thiazoles has been researched along with sk&f 86002 in 68 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (17.65) | 18.7374 |
| 1990's | 30 (44.12) | 18.2507 |
| 2000's | 18 (26.47) | 29.6817 |
| 2010's | 8 (11.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Eliakim, R; Karmeli, F; Ligumsky, M; Rachmilewitz, D; Simon, P | 1 |
| Haynes, WL; Hirakata, A; Proia, AD | 1 |
| Crowe, N; Moore, JN; Morris, DD | 1 |
| Griswold, DE; Hillegass, LM; Webb, EF | 1 |
| Howard, MO; Newton, JF; Qualls, CW; Schwartz, LW; Ventre, JR; Yodis, LA | 1 |
| Bartus, JO; Esser, KM; Slivjak, MJ; Smith, EF | 1 |
| Quinlan, MF; Schwartz, LW; Turner, CR; Wheeldon, EB | 1 |
| Barton, BE; James, LC | 1 |
| Anderson, DC; Hughes, H; Mitchell, JR; Shappell, SB; Smith, CW; Taylor, AA | 1 |
| Badger, AM; Hanna, N; Olivera, D; Talmadge, JE | 1 |
| Bender, PE; Griswold, DE; Hanna, N; Hillegass, L; Hoffstein, S; Marshall, PJ; Webb, EF | 1 |
| Laydon, JT; Lee, JC; Rebar, L | 1 |
| Griswold, DE; Hanna, N; Lee, JC; Votta, B | 2 |
| DiMartino, MJ; Gleason, JG; Godfrey, R; Griswold, DE; Hanna, N; Marshall, PJ; Newton, J; Poste, G; Sarau, HM; Webb, EF | 1 |
| Berkowitz, BA; DiMartino, MJ; Griswold, DE; Hanna, N; Poste, G | 1 |
| Griswold, DE; Hanna, N; Schwartz, L; Webb, E | 1 |
| DiMartino, MJ; Griswold, DE; Hanna, N; Hillegass, LM; Meunier, PC | 1 |
| Campbell, GK; DiMartino, MJ; Hanna, N; Wolff, CE | 1 |
| Manson, JM; Schwartz, LW; Walker, RF | 1 |
| Manson, JM; Newton, JF; Schwartz, LW; Torphy, TJ; Walker, RF | 1 |
| Kassis, S; Lee, JC; Prabhakar, U | 1 |
| Connelly, P; Cronan, M; Dean, D; Gabel, CA; Perregaux, DG | 1 |
| Dunnington, D; Hand, A; Prichett, W; Sheilds, J | 1 |
| Lipshutz, D; Prabhakar, U; Truneh, A | 1 |
| Breton, J; Griswold, DE; Marshall, PJ; Torphy, TJ; Webb, EF; White, JR | 1 |
| Adams, JL; Breton, JJ; Esser, KM; Griswold, DE; Hillegass, LM | 1 |
| Chin, J; Kostura, MJ | 1 |
| Badger, AM; Hillegass, L; Laydon, JT; Lee, JC; Olivera, DL | 1 |
| Dunnington, D; Hand, A; Laydon, J; Lee, J; McDonnell, P; Young, P | 1 |
| Fann, PC; Goode, RL; Hartman, DF | 1 |
| Carlson, RP; Hartman, DA; Ochalski, SJ | 1 |
| Albrightson, CR; Bresnahan, BA; Griswold, D; Lianos, EA; Pan, CG | 1 |
| Clayton, MK; Cooley, AJ; Darien, BJ; Hart, AP; Kruse-Elliott, KT; MacWilliams, PS; Schram, BR; Triplett, EA | 1 |
| Avdi, NJ; Gerwins, P; Johnson, GL; Knall, C; Nick, JA; Worthen, GS; Young, SK | 1 |
| Baillargeon, J; Cleland, LG; James, MJ; Lee, JC; Pouliot, M | 1 |
| Fanger, GR; Gelfand, EW; Gerwins, P; Hamelmann, E; Ishizuka, T; Johnson, GL; Oshiba, A; Terada, N | 1 |
| Anson, JG; Craig, FF; Dickson, MC; Houston, JG; Kendrick, MK; Su, S; Thomas, N; Vivier, RG; Williamson, NM | 1 |
| Blanque, R; Cottereaux, C; Gardner, CR | 1 |
| Bratton, DL; Fadok, VA; Frasch, SC; Henson, PM; Nick, JA; Worthen, GS | 1 |
| Car, BD; Meunier, PC; Schnyder, B | 1 |
| Abe, J; Berk, BC; Han, J; Ishida, M; Kusuhara, M; Peterson, TE; Takahashi, E; Ulevitch, R | 1 |
