Compounds > thiazoles
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thiazoles and ro 3306

thiazoles has been researched along with ro 3306 in 51 studies

Research

Studies (51)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (13.73)29.6817
2010's38 (74.51)24.3611
2020's6 (11.76)2.80

Authors

AuthorsStudies
Chen, L; Chen, S; Heimbrook, DC; Knezevic, D; Sun, H; Tovar, C; Vassilev, LT; Zhao, X1
Vassilev, LT1
Cot, E; Fisher, D; Krasinska, L1
Kellogg, DR; McCusker, D; Royou, A; Sullivan, W1
DePamphilis, ML; Kohn, MJ; Ullah, Z; Vassilev, LT; Yagi, R1
Andreeff, M; Kojima, K; Nakakuma, H; Shikami, M; Shimanuki, M1
Ma, HT; Marxer, M; Poon, RY; Tsang, YH1
Borowiec, AS; Capiod, T; Delcourt, P; Dewailly, E; El Boustany, C; Katsogiannou, M; Prevarskaya, N1
Krämer, A; Kreis, NN; Rödel, F; Sanhaji, M; Sommer, K; Strebhardt, K; Yuan, J1
Chircop, M; Gilbert, J; Gordon, CP; Jones, NC; Lau, H; Ma, MP; Mariana, A; McCluskey, A; Morokoff, A; O'Brien, TJ; Perera, S; Robinson, PJ; Sakoff, J; Young, KA1
Cao, C; Ling, Y; Liu, X; Ma, Q; Ma, R; Xu, Q; Yin, Q; Zhang, X; Zhang, Y; Zhong, H1
Mac Fhearraigh, S; Mc Gee, MM1
Aarts, M; Ashworth, A; Garcia-Murillas, I; Gevensleben, H; Hurd, MS; Sharpe, R; Shumway, SD; Toniatti, C; Turner, NC1
Bisselink, YJ; de Vries, EG; Heijink, AM; Krajewska, M; Seinstra, RI; Silljé, HH; van Vugt, MA1
Karess, RE; Menant, A1
Chai, W; Dai, X; Huang, C1
Boucrot, E; Kirchhausen, T; Santos, AJ; Tacheva-Grigorova, SK1
Coldwell, MJ; Cowan, JL; Mead, A; Morley, SJ; Perry, LS; Vlasak, M; Willett, M1
Aleksic, T; Chitnis, MM; Gao, S; Lodhia, KA; Macaulay, VM; Protheroe, AS1
Du, B; He, P; Lai, X; Qiu, P; Tan, Y; Wu, Y; Xiao, J1
Calvo-Asensio, I; Canavan, L; Eykelenboom, JK; Harte, EC; Llorens-Agost, M; Lowndes, NF; Pastor-Peidro, A1
Jang, WI; Kim, NH; Lee, SH; Lin, ZL; Namgoong, S1
Cai, Y; Jiang, W; Peng, R; Shi, Y; Wu, G; Xia, Q1
Antoniou-Kourounioti, M; Farr, CJ; Mimmack, ML; Porter, AC; Volkov, A1
Burgess, A; Caldon, CE; Castro, A; Lorca, T; McCloy, RA; Rogers, S1
Aleksic, T; Esashi, F; Gao, S; Lodhia, KA; Macaulay, VM1
Endo, A; Lamond, AI; Ly, T1
Eggert, A; Köster, J; Lee, S; Morik, K; Schramm, A; Schulte, JH; Schwermer, M; Stephan, H; van Maerken, T1
Dudka, D; El Dika, M; Kloc, M; Kubiak, JZ; Prigent, C; Tassan, JP1
Beijersbergen, R; Demmers, J; Marsman, J; Voets, E; Wolthuis, R1
Engelhardt, M; Felthaus, J; Follo, M; Greil, C; Krohs, J; Schnerch, D; Wäsch, R1
Goto, S; Kono, T; Morimoto, H; Moriya, S; Ogawa, H; Sakon, H; Takyu, R; Toei, S1
Dai, M; Han, X; Jallal, B; Liu, Z; Ma, J; Qin, Y; Qu, B; Shen, N; Tang, Y; Wang, Y; Wu, L; Wu, Y; Xia, S; Yao, Y; Zhang, X; Zhu, W1
Aarts, M; Ashworth, A; Bardelli, A; Brough, R; Campbell, J; Costa-Cabral, S; Konde, A; Lord, CJ; Marinari, E; Riffell, J; Torrance, C1
Chaube, SK; Koch, B; Prasad, S1
Adamo, ME; Cheng, C; Kettenbach, AN; Petrone, A1
Liu, X; Piao, Y; Qiu, N; Shen, Y; Tang, J; Zhao, B; Zhou, Q; Zhou, X; Zhou, Z; Zhu, D1
Cho, H; Chung, JY; Kang, ES; Kim, JH; Lee, EJ; Shin, HY; Yang, W1
Chen, L; Lo, CM; Ngan, ES; Poon, RY; Wang, XQ; Xu, A1
Ma, HT; Poon, RY1
Burdova, K; Lindqvist, A; Macurek, L; Müllers, E; Silva Cascales, H1
Blow, JJ; Carrington, JT; Frearson, JA; Gardner, NJ; Gillespie, PJ; Haagensen, EJ; McElroy, SP; Shanks, EJ; Woodland, A1
Harada, A; Komatsu, T; Kudou, K; Maehara, K; Maehara, Y; Nogami, J; Ohkawa, Y; Oki, E; Saeki, H1
Nilsson, J; Zhang, G1
Gucký, T; Hendrychová, D; Jorda, R; Kryštof, V; Řezníčková, E; Voller, J1
Li, Q; Luo, J; Shang, Z; Yang, Y; Zhang, B; Zhang, M1
Miki, Y; Saito, H; Sunada, S; Xu, Z; Zhang, D1
Cao, H; Jia, X; Lee, JC; Liu, X; Lu, X; Pang, Y; Shen, Y; Tu, L; Wang, Y1
Anko, M; Hasegawa, S; Matsumoto, KI; Ohara, M; Suzuki, M1
Cao, R; Dai, Q; Guo, X; Li, W; Wang, Z; Xu, Y; Yan, Y; Yin, J; Zhao, L; Zhong, W1
Cho, YM; Heo, J; Hong, B; Jeong, EM; Jeong, SM; Ju, H; Kim, Y; Lee, J; Lee, S; Lim, J; Nam, YJ; Ryu, CM; Shin, DM; Son, J; Yun, H1

