CE; De Angelis, M; de Blois, E; de Carvalho, PA; De Clercq, E; De Giuseppe, R; de Jong, M; De Langhe, S; De Oliveira, L; de Souza Pinto Lemgruber, R; de Souza, LB; de Swart, J; De Wandele, I; de Woestijne, PCV; Delaney, S; Delorme, M; Delvenne, P; Deng, L; Deng, Z; Denkinger, CM; der Meulen, MHV; Deraeve, C; Desco, M; DeSilva, S; Destere, A; Dhali, A; Di Ciano, P; Dias-Santagata, D; Diskin, SJ; Djè, MK; Doddipatla, S; Doerr, AJ; Dokla, EME; Domiciano, D; Domingo, N; Dong, C; Dong, J; Dong, Q; Dong, S; Dong, X; Dong, Z; Douair, I; Douglas, TA; Doyle, SM; Drain, PK; Du, K; Du, L; Du, Q; Du, S; Duan, C; Duan, H; Duan, J; Duan, S; Duan, W; Dueluzeau, R; Dukic, L; Dunmire, BL; Duvauchelle, T; Dymek, B; Dzwonek, K; Earnest, A; Eckardt, KU; El Ghadraoui, L; El Massoudi, S; Elloumi, F; Elnour, IE; Embarak, S; Ende, M; England, K; Enikeev, D; Enyedy, I; Epple, R; Erickson, GE; Eriksson, J; Erndt-Marino, J; Errachidi, F; Etxeberria, I; Evan, AP; Fairlamb, AH; Falahi, E; Fan, CC; Fan, H; Fan, M; Fan, MZ; Fan, S; Fan, Y; Fang, CS; Fang, J; Fang, X; Fang, Z; Farmany, A; Farooqi, A; Farouk, HO; Fazelipour, S; Feng, D; Feng, J; Feng, JX; Feng, YL; Ferraz, SL; Ferreira, CR; Figenshau, RS; Finn, AV; Fiseha, T; Fleischer, AS; Fogleman, AD; Fontaine, O; Ford, CR; Fouladvand, F; Four, M; Fousteri, G; Francis, JR; Fraser, JF; Frazier, RP; Fu, H; Fu, P; Fu, YJ; Fujishima, A; Fuster, V; Gabilan, JC; Gagliani, N; Gai, QY; Galán-Arriola, C; Gale, P; Galimova, GR; Galkin, A; Gallo, A; Gallo, AA; Gang, DD; Ganschow, S; Gao, C; Gao, F; Gao, GP; Gao, H; Gao, K; Gao, M; Gao, MY; Gao, P; Gao, R; Gao, S; Gao, WJ; Gao, Y; Garbacz, P; García Ruiz, L; Garcia, EM; Garofoli, F; Gasbarrini, A; Gattinoni, L; Gaudig, M; Gbureck, U; Ge, X; Genko, N; Gentile, GL; George, MW; Gerety, GF; Gestwicki, JE; Geusens, PP; Ghassemi, M; Giardina, JD; Giebultowicz, JM; Gifford, CA; Gijsen, FJH; Gilfillan, R; Gilson, E; Gingl, K; Giuliano, C; Glybochko, P; Goessler, W; Gofflot, S; Golab, J; Goldstein, A; Golebiowski, A; Gómez, L; Gómez-Carballo, J; Gonçalves, PEO; Gonzales, R; Gonzalez-Cotto, M; González-Fernández, D; Gonzalez-Lopez de Turiso, F; Goodman, JM; Govinda Raju, S; Grimm, J; Gross, AJ; Gruenheid, S; Gu, C; Gu, FF; Gu, S; Gu, Z; Guest, RL; Gui, C; Gui, J; Guillem, A; Guo, G; Guo, L; Guo, Q; Guo, S; Guo, SW; Guo, W; Guo, Y; Guo, YG; Guo, Z; Guretzky, JA; Haenggi, M; Hahn, MS; Hakkola, J; Halim, AA; Hampel, D; Han, B; Han, BH; Han, D; Han, G; Han, J; Han, LZ; Han, R; Han, S; Han, X; Han, Z; Handley, MA; Hanke, I; Hannongbua, S; Hao, P; Happ, JT; Hara, M; Haraux, F; Hare, JL; Harper, JD; Hartley, AM; Harvey, E; Hashimoto, K; Hassan, HM; Hautajärvi, H; Hayton, TW; He, C; He, H; He, HJ; He, WP; He, Y; He, Z; Hedrick, V; Heffernan, JK; Hegrová, J; Heidarimoghadam, R; Helms, K; Hengphasatporn, K; Henry, D; Herrmann, TRW; Hesson, T; Himmelbauer, MK; Hindle, A; Hoffmann, R; Hogg, N; Hong, KB; Hong, SK; Honjol, Y; Hood, C; Hsi, RS; Hsu, JL; Hu, B; Hu, BC; Hu, D; Hu, H; Hu, J; Hu, K; Hu, M; Hu, MK; Hu, T; Hu, W; Hu, Y; Hu, Z; Hua, S; Huang, H; Huang, J; Huang, L; Huang, M; Huang, P; Huang, X; Huang, Y; Huang, Z; Hukkanen, J; Hung, MC; Huo, X; Hyötyläinen, T; Ianiro, G; Ibanez, B; Imran, M; Ireland, S; Irwin, MS; Ishiguro, H; Jackowski, K; Jackson, C; Jacob, SI; Jahromy, MH; Jakob, SM; Jang, J; Javvaji, PK; Jefferson, KK; Jena, P; Ji, H; Jiang, F; Jiang, GH; Jiang, H; Jiang, J; Jiang, X; Jiang, Z; Jiao, J; Jiménez, A; Jin, X; Jincai, W; Jintao, X; Jo, K; Jofra, T; Johari, Y; Johnson, ACM; Jones, JH; Josephine Fauci, A; Juhl, AK; Jun, S; Kaiser, RI; Kajioka, J; Kajiyama, H; Kalliyil, A; Kalthur, SG; Kamalanathan, M; Kamaldinov, T; Kanaani, L; Kang, D; Kang, J; Kang, S; Känsäkoski, P; Kaplan, DL; Karwan, M; Kasibhatla, S; Kaur, A; Kawazoe, Y; Ke, C; Keyser, J; Khalique, A; Khan, IT; Kharshoum, RM; Kher, R; Kherani, J; Ki, KK; Kikkawa, F; Kikkawa, R; Kim, BT; Kim, EH; Kim, GA; Kim, GD; Kim, HB; Kim, HG; Kim, JS; Kim, MJ; Kim, SI; Kim, SJ; Kim, Y; King, K; Kinyamu-Akunda, J; Kirkkala, T; Kjaer-Sorensen, K; Kleppinger, EL; Kloner, RA; Klopfenstein, TJ; Knappe, D; Knezevic, P; Kobos, LM; Kohli, M; Kolano, L; Kolodgie, FD; Kolte, AP; Koneru, B; Kong, D; Kong, F; Kong, X; Konggidinata, MI; Köpke, M; Koski, KG; Kotsis, F; Köttgen, A; Kouakou-Kouamé, CA; Kraemer, US; Krane, V; Krehbiel, CR; Krenning, BJ; Kretzschmar, D; Ku, KB; Kubota, Y; Kulich, P; Kumar, NG; Kupiec-Weglinski, JW; Lalani, SS; Lan, X; Landfeldt, E; Langenberg, E; Lapauw, B; Larkin, J; Lassoued, MA; Laukhtina, E; Laura Martinez, J; Laveillé, A; Lavela, P; Law, AD; Lazraq, A; Le Foll, B; Lee, BK; Lee, C; Lee, CS; Lee, EJ; Lee, EY; Lee, G; Lee, HY; Lee, JH; Lee, JJ; Lee, JO; Lee, JS; Lee, R; Lei, H; Lei, P; Lellouche, F; Lennerz, JK; Leong, W; Leslie, I; Lessem, E; Levin, M; Levinger, I; Li, C; Li, CW; Li, CX; Li, CY; Li, D; Li, H; Li, HM; Li, J; Li, L; Li, LM; Li, N; Li, S; Li, W; Li, X; Li, XX; Li, Y; Li, Z; Li, ZL; Li, ZX; Lian, Q; Liang, C; Liang, GH; Liang, H; Liang, J; Liang, X; Liao, CX; Liao, R; Ličbinský, R; Lim, YS; Lima, HK; Lin, JG; Lin, L; Lin, S; Lin, WP; Lin, Z; Liso, M; Liu, BX; Liu, C; Liu, H; Liu, J; Liu, M; Liu, Q; Liu, S; Liu, SF; Liu, SL; Liu, T; Liu, W; Liu, X; Liu, XB; Liu, Y; Liu, YY; Liu, Z; Liu, ZQ; Lobo, M; Loitzenbauer, M; López, F; Lopez, G; López, GJ; Lou, Z; Lu, IC; Lu, J; Lu, M; Lu, W; Lu, X; Lu, Y; Luhovyy, BL; Luna-Abanto, J; Luo, J; Luo, K; Luo, L; Luo, M; Luo, W; Luo, X; Luo, XM; Lv, Y; Lv, YQ; Lyu, HD; Lyu, J; Ma, C; Ma, G; Ma, L; Ma, Q; Ma, X; Ma, Y; Macha, SJ; MacLean, E; Mahalapbutr, P; Maina, T; Malfait, F; Malfertheiner, MV; Malzert-Fréon, A; Mansouri, E; Mao, C; Marcellin, E; Marchiori, PER; Marcotte, DJ; Maréchal, A; Maric, N; Maris, JM; Maron, L; Marti, CN; Martínez-Milla, J; Mateo, J; Mather, K; Mathison, CJN; Matthay, MA; Maxwell, CL; Mazier, D; Mazumder, D; Mazurkiewicz, M; Mazzucchelli, TG; McAuley, DF; Mccoy, K; McVicar, DW; Mebel, AM; Mech, A; Meester, EJ; Meiselbach, H; Melero, I; Ménard, G; Meng, X; Mengya, Y; Merle, G; Meunier, B; Mfarrej, B; Mi, K; Migueliz, I; Mikuška, P; Miladi, K; Miletich, R; Millar, JE; Mills, MR; Milne, R; Minute, L; Misiak, M; Mo, F; Modi, A; Mok, F; Molina, C; Mollen, CJ; Molteni, V; Montalto, M; Montet, D; Monti, MC; Moor, MB; Moravec, P; Morsiani, C; Murillo, E; Murugan, P; Muslem, R; Myers, RK; N'guessan, FK; Nabil, H; Nadal, J; Nadeem, M; Nafady, MM; Nafie, MS; Nair, HP; Nakano, R; Nance, J; Naren, N; Neil, CJ; Nelson, J; Nery, FC; Netsch, C; Nguyen, TH; Ni, L; Ni, YX; Nie, W; Nielsen, LK; Nigam, K; Nikolayev, AA; Nishiyama, M; Niu, LL; Niu, PP; Nock, BA; Noer, PR; Noll, G; Noll, S; Norenberg, JP; Nowicka, J; Nutho, B; O'Connor, M; Obonyo, NG; Ochiai, T; Ochoa, MC; Oh, BL; Oh, S; Olczak, J; Olivares, X; Ommurugan, B; Oosthuizen, MC; Operario, D; Orešič, M; Oshima, K; Otano, I; Ou, Y; Owen, TW; Oxvig, C; Pacey, V; Pai, M; Paik, H; Paiva, R; Palmieri, EM; Palpant, N; Pan, L; Pan, Q; Panahi, S; Pang, B; Pang, ZC; Pannecouque, C; Paris, L; Park, D; Park, DJ; Park, E; Park, EC; Park, IH; Park, JH; Park, JI; Park, S; Passmore, MR; Pattaranggoon, NC; Paun, M; Pedersen, S; Pedron, J; Peng, M; Peng, X; Penzhorn, BL; Pérez-Camargo, D; Perez-Maldonado, R; Pérez-Vicente, C; Pham, TD; Pickering, L; Pickersgill, NA; Pinault, E; Pinotsis, N; Plan, M; Pocino, K; Poh, CL; Pons, EDC; Popoff, MR; Porri, D; Pourmand, A; Pratviel, G; Prudente, DO; Qi, H; Qi, N; Qian, LY; Qiao, L; Qiao, Q; Qin, QP; Qiu, N; Qiu, SW; Qu, F; Quan, M; Quigg, A; Raee, E; Raibaud, P; Ramanitrahasimbola, D; Rapoport, L; Rasby, RJ; Rasoanirina, BNV; Raspini, B; Ratner, JR; Razafindrakoto, Z; Redd, MA; Ren, H; Ren, N; Rey, J; Reynolds, CP; Rich, PR; Richards, CJ; Rigol, M; Rimoldi, S; Robert, P; Rodrigues, AE; Roe, JH; Rohde, S; Rokita, JL; Roland, J; Rombaut, L; Ronkainen, J; Rothenberg, SM; Roy, SC; Ruan, Z; Rucker, PV; Rueda, D; Ruhwald, M; Rungrotmongkol, T; Rupert, AS; Rusjan, P; Ryabov, AD; Rysä, J; Saad, NES; Sabioni, P; Sadow, PM; Sahai, N; Salem, HF; Salinas, B; Salonurmi, T; Samé Guerra, D; Sánchez, J; Sanchez-González, J; Sanmamed, MF; Sansores-Peraza, P; Santoro, JC; Santschi, PH; Saritas, T; Sarkisova, Y; Savolainen, MJ; Scherberich, JE; Schlom, DG; Schmelz, EM; Schmid, MC; Schneider, MP; Schumacher, S; Schwartz, JC; Schwartzer, JJ; Schwehr, K; Schweitzer, DH; Scott, ME; Sedky, NK; See Hoe, L; Sejian, V; Selvaraju, S; Sen, SK; Seo, G; Šerý, O; Settles, JA; Sfar, S; Shaffer, J; Shan, GL; Shang, Q; Shannahan, JH; Shao, B; Shao, H; Shao, J; Shao, ZH; Shasha, Y; Shaw, K; Sheeba, V; Shekar, K; Shen, G; Shen, H; Shen, XD; Shen, Y; Sherrell, PC; Shete, PB; Shi, AX; Shi, J; Shi, JH; Shi, S; Shi, X; Shigeta, Y; Shimbo, A; Shin, E; Sikka, N; Silhavy, TJ; Simanon, N; Simard, S; Simon, J; Simon, M; Simpson, SD; Simundic, AM; Since, M; Singh, B; Singhroy, DN; Sinisterra, OT; Smith, EH; Sobreira, TJP; Solanes, N; Somasundar, Y; Sommerer, C; Sonei, A; Song, B; Song, E; Song, J; Song, M; Song, Y; Soo Lee, M; Sorensen, MD; Sournia-Saquet, A; Spaepen, E; Spirk, D; Srivastava, S; Stancill, JS; Stanczak, PS; Starenki, D; Starr, F; Step, DL; Steubl, D; Stigliani, JL; Stráská, J; Sträter, N; Su, ZZ; Sudano, I; Suen, JY; Suh, HJ; Sui, ZY; Suico, JG; Suleiman, K; Sumon, K; Sun, HB; Sun, J; Sun, L; Sun, LL; Sun, M; Sun, Q; Sun, W; Sun, X; Sun, XF; Sun, Y; Sun, YB; Sun, YH; Sun, YN; Sun, Z; Sunada, K; Suzuki, S; Sylvan, JB; Takala, J; Talla, D; Tamir, Z; Tan, SJ; Tanda, S; Tang, H; Tang, J; Tang, LF; Tang, SJ; Tang, Y; Tao, FB; Tappel, R; Taratkin, M; Teijeira, Á; Tellew, JE; Thomas, AM; Thomas, SG; Thomson, SR; Tian, J; Tie, Y; Tirado, JL; Tolonen, A; Tosato, G; Tronnet, A; Tsai, S; Turtoi, A; Turtoi, E; Tvrdoňová, M; Tyagi, A; Tzou, DT; Uddin Ahmad, Z; Urias, E; Usawachintachit, M; Ustriyana, P; Utsumi, F; Vacca, M; Vaculovič, T; Vaidya, SS; Valentin, A; Valgepea, K; van den Berg, P; van den Bergh, JP; van der Heiden, K; van Gaalen, K; Van Gemert, W; van Haard, PMM; van Hest, JCM; Vecchiarelli, E; Večeřa, Z; Venkatesh, R; Verhaeghe, P; Verhagen, HJ; Vetter, JM; Vieira, D; Vilchez-Tschischke, JP; Villena-Gutierrez, R; Villoslada Terrones, V; Vital-Jacome, M; Voelkl, J; Vogel, K; Vogrin, S; Volke, D; von Bahr, V; Vysloužil, J; Wade, TL; Wagner-Gillespie, M; Walsh, SW; Wan, LJ; Wan, SP; Wang, AL; Wang, B; Wang, BY; Wang, C; Wang, D; Wang, F; Wang, H; Wang, HR; Wang, HY; Wang, J; Wang, JY; Wang, K; Wang, L; Wang, LF; Wang, P; Wang, Q; Wang, R; Wang, SF; Wang, SP; Wang, SR; Wang, T; Wang, W; Wang, WP; Wang, X; Wang, XJ; Wang, Y; Wang, YL; Wang, YN; Wáng, YXJ; Wang, Z; Wang, ZF; Wang, ZY; Waning, B; Warner, JM; Washington, SL; Watson, AK; Wei, B; Wei, C; Wei, F; Wei, X; Wei, Y; Wemhoff, AP; Wen, Z; Weng, TT; Wesdemiotis, C; Wheeler, DA; Wildner, M; Wilson, BK; Wirth, LJ; Wissler, M; Wu, F; Wu, G; Wu, J; Wu, KH; Wu, MC; Wu, P; Wu, PK; Wu, S; Wu, W; Wu, X; Wu, XP; Wu, Y; Wyatt, E; Wyllie, S; Xia, Y; Xiao, BH; Xiao, SZ; Xiao, W; Xiao, X; Xiao, Z; Xie, D; Xie, K; Xie, X; Xie, Y; Xie, YF; Xin, S; Xin, Z; Xing, Q; Xing, WQ; Xiong, D; Xiong, X; Xu, C; Xu, D; Xu, F; Xu, G; Xu, H; Xu, J; Xu, JY; Xu, L; Xu, N; Xu, W; Xu, X; Xu, Y; Xu, YM; Xue, H; Xue, J; Xue, Z; Yan, R; Yan, SQ; Yan, W; Yan, X; Yan, Z; Yang, C; Yang, D; Yang, F; Yang, FC; Yang, G; Yang, J; Yang, M; Yang, P; Yang, Q; Yang, R; Yang, S; Yang, SJ; Yang, TWW; Yang, X; Yang, Y; Yang, Z; Yao, C; Yao, L; Yao, LP; Yao, M; Yao, T; Yao, W; Yao, Y; Yaseen, T; Yazdani, V; Ye, J; Ye, S; Yerys, BE; Yi, HWL; Yi, JL; Yin, F; Yin, J; Yin, Y; Yin, Z; Yong, ZP; Yongli, S; Yoo, JS; Yoshikawa, N; You, Q; Yu, B; Yu, CQ; Yu, H; Yu, HG; Yu, J; Yu, L; Yu, Q; Yu, X; Yu, Y; Yu, YK; Yu, Z; Yuan, Q; Yuan, R; Yuan, W; Yuan, X; Yuan, Y; Zager, RA; Zagozdzon, A; Zaller, N; Zang, YP; Zappi, ME; Zelikoff, JT; Zeman, T; Zhai, X; Zhan, P; Zhang, B; Zhang, C; Zhang, G; Zhang, H; Zhang, HB; Zhang, J; Zhang, JS; Zhang, L; Zhang, M; Zhang, Q; Zhang, RX; Zhang, S; Zhang, T; Zhang, W; Zhang, WH; Zhang, X; Zhang, XX; Zhang, Y; Zhang, YQ; Zhang, YW; Zhang, Z; Zhang, ZH; Zhao, D; Zhao, FL; Zhao, K; Zhao, L; Zhao, M; Zhao, R; Zhao, S; Zhao, W; Zhao, WG; Zhao, X; Zhao, Y; Zheng, G; Zheng, J; Zheng, S; Zheng, W; Zheng, Y; Zheng, YG; Zhong, Z; Zhou, C; Zhou, D; Zhou, H; Zhou, HY; Zhou, L; Zhou, Q; Zhou, X; Zhou, Y; Zhou, YL; Zhou, Z; Zhu, J; Zhu, L; Zhu, N; Zhu, X; Zhu, XF; Zhu, Y; Zhu, Z | 1 |
| Berga, SL; Man, M; Rajakumar, A; Sidell, N; Taylor, RN; Yu, J; Zou, W | 1 |
| Flamm, SL; Nilles, KM | 1 |
| Gilreath, JA; Lim, MY | 1 |
| Calton, MA; Cowan, TM; Enns, GM; Moore, T; Vollrath, D; Yanes, RE | 1 |
| Al-Samkari, H; Kuter, DJ; Virk, ZM | 1 |
| Al, M; Armstrong, N; Buksnys, T; Büyükkaramikli, N; Drachen, T; Duffy, S; Huertas Carrera, V; Kleijnen, J; Penton, H; Raatz, H; Riemsma, R; Ryder, S; Shah, D; Swift, S; Wetzelaer, P; Worthy, G | 1 |
| Chen, W; McGee, R; Paulitz, T; Porter, L; Schroeder, K; Van Vleet, S; Vandemark, G; Wang, M | 1 |
| Gabrail, N; Smith, C | 1 |
| Lozano, ML | 1 |
| Antoine, B; Auclair, M; Capel, E; Fève, B; Roblot, N | 1 |
| Elmetwally, AM; Mohamed, AA; Mohareb, RM; Wardakhan, WW | 1 |
| Al-Samkari, H; Nagalla, S | 1 |
| Abdel-Motaal, M; Alanzy, AL; Asem, M | 1 |
| Jurczak, W; McCrae, KR; Nazir, J; Pochopien, M; Pustułka, I; Smela, B; Tytuła, A; Vredenburg, M; Wilson, K; Wojciechowski, P | 1 |
| Alwan, ES; Ibrahim, RA; Mohareb, RM | 1 |
| Buscarini, E; Dinis-Ribeiro, M; Fuccio, L; Hassan, C; Radaelli, F | 1 |
| Bussel, JB; Lee, EJ; Seshadri, M | 1 |
| Bubalo, J; Gilreath, J; Lo, M | 1 |
| Bucardo, MS; Fin, A; Li, Y; Ludford, PT; Tor, Y; Wu, Y | 1 |
| Allegra, A; Caserta, S; Innao, V; Musolino, C; Zaccuri, AM | 1 |
| Albert, R; Alcon, C; Gómez Tejeda Zañudo, J; Letai, A; Montero, J; Samitier, J; Scaltriti, M; Wagle, N | 1 |
| Balbin, A; Cresta, S; Crystal, A; Curigliano, G; De Vita, S; Duhoux, FP; He, W; Huober, J; Jhaveri, K; Ji, Y; Juric, D; Kundamal, N; Layman, RM; Sheng, Q; Takahashi, S; Terret, C; Yap, YS | 1 |
| Almalki, B; Caicedo, J; Kane, C; Maddur, H; Shroff, H | 1 |
| Markham, A | 1 |
| Abdo, NYM; Ibrahim, RA; Mohareb, RM; Samir, EM | 1 |
| Kuter, DJ | 1 |
| Chen, M; Jiang, X; Jiang, Z | 1 |
| Soussi-Yanicostas, N; Yanicostas, C | 1 |
| Maitland, HS | 1 |
| Al-Samkari, H; Jamieson, BD; Kolb-Sielecki, J; Safina, SZ; Xue, X | 1 |
| Arif, AR; Chen, W; Luo, S; Wang, Y; Xue, M; Zhao, M | 1 |
| Al-Samkari, H; Song, AB | 1 |
| Abdellattif, MH; Gomha, SM; Huwaimel, B; Riyadh, SM; Zayed, MEM | 1 |
| Chen, D; Guo, H; Liu, W; Mu, N; Wang, S; Wang, W; Yin, Y; Zhang, E | 1 |
| Cao, Z; Xiang, Y; Zhang, X; Zheng, S; Zou, Z | 1 |
86 review(s) available for thiazoles and thiophenes
| Article | Year |
|---|---|
Chemotherapy of Schistosomiasis mansoni.