| Adams, JL; Griswold, DE; Kumar, S; Lee, JC; Underwood, DC; Votta, BJ | 1 |
| Bais, C; Gutkind, JS; Mesri, EA; Montaner, S; Patel, V; Sodhi, A; Zohar, M | 1 |
| de Caestecker, MP; Watanabe, H; Yamada, Y | 1 |
| Cara, DC; Forster, M; Kaur, J; Kubes, P; McCafferty, DM | 1 |
| Cao, BZ; Jing, Q; Lei, ZB; Li, XY; Pei, G; Qin, YW; Zhang, Z | 1 |
| Alvi, SA; Bennett, PR; Brown, NL; Elder, MG; Sullivan, MH | 1 |
| Bloom, SE; Muscarella, DE | 1 |
| Kaur, J; Kubes, P; Woodman, RC | 1 |
| Blaschke, F; Bruemmer, D; Kintscher, U; Law, RE; Unger, T | 1 |
| Guinea Viniegra, J; Hernández Losa, J; Parada Cobo, C; Ramón y Cajal, S; Sánchez-Arevalo Lobo, VJ; Sánchez-Prieto, R | 1 |
| Bukhtiyarova, M; Casper, D; Springman, EB | 1 |
| Ramesh, G; Reeves, WB | 1 |
| Diller, DJ; Lin, TH; Metzger, A | 1 |
| Laufer, S; Wagner, G | 1 |
| Assmann, G; Feuerborn, R; Nofer, JR; Noll, C; Tepel, M | 1 |
| Comella, JX; Concannon, CG; Fernandez-Gomez, FJ; Galindo, MF; Gomez-Lazaro, M; Jordan, J; Llecha, N; Prehn, JH; Segura, MF | 1 |
| Baldwin, RM; Gray, DA; Lorimer, IA; Tang, MY; Tsirigotis, M | 1 |
| Jeppsson, B; Laschke, MW; Menger, MD; Mihaescu, A; Santén, S; Thorlacius, H; Wang, Y | 1 |
| Handa, N; Honda, K; Mikuni, J; Ogawa, N; Parker, LJ; Shirouzu, M; Tanaka, A; Taruya, S; Tomabechi, Y; Tsuganezawa, K; Yokoyama, S | 1 |
| Banerjee, A; Boyett, JM; Fisher, M; Fouladi, M; Goldman, S; Kun, L; Lulla, R; Onar-Thomas, A; Packer, RJ; Pollack, I; Rood, BR; Smith, C; Stewart, CF; Turner, DC; Wu, S; Young-Pouissant, T | 1 |
| Arutaki, M; Hanzawa, H; Mizukoshi, Y; Shimada, I; Takahashi, H; Takeuchi, K; Takizawa, T | 1 |
| Ambinder, RF; Bender Ignacio, RA; Dittmer, DP; Krown, SE; Lee, JY; Rudek, MA | 1 |
| Dai, HL; Gaung, XF; Hu, WY; Jiang, LH; Li, L; Xiao, ZC | 1 |
| Almstead, N; Babiak, J; Cao, L; Colacino, J; Dali, M; Davis, T; Elfring, G; Hirawat, S; Moon, YC; Northcutt, V; Peltz, SW; Riebling, P; Spiegel, R; Weetall, M | 1 |
| Clayton, AH; Khattab, M; Van Dongen, M; Wang, F | 1 |
| Almstead, NG; Arasu, T; Babiak, J; Branstrom, A; Cao, L; Cintron, K; Colacino, JM; Davis, TW; Du, J; Furia, B; Graci, JD; Hedrick, J; Hwang, S; Jacobson, A; Kim, MJ; Kong, R; Lennox, W; Li, W; Ma, J; Moon, YC; Peltz, SW; Petruska, J; Qi, H; Risher, N; Romfo, C; Sheedy, J; Trotta, C; Weetall, M; Yeh, S | 1 |
3 review(s) available for thiazoles and sk&f 86002
| Article | Year |
|---|---|
Inhibition of p38 MAP kinase as a therapeutic strategy.
Topics: Animals; Cytokines; Enzyme Inhibitors; Humans; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Substrate Specificity; Thiazoles | 2000 |
The discovery of novel chemotypes of p38 kinase inhibitors.
Topics: Anti-Inflammatory Agents; Crystallography, X-Ray; Drug Design; Drug Evaluation, Preclinical; Drug Industry; Enzyme Inhibitors; Imidazoles; Molecular Structure; p38 Mitogen-Activated Protein Kinases; Technology, Pharmaceutical; Thiazoles | 2005 |
Small molecular anti-cytokine agents.