Other Studies

51 other study(ies) available for thiazoles and ro 3306

ArticleYear
Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1.
    Proceedings of the National Academy of Sciences of the United States of America, 2006, Jul-11, Volume: 103, Issue:28

    Topics: Apoptosis; Catalysis; CDC2 Protein Kinase; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; HCT116 Cells; HeLa Cells; Humans; Mitosis; Quinolines; Thiazoles

2006
Cell cycle synchronization at the G2/M phase border by reversible inhibition of CDK1.
    Cell cycle (Georgetown, Tex.), 2006, Volume: 5, Issue:22

    Topics: Animals; CDC2 Protein Kinase; Cell Division; G2 Phase; Humans; Protein Kinase Inhibitors; Quinolines; Thiazoles

2006
Selective chemical inhibition as a tool to study Cdk1 and Cdk2 functions in the cell cycle.
    Cell cycle (Georgetown, Tex.), 2008, Jun-15, Volume: 7, Issue:12

    Topics: Animals; CDC2 Protein Kinase; Cell Cycle; Cells, Cultured; Cyclin-Dependent Kinase 2; DNA Replication; Humans; Ovum; Protein Kinase Inhibitors; Purines; Quinolines; Thiazoles; Xenopus

2008
Grapes(Chk1) prevents nuclear CDK1 activation by delaying cyclin B nuclear accumulation.
    The Journal of cell biology, 2008, Oct-06, Volume: 183, Issue:1

    Topics: Active Transport, Cell Nucleus; Animals; Aphidicolin; CDC2 Protein Kinase; Cell Cycle; Cell Cycle Proteins; Cell Nucleus; Cell Nucleus Division; Checkpoint Kinase 1; Cyclin B; Cycloheximide; Cytokinesis; Cytoplasm; Drosophila melanogaster; Drosophila Proteins; Embryo, Nonmammalian; Kinetochores; Mitosis; Mutation; Nuclear Envelope; Nuclear Proteins; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Purines; Quinolines; Recombinant Proteins; Roscovitine; Spindle Apparatus; Thiazoles

2008
Differentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activity.
    Genes & development, 2008, Nov-01, Volume: 22, Issue:21