Topics: Amphotericin B; Animals; Antimony; Chemosterilants; Drug Evaluation; Drug Evaluation, Preclinical; Eggs; Emetine; Humans; Hycanthone; Lucanthone; Naphthalenes; Niridazole; Nitrofurans; Organophosphorus Compounds; Oxamniquine; Schistosoma mansoni; Schistosomiasis; Schistosomicides; Snails; Thiazoles; Thiophenes; Tubercidin | 1977 |
Structure toxicity relationships--how useful are they in predicting toxicities of new drugs?
Topics: Analgesics; Androgen Antagonists; Anti-Inflammatory Agents, Non-Steroidal; Benzophenones; Bromobenzenes; Chromans; Drug-Related Side Effects and Adverse Reactions; Flutamide; Humans; Hypoglycemic Agents; Indoles; Molecular Structure; Oxindoles; Pharmaceutical Preparations; Quinolones; Structure-Activity Relationship; Thiazoles; Thiazolidinediones; Thiophenes; Troglitazone | 2001 |
Biotransformation reactions of five-membered aromatic heterocyclic rings.
Topics: Animals; Cytochrome P-450 Enzyme System; Furans; Heterocyclic Compounds, 4 or More Rings; Humans; Imidazoles; Indoles; Isoxazoles; Models, Chemical; Molecular Structure; Oxadiazoles; Oxazoles; Pyrazoles; Pyrroles; Tetrazoles; Thiadiazoles; Thiazoles; Thiophenes; Triazoles; Xenobiotics | 2002 |
GABA(A) receptor subtype selective cognition enhancers.
Topics: Alzheimer Disease; Animals; Benzodiazepines; Cognition; Cognition Disorders; Disease Models, Animal; GABA Agonists; Haplorhini; Hippocampus; Humans; Mice; Mice, Transgenic; Receptors, GABA-A; Thiazoles; Thiophenes | 2003 |
M1 muscarinic agonists can modulate some of the hallmarks in Alzheimer's disease: implications in future therapy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cell Death; Disease Models, Animal; Down-Regulation; Humans; Memory Disorders; Mice; Muscarinic Agonists; Oxidative Stress; Piperidines; Quinuclidines; Receptor, Muscarinic M1; Spiro Compounds; tau Proteins; Thiazoles; Thiophenes | 2003 |
New-generation drugs that stimulate platelet production in chronic immune thrombocytopenic purpura.
Topics: Benzoates; Carrier Proteins; Chronic Disease; Drug Approval; Hemorrhage; Humans; Hydrazines; Megakaryocytes; Methacrylates; Patient Selection; Platelet Count; Purpura, Thrombocytopenic, Idiopathic; Pyrazoles; Receptors, Fc; Receptors, Thrombopoietin; Recombinant Fusion Proteins; Safety; Thiazoles; Thiophenes; Thrombopoiesis; Thrombopoietin; Treatment Outcome; United States; United States Food and Drug Administration | 2009 |
Romiplostim: a second-generation thrombopoietin agonist.
Topics: Animals; Carrier Proteins; Humans; Purpura, Thrombocytopenic, Idiopathic; Receptors, Fc; Recombinant Fusion Proteins; Thiazoles; Thiophenes; Thrombopoiesis; Thrombopoietin | 2009 |
New anticoagulants for atrial fibrillation.
Topics: Anticoagulants; Atrial Fibrillation; Benzamides; Benzimidazoles; Biotin; Clinical Trials, Phase III as Topic; Dabigatran; Factor Xa Inhibitors; Humans; Morpholines; Oligosaccharides; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Thiazoles; Thiophenes; Vitamin K | 2009 |
Oral factor Xa inhibitors for the prevention of stroke in atrial fibrillation.
Topics: Anticoagulants; Atrial Fibrillation; Benzamides; Factor Xa Inhibitors; Fibrinolytic Agents; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Stroke; Thiazoles; Thiophenes; Thromboembolism; Warfarin | 2010 |
New antibiotics for selective treatment of gastrointestinal infection caused by Clostridium difficile.
Topics: Aminoglycosides; Anti-Bacterial Agents; Benzopyrans; Clostridioides difficile; Enterocolitis, Pseudomembranous; Fidaxomicin; Glycopeptides; Humans; Lipoglycopeptides; Nitro Compounds; Thiazoles; Thiophenes | 2010 |
[Do orally active factor Xa (FXa) inhibitors have potential as innovative new anticoagulants? Future perspective from preclinical data].
Topics: Animals; Anticoagulants; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Factor Xa Inhibitors; Humans; Intracranial Thrombosis; Macaca fascicularis; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Thiazoles; Thiophenes; Venous Thrombosis | 2010 |
Recent advances in the discovery of selective AMPA receptor positive allosteric modulators.
Topics: Allosteric Regulation; Benzamides; Drug Evaluation, Preclinical; Pyrazoles; Pyrroles; Receptors, AMPA; Sulfonamides; Thiazoles; Thiophenes | 2010 |
Allosteric enhancers of A1 adenosine receptors: state of the art and new horizons for drug development.
Topics: Allosteric Regulation; Humans; Receptor, Adenosine A1; Thiazoles; Thiophenes | 2010 |
Protein tyrosine phosphatase 1B inhibitors: a molecular level legitimate approach for the management of diabetes mellitus.
Topics: Acetophenones; Amino Acid Sequence; Animals; Benzoates; Benzofurans; Biphenyl Compounds; Blood Glucose; Catalytic Domain; Catechols; Chromones; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Fluorides; Humans; Insulin; Insulin Resistance; Insulin Secretion; Janus Kinase 2; Models, Molecular; Naphthoquinones; Peptidomimetics; Phosphates; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Pyridazines; Receptor, Insulin; Signal Transduction; STAT3 Transcription Factor; Thiazoles; Thiazolidinediones; Thiophenes; Vanadium Compounds | 2012 |
Novel oral factor Xa and thrombin inhibitors in the management of thromboembolism.
Topics: Acute Coronary Syndrome; Amidines; Anticoagulants; Atrial Fibrillation; Azetidines; Benzimidazoles; Clinical Trials as Topic; Dabigatran; Factor Xa Inhibitors; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Stroke; Thiazoles; Thiophenes; Thrombin; Thromboembolism; Treatment Outcome; Vitamin K | 2011 |
[Thromboembolic prophylaxis 2011: is warfarin on the wane?].
Topics: Administration, Oral; Anticoagulants; Atrial Fibrillation; Benzamides; Benzimidazoles; beta-Alanine; Clinical Trials, Phase III as Topic; Dabigatran; Evidence-Based Medicine; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Risk Assessment; Rivaroxaban; Thiazoles; Thiophenes; Thromboembolism; Treatment Outcome; Warfarin | 2011 |
[Current status and future of anti-Xa inhibitors].
Topics: Anticoagulants; Atrial Fibrillation; Azepines; Benzamides; Factor Xa Inhibitors; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Stroke; Thiazoles; Thiophenes | 2011 |
Long-term benefits of preventing venous thromboembolic events.
Topics: Anticoagulants; Benzimidazoles; beta-Alanine; Clinical Trials, Phase III as Topic; Dabigatran; Follow-Up Studies; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Randomized Controlled Trials as Topic; Risk Assessment; Rivaroxaban; Thiazoles; Thiophenes; Venous Thromboembolism | 2012 |
Current and future alternatives to warfarin for the prevention of stroke in atrial fibrillation.
Topics: Anticoagulants; Antithrombin Proteins; Atrial Appendage; Atrial Fibrillation; Benzimidazoles; Chemoprevention; Dabigatran; Fibrinolytic Agents; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Stroke; Thiazoles; Thiophenes; Warfarin | 2012 |
Prevention of stroke in patients with atrial fibrillation: anticoagulant and antiplatelet options.
Topics: Anticoagulants; Antithrombins; Aspirin; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Clopidogrel; Dabigatran; Hemorrhage; Humans; Morpholines; Practice Guidelines as Topic; Pyrazoles; Pyridines; Pyridones; Risk Assessment; Rivaroxaban; Stroke; Thiazoles; Thiophenes; Thrombolytic Therapy; Ticlopidine; Warfarin | 2012 |
Periprocedural antithrombotic and bridging therapy: recommendations for standardized reporting in patients with arterial indications for chronic oral anticoagulant therapy.
Topics: Administration, Oral; Anticoagulants; Benzimidazoles; beta-Alanine; Dabigatran; Elective Surgical Procedures; Factor Xa Inhibitors; Fibrinolytic Agents; Hemorrhage; Heparin, Low-Molecular-Weight; Humans; Ischemic Attack, Transient; Medical Records; Morpholines; Perioperative Period; Pyrazoles; Pyridines; Pyridones; Risk Assessment; Rivaroxaban; Stroke; Thiazoles; Thiophenes; Thromboembolism | 2012 |
The promise of novel direct oral anticoagulants.
Topics: Anticoagulants; Antithrombins; Azetidines; Benzimidazoles; Benzylamines; Clinical Trials, Phase III as Topic; Dabigatran; Factor Xa Inhibitors; Heparin, Low-Molecular-Weight; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Thiazoles; Thiophenes; Thrombin; Thromboembolism; Warfarin | 2012 |
[New oral anticoagulants - sunset for warfarin in therapy of atrial fibrillation].
Topics: Administration, Oral; Anticoagulants; Antithrombins; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Dabigatran; Electric Countershock; Factor Xa Inhibitors; Humans; Kidney Failure, Chronic; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Stroke; Thiazoles; Thiophenes; Warfarin | 2012 |
Performance of new anticoagulants for thromboprophylaxis in patients undergoing hip and knee replacement surgery.
Topics: Anticoagulants; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Benzimidazoles; beta-Alanine; Clinical Trials as Topic; Dabigatran; Evidence-Based Medicine; Humans; Morpholines; Practice Guidelines as Topic; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Societies, Medical; Thiazoles; Thiophenes; Venous Thromboembolism | 2012 |
The novel anticoagulants: the surgeons' prospective.
Topics: Anticoagulants; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Blood Loss, Surgical; Clinical Trials as Topic; Dabigatran; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Stroke; Surgical Procedures, Operative; Thiazoles; Thiophenes; Venous Thromboembolism; Warfarin | 2013 |
Anticoagulant therapy with the oral direct factor Xa inhibitors rivaroxaban, apixaban and edoxaban and the thrombin inhibitor dabigatran etexilate in patients with hepatic impairment.
Topics: Absorption; Anticoagulants; Benzimidazoles; Dabigatran; Dose-Response Relationship, Drug; Factor Xa Inhibitors; Humans; Liver Diseases; Metabolic Clearance Rate; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Thiazoles; Thiophenes; Thrombin; Tissue Distribution; Venous Thromboembolism | 2013 |
[New approaches in the treatment of deep vein thrombosis].
Topics: Administration, Oral; Anticoagulants; Benzimidazoles; beta-Alanine; Biotin; Clinical Trials, Phase III as Topic; Dabigatran; Drug Administration Schedule; Humans; Morpholines; Oligosaccharides; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Thiazoles; Thiophenes; Venous Thrombosis | 2012 |
[Improvements in oral anticoagulant therapy for atrial fibrillation].
Topics: Administration, Oral; Anticoagulants; Atrial Fibrillation; Azetidines; Benzimidazoles; Benzylamines; beta-Alanine; Dabigatran; Embolism; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Stroke; Thiazoles; Thiophenes; Treatment Outcome; Warfarin | 2013 |
Use of new oral anticoagulants in antiphospholipid syndrome.
Topics: Administration, Oral; Adult; Animals; Anticoagulants; Antiphospholipid Syndrome; Benzimidazoles; beta-Alanine; Breast Feeding; Clinical Trials, Phase III as Topic; Contraindications; Dabigatran; Drug Monitoring; Female; Humans; Infant, Newborn; Maternal Exposure; Morpholines; Pregnancy; Pyrazoles; Pyridines; Pyridones; Randomized Controlled Trials as Topic; Rivaroxaban; Thiazoles; Thiophenes | 2013 |
Venous thromboembolism management: where do novel anticoagulants fit?
Topics: Anticoagulants; Benzimidazoles; beta-Alanine; Dabigatran; Factor X; Heparin; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Thiazoles; Thiophenes; Thrombin; Venous Thromboembolism; Vitamin K; Warfarin | 2013 |
Laboratory monitoring of anticoagulant medications: focus on novel oral anticoagulants.
Topics: Anticoagulants; Antithrombins; Benzimidazoles; beta-Alanine; Blood Coagulation Tests; Dabigatran; Drug Monitoring; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Thiazoles; Thiophenes; Thrombosis | 2013 |
Alternatives to warfarin for stroke prevention in patients with nonvalvular atrial fibrillation: a look back at the state of the field in 2012.
Topics: Anticoagulants; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Dabigatran; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Stroke; Thiazoles; Thiophenes; Warfarin | 2013 |
New oral anticoagulants for the treatment of venous thromboembolism.
Topics: Administration, Oral; Adult; Aged; Anticoagulants; Benzimidazoles; beta-Alanine; Dabigatran; Drug Administration Schedule; Humans; Middle Aged; Morpholines; Pulmonary Embolism; Pyrazoles; Pyridines; Pyridones; Randomized Controlled Trials as Topic; Rivaroxaban; Thiazoles; Thiophenes; Venous Thromboembolism; Warfarin | 2013 |
Bleeding and antidotes in new oral anticoagulants.
Topics: Administration, Oral; Anticoagulants; Benzimidazoles; beta-Alanine; Blood Coagulation Factors; Dabigatran; Drug Administration Schedule; Hemorrhage; Hemostatics; Humans; Morpholines; Prothrombin; Pyrazoles; Pyridines; Pyridones; Randomized Controlled Trials as Topic; Rivaroxaban; Thiazoles; Thiophenes; Thromboembolism | 2013 |
Advantages and limitations of the new anticoagulants.
Topics: Administration, Oral; Anticoagulants; Benzimidazoles; beta-Alanine; Blood Coagulation; Dabigatran; Disease Management; Dose-Response Relationship, Drug; Drug Interactions; Drug Monitoring; Factor Xa Inhibitors; Humans; Intracranial Hemorrhages; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Thiazoles; Thiophenes; Thromboembolism | 2014 |
Effectiveness and safety of novel oral anticoagulants as compared with vitamin K antagonists in the treatment of acute symptomatic venous thromboembolism: a systematic review and meta-analysis.
Topics: Administration, Oral; Anticoagulants; Benzimidazoles; beta-Alanine; Dabigatran; Female; Hemorrhage; Humans; Male; Morpholines; Pyrazoles; Pyridines; Pyridones; Randomized Controlled Trials as Topic; Risk Factors; Rivaroxaban; Thiazoles; Thiophenes; Treatment Outcome; Venous Thromboembolism; Vitamin K | 2014 |
New oral anticoagulant agents - general features and outcomes in subsets of patients.
Topics: Administration, Oral; Anticoagulants; Benzimidazoles; beta-Alanine; Clinical Trials, Phase III as Topic; Dabigatran; Hemorrhage; Humans; Morpholines; Patient Selection; Pyrazoles; Pyridines; Pyridones; Risk; Rivaroxaban; Stroke; Thiazoles; Thiophenes; Treatment Outcome; Venous Thromboembolism; Warfarin | 2014 |
Current state of anticoagulants to treat deep venous thrombosis.
Topics: Anticoagulants; Benzimidazoles; beta-Alanine; Dabigatran; Humans; Medication Adherence; Morpholines; Patient Selection; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Thiazoles; Thiophenes; Venous Thrombosis | 2014 |
Direct oral anticoagulants in the treatment and long-term prevention of venous thrombo-embolism.
Topics: Acute Disease; Administration, Oral; Antithrombins; Benzimidazoles; beta-Alanine; Clinical Trials, Phase III as Topic; Dabigatran; Hemorrhage; Humans; Long-Term Care; Morpholines; Perioperative Care; Pulmonary Embolism; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Thiazoles; Thiophenes; Treatment Outcome; Venous Thromboembolism; Vitamin K | 2014 |
New oral anticoagulants for stroke prevention in atrial fibrillation: impact of study design, double counting and unexpected findings on interpretation of study results and conclusions.
Topics: Administration, Oral; Anticoagulants; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Clinical Trials as Topic; Dabigatran; Data Interpretation, Statistical; Humans; Morpholines; Practice Guidelines as Topic; Pyrazoles; Pyridines; Pyridones; Research Design; Rivaroxaban; Stroke; Thiazoles; Thiophenes; Treatment Outcome | 2014 |
[Pharmacologic and clinical characteristics of direct inhibitors of factor Xa: rivaroxaban, apixaban, edoxaban and betrixaban].
Topics: Acute Coronary Syndrome; Administration, Oral; Anticoagulants; Benzamides; Blood Coagulation; Embolism; Factor Xa Inhibitors; Hemorrhage; Hemostatics; Humans; Morpholines; Postoperative Complications; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Stroke; Thiazoles; Thiophenes; Thrombophilia; Thrombosis | 2014 |
Direct oral anticoagulants in the prevention of venous thromboembolism: evidence from major clinical trials.
Topics: Administration, Oral; Anticoagulants; Benzimidazoles; beta-Alanine; Clinical Trials as Topic; Dabigatran; Half-Life; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Thiazoles; Thiophenes; Venous Thromboembolism; Vitamin K | 2014 |
Direct oral anticoagulants in the management of venous thromboembolism--evidence from major clinical trials.
Topics: Administration, Oral; Anticoagulants; Benzimidazoles; beta-Alanine; Clinical Trials as Topic; Dabigatran; Humans; Morpholines; Neoplasms; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Thiazoles; Thiophenes; Venous Thromboembolism | 2014 |
Stroke prevention in atrial fibrillation: established oral anticoagulants versus novel anticoagulants-translating clinical trial data into practice.
Topics: Administration, Oral; Anticoagulants; Antithrombins; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Dabigatran; Factor Xa Inhibitors; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Stroke; Thiazoles; Thiophenes; Translational Research, Biomedical; Treatment Outcome | 2014 |
Evolving use of new oral anticoagulants for treatment of venous thromboembolism.
Topics: Administration, Oral; Anticoagulants; Benzimidazoles; beta-Alanine; Dabigatran; Drug Therapy; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Thiazoles; Thiophenes; Treatment Outcome; Venous Thromboembolism | 2014 |
Editor's Choice - efficacy and safety of the new oral anticoagulants dabigatran, rivaroxaban, apixaban, and edoxaban in the treatment and secondary prevention of venous thromboembolism: a systematic review and meta-analysis of phase III trials.
Topics: Administration, Oral; Anticoagulants; Benzimidazoles; beta-Alanine; Clinical Trials, Phase III as Topic; Dabigatran; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Secondary Prevention; Thiazoles; Thiophenes; Venous Thromboembolism | 2014 |
Direct oral anticoagulants compared with vitamin K antagonists for acute venous thromboembolism: evidence from phase 3 trials.
Topics: Acute Disease; Administration, Oral; Anticoagulants; Benzimidazoles; Clinical Trials, Phase III as Topic; Dabigatran; Factor Xa Inhibitors; Female; Hemorrhage; Humans; Male; Morpholines; Pyrazoles; Pyridines; Pyridones; Randomized Controlled Trials as Topic; Rivaroxaban; Thiazoles; Thiophenes; Venous Thromboembolism; Vitamin K | 2014 |
Direct oral anticoagulants in the treatment of acute venous thromboembolism: a systematic review and meta-analysis.
Topics: Administration, Oral; Animals; Anticoagulants; Benzimidazoles; beta-Alanine; Dabigatran; Hemorrhage; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Thiazoles; Thiophenes; Venous Thromboembolism | 2014 |
Atrial fibrillation - new frontiers in anticoagulation.
Topics: Administration, Oral; Animals; Anticoagulants; Atrial Fibrillation; Benzimidazoles; Dabigatran; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Stroke; Thiazoles; Thiophenes | 2014 |
Novel anticoagulants vs warfarin for stroke prevention in atrial fibrillation.
Topics: Animals; Anticoagulants; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Dabigatran; Drug Discovery; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Stroke; Thiazoles; Thiophenes; Warfarin | 2014 |
Pharmacology and laboratory testing of the oral Xa inhibitors.
Topics: Administration, Oral; Benzamides; Blood Coagulation Tests; Drug Monitoring; Factor Xa Inhibitors; Hemorrhage; Humans; Morpholines; Precision Medicine; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Thiazoles; Thiophenes | 2014 |
Oral anticoagulants for stroke prevention in atrial fibrillation.
Topics: Administration, Oral; Anticoagulants; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Dabigatran; Drug Administration Schedule; Drug Therapy, Combination; Humans; Morpholines; Patient Preference; Platelet Aggregation Inhibitors; Pyrazoles; Pyridines; Pyridones; Randomized Controlled Trials as Topic; Research Design; Rivaroxaban; Stroke; Thiazoles; Thiophenes | 2014 |
Target-specific oral anticoagulants: practice issues for the clinician.
Topics: Administration, Oral; Anticoagulants; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Dabigatran; Drug Interactions; Humans; Medication Adherence; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Stroke; Thiazoles; Thiophenes; Venous Thromboembolism; Warfarin | 2014 |
Switching between oral anticoagulants.
Topics: Administration, Oral; Anticoagulants; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Dabigatran; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Stroke; Thiazoles; Thiophenes; United States; Warfarin | 2014 |
Testing the therapeutic equivalence of novel oral anticoagulants for thromboprophylaxis in orthopedic surgery and for prevention of stroke in atrial fibrillation.
Topics: Administration, Oral; Anticoagulants; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Blood Coagulation; Dabigatran; Humans; Morpholines; Orthopedic Procedures; Patient Safety; Pyrazoles; Pyridines; Pyridones; Risk Assessment; Rivaroxaban; Stroke; Therapeutic Equivalency; Thiazoles; Thiophenes; Treatment Outcome; Venous Thromboembolism | 2015 |
New oral anticoagulants for the treatment of venous thromboembolism: understanding differences and similarities.
Topics: Administration, Oral; Anticoagulants; Benzimidazoles; Dabigatran; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Thiazoles; Thiophenes; Venous Thromboembolism | 2014 |
Balancing ischaemia and bleeding risks with novel oral anticoagulants.
Topics: Antithrombins; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Dabigatran; Factor Xa Inhibitors; Hemorrhage; Humans; Ischemia; Morpholines; Pyrazoles; Pyridines; Pyridones; Risk Assessment; Rivaroxaban; Stroke; Thiazoles; Thiophenes; Venous Thromboembolism | 2014 |
Risk of major bleeding in different indications for new oral anticoagulants: insights from a meta-analysis of approved dosages from 50 randomized trials.
Topics: Administration, Oral; Antithrombins; Azepines; Benzamides; Benzimidazoles; beta-Alanine; Dabigatran; Factor Xa Inhibitors; Hemorrhage; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Randomized Controlled Trials as Topic; Risk; Rivaroxaban; Thiazoles; Thiophenes | 2015 |
Strategies for urgent reversal of target-specific oral anticoagulants.
Topics: Administration, Oral; Anticoagulants; Benzimidazoles; beta-Alanine; Blood Coagulation Factors; Charcoal; Dabigatran; Factor VIIa; Hemorrhage; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Recombinant Proteins; Renal Dialysis; Rivaroxaban; Thiazoles; Thiophenes | 2014 |
Treatment of echinococcosis: albendazole and mebendazole--what else?
