Page last updated: 2024-08-21

thiazoles and riluzole

thiazoles has been researched along with riluzole in 108 studies

Research

Studies (108)

Timeframe	Studies, this research(%)	All Research%
pre-1990	11 (10.19)	18.7374
1990's	88 (81.48)	18.2507
2000's	2 (1.85)	29.6817
2010's	5 (4.63)	24.3611
2020's	2 (1.85)	2.80

Authors

Authors	Studies
Chéramy, A; Desmonts, JM; Glowinski, J; Mantz, J; Thierry, AM	2
Blanchard, JC; Doble, A; Hubert, JP	1
Barbeito, L; Chéramy, A; Glowinski, J; Godeheu, G	1
Blin, O; Dusticier, N; Nieoullon, A; Samuel, D	1
Bardot, F; Blanchard, JC; Laduron, PM; Pratt, J; Rataud, J; Roux, M; Stutzmann, JM	1
Benoit, E; Escande, D	2
Gottesmann, C; Lazdunski, M; Romettino, S	1
Becquet, D; Faudon, M; Hery, F	1
Blanchard, JC; Böhme, GA; Gandolfo, G; Gottesmann, C; Laduron, PM; Lafforgue, J; Lazdunski, M; Stutzmann, JM	1
Artaud, F; Barbeito, L; Baruch, P; Chéramy, A; Glowinski, J; Godeheu, G	1
Doble, A; Hubert, JP	1
D'Angio, M; Scatton, B; Serrano, A	1
Blanchard, JC; Cintrat, P; Laduron, PM; Stutzmann, JM	1
Bardot, F; Blanchard, JC; Daniel, M; Laduron, PM; Malgouris, C; Pellis, F; Rataud, J; Uzan, A	1
Blanchard, JC; Laduron, PM; Lucas, M; Stutzmann, JM	1
Koek, W; Woods, JH	1
Baruch, P; Chéramy, A; Glowinski, J; Godeheu, G; Romo, R	1
Benavides, J; Camelin, JC; Flamand, F; Gueremy, C; Le Fur, G; Legrand, JJ; Mitrani, N; Uzan, A	1
Croucher, M; Gueremy, C; Le Fur, G; Legrand, JJ; Mazadier, M; Meldrum, B; Mizoule, J; Ollat, C; Uzan, A	1
Boireau, A; Bordier, F; Doble, A; Dubédat, P	1
Barbeito, L; Estevez, AG; Stutzmann, JM	1
Nightingale, SL	1
Canton, T; Debono, MW; Doble, A; Le Guern, J; Pradier, L	1
Boireau, A; Bordier, F; Doble, A; Dubédat, P; Durand, G; Meunier, M; Miquet, JM; Peny, C	1
Alaoui, F; Court, L; Pratt, J; Stutzmann, JM; Trocherie, S	1
Delumeau, JC; Doble, A; Glowinski, J; Hubert, JP; Prémont, J	1
Heurteaux, C; Lauritzen, I; Lazdunski, M; Widmann, C	1
Daniel, M; Doble, A; Malgouris, C	1
Bousseau, A; Couratier, P; Esclaire, F; Hugon, J; Sindou, P; Yardin, C	1
Boireau, A; Doble, A; Dubédat, P; Meunier, M; Miquet, JM	1
Rowland, LP	2
McRae, KD	1
Burgerman, RS	1
Murphy, JR	1
Rogawski, MA	1
Couratier, P; Esclaire, F; Hugon, J; Louvel, E; Sindou, P	1
Berlioz, S; Brée, F; Nguyen, P; Tillement, JP; Urien, S; Vacherot, F	1
Fuller, GN; McKee, P; Stevens, DL	1
Desmonts, JM; Henzel, D; Laudenbach, V; Lecharny, JB; Mantz, J	1
Ben-Ari, Y; Charriaut-Marlangue, C; Dessi, F	1
Martin, D; Nadler, JV; Thompson, MA	1
Drapeau, P; Dunn, RJ; Hebert, T; Pradier, L	1
Bensimon, G; Lacomblez, L; Meininger, V	1
Allix, M; Boulu, RG; Plotkine, M; Wahl, F	1
Benazzouz, A; Boireau, A; Boraud, T; Dubédat, P; Gross, C; Stutzmann, JM	1
Bensimon, G; Guillet, P; Lacomblez, L; Leigh, PN; Meininger, V	1
Emami, J; Goonetilleke, A; Guiloff, RJ	1
Martí-Fàbregas, J	1
Berger, AJ; Umemiya, M	1
Boraud, T; Gross, C; Pratt, J; Stutzmann, JM	1
Andrus, PK; Cutting, FB; Gurney, ME; Hall, ED; Zhai, P	1
Festoff, BW	1
Wokke, J	1
Mary, V; Stutzmann, JM; Wahl, F	1
Amagasu, SM; MacIver, MB; Mikulec, AA; Monroe, FA	1
Bouchard, JP; Duquette, P; Eisen, A; Gelinas, D; Harati, Y; Miller, RG; Munsat, TL; Powe, L; Rothstein, J; Salzman, P; Sufit, RL	1
Newman, D; Sufit, R	1
Hugon, J	1
Benfield, P; Bryson, HM; Fulton, B	1
Barnéoud, P; Boireau, A; Doble, A; Dubédat, P; Mazadier, M; Miquet, JM; Parmentier, S	1
Hobbs, GR; Riggs, JE	1
Doble, A	1
Bensimon, G; Delumeau, JC; Durrleman, S; Guillet, P; Lacomblez, L; Leigh, PN; Meininger, V; Powe, L	1
Barnes, S	1
Reynolds, DJ	1
Andrus, PK; Cutting, FB; Doble, A; Gurney, ME; Hall, ED; Taylor, CP; Zhai, P	1
Wokke, JH	1
Obrenovitch, TP	1
McIntosh, TK; Perri, BR; Smith, DH; Stutzmann, JM; Voddi, M	1
Klivényi, P; Vécsei, L	1
Moriwaka, F	1
Bansinath, M; Nivarthi, RN; Turndorf, H	1
Andersen, PM; Forsgren, L; Sojka, P	1
Bernardi, G; Bonci, A; Mercuri, NB; Siniscalchi, A	1
Klappenbach, G; Ludolph, AC; Riepe, MW	1
Shindo, M; Yanagisawa, N	1
Scarlato, G	1
Ince, PG; Shaw, PJ	1
Aubin, F; Dib, M; Jourdain, G; Meininger, V; Zeisser, P	1
Dengler, R; Tröger, M	1
Landis, BE; Wagner, ML	1
Mitsumoto, H	1
Mary, V; Renou, E; Stutzmann, JM; Wahl, F	1
Clark, W; Kendall, MJ	1
Barbeito, L; Estevez, A; Peluffo, H; Stutzmann, JM	1
Brouillet, E; Guyot, MC; Hantraye, P; Mary, V; Palfi, S; Peschanski, M; Riche, D; Stutzmann, JM; Wahl, F	1
Huang, CS; Nagata, K; Narahashi, T; Song, JH; Twombly, D; Yeh, JZ	1
Huang, CS; Nagata, K; Narahashi, T; Song, JH; Yeh, JZ	2
Bernardi, G; Spadoni, F; Stefani, A	1
Bournique, B; Martinet, M; Petry, M; Sanderink, GJ; Stevens, J	1
Audiau, F; Barreau, M; Blanchard, JC; Boireau, A; Bour, Y; Coléno, MA; Doble, A; Doerflinger, G; Donat, MH; Duchesne, JM; Ganil, P; Gontier, S; Guérémy, C; Honor, E; Hubert, P; Huu, CD; Jimonet, P; Just, B; Kerphirique, R; Laduron, PM; Le Blevec, J; Meunier, M; Mignani, S; Miquet, JM; Nemecek, C	1
Bloch, DA; Ciraulo, AM; Ciraulo, DA; Elkashef, A; Knapp, CM; Leiderman, DB; LoCastro, J; Montgomery, MA; Sarid-Segal, O	1
Barker, AL; Bates, GP; Beunard, JL; Hockly, E; Holt, K; Lowden, PA; Moffitt, H; Moolman, DL; Revington, AP; Sathasivam, K; Sunshine, S; Tse, J; Wanker, EE; Woodman, B	1
Deng, Y; Feng, W; Liu, W; Tian, Y; Xu, B; Xu, D; Xu, Z; Yang, H	1
Bruno, C; Camerino, DC; Carbonara, R; Cavalluzzi, MM; Costanza, T; Desaphy, JF; Franchini, C; Lentini, G	1
Carbonara, R; Conte Camerino, D; Costanza, T; Desaphy, JF	1
Altamura, C; Desaphy, JF; Farinato, A	1
Scott, A	1
van Den Berg, LH; van Eijk, RPA	1
Chen, JJ	1