    Topics: Animals; CDC2 Protein Kinase; Cell Cycle; Cell Differentiation; Cells, Cultured; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p57; Embryonic Stem Cells; Fibroblast Growth Factor 4; Giant Cells; Mice; Mice, Mutant Strains; Quinolines; Thiazoles; Trophoblasts

2008
Cyclin-dependent kinase 1 inhibitor RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AML.
    Cancer science, 2009, Volume: 100, Issue:6

    Topics: Apoptosis; bcl-2-Associated X Protein; CDC2 Protein Kinase; Cell Cycle; Cell Line, Tumor; HL-60 Cells; Humans; Leukemia, Promyelocytic, Acute; Mitochondria; Proto-Oncogene Proteins c-mdm2; Quinolines; RNA, Small Interfering; Thiazoles; Tumor Suppressor Protein p53

2009
Cyclin A2-cyclin-dependent kinase 2 cooperates with the PLK1-SCFbeta-TrCP1-EMI1-anaphase-promoting complex/cyclosome axis to promote genome reduplication in the absence of mitosis.
    Molecular and cellular biology, 2009, Volume: 29, Issue:24

    Topics: Anaphase-Promoting Complex-Cyclosome; Animals; CDC2 Protein Kinase; Cell Cycle Proteins; Cyclin A2; Cyclin-Dependent Kinase 2; DNA Replication; F-Box Proteins; HeLa Cells; Humans; Mitosis; Nuclear Proteins; Polo-Like Kinase 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Quinolines; Recombinant Fusion Proteins; SKP Cullin F-Box Protein Ligases; Thiazoles; Ubiquitin-Protein Ligase Complexes

2009
Differential roles of STIM1, STIM2 and Orai1 in the control of cell proliferation and SOCE amplitude in HEK293 cells.
    Cell calcium, 2010, Volume: 47, Issue:4

    Topics: Calcium Channels; CDC2 Protein Kinase; Cell Adhesion Molecules; Cell Line; Cell Proliferation; Humans; Hydroxyurea; Membrane Proteins; Neoplasm Proteins; Nucleic Acid Synthesis Inhibitors; ORAI1 Protein; Patch-Clamp Techniques; Quinolines; Receptor, Muscarinic M3; RNA, Small Interfering; Stromal Interaction Molecule 1; Stromal Interaction Molecule 2; Thiazoles; Transfection; TRPC Cation Channels

2010
Restoration of the tumor suppressor p53 by downregulating cyclin B1 in human papillomavirus 16/18-infected cancer cells.
    Oncogene, 2010, Oct-14, Volume: 29, Issue:41

    Topics: Blotting, Western; CDC2 Protein Kinase; Cell Line, Tumor; Cell Nucleus; Cyclin B1; DNA Damage; Down-Regulation; HCT116 Cells; HeLa Cells; Host-Pathogen Interactions; Human papillomavirus 16; Human papillomavirus 18; Humans; Mitosis; Neoplasms; Phosphorylation; Quinolines; RNA Interference; Serine; Thiazoles; Tumor Suppressor Protein p53

2010
Inhibition of dynamin by dynole 34-2 induces cell death following cytokinesis failure in cancer cells.
    Molecular cancer therapeutics, 2011, Volume: 10, Issue:9

    Topics: Acrylamides; Animals; Antimitotic Agents; Antineoplastic Agents; Apoptosis; Calcineurin Inhibitors; Cell Death; Cell Division; Cell Line, Tumor; Cytokinesis; Dynamins; Fibroblasts; HeLa Cells; HT29 Cells; Humans; Indoles; Mice; Neoplasms; Polyploidy; Protein Kinase Inhibitors; Quinolines; Thiazoles; Tubulin

2011
Two LXXLL motifs in the N terminus of Mps1 are required for Mps1 nuclear import during G(2)/M transition and sustained spindle checkpoint responses.
    Cell cycle (Georgetown, Tex.), 2011, Aug-15, Volume: 10, Issue:16

    Topics: Active Transport, Cell Nucleus; Amino Acid Motifs; Cell Cycle Proteins; Cell Division; Cell Line, Tumor; Chromosome Segregation; G2 Phase; Humans; Intracellular Signaling Peptides and Proteins; Kinetochores; M Phase Cell Cycle Checkpoints; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Quinolines; RNA Interference; RNA, Small Interfering; Signal Transduction; Spindle Apparatus; Thiazoles

2011
Cyclin B1 interacts with the BH3-only protein Bim and mediates its phosphorylation by Cdk1 during mitosis.
    Cell cycle (Georgetown, Tex.), 2011, Nov-15, Volume: 10, Issue:22