Topics: Albendazole; Animals; Anthelmintics; Cell Division; Clarithromycin; Cytostatic Agents; Drug Design; Drug Evaluation, Preclinical; Echinococcosis; Echinococcosis, Hepatic; Echinococcus multilocularis; Forecasting; Guanidines; Helminth Proteins; Host-Parasite Interactions; Humans; Imidazoles; Larva; Mebendazole; Mefloquine; Mice; Molecular Targeted Therapy; Nitro Compounds; Thiazoles; Thiophenes | 2014 |
Pharmacotherapy with oral Xa inhibitors for venous thromboembolism.
Topics: Administration, Oral; Clinical Trials, Phase III as Topic; Factor Xa; Factor Xa Inhibitors; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Thiazoles; Thiophenes; Venous Thromboembolism | 2015 |
Non-vitamin K antagonist oral anticoagulants (NOACs): a view from the laboratory.
Topics: Administration, Oral; Anticoagulants; Benzimidazoles; beta-Alanine; Dabigatran; Dose-Response Relationship, Drug; Hemorrhage; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Thiazoles; Thiophenes; Thrombosis; Treatment Outcome; Vitamin K | 2014 |
Changing practice of anticoagulation: will target-specific anticoagulants replace warfarin?
Topics: Anticoagulants; Antithrombins; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Dabigatran; Factor Xa Inhibitors; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Stroke; Thiazoles; Thiophenes; Venous Thromboembolism; Warfarin | 2015 |
The role of factor Xa inhibitors in venous thromboembolism treatment.
Topics: Animals; Blood Coagulation; Factor Xa Inhibitors; Hemorrhage; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Risk Factors; Rivaroxaban; Thiazoles; Thiophenes; Treatment Outcome; Venous Thromboembolism | 2015 |
Overview of the new oral anticoagulants: opportunities and challenges.
Topics: Administration, Oral; Anticoagulants; Antithrombins; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Dabigatran; Dose-Response Relationship, Drug; Drug Administration Schedule; Factor Xa Inhibitors; Female; Humans; Male; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Sensitivity and Specificity; Stroke; Thiazoles; Thiophenes; Thromboembolism; Warfarin | 2015 |
Exercise Pills: At the Starting Line.
Topics: Acetylcarnitine; Animals; Biomimetic Materials; Catechin; Exercise; Fibronectins; Humans; Molecular Targeted Therapy; Pyrrolidines; Resveratrol; Stilbenes; Thiazoles; Thiophenes | 2015 |
Management of Thrombocytopenia in Chronic Liver Disease: Focus on Pharmacotherapeutic Strategies.
Topics: Benzoates; Chronic Disease; Disease Management; Hepatitis C, Chronic; Humans; Hydrazines; Liver Diseases; Pyrazoles; Receptors, Fc; Receptors, Thrombopoietin; Recombinant Fusion Proteins; Thiazoles; Thiophenes; Thrombocytopenia; Thrombopoietin | 2015 |
Advances in development of fluorescent probes for detecting amyloid-β aggregates.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Boron Compounds; Curcumin; Fluorescent Dyes; Humans; Optical Imaging; Stilbenes; Thiazoles; Thiophenes | 2016 |
Polymerase Acidic Protein-Basic Protein 1 (PA-PB1) Protein-Protein Interaction as a Target for Next-Generation Anti-influenza Therapeutics.
Topics: Animals; Antiviral Agents; Benzofurans; Drug Resistance, Viral; Humans; Multiprotein Complexes; Orthomyxoviridae; Peptides; Pyrazoles; Pyridines; Pyrimidines; RNA-Dependent RNA Polymerase; Structure-Activity Relationship; Thiazoles; Thiophenes; Viral Proteins | 2016 |
Novel antibiotics in development to treat Clostridium difficile infection.
Topics: Anti-Bacterial Agents; Benzimidazoles; Benzopyrans; Clinical Trials as Topic; Clostridium Infections; Depsipeptides; Humans; Lipopeptides; Oxazolidinones; Peptides, Cyclic; Pyridines; Thiazoles; Thiophenes | 2017 |
Avatrombopag: First Global Approval.
Topics: Chronic Disease; Drug Approval; Humans; Liver Diseases; Receptors, Thrombopoietin; Thiazoles; Thiophenes; Thrombocytopenia; United States; United States Food and Drug Administration | 2018 |
Avatrombopag maleate for the treatment of periprocedural thrombocytopenia in patients with chronic liver disease.
Topics: Animals; Chronic Disease; Drug Interactions; Hematologic Agents; Humans; Liver Diseases; Perioperative Period; Thiazoles; Thiophenes; Thrombocytopenia; Treatment Outcome | 2018 |
Avatrombopag for the treatment of immune thrombocytopenia.
Topics: Animals; Blood Platelets; Clinical Trials as Topic; Humans; Platelet Count; Purpura, Thrombocytopenic, Idiopathic; Receptors, Thrombopoietin; Thiazoles; Thiophenes; United States; United States Food and Drug Administration | 2019 |
New Small Molecule Drugs for Thrombocytopenia: Chemical, Pharmacological, and Therapeutic Use Considerations.
Topics: Aminopyridines; Animals; Cinnamates; Drug Development; Humans; Morpholines; Oxazines; Pyridines; Pyrimidines; Receptors, Thrombopoietin; Small Molecule Libraries; Syk Kinase; Thiazoles; Thiophenes; Thrombocytopenia | 2019 |
Dose-Response Meta-Analysis of Antipsychotic Drugs for Acute Schizophrenia.
Topics: Acute Disease; Administration, Oral; Antipsychotic Agents; Aripiprazole; Clozapine; Delayed-Action Preparations; Dose-Response Relationship, Drug; Haloperidol; Humans; Imidazoles; Indoles; Isoxazoles; Lurasidone Hydrochloride; Olanzapine; Paliperidone Palmitate; Piperazines; Piperidines; Quetiapine Fumarate; Quinolones; Risperidone; Schizophrenia; Schizophrenic Psychology; Thiazoles; Thiophenes | 2020 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor Proteins, Signal Transducing; Adenine; Adenocarcinoma; Adipogenesis; Administration, Cutaneous; Administration, Ophthalmic; Adolescent; Adsorption; Adult; Aeromonas hydrophila; Aerosols; Aged; Aged, 80 and over; Aging; Agriculture; Air Pollutants; Air Pollution; Airway Remodeling; Alanine Transaminase; Albuminuria; Aldehyde Dehydrogenase 1 Family; Algorithms; AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase; Alzheimer Disease; Amino Acid Sequence; Ammonia; Ammonium Compounds; Anaerobiosis; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Antibodies, Antineutrophil Cytoplasmic; Antibodies, Monoclonal, Humanized; Antifungal Agents; Antigens, Bacterial; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antitubercular Agents; Antiviral Agents; Apolipoproteins E; Apoptosis; Arabidopsis; Arabidopsis Proteins; Arsenic; Arthritis, Rheumatoid; Asthma; Atherosclerosis; ATP-Dependent Proteases; Attitude of Health Personnel; Australia; Austria; Autophagy; Axitinib; Bacteria; Bacterial Outer Membrane Proteins; Bacterial Proteins; Bacterial Toxins; Bacterial Typing Techniques; Bariatric Surgery; Base Composition; Bayes Theorem; Benzoxazoles; Benzylamines; beta Catenin; Betacoronavirus; Betula; Binding Sites; Biological Availability; Biological Oxygen Demand Analysis; Biomarkers; Biomarkers, Tumor; Biopsy; Bioreactors; Biosensing Techniques; Birth Weight; Blindness; Blood Chemical Analysis; Blood Gas Analysis; Blood Glucose; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Blood-Brain Barrier; Blotting, Western; Body Mass Index; Body Weight; Bone and Bones; Bone Density; Bone Resorption; Borates; Brain; Brain Infarction; Brain Injuries, Traumatic; Brain Neoplasms; Breakfast; Breast Milk Expression; Breast Neoplasms; Bronchi; Bronchoalveolar Lavage Fluid; Buffaloes; Cadherins; Calcification, Physiologic; Calcium Compounds; Calcium, Dietary; Cannula; Caprolactam; Carbon; Carbon Dioxide; Carboplatin; Carcinogenesis; Carcinoma, Ductal; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Cardiovascular Diseases; Carps; Carrageenan; Case-Control Studies; Catalysis; Catalytic Domain; Cattle; CD8-Positive T-Lymphocytes; Cell Adhesion; Cell Cycle Proteins; Cell Death; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Phone Use; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Cellulose; Chemical Phenomena; Chemoradiotherapy; Child; Child Development; Child, Preschool; China; Chitosan; Chlorocebus aethiops; Cholecalciferol; Chromatography, Liquid; Circadian Clocks; Circadian Rhythm; Circular Dichroism; Cisplatin; Citric Acid; Clinical Competence; Clinical Laboratory Techniques; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clostridioides difficile; Clostridium Infections; Coculture Techniques; Cohort Studies; Cold Temperature; Colitis; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type XI; Color; Connective Tissue Diseases; Copper; Coronary Angiography; Coronavirus 3C Proteases; Coronavirus Infections; Cost of Illness; Counselors; COVID-19; COVID-19 Testing; Creatine Kinase; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Cryoelectron Microscopy; Cryosurgery; Crystallography, X-Ray; Cues; Cultural Competency; Cultural Diversity; Curriculum; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase Inhibitor p21; Cycloparaffins; Cysteine Endopeptidases; Cytokines; Cytoplasm; Cytoprotection; Databases, Factual; Denitrification; Deoxycytidine; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diagnosis, Differential; Diatoms; Diet; Diet, High-Fat; Dietary Exposure; Diffusion Magnetic Resonance Imaging; Diketopiperazines; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Disease Progression; Disease-Free Survival; DNA; DNA Damage; DNA Glycosylases; DNA Repair; DNA-Binding Proteins; DNA, Bacterial; DNA, Viral; Docetaxel; Dose Fractionation, Radiation; Dose-Response Relationship, Drug; Down-Regulation; Doxorubicin; Drosophila; Drosophila melanogaster; Drug Carriers; Drug Delivery Systems; Drug Liberation; Drug Repositioning; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Drug Therapy, Combination; Edema; Edible Grain; Education, Graduate; Education, Medical, Graduate; Education, Pharmacy; Ehlers-Danlos Syndrome; Electron Transport Complex III; Electron Transport Complex IV; Electronic Nicotine Delivery Systems; Emergency Service, Hospital; Empathy; Emulsions; Endothelial Cells; Endurance Training; Energy Intake; Enterovirus A, Human; Environment; Environmental Monitoring; Enzyme Assays; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Epoxide Hydrolases; Epoxy Compounds; Erythrocyte Count; Erythrocytes; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Esophagectomy; Estrogens; Etanercept; Ethiopia; Ethnicity; Ethylenes; Exanthema; Exercise; Exercise Test; Exercise Tolerance; Extracellular Matrix; Extracorporeal Membrane Oxygenation; Eye Infections, Fungal; False Negative Reactions; Fatty Acids; Fecal Microbiota Transplantation; Feces; Female; Femur Neck; Fermentation; Ferritins; Fetal Development; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Fibroblasts; Fibroins; Fish Proteins; Flavanones; Flavonoids; Focus Groups; Follow-Up Studies; Food Handling; Food Supply; Food, Formulated; Forced Expiratory Volume; Forests; Fractures, Bone; Fruit and Vegetable Juices; Fusobacteria; G1 Phase Cell Cycle Checkpoints; G2 Phase Cell Cycle Checkpoints; Gamma Rays; Gastrectomy; Gastrointestinal Microbiome; Gastrointestinal Stromal Tumors; Gefitinib; Gels; Gemcitabine; Gene Amplification; Gene Expression; Gene Expression Regulation; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Plant; Gene Knockdown Techniques; Gene-Environment Interaction; Genotype; Germany; Glioma; Glomerular Filtration Rate; Glucagon; Glucocorticoids; Glycemic Control; Glycerol; Glycogen Synthase Kinase 3 beta; Glycolipids; Glycolysis; Goblet Cells; Gram-Negative Bacterial Infections; Granulocyte Colony-Stimulating Factor; Graphite; Greenhouse Effect; Guanidines; Haemophilus influenzae; HCT116 Cells; Health Knowledge, Attitudes, Practice; Health Personnel; Health Services Accessibility; Health Services Needs and Demand; Health Status Disparities; Healthy Volunteers; Heart Failure; Heart Rate; Heart Transplantation; Heart-Assist Devices; HEK293 Cells; Heme; Heme Oxygenase-1; Hemolysis; Hemorrhage; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hepatocytes; Hexoses; High-Throughput Nucleotide Sequencing; Hippo Signaling Pathway; Histamine; Histamine Agonists; Histidine; Histone Deacetylase 2; HIV Infections; HIV Reverse Transcriptase; HIV-1; Homebound Persons; Homeodomain Proteins; Homosexuality, Male; Hospice and Palliative Care Nursing; HSP70 Heat-Shock Proteins; Humans; Hyaluronan Receptors; Hydrogen; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrolysis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemia; Hypoglycemic Agents; Hypoxia; Idiopathic Interstitial Pneumonias; Imaging, Three-Dimensional; Imatinib Mesylate; Immunotherapy; Implementation Science; Incidence; INDEL Mutation; Induced Pluripotent Stem Cells; Industrial Waste; Infant; Infant, Newborn; Inflammation; Inflammation Mediators; Infliximab; Infusions, Intravenous; Inhibitory Concentration 50; Injections; Insecticides; Insulin-Like Growth Factor Binding Protein 5; Insulin-Secreting Cells; Interleukin-1; Interleukin-17; Interleukin-8; Internship and Residency; Intestines; Intracellular Signaling Peptides and Proteins; Ion Transport; Iridaceae; Iridoid Glucosides; Islets of Langerhans Transplantation; Isodon; Isoflurane; Isotopes; Italy; Joint Instability; Ketamine; Kidney; Kidney Failure, Chronic; Kidney Function Tests; Kidney Neoplasms; Kinetics; Klebsiella pneumoniae; Knee Joint; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Lactate Dehydrogenase 5; Laparoscopy; Laser Therapy; Lasers, Semiconductor; Lasers, Solid-State; Laurates; Lead; Leukocyte L1 Antigen Complex; Leukocytes, Mononuclear; Light; Lipid Peroxidation; Lipopolysaccharides; Liposomes; Liver; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Locomotion; Longitudinal Studies; Lopinavir; Lower Urinary Tract Symptoms; Lubricants; Lung; Lung Diseases, Interstitial; Lung Neoplasms; Lymphocyte Activation; Lymphocytes, Tumor-Infiltrating; Lymphoma, Mantle-Cell; Lysosomes; Macrophages; Male; Manganese Compounds; MAP Kinase Kinase 4; Mass Screening; Maternal Health; Medicine, Chinese Traditional; Melanoma, Experimental; Memantine; Membrane Glycoproteins; Membrane Proteins; Mesenchymal Stem Cell Transplantation; Metal Nanoparticles; Metalloendopeptidases; Metalloporphyrins; Methadone; Methane; Methicillin-Resistant Staphylococcus aureus; Mexico; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Mice, Nude; Mice, SCID; Mice, Transgenic; Microarray Analysis; Microbial Sensitivity Tests; Microbiota; Micronutrients; MicroRNAs; Microscopy, Confocal; Microsomes, Liver; Middle Aged; Milk; Milk, Human; Minority Groups; Mitochondria; Mitochondrial Membranes; Mitochondrial Proteins; Models, Animal; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Epidemiology; 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Oocytes; Open Reading Frames; Osteoclasts; Osteogenesis; Osteoporosis; Osteoporosis, Postmenopausal; Outpatients; Ovarian Neoplasms; Ovariectomy; Overweight; Oxazines; Oxidants; Oxidation-Reduction; Oxidative Stress; Oxides; Oxidoreductases; Oxygen; Oxygen Inhalation Therapy; Oxygenators, Membrane; Ozone; Paclitaxel; Paenibacillus; Pain Measurement; Palliative Care; Pancreatic Neoplasms; Pandemics; Parasympathetic Nervous System; Particulate Matter; Pasteurization; Patient Preference; Patient Satisfaction; Pediatric Obesity; Permeability; Peroxiredoxins; Peroxynitrous Acid; Pharmaceutical Services; Pharmacists; Pharmacy; Phaseolus; Phenotype; Phoeniceae; Phosphates; Phosphatidylinositol 3-Kinases; Phospholipid Transfer Proteins; Phospholipids; Phosphorus; Phosphorylation; Photoperiod; Photosynthesis; Phylogeny; Physical Endurance; Physicians; Pilot Projects; Piperidines; Pituitary Adenylate Cyclase-Activating Polypeptide; Plant Extracts; Plant Leaves; Plant Proteins; Plant Roots; Plaque, Atherosclerotic; Pneumonia; Pneumonia, Viral; Point-of-Care Testing; Polyethylene Glycols; Polymers; Polysorbates; Pore Forming Cytotoxic Proteins; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Postprandial Period; Poverty; Pre-Exposure Prophylaxis; Prediabetic State; Predictive Value of Tests; Pregnancy; Pregnancy Trimester, First; Pregnancy, High-Risk; Prenatal Exposure Delayed Effects; Pressure; Prevalence; Primary Graft Dysfunction; Primary Health Care; Professional Role; Professionalism; Prognosis; Progression-Free Survival; Prolactin; Promoter Regions, Genetic; Proof of Concept Study; Proportional Hazards Models; Propylene Glycol; Prospective Studies; Prostate; Protein Binding; Protein Biosynthesis; Protein Isoforms; Protein Kinase Inhibitors; Protein Phosphatase 2; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein Transport; Proteoglycans; Proteome; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins c-ret; Proto-Oncogene Proteins p21(ras); Proton Pumps; Protons; Protoporphyrins; Pseudomonas aeruginosa; Pseudomonas fluorescens; Pulmonary Artery; Pulmonary Disease, Chronic Obstructive; Pulmonary Gas Exchange; Pulmonary Veins; Pyrazoles; Pyridines; Pyrimidines; Qualitative Research; Quinoxalines; Rabbits; Random Allocation; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Histamine H3; Receptors, Immunologic; Receptors, Transferrin; Recombinant Proteins; Recurrence; Reference Values; Referral and Consultation; Regional Blood Flow; Registries; Regulon; Renal Insufficiency, Chronic; Reperfusion Injury; Repressor Proteins; Reproducibility of Results; Republic of Korea; Research Design; Resistance Training; Respiration, Artificial; Respiratory Distress Syndrome; Respiratory Insufficiency; Resuscitation; Retinal Dehydrogenase; Retreatment; Retrospective Studies; Reverse Transcriptase Inhibitors; Rhinitis, Allergic; Ribosomal Proteins; Ribosomes; Risk Assessment; Risk Factors; Ritonavir; Rivers; RNA Interference; RNA-Seq; RNA, Messenger; RNA, Ribosomal, 16S; RNA, Small Interfering; Rosuvastatin Calcium; Rural Population; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salivary Ducts; Salivary Gland Neoplasms; San Francisco; SARS-CoV-2; Satiation; Satiety Response; Schools; Schools, Pharmacy; Seasons; Seawater; Selection, Genetic; Sequence Analysis, DNA; Serine-Threonine Kinase 3; Sewage; Sheep; Sheep, Domestic; Shock, Hemorrhagic; Signal Transduction; Silver; Silymarin; Single Photon Emission Computed Tomography Computed Tomography; Sirolimus; Sirtuin 1; Skin; Skin Neoplasms; Skin Physiological Phenomena; Sleep Initiation and Maintenance Disorders; Social Class; Social Participation; Social Support; Soil; Soil Microbiology; Solutions; Somatomedins; Soot; Specimen Handling; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis; Spinal Fractures; Spirometry; Staphylococcus aureus; STAT1 Transcription Factor; STAT3 Transcription Factor; Streptomyces coelicolor; Stress, Psychological; Stroke; Stroke Volume; Structure-Activity Relationship; Students, Medical; Students, Pharmacy; Substance Abuse Treatment Centers; Sulfur Dioxide; Surface Properties; Surface-Active Agents; Surveys and Questionnaires; Survival Analysis; Survival Rate; Survivin; Sweden; Swine; Swine, Miniature; Sympathetic Nervous System; T-Lymphocytes, Regulatory; Talaromyces; Tandem Mass Spectrometry; tau Proteins; Telemedicine; Telomerase; Telomere; Telomere Homeostasis; Temperature; Terminally Ill; Th1 Cells; Thiamethoxam; Thiazoles; Thiophenes; Thioredoxin Reductase 1; Thrombosis; Thulium; Thyroid Cancer, Papillary; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Time Factors; Titanium; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transcriptome; Transforming Growth Factor beta1; Transistors, Electronic; Translational Research, Biomedical; Transplantation Tolerance; Transplantation, Homologous; Transportation; Treatment Outcome; Tretinoin; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary; Tubulin Modulators; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Twins; Ultrasonic Therapy; Ultrasonography; Ultraviolet Rays; United States; Up-Regulation; Uranium; Urethra; Urinary Bladder; Urodynamics; Uromodulin; Uveitis; Vasoconstrictor Agents; Ventricular Function, Left; Vero Cells; Vesicular Transport Proteins; Viral Nonstructural Proteins; Visual Acuity; Vital Capacity; Vitamin D; Vitamin D Deficiency; Vitamin K 2; Vitamins; Volatilization; Voriconazole; Waiting Lists; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical; Whole Genome Sequencing; Wine; Wnt Signaling Pathway; Wound Healing; Wounds and Injuries; WW Domains; X-linked Nuclear Protein; X-Ray Diffraction; Xanthines; Xenograft Model Antitumor Assays; YAP-Signaling Proteins; Yogurt; Young Adult; Zebrafish; Zebrafish Proteins; Ziziphus | 2016 |
Thrombocytopenia in Chronic Liver Disease: New Management Strategies.
Topics: Chronic Disease; Cinnamates; Hemorrhage; Humans; Liver Diseases; Platelet Count; Platelet Transfusion; Receptors, Thrombopoietin; Risk Factors; Surgical Procedures, Operative; Thiazoles; Thiophenes; Thrombocytopenia; Thrombopoiesis | 2020 |
Avatrombopag and lusutrombopag for thrombocytopenia in people with chronic liver disease needing an elective procedure: a systematic review and cost-effectiveness analysis.
Topics: Bayes Theorem; Cinnamates; Clinical Trials as Topic; Cost-Benefit Analysis; End Stage Liver Disease; Humans; Models, Economic; Platelet Transfusion; Quality-Adjusted Life Years; Receptors, Thrombopoietin; Secondary Care; Technology Assessment, Biomedical; Thiazoles; Thiophenes; Thrombocytopenia | 2020 |
Avatrombopag for the management of thrombocytopenia in patients with chronic liver disease.
Topics: Adult; Chronic Disease; Humans; Liver Diseases; Thiazoles; Thiophenes; Thrombocytopenia | 2021 |
Efficacy and Safety of Avatrombopag in Patients with Chronic Immune Thrombocytopenia: A Systematic Literature Review and Network Meta-Analysis.
Topics: Benzoates; Humans; Network Meta-Analysis; Purpura, Thrombocytopenic, Idiopathic; Randomized Controlled Trials as Topic; Recombinant Fusion Proteins; Thiazoles; Thiophenes | 2021 |
Thrombopoietin Receptor Agonists (TPO-RAs): Drug Class Considerations for Pharmacists.
Topics: Benzoates; Cinnamates; Dose-Response Relationship, Drug; Drug Monitoring; Health Knowledge, Attitudes, Practice; Humans; Hydrazines; Pharmacists; Platelet Count; Pyrazoles; Receptors, Fc; Receptors, Thrombopoietin; Recombinant Fusion Proteins; Thiazoles; Thiophenes; Thrombocytopenia; Thrombopoietin | 2021 |
Immune thrombocytopenia: options and new perspectives.
Topics: Aminopyridines; Antibodies, Monoclonal, Humanized; COVID-19; Histocompatibility Antigens Class I; Humans; Immunosuppressive Agents; Morpholines; Protein Kinase Inhibitors; Purpura, Thrombocytopenic, Idiopathic; Pyrimidines; Receptors, Fc; Receptors, Thrombopoietin; SARS-CoV-2; Syk Kinase; Thiazoles; Thiophenes | 2021 |
Avatrombopag: A Review in Thrombocytopenia.