Topics: ADAM Proteins; ADAM17 Protein; Animals; Caspase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytokines; Humans; Hydroxamic Acids; Imidazoles; Matrix Metalloproteinase Inhibitors; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridazines; Pyridines; Pyrimidines; Quinazolines; Structure-Activity Relationship; Succinates; Thiazoles; Tumor Necrosis Factor-alpha; Urea | 2006 |
4 trial(s) available for thiazoles and sk&f 86002
| Article | Year |
|---|---|
Pharmacologic and surgical enhancement of composite graft survival.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Ear Cartilage; Ear, External; Graft Survival; Humans; Imidazoles; Infant, Newborn; Methylprednisolone; Rabbits; Skin Transplantation; Thiazoles; Time Factors | 1993 |
Phase I and pharmacokinetic trial of PTC299 in pediatric patients with refractory or recurrent central nervous system tumors: a PBTC study.
Topics: Adolescent; Antineoplastic Agents; Central Nervous System Neoplasms; Child; Child, Preschool; Female; Humans; Hyponatremia; Imidazoles; Male; Neoplasm Recurrence, Local; Thiazoles; Treatment Outcome; Young Adult | 2015 |
Brief Report: A Phase 1b/Pharmacokinetic Trial of PTC299, a Novel PostTranscriptional VEGF Inhibitor, for AIDS-Related Kaposi's Sarcoma: AIDS Malignancy Consortium Trial 059.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; DNA, Viral; Enzyme Inhibitors; Herpesvirus 8, Human; Humans; Imidazoles; Interleukin-6; Male; Middle Aged; Sarcoma, Kaposi; Thiazoles; Vascular Endothelial Growth Factor A | 2016 |
Phase 1 Study of Safety, Tolerability, and Pharmacokinetics of PTC299, an Inhibitor of Stress-Regulated Protein Translation.
Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents; Area Under Curve; Biological Availability; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Imidazoles; Male; Middle Aged; Thiazoles; Vascular Endothelial Growth Factor A; Young Adult | 2016 |
61 other study(ies) available for thiazoles and sk&f 86002
| Article | Year |
|---|---|
Cytokines and platelet-activating factor in human inflamed colonic mucosa.
Topics: Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Anti-Idiotypic; Calcimycin; Colitis, Ulcerative; Colon; Crohn Disease; Humans; Imidazoles; Immunoglobulin E; Interleukin-1; Intestinal Mucosa; Mesalamine; Organ Culture Techniques; Platelet Activating Factor; Prednisolone; Sulfasalazine; Thiazoles | 1992 |
Inhibition of corneal neovascularization in the rat by SK&F 86002, a dual inhibitor of arachidonic acid metabolism.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cornea; Dose-Response Relationship, Drug; Imidazoles; Male; Neovascularization, Pathologic; Rats; Rats, Inbred Strains; Thiazoles | 1992 |
Reduced endotoxin-induced production of tumor necrosis factor activity by equine peritoneal macrophages exposed to the dual inhibitor of arachidonic acid metabolism, SK & F 86002.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Cells, Cultured; Female; Horses; Imidazoles; Lipopolysaccharides; Macrophages; Male; Peritoneal Cavity; Thiazoles; Tumor Necrosis Factor-alpha | 1992 |
Induction of plasma exudation and inflammatory cell infiltration by leukotriene C4 and leukotriene B4 in mouse peritonitis.
Topics: Animals; Ascites; Capillary Permeability; Chemotaxis, Leukocyte; Colchicine; Drug Interactions; Imidazoles; Inflammation; Injections, Intraperitoneal; Leukotriene B4; Male; Mice; Mice, Inbred BALB C; Neutrophils; Peritonitis; Pyrazoles; SRS-A; Thiazoles | 1991 |
Comparative biochemical and morphometric changes associated with induction of the hepatic mixed function oxidase system in the rat.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Hypertrophy; Imidazoles; Leukotriene B4; Liver; Male; Microscopy, Electron; Mixed Function Oxygenases; Organ Size; Organelles; Phenobarbital; Rats; Rats, Inbred Strains; Thiazoles | 1991 |
SK&F 86002 inhibits tumor necrosis factor formation and improves survival in endotoxemic rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Depression, Chemical; Endotoxins; Escherichia coli; Heart Rate; Hematocrit; Imidazoles; Leukocyte Count; Male; Platelet Count; Rats; Rats, Inbred Strains; Thiazoles; Tumor Necrosis Factor-alpha | 1991 |
Therapeutic intervention in a rat model of ARDS: I. Dual inhibition of arachidonic acid metabolism.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bronchoalveolar Lavage Fluid; Capillary Permeability; Disease Models, Animal; Erythrocyte Count; Escherichia coli; Hematocrit; Hemoglobins; Imidazoles; Leukocyte Count; Lipopolysaccharides; Lipoxygenase Inhibitors; Male; Methylprednisolone; Neutrophils; Platelet Count; Rats; Rats, Inbred Strains; Respiratory Distress Syndrome; Thiazoles | 1990 |
The effect of dual inhibitor, SK&F 86002, on helper T cell functions.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens; Dermatitis, Contact; Dinitrophenols; Imidazoles; In Vitro Techniques; Interleukin-1; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Mice; Mice, Inbred Strains; Serum Albumin, Bovine; T-Lymphocytes, Helper-Inducer; Thiazoles | 1990 |
Comparison of antioxidant and nonantioxidant lipoxygenase inhibitors on neutrophil function. Implications for pathogenesis of myocardial reperfusion injury.