Reviews

16 review(s) available for thiazoles and riluzole

Article	Year
Amyotrophic lateral sclerosis. Current opinion in neurology, 1994, Volume: 7, Issue:4 Topics: Amyotrophic Lateral Sclerosis; Clinical Trials as Topic; Excitatory Amino Acid Antagonists; Humans; Immunization, Passive; Motor Neuron Disease; Neurologic Examination; Riluzole; Thiazoles	1994
Pathogenic mechanisms in familial amyotrophic lateral sclerosis due to mutation of Cu, Zn superoxide dismutase. Pathologie-biologie, 1996, Volume: 44, Issue:1 Topics: Amyotrophic Lateral Sclerosis; Animals; Chromosome Aberrations; Chromosome Disorders; Chromosomes, Human, Pair 21; Excitatory Amino Acid Antagonists; Humans; Mice; Mice, Transgenic; Mutation; Riluzole; Superoxide Dismutase; Thiazoles; Vitamin E	1996
Amyotrophic lateral sclerosis: current and future treatment strategies. Drugs, 1996, Volume: 51, Issue:1 Topics: Amyotrophic Lateral Sclerosis; Apoptosis; Ciliary Neurotrophic Factor; Clinical Trials as Topic; Humans; Insulin-Like Growth Factor I; Nerve Tissue Proteins; Riluzole; Thiazoles	1996
Riluzole. Lancet (London, England), 1996, Sep-21, Volume: 348, Issue:9030 Topics: Amyotrophic Lateral Sclerosis; Animals; Drug Interactions; Female; Humans; Male; Middle Aged; Motor Neuron Disease; Neuroprotective Agents; Riluzole; Thiazoles	1996
Riluzole and ALS therapy. Wiener medizinische Wochenschrift (1946), 1996, Volume: 146, Issue:9-10 Topics: Amyotrophic Lateral Sclerosis; Double-Blind Method; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Motor Neurons; Neurologic Examination; Riluzole; Survival Analysis; Thiazoles	1996
Riluzole. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in amyotrophic lateral sclerosis. Drugs, 1996, Volume: 52, Issue:4 Topics: Administration, Oral; Animals; Antiparkinson Agents; Dose-Response Relationship, Drug; Double-Blind Method; Drug Tolerance; Excitatory Amino Acid Antagonists; Humans; In Vitro Techniques; Mice; Motor Neuron Disease; Multicenter Studies as Topic; Neuroprotective Agents; Randomized Controlled Trials as Topic; Riluzole; Sodium Channels; Thiazoles; Treatment Outcome	1996
The pharmacology and mechanism of action of riluzole. Neurology, 1996, Volume: 47, Issue:6 Suppl 4 Topics: Animals; Excitatory Amino Acid Antagonists; Rats; Riluzole; Thiazoles	1996
Sodium and potassium channel modulators: their role in neuroprotection. International review of neurobiology, 1997, Volume: 40 Topics: Animals; Benzeneacetamides; Cell Survival; Disease Models, Animal; Lamotrigine; Neurons; Neuroprotective Agents; Piperazines; Piperidines; Potassium Channels; Pyrimidines; Riluzole; Sodium Channels; Thiazoles; Triazines	1997
[Neurodegeneration: aging and dementia. Etiopathogenic role of electron transport disorders. Therapeutic possibilities]. Orvosi hetilap, 1997, Feb-09, Volume: 138, Issue:6 Topics: Aged; Aging; Alzheimer Disease; Calcium Channel Blockers; Cerebellar Diseases; Dementia; Electron Transport; Female; Humans; Huntington Disease; Lamotrigine; Male; Middle Aged; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Parkinson Disease; Riluzole; Thiazoles; Triazines	1997
[Amyotrophic lateral sclerosis]. [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 1997, Volume: 72, Issue:1 Topics: Adult; Amino Acids, Branched-Chain; Amyotrophic Lateral Sclerosis; Animals; Autoimmunity; Double-Blind Method; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Nerve Growth Factors; Nerve Tissue Proteins; Point Mutation; Randomized Controlled Trials as Topic; Riluzole; Superoxide Dismutase; Thiazoles; Threonine	1997
Glutamate, excitotoxicity and amyotrophic lateral sclerosis. Journal of neurology, 1997, Volume: 244 Suppl 2 Topics: Amyotrophic Lateral Sclerosis; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Neuroprotective Agents; Receptors, Glutamate; Riluzole; Thiazoles	1997
Impact of riluzole on the relationship between patient and physician. Journal of neurology, 1997, Volume: 244 Suppl 2 Topics: Amyotrophic Lateral Sclerosis; Attitude; Disease Progression; Emotions; Humans; Neuroprotective Agents; Physician-Patient Relations; Physicians; Riluzole; Thiazoles	1997
Riluzole: a new agent for amyotrophic lateral sclerosis. The Annals of pharmacotherapy, 1997, Volume: 31, Issue:6 Topics: Amyotrophic Lateral Sclerosis; Drug Interactions; Humans; Neuroprotective Agents; Randomized Controlled Trials as Topic; Riluzole; Thiazoles	1997
Therapeutic advances: riluzole for the treatment of motor neurone disease. Journal of clinical pharmacy and therapeutics, 1996, Volume: 21, Issue:6 Topics: Amyotrophic Lateral Sclerosis; Asthenia; Excitatory Amino Acid Antagonists; Health Care Costs; Humans; Quality of Life; Riluzole; Survivors; Thiazoles; Treatment Outcome	1996
Riluzole for amyotrophic lateral sclerosis. Drug and therapeutics bulletin, 1997, Volume: 35, Issue:2 Topics: Amyotrophic Lateral Sclerosis; Excitatory Amino Acid Antagonists; Humans; Neuroprotective Agents; Randomized Controlled Trials as Topic; Riluzole; Thiazoles	1997
Effects of Benzothiazolamines on Voltage-Gated Sodium Channels. Handbook of experimental pharmacology, 2018, Volume: 246 Topics: Animals; Humans; Myotonia; Piperidines; Riluzole; Thiazoles; Voltage-Gated Sodium Channels	2018

