thiazoles has been researched along with pyrimidinones in 205 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 40 (19.51) | 18.7374 |
| 1990's | 82 (40.00) | 18.2507 |
| 2000's | 30 (14.63) | 29.6817 |
| 2010's | 41 (20.00) | 24.3611 |
| 2020's | 12 (5.85) | 2.80 |
| Authors | Studies |
|---|---|
| Kobayashi, G; Matsuda, Y; Okuda, H; Tominaga, Y | 1 |
| Bergstrand, H; Lundquist, B | 1 |
| Bergstrand, H; Eriksson, T; Hallberg, A; Johansson, B; Karabelas, K; Michelsen, P; Nybom, A | 1 |
| Aussel, C; Breittmayer, JP; Pelassy, C | 1 |
| Lundberg, GA; Sommarin, M | 1 |
| Harrison, RA; Roldan, ER | 2 |
| Obel, N | 1 |
| Cobbold, PH; Sanchez-Bueno, A | 1 |
| Aboulwafa, OM; Ismail, KA; Koreish, EA | 1 |
| Pek, SB; Thomas, TP | 1 |
| Desai, NN; Mattie, ME; Olivera, A; Spiegel, S; Zhang, H | 1 |
| Fukami, K; Takenawa, T | 1 |
| Light, PE; Murphy, RL; Publicover, SJ; Smith, ME | 1 |
| De Pont, JJ; Ederveen, AG; van Emst-de Vries, SE; Willems, PH | 2 |
| Foreman, JC; Hayes, NA; McLeod, J | 1 |
| de Médicis, R; Gilbert, C; Grimard, M; Lussier, A; Naccache, PH; Poubelle, PE; Roberge, CJ | 1 |
| Momose, K; Nobe, K; Ohata, H | 3 |
| Boarder, MR; Jones, JA; Owen, PJ | 2 |
| Karibe, H; Oishi, K; Uchida, MK | 1 |
| de Nucci, G; Mitchell, JA; Vane, JR; Warner, TD | 1 |
| Amiel, C; Cherqui, G; Escoubet, B; Garestier, MC | 1 |
| Baldari, CT; Donati, D; Macchia, G; Massone, A; Parente, L; Telford, JL | 1 |
| el-Fakahany, EE; Lai, WS | 1 |
| Hirst, JJ; Jenkin, G; Rice, GE; Thorburn, GD | 1 |
| Higgins, T; Morris, C; Nånberg, E; Rozengurt, E; Vara, F | 1 |
| Dickinson, KE; Hirschowitz, BI; Hokin, LE; Pruitt, RE; Sekar, MC | 1 |
| Chow, SC; Jondal, M | 1 |
| Hiura, M; Ishibashi, S; Ohtsuka, T; Okamura, N; Yoshida, K | 1 |
| de Chaffoy de Courcelles, D | 1 |
| Francis, LP; Singh, J | 1 |
| Cronin, MJ; Johnson, RM; King, KL; Napier, MA | 1 |
| Dunn, WD; Nadler, J; Natarajan, R; Stern, N | 1 |
| Goodrum, DD; Sachs, G; Wheeler, LA | 1 |
| David, JD; Faser, CR; Perrot, GP | 1 |
| Goldstein, L; Musch, MW | 1 |
| Cantwell, ME; Foreman, JC | 1 |
| Butler, RD; Evans, RL; McCrohan, CR | 1 |
| Holzer, P; Lippe, IT | 1 |
| Caon, AC; Gilbert, C; Liao, N; McColl, SR; Naccache, PH; Therrien, S | 1 |
| Dufy, B; Mollard, P; Schlegel, W; Vacher, P; Winiger, BP | 1 |
| Grinstein, S; Nasmith, P | 1 |
| Kanoh, H; Sakane, F; Yamada, K | 1 |
| Burch, RM | 1 |
| Chiang, CF; Hauser, G | 1 |
| Fu, T; Hagiwara, M; Hidaka, H; Nozawa, Y; Okano, Y | 1 |
| Huang, TF; Hung, ML; Ouyang, C; Teng, CM | 1 |
| Hattori, H; Nakashima, S; Nozawa, Y; Suganuma, A; Tohmatsu, T | 1 |
| Nunn, DL; Watson, SP | 1 |
| Dale, MM; Penfield, A | 1 |
| Becker, EL; Gomez-Cambronero, J; Molski, TF; Sha'afi, RI | 1 |
| Al-Mohanna, FA; Cooke, E; Hallett, MB | 1 |
| Gavioli, R; Giuliani, A; Spisani, S; Traniello, S | 1 |
| Joseph, S; Kakkar, VV; Krishnamurthi, S | 1 |
| de Nucci, G; Gryglewski, RJ; Vane, JR; Warner, TD | 1 |
| Mahadevappa, VG | 1 |
| Dale, MM; Muid, RE; Twomey, B | 1 |
| Mahadevappa, VG; Sicilia, FJ | 1 |