    Topics: Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; CDC2 Protein Kinase; Cell Cycle Checkpoints; Cell Line; Cyclin B1; Humans; K562 Cells; Membrane Proteins; Microtubules; Mitosis; Nocodazole; Paclitaxel; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Purines; Quinolines; RNA Interference; Thiazoles

2011
Forced mitotic entry of S-phase cells as a therapeutic strategy induced by inhibition of WEE1.
    Cancer discovery, 2012, Volume: 2, Issue:6

    Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Cycle Proteins; Cell Line; Cell Line, Tumor; Checkpoint Kinase 1; Cyclins; Deoxycytidine; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Female; Gemcitabine; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, SCID; Mitosis; Nuclear Proteins; Polycomb Repressive Complex 2; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Pyrimidinones; Quinolines; S Phase; Thiazoles; Thiophenes; Transcription Factors; Tumor Burden; Tumor Suppressor Protein p53; Urea; Xenograft Model Antitumor Assays

2012
Forced activation of Cdk1 via wee1 inhibition impairs homologous recombination.
    Oncogene, 2013, Jun-13, Volume: 32, Issue:24

    Topics: CDC2 Protein Kinase; Cell Cycle Proteins; DNA Damage; Enzyme Activation; Homologous Recombination; Humans; MCF-7 Cells; Nuclear Proteins; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Pyrimidinones; Quinolines; Thiazoles

2013
Inducing "cytokinesis" without mitosis in unfertilized Drosophila eggs.
    Cell cycle (Georgetown, Tex.), 2012, Aug-01, Volume: 11, Issue:15

    Topics: Actins; Animals; CDC2 Protein Kinase; Cell Division; Cells, Cultured; Contractile Proteins; Cyclin B; Cytokinesis; Drosophila; Drosophila Proteins; Embryo, Nonmammalian; GTPase-Activating Proteins; Microtubule-Associated Proteins; Mitosis; Myosins; Ovum; Protein Kinase Inhibitors; Purines; Quinolines; rhoA GTP-Binding Protein; Roscovitine; Spindle Apparatus; Thiazoles

2012
CDK1 differentially regulates G-overhang generation at leading- and lagging-strand telomeres in telomerase-negative cells in G2 phase.
    Cell cycle (Georgetown, Tex.), 2012, Aug-15, Volume: 11, Issue:16

    Topics: 2-Aminopurine; CDC2 Protein Kinase; Chromatin Immunoprecipitation; DNA; DNA Polymerase I; DNA Replication; Enzyme Activation; Enzyme Inhibitors; Flow Cytometry; G2 Phase; HeLa Cells; Humans; Quinolines; Telomerase; Telomere; Telomere-Binding Proteins; Thiazoles

2012
Clathrin-mediated endocytosis persists during unperturbed mitosis.
    Cell reports, 2013, Aug-29, Volume: 4, Issue:4

    Topics: Animals; Chlorocebus aethiops; Clathrin; Clathrin-Coated Vesicles; Cysteine; Endocytosis; HEK293 Cells; HeLa Cells; Hot Temperature; Humans; Mitosis; Nocodazole; Quinolines; Thiazoles; Transferrin

2013
Phosphorylation of eIF4GII and 4E-BP1 in response to nocodazole treatment: a reappraisal of translation initiation during mitosis.
    Cell cycle (Georgetown, Tex.), 2013, Dec-01, Volume: 12, Issue:23

    Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Antineoplastic Agents; CDC2 Protein Kinase; Cell Cycle Proteins; Cytokinesis; eIF-2 Kinase; Eukaryotic Initiation Factor-4G; HeLa Cells; Humans; Mass Spectrometry; Mitosis; Molecular Sequence Data; Nocodazole; Peptides; Phosphoproteins; Phosphorylation; Protein Structure, Tertiary; Quinolines; Sequence Alignment; Thiazoles; Tubulin

2013
IGF-1R inhibition enhances radiosensitivity and delays double-strand break repair by both non-homologous end-joining and homologous recombination.
    Oncogene, 2014, Nov-06, Volume: 33, Issue:45

    Topics: Animals; Apoptosis; Blotting, Western; Cell Cycle; Cell Line, Tumor; DNA Breaks, Double-Stranded; DNA End-Joining Repair; Fibroblasts; HEK293 Cells; Histones; Homologous Recombination; Humans; Isoxazoles; Mice, Knockout; Morpholines; Pyrimidines; Pyrones; Quinolines; Radiation Tolerance; Receptor, IGF Type 1; Recombinational DNA Repair; Thiazoles