Trials

9 trial(s) available for thiazoles and riluzole

Article	Year
A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group. The New England journal of medicine, 1994, Mar-03, Volume: 330, Issue:9 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Follow-Up Studies; Humans; Male; Middle Aged; Prognosis; Proportional Hazards Models; Prospective Studies; Riluzole; Survival Analysis; Thiazoles; Treatment Outcome	1994
Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis/Riluzole Study Group II. Lancet (London, England), 1996, May-25, Volume: 347, Issue:9013 Topics: Amyotrophic Lateral Sclerosis; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neuroprotective Agents; Prognosis; Proportional Hazards Models; Riluzole; Survival Analysis; Thiazoles; Time Factors; Tracheostomy; Treatment Outcome	1996
Clinical trials of riluzole in patients with ALS. ALS/Riluzole Study Group-II. Neurology, 1996, Volume: 47, Issue:4 Suppl 2 Topics: Adult; Amyotrophic Lateral Sclerosis; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Liver; Male; Middle Aged; Neuroprotective Agents; Riluzole; Thiazoles	1996
Riluzole and ALS therapy. Wiener medizinische Wochenschrift (1946), 1996, Volume: 146, Issue:9-10 Topics: Amyotrophic Lateral Sclerosis; Double-Blind Method; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Motor Neurons; Neurologic Examination; Riluzole; Survival Analysis; Thiazoles	1996
A confirmatory dose-ranging study of riluzole in ALS. ALS/Riluzole Study Group-II. Neurology, 1996, Volume: 47, Issue:6 Suppl 4 Topics: Amyotrophic Lateral Sclerosis; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Humans; Male; Middle Aged; Riluzole; Survival Analysis; Thiazoles	1996
Effects of riluzole on symptom progression in amyotrophic lateral sclerosis. Lancet (London, England), 1997, Jan-18, Volume: 349, Issue:9046 Topics: Amyotrophic Lateral Sclerosis; Female; Humans; Male; Middle Aged; Neuroprotective Agents; Riluzole; Thiazoles	1997
Increase of flexor reflex latency in patients with amyotrophic lateral sclerosis treated with riluzole. Journal of neurology, neurosurgery, and psychiatry, 1997, Volume: 62, Issue:4 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Excitatory Amino Acid Antagonists; Female; Humans; Male; Middle Aged; Reaction Time; Reflex, Stretch; Riluzole; Thiazoles	1997
The Riluzole Early Access Programme: descriptive analysis of 844 patients in France. ALS/Riluzole Study Group III. Journal of neurology, 1997, Volume: 244 Suppl 2 Topics: Aged; Amyotrophic Lateral Sclerosis; Female; France; Humans; Male; Middle Aged; Neuroprotective Agents; Riluzole; Risk; Survival Analysis; Thiazoles; Time Factors; Tracheostomy; Treatment Failure; Treatment Outcome	1997
Efficacy screening trials of paroxetine, pentoxifylline, riluzole, pramipexole and venlafaxine in cocaine dependence. Addiction (Abingdon, England), 2005, Volume: 100 Suppl 1 Topics: Adolescent; Adult; Antidepressive Agents; Benzothiazoles; Cocaine-Related Disorders; Cyclohexanols; Dopamine Agonists; Double-Blind Method; Female; Humans; Male; Middle Aged; Neuroprotective Agents; Paroxetine; Pentoxifylline; Phosphodiesterase Inhibitors; Pramipexole; Riluzole; Selective Serotonin Reuptake Inhibitors; Thiazoles; Venlafaxine Hydrochloride	2005

