Page last updated: 2024-08-21

thiazoles and repinotan hydrochloride

thiazoles has been researched along with repinotan hydrochloride in 35 studies

Research

Studies (35)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	11 (31.43)	18.2507
2000's	22 (62.86)	29.6817
2010's	2 (5.71)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
De Vry, J; Glaser, T; Greuel, JM; Heine, HG; Mauler, F; Schmidt, B; Schohe-Loop, R; Sommermeyer, H	1
Blier, P; de Montigny, C; Dong, J	1
Fahrig, T; Struppeck, H; Suchanek, B	1
De Vry, J; Jentzsch, KR	1
Krieglstein, J; Semkova, I; Wolz, P	1
Adell, A; Artigas, F	1
Ahlemeyer, B; Glaser, A; Krieglstein, J; Schaper, C; Semkova, I	1
Fujii, T; Kawashima, K; Koyama, T; Nakajima, Y	1
Artigas, F; Casanovas, JM; Hervás, I	1
Alessandri, B; Bullock, RM; Tsuchida, E	1
Ahlemeyer, B; Beier, H; Krieglstein, J; Schaper, C; Semkova, I	1
Artigas, F; Berton, O; Casanovas, JM; Celada, P	1
Culmsee, C; Kouklei, M; Krieglstein, J; Schaper, C; Zhu, Y	1
Fahrig, T; Horváth, E; Jork, R; Mauler, F	1
Dixon, CE; Horváth, E; Kline, AE; Marion, DW; Yu, J	1
Becker, A; Krieglstein, J; Kukley, M; Rose, K; Schaper, C	1
Harkany, T; Horvath, KM; Keijser, J; Luiten, PG; Mulder, J; Nyakas, C; van der Meeberg, EK	1
Braakman, R; Legout, V; Ohman, J	1
Lutsep, HL	2
Adayev, T; Banerjee, P; Ray, I; Sobocki, T; Sondhi, R	1
Adell, A; Amargós-Bosch, M; Artigas, F; Bortolozzi, A; Díaz-Mataix, L; Pons, S; Serrats, J	1
Horváth, E; Mauler, F	1
Boettcher, M; Heinig, R; Kuhlmann, J; Wensing, G	1
Silver, FL; Simard, D; Teal, P	1
Beckermann, B; Buehner, K; Mauler, F; Schuhmacher, J; Schwarz, T; Seidel, D; Steinke, W; Weinz, C; Zimmerd, D	1
Artigas, F; Celada, P; Díaz-Mataix, L	1
Artigas, F; Bortolozzi, A; Celada, P; Díaz-Mataix, L; Scorza, MC; Toth, M	1
Bezard, E; Gerlach, I; Gross, CE; Jork, R; Moratalla, R	1
Heinig, R; Higuchi, S; Kuroki, Y; Tanigawa, T	1
Berends, AC; Luiten, PG; Nyakas, C	1
Davis, S; Fierus, M; Hacke, W; Kaste, M; Lyden, PD; Teal, P	1
Boettcher, MF; Guenther, U; Hoeft, A; Putensen, C; Theuerkauf, N; Wensing, G; Wrigge, H; Zinserling, J	1
Boettcher, MF; Guenther, U; Hoeft, A; Huse, D; Putensen, C; Theuerkauf, NU; Wensing, G	1

