Compounds > thiazoles
Page last updated: 2024-08-21

thiazoles and ro 61-8048

thiazoles has been researched along with ro 61-8048 in 39 studies

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (12.82)18.2507
2000's13 (33.33)29.6817
2010's16 (41.03)24.3611
2020's5 (12.82)2.80

Authors

AuthorsStudies
Cesura, AM; Huguenin, P; Kettler, R; Röver, S; Szente, A1
Chiarugi, A; Moroni, F; Rapizzi, E1
Carpenedo, R; Cozzi, A; Moroni, F1
Chiarugi, A; Moroni, F1
Carpenedo, R; Cozzi, A; Moroni, F; Pellegrini-Giampietro, DE; Peruginelli, F1
Obrenovitch, TP; Urenjak, J2
Amiridze, N; Brown, OR; Dale, WE; Dang, Y1
Ballerini, C; Chiarugi, A; Cozzi, A; Massacesi, L; Moroni, F1
Carpenedo, R; Meli, E; Moroni, F; Pellegrini-Giampietro, DE; Peruginelli, F1
Hamann, M; Richter, A1
Carpendo, R; Cipriani, G; Cozzi, A; Izzo, E; Moroni, F; Veneroni, O1
Bédard, PJ; Grégoire, L; Guidetti, P; Izzo, E; Rassoulpour, A; Samadi, P; Schwarcz, R1
Bustamante, S; Clark, CJ; Mackay, GM; Phillips, RS; Smythe, GA; Stone, TW1
Bédard, PJ; Di Paolo, T; Grégoire, L; Guidetti, P; Izzo, E; Rassoulpour, A; Samadi, P; Schwarcz, R1
Hamann, M; Richter, A; Sander, SE1
Ball, HJ; Hunt, NH; Mellor, AL; Miu, J1
Barrett, MP; Bradley, B; Kennedy, PG; Rodgers, J; Stone, TW1
Di Paolo, T; Grégoire, L; Lévesque, D; Morissette, M; Ouattara, B; Rouillard, C; Samadi, P; Tamim, MK1
Bellac, CL; Christen, S; Coimbra, RS; Leib, SL1
Adame, A; Andrews-Zwilling, Y; Flik, G; Giorgini, F; Guidetti, P; Hsieh, EW; Huang, SY; Huang, Y; Laue, G; Lee, J; Louie, JY; Masliah, E; Moussaoui, S; Muchowski, JM; Muchowski, PJ; Notarangelo, FM; Patrick, C; Rassoulpour, A; Sathyasaikumar, KV; Scearce-Levie, K; Schwarcz, R; Truong, J; Wu, HQ; Wu, T; Zwilling, D1
Chiarini, LB; Dias, F; Lima, VL; Nunes, RD; Oliveira, PL; Perales, J; Pereira, LO; Ramos, TD; Santos, TS; Silva-Mendes, BJ; Valente, RH1
Beconi, MG; Clifton, S; Dominguez, C; Lyons, K; Matthews, K; Mead, T; Munoz-Sanjuan, I; O'Connell, C; Prime, M; Toledo-Sherman, L; Walter, D; Winkler, D; Yates, D1
Di Paolo, T; Morissette, M; Parent, M; Riahi, G; Samadi, P1
Darlington, LG; Forrest, CM; Gonzalez, N; Jerusalinsky, D; Khalil, OS; Kornisiuk, E; McNair, K; Pisar, M; Snitcofsky, M; Stone, TW1
Barnes, C; Bergman, J; Ferré, S; Fratta, W; Goldberg, SR; Justinova, Z; Kangas, BD; Mascia, P; Panlilio, LV; Parashos, A; Pistis, M; Redhi, GH; Scherma, M; Schwarcz, R; Secci, ME; Solinas, M; Tanda, G; Wu, HQ; Zara, T1
Darlington, LG; Forrest, CM; Khalil, OS; Pisar, M; Stone, TW; Vincenten, MC1
Darlington, LG; Forrest, CM; Khalil, OS; McNair, K; Pisar, M; Qasem, S; Stone, TW; Vincenten, MC1
Cannella, N; Spanagel, R; Takahashi, T; Vengeliene, V1
Auber, A; Goldberg, SR; Justinova, Z; Panlilio, LV; Redhi, GH; Schindler, CW; Schwarcz, R; Secci, ME; Thorndike, EB1
Gao, J; Liao, X; Xia, T; Xiang, Y; Yao, L; Zhu, D1
Cha, H; Cho, JM; Chung, J; Hwang, KY; Kim, HT; Kim, S; Kwon, SK; Na, BK; Son, J1
Abuin-Martínez, C; Colado, MI; Giménez-Gómez, P; Gutiérrez-López, MD; O'Shea, E; Pérez-Hernández, M; Vidal, R1
Beggiato, S; Borelli, AC; Bradberry, CW; Ferraro, L; Ferré, S; Goldberg, SR; Justinova, Z; Mascia, P; Melis, M; Panlilio, LV; Pistis, M; Sagheddu, C; Schindler, CW; Schwarcz, R; Secci, ME; Tanda, G; Tomasini, MC1
Li, Q; Sherchan, P; Tang, J; Zakhary, G; Zhang, JH1
Chiu, YH; Chung, TF; Hsu, CH; Huang, KC; Huang, WH; Liao, AT; Lin, CS; Liu, CC; Liu, IL1
Collier, ME; Giorgini, F; Scrutton, NS; Zhang, S1
Ando, T; Hoshi, M; Kubo, H; Nakamoto, K; Saito, K; Tashita, C; Tezuka, H; Yamamoto, Y1
Colado, MI; Gil de Biedma-Elduayen, L; Giménez-Gómez, P; Gutiérrez-López, MD; Morales-Puerto, N; Núñez-de la Calle, C; O'Shea, E; Vidal, R1