Topics: Adult; Animals; Chronic Disease; Humans; Liver Diseases; Purpura, Thrombocytopenic, Idiopathic; Receptors, Thrombopoietin; Thiazoles; Thiophenes; Thrombocytopenia | 2021 |
The structure, function, and clinical use of the thrombopoietin receptor agonist avatrombopag.
Topics: Anemia, Aplastic; Hepatitis C; Humans; Liver Diseases; Receptors, Thrombopoietin; Thiazoles; Thiophenes; Thrombopoietin | 2022 |
SDHI Fungicide Toxicity and Associated Adverse Outcome Pathways: What Can Zebrafish Tell Us?
Topics: Abnormalities, Multiple; Amides; Anilides; Animals; Biphenyl Compounds; Embryo, Nonmammalian; Energy Metabolism; Enzyme Inhibitors; Fish Proteins; Fungicides, Industrial; Gene Expression; Niacinamide; Norbornanes; Pyrazoles; Succinate Dehydrogenase; Thiazoles; Thiophenes; Zebrafish | 2021 |
Mutasynthesis Generates Antibacterial Benzothiophenic-Containing Nosiheptide Analogues.
Topics: Anti-Bacterial Agents; Thiazoles; Thiophenes | 2022 |
11 trial(s) available for thiazoles and thiophenes
| Article | Year |
|---|---|
An open-label 52-week clinical extension comparing duloxetine with routine care in patients with diabetic peripheral neuropathic pain.
Topics: Acetaminophen; Amitriptyline; Analgesics; Carbamazepine; Diabetes Complications; Diabetic Neuropathies; Diclofenac; Double-Blind Method; Duloxetine Hydrochloride; Female; Humans; Lipids; Male; Meloxicam; Middle Aged; Neuralgia; Pentoxifylline; Selective Serotonin Reuptake Inhibitors; Thiamine; Thiazines; Thiazoles; Thioctic Acid; Thiophenes; Time; Vitamin B 12 | 2007 |
A randomized trial of avatrombopag, an investigational thrombopoietin-receptor agonist, in persistent and chronic immune thrombocytopenia.
Topics: Administration, Oral; Adult; Aged; Chronic Disease; Dose-Response Relationship, Drug; Double-Blind Method; Drugs, Investigational; Epistaxis; Fatigue; Female; Headache; Humans; Male; Middle Aged; Platelet Count; Purpura, Thrombocytopenic, Idiopathic; Receptors, Thrombopoietin; Thiazoles; Thiophenes; Time Factors; Treatment Outcome | 2014 |
Phase II study of avatrombopag in thrombocytopenic patients with cirrhosis undergoing an elective procedure.
Topics: Blood Platelets; Dose-Response Relationship, Drug; Double-Blind Method; Elective Surgical Procedures; Fatigue; Female; Headache; Humans; Incidence; Liver Cirrhosis; Male; Middle Aged; Nausea; Platelet Count; Receptors, Thrombopoietin; Risk Factors; Thiazoles; Thiophenes; Thrombocytopenia | 2014 |
In vitro antiviral activity and preclinical and clinical resistance profile of miravirsen, a novel anti-hepatitis C virus therapeutic targeting the human factor miR-122.
Topics: 5' Untranslated Regions; Antiviral Agents; Carbamates; Cyclohexanols; Drug Resistance, Viral; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Humans; Imidazoles; Macrocyclic Compounds; MicroRNAs; Molecular Targeted Therapy; Mutation; Oligonucleotides; Oligopeptides; Pyrrolidines; Quinolines; Replicon; Thiazoles; Thiophenes; Valine | 2015 |
Pharmacokinetics, Pharmacodynamics, Pharmacogenomics, Safety, and Tolerability of Avatrombopag in Healthy Japanese and White Subjects.
Topics: Adult; Asian People; Cytochrome P-450 CYP2C9; Fasting; Female; Food-Drug Interactions; Genotype; Humans; Male; Middle Aged; Platelet Count; Receptors, Thrombopoietin; Thiazoles; Thiophenes; White People; Young Adult | 2018 |
Pharmacokinetic/pharmacodynamic drug-drug interactions of avatrombopag when coadministered with dual or selective CYP2C9 and CYP3A interacting drugs.
Topics: Adolescent; Adult; Cytochrome P-450 CYP2C9 Inducers; Cytochrome P-450 CYP2C9 Inhibitors; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Female; Fluconazole; Healthy Volunteers; Humans; Itraconazole; Male; Middle Aged; Platelet Count; Receptors, Thrombopoietin; Rifampin; Thiazoles; Thiophenes; Young Adult | 2018 |
Avatrombopag, an oral thrombopoietin receptor agonist: results of two double-blind, dose-rising, placebo-controlled Phase 1 studies.
Topics: Adolescent; Adult; Aged; Double-Blind Method; Female; Humans; Male; Middle Aged; Receptors, Thrombopoietin; Thiazoles; Thiophenes; Thrombocytopenia | 2018 |
Avatrombopag increases platelet count but not platelet activation in patients with thrombocytopenia resulting from liver disease.
Topics: Blood Platelets; Chronic Disease; Double-Blind Method; Hematologic Agents; Humans; Liver Diseases; Platelet Activation; Platelet Count; Thiazoles; Thiophenes; Thrombocytopenia; Thrombopoiesis; Time Factors; Treatment Outcome; United States | 2018 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor Proteins, Signal Transducing; Adenine; Adenocarcinoma; Adipogenesis; Administration, Cutaneous; Administration, Ophthalmic; Adolescent; Adsorption; Adult; Aeromonas hydrophila; Aerosols; Aged; Aged, 80 and over; Aging; Agriculture; Air Pollutants; Air Pollution; Airway Remodeling; Alanine Transaminase; Albuminuria; Aldehyde Dehydrogenase 1 Family; Algorithms; AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase; Alzheimer Disease; Amino Acid Sequence; Ammonia; Ammonium Compounds; Anaerobiosis; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Antibodies, Antineutrophil Cytoplasmic; Antibodies, Monoclonal, Humanized; Antifungal Agents; Antigens, Bacterial; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antitubercular Agents; Antiviral Agents; Apolipoproteins E; Apoptosis; Arabidopsis; Arabidopsis Proteins; Arsenic; Arthritis, Rheumatoid; Asthma; Atherosclerosis; ATP-Dependent Proteases; Attitude of Health Personnel; Australia; Austria; Autophagy; Axitinib; Bacteria; Bacterial Outer Membrane Proteins; Bacterial Proteins; Bacterial Toxins; Bacterial Typing Techniques; Bariatric Surgery; Base Composition; Bayes Theorem; Benzoxazoles; Benzylamines; beta Catenin; Betacoronavirus; Betula; Binding Sites; Biological Availability; Biological Oxygen Demand Analysis; Biomarkers; Biomarkers, Tumor; Biopsy; Bioreactors; Biosensing Techniques; Birth Weight; Blindness; Blood Chemical Analysis; Blood Gas Analysis; Blood Glucose; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Blood-Brain Barrier; Blotting, Western; Body Mass Index; Body Weight; Bone and Bones; Bone Density; Bone Resorption; Borates; Brain; Brain Infarction; Brain Injuries, Traumatic; Brain Neoplasms; Breakfast; Breast Milk Expression; Breast Neoplasms; Bronchi; Bronchoalveolar Lavage Fluid; Buffaloes; Cadherins; Calcification, Physiologic; Calcium Compounds; Calcium, Dietary; Cannula; Caprolactam; Carbon; Carbon Dioxide; Carboplatin; Carcinogenesis; Carcinoma, Ductal; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Cardiovascular Diseases; Carps; Carrageenan; Case-Control Studies; Catalysis; Catalytic Domain; Cattle; CD8-Positive T-Lymphocytes; Cell Adhesion; Cell Cycle Proteins; Cell Death; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Phone Use; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Cellulose; Chemical Phenomena; Chemoradiotherapy; Child; Child Development; Child, Preschool; China; Chitosan; Chlorocebus aethiops; Cholecalciferol; Chromatography, Liquid; Circadian Clocks; Circadian Rhythm; Circular Dichroism; Cisplatin; Citric Acid; Clinical Competence; Clinical Laboratory Techniques; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clostridioides difficile; Clostridium Infections; Coculture Techniques; Cohort Studies; Cold Temperature; Colitis; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type XI; Color; Connective Tissue Diseases; Copper; Coronary Angiography; Coronavirus 3C Proteases; Coronavirus Infections; Cost of Illness; Counselors; COVID-19; COVID-19 Testing; Creatine Kinase; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Cryoelectron Microscopy; Cryosurgery; Crystallography, X-Ray; Cues; Cultural Competency; Cultural Diversity; Curriculum; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase Inhibitor p21; Cycloparaffins; Cysteine Endopeptidases; Cytokines; Cytoplasm; Cytoprotection; Databases, Factual; Denitrification; Deoxycytidine; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diagnosis, Differential; Diatoms; Diet; Diet, High-Fat; Dietary Exposure; Diffusion Magnetic Resonance Imaging; Diketopiperazines; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Disease Progression; Disease-Free Survival; DNA; DNA Damage; DNA Glycosylases; DNA Repair; DNA-Binding Proteins; DNA, Bacterial; DNA, Viral; Docetaxel; Dose Fractionation, Radiation; Dose-Response Relationship, Drug; Down-Regulation; Doxorubicin; Drosophila; Drosophila melanogaster; Drug Carriers; Drug Delivery Systems; Drug Liberation; Drug Repositioning; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Drug Therapy, Combination; Edema; Edible Grain; Education, Graduate; Education, Medical, Graduate; Education, Pharmacy; Ehlers-Danlos Syndrome; Electron Transport Complex III; Electron Transport Complex IV; Electronic Nicotine Delivery Systems; Emergency Service, Hospital; Empathy; Emulsions; Endothelial Cells; Endurance Training; Energy Intake; Enterovirus A, Human; Environment; Environmental Monitoring; Enzyme Assays; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Epoxide Hydrolases; Epoxy Compounds; Erythrocyte Count; Erythrocytes; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Esophagectomy; Estrogens; Etanercept; Ethiopia; Ethnicity; Ethylenes; Exanthema; Exercise; Exercise Test; Exercise Tolerance; Extracellular Matrix; Extracorporeal Membrane Oxygenation; Eye Infections, Fungal; False Negative Reactions; Fatty Acids; Fecal Microbiota Transplantation; Feces; Female; Femur Neck; Fermentation; Ferritins; Fetal Development; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Fibroblasts; Fibroins; Fish Proteins; Flavanones; Flavonoids; Focus Groups; Follow-Up Studies; Food Handling; Food Supply; Food, Formulated; Forced Expiratory Volume; Forests; Fractures, Bone; Fruit and Vegetable Juices; Fusobacteria; G1 Phase Cell Cycle Checkpoints; G2 Phase Cell Cycle Checkpoints; Gamma Rays; Gastrectomy; Gastrointestinal Microbiome; Gastrointestinal Stromal Tumors; Gefitinib; Gels; Gemcitabine; Gene Amplification; Gene Expression; Gene Expression Regulation; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Plant; Gene Knockdown Techniques; Gene-Environment Interaction; Genotype; Germany; Glioma; Glomerular Filtration Rate; Glucagon; Glucocorticoids; Glycemic Control; Glycerol; Glycogen Synthase Kinase 3 beta; Glycolipids; Glycolysis; Goblet Cells; Gram-Negative Bacterial Infections; Granulocyte Colony-Stimulating Factor; Graphite; Greenhouse Effect; Guanidines; Haemophilus influenzae; HCT116 Cells; Health Knowledge, Attitudes, Practice; Health Personnel; Health Services Accessibility; Health Services Needs and Demand; Health Status Disparities; Healthy Volunteers; Heart Failure; Heart Rate; Heart Transplantation; Heart-Assist Devices; HEK293 Cells; Heme; Heme Oxygenase-1; Hemolysis; Hemorrhage; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hepatocytes; Hexoses; High-Throughput Nucleotide Sequencing; Hippo Signaling Pathway; Histamine; Histamine Agonists; Histidine; Histone Deacetylase 2; HIV Infections; HIV Reverse Transcriptase; HIV-1; Homebound Persons; Homeodomain Proteins; Homosexuality, Male; Hospice and Palliative Care Nursing; HSP70 Heat-Shock Proteins; Humans; Hyaluronan Receptors; Hydrogen; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrolysis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemia; Hypoglycemic Agents; Hypoxia; Idiopathic Interstitial Pneumonias; Imaging, Three-Dimensional; Imatinib Mesylate; Immunotherapy; Implementation Science; Incidence; INDEL Mutation; Induced Pluripotent Stem Cells; Industrial Waste; Infant; Infant, Newborn; Inflammation; Inflammation Mediators; Infliximab; Infusions, Intravenous; Inhibitory Concentration 50; Injections; Insecticides; Insulin-Like Growth Factor Binding Protein 5; Insulin-Secreting Cells; Interleukin-1; Interleukin-17; Interleukin-8; Internship and Residency; Intestines; Intracellular Signaling Peptides and Proteins; Ion Transport; Iridaceae; Iridoid Glucosides; Islets of Langerhans Transplantation; Isodon; Isoflurane; Isotopes; Italy; Joint Instability; Ketamine; Kidney; Kidney Failure, Chronic; Kidney Function Tests; Kidney Neoplasms; Kinetics; Klebsiella pneumoniae; Knee Joint; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Lactate Dehydrogenase 5; Laparoscopy; Laser Therapy; Lasers, Semiconductor; Lasers, Solid-State; Laurates; Lead; Leukocyte L1 Antigen Complex; Leukocytes, Mononuclear; Light; Lipid Peroxidation; Lipopolysaccharides; Liposomes; Liver; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Locomotion; Longitudinal Studies; Lopinavir; Lower Urinary Tract Symptoms; Lubricants; Lung; Lung Diseases, Interstitial; Lung Neoplasms; Lymphocyte Activation; Lymphocytes, Tumor-Infiltrating; Lymphoma, Mantle-Cell; Lysosomes; Macrophages; Male; Manganese Compounds; MAP Kinase Kinase 4; Mass Screening; Maternal Health; Medicine, Chinese Traditional; Melanoma, Experimental; Memantine; Membrane Glycoproteins; Membrane Proteins; Mesenchymal Stem Cell Transplantation; Metal Nanoparticles; Metalloendopeptidases; Metalloporphyrins; Methadone; Methane; Methicillin-Resistant Staphylococcus aureus; Mexico; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Mice, Nude; Mice, SCID; Mice, Transgenic; Microarray Analysis; Microbial Sensitivity Tests; Microbiota; Micronutrients; MicroRNAs; Microscopy, Confocal; Microsomes, Liver; Middle Aged; Milk; Milk, Human; Minority Groups; Mitochondria; Mitochondrial Membranes; Mitochondrial Proteins; Models, Animal; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Epidemiology; Molecular Structure; Molecular Weight; Multilocus Sequence Typing; Multimodal Imaging; Muscle Strength; Muscle, Skeletal; Muscular Diseases; Mutation; Mycobacterium tuberculosis; Myocardial Stunning; Myristates; NAD(P)H Dehydrogenase (Quinone); Nanocomposites; Nanogels; Nanoparticles; Nanotechnology; Naphthalenes; Nasal Cavity; National Health Programs; Necrosis; Needs Assessment; Neoadjuvant Therapy; Neonicotinoids; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasm Transplantation; Neoplasms; Neoplastic Stem Cells; Netherlands; Neuroblastoma; Neuroprotective Agents; Neutrophils; NF-kappa B; NFATC Transcription Factors; Nicotiana; Nicotine; Nitrates; Nitrification; Nitrites; Nitro Compounds; Nitrogen; Nitrogen Dioxide; North Carolina; Nuclear Magnetic Resonance, Biomolecular; Nuclear Proteins; Nucleic Acid Hybridization; Nucleosomes; Nutrients; Obesity; Obesity, Morbid; Oceans and Seas; Oncogene Protein v-akt; Oncogenes; Oocytes; Open Reading Frames; Osteoclasts; Osteogenesis; Osteoporosis; Osteoporosis, Postmenopausal; Outpatients; Ovarian Neoplasms; Ovariectomy; Overweight; Oxazines; Oxidants; Oxidation-Reduction; Oxidative Stress; Oxides; Oxidoreductases; Oxygen; Oxygen Inhalation Therapy; Oxygenators, Membrane; Ozone; Paclitaxel; Paenibacillus; Pain Measurement; Palliative Care; Pancreatic Neoplasms; Pandemics; Parasympathetic Nervous System; Particulate Matter; Pasteurization; Patient Preference; Patient Satisfaction; Pediatric Obesity; Permeability; Peroxiredoxins; Peroxynitrous Acid; Pharmaceutical Services; Pharmacists; Pharmacy; Phaseolus; Phenotype; Phoeniceae; Phosphates; Phosphatidylinositol 3-Kinases; Phospholipid Transfer Proteins; Phospholipids; Phosphorus; Phosphorylation; Photoperiod; Photosynthesis; Phylogeny; Physical Endurance; Physicians; Pilot Projects; Piperidines; Pituitary Adenylate Cyclase-Activating Polypeptide; Plant Extracts; Plant Leaves; Plant Proteins; Plant Roots; Plaque, Atherosclerotic; Pneumonia; Pneumonia, Viral; Point-of-Care Testing; Polyethylene Glycols; Polymers; Polysorbates; Pore Forming Cytotoxic Proteins; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Postprandial Period; Poverty; Pre-Exposure Prophylaxis; Prediabetic State; Predictive Value of Tests; Pregnancy; Pregnancy Trimester, First; Pregnancy, High-Risk; Prenatal Exposure Delayed Effects; Pressure; Prevalence; Primary Graft Dysfunction; Primary Health Care; Professional Role; Professionalism; Prognosis; Progression-Free Survival; Prolactin; Promoter Regions, Genetic; Proof of Concept Study; Proportional Hazards Models; Propylene Glycol; Prospective Studies; Prostate; Protein Binding; Protein Biosynthesis; Protein Isoforms; Protein Kinase Inhibitors; Protein Phosphatase 2; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein Transport; Proteoglycans; Proteome; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins c-ret; Proto-Oncogene Proteins p21(ras); Proton Pumps; Protons; Protoporphyrins; Pseudomonas aeruginosa; Pseudomonas fluorescens; Pulmonary Artery; Pulmonary Disease, Chronic Obstructive; Pulmonary Gas Exchange; Pulmonary Veins; Pyrazoles; Pyridines; Pyrimidines; Qualitative Research; Quinoxalines; Rabbits; Random Allocation; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Histamine H3; Receptors, Immunologic; Receptors, Transferrin; Recombinant Proteins; Recurrence; Reference Values; Referral and Consultation; Regional Blood Flow; Registries; Regulon; Renal Insufficiency, Chronic; Reperfusion Injury; Repressor Proteins; Reproducibility of Results; Republic of Korea; Research Design; Resistance Training; Respiration, Artificial; Respiratory Distress Syndrome; Respiratory Insufficiency; Resuscitation; Retinal Dehydrogenase; Retreatment; Retrospective Studies; Reverse Transcriptase Inhibitors; Rhinitis, Allergic; Ribosomal Proteins; Ribosomes; Risk Assessment; Risk Factors; Ritonavir; Rivers; RNA Interference; RNA-Seq; RNA, Messenger; RNA, Ribosomal, 16S; RNA, Small Interfering; Rosuvastatin Calcium; Rural Population; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salivary Ducts; Salivary Gland Neoplasms; San Francisco; SARS-CoV-2; Satiation; Satiety Response; Schools; Schools, Pharmacy; Seasons; Seawater; Selection, Genetic; Sequence Analysis, DNA; Serine-Threonine Kinase 3; Sewage; Sheep; Sheep, Domestic; Shock, Hemorrhagic; Signal Transduction; Silver; Silymarin; Single Photon Emission Computed Tomography Computed Tomography; Sirolimus; Sirtuin 1; Skin; Skin Neoplasms; Skin Physiological Phenomena; Sleep Initiation and Maintenance Disorders; Social Class; Social Participation; Social Support; Soil; Soil Microbiology; Solutions; Somatomedins; Soot; Specimen Handling; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis; Spinal Fractures; Spirometry; Staphylococcus aureus; STAT1 Transcription Factor; STAT3 Transcription Factor; Streptomyces coelicolor; Stress, Psychological; Stroke; Stroke Volume; Structure-Activity Relationship; Students, Medical; Students, Pharmacy; Substance Abuse Treatment Centers; Sulfur Dioxide; Surface Properties; Surface-Active Agents; Surveys and Questionnaires; Survival Analysis; Survival Rate; Survivin; Sweden; Swine; Swine, Miniature; Sympathetic Nervous System; T-Lymphocytes, Regulatory; Talaromyces; Tandem Mass Spectrometry; tau Proteins; Telemedicine; Telomerase; Telomere; Telomere Homeostasis; Temperature; Terminally Ill; Th1 Cells; Thiamethoxam; Thiazoles; Thiophenes; Thioredoxin Reductase 1; Thrombosis; Thulium; Thyroid Cancer, Papillary; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Time Factors; Titanium; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transcriptome; Transforming Growth Factor beta1; Transistors, Electronic; Translational Research, Biomedical; Transplantation Tolerance; Transplantation, Homologous; Transportation; Treatment Outcome; Tretinoin; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary; Tubulin Modulators; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Twins; Ultrasonic Therapy; Ultrasonography; Ultraviolet Rays; United States; Up-Regulation; Uranium; Urethra; Urinary Bladder; Urodynamics; Uromodulin; Uveitis; Vasoconstrictor Agents; Ventricular Function, Left; Vero Cells; Vesicular Transport Proteins; Viral Nonstructural Proteins; Visual Acuity; Vital Capacity; Vitamin D; Vitamin D Deficiency; Vitamin K 2; Vitamins; Volatilization; Voriconazole; Waiting Lists; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical; Whole Genome Sequencing; Wine; Wnt Signaling Pathway; Wound Healing; Wounds and Injuries; WW Domains; X-linked Nuclear Protein; X-Ray Diffraction; Xanthines; Xenograft Model Antitumor Assays; YAP-Signaling Proteins; Yogurt; Young Adult; Zebrafish; Zebrafish Proteins; Ziziphus | 2016 |
Efficacy and safety evaluation of avatrombopag in immune thrombocytopenia: analyses of a phase III study and long-term extension.
Topics: Double-Blind Method; Female; Humans; Male; Purpura, Thrombocytopenic, Idiopathic; Receptors, Thrombopoietin; Thiazoles; Thiophenes | 2022 |
Avatrombopag for chemotherapy-induced thrombocytopenia in patients with non-haematological malignancies: an international, randomised, double-blind, placebo-controlled, phase 3 trial.
Topics: Adolescent; Anemia; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Double-Blind Method; Humans; Neutropenia; Thiazoles; Thiophenes; Thrombocytopenia; Treatment Outcome | 2022 |
234 other study(ies) available for thiazoles and thiophenes
| Article | Year |
|---|---|
Highly selective inhibitors of thromboxane synthetase. 2. Pyridine derivatives.
Topics: Animals; Oxidoreductases; Pyridines; Sheep; Structure-Activity Relationship; Thromboxane-A Synthase | 1981 |
Antiprotozoal Thiazoles. 2-(5-Nitro-2-thienyl)thiazoles.
Topics: Administration, Oral; Animals; Chagas Disease; Injections, Intraperitoneal; Lethal Dose 50; Mice; Nitro Compounds; Thiazoles; Thiophenes; Trypanocidal Agents; Trypanosomiasis, African | 1975 |
Antimicrobial agents. XXV. Antifungal activity of 2-aminobenzthiazol derivatives.