Topics: Antigens, Differentiation; Antioxidants; Cell Aggregation; Cell Movement; Humans; Hydroxyquinolines; Imidazoles; Leukotriene B4; Lipoxygenase Inhibitors; Macrophage-1 Antigen; Masoprocol; Myocardial Reperfusion Injury; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Quinolines; Receptors, Leukocyte-Adhesion; Thiazoles | 1990 |
Protective effect of SK&F 86002, a novel dual inhibitor of arachidonic acid metabolism, in murine models of endotoxin shock: inhibition of tumor necrosis factor as a possible mechanism of action.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Dexamethasone; Disease Models, Animal; Galactosamine; Imidazoles; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Propionibacterium acnes; Shock, Septic; Thiazoles; Tumor Necrosis Factor-alpha | 1989 |
Inhibition of inflammatory cell infiltration by bicyclic imidazoles, SK&F 86002 and SK&F 104493.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemotaxis, Leukocyte; Cyclophosphamide; Dinoprostone; Ear Diseases; Edema; Eicosanoids; Imidazoles; Inflammation; Leukotriene B4; Male; Mice; Mice, Inbred BALB C; Neutrophils; Peritonitis; Pyridines; Thiazoles | 1989 |
Effect of SK&F 86002 on cytokine production by human monocytes.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biological Factors; Colony-Stimulating Factors; Culture Techniques; Cytokines; Humans; Imidazoles; Interferon Type I; Interleukin-2; Lipopolysaccharides; Monocytes; Thiazoles; Tumor Necrosis Factor-alpha | 1989 |
Inhibitory effect of SK&F 86002 on monocyte IL-1 production.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Imidazoles; In Vitro Techniques; Interleukin-1; Monocytes; SRS-A; Thiazoles | 1989 |
SK&F 86002: a structurally novel anti-inflammatory agent that inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid.
Topics: Animals; Anti-Inflammatory Agents; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Humans; Imidazoles; Inflammation; Leukocytes; Leukotriene B4; Lipoxygenase Inhibitors; Mice; Pyrazoles; Rats; SRS-A; Thiazoles | 1987 |
Pharmacologic characterization of the antiinflammatory properties of a new dual inhibitor of lipoxygenase and cyclooxygenase.
Topics: Administration, Oral; Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cyclooxygenase Inhibitors; Edema; Imidazoles; Lipoxygenase Inhibitors; Male; Rats; Rats, Inbred Lew; Thiazoles | 1987 |
Arachidonic acid-induced inflammation: inhibition by dual inhibitor of arachidonic acid metabolism, SK&F 86002.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Ibuprofen; Imidazoles; Inflammation; Male; Masoprocol; Mice; Mice, Inbred BALB C; Naproxen; Peritonitis; Piroxicam; Pyrazoles; Thiazoles | 1987 |
Effect of inhibitors of eicosanoid metabolism in murine collagen-induced arthritis.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Arthritis; Collagen; Dexamethasone; Ibuprofen; Imidazoles; Male; Mice; Mice, Inbred DBA; Pyrazoles; Serum Amyloid P-Component; Thiazoles | 1988 |
Inhibition of monocyte IL-1 production by the anti-inflammatory compound, SK&F 86002.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Humans; Imidazoles; In Vitro Techniques; Interleukin-1; Kinetics; Lipoxygenase Inhibitors; Monocytes; Thiazoles | 1988 |
Inhibition of experimental allergic encephalomyelitis by a new anti-inflammatory compound--SK&F 86002.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Encephalomyelitis, Autoimmune, Experimental; Imidazoles; Rats; Rats, Inbred Lew; Thiazoles | 1988 |
Ovarian effects of an anti-inflammatory-immunomodulatory drug in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Eating; Estrus; Female; Gonadal Steroid Hormones; Imidazoles; Organ Size; Ovary; Rats; Thiazoles; Uterus | 1988 |
Ovarian effects of SK&F 86002-A2 in the rat: site of action.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Estradiol; Female; Hypophysectomy; Imidazoles; Injections, Subcutaneous; Luteinizing Hormone; Ovarian Follicle; Ovary; Ovulation; Rats; Rats, Inbred Strains; Thiazoles | 1988 |
Inhibition of interleukin-1 (IL-1) and tumor necrosis factor (TNF) production by pyridinyl imidazole compounds is independent of cAMP elevating mechanisms.
