thiazoles has been researched along with sphingosine in 45 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.22) | 18.7374 |
| 1990's | 4 (8.89) | 18.2507 |
| 2000's | 17 (37.78) | 29.6817 |
| 2010's | 22 (48.89) | 24.3611 |
| 2020's | 1 (2.22) | 2.80 |
| Authors | Studies |
|---|---|
| Desai, NN; Mattie, ME; Olivera, A; Spiegel, S; Zhang, H | 1 |
| Kanoh, H; Sakane, F; Yamada, K | 1 |
| Herrington, J; Iwata, M; Zager, RA | 1 |
| Imoto, K; Kaneko, M; Ohshika, H; Sakano, S; Takemura, H; Yamada, K | 1 |
| McKay, C; Miller, A | 1 |
| Lobner, D | 1 |
| Brindley, D; Degerman, E; Holm, C; Holst, LS; Landström, TR; Manganiello, V; Mei, J | 1 |
| Endo, A; Hasegawa, T; Koide, Y; Mochizuki, N; Nakagawa, M; Nishida, A; Takahashi, A | 1 |
| Becker, KP; Bielawski, J; Johnson, KR; Johnson, KY; Mao, C; Obeid, LM | 1 |
| Gentil, B; Grimot, F; Riva, C | 1 |
| Gonska, H; Kim, DS; Kleuser, B; Manggau, M; Sauer, B; Schäfer-Korting, M; Schraut, C | 1 |
| Coelho, RP; Goparaju, SK; Jolly, PS; Maceyka, M; Saini, HS; Sato-Bigbee, C; Spiegel, S | 1 |
| Bergelin, N; Blom, T; Slotte, JP; Törnquist, K | 1 |
| Chen, H; Chen, S; Hsu, CY; Lee, JM; Xu, J; Zeng, C | 1 |
| French, KJ; Keller, SN; Smith, CD; Upson, JJ; Yun, JK; Zhuang, Y | 1 |
| Arboleda, G; Gibson, R; Waters, C | 1 |
| Blaser, BW; Bloomfield, CD; Byrd, JC; Caligiuri, MA; Chen, CS; Cortes, J; Druker, BJ; Eiring, AM; Gambacorti-Passerini, C; Liu, S; Marcucci, G; Muthusamy, N; Neviani, P; Notari, M; Oaks, JJ; Perrotti, D; Roy, DC; Santhanam, R; Trotta, R; Verrills, NM | 1 |
| Auzenne, E; Evans, R; Farquhar, D; Ghosh, SC; Hail, N; Klostergaard, J; Leroux, ME; McDonnell, T; Spohn, W | 1 |
| Chen, S; Sun, J; Yan, G; You, B | 1 |
| Jahangeer, S; Kotani, Y; Kuramoto, E; Nakamura, S; Nishimura, Y; Nishiuma, T; Okada, T | 1 |
| Cho, JY | 1 |
| Baur, F; Fozard, JR; Trifilieff, A | 1 |
| Hauser, CJ; Itagaki, K; Zhang, Q | 1 |
| Chiba, Y; Misawa, M; Sakai, H; Takeuchi, H | 1 |
| Highkin, MK; Lamarr, WA; Masferrer, JL; Munie, GE; Nagiec, MM; Nemirovskiy, OV; Rains, JW; Yates, MP | 1 |
| Kanno, T; Nishizaki, T | 2 |
| Allen, JD; Alling, N; Haass, NK; Jackson, EA; Martinello-Wilks, R; McGowan, EM; Yagoub, D | 1 |
| Fox, TE; Gowda, R; Hengst, J; Madhunapantula, SV; Robertson, GP; Yun, JK | 1 |
| Alossaimi, M; Bittman, R; Chan, E; Pyne, NJ; Pyne, S; Tate, RJ; Tonelli, F; Watson, DG; Williamson, L | 1 |
| Bauer, Y; Bolli, MH; Gatfield, J; Killer, N; Menyhart, K; Nayler, O; Renault, B; Sobel, K; Steiner, B; Studer, R | 1 |
| Buist-Homan, M; Combettes, L; de Boer, JF; Faber, KN; Karimian, G; Klappe, K; Kok, JW; Moshage, H; Schmidt, M; Tietge, UJ; Tordjmann, T | 1 |
| Bai, A; Bielawska, A; Bielawski, J; Boppana, NB; Breen, P; Gudz, TI; Joseph, N; Korbelik, M; Kraveka, JM; Li, L; Pierce, JS; Rahmaniyan, M; Separovic, D; Van Buren, E | 1 |
| He, HW; Shao, RG; Zhang, CX | 1 |
| Bittman, R; Ohotski, J; Pyne, NJ; Pyne, S; Rosen, H | 1 |