2014
Cyclin-dependent kinase 1 inhibitor RO3306 promotes mitotic slippage in paclitaxel-treated HepG2 cells.
    Neoplasma, 2014, Volume: 61, Issue:1

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; CDC2 Protein Kinase; Cell Cycle; Drug Synergism; Gene Expression Profiling; Hep G2 Cells; Humans; Mitosis; Paclitaxel; Quinolines; Thiazoles

2014
ATR activates the S-M checkpoint during unperturbed growth to ensure sufficient replication prior to mitotic onset.
    Cell reports, 2013, Nov-27, Volume: 5, Issue:4

    Topics: Animals; Ataxia Telangiectasia Mutated Proteins; CDC2 Protein Kinase; Cell Death; Cell Line; Cell Proliferation; Chickens; Chromatids; Cytokinesis; DNA Replication; Gene Knockout Techniques; M Phase Cell Cycle Checkpoints; Quinolines; Replication Origin; Thiazoles

2013
A specific inhibitor of CDK1, RO-3306, reversibly arrests meiosis during in vitro maturation of porcine oocytes.
    Animal reproduction science, 2014, Jan-30, Volume: 144, Issue:3-4

    Topics: Animals; CDC2 Protein Kinase; Cells, Cultured; Female; In Vitro Oocyte Maturation Techniques; Meiosis; Oocytes; Oogenesis; Polyadenylation; Quinolines; Swine; Thiazoles

2014
The CDK1 inhibitor RO3306 improves the response of BRCA-proficient breast cancer cells to PARP inhibition.
    International journal of oncology, 2014, Volume: 44, Issue:3

    Topics: BRCA1 Protein; CDC2 Protein Kinase; Cell Line, Tumor; DNA Damage; Female; Gene Expression Regulation, Neoplastic; Homologous Recombination; Humans; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Quinolines; Thiazoles; Triple Negative Breast Neoplasms

2014
The α isoform of topoisomerase II is required for hypercompaction of mitotic chromosomes in human cells.
    Nucleic acids research, 2014, Volume: 42, Issue:7

    Topics: Antigens, Neoplasm; Catalytic Domain; Cell Line; Chromosomes, Human; DNA Topoisomerases, Type II; DNA-Binding Proteins; G2 Phase; Humans; Mitosis; Mutation; Protein Isoforms; Quinolines; Thiazoles

2014
Partial inhibition of Cdk1 in G 2 phase overrides the SAC and decouples mitotic events.
    Cell cycle (Georgetown, Tex.), 2014, Volume: 13, Issue:9

    Topics: CDC2 Protein Kinase; Centrosome; Cytokinesis; G2 Phase; HeLa Cells; Humans; Mitosis; Okadaic Acid; Phosphorylation; Polyploidy; Quinolines; Spindle Apparatus; Thiazoles

2014
Suppression of homologous recombination sensitizes human tumor cells to IGF-1R inhibition.
    International journal of cancer, 2015, Jun-15, Volume: 136, Issue:12

    Topics: Blotting, Western; Boron Compounds; BRCA1 Protein; BRCA2 Protein; CDC2 Protein Kinase; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; DNA Breaks, Double-Stranded; DNA Repair; Histones; Homologous Recombination; Humans; Isoxazoles; Male; Microscopy, Fluorescence; Phosphorylation; Prostatic Neoplasms; PTEN Phosphohydrolase; Pyrimidines; Quinolines; Rad51 Recombinase; Receptor, IGF Type 1; RNA Interference; Thiazoles

2015
Proteomic analysis of the response to cell cycle arrests in human myeloid leukemia cells.
    eLife, 2015, Jan-02, Volume: 4

    Topics: Cell Cycle Checkpoints; Cell Line, Tumor; Chromatin Assembly and Disassembly; Culture Media, Serum-Free; Humans; Hydroxyurea; Leukemia, Myeloid, Acute; Proteomics; Quinolines; Signal Transduction; Thiazoles

2015
Sensitivity to cdk1-inhibition is modulated by p53 status in preclinical models of embryonal tumors.
    Oncotarget, 2015, Jun-20, Volume: 6, Issue:17