Topics: 1-Methyl-3-isobutylxanthine; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cyclic AMP; Dinoprostone; Escherichia coli; Humans; Imidazoles; Interleukin-1; Lipopolysaccharides; Monocytes; Thiazoles; Tumor Necrosis Factor-alpha | 1993 |
Inhibition of interleukin-1 beta production by SKF86002: evidence of two sites of in vitro activity and of a time and system dependence.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Fibroblasts; Humans; Imidazoles; Interleukin-1; Kinetics; Leukocytes, Mononuclear; Lipopolysaccharides; Protein Biosynthesis; Thiazoles | 1995 |
Mechanism of action of bicyclic imidazoles defines a translational regulatory pathway for tumor necrosis factor alpha.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Base Sequence; Cell Line; Centrifugation, Density Gradient; Culture Media, Conditioned; Gene Expression Regulation; Humans; Imidazoles; Kinetics; Molecular Sequence Data; Monocytes; Protein Biosynthesis; Ribosomes; RNA, Messenger; Thiazoles; Tumor Necrosis Factor-alpha | 1995 |
Inhibition of CD44, CD45 and LFA-3 mediated cytokine release from human monocytes by SK&F 86002 and pentoxifylline.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antigens, CD; CD58 Antigens; Humans; Imidazoles; In Vitro Techniques; Interleukin-1; Leukocyte Common Antigens; Lipopolysaccharides; Membrane Glycoproteins; Monocytes; Pentoxifylline; Receptors, Lymphocyte Homing; Thiazoles; Tumor Necrosis Factor-alpha | 1993 |
Effect of selective phosphodiesterase type IV inhibitor, rolipram, on fluid and cellular phases of inflammatory response.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Calcimycin; Cells, Cultured; Colforsin; Cyclic Nucleotide Phosphodiesterases, Type 4; Ear, External; Eicosanoids; Histamine Release; Humans; Imidazoles; Inflammation; Leukotriene B4; Male; Mast Cells; Mice; Mice, Inbred BALB C; Monocytes; Nadolol; Naproxen; Neutrophils; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyrazoles; Pyrrolidinones; Receptors, Adrenergic, beta; Rolipram; SRS-A; Thiazoles | 1993 |
Differentiation in vivo of classical non-steroidal antiinflammatory drugs from cytokine suppressive antiinflammatory drugs and other pharmacological classes using mouse tumour necrosis factor alpha production.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; Imidazoles; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Prodrugs; Thiazoles; Tumor Necrosis Factor-alpha | 1993 |
Dissociation of IL-1 beta synthesis and secretion in human blood monocytes stimulated with bacterial cell wall products.
Topics: Amino Acid Sequence; Caspase 1; Cell Wall; Cells, Cultured; Cycloheximide; Humans; Imidazoles; Interleukin-1; Interleukin-10; Lipopolysaccharides; Metalloendopeptidases; Molecular Sequence Data; Monocytes; Staphylococcus aureus; Thiazoles; Tumor Necrosis Factor-alpha | 1993 |
Effects of pyridinyl imidazole compounds on murine TNF-alpha production.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Humans; Imidazoles; Indoles; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Monocytes; Oxindoles; Shock, Septic; Thiazoles; Tumor Necrosis Factor-alpha | 1993 |
Pyridinyl imidazoles inhibit IL-1 and TNF production at the protein level.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Imidazoles; Interleukin-1; Lipopolysaccharides; Monocytes; Protein Biosynthesis; RNA, Messenger; Thiazoles; Tumor Necrosis Factor-alpha | 1993 |
The effects of antiinflammatory and antiallergic drugs on cytokine release after stimulation of human whole blood by lipopolysaccharide and zymosan A.