| Becker, EL; Gomez-Cambronero, J; Huang, CK; Mege, JL; Molski, TF; Sha'afi, RI; Tao, W | 1 |
| Campbell, GP; Hesketh, JE; McKenzie, N | 1 |
| Knigge, U; Matzen, S; Warberg, J | 1 |
| Arcari, G; Castello, R; Ceserani, R; Doria, G; Magrini, R; Passarotti, C; Sala, R; Sberze, P; Tibolla, M; Toti, D | 1 |
| de Chaffoy de Courcelles, DC; Roevens, P; Van Belle, H | 1 |
| Dale, MM; Muid, RE; Penfield, A | 1 |
| Leitz, T; Müller, WA | 1 |
| Halenda, SP; Rehm, AG | 1 |
| Barritt, GJ; Chataway, TK | 1 |
| Morris, C; Rice, P; Rozengurt, E | 1 |
| Anderson, RJ; Breckon, R; Burke, C; Dixon, BS | 1 |
| Deli, E; Kiss, Z; Koeffler, HP; Kuo, JF; Pettit, GR; Shoji, M; Vogler, WR | 1 |
| Coburn, RA; Glennon, RA | 1 |
| Berg-Nielsen, K; Bernatek, E; Stensrud, T | 1 |
| Goldman, IM | 1 |
| Gaines, JJ; Glennon, RA; Rogers, ME | 1 |
| Błaszczyk, B; Fiszer-Maliszewska, L; Giełdanowski, J; Kowalczyk-Bronisz, SH; Machoń, Z; Mordarski, M; Raberger, G; Wieczorek, J; Wieczorek, Z; Zimecki, M | 1 |
| Alkon, DL; Inoue, H; Kouchi, T; Sakakibara, M; Yoshioka, T | 1 |
| O'Keefe, KL; Warner, JA | 1 |
| Barnes, PJ; Giembycz, MA; Lindsay, MA; Perkins, RS | 1 |
| Gavioli, R; Lanza, F; Moretti, S; Reali, E; Spisani, S; Traniello, S | 1 |
| Amer, FA; el-Ablak, FZ; Etman, HA; Metwally, MA | 1 |
| el Bawab, S; Lagarde, M; Macovschi, O; Prigent, AF | 1 |
| Hurttia, H; Leino, L; Peltonen, E | 1 |
| Inagami, T; Inui, H; Kitami, Y; Kondo, T; Konishi, F | 1 |
| Au, BT; Hellewell, PG; Rossi, AG; Teixeira, MM; Williams, TJ | 1 |
| Fujihara, A; Kamato, T; Miyata, K; Nishida, A; Takeda, M; Yuki, H | 1 |
| Bertagnolo, V; Borgatti, P; Capitani, S; Mazzoni, M; Osti, F; Previati, M | 1 |
| Brockman, JA; Hayes, SH; Lee, JS; Lowberger, LL; Silvia, WJ; Trammell, DS | 1 |
| Acamovic, F; Mackie, SC; Morrison, KS; Palmer, RM; Thompson, MG | 1 |
| Boonen, GJ; de Koster, BM; Elferink, JG | 1 |
| Goin, M; Jimenez de Asua, L; Pignataro, O | 1 |
| Chen, Q; Jeng, I; Klemm, N | 1 |
| Livne, AA; Packham, MA; Rand, ML; Ruben, DH | 1 |
| Gay, JC | 1 |
| Boonen, GJ; de Koster, BM; Elferink, JG; VanSteveninck, J | 1 |
| Kester, M | 1 |
| Jacobs, M; Pires, JG; Ramage, AG | 1 |
| Beckman, BS; Clejan, S; Dotson, R; Mallia, C; Vinson, D | 1 |
| Frith, T; Sadler, SE; Wasserman, WJ | 1 |
| Casaseca, T; Flores, I; Kanoh, H; Martinez-A, C; Merida, I | 1 |
| Imoto, K; Kaneko, M; Ohshika, H; Sakano, S; Takemura, H; Yamada, K | 1 |
| McKay, C; Miller, A | 1 |
| Beckman, B; Clejan, S; Corb, M; Ide, C; Walker, C; Wolf, E | 1 |
| Burt, RP; Chapple, CR; Marshall, I | 1 |
| Hurttia, H; Leino, L | 1 |
| Alpert, NM; Babich, JW; Bonab, AA; Elmaleh, DR; Fischman, AJ; Rauch, SL; Rubin, RH; Shoup, TM; Williams, SA | 1 |
| Packham, MA; Rand, ML; Ruben, DH | 1 |
| Ginsberg, J; Matowe, WC | 1 |
| Ishii, A; Konishi, Y; Kotani, T; Nagaki, Y; Okamoto, K; Okukado, N; Suehiro, S; Yago, H | 1 |
| Pagano, RE; Salman, M | 1 |
| Brown, ER; Dempsey, BK; Lew, DB; Malik, KU; Wright, HM | 1 |
| Atsumi, T; Hosoi, K; Kurihara, K; Shioda, Y; Sugita, K; Ueha, T | 1 |
