Compounds > thiazoles
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thiazoles and sphingosine kinase

thiazoles has been researched along with sphingosine kinase in 45 studies

Research

Studies (45)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's12 (26.67)29.6817
2010's33 (73.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bielawski, J; Dbaibo, GS; Gillanders, WE; Hannun, YA; Johnson, KR; Kozhaya, L; Obeid, LM; Osta, W; Taha, TA1
Coelho, RP; Goparaju, SK; Jolly, PS; Maceyka, M; Saini, HS; Sato-Bigbee, C; Spiegel, S1
Bergelin, N; Blom, T; Slotte, JP; Törnquist, K1
French, KJ; Keller, SN; Smith, CD; Upson, JJ; Yun, JK; Zhuang, Y1
Auzenne, E; Evans, R; Farquhar, D; Ghosh, SC; Hail, N; Klostergaard, J; Leroux, ME; McDonnell, T; Spohn, W1
Chen, S; Sun, J; Yan, G; You, B1
Jahangeer, S; Kotani, Y; Kuramoto, E; Nakamura, S; Nishimura, Y; Nishiuma, T; Okada, T1
Deitch, EA; Feketeova, E; Haskó, G; Hauser, CJ; Kannan, KB; Lee, C; Nemeth, Z; Xu, DZ1
Deliliers, GL; Ghidoni, R; Onida, F; Radaelli, F; Ricci, C; Saporiti, G; Servida, F; Todoerti, K1
Baumruker, T; Billich, A; Reuschel, R; Urtz, N1
Bektas, M; Bigner, DD; Friedman, HS; Johnson, SP; Poe, WE1
Baur, F; Fozard, JR; Trifilieff, A1
Hauser, CJ; Itagaki, K; Zhang, Q1
Huwiler, A; Pfeilschifter, J; Ren, S; Xin, C1
Chinn, SB; Hochstim, C; Masood, R; Schorn, VJ; Sinha, UK; Zhu, S1
Berdyshev, E; Leclercq, T; Lim, KG; Long, JS; Loveridge, C; Natarajan, V; Pitson, SM; Pyne, NJ; Pyne, S; Tate, RJ; Tonelli, F1
Chiba, Y; Misawa, M; Sakai, H; Takeuchi, H1
Highkin, MK; Lamarr, WA; Masferrer, JL; Munie, GE; Nagiec, MM; Nemirovskiy, OV; Rains, JW; Yates, MP1
Antoon, JW; Ashe, HB; Beckman, BS; Bratton, MR; Burow, ME; Meacham, WD; Rhodes, LV; Slaughter, EM; Wiese, TE1
Avcu, F; Baran, Y; Gencer, EB; Ural, AU1
Kanno, T; Nishizaki, T1
Fox, TE; Gowda, R; Hengst, J; Madhunapantula, SV; Robertson, GP; Yun, JK1
Antoon, JW; Beckman, BS; Burow, ME; White, MD1
Antoon, JW; Beckman, BS; Burow, ME; Driver, JL; White, MD1
Alossaimi, M; Bittman, R; Chan, E; Pyne, NJ; Pyne, S; Tate, RJ; Tonelli, F; Watson, DG; Williamson, L1
Chen, Y; He, H; Shao, R; Yu, D; Zhang, C; Zhang, H; Zhao, W1
Buist-Homan, M; Combettes, L; de Boer, JF; Faber, KN; Karimian, G; Klappe, K; Kok, JW; Moshage, H; Schmidt, M; Tietge, UJ; Tordjmann, T1
He, HW; Shao, RG; Zhang, CX1
Baxter, RC; de Silva, HC; Lin, MZ; Martin, JL; Scott, CD1
Baranowski, M; Chabowski, A; Górski, J; Mikłosz, A; Łukaszuk, B1
Bittman, R; Ohotski, J; Pyne, NJ; Pyne, S; Rosen, H1
Barnes, PJ; Curtis, JM; Ito, K; Kimura, G; Kizawa, Y; Mercado, N; Moses, A; Ueda, K; Xiong, Y1
Gong, YY; He, HW; Liu, H; Shao, RG; Zhang, CX1
Beak, DJ; Bertaina, A; Bittman, R; Chiarini, F; Evangelisti, C; Falconi, M; Locatelli, F; Martelli, AM; McCubrey, JA; Melchionda, F; Pession, A; Pyne, NJ; Pyne, S; Teti, G1
Brockhoff, G; Doescher, J; Haug, A; Mißlbeck, M; Pickhard, A; Piontek, G; Reiter, R; Rudelius, M; Schiefler, C; Schuettler, D1
Clark, K; Ozanne, J; Prescott, AR1
Li, PH; Pei, DS; Wu, JX; Zheng, JN1
Burkhardt, R; Ceglarek, U; Nofer, JR; Potì, F; Simoni, M1
Bae, DS; Cho, YJ; Choi, CH; Choi, JJ; Kim, BG; Kim, HS; Kim, TJ; Lee, JW; Lee, YY; Ryu, JY; Song, SY; Yoon, G1
Aurelio, L; Creek, DJ; Davies, L; Flynn, BL; Furic, L; Oliver, V; Pitman, MR; Pitson, SM; Rebello, RJ; Scullino, CV; Sexton, A1
Arai, K; Herr, DR; Lai, MK; Torta, F; Wenk, MR; Wong, PT; Yang, Y1
McNaughton, M; Pitman, M; Pitson, SM; Pyne, NJ; Pyne, S1
Angioni, C; Brüne, B; Ferreirós, N; Giegerich, AK; Knape, T; Kuchler, L; Schmidt, MV; Sha, LK; von Knethen, A; Weigert, A1
Cao, Y; Gao, J; Hao, Y; Sun, C; Wang, J; Wu, H; Wu, L; Xia, W; Zhang, Q1
Hahm, B; Seo, YJ; Studstill, CJ; Vijayan, M; Wolf, JJ; Xia, C1