Topics: Anti-Allergic Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Dexamethasone; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Humans; Imidazoles; Interleukin-1; Interleukin-6; Interleukin-8; Leukocytes; Lipopolysaccharides; Lipoxygenase Inhibitors; Male; Phosphodiesterase Inhibitors; Pyrrolidinones; Regression Analysis; Rolipram; Thiazoles; Tumor Necrosis Factor-alpha; Zymosan | 1995 |
Cytokine inhibition preserves renal hemodynamic function following mesangial cell immune injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Cytokines; Eicosanoids; Glomerular Filtration Rate; Glomerular Mesangium; Imidazoles; Inflammation Mediators; Male; Rats; Rats, Wistar; Renal Circulation; Thiazoles; Tumor Necrosis Factor-alpha | 1996 |
SK&F 86002, a dual cytokine and eicosanoid inhibitor, attenuates endotoxin-induced cardiopulmonary dysfunction in the pig.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Eicosanoids; Endotoxemia; Heart; Imidazoles; Lipopolysaccharides; Lung; Peroxidase; Stroke Volume; Swine; Thiazoles; Thromboxanes; Tumor Necrosis Factor-alpha; Vascular Resistance | 1996 |
Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion; Chemotaxis; Chromatography, Ion Exchange; Electrophoresis, Polyacrylamide Gel; Humans; Imidazoles; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phosphorylation; Platelet Activating Factor; Precipitin Tests; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-jun; Proto-Oncogene Proteins c-raf; Recombinant Proteins; Saccharomyces cerevisiae Proteins; Signal Transduction; Superoxides; Thiazoles; Time Factors; Virulence Factors, Bordetella | 1997 |
Inhibition of prostaglandin endoperoxide synthase-2 expression in stimulated human monocytes by inhibitors of p38 mitogen-activated protein kinase.
Topics: Arachidonate 5-Lipoxygenase; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; Interleukin-1; Mitogen-Activated Protein Kinases; Monocytes; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Pyridines; RNA, Messenger; Thiazoles | 1997 |
Mast cell tumor necrosis factor alpha production is regulated by MEK kinases.
Topics: Androstadienes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Activation; Enzyme Inhibitors; Glutathione Transferase; Imidazoles; JNK Mitogen-Activated Protein Kinases; Kinetics; Luciferases; MAP Kinase Kinase Kinase 1; Mast Cells; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Thiazoles; Transcription, Genetic; Transfection; Tumor Necrosis Factor-alpha; Wortmannin | 1997 |
High-throughput RT-PCR analysis of multiple transcripts using a microplate RNA isolation procedure.
Topics: Benzothiazoles; Cell Line; Diamines; DNA Primers; Electrophoresis, Agar Gel; Fluorescent Dyes; Gene Expression Regulation; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Imidazoles; Interleukin-1; Kinetics; Lactones; Lipopolysaccharides; Macrolides; Monocytes; Organic Chemicals; Polymerase Chain Reaction; Quinolines; RNA, Messenger; Solvents; Thiazoles; Transcription, Genetic; Tumor Necrosis Factor-alpha | 1997 |
Effects of SK&F 86002 on cytokine-stimulated IL6 production in cultured neonatal mouse calvaria and SaOS2 osteoblastic cells: the role of prostaglandins and other mechanisms of action.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cytokines; Humans; Imidazoles; Indomethacin; Interleukin-1; Interleukin-6; Mice; Osteoblasts; Prostaglandins; Skull; Thiazoles; Tumor Necrosis Factor-alpha | 1997 |
p38 mitogen-activated protein kinase-dependent and -independent intracellular signal transduction pathways leading to apoptosis in human neutrophils.
Topics: Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Humans; Imidazoles; Mitogen-Activated Protein Kinases; Neutrophils; p38 Mitogen-Activated Protein Kinases; Signal Transduction; Stress, Mechanical; Thiazoles | 1998 |
Inhibition of kinases impairs neutrophil activation and killing of Staphylococcus aureus.
Topics: Androstadienes; Blood Bactericidal Activity; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Respiratory Burst; Staphylococcus aureus; Thiazoles; Wortmannin | 1998 |
p38 Kinase is a negative regulator of angiotensin II signal transduction in vascular smooth muscle cells: effects on Na+/H+ exchange and ERK1/2.
Topics: Angiotensin II; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Dimethyl Sulfoxide; Enzyme Inhibitors; Free Radical Scavengers; Histidine; Imidazoles; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinases; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Signal Transduction; Sodium-Hydrogen Exchangers; Substrate Specificity; Thiazoles | 1998 |
The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha.
Topics: 3T3 Cells; Animals; Calcium-Calmodulin-Dependent Protein Kinases; COS Cells; DNA-Binding Proteins; Endothelial Growth Factors; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; Lymphokines; MAP Kinase Kinase 6; MAP Kinase Kinase Kinase 1; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neovascularization, Pathologic; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Receptors, Chemokine; Response Elements; Sarcoma, Kaposi; Thiazoles; Transcription Factors; Transcriptional Activation; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Viral Proteins | 2000 |
Transcriptional cross-talk between Smad, ERK1/2, and p38 mitogen-activated protein kinase pathways regulates transforming growth factor-beta-induced aggrecan gene expression in chondrogenic ATDC5 cells.