| Jimenez de Asua, L; Levy, CS; Rudland, PS; Sauane, M | 1 |
| Boyan, BD; Dean, DD; Schwartz, Z; Sylvia, VL | 1 |
| Danel, K; Nielsen, C; Pedersen, EB | 1 |
| Algueró, M; Bartroli, J; Boncompte, E; Conte, L; Forn, J; García-Rafanell, J; Merlos, M; Ramis, J; Turmo, E; Vericat, ML | 1 |
| De Clercq, E; Drach, JC; Huffman, JH; Lewis, AF; Mustain, SD; Ojwang, JO; Rando, RF; Revankar, GR; Sommadossi, JP | 1 |
| El Bawab, S; Lagarde, M; Némoz, G; Prigent, AF; Zakaroff-Girard, A | 1 |
| Chaya, S; Hamada, Y; Hotta, N; Ienaga, K; Kamiya, H; Kasuya, Y; Kato, K; Koh, N; Miwa, K; Mizubayashi, R; Nakamura, J; Nakashima, E; Nakayama, M; Naruse, K; Sakakibara, F; Yasuda, Y | 1 |
| Ascher-Landsberg, J; Phillippe, M; Saunders, T | 1 |
| Chakrabarti, R; Kumar, S | 1 |
| Caruso, A; Cutuli, V; Mangano, N; Modica, M; Santagati, A; Santagati, M | 1 |
| Alfranca, A; Aragonés, J; Jones, DR; Landázuri, MO; Martin, S; Mérida, I; San Juan, MA; Vara, A; Vidal, F | 1 |
| Groot, JA; Meijer, HP; Munnik, T; Oprins, JC; van der Burg, C | 1 |
| Millan, MJ; Newman-Tancredi, A; Touzard, M; Verrièle, L | 1 |
| Balraju, V; Chakrabarti, R; Kumar, SK; Lohray, BB; Lohray, VB; Madhavan, GR; Mamidi, RN; Misra, P; Rajagopalan, R; Rajesh, BM; Vikramadithyan, RK | 1 |
| Eppinger, E; Meinhardt, G; Schmidmaier, R | 1 |
| Chakrabarti, R; Hiriyan, J; Kumar, MP; Kumar, SK; Mamidi, NV; Misra, P; Rajagopalan, R; Rao, CS; Suresh, J; Vikramadithyan, RK | 1 |
| Cantrel, C; Gawer, M; Kader, JC; Ruelland, E; Zachowski, A | 1 |
| Chen, WY; Fang, X; Mao, LZ; Roldan, ER; Shi, QX; Yu, SQ; Yuan, YY | 1 |
| Anderson, JM; McNally, AK | 1 |
| Rózanowska, M; Sarna, T; Wrona, M | 1 |
| Kapur, S; Mamo, D; Mann, S; Papatheodorou, G; Remington, G; Shammi, CM; Therrien, F | 1 |
| Akberali, PM; Holla, BS; Rao, BS; Sarojini, BK | 1 |
| Badwey, JA; Batista, EL; Van Dyke, TE; Warbington, M | 1 |
| Chen, C; Pontillo, J | 1 |
| Frondoza, CG; Hungerford, DS; Lindmark, L; Phan, PV; Polotsky, A; Sohrabi, A | 1 |
| Ehmer, PB; Gilissen, RA; Kantharaj, E; Mackie, C; Tuytelaars, A; Van Vlaslaer, A | 1 |
| Arana-Ceballos, FA; Brearley, CA; Dörmann, P; Gómez-Merino, FC; Mueller-Roeber, B; Skirycz, A; Trejo-Téllez, LI | 1 |
| Caci, E; Du, K; Galietta, LJ; Lukacs, GL; Pedemonte, N; Verkman, AS; Zegarra-Moran, O | 1 |
| Batlle, A; Casas, A; Di Venosa, G; Hasan, T; Ortel, B; Perotti, C; Saccoliti, M | 1 |
| Ashok, M; Holla, BS; Kumari, NS | 1 |
| Abdelly, C; Bordenave, M; Ghars, MA; Lefebvre, D; Leprince, AS; Mazars, C; Parre, E; Richard, L; Savouré, A; Thiery, L | 1 |
| Have, AT; Lamattina, L; Laxalt, AM; Raho, N | 1 |
| Kohgo, Y; Motomura, W; Nagamine, M; Okumura, T; Takahashi, N; Tanno, S | 1 |
| Apostolakos, P; Galanopoulou, D; Galatis, B; Komis, G; Quader, H | 1 |
| Li, CR; Wang, GB; Zu, Y | 1 |
| de Boschero, MG; Giusto, NM; Zulian, SE | 1 |
| Estrada-Gutierrez, G; Gomez-Lopez, N; Jimenez-Zamudio, L; Vadillo-Ortega, F; Vega-Sanchez, R | 1 |
| Bodade, RG; Dawane, BS; Khandare, NT; Khobragade, CN; Konda, SG | 1 |