| Bolli, MH; Gatfield, J; Monnier, L; Nayler, O; Steiner, B; Studer, R | 1 |
| Bieberich, E; Bryant, L; Chen, C; Chen, Z; Cuzzocrea, S; Doyle, T; Esposito, E; Janes, K; Kamocki, K; Li, C; Little, JW; Neumann, WL; Nicol, G; Obeid, L; Petrache, I; Salvemini, D; Snider, A | 1 |
| Beak, DJ; Bertaina, A; Bittman, R; Chiarini, F; Evangelisti, C; Falconi, M; Locatelli, F; Martelli, AM; McCubrey, JA; Melchionda, F; Pession, A; Pyne, NJ; Pyne, S; Teti, G | 1 |
| Burkhardt, R; Ceglarek, U; Nofer, JR; Potì, F; Simoni, M | 1 |
| Arai, K; Herr, DR; Lai, MK; Torta, F; Wenk, MR; Wong, PT; Yang, Y | 1 |
| Sadik, CD; Thieme, M; Zillikens, D | 1 |
| Angioni, C; Brüne, B; Ferreirós, N; Giegerich, AK; Knape, T; Kuchler, L; Schmidt, MV; Sha, LK; von Knethen, A; Weigert, A | 1 |
| Cao, Y; Gao, J; Hao, Y; Sun, C; Wang, J; Wu, H; Wu, L; Xia, W; Zhang, Q | 1 |
| Hahm, B; Seo, YJ; Studstill, CJ; Vijayan, M; Wolf, JJ; Xia, C | 1 |
| Alnaif, A; D'Souza, MS; Oiler, I | 1 |
3 review(s) available for thiazoles and sphingosine
| Article | Year |
|---|---|
[Sphingosine kinase 1 and tumor].
Topics: Amino Alcohols; Animals; Apoptosis; Cell Movement; Cell Proliferation; Ceramides; Enzyme Activation; Enzyme Inhibitors; Humans; Lysophospholipids; Neoplasms; Neovascularization, Pathologic; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Sphingosine; Thiazoles | 2013 |
Sphingosine-1-phosphate modulators in inflammatory skin diseases - lining up for clinical translation.
Topics: Animals; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Lymphocytes; Lysophospholipids; Receptors, Lymphocyte Homing; Receptors, Lysophospholipid; Skin Diseases; Sphingosine; Thiazoles | 2017 |
Ponesimod: An Oral Second-Generation Selective Sphingosine 1-Phosphate Receptor Modulator for the Treatment of Multiple Sclerosis.
Topics: Humans; Immunologic Factors; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Sphingosine; Sphingosine-1-Phosphate Receptors; Thiazoles | 2023 |
42 other study(ies) available for thiazoles and sphingosine
| Article | Year |
|---|---|
Sphingosine-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation.
Topics: 3T3 Cells; Animals; Diglycerides; Dose-Response Relationship, Drug; Enzyme Activation; Kinetics; Lysophospholipids; Mice; Phosphatidate Phosphatase; Phosphatidic Acids; Phospholipase D; Pyrimidinones; Sphingosine; Thiazoles | 1992 |
Different effects of sphingosine, R59022 and anionic amphiphiles on two diacylglycerol kinase isozymes purified from porcine thymus cytosol.
Topics: Animals; Chromatography, Ion Exchange; Cytosol; Deoxycholic Acid; Diacylglycerol Kinase; Electrophoresis, Polyacrylamide Gel; Isoenzymes; Kinetics; Phosphatidylserines; Phosphotransferases; Pyrimidinones; Sphingosine; Swine; Thiazoles; Thymus Gland | 1989 |
Sphingosine: a mediator of acute renal tubular injury and subsequent cytoresistance.