Reviews

3 review(s) available for thiazoles and repinotan hydrochloride

Article	Year
Repinotan Bayer. Current opinion in investigational drugs (London, England : 2000), 2002, Volume: 3, Issue:6 Topics: Animals; Benzopyrans; Brain Injuries; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Drug Evaluation, Preclinical; Humans; Lethal Dose 50; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Stroke; Structure-Activity Relationship; Thiazoles	2002
Repinotan, A 5-HT1A agonist, in the treatment of acute ischemic stroke. Current drug targets. CNS and neurological disorders, 2005, Volume: 4, Issue:2 Topics: Acute Disease; Aged; Benzopyrans; Brain Ischemia; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Neuroprotective Agents; Serotonin Receptor Agonists; Stroke; Thiazoles; Treatment Outcome	2005
A review of the neuroprotective properties of the 5-HT1A receptor agonist repinotan HCl (BAYx3702) in ischemic stroke. CNS drug reviews, 2005,Winter, Volume: 11, Issue:4 Topics: Animals; Benzopyrans; Disease Models, Animal; Glutamic Acid; Humans; Models, Biological; Nerve Growth Factors; Neuroprotective Agents; Piperazines; Pyridines; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Serotonin 5-HT1 Receptor Agonists; Signal Transduction; Stroke; Thiazoles	2005

Trials

4 trial(s) available for thiazoles and repinotan hydrochloride

Article	Year
Repinotan (BAY x 3702): a 5HT1A agonist in traumatically brain injured patients. Journal of neurotrauma, 2001, Volume: 18, Issue:12 Topics: Adolescent; Adult; Aged; Benzopyrans; Blood Pressure; Brain Injuries; Double-Blind Method; Female; Humans; Male; Middle Aged; Patients; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Thiazoles; Treatment Outcome	2001
The BRAINS study: safety, tolerability, and dose-finding of repinotan in acute stroke. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2005, Volume: 32, Issue:1 Topics: Aged; Benzopyrans; Humans; Infusions, Intravenous; Serotonin Receptor Agonists; Stroke; Thiazoles; Treatment Outcome	2005
Evaluation of interethnic differences in repinotan pharmacokinetics by using population approach. Drug metabolism and pharmacokinetics, 2006, Volume: 21, Issue:1 Topics: Adult; Aged; Asian People; Benzopyrans; Body Weight; Brain Injuries; Ethnicity; Female; Humans; Male; Middle Aged; Models, Statistical; Population; Serotonin Receptor Agonists; Sex Characteristics; Thiazoles; White People	2006
A randomized, double-blind, placebo-controlled trial to evaluate the efficacy, safety, tolerability, and pharmacokinetic/pharmacodynamic effects of a targeted exposure of intravenous repinotan in patients with acute ischemic stroke: modified Randomized Ex Stroke, 2009, Volume: 40, Issue:11 Topics: Aged; Aged, 80 and over; Benzopyrans; Brain Ischemia; Dose-Response Relationship, Drug; Double-Blind Method; Drug Delivery Systems; Female; Humans; Infusions, Intravenous; Internationality; Male; Middle Aged; Stroke; Thiazoles	2009