| Busuttil, RW; Farmer, DG; Gao, F; Ji, H; Ke, B; Kupiec-Weglinski, JW; Qiao, B; Shen, XD; Zhai, Y | 1 |
| Perumal, V; Raja, A; Raman, B; Syed Ahamed Kabeer, B; Thomas, A | 1 |
| Kito, Y; Suzuki, H | 1 |
| Kallinen, SA; Kontturi, LS; Salonen, V; Uusi-Oukari, M | 1 |
| Cao, T; Cheng, Q; Li, J; Xu, C; Zhang, L; Zhang, M | 1 |
| Bartkowiak, G; Schroeder, G; Wyrzykiewicz, E | 1 |
| Agrawal, S; Bett, AJ; Casimiro, DR; Dubey, SA; Jiang, W; Kandimalla, ER; Nowak, I; Precopio, M; Putta, MR; Struthers, M; Sun, Z; Tang, JX; Wang, H; Wisniewski, T; Yu, D | 1 |
| Akifusa, S; Kamio, N; Yamashita, Y | 1 |
| Kawada-Matsuo, M; Li, D; Saito, N; Shibata, Y; Shirai, Y; Yamashita, Y | 1 |
| Hanazato, M; Inoue, H; Konuma, T; Takita, T | 1 |
| Harper, L; Holden, NJ; Savage, CO; Wakelam, MJ; Williams, JM; Young, SP | 1 |
| Ahn, J; Cechetto, J; Choi, I; Han, SJ; Jo, M; Jo, S; Ju, MK; Kim, J; Kim, TH; Kim, Y; Ko, Y; Lee, D; Liuzzi, M; Nam, J; No, Z; Ok, T; Park, C; Park, Y; Seo, M; So, W; Sommer, P; Yoon, J | 1 |
| Bajpai, M; Banerjee, A; Gharat, LA; Gudi, GS; Gullapalli, S; Sangana, RR; Yadav, PS | 1 |
| Aarts, M; Ashworth, A; Garcia-Murillas, I; Gevensleben, H; Hurd, MS; Sharpe, R; Shumway, SD; Toniatti, C; Turner, NC | 1 |
| Bisselink, YJ; de Vries, EG; Heijink, AM; Krajewska, M; Seinstra, RI; Silljé, HH; van Vugt, MA | 1 |
| Chuang, CC; Kennedy, A; Kincaid, J; Marsh, A; Martinez, K; McIntosh, M; Reid, T; Shyamasundar, S | 1 |
| Goldschmidt, H; Petro, E; Raben, DM; Tu-Sekine, B | 1 |
| Abounader, R; Dominguez, CL; Floyd, DH; Harris, TE; Kefas, BA; Lee, JK; Mullins, GR; Purow, BW; Wilson, GM; Xiao, A; Xin, W; Yacur, MN | 1 |
| Giusto, NM; Ilincheta de Boschero, MG; Natalini, PM; Zulian, SE | 1 |
| Kunii, N; Liu, K; Mizuno, H; Saga, H; Sakai, H; Sakane, F; Sasaki, S; Sato, M | 1 |
| Edwards, NL; So, A | 1 |
| Antonakos, B; Cooke, VG; Danial, NN; Flemming, D; Hurov, KE; Jones, MD; Korn, JM; Ledell, J; Lehár, J; Mishina, Y; Schoumacher, M; Sellers, WR; Shao, W; Sonkin, D; Steiger, J; Stump, MD; Yan-Neale, Y | 1 |
| Enders, D; Ni, Q; Raabe, G; Song, X; Xiong, J | 1 |
| Beausoleil, SA; Benes, CH; Costa, C; Ebi, H; Engelman, JA; Faber, AC; Hall, B; Hirsch, E; Huang, A; Jakubik, CT; Martini, M; Nishtala, M; Rikova, K; Wang, Y; Zhao, J | 1 |
| Cescon, DW; Gorrini, C; Mak, TW | 1 |
| Cisneros, MI; Cubitt, B; de la Torre, JC; Henthorn, KS; Iwasaki, M; Lama, J; Ngo, N | 1 |
| Carlsson, J; Hill, SJ; Ranganathan, A; Stoddart, LA | 1 |
| Baldanzi, G; Baldari, CT; Biskup, C; Das, R; Graziani, A; Kapnick, SM; Larsen, SE; Malacarne, V; Nichols, KE; Patrussi, L; Rubio, I; Ruffo, E; Schwartzberg, PL; Snow, AL; Tedrick, P; Verbist, K; Wülfing, C | 1 |
| Liu, P; Xu, B; Zhang, C | 1 |
| Boroda, S; Harris, TE; Niccum, M; Purow, BW; Raje, V | 1 |
| Bhutkar, A; Chen, PY; Chung, KM; Dorans, KJ; Hong, E; Jacks, T; Muzumdar, MD; Noll, EM; Sprick, MR; Trumpp, A | 1 |
| Backman, JT; Filppula, AM; Mustonen, TM | 1 |
| Kosmalski, T; Kołodziejska, R; Kupczyk, D; Modzelewska-Banachiewicz, B; Płazińska, A; Studzińska, R | 1 |