Topics: Acute Kidney Injury; Adenosine Triphosphate; Calcium; Cell Survival; Cells, Cultured; Ceramides; Dose-Response Relationship, Drug; Fibroblasts; Humans; Ionophores; Kidney Tubules, Proximal; Male; Penis; Remission, Spontaneous; Sphingosine; Tetrazolium Salts; Thiazoles | 1995 |
Ca2+ mobilizing action of sphingosine in Jurkat human leukemia T cells. Evidence that sphingosine releases Ca2+ from inositol trisphosphate- and phosphatidic acid-sensitive intracellular stores through a mechanism independent of inositol trisphosphate.
Topics: Amines; Calcium; Cell Line; Ceramides; Diacylglycerol Kinase; Diglycerides; Enzyme Inhibitors; Humans; Inositol 1,4,5-Trisphosphate; Kinetics; Leukemia, T-Cell; Models, Biological; Muromonab-CD3; Phosphatidic Acids; Phosphotransferases (Alcohol Group Acceptor); Psychosine; Pyrimidinones; Sphingosine; Terpenes; Thapsigargin; Thiazoles; Tumor Cells, Cultured | 1996 |
Relationship among cellular diacylglycerol, sphingosine formation, protein kinase C activity, and parathyroid hormone secretion from dispersed bovine parathyroid cells.
Topics: Animals; Calcium; Cattle; Diacylglycerol Kinase; Diglycerides; Enzyme Inhibitors; Parathyroid Glands; Parathyroid Hormone; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Pyrimidinones; Sphingosine; Tetradecanoylphorbol Acetate; Thiazoles | 1996 |
Comparison of the LDH and MTT assays for quantifying cell death: validity for neuronal apoptosis?
Topics: Animals; Apoptosis; Cell Count; Cell Death; Cells, Cultured; Cerebral Cortex; Coloring Agents; Cycloheximide; Enzyme Inhibitors; Fetus; L-Lactate Dehydrogenase; Mice; Nerve Growth Factors; Neuroglia; Neurons; Neuroprotective Agents; Reproducibility of Results; Sphingosine; Tetrazolium Salts; Thiazoles; Trypan Blue | 2000 |
C(2)-ceramide influences the expression and insulin-mediated regulation of cyclic nucleotide phosphodiesterase 3B and lipolysis in 3T3-L1 adipocytes.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3T3 Cells; Adipocytes; Animals; Blotting, Western; Chromans; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 3; Drug Interactions; Enzyme Inhibitors; Insulin; Insulin Resistance; Isoquinolines; Lipolysis; Mice; Receptors, Cytoplasmic and Nuclear; Sphingosine; Sulfonamides; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Necrosis Factor-alpha | 2002 |
Development of novel EDG3 antagonists using a 3D database search and their structure-activity relationships.
Topics: Databases, Factual; DNA-Binding Proteins; HeLa Cells; Humans; I-kappa B Proteins; Lysophospholipids; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; NF-KappaB Inhibitor alpha; Quantitative Structure-Activity Relationship; Receptors, Lysophospholipid; Sphingosine; Stereoisomerism; Thiazines; Thiazoles | 2002 |
Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability.
Topics: Amino Acid Sequence; Animals; Blotting, Northern; Cell Division; Cell Line; Cell Survival; Cloning, Molecular; Coloring Agents; DNA, Complementary; Endoplasmic Reticulum; Gene Expression Regulation, Enzymologic; Humans; Lysophospholipids; Membrane Proteins; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Models, Biological; Molecular Sequence Data; Phosphoric Monoester Hydrolases; Protein Isoforms; Protein Structure, Tertiary; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Sequence Homology, Amino Acid; Signal Transduction; Sphingolipids; Sphingosine; Tetrazolium Salts; Thiazoles; Time Factors; Tissue Distribution; Tumor Cells, Cultured | 2003 |
Commitment to apoptosis by ceramides depends on mitochondrial respiratory function, cytochrome c release and caspase-3 activation in Hep-G2 cells.
