thiazoles has been researched along with sb 649868 in 8 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bettica, P; Boyle, G; Nash, M; Pellegatti, M; Renzulli, C; Thomas, S; Wright, M; Zamuner, S | 1 |
| Alexander, R; Bettica, P; Gomeni, R; Nucci, G; Pyke, C; Ratti, E; Squassante, L; Zamuner, S | 1 |
| Bettica, P; Dijk, DJ; Gennery, B; Groeger, JA; Squassante, L; Winsky-Sommerer, R | 1 |
| Antolini, M; Corsi, M; di Fabio, R; Faedo, S; Merlo Pich, E; Perdonà, E | 1 |
| Bettica, P; Danker-Hopfe, H; Nucci, G; Ratti, E; Squassante, L; Zamuner, S | 1 |
| Czajkowska, B; Krzystanek, M; Lapray, D; Markowski, G; Pałasz, A; Peyron, C; Rojczyk-Gołębiewska, E; Skowronek, R; Wiaderkiewicz, R | 1 |
| Hoyer, D; Jacobson, LH | 1 |
| Bullmore, ET; Kanakaraj, P; Koch, A; Lawrence, P; Miller, SR; Napolitano, A; Nathan, PJ; Patel, AX | 1 |
2 review(s) available for thiazoles and sb 649868
| Article | Year |
|---|---|
Dual orexin receptor antagonists - promising agents in the treatment of sleep disorders.
Topics: Acetamides; Animals; Azepines; Benzofurans; Humans; Isoquinolines; Models, Biological; Orexin Receptor Antagonists; Orexin Receptors; Piperidines; Pyrimidines; Sleep; Sleep Initiation and Maintenance Disorders; Thiazoles; Triazoles; Wakefulness | 2014 |
Orexin in sleep, addiction and more: is the perfect insomnia drug at hand?
Topics: Acetamides; Animals; Azepines; Behavior, Addictive; Benzofurans; Feeding Behavior; Humans; Intracellular Signaling Peptides and Proteins; Isoquinolines; Mice; Neuropeptides; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Piperidines; Pyrimidines; Rats; Reward; Sleep; Sleep Initiation and Maintenance Disorders; Thiazoles; Triazoles | 2013 |
5 trial(s) available for thiazoles and sb 649868
| Article | Year |
|---|---|
Disposition and metabolism of [14C]SB-649868, an orexin 1 and 2 receptor antagonist, in humans.
Topics: Administration, Oral; Adult; Benzofurans; Biotransformation; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Feces; Humans; Male; Mass Spectrometry; Middle Aged; Molecular Structure; Orexin Receptors; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Thiazoles; Tissue Distribution | 2011 |
Phase I studies on the safety, tolerability, pharmacokinetics and pharmacodynamics of SB-649868, a novel dual orexin receptor antagonist.
Topics: Adolescent; Adult; Arousal; Benzofurans; Cognition; Dose-Response Relationship, Drug; Drug Interactions; Electroencephalography; Half-Life; Humans; Hypnotics and Sedatives; Male; Middle Aged; Orexin Receptors; Polysomnography; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Simvastatin; Single-Blind Method; Sleep; Sleep Stages; Thiazoles; Wakefulness | 2012 |
Differential effects of a dual orexin receptor antagonist (SB-649868) and zolpidem on sleep initiation and consolidation, SWS, REM sleep, and EEG power spectra in a model of situational insomnia.
Topics: Adolescent; Adult; Analysis of Variance; Benzofurans; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Electroencephalography; GABA-A Receptor Agonists; Humans; Male; Middle Aged; Neuropsychological Tests; Orexin Receptors; Polysomnography; Psychomotor Performance; Pyridines; Reaction Time; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Sleep Initiation and Maintenance Disorders; Sleep, REM; Surveys and Questionnaires; Thiazoles; Wakefulness; Young Adult; Zolpidem | 2012 |
The orexin antagonist SB-649868 promotes and maintains sleep in men with primary insomnia.
Topics: Adolescent; Adult; Benzofurans; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Germany; Humans; Intracellular Signaling Peptides and Proteins; Male; Memory; Middle Aged; Neuropeptides; Orexins; Placebos; Polysomnography; Sleep; Sleep Initiation and Maintenance Disorders; Sleep, REM; Surveys and Questionnaires; Thiazoles; Time Factors; Young Adult | 2012 |
Neuroendocrine and sympathetic responses to an orexin receptor antagonist, SB-649868, and alprazolam following insulin-induced hypoglycemia in humans.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Alprazolam; Anti-Anxiety Agents; Benzofurans; Cross-Over Studies; Double-Blind Method; Growth Hormone; Heart Rate; Humans; Hypoglycemia; Insulin; Intracellular Signaling Peptides and Proteins; Male; Middle Aged; Neuropeptides; Neurosecretory Systems; Norepinephrine; Orexin Receptor Antagonists; Orexins; Prolactin; Sympathetic Nervous System; Thiazoles; Young Adult | 2014 |
1 other study(ies) available for thiazoles and sb 649868
| Article | Year |
|---|---|
Functional and binding kinetic studies make a distinction between OX1 and OX2 orexin receptor antagonists.
Topics: Acetamides; Animals; Benzofurans; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Dioxanes; Humans; Isoquinolines; Kinetics; Orexin Receptors; Phenylurea Compounds; Piperidines; Protein Binding; Pyrimidines; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Thiazoles | 2012 |