| Abd Elhameed, AA; Bayomi, SM; El-Bendary, ER; El-Gohary, NS; Shaaban, MI | 1 |
| Gajda, M; Jasek-Gajda, E; Jasińska, M; Lis, GJ; Litwin, JA | 1 |
| Baldanzi, G; Bertoni, A; Capello, D; Fresu, LG; Gesu, A; Graziani, A; Massarotti, A; Ruffo, E; Snow, AL; Talmon, M; Tron, GC; Varma, KSS; Velnati, S | 1 |
| Côté, M; Dorion, SS; Fullerton, MD; Kobasa, D; LeBlond, ND; Ottenbrite, MAF; Qiu, S; Smith, TKT; Stewart, CM | 1 |
| Bocchicchio, S; Irusta, G; Tesone, M | 1 |
| Ali, E; Jin, R; Li, J; Liao, X; Mao, K; Ren, Z; Wan, H; Zhang, X | 1 |
| Barraja, P; Carbone, A; Galietta, LJV; Montalbano, A; Scudieri, P; Spanò, V | 1 |
| Halsne, R; Kavaliauskiene, S; Klokk, TI; Klose, C; Lingelem, ABD; Sandvig, K; Skotland, T; Surma, MA | 1 |
| Ametamey, SM; Auberson, YP; Briard, E; He, Y; Mu, L; Numao, S; Schibli, R; Whitehead, DM | 1 |
| Azad, AK; Eitzen, G; Moore, RB; Murray, AG; Oudit, GY; Vanhaesebroeck, B; Zhabyeyev, P | 1 |
| Araklitis, G; Baines, G; Cardozo, L; da Silva, AS; Robinson, D | 1 |
| Rechberger, T; Wróbel, A | 1 |
| Campeau, L; Fogaing, C; Mossa, AH | 1 |
| Mukai, S; Nomi, M; Sengoku, A; Yamada, S; Yanagiuchi, A | 1 |
| Anko, M; Hasegawa, S; Matsumoto, KI; Ohara, M; Suzuki, M | 1 |
| Deshpande, DA; Javed, E; Kambayashi, T; Lim, JM; Nayak, AP; Pan, S; Panettieri, RA; Penn, RB; Shah, SD; Sharma, P; Yadav, SK | 1 |
| Girman, CJ; Kennelly, MJ; Mudd, PN; Rhodes, T; Shortino, D; Thomas, E | 1 |
| Dmochowski, R; Gleicher, S; Reynolds, WS; Sebesta, EM | 1 |
| Fukuhara, H; Kinjo, M; Masuda, K; Miyakawa, J; Nakamura, Y; Tambo, M | 1 |
7 review(s) available for thiazoles and pyrimidinones
| Article | Year |
|---|---|
The use of diacylglycerol kinase inhibitors for elucidating the roles of protein kinase C.
Topics: Animals; Blood Platelets; Diacylglycerol Kinase; Diglycerides; Enzyme Activation; Humans; Neutrophils; Phosphotransferases; Piperidines; Protein Kinase C; Pyrimidinones; Quinazolines; Quinazolinones; Rabbits; Receptors, Cell Surface; Second Messenger Systems; Thiazoles | 1990 |
Emerging therapies for gout.
Topics: Acetamides; Adrenocorticotropic Hormone; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Benzodiazepines; Febuxostat; Gout; Gout Suppressants; Humans; Imino Furanoses; Interleukin 1 Receptor Antagonist Protein; Interleukin-1beta; Melanocortins; Phenylacetates; Polyethylene Glycols; Pyrimidinones; Recombinant Fusion Proteins; Thiazoles; Thioglycolates; Triazoles; Urate Oxidase; Uricosuric Agents | 2014 |
An overview on chemical structures as ΔF508-CFTR correctors.
Topics: Animals; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Humans; Mutation; Protein Folding; Pyrimidinones; Thiazoles | 2019 |
Recent advances in managing overactive bladder.
Topics: Acetanilides; Adrenergic beta-3 Receptor Agonists; Botulinum Toxins; Denervation; Drug Implants; Humans; Laser Therapy; Pyrimidinones; Pyrrolidines; Tamoxifen; Thiazoles; Treatment Outcome; Urinary Bladder, Overactive | 2020 |
Evaluating vibegron for the treatment of overactive bladder.