Topics: Apoptosis; Caspase 3; Caspases; Cell Line; Cell Line, Tumor; Cell Nucleus; Cell Survival; Ceramides; Coloring Agents; Cytochromes c; DNA; DNA Fragmentation; Dose-Response Relationship, Drug; Electron Transport; Electrophoresis, Agar Gel; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Flow Cytometry; Humans; Microscopy, Fluorescence; Mitochondria; Reactive Oxygen Species; Sphingosine; Tetrazolium Salts; Thiazoles; Time Factors | 2003 |
Sphingosine 1-phosphate is involved in cytoprotective actions of calcitriol in human fibroblasts and enhances the intracellular Bcl-2/Bax rheostat.
Topics: Annexin A5; Apoptosis; bcl-2-Associated X Protein; Calcitriol; Cell Proliferation; Cell Survival; Cells, Cultured; Ceramides; DNA; Down-Regulation; Fibroblasts; Flow Cytometry; Genes, bcl-2; Humans; Immunoblotting; Lysophospholipids; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Sphingosine; Tetrazolium Salts; Thiazoles; Tumor Necrosis Factor-alpha | 2005 |
Novel role of sphingosine kinase 1 as a mediator of neurotrophin-3 action in oligodendrocyte progenitors.
Topics: Animals; Animals, Newborn; Blotting, Western; Cell Membrane; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Drug Interactions; Gene Expression Regulation; In Situ Nick-End Labeling; Lysophospholipids; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Neurotrophin 3; Oligodendroglia; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Sphingosine; Stem Cells; Thiazoles; Thiazolidinediones; Thiones; Time Factors | 2005 |
Sphingosine kinase regulates voltage operated calcium channels in GH4C1 rat pituitary cells.
Topics: Animals; Calcium; Calcium Channels; Cell Line; Membrane Potentials; Molecular Structure; Patch-Clamp Techniques; Phosphotransferases (Alcohol Group Acceptor); Pituitary Gland; Rats; Sphingosine; Thiazoles | 2006 |
Amyloid beta peptide increases DP5 expression via activation of neutral sphingomyelinase and JNK in oligodendrocytes.
Topics: Amyloid beta-Peptides; Animals; Apoptosis Regulatory Proteins; Blotting, Western; Brain; Cell Death; Cell Fractionation; Cell Nucleus; Cytosol; Embryo, Mammalian; Enzyme Activation; Enzyme Inhibitors; MAP Kinase Kinase 4; Neuropeptides; Oligodendroglia; Phosphorylation; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Sphingomyelin Phosphodiesterase; Sphingosine; Tetrazolium Salts; Thiazoles; Time Factors; Transcription Factor AP-1 | 2006 |
Antitumor activity of sphingosine kinase inhibitors.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Female; Half-Life; Lysophospholipids; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Multidrug Resistance-Associated Proteins; Phosphotransferases (Alcohol Group Acceptor); Proto-Oncogene Proteins c-akt; Sphingosine; Thiazoles | 2006 |
Inhibition of caspases but not of calpains temporarily protect against C2-ceramide-induced death of CAD cells.
Topics: Analysis of Variance; Animals; Calpain; Caspases; Cell Death; Cell Line; Dipeptides; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Mice; Neurons; Neuroprotective Agents; Sphingosine; Tetrazolium Salts; Thiazoles; Time Factors | 2007 |
FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia.
Topics: Animals; Benzamides; Blast Crisis; Cell Survival; Dasatinib; Drug Resistance, Neoplasm; Fingolimod Hydrochloride; Fusion Proteins, bcr-abl; Gene Expression Regulation, Neoplastic; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Molecular Structure; Phosphoprotein Phosphatases; Phosphorylation; Piperazines; Propylene Glycols; Protein Phosphatase 2; Pyrimidines; Signal Transduction; Sphingosine; Thiazoles; Time Factors; Tumor Cells, Cultured | 2007 |
Sphingolipids and the sphingosine kinase inhibitor, SKI II, induce BCL-2-independent apoptosis in human prostatic adenocarcinoma cells.
Topics: Adenocarcinoma; Apoptosis; Cell Line, Tumor; Cell Survival; Ceramides; Down-Regulation; Enzyme Inhibitors; Humans; Male; Phosphotransferases (Alcohol Group Acceptor); Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Sphingosine; Thiazoles | 2007 |
Activation of sphingosine kinase-1 mediates induction of endothelial cell proliferation and angiogenesis by epoxyeicosatrienoic acids.