Topics: Aggrecans; Animals; Butadienes; Cell Differentiation; Cell Line; Cell Nucleus; Chondrocytes; Cycloheximide; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Activation; Extracellular Matrix Proteins; Gene Expression Regulation, Enzymologic; Genes, Dominant; Imidazoles; Immunoblotting; Lectins, C-Type; Luciferases; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Synthesis Inhibitors; Proteoglycans; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Smad Proteins; Thiazoles; Time Factors; Trans-Activators; Transcription, Genetic; Transfection; Transforming Growth Factor beta | 2001 |
Role of p38 mitogen-activated protein kinase in chemokine-induced emigration and chemotaxis in vivo.
Topics: Animals; Cell Adhesion; Chemokine CXCL1; Chemokines; Chemokines, CXC; Chemotaxis, Leukocyte; Cytokines; Enzyme Inhibitors; Imidazoles; Infusions, Intravenous; Injections, Intravenous; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Microscopy, Video; Mitogen-Activated Protein Kinases; Muscle, Skeletal; Neutrophil Infiltration; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Thiazoles | 2001 |
OxLDL upregulates CXCR2 expression in monocytes via scavenger receptors and activation of p38 mitogen-activated protein kinase.
Topics: Cell Adhesion; Chemotaxis, Leukocyte; Coculture Techniques; Dextran Sulfate; Endothelium, Vascular; Enzyme Activation; Flow Cytometry; Humans; Imidazoles; Interleukin-8; Lipoproteins, LDL; Membrane Proteins; Mitogen-Activated Protein Kinases; Monocytes; p38 Mitogen-Activated Protein Kinases; Poly I; Pyridines; Receptors, Immunologic; Receptors, Interleukin-8B; Receptors, Lipoprotein; Receptors, Scavenger; RNA, Messenger; Scavenger Receptors, Class B; Thiazoles; U937 Cells | 2002 |
The effects of a cytokine suppressive anti-inflammatory drug on the output of prostaglandin E(2) and interleukin-1 beta from human fetal membranes.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Culture Techniques; Cyclooxygenase 2; Dinoprostone; Extraembryonic Membranes; Female; Gene Expression; Humans; Imidazoles; Interleukin-1; Isoenzymes; Lipopolysaccharides; Membrane Proteins; Pregnancy; Prostaglandin-Endoperoxide Synthases; Thiazoles | 2002 |
Differential activation of the c-Jun N-terminal kinase pathway in arsenite-induced apoptosis and sensitization of chemically resistant compared to susceptible B-lymphoma cell lines.
Topics: Apoptosis; Arsenites; B-Lymphocytes; Burkitt Lymphoma; Dose-Response Relationship, Drug; Drug Resistance; Drug Synergism; Enzyme Inhibitors; Hot Temperature; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Proteins; Thiazoles; Tumor Cells, Cultured | 2002 |
P38 MAPK: critical molecule in thrombin-induced NF-kappa B-dependent leukocyte recruitment.
Topics: Adenosine Triphosphate; Binding Sites; Binding, Competitive; Cell Adhesion; Cells, Cultured; E-Selectin; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; Leukocytes; Mitogen-Activated Protein Kinases; NF-kappa B; P-Selectin; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Thiazoles; Thrombin; Umbilical Veins | 2003 |
p38 MAP kinase negatively regulates angiotensin II-mediated effects on cell cycle molecules in human coronary smooth muscle cells.
Topics: Angiotensin II; Cell Cycle; Cells, Cultured; Cyclin D1; DNA; Enzyme Inhibitors; Humans; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Myocardium; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Retinoblastoma Protein; Thiazoles | 2003 |
Role of the p38 MAPK pathway in cisplatin-based therapy.
Topics: Animals; Antineoplastic Agents; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Survival; Cisplatin; COS Cells; Cross-Linking Reagents; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Resistance, Neoplasm; Enzyme Activation; Enzyme Inhibitors; HeLa Cells; Humans; Imidazoles; Kinetics; MAP Kinase Kinase 3; MAP Kinase Kinase 6; Mitogen-Activated Protein Kinase 12; Mitogen-Activated Protein Kinase 13; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phenotype; Phosphorylation; Plasmids; Platinum Compounds; Precipitin Tests; Protein Isoforms; Protein-Tyrosine Kinases; Pyridines; Signal Transduction; Thiazoles; Transfection; Tumor Cells, Cultured | 2003 |
A Biacore biosensor method for detailed kinetic binding analysis of small molecule inhibitors of p38alpha mitogen-activated protein kinase.