Other Studies

84 other study(ies) available for thiazoles and riluzole

Article	Year
Anesthetic properties of riluzole (54274 RP), a new inhibitor of glutamate neurotransmission. Anesthesiology, 1992, Volume: 76, Issue:5 Topics: Anesthetics; Animals; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Glutamic Acid; Injections, Intraperitoneal; Ketamine; Male; Rats; Rats, Inbred Strains; Reflex, Abnormal; Riluzole; Sleep; Synaptic Transmission; Thiazoles; Thiopental	1992
Pertussis toxin pretreatment abolishes the inhibitory effect of riluzole and carbachol on D-[3H]aspartate release from cultured cerebellar granule cells. Neuroscience letters, 1992, Jun-22, Volume: 140, Issue:2 Topics: Anesthetics; Aspartic Acid; Carbachol; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Humans; Pertussis Toxin; Riluzole; Thiazoles; Virulence Factors, Bordetella	1992
Riluzole inhibits the release of glutamate in the caudate nucleus of the cat in vivo. Neuroscience letters, 1992, Dec-07, Volume: 147, Issue:2 Topics: Amino Acids; Anesthetics; Animals; Aspartic Acid; Calcium; Cats; Caudate Nucleus; Female; Glutamates; Glutamic Acid; Male; Potassium; Riluzole; Thiazoles	1992
Effects of riluzole (2-amino-6-trifluoromethoxy benzothiazole) on striatal neurochemical markers in the rat, with special reference to the dopamine, choline, GABA and glutamate synaptosomal high affinity uptake systems. Fundamental & clinical pharmacology, 1992, Volume: 6, Issue:4-5 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aspartic Acid; Biomarkers; Choline; Corpus Striatum; Culture Media; Dopamine; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hydroxyindoleacetic Acid; Neurotransmitter Uptake Inhibitors; Rats; Rats, Wistar; Riluzole; Serotonin; Synaptic Transmission; Synaptosomes; Thiazoles; Tritium	1992
Neuroprotective actions of riluzole in rodent models of global and focal cerebral ischaemia. Neuroscience letters, 1992, Jun-22, Volume: 140, Issue:2 Topics: Animals; Brain Ischemia; Disease Models, Animal; Electroencephalography; Gerbillinae; Ischemic Attack, Transient; Male; Rats; Riluzole; Thiazoles	1992
Riluzole specifically blocks inactivated Na channels in myelinated nerve fibre. Pflugers Archiv : European journal of physiology, 1991, Volume: 419, Issue:6 Topics: Animals; In Vitro Techniques; Kinetics; Models, Biological; Nerve Fibers; Potassium Channels; Rana esculenta; Ranvier's Nodes; Riluzole; Sodium Channels; Thiazoles	1991
Anticonvulsant and sleep-waking influences of riluzole in a rat model of absence epilepsy. European journal of pharmacology, 1991, Jul-09, Volume: 199, Issue:3 Topics: Animals; Anticonvulsants; Cerebral Cortex; Circadian Rhythm; Disease Models, Animal; Electromyography; Epilepsy, Absence; Male; Rats; Rats, Inbred Strains; Riluzole; Sleep; Thiazoles; Wakefulness	1991
In vivo evidence for an inhibitory glutamatergic control of serotonin release in the cat caudate nucleus: involvement of GABA neurons. Brain research, 1990, Jun-11, Volume: 519, Issue:1-2 Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Bicuculline; Cats; Caudate Nucleus; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Neurons; Riluzole; Serotonin; Spinal Cord; Synaptic Transmission; Tetrodotoxin; Thiazoles	1990
Riluzole prevents hyperexcitability produced by the mast cell degranulating peptide and dendrotoxin I in the rat. European journal of pharmacology, 1991, Feb-07, Volume: 193, Issue:2 Topics: 4-Aminopyridine; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Elapid Venoms; Electroencephalography; Hippocampus; Injections, Intraventricular; Male; Peptides; Rats; Rats, Inbred Strains; Riluzole; Seizures; Thiazoles	1991
Substance P and neurokinin A regulate by different mechanisms dopamine release from dendrites and nerve terminals of the nigrostriatal dopaminergic neurons. Neuroscience, 1988, Volume: 25, Issue:3 Topics: Animals; Cats; Corpus Striatum; Dendrites; Dopamine; Female; Glutamates; Glutamic Acid; Male; Nerve Endings; Neurokinin A; Neuropeptides; Riluzole; Substance P; Substantia Nigra; Thiazoles	1988
Ibotenic acid stimulates D-[3H]aspartate release from cultured cerebellar granule cells. Neuroscience letters, 1989, Jan-30, Volume: 96, Issue:3 Topics: Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Cerebellum; Ibotenic Acid; Oxazoles; Phosphoserine; Rats; Receptors, Amino Acid; Receptors, Cell Surface; Riluzole; Thiazoles	1989
[Anesthetic properties of a new inhibitor of glutaminergic transmission in the central nervous system, riluzole]. Annales francaises d'anesthesie et de reanimation, 1989, Volume: 8 Suppl Topics: Anesthetics; Animals; Central Nervous System; Glutamine; Male; Rats; Rats, Inbred Strains; Riluzole; Synaptic Transmission; Thiazoles	1989
NMDA antagonists block restraint-induced increase in extracellular DOPAC in rat nucleus accumbens. European journal of pharmacology, 1989, Mar-14, Volume: 162, Issue:1 Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic alpha-Antagonists; Animals; Aspartic Acid; Carbolines; Convulsants; Diazepam; Male; N-Methylaspartate; Nucleus Accumbens; Phenylacetates; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Restraint, Physical; Riluzole; Septal Nuclei; Thiazoles	1989
Riluzole antagonizes the anxiogenic properties of the beta-carboline FG 7142 in rats. Psychopharmacology, 1989, Volume: 99, Issue:4 Topics: Animals; Anti-Anxiety Agents; Appetite Depressants; Carbolines; Conditioning, Operant; Male; Rats; Rats, Inbred Strains; Riluzole; Thiazoles	1989
Riluzole, a novel antiglutamate, prevents memory loss and hippocampal neuronal damage in ischemic gerbils. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1989, Volume: 9, Issue:11 Topics: Amnesia; Animals; Avoidance Learning; Excitatory Amino Acid Antagonists; Female; Gerbillinae; Hippocampus; Ischemic Attack, Transient; Memory; Neurons; Quinuclidinyl Benzilate; Receptors, Muscarinic; Riluzole; Thiazoles	1989
Riluzole, a glutamate antagonist, enhances slow wave and REM sleep in rats. Neuroscience letters, 1988, May-26, Volume: 88, Issue:2 Topics: Animals; Dose-Response Relationship, Drug; Male; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Riluzole; Sleep; Sleep, REM; Thiazoles; Time Factors	1988