Topics: 8,11,14-Eicosatrienoic Acid; Cell Movement; Cell Proliferation; Cells, Cultured; Endothelial Cells; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Humans; Lysophospholipids; Neovascularization, Physiologic; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Small Interfering; Signal Transduction; Sphingosine; Thiazoles | 2008 |
Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model.
Topics: Administration, Inhalation; Aniline Compounds; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cells, Cultured; Chemokines, CC; Disease Models, Animal; Enzyme Inhibitors; Goblet Cells; Humans; Hyperplasia; Interleukins; Lysophospholipids; Mice; Mice, Inbred C57BL; Ovalbumin; Phosphotransferases (Alcohol Group Acceptor); Respiratory Mucosa; Sphingosine; Thiazoles | 2008 |
Non-specific anti-proliferative effect of FTY720, a derivative of fungal metabolite from Iscaria sinclarii.
Topics: Aniline Compounds; Animals; Antibiotics, Antineoplastic; Cell Proliferation; Crotonates; Cyclosporine; Fingolimod Hydrochloride; Fungi; Hydroxybutyrates; Immunity, Cellular; Immunosuppressive Agents; Interleukin-2; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nitric Oxide; Nitriles; Propylene Glycols; Sphingosine; T-Lymphocytes; Tetrazolium Salts; Thiazoles; Toluidines; Tumor Necrosis Factor-alpha | 2008 |
Role of sphingosine-1-phosphate (S1P) and the S1P(2) receptor in allergen-induced, mast cell-dependent contraction of rat lung parenchymal strips.
Topics: Acetates; Adenosine; Allergens; Animals; Bronchoconstriction; Cyclopropanes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Injections, Subcutaneous; Leukotriene Antagonists; Lung; Lysophospholipids; Male; Mast Cells; Methysergide; Ovalbumin; Phosphotransferases (Alcohol Group Acceptor); Pyrazoles; Pyridines; Quinolines; Rats; Rats, Inbred BN; Receptors, Lysosphingolipid; Serotonin; Serotonin Antagonists; Signal Transduction; Sphingosine; Sulfides; Thiazoles | 2009 |
Sphingosine kinase inhibition alleviates endothelial permeability induced by thrombin and activated neutrophils.
Topics: Aminophenols; Calcium; Capillary Permeability; Cells, Cultured; Computer Systems; Endothelial Cells; Gadolinium; Humans; Neutrophils; Nitrendipine; Phosphotransferases (Alcohol Group Acceptor); Sphingosine; Thapsigargin; Thiazoles; Thrombin | 2010 |
SKI-II, an inhibitor of sphingosine kinase, ameliorates antigen-induced bronchial smooth muscle hyperresponsiveness, but not airway inflammation, in mice.
Topics: Animals; Antigens; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Immunoglobulin E; Interleukin-13; Interleukin-4; Lysophospholipids; Male; Mice; Mice, Inbred BALB C; Muscle, Smooth; Phosphotransferases (Alcohol Group Acceptor); Sphingosine; Thiazoles | 2010 |
High-throughput screening assay for sphingosine kinase inhibitors in whole blood using RapidFire® mass spectrometry.
Topics: Aminophenols; Dose-Response Relationship, Drug; Enzyme Inhibitors; High-Throughput Screening Assays; Humans; Kinetics; Lysophospholipids; Mass Spectrometry; Phosphotransferases (Alcohol Group Acceptor); Signal Transduction; Sphingosine; Thiazoles | 2011 |
Sphingosine induces apoptosis in hippocampal neurons and astrocytes by activating caspase-3/-9 via a mitochondrial pathway linked to SDK/14-3-3 protein/Bax/cytochrome c.