    Topics: Apoptosis; Caspase 8; Caspase 9; CDC2 Protein Kinase; Cell Proliferation; Cell Survival; Cyclin B1; Cyclin-Dependent Kinases; Enzyme Activation; G2 Phase Cell Cycle Checkpoints; Humans; Infant; N-Myc Proto-Oncogene Protein; Neuroblastoma; Nuclear Proteins; Oncogene Proteins; Quinolines; Rhabdomyosarcoma; RNA Interference; RNA, Messenger; RNA, Small Interfering; Thiazoles; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2015
Control of timing of embryonic M-phase entry and exit is differentially sensitive to CDK1 and PP2A balance.
    The International journal of developmental biology, 2014, Volume: 58, Issue:10-12

    Topics: Animals; CDC2 Protein Kinase; Cell-Free System; Cyclin B2; Embryo, Nonmammalian; Embryonic Development; M Phase Cell Cycle Checkpoints; Mitosis; Okadaic Acid; Protein Phosphatase 2; Quinolines; Thiazoles; Xenopus laevis; Xenopus Proteins

2014
The lethal response to Cdk1 inhibition depends on sister chromatid alignment errors generated by KIF4 and isoform 1 of PRC1.
    Scientific reports, 2015, Oct-01, Volume: 5

    Topics: Alternative Splicing; Animals; CDC2 Protein Kinase; Cell Cycle Proteins; Cell Line; Cell Proliferation; Chromatids; Chromosomes, Human; Cyclin B; Cytokinesis; Humans; Kinesins; Mitosis; Protein Binding; Protein Isoforms; Quinolines; RNA Interference; RNA, Small Interfering; Spindle Apparatus; Thiazoles

2015
The role of APC/C(Cdh1) in replication stress and origin of genomic instability.
    Oncogene, 2016, 06-09, Volume: 35, Issue:23

    Topics: Antigens, CD; Cadherins; Cell Line, Tumor; Cyclin B; DNA Damage; DNA Replication; G1 Phase; Genomic Instability; Humans; Mitosis; Quinolines; S Phase; Thiazoles

2016
Cell proliferation potency is independent of FGF4 signaling in trophoblast stem cells derived from androgenetic embryos.
    The Journal of reproduction and development, 2016, Volume: 62, Issue:1

    Topics: Androgens; Animals; Cell Death; Cell Proliferation; Cell Survival; Female; Fibroblast Growth Factor 4; Gene Expression Regulation, Developmental; Genome; In Situ Hybridization; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mitosis; Quinolines; Signal Transduction; Stem Cells; Thiazoles; Trophoblasts

2016
Identification of Cyclin-Dependent Kinase 1 as a Novel Regulator of Type I Interferon Signaling in Systemic Lupus Erythematosus.
    Arthritis & rheumatology (Hoboken, N.J.), 2016, Volume: 68, Issue:5

    Topics: Adult; Animals; Blotting, Western; CDC2 Protein Kinase; Cyclin-Dependent Kinases; Female; Gene Expression Regulation; HeLa Cells; Humans; Interferon Type I; Kidney; Leukocytes, Mononuclear; Lupus Erythematosus, Systemic; Lupus Nephritis; Male; Mesangial Cells; Mice; Middle Aged; Phosphorylation; Quinolines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; STAT1 Transcription Factor; Thiazoles; Up-Regulation

2016
CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours.
    PloS one, 2016, Volume: 11, Issue:2

    Topics: Animals; Antineoplastic Agents; CDC2 Protein Kinase; Cell Line, Tumor; Colorectal Neoplasms; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Female; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Genes, Lethal; High-Throughput Screening Assays; Humans; Imidazoles; Mice; Mice, Inbred BALB C; Mice, Nude; Mutation; Pancreatic Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins p21(ras); Pyrimidines; Quinolines; RNA, Small Interfering; Signal Transduction; Survival Analysis; Thiazoles; Xenograft Model Antitumor Assays

2016
RO-3306 prevents postovulatory aging-mediated spontaneous exit from M-II arrest in rat eggs cultured in vitro.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2016, Volume: 78

    Topics: Aging; Animals; bcl-2-Associated X Protein; CDC2 Protein Kinase; Cell Shape; Cells, Cultured; Cyclin B1; Female; M Phase Cell Cycle Checkpoints; Metaphase; Oocytes; Ovulation; Phosphorylation; Phosphothreonine; Quinolines; Rats; Thiazoles