Topics: Acetanilides; Adrenergic beta-3 Receptor Agonists; Humans; Muscarinic Antagonists; Pyrimidinones; Pyrrolidines; Thiazoles; Treatment Outcome; Urinary Bladder, Overactive | 2021 |
Are Beta 3 Adrenergic Agonists Now the Preferred Pharmacologic Management of Overactive Bladder?
Topics: Acetanilides; Adrenergic alpha-1 Receptor Antagonists; Adrenergic beta-3 Receptor Agonists; Cholinergic Antagonists; Cost-Benefit Analysis; Humans; Muscarinic Antagonists; Phosphodiesterase Inhibitors; Pyrimidinones; Pyrrolidines; Thiazoles; Treatment Outcome; Urinary Bladder, Overactive; Urological Agents | 2020 |
Efficacy of Vibegron and Mirabegron for Overactive Bladder: A Systematic Literature Review and Indirect Treatment Comparison.
Topics: Acetanilides; Adrenergic beta-3 Receptor Agonists; Clinical Trials, Phase III as Topic; Double-Blind Method; Humans; Muscarinic Antagonists; Pyrimidinones; Pyrrolidines; Randomized Controlled Trials as Topic; Thiazoles; Treatment Outcome; Urinary Bladder, Overactive | 2021 |
2 trial(s) available for thiazoles and pyrimidinones
| Article | Year |
|---|---|
A PET study of dopamine D2 and serotonin 5-HT2 receptor occupancy in patients with schizophrenia treated with therapeutic doses of ziprasidone.
Topics: Adult; Antipsychotic Agents; Brain; Corpus Striatum; Drug Administration Schedule; Female; Humans; Male; Piperazines; Psychotic Disorders; Pyrimidinones; Raclopride; Receptors, Dopamine D2; Receptors, Serotonin, 5-HT2; Schizophrenia; Thiazoles; Tomography, Emission-Computed | 2004 |
Comparison of Mirabegron and Vibegron in Women With Treatment-Naive Overactive Bladder: A Randomized Controlled Study.
Topics: Acetanilides; Aged; Aged, 80 and over; Female; Humans; Middle Aged; Prospective Studies; Pyrimidinones; Pyrrolidines; Quality of Life; Thiazoles; Treatment Outcome; Urinary Bladder, Overactive; Urological Agents | 2023 |
196 other study(ies) available for thiazoles and pyrimidinones
| Article | Year |
|---|---|
[Enamino carbodithioates. III. Methyl 6-aminouracil-5-carbodithioates. (3). Synthesis and reactions of 3-methylthioisothiazolo[3,4-d]pyrimidine-4,6(5H,7H)-diones (author's transl)].
Topics: Amides; Amines; Chemical Phenomena; Chemistry; Pyrimidinones; Thiazoles; Uracil | 1979 |
Human basophil histamine release is differently affected by inhibitors of calmodulin, diacylglycerol kinase and peptidyl prolyl cis-trans isomerase in a secretagogue specific manner.
Topics: Amino Acid Isomerases; Basophils; Benzimidazoles; Calmodulin; Carrier Proteins; Diacylglycerol Kinase; Felodipine; Histamine Release; Humans; Imidazoles; Isoquinolines; Peptidylprolyl Isomerase; Phenothiazines; Phosphotransferases; Pyrimidinones; Tacrolimus; Thiazoles | 1992 |
Modulation of neutrophil superoxide generation by inhibitors of protein kinase C, calmodulin, diacylglycerol and myosin light chain kinases, and peptidyl prolyl cis-trans isomerase.
Topics: Amino Acid Isomerases; Basophils; Calmodulin; Carbazoles; Carrier Proteins; Diacylglycerol Kinase; Histamine Release; Humans; Indole Alkaloids; Myosin-Light-Chain Kinase; Neutrophils; Peptidylprolyl Isomerase; Phosphotransferases; Protein Kinase C; Pyrimidinones; Superoxides; Tacrolimus; Tetradecanoylphorbol Acetate; Thiazoles | 1992 |
A diacylglycerol kinase is involved in the regulation of interleukin-2 synthesis in Jurkat T cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Cell Line; Diacylglycerol Kinase; Diglycerides; Enzyme Activation; Humans; Interleukin-2; Isoquinolines; Phosphatidic Acids; Phosphatidylserines; Phosphotransferases; Piperazines; Pyrimidinones; Signal Transduction; Thiazoles | 1992 |
Diacylglycerol kinase in plasma membranes from wheat.
Topics: Cell Membrane; Detergents; Diacylglycerol Kinase; Enzyme Activation; Kinetics; Phosphatidylinositols; Phosphotransferases; Pyrimidinones; Thiazoles; Triticum | 1992 |
The role of diacylglycerol in the exocytosis of the sperm acrosome. Studies using diacylglycerol lipase and diacylglycerol kinase inhibitors and exogenous diacylglycerols.