Reviews

1 review(s) available for thiazoles and ro 61-8048

ArticleYear
Inflammation control and improvement of cognitive function in COVID-19 infections: is there a role for kynurenine 3-monooxygenase inhibition?
    Drug discovery today, 2021, Volume: 26, Issue:6

    Topics: Animals; Cognition; COVID-19; Humans; Inflammation; Kynurenine; Kynurenine 3-Monooxygenase; Neuroprotective Agents; Signal Transduction; Sulfonamides; Thiazoles; Tryptophan

2021

Other Studies

38 other study(ies) available for thiazoles and ro 61-8048

ArticleYear
Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase.
    Journal of medicinal chemistry, 1997, Dec-19, Volume: 40, Issue:26

    Topics: Animals; Brain; Enzyme Inhibitors; Extracellular Space; Gerbillinae; Kidney; Kinetics; Kynurenic Acid; Kynurenine 3-Monooxygenase; Liver; Mitochondria; Mixed Function Oxygenases; Molecular Structure; Neuroprotective Agents; Rats; Structure-Activity Relationship; Sulfonamides; Thiazoles

1997
The kynurenine metabolic pathway in the eye: studies on 3-hydroxykynurenine, a putative cataractogenic compound.
    FEBS letters, 1999, Jun-18, Volume: 453, Issue:1-2

    Topics: Alanine; Animals; Cataract; Ciliary Body; Eye; Hydrolases; Iris; Kynurenine; Kynurenine 3-Monooxygenase; Lens, Crystalline; Lyases; Male; Mixed Function Oxygenases; Rabbits; Sulfonamides; Thiazoles; Tissue Distribution; Transaminases; Tryptophan Oxygenase

1999
Kynurenine hydroxylase inhibitors reduce ischemic brain damage: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(nitrophenyl)thiazol-2yl]-benzenesulfonamide (Ro 61-8048) in models of focal or global brain ischemia.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1999, Volume: 19, Issue:7

    Topics: Alanine; Animals; Brain Ischemia; Enzyme Inhibitors; Gerbillinae; Kynurenine 3-Monooxygenase; Male; Mixed Function Oxygenases; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Sulfonamides; Thiazoles

1999
Quinolinic acid formation in immune-activated mice: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(-3-nitrophenyl)thiazol-2yl]-benzenesul fonamide (Ro 61-8048), two potent and selective inhibitors of kynurenine hydroxylase.
    Neuropharmacology, 1999, Volume: 38, Issue:8

    Topics: Alanine; Animals; Brain; Enzyme Inhibitors; Hydroxylation; Kynurenine 3-Monooxygenase; Liver; Male; Mice; Mixed Function Oxygenases; Pokeweed Mitogens; Quinolinic Acid; Spleen; Sulfonamides; Thiazoles

1999
Neuroprotective effects of kynurenine-3-hydroxylase inhibitors in models of brain ischemia.
    Advances in experimental medicine and biology, 1999, Volume: 467

    Topics: Alanine; Animals; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Enzyme Inhibitors; Gerbillinae; Hippocampus; In Vitro Techniques; Ischemic Attack, Transient; Kynurenine 3-Monooxygenase; Mixed Function Oxygenases; Neuroprotective Agents; Pyramidal Cells; Rats; Rats, Wistar; Sulfonamides; Thiazoles