2016
Identification of Candidate Cyclin-dependent kinase 1 (Cdk1) Substrates in Mitosis by Quantitative Phosphoproteomics.
    Molecular & cellular proteomics : MCP, 2016, Volume: 15, Issue:7

    Topics: CDC2 Protein Kinase; Chromatography, Liquid; Cyclin-Dependent Kinases; Flavonoids; Gene Expression Regulation; HeLa Cells; Humans; Mitosis; Phosphoproteins; Piperidines; Protein Interaction Maps; Proteomics; Quinolines; Signal Transduction; Small Molecule Libraries; Tandem Mass Spectrometry; Thiazoles

2016
Jumping the nuclear envelop barrier: Improving polyplex-mediated gene transfection efficiency by a selective CDK1 inhibitor RO-3306.
    Journal of controlled release : official journal of the Controlled Release Society, 2016, 07-28, Volume: 234

    Topics: A549 Cells; CDC2 Protein Kinase; Cell Cycle; Cell Nucleus; DNA; Drug Carriers; Green Fluorescent Proteins; HeLa Cells; Humans; Nuclear Envelope; Polyethyleneimine; Protein Kinase Inhibitors; Quinolines; Thiazoles; Transfection

2016
Accumulation of cytoplasmic Cdk1 is associated with cancer growth and survival rate in epithelial ovarian cancer.
    Oncotarget, 2016, Aug-02, Volume: 7, Issue:31

    Topics: Animals; Apoptosis; Carcinoma, Ovarian Epithelial; CDC2 Protein Kinase; Cell Line, Tumor; Cisplatin; Cytoplasm; Female; Gene Expression Profiling; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Phosphorylation; Prognosis; Proportional Hazards Models; Quinolines; ROC Curve; Survival Rate; Thiazoles; Time Factors; Tissue Array Analysis; Treatment Outcome

2016
CDK1-PDK1-PI3K/Akt signaling pathway regulates embryonic and induced pluripotency.
    Cell death and differentiation, 2017, Volume: 24, Issue:1

    Topics: CDC2 Protein Kinase; Cell Differentiation; Cell Self Renewal; Cellular Reprogramming; Down-Regulation; Glycogen Synthase Kinase 3 beta; HEK293 Cells; Human Embryonic Stem Cells; Humans; Induced Pluripotent Stem Cells; Nanog Homeobox Protein; Octamer Transcription Factor-3; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Quinolines; RNA Interference; Signal Transduction; Thiazoles; Tretinoin

2017
Synchronization of HeLa Cells.
    Methods in molecular biology (Clifton, N.J.), 2017, Volume: 1524

    Topics: Cell Cycle; Cyclins; Flow Cytometry; G1 Phase; G2 Phase; HeLa Cells; Humans; Immunoblotting; Lovastatin; Nocodazole; Quinolines; S Phase; Thiazoles

2017
Residual Cdk1/2 activity after DNA damage promotes senescence.
    Aging cell, 2017, Volume: 16, Issue:3

    Topics: Antigens, CD; Cadherins; CDC2 Protein Kinase; Cell Line; Cell Line, Tumor; Cell Size; Cell Survival; Cellular Senescence; Cyclin B1; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; DNA Damage; Epithelial Cells; Etoposide; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation; Humans; Osteoblasts; Pteridines; Purines; Quinolines; Retinal Pigment Epithelium; Signal Transduction; Single-Cell Analysis; Thiazoles

2017
The High-Affinity Interaction between ORC and DNA that Is Required for Replication Licensing Is Inhibited by 2-Arylquinolin-4-Amines.
    Cell chemical biology, 2017, Aug-17, Volume: 24, Issue:8

    Topics: Adenosine Triphosphate; Allosteric Regulation; Amines; Animals; Cell Cycle Proteins; Cell Line, Tumor; Chromatin; DNA; DNA Replication; Humans; Minichromosome Maintenance Proteins; Nuclear Proteins; Origin Recognition Complex; Quinolines; Replication Origin; Thiazoles; Xenopus; Xenopus Proteins

2017
The requirement of Mettl3-promoted
    Open biology, 2017, Volume: 7, Issue:9

    Topics: 5' Untranslated Regions; Adenosine; Animals; Cell Differentiation; Cell Line; Cell Proliferation; ELAV-Like Protein 1; G2 Phase; Gene Expression Regulation; Methylation; Methyltransferases; Mice; Muscle Development; Muscle, Skeletal; Myoblasts; MyoD Protein; Quinolines; RNA, Small Interfering; S Phase; Signal Transduction; Thiazoles; Thymidine