Topics: Animals; Escherichia coli; Imidazoles; Kinetics; Mice; Mitogen-Activated Protein Kinases; Molecular Structure; Phosphorylation; Protein Binding; Protein Denaturation; Pyridines; Recombinant Proteins; Surface Plasmon Resonance; Thiazoles | 2004 |
p38 MAP kinase inhibition ameliorates cisplatin nephrotoxicity in mice.
Topics: Animals; Cell Line; Cisplatin; Enzyme Activation; Enzyme Inhibitors; Free Radical Scavengers; Imidazoles; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; p38 Mitogen-Activated Protein Kinases; Pyridines; Reactive Oxygen Species; Thiazoles; Thiourea; Tumor Necrosis Factor-alpha | 2005 |
Low density lipoproteins inhibit the Na+/H+ antiport in human platelets via activation of p38MAP kinase.
Topics: Blood Platelets; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Humans; Hydrogen Peroxide; Imidazoles; Lipoproteins, LDL; MAP Kinase Kinase 3; MAP Kinase Kinase 6; MAP Kinase Signaling System; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Peptides; Phosphorylation; Propionates; Sodium-Hydrogen Exchangers; Thiazoles; Thrombin; Time Factors | 2006 |
6-Hydroxydopamine activates the mitochondrial apoptosis pathway through p38 MAPK-mediated, p53-independent activation of Bax and PUMA.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Cell Line, Tumor; Enzyme Inhibitors; Fibroblasts; Green Fluorescent Proteins; Humans; Imidazoles; Mice; Mice, Knockout; Mitochondria; Mitochondrial Swelling; Neuroblastoma; Neurons; Oxidopamine; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins; Sympatholytics; Thiazoles; Transfection; Tumor Suppressor Protein p53 | 2008 |
Activation of p38MAPK contributes to expanded polyglutamine-induced cytotoxicity.
Topics: Animals; Ataxin-1; Ataxins; Cell Death; Cell Line; Cell Survival; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Humans; Imidazoles; Isoenzymes; Mice; Mice, Transgenic; Nerve Tissue Proteins; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; Peptides; Protein Kinase C; Pyridines; Rabbits; RNA Interference; Thiazoles | 2008 |
p38 MAPK regulates ischemia-reperfusion-induced recruitment of leukocytes in the colon.
Topics: Animals; Cell Adhesion; Colitis; Colon; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Inhibitors; Imidazoles; Leukocytes; Mast Cells; Mice; Mice, Inbred C57BL; P-Selectin; p38 Mitogen-Activated Protein Kinases; Pyrimidines; Reperfusion Injury; Signal Transduction; Thiazoles; Tumor Necrosis Factor-alpha | 2009 |
Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002.
Topics: Adenosine Triphosphate; AMP-Activated Protein Kinases; Binding, Competitive; Crystallization; Crystallography, X-Ray; Escherichia coli; Fluorescent Dyes; High-Throughput Screening Assays; Humans; Imidazoles; Ligands; MAP Kinase Kinase Kinase 5; Mitogen-Activated Protein Kinase 14; Molecular Probes; Protein Binding; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-hck; Proto-Oncogene Proteins c-pim-1; Recombinant Proteins; Thiazoles | 2014 |
Suppression of problematic compound oligomerization by cosolubilization of nondetergent sulfobetaines.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Betaine; Drug Discovery; Imidazoles; Magnetic Resonance Spectroscopy; Solubility; Solutions; Thiazoles | 2015 |
p38 MAPK Inhibition Improves Synaptic Plasticity and Memory in Angiotensin II-dependent Hypertensive Mice.
Topics: Angiotensin II; Animals; Dendritic Spines; Disease Models, Animal; Hippocampus; Humans; Hypertension; Imidazoles; Long-Term Potentiation; Mice; Neuronal Plasticity; p38 Mitogen-Activated Protein Kinases; Pyramidal Cells; Signal Transduction; Thiazoles | 2016 |
Solvatochromism and linear solvation energy relationship of the kinase inhibitor SKF86002.
Topics: Cyclohexanes; Hydrogen Bonding; Imidazoles; Linear Models; Molecular Conformation; Protein Kinase Inhibitors; Solutions; Solvents; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Thermodynamics; Thiazoles | 2017 |
Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dihydroorotate Dehydrogenase; Hematologic Neoplasms; Humans; Imidazoles; K562 Cells; Mice; Oxidoreductases Acting on CH-CH Group Donors; Thiazoles; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2019 |