1999
In vivo assessment of kynurenate neuroprotective potency and quinolinate excitotoxicity.
    Amino acids, 2000, Volume: 19, Issue:1

    Topics: Animals; Enzyme Inhibitors; Frontal Lobe; Kynurenic Acid; Male; Neuroprotective Agents; Quinolinic Acid; Rats; Sulfonamides; Thiazoles

2000
Evidence that kynurenine pathway metabolites mediate hyperbaric oxygen-induced convulsions.
    Toxicology letters, 2000, Sep-30, Volume: 117, Issue:1-2

    Topics: Animals; Coma; Enzyme Inhibitors; Hyperbaric Oxygenation; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mixed Function Oxygenases; ortho-Aminobenzoates; Rats; Rats, Sprague-Dawley; Seizures; Sulfonamides; Thiazoles; Time Factors; Tryptophan

2000
Kynurenine 3-hydroxylase inhibition in rats: effects on extracellular kynurenic acid concentration and N-methyl-D-aspartate-induced depolarisation in the striatum.
    Journal of neurochemistry, 2000, Volume: 75, Issue:6

    Topics: Administration, Oral; Animals; Cerebral Cortex; Corpus Striatum; Electroencephalography; Enzyme Inhibitors; Extracellular Space; Injections, Intraperitoneal; Kynurenic Acid; Kynurenine 3-Monooxygenase; Male; Membrane Potentials; Microdialysis; Mixed Function Oxygenases; N-Methylaspartate; Neuroprotective Agents; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Sulfonamides; Thiazoles

2000
Kynurenine 3-mono-oxygenase activity and neurotoxic kynurenine metabolites increase in the spinal cord of rats with experimental allergic encephalomyelitis.
    Neuroscience, 2001, Volume: 102, Issue:3

    Topics: Animals; Astrocytes; Brain; Cytoplasmic Granules; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Female; Immunohistochemistry; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Mixed Function Oxygenases; Multiple Sclerosis; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Spinal Cord; Sulfonamides; Thiazoles

2001
Kynurenine 3-mono-oxygenase inhibitors attenuate post-ischemic neuronal death in organotypic hippocampal slice cultures.
    Journal of neurochemistry, 2002, Volume: 82, Issue:6

    Topics: Alanine; Animals; Brain Ischemia; Cell Death; Cell Hypoxia; Culture Media, Conditioned; Enzyme Inhibitors; Glucose; Hippocampus; In Vitro Techniques; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Mixed Function Oxygenases; Neurons; Neuroprotective Agents; Pyramidal Cells; Quinolinic Acid; Rats; Sulfonamides; Thiazoles

2002
The kynurenine 3-hydroxylase inhibitor Ro 61-8048 improves dystonia in a genetic model of paroxysmal dyskinesia.
    European journal of pharmacology, 2003, Sep-30, Volume: 478, Issue:1

    Topics: Animals; Chorea; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Dystonia; Enzyme Inhibitors; Female; Kynurenine 3-Monooxygenase; Male; Mesocricetus; Mixed Function Oxygenases; Sulfonamides; Thiazoles

2003
Kynurenine 3-mono-oxygenase inhibitors reduce glutamate concentration in the extracellular spaces of the basal ganglia but not in those of the cortex or hippocampus.
    Neuropharmacology, 2005, Volume: 48, Issue:6

    Topics: Animals; Avoidance Learning; Basal Ganglia; Behavior, Animal; Brain Chemistry; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Interactions; Extracellular Space; Glutamic Acid; Kynurenic Acid; Kynurenine 3-Monooxygenase; Male; Microdialysis; Mixed Function Oxygenases; omega-Conotoxin GVIA; Potassium Chloride; Rats; Rats, Wistar; Statistics, Nonparametric; Sulfonamides; Thiazoles; Time Factors

2005
Effect of kynurenine 3-hydroxylase inhibition on the dyskinetic and antiparkinsonian responses to levodopa in Parkinsonian monkeys.
    Movement disorders : official journal of the Movement Disorder Society, 2005, Volume: 20, Issue:7

    Topics: Analysis of Variance; Animals; Antiparkinson Agents; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Dyskinesia, Drug-Induced; Female; Kynurenic Acid; Kynurenine 3-Monooxygenase; Levodopa; Macaca fascicularis; Mixed Function Oxygenases; Motor Activity; Parkinsonian Disorders; Quinolinic Acid; Sulfonamides; Thiazoles; Time Factors