Reviews

1 review(s) available for thiazoles and sphingosine kinase

ArticleYear
[Sphingosine kinase 1 and tumor].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2013, Volume: 48, Issue:7

    Topics: Amino Alcohols; Animals; Apoptosis; Cell Movement; Cell Proliferation; Ceramides; Enzyme Activation; Enzyme Inhibitors; Humans; Lysophospholipids; Neoplasms; Neovascularization, Pathologic; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Sphingosine; Thiazoles

2013

Other Studies

44 other study(ies) available for thiazoles and sphingosine kinase

ArticleYear
Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53.
    The Journal of biological chemistry, 2004, May-07, Volume: 279, Issue:19

    Topics: Apoptosis; Blotting, Western; Cell Division; Cell Line, Tumor; Cell Survival; Coloring Agents; Dactinomycin; DNA Damage; Dose-Response Relationship, Drug; Down-Regulation; Doxorubicin; Endopeptidases; Enzyme Inhibitors; Etoposide; Gamma Rays; Humans; Mass Spectrometry; Models, Biological; Phosphotransferases (Alcohol Group Acceptor); Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Polymerase Chain Reaction; RNA Processing, Post-Transcriptional; RNA, Messenger; RNA, Small Interfering; Tetrazolium Salts; Thiazoles; Transcription, Genetic; Tumor Suppressor Protein p53; Up-Regulation

2004
Novel role of sphingosine kinase 1 as a mediator of neurotrophin-3 action in oligodendrocyte progenitors.
    Journal of neurochemistry, 2005, Volume: 95, Issue:5

    Topics: Animals; Animals, Newborn; Blotting, Western; Cell Membrane; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Drug Interactions; Gene Expression Regulation; In Situ Nick-End Labeling; Lysophospholipids; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Neurotrophin 3; Oligodendroglia; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Sphingosine; Stem Cells; Thiazoles; Thiazolidinediones; Thiones; Time Factors

2005
Sphingosine kinase regulates voltage operated calcium channels in GH4C1 rat pituitary cells.
    Cellular signalling, 2006, Volume: 18, Issue:9

    Topics: Animals; Calcium; Calcium Channels; Cell Line; Membrane Potentials; Molecular Structure; Patch-Clamp Techniques; Phosphotransferases (Alcohol Group Acceptor); Pituitary Gland; Rats; Sphingosine; Thiazoles

2006
Antitumor activity of sphingosine kinase inhibitors.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 318, Issue:2

    Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Female; Half-Life; Lysophospholipids; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Multidrug Resistance-Associated Proteins; Phosphotransferases (Alcohol Group Acceptor); Proto-Oncogene Proteins c-akt; Sphingosine; Thiazoles