Topics: Antifungal Agents; Arthrodermataceae; Fungi; Nitrofurans; Thiazoles; Thiophenes; Yeasts | 1976 |
Volatile sulfur compounds contributing to meat flavour. Part. I. Components identified in boiled meat.
Topics: Hot Temperature; Meat; Sulfhydryl Compounds; Sulfides; Taste; Thiazoles; Thiophenes | 1976 |
Mutagenicity of nitrofurans, nitrothiophenes, nitropyrroles, nitroimidazole, aminothiophenes, and aminothiazoles in Salmonella typhimurium.
Topics: Amines; DNA Repair; DNA, Bacterial; Heterocyclic Compounds; Mutagens; Nitro Compounds; Nitrofurans; Nitroimidazoles; Pyrroles; Salmonella typhimurium; Structure-Activity Relationship; Thiazoles; Thiophenes | 1975 |
[Heterocyclic o-amino-phosphonic esters (author's transl)].
Topics: Heterocyclic Compounds; Organophosphonates; Oxazoles; Pyrimidines; Thiazoles; Thiophenes | 1975 |
Synthesis and antimicrobial activity of some thiazolinyl tetrahydrobenzo[b]thiophenes and thiazolinyl tetrahydrobenzothieno[2,3-d]pyrimidin-4-ones.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antifungal Agents; Candida albicans; Escherichia coli; Microbial Sensitivity Tests; Nystatin; Pyrimidinones; Staphylococcus aureus; Thiazoles; Thiophenes | 1992 |
Benzo[b]thiophenes, Part I: Synthesis and antimicrobial activity of benzo[b]thienyl-1,3,4-oxadiazole, -1,2,4-triazoline, and -thiazoline derivatives.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bacteria; Candida albicans; Microbial Sensitivity Tests; Oxadiazoles; Thiazoles; Thiophenes; Triazoles | 1992 |
Differential effects of oltipraz and its oxy-analogue on the viability of Schistosoma mansoni and the activity of glutathione S-transferase.
Topics: Animals; Dinitrochlorobenzene; Female; Glutathione; Glutathione Transferase; Kinetics; Male; Mice; Pyrazines; Schistosoma mansoni; Schistosomiasis mansoni; Schistosomicides; Tetrazolium Salts; Thiazoles; Thiones; Thiophenes | 1991 |
Synthesis and pharmacological properties of 3-alkylthio derivatives of isothiazolothieno-1,2,3-triazine.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents; Behavior, Animal; Fungi; Histamine Antagonists; Lethal Dose 50; Male; Mice; Microbial Sensitivity Tests; Rats; Rats, Inbred Strains; Thiazoles; Thiophenes; Triazines | 1991 |
Studies on cardiotonic agents. VI. Synthesis of novel 4,5-dihydro-3(2H)-pyridazinone derivatives carrying some benzoheterocycles at the 6-position.
Topics: Animals; Cardiotonic Agents; Dogs; Imidazoles; Myocardial Contraction; Pyridazines; Quinazolines; Thiazoles; Thiophenes | 1991 |
Synthesis and cardiotonic activity of novel biimidazoles.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Amrinone; Animals; Blood Pressure; Cardiotonic Agents; Chemical Phenomena; Chemistry; Dogs; Furans; Heart Rate; Imidazoles; Isoenzymes; Milrinone; Molecular Structure; Myocardial Contraction; Pyridones; Rats; Stimulation, Chemical; Structure-Activity Relationship; Thiazoles; Thiophenes | 1990 |
Thiophene-degrading Escherichia coli mutants possess sulfone oxidase activity and show altered resistance to sulfur-containing antibiotics.
Topics: Anti-Bacterial Agents; Bacterial Proteins; Dapsone; Drug Resistance, Microbial; Escherichia coli; Furans; Genes, Bacterial; Oxidation-Reduction; Oxidoreductases; Oxidoreductases Acting on Sulfur Group Donors; Pyrrolidinones; Substrate Specificity; Sulfones; Sulfoxides; Thiazoles; Thiophenes | 1990 |
Syntheses and gastric acid antisecretory properties of the H2-receptor antagonist. N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]thieno[3,4-d]isot hiazol-3-amine 1,1-dioxide and related derivatives.
Topics: Animals; Atrial Function; Chemical Phenomena; Chemistry; Dogs; Dose-Response Relationship, Drug; Female; Gastric Acid; Gastric Mucosa; Guinea Pigs; Heart Atria; Heart Rate; Histamine; Histamine H2 Antagonists; Ligation; Male; Phenoxypropanolamines; Pylorus; Ranitidine; Rats; Structure-Activity Relationship; Thiazoles; Thiophenes | 1988 |
Topical carbonic anhydrase inhibitors.
Topics: Administration, Topical; Benzothiazoles; Carbonic Anhydrase Inhibitors; Ethoxzolamide; Gels; Glaucoma; Humans; Intraocular Pressure; Ocular Hypertension; Sulfonamides; Thiazoles; Thiophenes | 1989 |
Species difference in the specific receptors of platelet activating factor.
Topics: Animals; Benzofurans; Blood Platelets; Cell Membrane; Diterpenes; Furans; Ginkgolides; Humans; Lactones; Lignans; Lung; Phospholipid Ethers; Plant Extracts; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Species Specificity; Thiazoles; Thiophenes | 1986 |
[Synthesis and antifungal activity of new derivatives of 5-(4-halobenzoyl)-4-amino-3-(2-dialkylaminoethylthio)thieno [2,3-c] and [3,2-d] isothiazole].
Topics: Antifungal Agents; Benzoates; Chemical Phenomena; Chemistry; Thiazoles; Thiophenes | 1988 |
Ocular distribution studies of the topical carbonic anhydrase inhibitors L-643,799 and L-650,719 and related alkyl prodrugs.
Topics: Administration, Topical; Animals; Aqueous Humor; Carbonic Anhydrase Inhibitors; Chromatography, High Pressure Liquid; Ciliary Body; Conjunctiva; Cornea; Ethoxzolamide; Eye; Iris; Prodrugs; Rabbits; Tears; Thiazoles; Thiophenes | 1988 |
Synthetic penicillins. Heterocyclic analogs of ampicillin. Structure-activity relationships.
Topics: Ampicillin; Bacillus subtilis; Chromatography, Paper; Escherichia coli; Glycine; Microbial Sensitivity Tests; Penicillins; Salmonella enteritidis; Shigella dysenteriae; Spectrophotometry, Infrared; Staphylococcus; Structure-Activity Relationship; Thiazoles; Thiophenes | 1973 |
Studies on fungicides. XXV. Addition reaction of dithiocarbamates to fumaronitrile, bis(alkylthio)maleonitrile, 2,3-dicyano-5,6-dihydro-1,4-dithiin and 4,5-dicyano-2-oxo-1,4-dithiole.
Topics: Carbamates; Chemical Phenomena; Chemistry; Fungicides, Industrial; Nitriles; Thiazoles; Thiophenes | 1974 |
Helminth control in grazing sheep: periodic treatment with levamisole, morantel, cambendazole, and mebendazole.
Topics: Administration, Oral; Animals; Anthelmintics; Benzimidazoles; Benzoates; Carbamates; Cestode Infections; Haemonchiasis; Helminthiasis; Helminthiasis, Animal; Hematocrit; Levamisole; Oesophagostomiasis; Pyrimidines; Sheep; Sheep Diseases; Strongyloidiasis; Thiazoles; Thiophenes; Trichostrongyloidiasis; Trichuriasis | 1974 |
The fumarate reductase reaction of Haemonchus contortus and the mode of action of some anthelmintics.
Topics: Animals; Anthelmintics; Benzimidazoles; Benzoates; Carbamates; Carbon Isotopes; Drug Resistance; Fumarates; Iodine; Mitochondria; Nitrophenols; Oxidoreductases; Pyrimidines; Spectrophotometry; Succinates; Thiabendazole; Thiazoles; Thiophenes; Trichostrongyloidea | 1973 |
Radiation chemistry of nitrogen and sulfur heterocyclics.
Topics: Chromatography, Gas; Free Radicals; Heterocyclic Compounds; Imidazoles; Nitrogen; Pyrazines; Pyrazoles; Pyrimidines; Pyrroles; Radiochemistry; Sulfur; Tetrazoles; Thiazoles; Thiophenes; Triazines; Triazoles | 1973 |
Equilibrium and kinetic effects of sixteen compounds on the forms of horse heart ferricytochrome c.
Topics: Acid-Base Equilibrium; Adenine Nucleotides; Adenosine Triphosphate; Aniline Compounds; Animals; Antimycin A; Azides; Barbiturates; Benzimidazoles; Cytochromes; Horses; Hydantoins; Hydrogen-Ion Concentration; Imidazoles; Iron; Kinetics; Myocardium; Nitrophenols; Oxidation-Reduction; Protein Binding; Pyrimidines; Pyrrolidines; Thiazoles; Thiophenes | 1972 |
Anthelmintic activity in sheep of some compounds related to pyrantel and morantel.
Topics: Amidines; Animals; Anthelmintics; Nematode Infections; Pyridinium Compounds; Pyrimidines; Sheep; Sheep Diseases; Structure-Activity Relationship; Thiazines; Thiazoles; Thiophenes | 1972 |
Toxicological and pharmacological relations between levamisole, pyrantel and diethylcarbamazine and their significance in helminth chemotherapy.
Topics: Animals; Anthelmintics; Blood Pressure; Diethylcarbamazine; Dogs; Hexamethonium Compounds; Imidazoles; Phentolamine; Pyrimidines; Respiration; Thiazoles; Thiophenes | 1972 |
Pteridines. 8. Some 2,4,7-triamino-6-heteroarylpteridines.
Topics: Chromatography, Paper; Furans; Hydrogen-Ion Concentration; Imidazoles; Oxazoles; Pteridines; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Spectrum Analysis; Thiazoles; Thiophenes; Triazoles; Ultraviolet Rays | 1968 |
Carcinogenic nitrogen compounds. LX. New nitrogen heterocycles bearing a selenophen, thiophen, thiazole, or pyrazole ring.
Topics: Animals; Carcinogens; Chemical Phenomena; Chemistry; Heterocyclic Compounds; Nitrogen; Pyrazoles; Rats; Selenium; Thiazoles; Thiophenes | 1968 |
Dopamine receptor agonist potencies for inhibition of cell firing correlate with dopamine D3 receptor binding affinities.
Topics: Aminoquinolines; Animals; Apomorphine; Azepines; Benzothiazoles; Binding, Competitive; CHO Cells; Cricetinae; Dopamine Agonists; Dose-Response Relationship, Drug; Ergolines; Imidazoles; Male; Neurons; Phenethylamines; Piperidines; Pramipexole; Quinolines; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Structure-Activity Relationship; Substantia Nigra; Tetrahydronaphthalenes; Thiazoles; Thiophenes; Transfection | 1995 |
Genotoxicity of 1,3-dithiane and 1,4-dithiane in the CHO/SCE assay and the Salmonella/microsomal test.
Topics: Animals; Biotransformation; CHO Cells; Cricetinae; Furans; Heterocyclic Compounds; Imidazoles; Maillard Reaction; Mutagenicity Tests; Mutagens; Pyrazines; Pyridines; Pyrroles; Salmonella typhimurium; Sister Chromatid Exchange; Sulfur Compounds; Thiazoles; Thiophenes | 1994 |
The potent activity of the 5-HT1A receptor agonists, S 14506 and S 14671, in the rat forced swim test is blocked by novel 5-HT1A receptor antagonists.
Topics: Animals; Antidepressive Agents; Benzamides; Fenclonine; Indoles; Male; Piperazines; Rats; Rats, Wistar; Serotonin Antagonists; Serotonin Receptor Agonists; Swimming; Thiazoles; Thiophenes | 1994 |
Electron impact mass spectra of some 1-(2-furyl)- and 1-(2-thienyl)-2-(2-benzothiazolyl)ethenes.
Topics: Furans; Gas Chromatography-Mass Spectrometry; Thiazoles; Thiophenes | 1995 |
The chemistry of pseudomonic acid. Part 14. Synthesis and in vivo biological activity of heterocyclyl substituted oxazole derivatives.
Topics: Animals; Anti-Bacterial Agents; Furans; Humans; Isoxazoles; Mice; Mupirocin; Oxazoles; Pyrazoles; Pyridines; Sepsis; Staphylococcal Infections; Thiazoles; Thiophenes | 1995 |
1,2-Dithiolan-3-one 1-oxides: a class of thiol-activated DNA-cleaving agents that are structurally related to the natural product leinamycin.
Topics: Antibiotics, Antineoplastic; DNA; Lactams; Macrolides; Reactive Oxygen Species; Sulfhydryl Compounds; Thiazoles; Thiones; Thiophenes | 1996 |
Effects of 5-lipoxygenase inhibitors on interleukin production by human synovial tissues in organ culture: comparison with interleukin-1-synthesis inhibitors.
Topics: Animals; Benzofurans; Enzyme-Linked Immunosorbent Assay; Hip Joint; Humans; Hydroxyurea; Indoles; Interleukin-1; Knee Joint; Lipoxygenase Inhibitors; Naphthalenes; Organ Culture Techniques; Oxindoles; Pyrazoles; Quinolines; Structure-Activity Relationship; Swine; Synovial Membrane; Tarsus, Animal; Thiazoles; Thiophenes | 1996 |
Influence of advanced glycation end-products and AGE-inhibitors on nucleation-dependent polymerization of beta-amyloid peptide.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Carnosine; Cognition; Cross-Linking Reagents; Fructose; Glycation End Products, Advanced; Guanidines; Humans; Memory; Neuropeptide Y; Particle Size; Peptide Fragments; Piperazines; Protein Structure, Secondary; Solubility; Temperature; Thiazoles; Thiophenes | 1997 |
Thiols and selenium: protective effect on human skin fibroblasts exposed to UVA radiation.
Topics: Acetylcysteine; Antioxidants; Cell Survival; Cells, Cultured; Cysteine; Dose-Response Relationship, Radiation; Female; Fibroblasts; Glutathione; Humans; Pyrrolidonecarboxylic Acid; Radiation-Protective Agents; Skin; Sodium Selenite; Surgery, Plastic; Thiazoles; Thiazolidines; Thiophenes; Ultraviolet Rays | 1997 |
New azole antifungals. 2. Synthesis and antifungal activity of heterocyclecarboxamide derivatives of 3-amino-2-aryl-1-azolyl-2-butanol.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Candidiasis; Colony Count, Microbial; Fungi; Male; Mice; Molecular Conformation; Pyrimidinones; Rats; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Thiophenes; Triazoles | 1998 |
Novel triazole 2'-deoxy-4'-thionucleosides: stereoselective synthesis and biological evaluation.
Topics: Anti-HIV Agents; Antiviral Agents; Cytomegalovirus; Herpesvirus 1, Human; Herpesvirus 2, Human; Herpesvirus 3, Human; HIV-1; Humans; Indicators and Reagents; Microbial Sensitivity Tests; Nucleosides; Stereoisomerism; Thiazoles; Thiophenes | 1999 |
Sultamo-steroid analogues, Part VII: Synthesis of epi-androsterone derivatives with potential activity.
Topics: Androsterone; Animals; Antineoplastic Agents; Pyridines; Thiazoles; Thiophenes; Tumor Cells, Cultured | 1999 |
Synthesis of thiophene-2-carboxamidines containing 2-aminothiazoles and their biological evaluation as urokinase inhibitors.
Topics: Amidines; Drug Design; Drug Evaluation, Preclinical; Plasminogen Activators; Structure-Activity Relationship; Thiazoles; Thiophenes; Urokinase-Type Plasminogen Activator | 2001 |
Reduction of cerebrospinal fluid amyloid beta after systemic administration of M1 muscarinic agonists.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cerebrospinal Fluid; Female; Muscarinic Agonists; Neurons; Peptide Fragments; Piperidines; Quinuclidines; Rabbits; Receptor, Muscarinic M1; Receptors, Muscarinic; Thiazoles; Thiophenes | 2001 |
The reaction of digitoxin and digoxin with cyanoacetic acid hydrazide: synthesis of coumarin, thiazole, thiophene and pyridine derivatives with potential biological activities.
Topics: Coumarins; Digitoxin; Digoxin; Hydrazines; Indicators and Reagents; Magnetic Resonance Spectroscopy; Pyridines; Thiazoles; Thiophenes | 2001 |
Anti-Helicobacter pylori agents. 5. 2-(Substituted guanidino)-4-arylthiazoles and aryloxazole analogues.
Topics: Animals; Anti-Bacterial Agents; Colony Count, Microbial; Gastric Juice; Guanidines; Guinea Pigs; Helicobacter pylori; Histamine H2 Antagonists; In Vitro Techniques; Male; Microbial Sensitivity Tests; Myocardium; Oxazoles; Rats; Structure-Activity Relationship; Thiazoles; Thiophenes | 2002 |
Design and synthesis of 4,5-disubstituted-thiophene-2-amidines as potent urokinase inhibitors.
Topics: Alkylation; Amidines; Indicators and Reagents; Lithium Compounds; Protein Binding; Serine Proteinase Inhibitors; Structure-Activity Relationship; Thiazoles; Thiophenes; Urokinase-Type Plasminogen Activator | 2002 |
6,7-Dihydro-2-benzothiophen-4(5H)-ones: a novel class of GABA-A alpha5 receptor inverse agonists.
Topics: Animals; Cells, Cultured; Cognition; GABA-A Receptor Agonists; Humans; Ketones; Mice; Thiazoles; Thiophenes; Xenopus laevis | 2002 |
Synthesis and biological evaluation of structurally highly modified analogues of the antimitotic natural product curacin A.
Topics: Antineoplastic Agents; Biopolymers; Blood Proteins; Cell Division; Cyclopropanes; Drug Screening Assays, Antitumor; Humans; Oximes; Protein Binding; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Thiophenes; Tubulin; Tumor Cells, Cultured | 2002 |
Antioxidative activity of heterocyclic compounds found in coffee volatiles produced by Maillard reaction.
Topics: Aldehydes; Antioxidants; Coffee; Furans; Heterocyclic Compounds; Maillard Reaction; Pyrazines; Pyrroles; Thiazoles; Thiophenes; Volatilization | 2002 |
Matrix metalloproteinases are differentially expressed in adipose tissue during obesity and modulate adipocyte differentiation.
Topics: Adipocytes; Animals; Blood Vessels; CCAAT-Enhancer-Binding Protein-beta; Cell Differentiation; Diet; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Hypoglycemic Agents; Male; Matrix Metalloproteinase 12; Matrix Metalloproteinase 2; Matrix Metalloproteinase 3; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Matrix Metalloproteinases, Membrane-Associated; Matrix Metalloproteinases, Secreted; Metalloendopeptidases; Mice; Mice, Inbred AKR; Mice, Inbred C57BL; Mice, Obese; Mitosis; Obesity; Phenylalanine; Protease Inhibitors; RNA, Messenger; Rosiglitazone; Stromal Cells; Thiazoles; Thiazolidinediones; Thiophenes; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-3 | 2003 |
Synthesis and antiprotozoal activity of naphthofuranquinones and naphthothiophenequinones containing a fused thiazole ring.
Topics: Animals; Antiprotozoal Agents; Furans; Humans; Leishmania donovani; Molecular Structure; Myeloid Cells; Naphthoquinones; Parasitic Sensitivity Tests; Structure-Activity Relationship; Thiazoles; Thiophenes; Toxoplasma | 2003 |
Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition.
Topics: Animals; Brain; Cell Line; Cognition; Female; GABA Agonists; Hippocampus; Humans; In Vitro Techniques; Ligands; Male; Maze Learning; Memory; Mice; Nootropic Agents; Oocytes; Patch-Clamp Techniques; Protein Subunits; Radioligand Assay; Rats; Receptors, GABA-A; Seizures; Structure-Activity Relationship; Thiazoles; Thiophenes; Xenopus laevis | 2003 |
[CHEMOTHERAPY OF EXPERIMENTAL PULMONARY STRONGYLOSIS IN GUINEA PIGS].
Topics: Animals; Anthelmintics; Diethylcarbamazine; Guinea Pigs; Heterocyclic Compounds; Lung Diseases; Lung Diseases, Parasitic; Nematode Infections; Pharmacology; Phenazines; Piperazines; Research; Strongyloidiasis; Thiazoles; Thiophenes | 1963 |
THE EFFECTS OF PHENYLALANINE AND TYROSINE ANALOGS ON THE SYNTHESIS AND ACTIVITY OF 3-DEOXY-D-ARABINO-HEPTULOSONIC ACID 7-PHOSPHATE SYNTHETASES.
Topics: Carbohydrate Metabolism; Enzyme Inhibitors; Escherichia coli; Ligases; Mutation; Naphthalenes; Pharmacology; Phenylalanine; Phosphates; Pyridines; Research; Thiazoles; Thiophenes; Tyrosine | 1964 |
Infrared study on solvent-solute interactions of 2-acetylthiophene in binary mixtures.
Topics: Alcohols; Carbon; Chemical Phenomena; Chemistry; Oxygen; Solutions; Solvents; Spectrophotometry, Infrared; Thiazoles; Thiophenes; Water | 2004 |
A novel series of potent and selective small molecule inhibitors of the complement component C1s.
Topics: Binding Sites; Complement C1; Complement Inactivator Proteins; Complement Pathway, Classical; Humans; Myocardial Ischemia; Pyrazoles; Serine Endopeptidases; Serine Proteinase Inhibitors; Structure-Activity Relationship; Thiazoles; Thiophenes | 2004 |
Syntheses and properties of donor-acceptor-type 2,5-diarylthiophene and 2,5-diarylthiazole.
Topics: Catalysis; Fluorides; Molecular Structure; Palladium; Silver Compounds; Thiazoles; Thiophenes | 2004 |
Synthesis and structure-activity relationships of uracil derived human GnRH receptor antagonists: (R)-3-[2-(2-amino)phenethyl]-1-(2,6-difluorobenzyl)-6-methyluracils containing a substituted thiophene or thiazole at C-5.
Topics: Humans; Receptors, LHRH; Structure-Activity Relationship; Thiazoles; Thiophenes; Uracil | 2004 |
Liquid chromatographic determination of novel aminithiazolecarboxamide fungicide residues in soil and crops using online solid-phase extraction.
Topics: Calibration; Chromatography, High Pressure Liquid; Crops, Agricultural; Fungicides, Industrial; Soil Pollutants; Thiazoles; Thiophenes | 2004 |
Synthesis and fungicidal activity of ethaboxam against Oomycetes.
Topics: Fungicides, Industrial; Inhibitory Concentration 50; Microbial Sensitivity Tests; Oomycetes; Phytophthora; Plant Diseases; Pythium; Thiazoles; Thiophenes | 2004 |
Identification of small molecule chemical inhibitors of the collagen-specific chaperone Hsp47.
Topics: Collagen; Databases, Factual; Heat-Shock Proteins; Molecular Chaperones; Nephelometry and Turbidimetry; Pyridazines; Serpins; Sulfides; Thiazoles; Thiophenes | 2005 |
In vivo effects of the fungicide ethaboxam on microtubule integrity in Phytophthora infestans.
Topics: Animals; Cell Line; Fungicides, Industrial; Hyphae; Mice; Microtubules; Phytophthora; Thiazoles; Thiophenes | 2005 |
Evaluation of potential molecular markers for urban stormwater runoff.
Topics: Benzothiazoles; Chrysenes; Cities; Environmental Monitoring; Geologic Sediments; Polycyclic Aromatic Hydrocarbons; Rain; Seasons; South Carolina; Sulfur Compounds; Thiazoles; Thiophenes; Time Factors; Water; Water Pollutants, Chemical; Water Supply | 2004 |
Allosteric modulators affect the internalization of human adenosine A1 receptors.
Topics: Adenosine; Allosteric Regulation; Animals; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Endocytosis; Humans; Luminescent Proteins; Microscopy, Confocal; Radioligand Assay; Receptor, Adenosine A1; Recombinant Fusion Proteins; Thiadiazoles; Thiazoles; Thiophenes; Transfection; Tritium; Xanthines | 2005 |
Functionalized magnesium organometallics as versatile intermediates for the synthesis of polyfunctional heterocycles.