Topics: Acrosome; Animals; Calcimycin; Calcium; Cyclohexanones; Diacylglycerol Kinase; Diglycerides; Exocytosis; Lipoprotein Lipase; Male; Neomycin; Phosphatidic Acids; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphotransferases; Pyrimidinones; Sheep; Spermatozoa; Thiazoles | 1992 |
Staphylococcus albus-induced protein kinase C translocation in human neutrophils: the effect of opsonization, cytochalasin B, pertussis toxin, intra- and extracellular calcium, and R59022.
Topics: Biological Transport; Calcium; Cytochalasin B; Diacylglycerol Kinase; Diglycerides; Dose-Response Relationship, Drug; Humans; Neutrophils; Pertussis Toxin; Phagocytosis; Phosphotransferases; Protein Kinase C; Pyrimidinones; Signal Transduction; Staphylococcus; Superoxides; Thiazoles; Time Factors; Virulence Factors, Bordetella | 1992 |
Effect of perturbing diacylglycerol metabolism on cytosolic free Ca2+ oscillations induced in single hepatocytes.
Topics: Animals; Calcium; Cells, Cultured; Cytosol; Diacylglycerol Kinase; Diglycerides; Kinetics; Liver; Male; Oscillometry; Phenylephrine; Phosphotransferases; Pyrimidinones; Rats; Rats, Wistar; Thiazoles | 1992 |
Synthesis and antimicrobial activity of some thiazolinyl tetrahydrobenzo[b]thiophenes and thiazolinyl tetrahydrobenzothieno[2,3-d]pyrimidin-4-ones.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antifungal Agents; Candida albicans; Escherichia coli; Microbial Sensitivity Tests; Nystatin; Pyrimidinones; Staphylococcus aureus; Thiazoles; Thiophenes | 1992 |
Diacylglycerol inhibits potassium-induced calcium influx and insulin release by a protein kinase-C-independent mechanism in HIT T-15 islet cells.
Topics: Alkaloids; Calcium; Calcium Channel Blockers; Cell Line; Diglycerides; Drug Synergism; Insulin; Islets of Langerhans; Potassium; Potassium Chloride; Protein Kinase C; Pyrimidinones; Staurosporine; Thiazoles | 1992 |
Sphingosine-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation.
Topics: 3T3 Cells; Animals; Diglycerides; Dose-Response Relationship, Drug; Enzyme Activation; Kinetics; Lysophospholipids; Mice; Phosphatidate Phosphatase; Phosphatidic Acids; Phospholipase D; Pyrimidinones; Sphingosine; Thiazoles | 1992 |
Phosphatidic acid that accumulates in platelet-derived growth factor-stimulated Balb/c 3T3 cells is a potential mitogenic signal.
Topics: 3T3 Cells; Animals; Antibody Specificity; Chromatography, Thin Layer; Diglycerides; Enzyme-Linked Immunosorbent Assay; Mice; Mice, Inbred BALB C; Mitogens; Phosphatidic Acids; Phospholipase D; Platelet-Derived Growth Factor; Propranolol; Pyrimidinones; Signal Transduction; Thiazoles; Type C Phospholipases | 1992 |
The effects of a diacylglycerol kinase inhibitor at mammalian and amphibian neuromuscular junctions in vitro.
Topics: Animals; Diacylglycerol Kinase; Diaphragm; Evoked Potentials; In Vitro Techniques; Kinetics; Mice; Mice, Inbred C57BL; Neuromuscular Junction; Phosphotransferases; Pyrimidinones; Rana temporaria; Thiazoles; Time Factors | 1991 |
The diacylglycerol kinase inhibitor, R59022, potentiates cholecystokinin-induced enzyme secretion from rabbit pancreatic acini.
Topics: Amylases; Animals; Calcimycin; Cholecystokinin; Diacylglycerol Kinase; Diglycerides; Dose-Response Relationship, Drug; Drug Synergism; Hydrolysis; Pancreas; Phorbol Esters; Phosphatidic Acids; Phosphotransferases; Protein Kinase C; Pyrimidinones; Rabbits; Thiazoles | 1990 |
Effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on substance P-induced histamine release from rat peritoneal mast cells.
Topics: Animals; Ascitic Fluid; Calcium; Cyclohexanones; Female; Histamine Release; In Vitro Techniques; Male; Mast Cells; Platelet Activating Factor; Pyrimidinones; Rats; Rats, Inbred Strains; Substance P; Tetradecanoylphorbol Acetate; Thiazoles | 1990 |
Effects of phorbol ester and cholecystokinin on the intracellular distribution of protein kinase C in rabbit pancreatic acini.