2006
Sphingolipids and the sphingosine kinase inhibitor, SKI II, induce BCL-2-independent apoptosis in human prostatic adenocarcinoma cells.
    The Prostate, 2007, Nov-01, Volume: 67, Issue:15

    Topics: Adenocarcinoma; Apoptosis; Cell Line, Tumor; Cell Survival; Ceramides; Down-Regulation; Enzyme Inhibitors; Humans; Male; Phosphotransferases (Alcohol Group Acceptor); Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Sphingosine; Thiazoles

2007
Activation of sphingosine kinase-1 mediates induction of endothelial cell proliferation and angiogenesis by epoxyeicosatrienoic acids.
    Cardiovascular research, 2008, May-01, Volume: 78, Issue:2

    Topics: 8,11,14-Eicosatrienoic Acid; Cell Movement; Cell Proliferation; Cells, Cultured; Endothelial Cells; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Humans; Lysophospholipids; Neovascularization, Physiologic; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Small Interfering; Signal Transduction; Sphingosine; Thiazoles

2008
Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model.
    American journal of physiology. Lung cellular and molecular physiology, 2008, Volume: 294, Issue:6

    Topics: Administration, Inhalation; Aniline Compounds; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cells, Cultured; Chemokines, CC; Disease Models, Animal; Enzyme Inhibitors; Goblet Cells; Humans; Hyperplasia; Interleukins; Lysophospholipids; Mice; Mice, Inbred C57BL; Ovalbumin; Phosphotransferases (Alcohol Group Acceptor); Respiratory Mucosa; Sphingosine; Thiazoles

2008
Calcium entry inhibition during resuscitation from shock attenuates inflammatory lung injury.
    Shock (Augusta, Ga.), 2008, Volume: 30, Issue:1

    Topics: Aminophenols; Animals; Calcium; Calcium Channel Blockers; Capillary Permeability; CD11b Antigen; Disease Models, Animal; Humans; Lung; Male; Neutrophils; Nitrendipine; p38 Mitogen-Activated Protein Kinases; Phosphotransferases (Alcohol Group Acceptor); Pneumonia; Rats; Rats, Sprague-Dawley; Respiratory Burst; Shock, Hemorrhagic; Shock, Traumatic; Thiazoles

2008
In vitro anti-leukaemia activity of sphingosine kinase inhibitor.
    British journal of haematology, 2009, Volume: 144, Issue:3

    Topics: Apoptosis; Benzamides; Blast Crisis; Cell Cycle; Colony-Forming Units Assay; Dose-Response Relationship, Drug; Drug Synergism; Gene Expression; Humans; Imatinib Mesylate; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Phosphotransferases (Alcohol Group Acceptor); Piperazines; Protein Kinase Inhibitors; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Time Factors

2009
Sphingosine kinase 1 is essential for proteinase-activated receptor-1 signalling in epithelial and endothelial cells.
    The international journal of biochemistry & cell biology, 2009, Volume: 41, Issue:7

    Topics: Animals; Cell Line, Tumor; Chemokine CCL2; Cyclooxygenase 2; Dinoprostone; Endothelial Cells; Enzyme Activation; Epithelial Cells; Gene Expression Regulation; Gene Silencing; Humans; Intercellular Adhesion Molecule-1; Interleukin-6; Interleukin-8; Mice; NF-kappa B; Phosphotransferases (Alcohol Group Acceptor); Receptor, PAR-1; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Thiazoles; Thrombin

2009
A sphingosine kinase inhibitor induces cell death in temozolomide resistant glioblastoma cells.
    Cancer chemotherapy and pharmacology, 2009, Volume: 64, Issue:5

    Topics: Aniline Compounds; Antineoplastic Agents, Alkylating; Apoptosis; Caspase 3; Cell Death; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Drug Resistance, Neoplasm; Enzyme Inhibitors; Flow Cytometry; Glioblastoma; Humans; Indicator Dilution Techniques; Oligonucleotide Array Sequence Analysis; Phosphotransferases (Alcohol Group Acceptor); Reverse Transcriptase Polymerase Chain Reaction; Temozolomide; Thiazoles

2009
Role of sphingosine-1-phosphate (S1P) and the S1P(2) receptor in allergen-induced, mast cell-dependent contraction of rat lung parenchymal strips.
    Naunyn-Schmiedeberg's archives of pharmacology, 2009, Volume: 380, Issue:4