Topics: 14-3-3 Proteins; Animals; Apoptosis; Astrocytes; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Cells, Cultured; Cytochromes c; Enzyme Activation; Hippocampus; Intracellular Space; Membrane Potential, Mitochondrial; Mitochondria; Neurons; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C-delta; Protein Multimerization; Rats; Rats, Wistar; Signal Transduction; Sphingosine; Thiazoles | 2011 |
Evaluation of cell cycle arrest in estrogen responsive MCF-7 breast cancer cells: pitfalls of the MTS assay.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Count; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colorimetry; Culture Media, Serum-Free; Deoxyuridine; DNA; Drug Design; Estradiol; Estrogens; Fingolimod Hydrochloride; Fluorescent Dyes; Fulvestrant; Humans; Isopropyl Thiogalactoside; Membrane Potential, Mitochondrial; Mitochondria; Propylene Glycols; Reproducibility of Results; Sphingosine; Tetrazolium Salts; Thiazoles; Tumor Suppressor Protein p14ARF | 2011 |
Endogenous sphingosine 1-phosphate regulates spontaneous glutamate release from mossy fiber terminals via S1P(3) receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Enzyme Inhibitors; Estrenes; Excitatory Postsynaptic Potentials; Glutamic Acid; Indoles; Lysophospholipids; Male; Maleimides; Mossy Fibers, Hippocampal; Neurons; Pyrrolidinones; Rats; Rats, Wistar; Receptors, Lysosphingolipid; Sphingosine; Suramin; Thiazoles | 2011 |
Targeting sphingosine kinase-1 to inhibit melanoma.
Topics: Animals; Apoptosis; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin D1; Down-Regulation; Fibroblasts; G1 Phase Cell Cycle Checkpoints; Humans; Lysophospholipids; Melanocytes; Melanoma; Mice; Molecular Targeted Therapy; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Resting Phase, Cell Cycle; RNA, Small Interfering; Skin Neoplasms; Sphingosine; Staurosporine; Thiazoles; Up-Regulation; Xenograft Model Antitumor Assays | 2012 |
The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism.
Topics: Androgen Receptor Antagonists; Antineoplastic Agents; Cell Line, Tumor; Down-Regulation; Enzyme Inhibitors; Fingolimod Hydrochloride; Free Radical Scavengers; Humans; Isoenzymes; Male; Neoplasm Proteins; Oxidative Stress; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Prostate-Specific Antigen; Prostatic Neoplasms; Protein Processing, Post-Translational; Protein Stability; Receptors, Androgen; RNA, Messenger; Sphingosine; Thiazoles | 2013 |
Sphingosine 1-phosphate (S1P) receptor agonists mediate pro-fibrotic responses in normal human lung fibroblasts via S1P2 and S1P3 receptors and Smad-independent signaling.
Topics: Actins; Animals; CHO Cells; Cricetinae; Cricetulus; Down-Regulation; Extracellular Matrix; Humans; Lung; Lysophospholipids; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myofibroblasts; Organophosphates; Oxadiazoles; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pulmonary Fibrosis; Receptors, Lysosphingolipid; Signal Transduction; Smad2 Protein; Smad3 Protein; Sphingosine; Thiazoles; Thiophenes; Transforming Growth Factor beta1 | 2013 |
Sphingosine kinase-1 inhibition protects primary rat hepatocytes against bile salt-induced apoptosis.
Topics: Animals; Apoptosis; Bile Acids and Salts; Blotting, Western; Caspase 3; Cells, Cultured; Detergents; Gastrointestinal Agents; Glycochenodeoxycholic Acid; Hepatocytes; Lysophospholipids; Male; Phosphotransferases (Alcohol Group Acceptor); Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Receptors, Lysosphingolipid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sphingosine; Thiazoles | 2013 |
Increased killing of SCCVII squamous cell carcinoma cells after the combination of Pc 4 photodynamic therapy and dasatinib is associated with enhanced caspase-3 activity and ceramide synthase 1 upregulation.
Topics: Abdominal Neoplasms; Acid Ceramidase; Amino Acid Chloromethyl Ketones; Animals; Annexin A5; Apoptosis; Carcinoma, Squamous Cell; Caspase 3; Caspase 9; Cell Line, Tumor; Ceramides; Dasatinib; Enzyme Activation; Head and Neck Neoplasms; Indoles; Mice; Mice, Inbred C3H; Mitochondria; Oxidoreductases; Photochemotherapy; Propidium; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; RNA, Messenger; Sphingosine; Thiazoles | 2013 |
Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: The role of sphingosine 1-phosphate receptor
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Nucleus; CSK Tyrosine-Protein Kinase; Female; Fingolimod Hydrochloride; Humans; Lysophospholipids; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Estrogen; Receptors, Lysosphingolipid; RNA Interference; RNA, Small Interfering; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; src-Family Kinases; Thiazoles; Tyrosine | 2014 |
Sphingosine-1-phosphate (S1P) displays sustained S1P1 receptor agonism and signaling through S1P lyase-dependent receptor recycling.