2005
Prolonged survival of a murine model of cerebral malaria by kynurenine pathway inhibition.
    Infection and immunity, 2005, Volume: 73, Issue:8

    Topics: Animals; Chemokine CCL4; Disease Models, Animal; Kynurenine; Kynurenine 3-Monooxygenase; Macrophage Inflammatory Proteins; Malaria, Cerebral; Mice; Mice, Inbred C57BL; Mixed Function Oxygenases; ortho-Aminobenzoates; Picolinic Acids; Plasmodium berghei; Sulfonamides; Thiazoles

2005
Prolonged kynurenine 3-hydroxylase inhibition reduces development of levodopa-induced dyskinesias in parkinsonian monkeys.
    Behavioural brain research, 2008, Jan-25, Volume: 186, Issue:2

    Topics: Animals; Antiparkinson Agents; Behavior, Animal; Disease Models, Animal; Drug Interactions; Dyskinesia, Drug-Induced; Enzyme Inhibitors; Female; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Levodopa; Macaca fascicularis; Motor Activity; Parkinsonian Disorders; Quinolinic Acid; Sulfonamides; Thiazoles; Time Factors

2008
Effects of the kynurenine 3-hydroxylase inhibitor Ro 61-8048 after intrastriatal injections on the severity of dystonia in the dt sz mutant.
    European journal of pharmacology, 2008, May-31, Volume: 586, Issue:1-3

    Topics: Animals; Cricetinae; Dystonia; Enzyme Inhibitors; Kynurenine 3-Monooxygenase; Microinjections; Mutation; Neostriatum; Sulfonamides; Thiazoles

2008
Effect of indoleamine dioxygenase-1 deficiency and kynurenine pathway inhibition on murine cerebral malaria.
    International journal for parasitology, 2009, Volume: 39, Issue:3

    Topics: Animals; Brain; Enzyme Inhibitors; Female; Gas Chromatography-Mass Spectrometry; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Malaria, Cerebral; Metabolic Networks and Pathways; Mice; Mice, Inbred C57BL; Picolinic Acids; Quinolinic Acid; RNA, Messenger; Sulfonamides; Thiazoles; Tryptophan Oxygenase

2009
Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis.
    Brain : a journal of neurology, 2009, Volume: 132, Issue:Pt 5

    Topics: Animals; Blood-Brain Barrier; Central Nervous System Protozoal Infections; Female; Inhibitory Concentration 50; Kynurenine; Mice; Mice, Inbred Strains; Pentamidine; Signal Transduction; Sulfonamides; Thiazoles; Time Factors; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African

2009
Effect of non-dopaminergic drug treatment on Levodopa induced dyskinesias in MPTP monkeys: common implication of striatal neuropeptides.
    Neuropharmacology, 2010, Volume: 58, Issue:1

    Topics: Animals; Antiparkinson Agents; Benzoxazoles; Cocaine; Corpus Striatum; Disease Models, Animal; Docosahexaenoic Acids; Dopamine; Dopamine Uptake Inhibitors; Dynorphins; Dyskinesia, Drug-Induced; Enkephalins; Female; Iodine Isotopes; Levodopa; Macaca fascicularis; Naltrexone; Neuropeptides; Ovariectomy; Parkinsonian Disorders; Piperidines; Protein Precursors; RNA, Messenger; Sulfonamides; Tachykinins; Thiazoles; Time Factors

2010
Inhibition of the kynurenine-NAD+ pathway leads to energy failure and exacerbates apoptosis in pneumococcal meningitis.
    Journal of neuropathology and experimental neurology, 2010, Volume: 69, Issue:11

    Topics: Animals; Animals, Newborn; Apoptosis; Chromatography, High Pressure Liquid; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Energy Metabolism; Hippocampus; Kynurenine; Meningitis, Pneumococcal; Myelin Basic Protein; NAD; Rats; Rats, Wistar; Signal Transduction; Sulfonamides; Thiazoles

2010
Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration.
    Cell, 2011, Jun-10, Volume: 145, Issue:6

    Topics: Administration, Oral; Alzheimer Disease; Animals; Brain Chemistry; Disease Models, Animal; Female; Humans; Huntington Disease; Kynurenic Acid; Kynurenine 3-Monooxygenase; Male; Mice; Mice, Transgenic; Sulfonamides; Thiazoles