    Topics: Acetates; Adenosine; Allergens; Animals; Bronchoconstriction; Cyclopropanes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Injections, Subcutaneous; Leukotriene Antagonists; Lung; Lysophospholipids; Male; Mast Cells; Methysergide; Ovalbumin; Phosphotransferases (Alcohol Group Acceptor); Pyrazoles; Pyridines; Quinolines; Rats; Rats, Inbred BN; Receptors, Lysosphingolipid; Serotonin; Serotonin Antagonists; Signal Transduction; Sphingosine; Sulfides; Thiazoles

2009
Sphingosine kinase inhibition alleviates endothelial permeability induced by thrombin and activated neutrophils.
    Shock (Augusta, Ga.), 2010, Volume: 33, Issue:4

    Topics: Aminophenols; Calcium; Capillary Permeability; Cells, Cultured; Computer Systems; Endothelial Cells; Gadolinium; Humans; Neutrophils; Nitrendipine; Phosphotransferases (Alcohol Group Acceptor); Sphingosine; Thapsigargin; Thiazoles; Thrombin

2010
A novel mode of action of the putative sphingosine kinase inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl) thiazole (SKI II): induction of lysosomal sphingosine kinase 1 degradation.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2010, Volume: 26, Issue:1

    Topics: Cathepsin B; Cell Line; Cycloheximide; Down-Regulation; Enzyme Inhibitors; Humans; Phosphotransferases (Alcohol Group Acceptor); Protein Synthesis Inhibitors; RNA, Messenger; Thiazoles; Transforming Growth Factor beta

2010
Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition.
    Head & neck, 2011, Volume: 33, Issue:2

    Topics: Animals; Apoptosis; Blotting, Western; Carcinoma; Carcinoma, Squamous Cell; Disease Models, Animal; Enzyme Inhibitors; Head and Neck Neoplasms; Humans; Immunohistochemistry; In Vitro Techniques; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Squamous Cell; Phosphotransferases (Alcohol Group Acceptor); Polymerase Chain Reaction; Radiation Tolerance; Squamous Cell Carcinoma of Head and Neck; Thiazoles; Treatment Outcome

2011
The sphingosine kinase 1 inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells.
    The Journal of biological chemistry, 2010, Dec-10, Volume: 285, Issue:50

    Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Densitometry; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Male; Phosphotransferases (Alcohol Group Acceptor); Prostatic Neoplasms; Proteasome Endopeptidase Complex; Thiazoles; Ubiquitin

2010
SKI-II, an inhibitor of sphingosine kinase, ameliorates antigen-induced bronchial smooth muscle hyperresponsiveness, but not airway inflammation, in mice.
    Journal of pharmacological sciences, 2010, Volume: 114, Issue:3

    Topics: Animals; Antigens; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Immunoglobulin E; Interleukin-13; Interleukin-4; Lysophospholipids; Male; Mice; Mice, Inbred BALB C; Muscle, Smooth; Phosphotransferases (Alcohol Group Acceptor); Sphingosine; Thiazoles

2010
High-throughput screening assay for sphingosine kinase inhibitors in whole blood using RapidFire® mass spectrometry.
    Journal of biomolecular screening, 2011, Volume: 16, Issue:2

    Topics: Aminophenols; Dose-Response Relationship, Drug; Enzyme Inhibitors; High-Throughput Screening Assays; Humans; Kinetics; Lysophospholipids; Mass Spectrometry; Phosphotransferases (Alcohol Group Acceptor); Signal Transduction; Sphingosine; Thiazoles

2011
Pharmacological inhibition of sphingosine kinase isoforms alters estrogen receptor signaling in human breast cancer.
    Journal of molecular endocrinology, 2011, Volume: 46, Issue:3

    Topics: Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Computer Simulation; Estrogen Receptor alpha; Humans; Isoenzymes; Mass Spectrometry; Phosphotransferases (Alcohol Group Acceptor); Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Thiazoles

2011
A novel mechanism of dasatinib-induced apoptosis in chronic myeloid leukemia; ceramide synthase and ceramide clearance genes.
    Annals of hematology, 2011, Volume: 90, Issue:11

    Topics: Apoptosis; Caspase 3; Cell Line; Ceramides; Dasatinib; Dose-Response Relationship, Drug; Glucosyltransferases; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Membrane Potential, Mitochondrial; Oxidoreductases; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase Inhibitors; Pyrimidines; Thiazoles