2017
The closed form of Mad2 is bound to Mad1 and Cdc20 at unattached kinetochores.
    Cell cycle (Georgetown, Tex.), 2018, Volume: 17, Issue:9

    Topics: Anaphase; Antibodies, Monoclonal; Binding Sites; Cdc20 Proteins; Cell Cycle Proteins; G2 Phase Cell Cycle Checkpoints; HeLa Cells; Humans; Kinetochores; M Phase Cell Cycle Checkpoints; Mad2 Proteins; Nocodazole; Protein Folding; Quinolines; Thiazoles

2018
How Selective Are Pharmacological Inhibitors of Cell-Cycle-Regulating Cyclin-Dependent Kinases?
    Journal of medicinal chemistry, 2018, 10-25, Volume: 61, Issue:20

    Topics: Cell Cycle; Cyclin-Dependent Kinases; HCT116 Cells; Humans; Protein Kinase Inhibitors; Quinolines; Thiazoles

2018
TPX2 mediates prostate cancer epithelial-mesenchymal transition through CDK1 regulated phosphorylation of ERK/GSK3β/SNAIL pathway.
    Biochemical and biophysical research communications, 2021, 03-26, Volume: 546

    Topics: Animals; CDC2 Protein Kinase; Cell Cycle; Cell Cycle Proteins; Epithelial-Mesenchymal Transition; Glycogen Synthase Kinase 3 beta; Male; MAP Kinase Signaling System; Mice; Mice, Nude; Microtubule-Associated Proteins; Neoplasm Metastasis; Phosphorylation; Prognosis; Prostatic Neoplasms; Quinolines; Snail Family Transcription Factors; Thiazoles; Xenograft Model Antitumor Assays

2021
CDK1 inhibitor controls G2/M phase transition and reverses DNA damage sensitivity.
    Biochemical and biophysical research communications, 2021, 04-23, Volume: 550

    Topics: CDC2 Protein Kinase; Cell Division; Cell Line, Tumor; DNA Damage; G2 Phase Cell Cycle Checkpoints; Humans; Protein Kinase Inhibitors; Quinolines; Recombinational DNA Repair; Thiazoles

2021
Integrated Screens Identify CDK1 as a Therapeutic Target in Advanced Gastrointestinal Stromal Tumors.
    Cancer research, 2021, 05-01, Volume: 81, Issue:9

    Topics: Adult; Aged; Animals; Antineoplastic Agents; CDC2 Protein Kinase; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cohort Studies; Drug Resistance, Neoplasm; Female; Gastrointestinal Stromal Tumors; HEK293 Cells; Humans; Imatinib Mesylate; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Protein Kinase Inhibitors; Quinolines; Thiazoles; Transfection; Treatment Outcome; Tumor Burden; Xenograft Model Antitumor Assays

2021
Radiation-Induced Autophagy in Human Pancreatic Cancer Cells is Critically Dependent on G2 Checkpoint Activation: A Mechanism of Radioresistance in Pancreatic Cancer.
    International journal of radiation oncology, biology, physics, 2021, 09-01, Volume: 111, Issue:1

    Topics: Adenosine Triphosphate; Animals; Autophagy; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Female; G2 Phase Cell Cycle Checkpoints; Humans; Mice; Mice, Inbred BALB C; Pancreatic Neoplasms; Pyrazoles; Pyrimidinones; Quinolines; Radiation Tolerance; Thiazoles

2021
The CDK1 inhibitor, Ro-3306, is a potential antiviral candidate against influenza virus infection.
    Antiviral research, 2022, Volume: 201

    Topics: Antiviral Agents; CDC2 Protein Kinase; Humans; Influenza, Human; Orthomyxoviridae; Orthomyxoviridae Infections; Quinolines; Thiazoles; Viral Proteins; Virus Replication

2022
The CDK1/TFCP2L1/ID2 cascade offers a novel combination therapy strategy in a preclinical model of bladder cancer.
    Experimental & molecular medicine, 2022, Volume: 54, Issue:6

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apigenin; Apoptosis; CDC2 Protein Kinase; Cell Proliferation; Cyclin-Dependent Kinases; Humans; Inhibitor of Differentiation Protein 2; Quinolines; Repressor Proteins; Thiazoles; Transcription Factors; Urinary Bladder Neoplasms; Xenograft Model Antitumor Assays

2022