Topics: Antipyrine; Combinatorial Chemistry Techniques; Esters; Furans; Heterocyclic Compounds; Imidazoles; Imines; Iodides; Magnesium; Models, Chemical; Nitriles; Organometallic Compounds; Pyridines; Pyrroles; Quinolines; Thiazoles; Thiophenes; Uracil | 2006 |
Determination of the enantiomeric composition of a new insulin sensitizer in plasma samples from non-clinical and clinical investigations using chiral HPLC with electrospray tandem mass spectrometric detection.
Topics: Animals; Chromatography, High Pressure Liquid; Humans; Hypoglycemic Agents; Rats; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism; Thiazoles; Thiazolidinediones; Thiophenes | 2006 |
Synthesis, spectroscopic, thermal and antimicrobial studies of some novel metal complexes of Schiff base derived from [N1-(4-methoxy-1,2,5-thiadiazol-3-yl)sulfanilamide] and 2-thiophene carboxaldehyde.
Topics: Aldehydes; Bacteria; Electric Conductivity; Electrons; Kinetics; Ligands; Magnetic Resonance Spectroscopy; Magnetics; Metals; Microbial Sensitivity Tests; Schiff Bases; Spectrophotometry, Infrared; Sulfanilamide; Sulfanilamides; Temperature; Thermodynamics; Thermogravimetry; Thiazoles; Thiophenes | 2007 |
Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization.
Topics: Acetylene; Animals; Aryl Hydrocarbon Hydroxylases; Crystallography, X-Ray; Cytochrome P-450 CYP2A6; Enzyme Inhibitors; Furans; Humans; Imidazoles; In Vitro Techniques; Isoxazoles; Mice; Microsomes, Liver; Mixed Function Oxygenases; Models, Molecular; Molecular Structure; Nicotine; Pyrazoles; Pyridines; Structure-Activity Relationship; Thiazoles; Thiophenes; Time Factors | 2006 |
Insights into the mechanism of the site-selective sequential palladium-catalyzed cross-coupling reactions of dibromothiophenes/dibromothiazoles and arylboronic acids. Synthesis of PPARbeta/delta agonists.
Topics: Catalysis; HeLa Cells; Humans; Models, Molecular; Molecular Structure; Palladium; PPAR delta; PPAR-beta; Thiazoles; Thiophenes | 2006 |
Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening.
Topics: Adult; Arachidonate 5-Lipoxygenase; Biological Products; Cell-Free System; Databases, Factual; Humans; In Vitro Techniques; Lipoxygenase Inhibitors; Models, Molecular; Neutrophils; Pyridines; Structure-Activity Relationship; Tetrahydronaphthalenes; Thiazoles; Thiophenes | 2007 |
Novel non-steroidal inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Benzamides; Benzimidazoles; Binding Sites; Cells, Cultured; Drug Evaluation; Enzyme Inhibitors; Fluorenes; Humans; Models, Biological; Models, Molecular; Sulfonamides; Thiazoles; Thiophenes | 2007 |
Synthesis and SAR of selective benzothiophene, benzofuran, and indole-based peroxisome proliferator-activated receptor delta agonists.
Topics: Animals; Benzofurans; Chemistry, Pharmaceutical; Drug Design; Drug Evaluation, Preclinical; Humans; Indoles; Inhibitory Concentration 50; Ligands; Models, Chemical; PPAR delta; Structure-Activity Relationship; Thiazoles; Thiophenes | 2007 |
MAO-A-induced mitogenic signaling is mediated by reactive oxygen species, MMP-2, and the sphingolipid pathway.
Topics: Animals; Biogenic Amines; Blood Vessels; Butylated Hydroxytoluene; Cell Proliferation; Free Radical Scavengers; Hydrogen Peroxide; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Mice; Mice, Mutant Strains; Mitogens; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Myocytes, Smooth Muscle; Oxidation-Reduction; Pargyline; Phenylalanine; Rabbits; Reactive Oxygen Species; RNA, Small Interfering; Serotonin; Signal Transduction; Sphingolipids; Thiazoles; Thiophenes; Tyramine | 2007 |
Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore.
Topics: Aminopeptidases; Angiogenesis Inhibitors; Animals; Aorta, Thoracic; Capillaries; Cell Proliferation; Crystallography, X-Ray; Endothelial Cells; Endothelium, Vascular; Furans; In Vitro Techniques; Male; Metalloendopeptidases; Models, Molecular; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiazoles; Thiophenes; Triazoles | 2007 |
Identification and characterization of a selective peroxisome proliferator-activated receptor beta/delta (NR1C2) antagonist.
Topics: Cells, Cultured; Chromatin Immunoprecipitation; Dose-Response Relationship, Drug; Fatty Acids; Fluorescence Resonance Energy Transfer; Gene Expression Regulation; Humans; Ligands; Molecular Structure; Muscle, Skeletal; Oxidation-Reduction; PPAR delta; PPAR-beta; Sulfones; Thiazoles; Thiophenes | 2008 |
Aryl triflates: useful coupling partners for the direct arylation of heteroaryl derivatives via Pd-catalyzed C-H activation-functionalization.
Topics: Catalysis; Furans; Mesylates; Oxazoles; Palladium; Thiazoles; Thiophenes | 2008 |
Metabolite generation via microbial biotransformations with Actinomycetes: rapid screening for active strains and biosynthesis of important human metabolites of two development-stage compounds, 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-
Topics: Actinobacteria; Animals; Biotransformation; Dasatinib; Drugs, Investigational; Humans; Microbial Sensitivity Tests; Microsomes, Liver; Pyrimidines; Rats; Spiro Compounds; Swine; Thiazoles; Thiophenes | 2008 |
Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymerase.
Topics: Antiviral Agents; Chemistry, Pharmaceutical; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Genotype; Humans; Inhibitory Concentration 50; Models, Chemical; Molecular Conformation; RNA, Viral; Structure-Activity Relationship; Thiazoles; Thiophenes; Viral Nonstructural Proteins | 2008 |
AKR-501 (YM477) in combination with thrombopoietin enhances human megakaryocytopoiesis.
Topics: Antigens, CD; Antigens, CD34; Blood Platelets; Cells, Cultured; Colony-Forming Units Assay; Flow Cytometry; Humans; Piperidines; Receptors, Thrombopoietin; Thiazoles; Thiophenes; Thrombocytopenia; Thrombopoiesis; Thrombopoietin | 2008 |
N-(thiazol-2-yl)-2-thiophene carboxamide derivatives as Abl inhibitors identified by a pharmacophore-based database screening of commercially available compounds.
Topics: Amides; Computer-Aided Design; Drug Design; Ligands; Models, Molecular; Molecular Structure; Proto-Oncogene Proteins c-abl; Small Molecule Libraries; Structure-Activity Relationship; Thiazoles; Thiophenes | 2008 |
AKR-501 (YM477) a novel orally-active thrombopoietin receptor agonist.
Topics: Administration, Oral; Animals; Antigens, CD34; Blood Platelets; Cell Differentiation; Fetal Blood; Hematopoiesis; Humans; Liver; Megakaryocytes; Mice; Mice, Inbred NOD; Mice, SCID; Pan troglodytes; Platelet Count; Ploidies; Polyploidy; Receptors, Thrombopoietin; Recombinant Proteins; Stem Cell Transplantation; Thiazoles; Thiophenes; Thrombopoietin | 2009 |
Design of chimeric histone deacetylase- and tyrosine kinase-inhibitors: a series of imatinib hybrides as potent inhibitors of wild-type and mutant BCR-ABL, PDGF-Rbeta, and histone deacetylases.
Topics: Acetylation; Benzamides; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Fusion Proteins, bcr-abl; Histone Deacetylase Inhibitors; Histones; Humans; Imatinib Mesylate; Models, Molecular; Mutation; Phthalic Acids; Piperazines; Protein-Tyrosine Kinases; Pyrimidines; Receptor, Platelet-Derived Growth Factor beta; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Thiophenes | 2009 |
Synthesis and antibacterial activity of some new thiazole and thiophene derivatives.
Topics: Anti-Bacterial Agents; Bacillus; Escherichia coli; Microbial Sensitivity Tests; Molecular Structure; Structure-Activity Relationship; Thiazoles; Thiophenes | 2009 |
Characterization of two classes of small molecule inhibitors of Arp2/3 complex.
Topics: Actin Cytoskeleton; Actin-Related Protein 2; Actin-Related Protein 2-3 Complex; Actin-Related Protein 3; Actins; Animals; Biopolymers; Cattle; Cell Line; Crystallography, X-Ray; Humans; Hydrophobic and Hydrophilic Interactions; Indoles; Listeria; Models, Molecular; Monocytes; Protein Conformation; Schizosaccharomyces; Thiazoles; Thiophenes | 2009 |
Switching to duloxetine remits ziprasidone - associated urinary incontinence and improves neuropsychiatric behavior in dementia: possible relationship of incontinence to 5HT2 receptor blockade.
Topics: Aged, 80 and over; Alzheimer Disease; Dementia, Vascular; Duloxetine Hydrochloride; Humans; Male; Parkinsonian Disorders; Piperazines; Receptors, Serotonin, 5-HT2; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Thiazoles; Thiophenes; Urinary Incontinence | 2009 |
New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitory activity and selectivity.
Topics: 17-Hydroxysteroid Dehydrogenases; Administration, Oral; Animals; Benzene Derivatives; Biphenyl Compounds; Crystallography, X-Ray; Cytochrome P-450 Enzyme Inhibitors; Estradiol Dehydrogenases; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Humans; Isoenzymes; Liver; Male; Models, Molecular; Phenols; Placenta; Pregnancy; Protein Binding; Rats; Rats, Wistar; Stereoisomerism; Structure-Activity Relationship; Terphenyl Compounds; Thiazoles; Thiophenes | 2009 |
Endothelium-dependent vasodilator effects of peroxisome proliferator-activated receptor beta agonists via the phosphatidyl-inositol-3 kinase-Akt pathway.
Topics: Anilides; Animals; Aorta; Chromones; Endothelium, Vascular; Enzyme Inhibitors; Humans; Male; Morpholines; Nitric Oxide; Nitric Oxide Synthase Type III; Phenoxyacetates; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; PPAR-beta; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Signal Transduction; Sulfones; Thiazoles; Thiophenes; Umbilical Veins; Vasodilation | 2010 |
Evidence for the role of peroxisome proliferator-activated receptor-beta/delta in the development of spinal cord injury.
Topics: Animals; Apoptosis; Cytokines; Enzyme Induction; Fas Ligand Protein; Male; Mice; Neutrophil Infiltration; Nitric Oxide Synthase; Peroxidase; PPAR delta; PPAR-beta; Spinal Cord Injuries; Sulfones; Thiazoles; Thiophenes; Tumor Necrosis Factor-alpha; Tyrosine | 2010 |
Activation of peroxisome proliferator-activated receptor-{delta} by GW501516 prevents fatty acid-induced nuclear factor-{kappa}B activation and insulin resistance in skeletal muscle cells.
Topics: Analysis of Variance; Animals; Blotting, Western; Carnitine O-Palmitoyltransferase; Cell Line; Cell Nucleus; Electrophoretic Mobility Shift Assay; Epoxy Compounds; Fatty Acids; Humans; Insulin Resistance; Interleukin-6; Mice; Muscle, Skeletal; NF-kappa B; PPAR delta; Protein Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfones; Thiazoles; Thiophenes | 2010 |
Luminescence modulation of ordered upconversion nanopatterns by a photochromic diarylethene: rewritable optical storage with nondestructive readout.
Topics: Luminescence; Nanoparticles; Optics and Photonics; Photochemistry; Thiazoles; Thiophenes | 2010 |
Synthesis and study of the use of heterocyclic thiosemicarbazones as signaling scaffolding for the recognition of anions.
Topics: Anions; Bridged-Ring Compounds; Furans; Molecular Structure; Thiazoles; Thiophenes; Thiosemicarbazones | 2010 |
Tandem 1,5-hydride shift/1,5-S,N-cyclization with ethylene extrusion of 1,3-oxathiolane-substituted ketenimines and carbodiimides. An experimental and computational study.
Topics: Carbodiimides; Cyclization; Ethylenes; Heterocyclic Compounds; Hot Temperature; Imines; Ketones; Models, Chemical; Thiazoles; Thiophenes | 2010 |
Protective role of peroxisome proliferator-activated receptor-β/δ in septic shock.
Topics: Animals; Disease Models, Animal; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Nitric Oxide Synthase Type II; Phosphorylation; PPAR delta; PPAR-beta; Proto-Oncogene Proteins c-akt; Shock, Septic; Signal Transduction; Sulfones; Thiazoles; Thiophenes | 2010 |
New two-photon-absorbing probe with efficient superfluorescent properties.
Topics: Absorption; Endosomes; Fluorescence Polarization; Fluorescent Dyes; HCT116 Cells; Humans; Lasers; Lysosomes; Microscopy, Fluorescence; Photons; Solvents; Thiazoles; Thiophenes | 2010 |
Pharmacological profile of AS1670542, a novel orally-active human thrombopoietin receptor agonist.
Topics: Administration, Oral; Amino Acid Sequence; Animals; Antigens, CD34; Benzoates; Cell Line; Cell Membrane; Dogs; Female; Histidine; Humans; Hydrazines; Liver; Mice; Molecular Sequence Data; Platelet Count; Protein Structure, Tertiary; Pyrazoles; Rats; Receptors, Thrombopoietin; Species Specificity; Stem Cell Transplantation; Thiazoles; Thiophenes | 2011 |
Bicyclic substituted hydroxyphenylmethanones as novel inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) for the treatment of estrogen-dependent diseases.
Topics: Cell Line, Tumor; Drug Design; Drug Stability; Estradiol Dehydrogenases; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Humans; In Vitro Techniques; Microsomes, Liver; Phenols; Placenta; Pregnancy; Structure-Activity Relationship; Thiazoles; Thiophenes | 2010 |
Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK.
Topics: Animals; Drug Design; Humans; JNK Mitogen-Activated Protein Kinases; Mice; Microsomes, Liver; Mitogen-Activated Protein Kinase 10; Mitogen-Activated Protein Kinase 8; Protein Kinase Inhibitors; Quinolines; Structure-Activity Relationship; Thiazoles; Thiophenes | 2010 |
Anti-breast cancer activity of some novel 1,2-dihydropyridine, thiophene and thiazole derivatives.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Dihydropyridines; Humans; Inhibitory Concentration 50; Structure-Activity Relationship; Thiazoles; Thiophenes | 2011 |
Novel synthesis of hydrazide-hydrazone derivatives and their utilization in the synthesis of coumarin, pyridine, thiazole and thiophene derivatives with antitumor activity.
Topics: Antineoplastic Agents; Azides; Cell Division; Cell Line, Tumor; Coumarins; Drug Screening Assays, Antitumor; Humans; Hydrazones; Magnetic Resonance Spectroscopy; Pyridines; Thiazoles; Thiophenes | 2010 |
Factor Xa and thrombin as targets for new oral anticoagulants.
Topics: Acute Coronary Syndrome; Administration, Oral; Anticoagulants; Atrial Fibrillation; Benzimidazoles; Clinical Trials as Topic; Dabigatran; Drug Discovery; Factor Xa Inhibitors; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Stroke; Thiazoles; Thiophenes; Thrombin; Venous Thromboembolism; Vitamin K | 2011 |
A poly(ε-caprolactone) device for sustained release of an anti-glaucoma drug.
Topics: Animals; Antihypertensive Agents; Biocompatible Materials; Calorimetry, Differential Scanning; Cornea; Delayed-Action Preparations; Diffusion; Drug Delivery Systems; Glaucoma; Polyesters; Polymers; Porosity; Rabbits; Regression Analysis; Sulfonamides; Tetrazolium Salts; Thiazoles; Thiophenes; X-Ray Diffraction | 2011 |
Oxidative biaryl coupling of thiophenes and thiazoles with arylboronic acids through palladium catalysis: otherwise difficult C4-selective C-H arylation enabled by boronic acids.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Boronic Acids; Carbon; Catalysis; Cyclic N-Oxides; Humans; Hydrogen; Oxidation-Reduction; Palladium; Protease Inhibitors; Stereoisomerism; Thiazoles; Thiophenes | 2011 |
An in-vitro evaluation of the polo-like kinase inhibitor GW843682X against paediatric malignancies.
Topics: Antineoplastic Agents; ATP-Binding Cassette Transporters; Benzimidazoles; Blotting, Western; Camptothecin; Caspases; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Child; Coloring Agents; Enzyme Activation; Enzyme Inhibitors; Humans; Neoplasms; Polo-Like Kinase 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; RNA, Messenger; Tetrazolium Salts; Thiazoles; Thiophenes; Topoisomerase I Inhibitors | 2011 |
[New anticoagulants in the prevention and treatment of venous thromboembolism].
Topics: Administration, Oral; Anticoagulants; Antithrombins; Benzimidazoles; beta-Alanine; Clinical Trials as Topic; Dabigatran; Drug Costs; Drugs, Investigational; Factor Xa Inhibitors; Humans; Hungary; Morpholines; Oligosaccharides; Pulmonary Embolism; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Thiazoles; Thiophenes; Thrombin; Venous Thromboembolism | 2011 |
Design and synthesis of novel antimicrobial acyclic and heterocyclic dyes and their precursors for dyeing and/or textile finishing based on 2-N-acylamino-4,5,6,7-tetrahydro-benzo[b]thiophene systems.
Topics: Acetamides; Ampicillin; Anti-Bacterial Agents; Antifungal Agents; Bacillus cereus; Bacillus subtilis; Candida albicans; Coloring Agents; Drug Design; Escherichia coli; Heterocyclic Compounds, 2-Ring; Materials Testing; Microbial Sensitivity Tests; Nitriles; Prodrugs; Pyrazoles; Pyrimidines; Textile Industry; Textiles; Thiazoles; Thiophenes | 2011 |
The new oral anticoagulants.
Topics: Anticoagulants; Benzimidazoles; Clinical Trials, Phase III as Topic; Dabigatran; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Thiazoles; Thiophenes | 2011 |
Synthesis and antioxidant and antitumor activity of novel pyridine, chromene, thiophene and thiazole derivatives.
Topics: Animals; Antineoplastic Agents; Antioxidants; Benzopyrans; DNA Damage; Pyridines; Rats; Structure-Activity Relationship; Thiazoles; Thiophenes | 2012 |
Determination of different putative allosteric binding pockets at the lutropin receptor by using diverse drug-like low molecular weight ligands.
Topics: Allosteric Site; Animals; Benzamides; Binding Sites; Carbamates; CHO Cells; Cricetinae; Ligands; Models, Molecular; Protein Binding; Protein Structure, Secondary; Pyrimidines; Receptors, LH; Terphenyl Compounds; Thiazoles; Thiophenes | 2012 |
Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P₃-sparing S1P₁ agonists.
Topics: Animals; Haplorhini; Humans; Pyridines; Rats; Receptors, Lysosphingolipid; Structure-Activity Relationship; Thiazoles; Thiophenes | 2012 |
5-HT(6) receptor agonists and antagonists enhance learning and memory in a conditioned emotion response paradigm by modulation of cholinergic and glutamatergic mechanisms.
Topics: Animals; Conditioning, Psychological; Dizocilpine Maleate; Electric Stimulation; Emotions; Indoles; Learning; Male; Pyridines; Rats; Receptors, Serotonin; Scopolamine; Serotonin Antagonists; Serotonin Receptor Agonists; Sulfonamides; Thiazoles; Thiophenes | 2012 |
Discovery and optimization of a series of 2-aryl-4-amino-5-(3',4',5'-trimethoxybenzoyl)thiazoles as novel anticancer agents.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Endothelial Cells; Enzyme Activation; Humans; Hydroxybenzoates; Mice; Mice, Nude; Mitochondria; Models, Molecular; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Structure-Activity Relationship; Thiazoles; Thiophenes; Transplantation, Heterologous; Tubulin Modulators | 2012 |
A novel and expedient approach to new thiazoles, thiazolo[3,2-a]pyridines, dihydrothiophenes, and hydrazones incorporating thieno[2,3-b]thiophene moiety.
Topics: Drug Discovery; Gas Chromatography-Mass Spectrometry; Heterocyclic Compounds; Hydrazones; Magnetic Resonance Spectroscopy; Spectrophotometry, Ultraviolet; Thiazoles; Thiophenes | 2012 |
Forced mitotic entry of S-phase cells as a therapeutic strategy induced by inhibition of WEE1.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Cycle Proteins; Cell Line; Cell Line, Tumor; Checkpoint Kinase 1; Cyclins; Deoxycytidine; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Female; Gemcitabine; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, SCID; Mitosis; Nuclear Proteins; Polycomb Repressive Complex 2; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Pyrimidinones; Quinolines; S Phase; Thiazoles; Thiophenes; Transcription Factors; Tumor Burden; Tumor Suppressor Protein p53; Urea; Xenograft Model Antitumor Assays | 2012 |
Selective GABA(A) α5 positive allosteric modulators improve cognitive function in aged rats with memory impairment.
Topics: Aging; Allosteric Regulation; Animals; Carboxylic Acids; Cognition; Cognitive Dysfunction; GABA-A Receptor Agonists; Hippocampus; Infusions, Intraventricular; Injections, Intraperitoneal; Male; Memory; Memory Disorders; Molecular Targeted Therapy; Neurons; Nootropic Agents; Pyridazines; Rats; Rats, Long-Evans; Receptors, GABA-A; Specific Pathogen-Free Organisms; Synaptic Transmission; Thiazoles; Thiophenes | 2013 |
Antitumor activity of novel pyridine, thiophene and thiazole derivatives.
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Death; Dose-Response Relationship, Drug; Doxorubicin; Female; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Molecular Structure; Pyridines; Spectrophotometry, Infrared; Thiazoles; Thiophenes | 2012 |
Topical administration of the pan-Src kinase inhibitors, dasatinib and LCB 03-0110, prevents allergic contact dermatitis in mice.
Topics: Adjuvants, Immunologic; Administration, Cutaneous; Aminopyridines; Animals; Anti-Inflammatory Agents; Atrophy; Dasatinib; Dermatitis, Allergic Contact; Drug Evaluation; Female; Mice; Mice, Hairless; Mice, Inbred BALB C; Oxazolone; Protein Kinase Inhibitors; Pyrimidines; Skin; Thiazoles; Thiophenes | 2013 |
Heterocyclizations of pregnenolone: novel synthesis of thiosemicarbazone, thiophene, thiazole, thieno[2,3-b]pyridine derivatives and their cytotoxicity evaluations.
Topics: Cell Line, Tumor; Cyclization; Drug Screening Assays, Antitumor; Humans; Pregnenolone; Pyridines; Thiazoles; Thiophenes; Thiosemicarbazones | 2012 |
Reaction of pregnenolone with cyanoacetylhydrazine: novel synthesis of hydrazide-hydrazone, pyrazole, pyridine, thiazole, thiophene derivatives and their cytotoxicity evaluations.
Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Hydrazines; Hydrazones; Nitriles; Pregnenolone; Pyrazoles; Pyridines; Thiazoles; Thiophenes | 2012 |
A case of severe hyponatremia induced by duloxetine and ziprasidone.
Topics: Antidepressive Agents; Antipsychotic Agents; Creatine Kinase; Depressive Disorder, Major; Duloxetine Hydrochloride; Female; Humans; Hyponatremia; Middle Aged; Piperazines; Thiazoles; Thiophenes | 2012 |
[Introduction].
Topics: Acenocoumarol; Anticoagulants; Benzamides; Benzimidazoles; beta-Alanine; Dabigatran; Heparin; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Stroke; Thiazoles; Thiophenes; Thromboembolism; Thrombosis; Warfarin | 2012 |
The beta 1 tubulin R307H single nucleotide polymorphism is associated with treatment failures in immune thrombocytopenia (ITP).