2011
The antioxidant role of xanthurenic acid in the Aedes aegypti midgut during digestion of a blood meal.
    PloS one, 2012, Volume: 7, Issue:6

    Topics: Aedes; Animals; Antioxidants; Chelating Agents; Chromatography, High Pressure Liquid; Digestion; Female; Gastrointestinal Tract; Heme; Hydrogen-Ion Concentration; Iron; Kynurenine 3-Monooxygenase; Mass Spectrometry; Molecular Structure; Sulfonamides; Thiazoles; Xanthurenates

2012
Metabolism and pharmacokinetics of JM6 in mice: JM6 is not a prodrug for Ro-61-8048.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; Area Under Curve; Cell Line; Dogs; Hepatocytes; Humans; Madin Darby Canine Kidney Cells; Male; Metabolic Detoxication, Phase I; Mice; Mice, Inbred C57BL; Microsomes, Liver; Prodrugs; Rats; Sulfonamides; Thiazoles

2012
Basal ganglia serotonin 1B receptors in parkinsonian monkeys with L-DOPA-induced dyskinesia.
    Biochemical pharmacology, 2013, Oct-01, Volume: 86, Issue:7

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Autoradiography; Basal Ganglia; Behavior, Animal; Benzamides; Brain; Case-Control Studies; Dyskinesia, Drug-Induced; Levodopa; Macaca fascicularis; Parkinson Disease; Pyridines; Receptor, Serotonin, 5-HT1B; Serotonin; Sulfonamides; Thiazoles

2013
Changes in synaptic transmission and protein expression in the brains of adult offspring after prenatal inhibition of the kynurenine pathway.
    Neuroscience, 2013, Dec-19, Volume: 254

    Topics: Age Factors; Animals; Brain; Doublecortin Protein; Down-Regulation; Excitatory Postsynaptic Potentials; Female; Kynurenine; Male; Neurogenesis; Organ Culture Techniques; Pregnancy; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Sulfonamides; Synaptic Transmission; Thiazoles

2013
Reducing cannabinoid abuse and preventing relapse by enhancing endogenous brain levels of kynurenic acid.
    Nature neuroscience, 2013, Volume: 16, Issue:11

    Topics: Analgesics; Animals; Benzoxazines; Brain; Cannabinoid Receptor Agonists; Conditioning, Operant; Cues; Discrimination, Psychological; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Drug-Seeking Behavior; Kynurenic Acid; Male; Memory, Short-Term; Morpholines; Naphthalenes; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Reinforcement, Psychology; Saimiri; Secondary Prevention; Self Administration; Substance-Related Disorders; Sulfonamides; Thiazoles; Time Factors; Wakefulness

2013
Prenatal inhibition of the kynurenine pathway leads to structural changes in the hippocampus of adult rat offspring.
    The European journal of neuroscience, 2014, Volume: 39, Issue:10

    Topics: Animals; Antigens, Nuclear; Dendrites; Dendritic Spines; Doublecortin Domain Proteins; Doublecortin Protein; Enzyme Inhibitors; Female; Hedgehog Proteins; Hippocampus; Kynurenine; Male; Microtubule-Associated Proteins; Nerve Tissue Proteins; Neurons; Neuropeptides; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Wistar; Signal Transduction; Sulfonamides; Thiazoles; Vesicle-Associated Membrane Protein 1; Vesicular Glutamate Transport Protein 1; Vesicular Glutamate Transport Protein 2; Vesicular Inhibitory Amino Acid Transport Proteins

2014
Modified neocortical and cerebellar protein expression and morphology in adult rats following prenatal inhibition of the kynurenine pathway.
    Brain research, 2014, Aug-12, Volume: 1576

    Topics: Animals; Cerebellum; Dendrites; Doublecortin Protein; Embryonic Development; Female; Gene Expression Regulation; Hippocampus; Kynurenine; Kynurenine 3-Monooxygenase; Neocortex; Nerve Tissue Proteins; Neurogenesis; Neuronal Plasticity; Neurons; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Sulfonamides; Synaptic Transmission; Thiazoles; Tryptophan

2014
Metabolic shift of the kynurenine pathway impairs alcohol and cocaine seeking and relapse.
    Psychopharmacology, 2016, Volume: 233, Issue:18

    Topics: Animals; Behavior, Animal; Central Nervous System Depressants; Cocaine; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Ethanol; Kynurenine; Kynurenine 3-Monooxygenase; Male; Metabolic Networks and Pathways; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Recurrence; Self Administration; Sulfonamides; Thiazoles