Topics: Arrestins; Autoimmune Diseases; beta-Arrestins; Cell Line, Tumor; GTP-Binding Protein alpha Subunits, Gi-Go; HeLa Cells; Human Umbilical Vein Endothelial Cells; Humans; Lysophospholipids; Membrane Proteins; Phosphoric Monoester Hydrolases; Protein Transport; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; T-Lymphocytes; Thiazoles | 2014 |
The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1.
Topics: Anilides; Animals; Antineoplastic Agents, Phytogenic; Cytokines; Enzyme Activation; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Indans; Lysophospholipids; Male; Neuralgia; Organophosphonates; Oxadiazoles; Paclitaxel; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Thiazoles; Thiophenes | 2014 |
Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Blotting, Western; Cell Line, Tumor; Enzyme Inhibitors; Fingolimod Hydrochloride; Humans; Microscopy, Electron, Transmission; Phosphotransferases (Alcohol Group Acceptor); Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Propylene Glycols; Sphingosine; Thiazoles; Unfolded Protein Response | 2014 |
SKI-II--a sphingosine kinase 1 inhibitor--exacerbates atherosclerosis in low-density lipoprotein receptor-deficient (LDL-R-/-) mice on high cholesterol diet.
Topics: Animals; Aorta, Thoracic; Aortic Diseases; Atherosclerosis; Biomarkers; Cholesterol, Dietary; Cholesterol, HDL; Diet, Western; Disease Models, Animal; Enzyme Inhibitors; Female; Hypercholesterolemia; Intercellular Adhesion Molecule-1; Lysophospholipids; Mice, Knockout; Phosphotransferases (Alcohol Group Acceptor); Receptors, LDL; Risk Factors; Sphingosine; Thiazoles; Time Factors; Triglycerides; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2015 |
Sphingosine kinase inhibition ameliorates chronic hypoperfusion-induced white matter lesions.
Topics: Animals; Brain; Carotid Artery Diseases; Cells, Cultured; Chronic Disease; Enzyme Inhibitors; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Phosphotransferases (Alcohol Group Acceptor); Rats; Rats, Sprague-Dawley; Sphingosine; Thiazoles; White Matter | 2016 |
Elevated intrathymic sphingosine-1-phosphate promotes thymus involution during sepsis.
Topics: Aminophenols; Animals; Apoptosis; Atrophy; Cecum; Disease Models, Animal; Interleukin-6; Lymphocytosis; Lymphopenia; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Phosphotransferases (Alcohol Group Acceptor); Receptors, Lysosphingolipid; Sepsis; Sphingosine; Thiazoles; Thymocytes; Thymus Gland | 2017 |
Modulation of sphingosine 1-phosphate (S1P) attenuates spatial learning and memory impairments in the valproic acid rat model of autism.
Topics: Analysis of Variance; Animals; Apoptosis; Autistic Disorder; Autophagy; Biomarkers; Disease Models, Animal; Hippocampus; Humans; Lysophospholipids; Male; Memory Disorders; Neurons; Phosphotransferases (Alcohol Group Acceptor); Rats; Rats, Wistar; Signal Transduction; Spatial Learning; Sphingosine; Thiazoles; Valproic Acid | 2018 |
Transient inhibition of sphingosine kinases confers protection to influenza A virus infected mice.
Topics: A549 Cells; Adamantane; Administration, Oral; Amino Alcohols; Aminophenols; Animals; Cell Line; Disease Models, Animal; Female; Gene Knockdown Techniques; HEK293 Cells; Humans; Influenza A virus; Mice; Mice, Inbred C57BL; Orthomyxoviridae Infections; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Isoforms; Pyridines; RNA, Small Interfering; Sphingosine; Thiazoles; Virus Replication | 2018 |