2011
Sphingosine induces apoptosis in hippocampal neurons and astrocytes by activating caspase-3/-9 via a mitochondrial pathway linked to SDK/14-3-3 protein/Bax/cytochrome c.
    Journal of cellular physiology, 2011, Volume: 226, Issue:9

    Topics: 14-3-3 Proteins; Animals; Apoptosis; Astrocytes; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Cells, Cultured; Cytochromes c; Enzyme Activation; Hippocampus; Intracellular Space; Membrane Potential, Mitochondrial; Mitochondria; Neurons; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C-delta; Protein Multimerization; Rats; Rats, Wistar; Signal Transduction; Sphingosine; Thiazoles

2011
Targeting sphingosine kinase-1 to inhibit melanoma.
    Pigment cell & melanoma research, 2012, Volume: 25, Issue:2

    Topics: Animals; Apoptosis; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin D1; Down-Regulation; Fibroblasts; G1 Phase Cell Cycle Checkpoints; Humans; Lysophospholipids; Melanocytes; Melanoma; Mice; Molecular Targeted Therapy; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Resting Phase, Cell Cycle; RNA, Small Interfering; Skin Neoplasms; Sphingosine; Staurosporine; Thiazoles; Up-Regulation; Xenograft Model Antitumor Assays

2012
Dual inhibition of sphingosine kinase isoforms ablates TNF-induced drug resistance.
    Oncology reports, 2012, Volume: 27, Issue:6

    Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Isoenzymes; NF-kappa B; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Signal Transduction; Thiazoles; Transcription Factor RelA; Tumor Necrosis Factor-alpha

2012
Sphingosine kinase isoforms as a therapeutic target in endocrine therapy resistant luminal and basal-A breast cancer.
    Experimental biology and medicine (Maywood, N.J.), 2012, Volume: 237, Issue:7

    Topics: Adamantane; Aminophenols; Animals; Antineoplastic Agents, Hormonal; Base Sequence; Breast Neoplasms; Cell Line, Tumor; DNA Primers; Drug Resistance, Neoplasm; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Humans; Isoenzymes; Mice; Mice, Nude; Mice, SCID; Phosphotransferases (Alcohol Group Acceptor); Pyridines; Real-Time Polymerase Chain Reaction; Receptors, Estrogen; Thiazoles; Xenograft Model Antitumor Assays

2012
The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism.
    British journal of pharmacology, 2013, Volume: 168, Issue:6

    Topics: Androgen Receptor Antagonists; Antineoplastic Agents; Cell Line, Tumor; Down-Regulation; Enzyme Inhibitors; Fingolimod Hydrochloride; Free Radical Scavengers; Humans; Isoenzymes; Male; Neoplasm Proteins; Oxidative Stress; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Prostate-Specific Antigen; Prostatic Neoplasms; Protein Processing, Post-Translational; Protein Stability; Receptors, Androgen; RNA, Messenger; Sphingosine; Thiazoles

2013
The blockage of Ras/ERK pathway augments the sensitivity of SphK1 inhibitor SKI II in human hepatoma HepG2 cells.
    Biochemical and biophysical research communications, 2013, Apr-26, Volume: 434, Issue:1

    Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Drug Synergism; Hep G2 Cells; Humans; Liver Neoplasms; MAP Kinase Signaling System; Phosphotransferases (Alcohol Group Acceptor); ras Proteins; Thiazoles

2013
Sphingosine kinase-1 inhibition protects primary rat hepatocytes against bile salt-induced apoptosis.
    Biochimica et biophysica acta, 2013, Volume: 1832, Issue:12

    Topics: Animals; Apoptosis; Bile Acids and Salts; Blotting, Western; Caspase 3; Cells, Cultured; Detergents; Gastrointestinal Agents; Glycochenodeoxycholic Acid; Hepatocytes; Lysophospholipids; Male; Phosphotransferases (Alcohol Group Acceptor); Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Receptors, Lysosphingolipid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sphingosine; Thiazoles

2013
Inhibition of insulin-like growth factor-binding protein-3 signaling through sphingosine kinase-1 sensitizes triple-negative breast cancer cells to EGF receptor blockade.
    Molecular cancer therapeutics, 2014, Volume: 13, Issue:2

    Topics: Animals; Blotting, Western; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Female; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Insulin-Like Growth Factor Binding Protein 3; MCF-7 Cells; Mice, Inbred BALB C; Mice, Nude; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase Inhibitors; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; Thiazoles; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays

2014
Effects of inhibition of serine palmitoyltransferase (SPT) and sphingosine kinase 1 (SphK1) on palmitate induced insulin resistance in L6 myotubes.
    PloS one, 2013, Volume: 8, Issue:12

    Topics: Analysis of Variance; Animals; Blotting, Western; Chromatography, High Pressure Liquid; Deoxyglucose; Fatty Acids, Monounsaturated; Insulin Resistance; Muscle Fibers, Skeletal; Palmitates; Phosphotransferases (Alcohol Group Acceptor); Rats; Serine C-Palmitoyltransferase; Thiazoles

2013
Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: The role of sphingosine 1-phosphate receptor
    Cellular signalling, 2014, Volume: 26, Issue:5

    Topics: Breast Neoplasms; Cell Line, Tumor; Cell Nucleus; CSK Tyrosine-Protein Kinase; Female; Fingolimod Hydrochloride; Humans; Lysophospholipids; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Estrogen; Receptors, Lysosphingolipid; RNA Interference; RNA, Small Interfering; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; src-Family Kinases; Thiazoles; Tyrosine

2014
Activation of transcription factor Nrf2 signalling by the sphingosine kinase inhibitor SKI-II is mediated by the formation of Keap1 dimers.
    PloS one, 2014, Volume: 9, Issue:2

    Topics: Animals; Cell Line; Cells, Cultured; Humans; Intracellular Signaling Peptides and Proteins; Kelch-Like ECH-Associated Protein 1; Lung; Male; Mice; NF-E2-Related Factor 2; Oxidative Stress; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase Inhibitors; Protein Multimerization; Respiratory Mucosa; Signal Transduction; Smoking; Thiazoles

2014
[Inhibitions of SphK1 inhibitor SKI II on cell cycle progression and cell invasion of hepatoma HepG2 cells].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2014, Volume: 49, Issue:2

    Topics: CDC2 Protein Kinase; Cell Movement; Cell Survival; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; G1 Phase; Hep G2 Cells; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Phosphotransferases (Alcohol Group Acceptor); Thiazoles

2014
Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics.
    Oncotarget, 2014, Sep-15, Volume: 5, Issue:17

    Topics: Antineoplastic Agents; Apoptosis; Autophagy; Blotting, Western; Cell Line, Tumor; Enzyme Inhibitors; Fingolimod Hydrochloride; Humans; Microscopy, Electron, Transmission; Phosphotransferases (Alcohol Group Acceptor); Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Propylene Glycols; Sphingosine; Thiazoles; Unfolded Protein Response

2014
Inhibition of SphK1 reduces radiation-induced migration and enhances sensitivity to cetuximab treatment by affecting the EGFR / SphK1 crosstalk.
    Oncotarget, 2014, Oct-30, Volume: 5, Issue:20

    Topics: Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cetuximab; Disease Progression; ErbB Receptors; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Paraffin Embedding; Phosphotransferases (Alcohol Group Acceptor); Receptor Cross-Talk; Signal Transduction; Squamous Cell Carcinoma of Head and Neck; Thiazoles

2014
The clinically approved drugs dasatinib and bosutinib induce anti-inflammatory macrophages by inhibiting the salt-inducible kinases.
    The Biochemical journal, 2015, Jan-15, Volume: 465, Issue:2

    Topics: Aniline Compounds; Animals; Arginase; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Cytokines; Dasatinib; Immunity, Innate; Macrophages; Mice; Nitriles; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrimidines; Quinolines; Thiazoles; Transcription Factors; Tumor Necrosis Factor Ligand Superfamily Member 14

2015
A sphingosine kinase-1 inhibitor, SKI-II, induces growth inhibition and apoptosis in human gastric cancer cells.
    Asian Pacific journal of cancer prevention : APJCP, 2014, Volume: 15, Issue:23

    Topics: Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Cell Proliferation; Cell Survival; Humans; NF-kappa B; Phosphotransferases (Alcohol Group Acceptor); Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins c-bcl-2; Stomach Neoplasms; Thiazoles

2014
SKI-II--a sphingosine kinase 1 inhibitor--exacerbates atherosclerosis in low-density lipoprotein receptor-deficient (LDL-R-/-) mice on high cholesterol diet.
    Atherosclerosis, 2015, Volume: 240, Issue:1