2-Amino-6-trifluoromethoxy benzothiazole (PK 26124), a proposed antagonist of excitatory amino acid neurotransmission, does not produce phencyclidine-like behavioral effects in pigeons, rats and rhesus monkeys. Neuropharmacology, 1988, Volume: 27, Issue:7 Topics: Animals; Behavior, Animal; Catalepsy; Columbidae; Discrimination Learning; Macaca mulatta; Male; Mephenesin; Phencyclidine; Rats; Rats, Inbred Strains; Riluzole; Species Specificity; Synaptic Transmission; Thiazoles	1988
In vivo presynaptic control of dopamine release in the cat caudate nucleus--II. Facilitatory or inhibitory influence of L-glutamate. Neuroscience, 1986, Volume: 19, Issue:4 Topics: Animals; Caudate Nucleus; Cerebral Cortex; Dopamine; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; Neural Pathways; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Riluzole; Synaptic Transmission; Tetrodotoxin; Thiazoles	1986
2-Amino-6-trifluoromethoxy benzothiazole, a possible antagonist of excitatory amino acid neurotransmission--II. Biochemical properties. Neuropharmacology, 1985, Volume: 24, Issue:11 Topics: Acetylcholine; Amino Acids; Animals; Anticonvulsants; Apomorphine; Cerebellum; Chlordiazepoxide; Cyclic GMP; Diazepam; gamma-Aminobutyric Acid; Harmaline; In Vitro Techniques; Injections, Intraventricular; Isoniazid; Male; Rats; Rats, Inbred Strains; Riluzole; Synaptic Transmission; Thiazoles	1985
2-Amino-6-trifluoromethoxy benzothiazole, a possible antagonist of excitatory amino acid neurotransmission--I. Anticonvulsant properties. Neuropharmacology, 1985, Volume: 24, Issue:8 Topics: Amino Acids; Animals; Anticonvulsants; Bicuculline; Electroshock; Female; Glutamate Decarboxylase; Harmaline; Male; Mice; Mice, Inbred DBA; Ouabain; Papio; Pentylenetetrazole; Picrotoxin; Rats; Riluzole; Seizures; Synaptic Transmission; Thiazoles	1985
Methamphetamine and dopamine neurotoxicity: differential effects of agents interfering with glutamatergic transmission. Neuroscience letters, 1995, Jul-28, Volume: 195, Issue:1 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemistry; Dizocilpine Maleate; Dopamine; Dopamine Agents; Excitatory Amino Acid Antagonists; Glutamic Acid; Lamotrigine; Male; Methamphetamine; Mice; Mice, Inbred Strains; Neostriatum; Neurons; Riluzole; Sodium Channels; Synaptic Transmission; Thiazoles; Triazines	1995
Protective effect of riluzole on excitatory amino acid-mediated neurotoxicity in motoneuron-enriched cultures. European journal of pharmacology, 1995, Jun-23, Volume: 280, Issue:1 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Survival; Cells, Cultured; Central Nervous System Diseases; Drug Interactions; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Kainic Acid; Motor Neurons; N-Methylaspartate; Rats; Receptors, Amino Acid; Riluzole; Thiazoles	1995
Riluzole for amyotrophic lateral sclerosis. The Medical letter on drugs and therapeutics, 1995, Dec-08, Volume: 37, Issue:963 Topics: Amyotrophic Lateral Sclerosis; Controlled Clinical Trials as Topic; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Muscles; Riluzole; Sodium Channels; Thiazoles; Tracheostomy; Treatment Outcome	1995
From the Food and Drug Administration. JAMA, 1995, Jul-26, Volume: 274, Issue:4 Topics: Amyotrophic Lateral Sclerosis; Drug Labeling; Drugs, Investigational; Humans; Product Surveillance, Postmarketing; Riluzole; Theophylline; Thiazoles; United States; United States Food and Drug Administration	1995
Inhibition by riluzole of electrophysiological responses mediated by rat kainate and NMDA receptors expressed in Xenopus oocytes. European journal of pharmacology, 1993, Apr-28, Volume: 235, Issue:2-3 Topics: 2-Amino-5-phosphonovalerate; Animals; Electrophysiology; Female; In Vitro Techniques; Ion Channels; Kainic Acid; Oocytes; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Riluzole; RNA, Messenger; Synaptic Transmission; Thiazoles; Xenopus laevis	1993
Riluzole and experimental parkinsonism: antagonism of MPTP-induced decrease in central dopamine levels in mice. Neuroreport, 1994, Dec-20, Volume: 5, Issue:18 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Dopamine; Homovanillic Acid; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Parkinson Disease, Secondary; Riluzole; Thiazoles	1994
Acute effects of irradiation on the rat brain: protection by glutamate blockade. European journal of pharmacology, 1995, Mar-24, Volume: 276, Issue:1-2 Topics: Amifostine; Animals; Brain; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Male; Motor Activity; Radiation-Protective Agents; Rats; Rats, Sprague-Dawley; Riluzole; Thiazoles	1995
Antagonism by riluzole of entry of calcium evoked by NMDA and veratridine in rat cultured granule cells: evidence for a dual mechanism of action. British journal of pharmacology, 1994, Volume: 113, Issue:1 Topics: Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Cerebellum; Cytosol; Excitatory Amino Acid Antagonists; Fluorescent Dyes; GTP-Binding Proteins; Indoles; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurons; Rats; Receptors, Glutamate; Riluzole; Sodium Channels; Spectrometry, Fluorescence; Thiazoles; Veratridine	1994
Glutamate-induced overexpression of NMDA receptor messenger RNAs and protein triggered by activation of AMPA/kainate receptors in rat hippocampus following forebrain ischemia. Brain research, 1994, Oct-03, Volume: 659, Issue:1-2 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Base Sequence; Brain Ischemia; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Male; Molecular Sequence Data; Oligonucleotide Probes; Prosencephalon; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Riluzole; RNA, Messenger; Thiazoles	1994
Neuroprotective effects of riluzole on N-methyl-D-aspartate- or veratridine-induced neurotoxicity in rat hippocampal slices. Neuroscience letters, 1994, Aug-15, Volume: 177, Issue:1-2 Topics: Animals; Cell Death; Female; Hippocampus; L-Lactate Dehydrogenase; Male; N-Methylaspartate; Nerve Tissue Proteins; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Riluzole; Sodium Channels; Thiazoles; Veratridine; Virulence Factors, Bordetella	1994