Other Studies

28 other study(ies) available for thiazoles and repinotan hydrochloride

Article	Year
Characterization of the aminomethylchroman derivative BAY x 3702 as a highly potent 5-hydroxytryptamine1A receptor agonist. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 284, Issue:3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Adrenocorticotropic Hormone; Animals; Benzopyrans; Body Temperature; Cyclic AMP; Hippocampus; Humans; Male; Phosphatidylinositols; Raphe Nuclei; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Receptor Agonists; Thiazoles	1998
Full agonistic properties of BAY x 3702 on presynaptic and postsynaptic 5-HT1A receptors electrophysiological studies in the rat hippocampus and dorsal raphe. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 286, Issue:3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoreceptors; Benzopyrans; Hippocampus; Male; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Receptor Agonists; Thiazoles	1998
The 5-HT1A receptor agonist BAY x 3702 prevents staurosporine-induced apoptosis. European journal of pharmacology, 1998, Aug-14, Volume: 355, Issue:1 Topics: Animals; Apoptosis; Benzopyrans; Cells, Cultured; Cerebral Cortex; DNA Fragmentation; Female; Hippocampus; Neurons; Neuroprotective Agents; Piperazines; Pyridines; Rats; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Staurosporine; Thiazoles	1998
Discriminative stimulus properties of the 5-HT1A receptor agonist BAY x 3702 in the rat. European journal of pharmacology, 1998, Sep-11, Volume: 357, Issue:1 Topics: Administration, Oral; Animals; Benzopyrans; Discrimination Learning; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Injections, Intravenous; Male; Piperazines; Pyridines; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Regression Analysis; Serotonin Antagonists; Serotonin Receptor Agonists; Thiazoles; Time Factors	1998
Neuroprotective effect of 5-HT1A receptor agonist, Bay X 3702, demonstrated in vitro and in vivo. European journal of pharmacology, 1998, Oct-23, Volume: 359, Issue:2-3 Topics: Animals; Benzopyrans; Brain; Brain Ischemia; Cell Death; Cell Survival; Cells, Cultured; Cerebral Infarction; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamic Acid; Hippocampus; Male; Neurons; Rats; Rats, Inbred F344; Rats, Long-Evans; Serotonin Receptor Agonists; Thiazoles	1998
A microdialysis study of the in vivo release of 5-HT in the median raphe nucleus of the rat. British journal of pharmacology, 1998, Volume: 125, Issue:6 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic Uptake Inhibitors; Animals; Benzopyrans; Male; Microdialysis; Piperazines; Pyridines; Quinolines; Raphe Nuclei; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Reserpine; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Tetrodotoxin; Thiazoles	1998
The 5-HT1A receptor agonist Bay x 3702 inhibits apoptosis induced by serum deprivation in cultured neurons. European journal of pharmacology, 1999, Apr-09, Volume: 370, Issue:2 Topics: Animals; Apoptosis; Benzopyrans; Cell Survival; Cells, Cultured; Chick Embryo; Chlorpromazine; Culture Media, Serum-Free; Dopamine Antagonists; Dose-Response Relationship, Drug; Hippocampus; Immunoenzyme Techniques; Male; Nerve Growth Factors; Neurons; Neuroprotective Agents; Rats; Rats, Inbred F344; Rats, Long-Evans; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Thiazoles	1999
Enhancement of cortical and hippocampal cholinergic neurotransmission through 5-HT1A receptor-mediated pathways by BAY x 3702 in freely moving rats. Neuroscience letters, 1999, Apr-09, Volume: 265, Issue:1 Topics: Acetylcholine; Analysis of Variance; Animals; Benzopyrans; Cerebral Cortex; Hippocampus; Male; Movement; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin Receptor Agonists; Synaptic Transmission; Thiazoles	1999
Postsynaptic 5-HT1A receptors control 5-HT release in the rat medial prefrontal cortex. Neuroreport, 1999, May-14, Volume: 10, Issue:7 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Benzopyrans; Male; Neurons; Piperazines; Prefrontal Cortex; Pyridines; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Synapses; Thiazoles	1999
The neuroprotective effect of a new serotonin receptor agonist, BAY X3702, upon focal ischemic brain damage caused by acute subdural hematoma in the rat. Brain research, 1999, Oct-23, Volume: 845, Issue:2 Topics: Animals; Benzopyrans; Brain Ischemia; Dose-Response Relationship, Drug; Hematoma, Subdural, Acute; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Thiazoles	1999