    Topics: Animals; Aorta, Thoracic; Aortic Diseases; Atherosclerosis; Biomarkers; Cholesterol, Dietary; Cholesterol, HDL; Diet, Western; Disease Models, Animal; Enzyme Inhibitors; Female; Hypercholesterolemia; Intercellular Adhesion Molecule-1; Lysophospholipids; Mice, Knockout; Phosphotransferases (Alcohol Group Acceptor); Receptors, LDL; Risk Factors; Sphingosine; Thiazoles; Time Factors; Triglycerides; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1

2015
Sphingosine kinase 1 is a reliable prognostic factor and a novel therapeutic target for uterine cervical cancer.
    Oncotarget, 2015, Sep-29, Volume: 6, Issue:29

    Topics: Adult; Animals; Apoptosis; Biomarkers, Tumor; Cell Line, Tumor; Cell Survival; Disease Progression; Disease-Free Survival; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Fingolimod Hydrochloride; Formaldehyde; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Immunohistochemistry; Lymphatic Metastasis; Mice; Mice, Inbred BALB C; Middle Aged; Neoplasm Transplantation; Paraffin Embedding; Phosphotransferases (Alcohol Group Acceptor); Prognosis; Thiazoles; Uterine Cervical Neoplasms

2015
From Sphingosine Kinase to Dihydroceramide Desaturase: A Structure-Activity Relationship (SAR) Study of the Enzyme Inhibitory and Anticancer Activity of 4-((4-(4-Chlorophenyl)thiazol-2-yl)amino)phenol (SKI-II).
    Journal of medicinal chemistry, 2016, Feb-11, Volume: 59, Issue:3

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Molecular Structure; Oxidoreductases; Phosphotransferases (Alcohol Group Acceptor); Structure-Activity Relationship; Thiazoles

2016
Sphingosine kinase inhibition ameliorates chronic hypoperfusion-induced white matter lesions.
    Neurochemistry international, 2016, Volume: 94

    Topics: Animals; Brain; Carotid Artery Diseases; Cells, Cultured; Chronic Disease; Enzyme Inhibitors; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Phosphotransferases (Alcohol Group Acceptor); Rats; Rats, Sprague-Dawley; Sphingosine; Thiazoles; White Matter

2016
Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells.
    Oncotarget, 2016, Mar-29, Volume: 7, Issue:13

    Topics: Adamantane; Antineoplastic Agents; Cell Cycle Checkpoints; Cell Line, Tumor; Humans; Male; Oxidoreductases; Phosphotransferases (Alcohol Group Acceptor); Prostatic Neoplasms, Castration-Resistant; Proteasome Endopeptidase Complex; Pyridines; Thiazoles

2016
Elevated intrathymic sphingosine-1-phosphate promotes thymus involution during sepsis.
    Molecular immunology, 2017, Volume: 90

    Topics: Aminophenols; Animals; Apoptosis; Atrophy; Cecum; Disease Models, Animal; Interleukin-6; Lymphocytosis; Lymphopenia; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Phosphotransferases (Alcohol Group Acceptor); Receptors, Lysosphingolipid; Sepsis; Sphingosine; Thiazoles; Thymocytes; Thymus Gland

2017
Modulation of sphingosine 1-phosphate (S1P) attenuates spatial learning and memory impairments in the valproic acid rat model of autism.
    Psychopharmacology, 2018, Volume: 235, Issue:3

    Topics: Analysis of Variance; Animals; Apoptosis; Autistic Disorder; Autophagy; Biomarkers; Disease Models, Animal; Hippocampus; Humans; Lysophospholipids; Male; Memory Disorders; Neurons; Phosphotransferases (Alcohol Group Acceptor); Rats; Rats, Wistar; Signal Transduction; Spatial Learning; Sphingosine; Thiazoles; Valproic Acid

2018
Transient inhibition of sphingosine kinases confers protection to influenza A virus infected mice.
    Antiviral research, 2018, Volume: 158

    Topics: A549 Cells; Adamantane; Administration, Oral; Amino Alcohols; Aminophenols; Animals; Cell Line; Disease Models, Animal; Female; Gene Knockdown Techniques; HEK293 Cells; Humans; Influenza A virus; Mice; Mice, Inbred C57BL; Orthomyxoviridae Infections; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Isoforms; Pyridines; RNA, Small Interfering; Sphingosine; Thiazoles; Virus Replication

2018