2016
Attenuating Nicotine Reinforcement and Relapse by Enhancing Endogenous Brain Levels of Kynurenic Acid in Rats and Squirrel Monkeys.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017, Volume: 42, Issue:8

    Topics: Animals; Cocaine; Dopamine; Isoxazoles; Kynurenic Acid; Male; Nicotine; Nucleus Accumbens; Phenylurea Compounds; Rats; Recurrence; Reinforcement, Psychology; Saimiri; Secondary Prevention; Self Administration; Sulfonamides; Thiazoles

2017
Biochemistry and structural studies of kynurenine 3-monooxygenase reveal allosteric inhibition by Ro 61-8048.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2018, Volume: 32, Issue:4

    Topics: Allosteric Regulation; Allosteric Site; Bacterial Proteins; Enzyme Inhibitors; HEK293 Cells; Humans; Kynurenine 3-Monooxygenase; Protein Binding; Pseudomonas fluorescens; Sulfonamides; Thiazoles

2018
Structural Basis for Inhibitor-Induced Hydrogen Peroxide Production by Kynurenine 3-Monooxygenase.
    Cell chemical biology, 2018, 04-19, Volume: 25, Issue:4

    Topics: Amino Acid Sequence; Animals; Enzyme Inhibitors; Flavins; Humans; Hydrogen Peroxide; Kynurenine 3-Monooxygenase; Molecular Docking Simulation; Oxidation-Reduction; Protein Conformation; Pseudomonas fluorescens; Saccharomyces cerevisiae; Sequence Alignment; Sulfonamides; Thiazoles

2018
Increasing kynurenine brain levels reduces ethanol consumption in mice by inhibiting dopamine release in nucleus accumbens.
    Neuropharmacology, 2018, Volume: 135

    Topics: Acetaldehyde; Alcohol Drinking; Animals; Binge Drinking; Brain; Central Nervous System Depressants; Disease Models, Animal; Dopamine; Enzyme Inhibitors; Ethanol; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mice, Inbred C57BL; Nucleus Accumbens; Receptors, Cholinergic; Sulfonamides; Thiazoles

2018
Astrocytic Mechanisms Involving Kynurenic Acid Control Δ
    Molecular neurobiology, 2019, Volume: 56, Issue:5

    Topics: Action Potentials; alpha7 Nicotinic Acetylcholine Receptor; Animals; Astrocytes; Brain; Cells, Cultured; Dronabinol; Glutamic Acid; Kynurenic Acid; Male; Nucleus Accumbens; Prefrontal Cortex; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reward; Rimonabant; RNA, Messenger; Sulfonamides; Thiazoles; Ventral Tegmental Area

2019
Modification of kynurenine pathway via inhibition of kynurenine hydroxylase attenuates surgical brain injury complications in a male rat model.
    Journal of neuroscience research, 2020, Volume: 98, Issue:1

    Topics: Animals; Apoptosis; Brain Edema; Brain Injuries; Cytokines; Disease Models, Animal; Kynurenine; Kynurenine 3-Monooxygenase; Male; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Sulfonamides; Thiazoles

2020
Kynurenine 3-monooxygenase (KMO), and signal transducer and activator of transcription 3 (STAT3) expression is involved in tumour proliferation and predicts poor survival in canine melanoma.
    Veterinary and comparative oncology, 2021, Volume: 19, Issue:1

    Topics: Animals; Cell Line; Cell Survival; Dog Diseases; Dogs; Down-Regulation; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Kynurenine 3-Monooxygenase; Male; Melanoma; Signal Transduction; STAT3 Transcription Factor; Sulfonamides; Survival; Thiazoles

2021
3-Hydroxykynurenine Regulates Lipopolysaccharide-Stimulated IL-6 Production and Protects against Endotoxic Shock in Mice.
    ImmunoHorizons, 2021, 06-28, Volume: 5, Issue:6

    Topics: Activating Transcription Factor 4; Animals; Disease Models, Animal; Humans; Interleukin-6; Kynurenine; Kynurenine 3-Monooxygenase; Lipopolysaccharides; Liver; Macrophages; Male; Mice; Mice, Knockout; Shock, Septic; Signal Transduction; Sulfonamides; Thiazoles

2021
Influx of kynurenine into the brain is involved in the reduction of ethanol consumption induced by Ro 61-8048 after chronic intermittent ethanol in mice.
    British journal of pharmacology, 2022, Volume: 179, Issue:14

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Brain; Ethanol; Female; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mice; Mice, Inbred C57BL; Sulfonamides; Thiazoles

2022