BAY X 3702. Drugs in R&D, 1999, Volume: 1, Issue:1 Topics: Animals; Benzopyrans; Drugs, Investigational; Humans; Male; Neuroprotective Agents; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Stroke; Thiazoles	1999
S-100beta protects cultured neurons against glutamate- and staurosporine-induced damage and is involved in the antiapoptotic action of the 5 HT(1A)-receptor agonist, Bay x 3702. Brain research, 2000, Mar-06, Volume: 858, Issue:1 Topics: Animals; Animals, Newborn; Antibodies; Apoptosis; Astrocytes; Benzopyrans; Cell Survival; Cells, Cultured; Chick Embryo; Coculture Techniques; Corpus Striatum; Cytoprotection; Dose-Response Relationship, Drug; Glutamic Acid; Hippocampus; Male; Nerve Growth Factors; Neurons; Neuroprotective Agents; Piperazines; Pyridines; Rats; Rats, Inbred F344; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Serotonin Antagonists; Staurosporine; Thiazoles	2000
In vivo actions of the selective 5-HT1A receptor agonist BAY x 3702 on serotonergic cell firing and release. Naunyn-Schmiedeberg's archives of pharmacology, 2000, Volume: 362, Issue:3 Topics: Analysis of Variance; Animals; Benzopyrans; Brain; Male; Microdialysis; Piperazines; Pyridines; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Thiazoles	2000
Stimulation of 5-HT(1A) receptors reduces apoptosis after transient forebrain ischemia in the rat. Brain research, 2000, Nov-10, Volume: 883, Issue:1 Topics: Animals; Apoptosis; Benzopyrans; DNA Fragmentation; Electrophoresis, Agar Gel; In Situ Nick-End Labeling; Ischemic Attack, Transient; Male; Neuroprotective Agents; Piperazines; Pyridines; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Thiazoles	2000
Inhibition of evoked glutamate release by the neuroprotective 5-HT(1A) receptor agonist BAY x 3702 in vitro and in vivo. Brain research, 2001, Jan-05, Volume: 888, Issue:1 Topics: Animals; Aspartic Acid; Benzopyrans; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Space; Glutamic Acid; Hippocampus; Infarction, Middle Cerebral Artery; Male; Microdialysis; Neuroprotective Agents; Organ Culture Techniques; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Synaptic Transmission; Thiazoles	2001
The selective 5-HT(1A) receptor agonist repinotan HCl attenuates histopathology and spatial learning deficits following traumatic brain injury in rats. Neuroscience, 2001, Volume: 106, Issue:3 Topics: Animals; Benzopyrans; Body Temperature; Brain; Brain Injuries; Cognition; Cognition Disorders; Dizocilpine Maleate; Drug Administration Schedule; Excitatory Amino Acid Antagonists; Hippocampus; Male; Maze Learning; Nerve Degeneration; Neurons; Neuroprotective Agents; Postural Balance; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Thiazoles; Vestibular Nuclei	2001
Effect of 5-hydroxytryptamine 1A receptor agonist BAY X 3702 on BCL-2 and BAX proteins level in the ipsilateral cerebral cortex of rats after transient focal ischaemia. Neuroscience, 2001, Volume: 107, Issue:3 Topics: Animals; Benzopyrans; Cerebral Cortex; Ischemic Attack, Transient; Male; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Long-Evans; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Thiazoles	2001
Oral post-lesion administration of 5-HT(1A) receptor agonist repinotan hydrochloride (BAY x 3702) attenuates NMDA-induced delayed neuronal death in rat magnocellular nucleus basalis. Neuroscience, 2001, Volume: 108, Issue:4 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylcholine; Administration, Oral; Animals; Apoptosis; Basal Nucleus of Meynert; Behavior, Animal; Benzopyrans; Choline O-Acetyltransferase; Excitatory Amino Acid Agonists; Male; Memory; N-Methylaspartate; Neurons; Neuroprotective Agents; Parietal Lobe; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Thiazoles	2001
The G protein-coupled 5-HT1A receptor causes suppression of caspase-3 through MAPK and protein kinase Calpha. Biochimica et biophysica acta, 2003, Apr-07, Volume: 1640, Issue:1 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Apoptosis; Benzopyrans; Calcium; Caspase 3; Caspase Inhibitors; Cell Line; Enzyme Activation; Hydrogen Peroxide; Mice; Mitogen-Activated Protein Kinases; Neuroprotective Agents; Protein Kinase C; Protein Kinase C-alpha; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Thiazoles	2003