Prevention of HIV coat protein (gp120) toxicity in cortical cell cultures by riluzole. Journal of the neurological sciences, 1994, Volume: 126, Issue:2 Topics: Animals; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Antagonists; HIV Envelope Protein gp120; HIV-1; Nerve Degeneration; Neurons; Neuroprotective Agents; Peptide Fragments; Rats; Riluzole; Thiazoles	1994
Riluzole and experimental parkinsonism: partial antagonism of MPP(+)-induced increase in striatal extracellular dopamine in rats in vivo. Neuroreport, 1994, Oct-27, Volume: 5, Issue:16 Topics: 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Excitatory Amino Acid Antagonists; Extracellular Space; Homovanillic Acid; Male; Parkinson Disease, Secondary; Rats; Riluzole; Thiazoles	1994
Riluzole in amyotrophic lateral sclerosis. The New England journal of medicine, 1994, Jul-28, Volume: 331, Issue:4 Topics: Amyotrophic Lateral Sclerosis; Excitatory Amino Acid Antagonists; Humans; Research Design; Riluzole; Thiazoles	1994
Riluzole in amyotrophic lateral sclerosis. The New England journal of medicine, 1994, Jul-28, Volume: 331, Issue:4 Topics: Amyotrophic Lateral Sclerosis; Excitatory Amino Acid Antagonists; Humans; Riluzole; Thiazoles	1994
Riluzole in amyotrophic lateral sclerosis. The New England journal of medicine, 1994, Jul-28, Volume: 331, Issue:4 Topics: Amyotrophic Lateral Sclerosis; Clinical Trials as Topic; Excitatory Amino Acid Antagonists; Humans; Research Design; Riluzole; Thiazoles	1994
Riluzole in amyotrophic lateral sclerosis. The New England journal of medicine, 1994, Jul-28, Volume: 331, Issue:4 Topics: Amyotrophic Lateral Sclerosis; Excitatory Amino Acid Antagonists; Humans; Research Support as Topic; Riluzole; Thiazoles	1994
Neuroprotective effects of riluzole in ALS CSF toxicity. Neuroreport, 1994, Apr-14, Volume: 5, Issue:8 Topics: Amyotrophic Lateral Sclerosis; Animals; Cells, Cultured; Excitatory Amino Acid Antagonists; Humans; Neurons; Neurotoxins; Rats; Receptors, Glutamate; Riluzole; Thiazoles	1994
Characterization of discrete classes of binding sites of human serum albumin by application of thermodynamic principles. The Biochemical journal, 1994, Aug-15, Volume: 302 ( Pt 1) Topics: Benzothiazoles; Binding Sites; Humans; Isradipine; Ligands; Riluzole; Serum Albumin; Sulfonamides; Thermodynamics; Thiazoles	1994
Riluzole in amyotrophic lateral sclerosis. The New England journal of medicine, 1994, Jul-28, Volume: 331, Issue:4 Topics: Amyotrophic Lateral Sclerosis; Excitatory Amino Acid Antagonists; Humans; Riluzole; Thiazoles	1994
Riluzole, a novel antiglutamate, blocks GABA uptake by striatal synaptosomes. European journal of pharmacology, 1994, May-12, Volume: 257, Issue:1-2 Topics: Animals; Corpus Striatum; Excitatory Amino Acid Antagonists; GABA Antagonists; Male; Rats; Rats, Wistar; Riluzole; Synaptosomes; Thiazoles	1994
Riluzole prevents anoxic injury in cultured cerebellar granule neurons. European journal of pharmacology, 1993, Dec-07, Volume: 250, Issue:2 Topics: Animals; Cells, Cultured; Cerebellum; Hypoxia, Brain; Nerve Degeneration; Neurons; Rats; Riluzole; Synaptic Transmission; Thiazoles	1993
The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CA1. European journal of pharmacology, 1993, Dec-21, Volume: 250, Issue:3 Topics: Animals; Aspartic Acid; Excitatory Amino Acid Antagonists; Female; gamma-Aminobutyric Acid; Glutamates; Hippocampus; Potassium; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Riluzole; Thiazoles	1993
Block of the rat brain IIA sodium channel alpha subunit by the neuroprotective drug riluzole. Molecular pharmacology, 1994, Volume: 45, Issue:5 Topics: Animals; Brain Ischemia; Models, Neurological; Neuropeptides; Oocytes; Rats; Riluzole; Sodium Channel Blockers; Sodium Channels; Thiazoles; Xenopus	1994
Riluzole for the treatment of amyotrophic lateral sclerosis--too soon to tell? The New England journal of medicine, 1994, Mar-03, Volume: 330, Issue:9 Topics: Amyotrophic Lateral Sclerosis; Excitatory Amino Acid Antagonists; Humans; Riluzole; Thiazoles	1994
Effect of riluzole on focal cerebral ischemia in rats. European journal of pharmacology, 1993, Jan-12, Volume: 230, Issue:2 Topics: Anesthetics; Animals; Avoidance Learning; Blood Pressure; Brain; Brain Ischemia; Male; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Riluzole; Thiazoles	1993
Fast K channels are more sensitive to riluzole than slow K channels in myelinated nerve fibre. Pflugers Archiv : European journal of physiology, 1993, Volume: 422, Issue:5 Topics: Anesthetics; Animals; In Vitro Techniques; Nerve Fibers, Myelinated; Potassium Channels; Potassium Chloride; Psychotropic Drugs; Rana esculenta; Ranvier's Nodes; Riluzole; Sciatic Nerve; Thiazoles	1993
Riluzole prevents MPTP-induced parkinsonism in the rhesus monkey: a pilot study. European journal of pharmacology, 1995, Sep-25, Volume: 284, Issue:3 Topics: Animals; Antiparkinson Agents; Dopamine; Electromyography; Excitatory Amino Acid Antagonists; Macaca mulatta; MPTP Poisoning; Muscle Rigidity; Neuroprotective Agents; Parkinson Disease, Secondary; Pilot Projects; Riluzole; Sodium Channels; Thiazoles	1995
Riluzole and amyotrophic lateral sclerosis. Lancet (London, England), 1996, Aug-03, Volume: 348, Issue:9023 Topics: Amyotrophic Lateral Sclerosis; Clinical Trials as Topic; Humans; Neuroprotective Agents; Patient Dropouts; Proportional Hazards Models; Reproducibility of Results; Riluzole; Risk; Thiazoles	1996
[Riluzole for everybody or for nobody]. Neurologia (Barcelona, Spain), 1996, Volume: 11, Issue:1 Topics: Amyotrophic Lateral Sclerosis; Excitatory Amino Acid Antagonists; Humans; Riluzole; Thiazoles	1996
Inhibition by riluzole of glycinergic postsynaptic currents in rat hypoglossal motoneurones. British journal of pharmacology, 1995, Volume: 116, Issue:8 Topics: Animals; Animals, Newborn; Glycine Agents; Hypoglossal Nerve; In Vitro Techniques; Ion Channels; Motor Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Riluzole; Synaptic Transmission; Tetrodotoxin; Thiazoles	1995
The effect of riluzole on post-traumatic spinal cord injury in the rat. Neuroreport, 1996, Jan-31, Volume: 7, Issue:2 Topics: Anesthesia; Animals; Evoked Potentials, Somatosensory; Hemorrhage; Male; Neuroprotective Agents; Paralysis; Rats; Rats, Wistar; Riluzole; Spinal Cord; Spinal Cord Compression; Thiazoles; Time Factors	1996