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alleles; Antibodies, Monoclonal, Murine-Derived; Benzoates; Biomarkers; Child; Child, Preschool; Female; Gene Frequency; Genotype; Humans; Hydrazines; Immunologic Factors; Infant; Male; Middle Aged; Phenotype; Platelet Count; Polymorphism, Single Nucleotide; Purpura, Thrombocytopenic, Idiopathic; Pyrazoles; Receptors, Fc; Receptors, Thrombopoietin; Recombinant Fusion Proteins; Retrospective Studies; Rituximab; Thiazoles; Thiophenes; Thrombopoiesis; Thrombopoietin; Treatment Failure; Tubulin | 2013 |
A peroxisome proliferator-activated receptor-δ agonist provides neuroprotection in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Cell Count; Cells, Cultured; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Female; Glial Fibrillary Acidic Protein; Humans; Macrophage-1 Antigen; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroprotective Agents; Parkinsonian Disorders; PPAR delta; Rats; Sulfones; Thiazoles; Thiophenes; Tyrosine 3-Monooxygenase | 2013 |
Novel ferrocenyl-containing N-acetyl-2-pyrazolines inhibit in vitro angiogenesis and human lung cancer growth by interfering with F-actin stress fiber polimeryzation.
Topics: Actins; Angiogenesis Inhibitors; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Collagen; Colony-Forming Units Assay; Dose-Response Relationship, Drug; Drug Combinations; Ferrous Compounds; Human Umbilical Vein Endothelial Cells; Humans; Indoles; Laminin; Lung Neoplasms; Neovascularization, Pathologic; Polymerization; Proteoglycans; Pyrazoles; Tetrazolium Salts; Thiazoles; Thiophenes | 2013 |
Sphingosine 1-phosphate (S1P) receptor agonists mediate pro-fibrotic responses in normal human lung fibroblasts via S1P2 and S1P3 receptors and Smad-independent signaling.
Topics: Actins; Animals; CHO Cells; Cricetinae; Cricetulus; Down-Regulation; Extracellular Matrix; Humans; Lung; Lysophospholipids; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myofibroblasts; Organophosphates; Oxadiazoles; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pulmonary Fibrosis; Receptors, Lysosphingolipid; Signal Transduction; Smad2 Protein; Smad3 Protein; Sphingosine; Thiazoles; Thiophenes; Transforming Growth Factor beta1 | 2013 |
Peroxisome proliferator-activated receptor-β/δ regulates angiogenic cell behaviors and oxygen-induced retinopathy.
Topics: Angiogenesis Inhibitors; Animals; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Humans; Oxygen; PPAR delta; PPAR-beta; Rats; Retinal Diseases; Retinal Neovascularization; Retinal Vessels; Sulfones; Thiazoles; Thiophenes | 2013 |
Synthesis of isomeric isothiazolo[4',3':4,5]- and isothiazolo[4',5':4,5]thieno[3,2-b]pyrano[2,3-d]pyridines by combination of domino reactions.
Topics: Combinatorial Chemistry Techniques; Models, Molecular; Molecular Structure; Pyrans; Pyridines; Stereoisomerism; Sulfhydryl Compounds; Thiazoles; Thiophenes | 2013 |
Synthesis and antimicrobial activity of some novel hydrazide, benzochromenone, dihydropyridine, pyrrole, thiazole and thiophene derivatives.
Topics: Anti-Bacterial Agents; Antifungal Agents; Benzopyrans; Candida albicans; Dihydropyridines; Dose-Response Relationship, Drug; Escherichia coli; Hydrazones; Microbial Sensitivity Tests; Molecular Structure; Pyrroles; Staphylococcus aureus; Structure-Activity Relationship; Thiazoles; Thiophenes | 2013 |
Development and validation of method for heterocyclic compounds in wine: optimization of HS-SPME conditions applying a response surface methodology.
Topics: Factor Analysis, Statistical; Furans; Gas Chromatography-Mass Spectrometry; Humans; Hydrogen-Ion Concentration; Maillard Reaction; Pyrazines; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Microextraction; Temperature; Thiazoles; Thiophenes; Wine | 2013 |
Activation of PPARβ/δ protects pancreatic β cells from palmitate-induced apoptosis by upregulating the expression of GLP-1 receptor.
Topics: Animals; Apoptosis; Cells, Cultured; Glucagon-Like Peptide-1 Receptor; Insulin; Insulin Secretion; Insulin-Secreting Cells; Male; Palmitates; PPAR delta; PPAR-beta; Rats; Rats, Wistar; Receptors, Glucagon; RNA Interference; RNA, Small Interfering; Signal Transduction; Sulfones; Thiazoles; Thiophenes; Up-Regulation | 2014 |
Thiophene-thiazolothiazole copolymers: significant impact of side chain composition on backbone orientation and solar cell performances.
Topics: Polymers; Polystyrenes; Solar Energy; Thiazoles; Thiophenes; Tin Compounds; Transistors, Electronic | 2014 |
New oral anticoagulants for acute venous thromboembolism.
Topics: Acute Disease; Anticoagulants; Benzimidazoles; Dabigatran; Drug Approval; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Thiazoles; Thiophenes; Treatment Outcome; Venous Thromboembolism | 2014 |
Synthesis of 2,5-diaryl-substituted thiophenes as helical mimetics: towards the modulation of islet amyloid polypeptide (IAPP) amyloid fibril formation and cytotoxicity.
Topics: Amyloid; Benzothiazoles; Insulin-Secreting Cells; Islet Amyloid Polypeptide; Molecular Structure; Thiazoles; Thiophenes | 2014 |
Comparison of the phase III clinical trial designs of novel oral anticoagulants versus warfarin for the treatment of nonvalvular atrial fibrillation: implications for clinical practice.
Topics: Administration, Oral; Anticoagulants; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Clinical Trials, Phase III as Topic; Dabigatran; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Research Design; Rivaroxaban; Thiazoles; Thiophenes; Vitamin K; Warfarin | 2014 |
Efficacy and safety of edoxaban in comparison with dabigatran, rivaroxaban and apixaban for stroke prevention in atrial fibrillation. An indirect comparison analysis.
Topics: Administration, Oral; Aged; Anticoagulants; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Clinical Trials, Phase III as Topic; Dabigatran; Female; Hemorrhage; Humans; Male; Middle Aged; Morpholines; Myocardial Infarction; Precision Medicine; Pyrazoles; Pyridines; Pyridones; Randomized Controlled Trials as Topic; Rivaroxaban; Stroke; Survival Analysis; Thiazoles; Thiophenes; Treatment Outcome | 2014 |
Palladium-catalyzed oxidative C-H/C-H cross-coupling of benzothiazoles with thiophenes and thiazoles.
Topics: Benzothiazoles; Catalysis; Molecular Structure; Oxidation-Reduction; Palladium; Thiazoles; Thiophenes | 2014 |
Protective role of peroxisome proliferator-activated receptor-β/δ against pulmonary oxygen toxicity mediated through changes in NOS expression levels.
Topics: Acute Lung Injury; Animals; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase; Oxygen; PPAR delta; PPAR-beta; Random Allocation; Rats; Rats, Sprague-Dawley; Sulfones; Thiazoles; Thiophenes; Up-Regulation | 2014 |
Measurement of the direct oral anticoagulants apixaban, dabigatran, edoxaban, and rivaroxaban in human plasma using turbulent flow liquid chromatography with high-resolution mass spectrometry.
Topics: Anticoagulants; Benzimidazoles; beta-Alanine; Chromatography, Liquid; Dabigatran; Humans; Mass Spectrometry; Molecular Structure; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Thiazoles; Thiophenes | 2014 |
Perioperative management of patients on new oral anticoagulants.
Topics: Administration, Oral; Anticoagulants; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Biological Availability; Clinical Trials as Topic; Dabigatran; Drug Monitoring; Elective Surgical Procedures; Emergencies; Half-Life; Hemorrhage; Humans; Medication Adherence; Morpholines; Preoperative Care; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Stroke; Thiazoles; Thiophenes; Time Factors; Warfarin | 2014 |
Protective role of peroxisome proliferator-activated receptor β/δ in acute lung injury induced by prolonged hyperbaric hyperoxia in rats.
Topics: Acute Lung Injury; Animals; Antioxidants; Apoptosis; Cytokines; Disease Models, Animal; Hyperoxia; Lung; Male; MAP Kinase Signaling System; Neuroprotective Agents; NF-kappa B; PPAR delta; PPAR-beta; Pressure; Random Allocation; Rats, Sprague-Dawley; Respiratory System Agents; Sulfones; Thiazoles; Thiophenes; Time Factors | 2014 |
Direct oral anticoagulants--pharmacology, drug interactions, and side effects.
Topics: Administration, Oral; Anticoagulants; Benzimidazoles; beta-Alanine; Dabigatran; Drug Interactions; Drug Monitoring; Half-Life; Hemorrhage; Humans; Kidney; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Thiazoles; Thiophenes; Thromboembolism | 2014 |
Direct oral anticoagulants in atrial fibrillation.
Topics: Administration, Oral; Anticoagulants; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Dabigatran; Embolism; Hemorrhage; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Risk Factors; Rivaroxaban; Stroke; Thiazoles; Thiophenes; Warfarin | 2014 |
The effect of intermolecular interactions on the charge transport properties of thiazole/thiophene-based oligomers with trifluoromethylphenyl.
Topics: Energy Transfer; Hydrocarbons, Fluorinated; Hydrogen Bonding; Models, Molecular; Quantum Theory; Thiazoles; Thiophenes | 2014 |
The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1.
Topics: Anilides; Animals; Antineoplastic Agents, Phytogenic; Cytokines; Enzyme Activation; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Indans; Lysophospholipids; Male; Neuralgia; Organophosphonates; Oxadiazoles; Paclitaxel; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Thiazoles; Thiophenes | 2014 |
Medical management of acute ocular hypertension in a western screech owl (Megascops kennicottii).
Topics: Acute Disease; Animals; Bird Diseases; Carbonic Anhydrase Inhibitors; Diclofenac; Mannitol; Meloxicam; Ocular Hypertension; Strigiformes; Sulfonamides; Thiazines; Thiazoles; Thiophenes | 2014 |
Implication of novel thiazolo-thiophene derivative (MCD-KV-10) for management of asthma.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Cytokines; Guinea Pigs; Histamine; Lipoxygenases; Lung; Male; Mast Cells; Molecular Structure; Ovalbumin; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A2A; Receptor, Adenosine A3; Thiazoles; Thiophenes | 2015 |
The PPARβ/δ agonist GW0742 modulates signaling pathways associated with cardiac myocyte growth via a non-genomic redox mechanism.
Topics: Animals; Gene Expression Regulation; Male; MAP Kinase Signaling System; Myocytes, Cardiac; Oxidation-Reduction; Peroxisome Proliferator-Activated Receptors; PTEN Phosphohydrolase; Rats; Rats, Wistar; Reactive Oxygen Species; Sulfones; Thiazoles; Thiophenes; Vanadates | 2014 |
Edoxaban in the evolving scenario of non vitamin K antagonist oral anticoagulants imputed placebo analysis and multiple treatment comparisons.
Topics: Administration, Oral; Anticoagulants; Benzimidazoles; beta-Alanine; Clinical Trials as Topic; Dabigatran; Factor Xa Inhibitors; Humans; Meta-Analysis as Topic; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Stroke; Thiazoles; Thiophenes; Vitamin K; Warfarin | 2014 |
Use of ammonium formate in QuEChERS for high-throughput analysis of pesticides in food by fast, low-pressure gas chromatography and liquid chromatography tandem mass spectrometry.
Topics: Buffers; Chromatography, Gas; Chromatography, Liquid; Citrus; Drug Combinations; Edible Grain; Food Contamination; Formates; Fruit; Gas Chromatography-Mass Spectrometry; Insecticides; Lactuca; Limit of Detection; Macrolides; Malus; Organophosphorus Compounds; Pesticide Residues; Solid Phase Extraction; Sulfonylurea Compounds; Tandem Mass Spectrometry; Thiazoles; Thiophenes; Triazines; Triticum | 2014 |
Discovery of small-molecule inhibitors selectively targeting the DNA-binding domain of the human androgen receptor.
Topics: Androgen Receptor Antagonists; Animals; Antineoplastic Agents; Benzamides; Binding Sites; Cell Line, Tumor; Cell Survival; Computer Simulation; Databases, Chemical; DNA; Drug Resistance, Neoplasm; Humans; Imidazoles; Male; Molecular Conformation; Molecular Docking Simulation; Morpholines; Mutation; Nitriles; Phenylthiohydantoin; Prostate-Specific Antigen; Prostatic Neoplasms; Pyrvinium Compounds; Rats; Receptors, Androgen; Structure-Activity Relationship; Thiazoles; Thiophenes; Transcription, Genetic | 2014 |
Evaluation of medical costs associated with use of new oral anticoagulants compared with standard therapy among venous thromboembolism patients.
Topics: Anticoagulants; Benzimidazoles; beta-Alanine; Dabigatran; Fees, Pharmaceutical; Health Expenditures; Hemorrhage; Humans; Models, Econometric; Monte Carlo Method; Morpholines; Pyrazoles; Pyridines; Pyridones; Randomized Controlled Trials as Topic; Rivaroxaban; Thiazoles; Thiophenes; Venous Thromboembolism | 2014 |
Eligibility and preference of new oral anticoagulants in patients with atrial fibrillation: comparison between patients with versus without stroke.
Topics: Aged; Anticoagulants; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Dabigatran; Female; Humans; Male; Morpholines; Pyrazoles; Pyridines; Pyridones; Randomized Controlled Trials as Topic; Research Design; Rivaroxaban; Stroke; Thiazoles; Thiophenes; Warfarin | 2014 |
New oral anticoagulants in the management of venous thromboembolism: a major advance?
Topics: Anticoagulants; Benzimidazoles; beta-Alanine; Dabigatran; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Secondary Prevention; Thiazoles; Thiophenes; Venous Thromboembolism | 2014 |
Managing periprocedural thrombocytopenia in cirrhosis: aiming for a safety window.
Topics: Elective Surgical Procedures; Female; Humans; Liver Cirrhosis; Male; Receptors, Thrombopoietin; Thiazoles; Thiophenes; Thrombocytopenia | 2014 |
Novel anticoagulants eliminate the need for left atrial appendage exclusion devices.
Topics: Anticoagulants; Atrial Appendage; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Clinical Trials as Topic; Dabigatran; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Septal Occluder Device; Stroke; Thiazoles; Thiophenes; Unnecessary Procedures; Warfarin | 2014 |
3D-QSAR, molecular docking and molecular dynamics studies of a series of RORγt inhibitors.
Topics: Binding Sites; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Nuclear Receptor Subfamily 1, Group F, Member 3; Protein Binding; Protein Conformation; Quantitative Structure-Activity Relationship; Thiazoles; Thiophenes | 2015 |
Ligand-based pharmacophore modeling, atom-based 3D-QSAR and molecular docking studies on substituted thiazoles and thiophenes as polo-like kinase 1 (Plk1) inhibitors.
Topics: Antineoplastic Agents; Cell Cycle Proteins; Drug Design; Humans; Molecular Docking Simulation; Neoplasms; Polo-Like Kinase 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Quantitative Structure-Activity Relationship; Thiazoles; Thiophenes | 2014 |
Response to 'Re: Kakkos et al. Efficacy and safety of the new oral anticoagulants dabigatran, rivaroxaban, apixaban, and edoxaban in the treatment and secondary prevention of venous thromboembolism: a systematic review and meta-analysis of phase III trial
Topics: Anticoagulants; Benzimidazoles; beta-Alanine; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Secondary Prevention; Thiazoles; Thiophenes; Venous Thromboembolism | 2015 |
Re: 'Kakkos et al. Efficacy and safety of the new oral anticoagulants dabigatran, rivaroxaban, apixaban, and edoxaban in the treatment and secondary prevention of venous thromboembolism: a systematic review and meta-analysis of phase III trials'.
Topics: Anticoagulants; Benzimidazoles; beta-Alanine; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Secondary Prevention; Thiazoles; Thiophenes; Venous Thromboembolism | 2015 |
Novel thiazole-thiophene conjugates as adenosine receptor antagonists: synthesis, biological evaluation and docking studies.
Topics: Binding Sites; Catalytic Domain; Kinetics; Molecular Docking Simulation; Protein Binding; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A1; Receptor, Adenosine A3; Receptors, Adenosine A2; Receptors, Purinergic P1; Structure-Activity Relationship; Thiazoles; Thiophenes | 2015 |
[New oral anticoagulants in venous thromboembolism. General practice information on switching, monitoring, pausing].
Topics: Anticoagulants; Benzimidazoles; beta-Alanine; Dabigatran; Drug Monitoring; Drug Substitution; Half-Life; Hemorrhage; Humans; Kidney Function Tests; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Thiazoles; Thiophenes; Thromboembolism; Warfarin | 2015 |
Are new oral anticoagulant dosing recommendations optimal for all patients?
Topics: Administration, Oral; Anticoagulants; Antithrombins; Benzimidazoles; beta-Alanine; Dabigatran; Factor Xa Inhibitors; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Thiazoles; Thiophenes | 2015 |
Synthesis, anti-inflammatory and anti-ulcer evaluations of thiazole, thiophene, pyridine and pyran derivatives derived from androstenedione.
Topics: Androstenedione; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Drug Evaluation, Preclinical; Edema; Pyrans; Pyridines; Rats; Thiazoles; Thiophenes | 2015 |
Ligand-doped liquid crystal sensor system for detecting mercuric ion in aqueous solutions.
Topics: Ions; Ligands; Liquid Crystals; Magnetic Resonance Spectroscopy; Mercury; Solutions; Spectrophotometry, Ultraviolet; Thiazoles; Thiophenes; Water | 2015 |
Re: 'Re. Efficacy and Safety of the New Oral Anticoagulants Dabigatran, Rivaroxaban, Apixaban, and Edoxaban in the Treatment and Secondary Prevention of VTE: A Systematic Review and Meta-analysis of Phase III Trials'.
Topics: Anticoagulants; Benzimidazoles; beta-Alanine; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Secondary Prevention; Thiazoles; Thiophenes; Venous Thromboembolism | 2015 |
Cardiology patient page. Patient guide for taking the non-vitamin K antagonist oral anticoagulants for atrial fibrillation.
Topics: Administration, Oral; Anticoagulants; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Contraindications; Dabigatran; Drug Interactions; Drug Monitoring; Drug Substitution; Female; Hemorrhage; Humans; Kidney Diseases; Kidney Function Tests; Male; Morpholines; Pyrazoles; Pyridines; Pyridones; Risk Factors; Rivaroxaban; Stroke; Thiazoles; Thiophenes; Thrombophilia | 2015 |
Re: 'Efficacy and Safety of the New Oral Anticoagulants Dabigatran, Rivaroxaban, Apixaban, and Edoxaban in the Treatment and Secondary Prevention of Venous Thromboembolism: A Systematic Review and Meta-analysis of Phase III Trials'- Key Learning Points fo
Topics: Anticoagulants; Benzimidazoles; beta-Alanine; Humans; Morpholines; Pyrazoles; Pyridines; Pyridones; Secondary Prevention; Thiazoles; Thiophenes; Venous Thromboembolism | 2015 |
New selective inhibitors of calcium-activated chloride channels - T16A(inh) -A01, CaCC(inh) -A01 and MONNA - what do they inhibit?
Topics: Animals; Cell Line; Cerebral Arteries; Chloride Channels; Female; In Vitro Techniques; Male; Mesenteric Arteries; Mice, Inbred C57BL; ortho-Aminobenzoates; Pyrimidines; Rats, Wistar; Thiazoles; Thiophenes; Vasodilator Agents | 2015 |
Thiophene and benzodioxole appended thiazolyl-pyrazoline compounds: Microwave assisted synthesis, antimicrobial and molecular docking studies.
Topics: Anti-Infective Agents; Benzodioxoles; Binding Sites; DNA Topoisomerase IV; Fungi; Gram-Negative Bacteria; Gram-Positive Bacteria; Microbial Sensitivity Tests; Microwaves; Molecular Docking Simulation; Protein Binding; Pyrazoles; Structure-Activity Relationship; Thermodynamics; Thiazoles; Thiophenes | 2015 |
AMP-Activated Protein Kinase Interacts with the Peroxisome Proliferator-Activated Receptor Delta to Induce Genes Affecting Fatty Acid Oxidation in Human Macrophages.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Acetyl-CoA C-Acyltransferase; AMP-Activated Protein Kinases; Analysis of Variance; Biphenyl Compounds; Blotting, Western; Carbon-Carbon Double Bond Isomerases; DNA Primers; Enoyl-CoA Hydratase; Gene Expression Regulation; Humans; Macrophages; Microarray Analysis; Mutagenesis, Site-Directed; Oxygen Consumption; Plasmids; PPAR delta; Pyrones; Racemases and Epimerases; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Thiophenes | 2015 |
Chronic peroxisome proliferator-activated receptorβ/δ agonist GW0742 prevents hypertension, vascular inflammatory and oxidative status, and endothelial dysfunction in diet-induced obesity.
Topics: Adiponectin; Adipose Tissue; Animals; Aorta; Blood Glucose; Caveolin 1; Diet, High-Fat; Endothelium, Vascular; Glucose Tolerance Test; Hypertension; Insulin Resistance; Interleukin-6; Male; Mice; Nitric Oxide Synthase Type III; Obesity; PPAR delta; PPAR-beta; Reactive Oxygen Species; Sulfones; Thiazoles; Thiophenes; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha; Vasodilation | 2015 |
Carnitine palmitoyltransferase-1 up-regulation by PPAR-β/δ prevents lipid-induced endothelial dysfunction.
Topics: Animals; Aorta; Blotting, Western; Calcimycin; Carnitine O-Palmitoyltransferase; Cells, Cultured; Diglycerides; Endothelium, Vascular; Enzyme Activation; Lipids; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase Type III; Palmitic Acids; Phosphorylation; PPAR delta; PPAR-beta; Protein Kinase C-alpha; Reactive Oxygen Species; RNA Interference; Sulfones; Thiazoles; Thiophenes; Up-Regulation | 2015 |
Protective Effect of Unsaturated Fatty Acids on Palmitic Acid-Induced Toxicity in Skeletal Muscle Cells is not Mediated by PPARδ Activation.
Topics: Animals; Cell Death; Cell Line; Cell Survival; Dietary Fats, Unsaturated; Gene Expression Regulation, Enzymologic; Mice; Muscle Cells; Muscle, Skeletal; Palmitic Acid; Receptors, Cytoplasmic and Nuclear; Sulfones; Thiazoles; Thiophenes | 2015 |
Palladium-Catalyzed Heteroarylation and Concomitant ortho-Alkylation of Aryl Iodides.
Topics: Alkylation; Catalysis; Hydrocarbons, Iodinated; Iodides; Molecular Structure; Organometallic Compounds; Oxazoles; Palladium; Thiazoles; Thiophenes | 2015 |
Peroxisome proliferator-activated receptor δ inhibits Porphyromonas gingivalis lipopolysaccharide-induced activation of matrix metalloproteinase-2 by downregulating NADPH oxidase 4 in human gingival fibroblasts.
Topics: Cells, Cultured; Collagen; Down-Regulation; Enzyme Activation; Fibroblasts; Gingiva; Humans; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Matrix Metalloproteinase 2; NADPH Oxidase 4; NADPH Oxidases; p38 Mitogen-Activated Protein Kinases; Porphyromonas gingivalis; PPAR delta; Reactive Oxygen Species; RNA, Small Interfering; Sulfones; Thiazoles; Thiophenes | 2016 |
Fragment-Based Discovery of Subtype-Selective Adenosine Receptor Ligands from Homology Models.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A3 Receptor Antagonists; Animals; Binding, Competitive; CHO Cells; Computer Simulation; Cricetulus; High-Throughput Screening Assays; Humans; Ligands; Molecular Docking Simulation; Pyrimidinones; Receptor, Adenosine A1; Receptor, Adenosine A3; Sequence Homology, Amino Acid; Small Molecule Libraries; Structure-Activity Relationship; Thiazoles; Thiophenes | 2015 |
Synthesis and evaluation of 6-(3-[(18)F]fluoro-2-hydroxypropyl)-substituted 2-pyridylbenzothiophenes and 2-pyridylbenzothiazoles as potential PET tracers for imaging Aβ plaques.