In vivo modulation of 5-hydroxytryptamine release in mouse prefrontal cortex by local 5-HT(2A) receptors: effect of antipsychotic drugs. The European journal of neuroscience, 2003, Volume: 18, Issue:5 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminopyridines; Anesthetics, Local; Animals; Antipsychotic Agents; Benzopyrans; Blotting, Western; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Fluorobenzenes; Immunohistochemistry; In Situ Hybridization; Indoles; Indophenol; Male; Mice; Mice, Inbred C57BL; Microdialysis; Piperidines; Prazosin; Prefrontal Cortex; Quinoxalines; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; RNA, Messenger; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Tetrodotoxin; Thiazoles; Time Factors	2003
Neuroprotective efficacy of repinotan HCl, a 5-HT1A receptor agonist, in animal models of stroke and traumatic brain injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2005, Volume: 25, Issue:4 Topics: Animals; Benzopyrans; Biomarkers; Brain; Brain Injuries; Hematoma, Subdural, Acute; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; Rats; Rats, Long-Evans; Receptor, Serotonin, 5-HT1A; Serotonin Receptor Agonists; Stroke; Succinate Dehydrogenase; Thiazoles	2005
Pupil reaction: a valid sensitive clinical biomarker for 5-HT compounds. Basic & clinical pharmacology & toxicology, 2005, Volume: 96, Issue:3 Topics: Adolescent; Adult; Benzopyrans; Biomarkers; Humans; Male; Middle Aged; Pupil; Serotonin 5-HT1 Receptor Agonists; Thiazoles	2005
Pharmacokinetics of repinotan in healthy and brain injured animals. Biopharmaceutics & drug disposition, 2005, Volume: 26, Issue:6 Topics: Animals; Benzopyrans; Blood-Brain Barrier; Brain; Brain Injuries; Male; Rats; Rats, Wistar; Serotonin Receptor Agonists; Thiazoles	2005
Activation of pyramidal cells in rat medial prefrontal cortex projecting to ventral tegmental area by a 5-HT1A receptor agonist. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2006, Volume: 16, Issue:4 Topics: Action Potentials; Analysis of Variance; Animals; Benzopyrans; Dopamine; Dose-Response Relationship, Drug; Electric Stimulation; Evoked Potentials; Male; Models, Neurological; Piperazines; Prefrontal Cortex; Pyramidal Cells; Pyridines; Rats; Rats, Wistar; Serotonin Antagonists; Serotonin Receptor Agonists; Thiazoles; Time Factors; Ventral Tegmental Area	2006
Involvement of 5-HT1A receptors in prefrontal cortex in the modulation of dopaminergic activity: role in atypical antipsychotic action. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Nov-23, Volume: 25, Issue:47 Topics: Animals; Antipsychotic Agents; Benzopyrans; Dopamine; Electrophysiology; Extracellular Fluid; Haloperidol; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neural Pathways; Neurons; Osmolar Concentration; Piperazines; Prefrontal Cortex; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Serotonin 5-HT1 Receptor Agonists; Serotonin Receptor Agonists; Thiazoles; Ventral Tegmental Area	2005
5-HT1A receptor agonist-mediated protection from MPTP toxicity in mouse and macaque models of Parkinson's disease. Neurobiology of disease, 2006, Volume: 23, Issue:1 Topics: Animals; Benzopyrans; Brain; In Situ Hybridization; Macaca; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neurons; Neuroprotective Agents; Parkinsonian Disorders; Receptor, Serotonin, 5-HT1A; Serotonin Receptor Agonists; Thiazoles; Tyrosine 3-Monooxygenase	2006
Repinotan, a selective 5-HT1A-R-agonist, antagonizes morphine-induced ventilatory depression in anesthetized rats. Anesthesia and analgesia, 2010, Volume: 111, Issue:4 Topics: Animals; Benzopyrans; Dose-Response Relationship, Drug; Male; Morphine; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Respiratory Insufficiency; Serotonin 5-HT1 Receptor Agonists; Serotonin Receptor Agonists; Thiazoles	2010
Selective 5-HT(1A)-R-agonist repinotan prevents remifentanil-induced ventilatory depression and prolongs antinociception. Anesthesiology, 2012, Volume: 116, Issue:1 Topics: Analgesics, Opioid; Anesthetics, Intravenous; Animals; Benzopyrans; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Hemodynamics; Hypnotics and Sedatives; Male; Pain Measurement; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Remifentanil; Respiratory Insufficiency; Respiratory Mechanics; Serotonin Receptor Agonists; Thiazoles	2012