Effect of riluzole on quinolinate-induced neuronal damage in rats: comparison with blockers of glutamatergic neurotransmission. Neuroscience letters, 1995, Dec-01, Volume: 201, Issue:1 Topics: Animals; Anticonvulsants; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Lamotrigine; Male; Neurons; Quinolinic Acid; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Riluzole; Synaptic Transmission; Thiazoles; Triazines	1995
Riluzole anesthesia: use-dependent block of presynaptic glutamate fibers. Anesthesiology, 1996, Volume: 85, Issue:3 Topics: Action Potentials; Anesthetics; Animals; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Male; Rats; Rats, Sprague-Dawley; Riluzole; Sodium Channel Blockers; Synaptic Transmission; Thiazoles	1996
The impact of the approval of riluzole. Neurology, 1996, Volume: 47, Issue:4 Suppl 2 Topics: Amyotrophic Lateral Sclerosis; Humans; Neuroprotective Agents; Riluzole; Thiazoles	1996
Rilutek (Riluzole) may extend survival in amyotrophic lateral sclerosis. The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses, 1996, Volume: 28, Issue:4 Topics: Amyotrophic Lateral Sclerosis; Double-Blind Method; Humans; Neuroprotective Agents; Randomized Controlled Trials as Topic; Riluzole; Survival Analysis; Thiazoles; Tracheostomy	1996
Neuroprotective effects of riluzole on a model of Parkinson's disease in the rat. Neuroscience, 1996, Volume: 74, Issue:4 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amphetamine; Animals; Apomorphine; Brain Chemistry; Central Nervous System Stimulants; Conditioning, Operant; Dopamine Agonists; Female; Male; Neuroprotective Agents; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Inbred Strains; Riluzole; Stereotyped Behavior; Substantia Nigra; Sympatholytics; Thiazoles	1996
Riluzole and amyotrophic lateral sclerosis: did potential market size bias pharmaceutical research? Archives of neurology, 1996, Volume: 53, Issue:11 Topics: Amyotrophic Lateral Sclerosis; Drug Industry; Humans; Neuroprotective Agents; Riluzole; Thiazoles	1996
Riluzole. Lancet (London, England), 1996, Dec-14, Volume: 348, Issue:9042 Topics: Aged; Amyotrophic Lateral Sclerosis; Clinical Trials as Topic; Humans; Neuroprotective Agents; Publishing; Riluzole; Thiazoles	1996
Riluzole. Lancet (London, England), 1996, Dec-14, Volume: 348, Issue:9042 Topics: Humans; Motor Neuron Disease; Neuroprotective Agents; Prognosis; Riluzole; Thiazoles	1996
Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis. Annals of neurology, 1996, Volume: 39, Issue:2 Topics: Acetates; Amines; Amyotrophic Lateral Sclerosis; Animals; Brain; Cyclohexanecarboxylic Acids; Diet; Disease Progression; Gabapentin; gamma-Aminobutyric Acid; Humans; Mice; Mice, Transgenic; Oxidative Stress; Riluzole; Spinal Cord; Superoxide Dismutase; Survival Analysis; Thiazoles; Vitamin E	1996
[Riluzole treatment in amyotrophic lateral sclerosis]. Nederlands tijdschrift voor geneeskunde, 1996, Nov-16, Volume: 140, Issue:46 Topics: Amyotrophic Lateral Sclerosis; Controlled Clinical Trials as Topic; Drug Costs; Excitatory Amino Acid Antagonists; Humans; Neuroprotective Agents; Riluzole; Thiazoles	1996
Riluzole, a novel neuroprotective agent, attenuates both neurologic motor and cognitive dysfunction following experimental brain injury in the rat. Journal of neurotrauma, 1996, Volume: 13, Issue:12 Topics: Animals; Body Water; Brain Edema; Brain Injuries; Cognition Disorders; Male; Movement Disorders; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Riluzole; Thiazoles	1996
Role of nitric oxide-mediated signal transduction in hypothermia induced by intravenous anesthetics. Annals of the New York Academy of Sciences, 1997, Mar-15, Volume: 813 Topics: Anesthetics, Intravenous; Animals; Cerebellum; Cyclic GMP; Hypothermia; Ketamine; Mice; Nitric Oxide; Nitric Oxide Synthase; Pentobarbital; Proto-Oncogene Proteins c-fos; Riluzole; Signal Transduction; Thiazoles	1997
Effects of riluzole on rat cortical neurones: an in vitro electrophysiological study. British journal of pharmacology, 1997, Volume: 120, Issue:2 Topics: Action Potentials; Animals; Calcium; Cerebral Cortex; Glutamic Acid; In Vitro Techniques; Male; Neuroprotective Agents; Rats; Rats, Wistar; Riluzole; Thiazoles	1997
[Neuroprotective therapy for amyotrophic lateral sclerosis (ALS)]. Rinsho shinkeigaku = Clinical neurology, 1996, Volume: 36, Issue:12 Topics: Amyotrophic Lateral Sclerosis; Humans; Neuroprotective Agents; Riluzole; Thiazoles	1996
Amyotrophic lateral sclerosis: from pathological mechanisms to patient care. Journal of neurology, 1997, Volume: 244 Suppl 2 Topics: Amyotrophic Lateral Sclerosis; Animals; Excitatory Amino Acid Antagonists; Humans; Neuroprotective Agents; Point Mutation; Riluzole; Superoxide Dismutase; Thiazoles	1997
Riluzole--what is its impact in our treatment and understanding of amyotrophic lateral sclerosis? The Annals of pharmacotherapy, 1997, Volume: 31, Issue:6 Topics: Amyotrophic Lateral Sclerosis; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Humans; Neuroprotective Agents; Riluzole; Thiazoles	1997
Riluzole reduces brain lesions and improves neurological function in rats after a traumatic brain injury. Brain research, 1997, May-09, Volume: 756, Issue:1-2 Topics: Animals; Brain; Brain Injuries; Male; Neurologic Examination; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Riluzole; Thiazoles; Wounds, Nonpenetrating	1997
Riluzole promotes survival of rat motoneurons in vitro by stimulating trophic activity produced by spinal astrocyte monolayers. Neuroscience letters, 1997, Jun-13, Volume: 228, Issue:3 Topics: Animals; Astrocytes; Cell Survival; Cells, Cultured; Culture Media, Conditioned; DNA; Immunohistochemistry; Leucine; Motor Neurons; Nerve Tissue Proteins; Neuroprotective Agents; Rats; Receptors, Nerve Growth Factor; Riluzole; Spinal Cord; Thiazoles; Thymidine	1997
Riluzole reduces incidence of abnormal movements but not striatal cell death in a primate model of progressive striatal degeneration. Experimental neurology, 1997, Volume: 146, Issue:1 Topics: Acetylcholinesterase; Animals; Antiparkinson Agents; Apomorphine; Caudate Nucleus; Corpus Striatum; Movement Disorders; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Nitro Compounds; Papio; Parkinson Disease, Secondary; Propionates; Putamen; Riluzole; Thiazoles	1997