Topics: Amyloid beta-Peptides; Animals; Brain; Mice; Positron-Emission Tomography; Thiazoles; Thiophenes | 2016 |
Role of UCP2 in the protective effects of PPARβ/δ activation on lipopolysaccharide-induced endothelial dysfunction.
Topics: Animals; Aorta; Calcimycin; Cytochrome b Group; Endoplasmic Reticulum Stress; Endothelial Cells; Endothelium, Vascular; Gene Expression Regulation; Inflammation; Lipopolysaccharides; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; NADPH Oxidase 2; NADPH Oxidases; Nitric Oxide; PPAR gamma; PPAR-beta; Primary Cell Culture; Reactive Oxygen Species; RNA, Small Interfering; Signal Transduction; Sulfones; Thiazoles; Thiophenes; Tissue Culture Techniques; Uncoupling Protein 2 | 2016 |
Vascular and Central Activation of Peroxisome Proliferator-Activated Receptor-β Attenuates Angiotensin II-Induced Hypertension: Role of RGS-5.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Male; Mesenteric Arteries; Mice, Inbred C57BL; Norepinephrine; PPAR-beta; RGS Proteins; Sulfones; Thiazoles; Thiophenes; Vascular Resistance; Vasoconstriction | 2016 |
Novel quinolines carrying pyridine, thienopyridine, isoquinoline, thiazolidine, thiazole and thiophene moieties as potential anticancer agents.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Female; Humans; Inhibitory Concentration 50; Isoquinolines; MCF-7 Cells; Models, Molecular; Molecular Structure; Pyridines; Quinolines; Structure-Activity Relationship; Thiazoles; Thiazolidines; Thiophenes | 2016 |
Characterization of the Mouse and Human Monoacylglycerol O-Acyltransferase 1 (Mogat1) Promoter in Human Kidney Proximal Tubule and Rat Liver Cells.
Topics: Acyltransferases; Anilides; Animals; Blotting, Northern; Caco-2 Cells; Cell Line; Cell Line, Tumor; Chromatin Immunoprecipitation; Computational Biology; HT29 Cells; Humans; Kidney Tubules, Proximal; Liver; Mice; Oxazoles; PPAR alpha; Promoter Regions, Genetic; Pyrimidines; Rats; Real-Time Polymerase Chain Reaction; Rosiglitazone; Sulfones; Thiazoles; Thiazolidinediones; Thiophenes; Tyrosine | 2016 |
Synthesis and Characterization of Some New Bis-Pyrazolyl-Thiazoles Incorporating the Thiophene Moiety as Potent Anti-Tumor Agents.
Topics: Antineoplastic Agents; Carbon-13 Magnetic Resonance Spectroscopy; Cell Survival; Chemistry, Pharmaceutical; Drug Screening Assays, Antitumor; Hep G2 Cells; Humans; Inhibitory Concentration 50; Molecular Structure; Proton Magnetic Resonance Spectroscopy; Pyrazoles; Structure-Activity Relationship; Thiazoles; Thiophenes | 2016 |
Inhibition of calcium-activated chloride channel ANO1 suppresses proliferation and induces apoptosis of epithelium originated cancer cells.
Topics: Anoctamin-1; Antineoplastic Agents; Apoptosis; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; HCT116 Cells; HEK293 Cells; HT29 Cells; Humans; Neoplasm Proteins; Neoplasms, Glandular and Epithelial; Pyrimidines; RNA Interference; Signal Transduction; Thiazoles; Thiophenes; Time Factors; Transfection | 2016 |
Anionic Oligothiophenes Compete for Binding of X-34 but not PIB to Recombinant Aβ Amyloid Fibrils and Alzheimer's Disease Brain-Derived Aβ.
Topics: Alkenes; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzoates; Brain; Humans; Positron-Emission Tomography; Thiazoles; Thiophenes | 2016 |
The AMPK Activator A769662 Blocks Voltage-Gated Sodium Channels: Discovery of a Novel Pharmacophore with Potential Utility for Analgesic Development.
Topics: AMP-Activated Protein Kinases; Analgesics; Anesthetics, Local; Animals; Binding Sites; Biphenyl Compounds; Drug Evaluation, Preclinical; HEK293 Cells; Hot Temperature; Humans; Male; meta-Aminobenzoates; Metformin; NAV1.7 Voltage-Gated Sodium Channel; Neural Conduction; Pain; Patch-Clamp Techniques; Pyrones; Rats; Rats, Sprague-Dawley; Reaction Time; Recombinant Fusion Proteins; Resveratrol; Sensory Receptor Cells; Sodium Channel Blockers; Stilbenes; Thiazoles; Thiophenes; Trigeminal Ganglion | 2017 |
Imidazo[1,2-a]pyridines linked with thiazoles/thiophene motif through keto spacer as potential cytotoxic agents and NF-κB inhibitors.
Topics: A549 Cells; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Drug Screening Assays, Antitumor; HeLa Cells; Humans; NF-kappa B; Pyridines; Structure-Activity Relationship; Thiazoles; Thiophenes | 2017 |
LY2087101 and dFBr share transmembrane binding sites in the (α4)3(β2)2 Nicotinic Acetylcholine Receptor.
Topics: Allosteric Regulation; Amino Acid Substitution; Animals; Binding Sites; Humans; Hydrocarbons, Brominated; Indole Alkaloids; Molecular Docking Simulation; Protein Binding; Receptors, Nicotinic; Thiazoles; Thiophenes; Xenopus | 2018 |
Synthesis of Novel Thiophene, Thiazole and Coumarin Derivatives Based on Benzimidazole Nucleus and Their Cytotoxicity and Toxicity Evaluations.
Topics: Anilides; Animals; Antineoplastic Agents; Benzimidazoles; Cell Line, Tumor; Cell Proliferation; Coumarins; Decapoda; Drug Screening Assays, Antitumor; Humans; Larva; Quinolines; Structure-Activity Relationship; Thiazoles; Thiophenes | 2018 |
Dibenzofuran, dibenzothiophene and N-methyl carbazole tethered 2-aminothiazoles and their cinnamamides as potent inhibitors of Mycobacterium tuberculosis.
Topics: Anti-Bacterial Agents; Benzofurans; Carbazoles; Cell Survival; Cinnamates; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Structure-Activity Relationship; Thiazoles; Thiophenes | 2018 |
Delayed activation of PPAR-β/δ improves long-term survival in mouse sepsis: effects on organ inflammation and coagulation.
Topics: Animals; Blood Coagulation; Cytokines; Female; Inflammation; Mice; PPAR delta; PPAR-beta; Sepsis; Sulfones; Thiazoles; Thiophenes | 2018 |
Transcriptional regulation by promoters with enhancer function.
Topics: Animals; CRISPR-Cas Systems; Drosophila; Enhancer Elements, Genetic; Gene Editing; Gene Expression Regulation; HeLa Cells; Humans; Indoles; Interferons; K562 Cells; Mice; Mice, Knockout; Promoter Regions, Genetic; Pyrimidines; Thiazoles; Thiophenes; Transcription, Genetic | 2018 |
Population Pharmacokinetic/Pharmacodynamic Analyses of Avatrombopag in Patients With Chronic Liver Disease and Optimal Dose Adjustment Guide With Concomitantly Administered CYP3A and CYP2C9 Inhibitors.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Computer Simulation; Cytochrome P-450 CYP2C9 Inhibitors; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; End Stage Liver Disease; Female; Humans; Male; Middle Aged; Models, Biological; Thiazoles; Thiophenes; Thrombocytopenia; Young Adult | 2018 |
Relative potency of the thrombopoietin receptor agonists eltrombopag, avatrombopag and romiplostim in a patient with chronic immune thrombocytopenia.
Topics: Benzoates; Dose-Response Relationship, Drug; Female; Hematologic Agents; Humans; Hydrazines; Middle Aged; Platelet Count; Purpura, Thrombocytopenic, Idiopathic; Pyrazoles; Receptors, Fc; Receptors, Thrombopoietin; Recombinant Fusion Proteins; Thiazoles; Thiophenes; Thrombopoietin; Treatment Outcome | 2018 |
Direct Reprogramming of Glioblastoma Cells into Neurons Using Small Molecules.
Topics: Basic Helix-Loop-Helix Transcription Factors; Brain Neoplasms; Cell Line, Tumor; Cellular Reprogramming; Cellular Reprogramming Techniques; Colforsin; Diamines; Glioblastoma; Heterocyclic Compounds, 4 or More Rings; Homeodomain Proteins; Humans; Isoxazoles; Microtubule-Associated Proteins; Nerve Tissue Proteins; Neurons; POU Domain Factors; Pyridines; Pyrimidines; Thiazoles; Thiophenes; Up-Regulation | 2018 |
GW0742 activates peroxisome proliferator-activated receptor δ to reduce free radicals and alleviate cardiac hypertrophy induced by hyperglycemia in cultured H9c2 cells.
Topics: Animals; Blotting, Western; Calcium; Cardiomegaly; Cell Line; Free Radicals; Hyperglycemia; Rats; Reactive Oxygen Species; Sulfones; Thiazoles; Thiophenes | 2018 |
First Drug Approved to Reduce Bleeding Risk During Medical Procedures in Patients with Chronic Liver Disease.
Topics: Drug Approval; End Stage Liver Disease; Humans; Receptors, Thrombopoietin; Thiazoles; Thiophenes; Thrombocytopenia | 2018 |
Effects of the Calcium-Activated Chloride Channel Inhibitors T16Ainh-A01 and CaCCinh-A01 on Cardiac Fibroblast Function.
Topics: Actins; Animals; Anoctamin-1; Calcium; Cell Cycle Checkpoints; Cell Movement; Cell Proliferation; Cells, Cultured; Chloride Channels; Chlorides; Collagen; Down-Regulation; Fibroblasts; Male; Myocytes, Cardiac; Pyrimidines; Rats; Rats, Sprague-Dawley; Thiazoles; Thiophenes | 2018 |
Uses of 2-(Thiophene-2-carbonylcarbamothioylthio)acetic Acid as a Good Synthon for Construction of Some New Thiazole and Annulated Thiazole Derivatives.
Topics: Acetates; Molecular Structure; Thiazoles; Thiophenes | 2018 |
Avatrombopag.
Topics: Humans; Purpura, Thrombocytopenic, Idiopathic; Thiazoles; Thiophenes | 2018 |
What Did We Learn From the ADAPT Trials?
Topics: Humans; Liver Diseases; Platelet Transfusion; Thiazoles; Thiophenes; Thrombocytopenia | 2019 |
Exploring the potential of Juglans regia-derived activated carbon for the removal of adsorbed fungicide Ethaboxam from soils.
Topics: Adsorption; Charcoal; Environmental Monitoring; Fungicides, Industrial; Juglans; Soil; Soil Pollutants; Spectroscopy, Fourier Transform Infrared; Thiazoles; Thiophenes | 2018 |
Effects of Ca2+-Activated Cl- Channel ANO1inhibitors on Pacemaker Activity in Interstitial Cells of Cajal.
Topics: Animals; Anoctamin-1; Calcium; Cells, Cultured; Female; Interstitial Cells of Cajal; Male; Membrane Potentials; Mice; Mice, Inbred BALB C; ortho-Aminobenzoates; Patch-Clamp Techniques; Pyrimidines; Thiazoles; Thiophenes | 2018 |
Convergent Evolution of C239S Mutation in
Topics: Drug Resistance, Fungal; Evolution, Molecular; Mutation; Pythium; Thiazoles; Thiophenes; Tubulin | 2019 |
PPARδ agonist prevents endothelial dysfunction via induction of dihydrofolate reductase gene and activation of tetrahydrobiopterin salvage pathway.
Topics: Animals; Aorta; Biopterins; Cells, Cultured; Endothelium, Vascular; Gene Expression; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice, Inbred C57BL; Mice, Knockout; PPAR delta; Sulfones; Tetrahydrofolate Dehydrogenase; Thiazoles; Thiophenes; Thoracic Arteries | 2019 |
Biochemical Inhibition of DOG1/TMEM16A Achieves Antitumoral Effects in Human Gastrointestinal Stromal Tumor Cells
Topics: Anoctamin-1; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Gastrointestinal Neoplasms; Gastrointestinal Stromal Tumors; Humans; Neoplasm Proteins; Pyrimidines; Thiazoles; Thiophenes | 2019 |
Heterocyclization of 2-Arylidenecyclohexan-1,3-dione: Synthesis of Thiophene, Thiazole, and Isoxazole Derivatives with Potential Antitumor Activities.
Topics: Acetates; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cyclization; Cyclohexanones; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Isoxazoles; Molecular Structure; Nitriles; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Proto-Oncogene Proteins c-pim-1; src-Family Kinases; Structure-Activity Relationship; Thiazoles; Thiophenes | 2020 |
The effect of two selective A
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Aminopyridines; Animals; Cardiovascular System; Consciousness; Drug Partial Agonism; Heart Rate; Hemodynamics; Ligands; Male; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Regional Blood Flow; Thiazoles; Thiophenes | 2020 |
Benzo[b]thiophene-thiazoles as potent anti-Toxoplasma gondii agents: Design, synthesis, tyrosinase/tyrosine hydroxylase inhibitors, molecular docking study, and antioxidant activity.
Topics: Animals; Antioxidants; Antiprotozoal Agents; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Design; Enzyme Inhibitors; Mice; Molecular Docking Simulation; Molecular Structure; Monophenol Monooxygenase; Structure-Activity Relationship; Thiazoles; Thiophenes; Toxoplasma; Tyrosine 3-Monooxygenase | 2019 |
New Drugs 2019, part 4.
Topics: Aminopyridines; Cinnamates; Drug Approval; Factor Xa; Humans; Macrolides; Morpholines; Oligonucleotides; Oxazines; Pyridines; Pyrimidines; Recombinant Proteins; RNA, Small Interfering; Sisomicin; Tetracyclines; Thiazoles; Thiophenes; United States; United States Food and Drug Administration | 2019 |
Health Care Cost in Patients With Schizophrenia Treated With Brexpiprazole Versus Other Oral Atypical Antipsychotic Therapy.
Topics: Administration, Oral; Adult; Antipsychotic Agents; Aripiprazole; Female; Health Care Costs; Hospitalization; Humans; Lurasidone Hydrochloride; Male; Medicaid; Medicare; Middle Aged; Olanzapine; Paliperidone Palmitate; Piperazines; Quetiapine Fumarate; Quinolones; Risperidone; Schizophrenia; Thiazoles; Thiophenes; United States | 2020 |
Design, synthesis and evaluation of phenylthiazole and phenylthiophene pyrimidindiamine derivatives targeting the bacterial membrane.
Topics: Animals; Anti-Bacterial Agents; Bacteremia; Cell Membrane; Drug Design; Escherichia coli; Hemolysis; Male; Mice, Inbred C57BL; Microbial Sensitivity Tests; Molecular Structure; Pyrimidines; Rabbits; Staphylococcus aureus; Structure-Activity Relationship; Thiazoles; Thiophenes | 2020 |
The Efficacy of Ethaboxam as a Soybean Seed Treatment Toward
Topics: Glycine max; Ohio; Phytophthora; Plant Diseases; Pythium; Seeds; Thiazoles; Thiophenes | 2020 |
Cannabidiolic acid dampens the expression of cyclooxygenase-2 in MDA-MB-231 breast cancer cells: Possible implication of the peroxisome proliferator-activated receptor β/δ abrogation.
Topics: Breast Neoplasms; Cannabinoids; Cyclooxygenase 2; Female; Gene Expression; Humans; PPAR delta; Signal Transduction; Sulfones; Thiazoles; Thiophenes; Transcription Factor AP-1; Tumor Cells, Cultured | 2020 |
Human Endometrial Stromal Cell Differentiation is Stimulated by PPARβ/δ Activation: New Targets for Infertility?
Topics: Adult; Cell Differentiation; Cells, Cultured; Decidua; Endometrium; Female; Humans; Infertility, Female; Ligands; Molecular Targeted Therapy; PPAR delta; PPAR-beta; Stromal Cells; Sulfones; Thiazoles; Thiophenes; Up-Regulation | 2020 |
Periprocedural use of avatrombopag for neurosurgical interventions: a strategy to avoid platelet utilization.
Topics: Blood Platelets; Thiazoles; Thiophenes | 2020 |
AMP-independent activator of AMPK for treatment of mitochondrial disorders.
Topics: Allosteric Regulation; AMP-Activated Protein Kinases; Animals; Biphenyl Compounds; Cell Respiration; Cell Survival; Cells, Cultured; Disease Models, Animal; Enzyme Activation; Fibroblasts; Humans; meta-Aminobenzoates; Mice; Mitochondrial Diseases; Oxidative Stress; Oxygen Consumption; Pyrimidines; Pyrones; Thiazoles; Thiophenes | 2020 |
An evaluation of avatrombopag for the treatment of thrombocytopenia.
Topics: Humans; Liver Diseases; Purpura, Thrombocytopenic, Idiopathic; Thiazoles; Thiophenes; Thrombocytopenia | 2021 |
Chickpea Seed Rot and Damping-Off Caused by Metalaxyl-Resistant
Topics: Alanine; Cicer; Plant Diseases; Pythium; Seeds; Thiazoles; Thiophenes | 2021 |
Avatrombopag Optimizes Response to Niraparib by Managing Thrombocytopenia Associated with Poly-ADP Ribose Polymerase (PARP) Inhibition in Ovarian Cancer and Breast Cancer: A Case Series.
Topics: Adenosine Diphosphate Ribose; Breast Neoplasms; Female; Humans; Indazoles; Ovarian Neoplasms; Piperidines; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Thiazoles; Thiophenes; Thrombocytopenia | 2020 |
Pharmacological modulation of RORα controls fat browning, adaptive thermogenesis, and body weight in mice.
Topics: Adipocytes; Adipose Tissue, Brown; Adipose Tissue, White; Adult; Animals; Benzamides; Body Weight; Cell Transdifferentiation; Cells, Cultured; Cold-Shock Response; Female; Humans; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nuclear Receptor Subfamily 1, Group F, Member 1; Sulfonamides; Thermogenesis; Thiazoles; Thiophenes | 2021 |
The Uses of Dimedone for the Synthesis of Thiophene, Thiazole and Annulated Derivatives with Antitumor, Pim-1 Kinase Inhibitions, PAINS Evaluations and Molecular Docking.
Topics: Antineoplastic Agents; Cell Line; Cell Proliferation; Cyclohexanones; Drug Screening Assays, Antitumor; Humans; Molecular Docking Simulation; Molecular Structure; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-pim-1; Thiazoles; Thiophenes | 2021 |
Synthesis and in vitro Anticancer Activity of Novel Heterocycles Utilizing Thiophene Incorporated Thioureido Substituent as Precursors.
Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Pyrimidines; Structure-Activity Relationship; Thiazoles; Thiophenes; Thiourea | 2020 |
Multi-component Reactions of Cyclohexan-1,3-diketones to Produce Fused Pyran Derivatives with Antiproliferative Activities and Tyrosine Kinases and Pim-1 Kinase Inhibitions.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cyclohexanones; Drug Screening Assays, Antitumor; Humans; Hydrazones; Molecular Structure; Protein Kinase Inhibitors; Structure-Activity Relationship; Thiazoles; Thiophenes; Xanthenes | 2021 |
Second-generation thrombopoietin receptor agonists: New players in the management of cirrhotic patients undergoing therapeutic endoscopy?
Topics: Cinnamates; Endoscopy; Humans; Liver Cirrhosis; Receptors, Thrombopoietin; Surveys and Questionnaires; Thiazoles; Thiophenes; Thrombocytopenia | 2021 |
Clinical outcomes in eight patients with immune thrombocytopenia each treated with the three approved thrombopoietin receptor agonists.
Topics: Adult; Aged; Benzoates; Female; Humans; Hydrazines; Male; Middle Aged; Pyrazoles; Receptors, Fc; Receptors, Thrombopoietin; Recombinant Fusion Proteins; Thiazoles; Thiophenes; Thrombocytopenia; Thrombopoietin; Treatment Outcome | 2021 |
Real-Time Monitoring of Human Guanine Deaminase Activity by an Emissive Guanine Analog.
Topics: Enzyme Assays; Enzyme Inhibitors; Fluorescent Dyes; Guanine Deaminase; Humans; Kinetics; Pyrimidines; Thiazoles; Thiophenes | 2021 |
ER+ Breast Cancer Strongly Depends on MCL-1 and BCL-xL Anti-Apoptotic Proteins.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-X Protein; Breast Neoplasms; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Synergism; Estrogen Receptor alpha; Everolimus; Female; Fulvestrant; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Myeloid Cell Leukemia Sequence 1 Protein; Piperazines; Protein Isoforms; Proto-Oncogene Proteins c-akt; Pyridines; Pyrimidines; Signal Transduction; Sulfonamides; Thiazoles; Thiophenes | 2021 |
A Phase I Study of LSZ102, an Oral Selective Estrogen Receptor Degrader, with or without Ribociclib or Alpelisib, in Patients with Estrogen Receptor-Positive Breast Cancer.
Topics: Adult; Aminopyridines; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Humans; Purines; Receptors, Estrogen; Thiazoles; Thiophenes | 2021 |
Avatrombopag Use in Patient With Thromboembolic Risks Listed for Combined Coronary Artery Bypass Grafting and Liver Transplant: A Case Report.
Topics: Coronary Artery Bypass; Humans; Liver Transplantation; Thiazoles; Thiophenes | 2021 |
Anti-proliferative, c-Met Inhibitions, and PAINS Evaluations of New Thiophene, Thiazole, Coumarin, Pyran, and Pyridine Derivatives.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Coumarins; Cyclohexanes; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Protein Kinase Inhibitors; Pyrans; Pyridines; Structure-Activity Relationship; Thiazoles; Thiophenes | 2022 |
Severe aplastic anemia in a patient with erythropoietic protoporphyria successfully treated by avatrombopag.
Topics: Anemia, Aplastic; Humans; Protoporphyria, Erythropoietic; Thiazoles; Thiophenes | 2022 |
Avatrombopag Effectively Maintained Platelet Counts in a Patient with Immune Thrombocytopenia Who Was Intolerant to Tyrosine Kinase Inhibitor Therapy.
Topics: Female; Humans; Middle Aged; Platelet Count; Protein Kinase Inhibitors; Purpura, Thrombocytopenic, Idiopathic; Thiazoles; Thiophenes | 2021 |
Avatrombopag improves thrombocytopenia in MYH9-related disorder following eltrombopag treatment failure.
Topics: Benzoates; Hearing Loss, Sensorineural; Humans; Hydrazines; Male; Molecular Motor Proteins; Mutation; Myosin Heavy Chains; Pyrazoles; Thiazoles; Thiophenes; Thrombocytopenia; Treatment Failure | 2022 |
An updated evaluation of avatrombopag for the treatment of chronic immune thrombocytopenia.
Topics: Humans; Purpura, Thrombocytopenic, Idiopathic; Receptors, Thrombopoietin; Recombinant Fusion Proteins; Thiazoles; Thiophenes | 2022 |
Synthesis, Molecular Docking Study, and Cytotoxic Activity against MCF Cells of New Thiazole-Thiophene Scaffolds.
Topics: Antineoplastic Agents; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; MCF-7 Cells; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship; Thiazoles; Thiophenes | 2022 |
Enhanced Photovoltaic Properties of Y6 Derivatives with Asymmetric Terminal Groups: A Theoretical Insight.
Topics: Bandages; Electron Transport; Electrons; Thiazoles; Thiophenes | 2023 |