G-proteins are involved in riluzole inhibition of high voltage-activated calcium channels in rat dorsal root ganglion neurons. Brain research, 1997, Jul-11, Volume: 762, Issue:1-2 Topics: Animals; Animals, Newborn; Calcium Channels; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Ethylmaleimide; Ganglia, Spinal; GTP-Binding Proteins; Guanosine Diphosphate; Ion Channel Gating; Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Riluzole; Thiazoles; Thionucleotides; Virulence Factors, Bordetella	1997
Differential action of riluzole on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 282, Issue:2 Topics: Animals; Female; Ganglia, Spinal; In Vitro Techniques; Kinetics; Male; Neurons; Neuroprotective Agents; Rats; Riluzole; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin; Thiazoles	1997
Differential inhibition by riluzole, lamotrigine, and phenytoin of sodium and calcium currents in cortical neurons: implications for neuroprotective strategies. Experimental neurology, 1997, Volume: 147, Issue:1 Topics: Animals; Anticonvulsants; Calcium; Calcium Channel Blockers; Cerebral Cortex; Electric Conductivity; Excitatory Amino Acid Antagonists; Lamotrigine; Male; Neurons; Neuroprotective Agents; Phenytoin; Rats; Rats, Wistar; Riluzole; Sodium; Thiazoles; Triazines	1997
Practice advisory on the treatment of amyotrophic lateral sclerosis with riluzole: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology, 1997, Volume: 49, Issue:3 Topics: Amyotrophic Lateral Sclerosis; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Excitatory Amino Acid Antagonists; Humans; Neurology; Riluzole; Societies, Medical; Thiazoles; Treatment Outcome	1997
Effects of the neuroprotective agent riluzole on the high voltage-activated calcium channels of rat dorsal root ganglion neurons. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 282, Issue:3 Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Calcium Channels; Dose-Response Relationship, Drug; Ganglia, Spinal; Neuroprotective Agents; Nimodipine; Rats; Rats, Sprague-Dawley; Riluzole; Thiazoles	1997
Involvement of human CYP1A isoenzymes in the metabolism and drug interactions of riluzole in vitro. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 282, Issue:3 Topics: Biotransformation; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Glucuronates; Humans; Isoenzymes; Male; Neuroprotective Agents; Oxidation-Reduction; Riluzole; Thiazoles	1997
Riluzole series. Synthesis and in vivo "antiglutamate" activity of 6-substituted-2-benzothiazolamines and 3-substituted-2-imino-benzothiazolines. Journal of medicinal chemistry, 1999, Jul-29, Volume: 42, Issue:15 Topics: Animals; Benzothiazoles; Excitatory Amino Acid Antagonists; Glutamic Acid; Hypoxia; Imines; Injections, Intraventricular; Male; Mice; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Riluzole; Seizures; Structure-Activity Relationship; Sulfoxides; Thiazoles	1999
Evaluation of the benzothiazole aggregation inhibitors riluzole and PGL-135 as therapeutics for Huntington's disease. Neurobiology of disease, 2006, Volume: 21, Issue:1 Topics: Animals; Benzothiazoles; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Genotype; Huntington Disease; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Neuroprotective Agents; Organ Culture Techniques; Riluzole; Thiazoles	2006
G0/G1 phase arrest and apoptosis induced by manganese chloride on cultured rat astrocytes and protective effects of riluzole. Biological trace element research, 2011, Volume: 144, Issue:1-3 Topics: Animals; Animals, Newborn; Apoptosis; Astrocytes; Cell Cycle; Cell Cycle Checkpoints; Cell Survival; Cells, Cultured; Chlorides; Coloring Agents; Dose-Response Relationship, Drug; Flow Cytometry; G1 Phase; L-Lactate Dehydrogenase; Manganese Compounds; Manganese Poisoning; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Resting Phase, Cell Cycle; Riluzole; Tetrazolium Salts; Thiazoles	2011
Molecular dissection of lubeluzole use-dependent block of voltage-gated sodium channels discloses new therapeutic potentials. Molecular pharmacology, 2013, Volume: 83, Issue:2 Topics: Anesthetics, Local; Binding Sites; Cell Line; HEK293 Cells; Humans; Membrane Potentials; Membrane Proteins; Mutation; NAV1.4 Voltage-Gated Sodium Channel; Neuroprotective Agents; Piperidines; Protein Binding; Protein Interaction Domains and Motifs; Protein Isoforms; Riluzole; Sodium Channel Blockers; Thiazoles	2013
Preclinical evaluation of marketed sodium channel blockers in a rat model of myotonia discloses promising antimyotonic drugs. Experimental neurology, 2014, Volume: 255 Topics: Animals; Carbamazepine; Disease Models, Animal; Flecainide; HEK293 Cells; Humans; Mexiletine; Muscle, Skeletal; Myotonia Congenita; Orphenadrine; Piperidines; Propafenone; Rats; Rats, Wistar; Riluzole; Sodium Channel Blockers; Thiazoles	2014
Drug therapy: On the treatment trail for ALS. Nature, 2017, 10-18, Volume: 550, Issue:7676 Topics: Amyotrophic Lateral Sclerosis; Antipyrine; Benzamides; C9orf72 Protein; Clinical Trials as Topic; Disease Progression; Drug Therapy, Combination; Edaravone; Genetic Therapy; Humans; Imidazoles; Mesenchymal Stem Cells; Motor Neurons; Neuroglia; Off-Label Use; Oligoribonucleotides, Antisense; Piperidines; Precision Medicine; Pyrazines; Pyridines; Riluzole; RNAi Therapeutics; Stem Cell Transplantation; Superoxide Dismutase; Thiazoles; United States; United States Food and Drug Administration	2017
In pursuit of the normal progressor: the holy grail for ALS clinical trial design? Amyotrophic lateral sclerosis & frontotemporal degeneration, 2020, Volume: 21, Issue:1-2 Topics: Amyotrophic Lateral Sclerosis; Benzamides; Clinical Trials as Topic; Humans; Piperidines; Pyridines; Riluzole; Thiazoles	2020
Overview of current and emerging therapies for amytrophic lateral sclerosis. The American journal of managed care, 2020, Volume: 26, Issue:9 Suppl Topics: Amyotrophic Lateral Sclerosis; Antibodies, Monoclonal, Humanized; Benzamides; Edaravone; Humans; Mesenchymal Stem Cells; Oligonucleotides; Piperidines; Pyridines; Riluzole; Thiazoles	2020