Topics: Amylases; Animals; Cell Fractionation; Diacylglycerol Kinase; Kinetics; Pancreas; Phosphotransferases; Protein Kinase C; Pyrimidinones; Rabbits; Sincalide; Subcellular Fractions; Tetradecanoylphorbol Acetate; Thiazoles | 1991 |
Crystal-induced neutrophil activation. I. Initiation and modulation of calcium mobilization and superoxide production by microcrystals.
Topics: Alkaloids; Calcium; Calcium Pyrophosphate; Carbazoles; Cholera Toxin; Colchicine; Crystallization; Cytochalasin B; Cytoplasm; Diacylglycerol Kinase; Drug Interactions; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Indole Alkaloids; Neutrophils; Oxidation-Reduction; Pertussis Toxin; Phosphotransferases; Protein Kinase C; Pyrimidinones; Staurosporine; Superoxides; Thiazoles; Uric Acid; Virulence Factors, Bordetella | 1991 |
Role of phosphatidic acid in carbachol-induced contraction in guinea pig Taenia coli.
Topics: Animals; Biological Transport, Active; Calcium; Carbachol; Colon; Diacylglycerol Kinase; Diglycerides; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Phosphatidic Acids; Phosphotransferases; Pyrimidinones; Thiazoles | 1991 |
Phosphatidic acid accumulation and catecholamine release in adrenal chromaffin cells: stimulation by high potassium and by nicotine, and effect of a diacylglycerol kinase inhibitor R 59 022.
Topics: Animals; Catecholamines; Cattle; Cells, Cultured; Chromaffin System; Dose-Response Relationship, Drug; Nicotine; Phosphatidic Acids; Platelet Activating Factor; Potassium; Pyrimidinones; Thiazoles | 1991 |
Involvement of protein kinase C in Ca(2+)-independent contraction of rat uterine smooth muscle.
Topics: Animals; Blotting, Western; Brain; Calcium; Electrophoresis, Polyacrylamide Gel; Female; In Vitro Techniques; Isoenzymes; Muscle Contraction; Muscle, Smooth; Oxytocin; Protein Kinase C; Pyrimidinones; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Thiazoles; Uterus | 1991 |
Alkaline buffers release EDRF from bovine cultured aortic endothelial cells.
Topics: Animals; Arginine; Buffers; Cattle; Cells, Cultured; Cyclohexanones; Endothelium, Vascular; Epoprostenol; Hydrogen-Ion Concentration; Lipoprotein Lipase; Nitric Oxide; omega-N-Methylarginine; Platelet Activating Factor; Pyrimidinones; Thiazoles | 1991 |
Influence of phorbol esters, and diacylglycerol kinase and lipase inhibitors on noradrenaline release and phosphoinositide hydrolysis in chromaffin cells.
Topics: Adrenal Medulla; Animals; Cattle; Cyclohexanones; Diacylglycerol Kinase; Hydrolysis; In Vitro Techniques; Lipoprotein Lipase; Norepinephrine; Phosphatidylinositols; Phosphotransferases; Pyrimidinones; Tetradecanoylphorbol Acetate; Thiazoles | 1990 |
PKC and Pi deprivation modulate differently the ubiquitous Na-dependent Pi uptake in MDCK cells.
Topics: Adaptation, Physiological; Animals; Cell Line; Diglycerides; Kidney Tubules; Phosphates; Protein Kinase C; Pyrimidinones; Sodium; Tetradecanoylphorbol Acetate; Thiazoles | 1991 |
Induction of gene expression by IL-1 in NIH 3T3 cells. Possible requirement of protein kinase C activity and independence from arachidonic acid metabolism.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cell Line; Cyclooxygenase Inhibitors; Dinoprostone; Gene Expression; Interleukin-1; Lipoxygenase Inhibitors; Mice; Protein Kinase C; Pyrimidinones; Recombinant Proteins; Tetradecanoylphorbol Acetate; Thiazoles; Transcription, Genetic; Tumor Necrosis Factor-alpha | 1990 |
Antagonism by the diacylglycerol kinase inhibitor R59 022 of muscarinic receptor-mediated cyclic GMP formation and binding of [3H]N-methylscopolamine.
Topics: Animals; Binding, Competitive; Carbachol; Cyclic GMP; Diacylglycerol Kinase; Mice; Muscarinic Antagonists; N-Methylscopolamine; Phosphotransferases; Pyrimidinones; Receptors, Muscarinic; Scopolamine Derivatives; Thiazoles; Tumor Cells, Cultured | 1990 |
Regulation of oxytocin secretion by the ovine corpus luteum: effect of activators of protein kinase C.
Topics: Animals; Bucladesine; Calcimycin; Corpus Luteum; Diglycerides; Dose-Response Relationship, Drug; Enzyme Activation; Female; In Vitro Techniques; Oxytocin; Phorbol 12,13-Dibutyrate; Platelet Activating Factor; Protein Kinase C; Pyrimidinones; Sheep; Tetradecanoylphorbol Acetate; Thiazoles; Type C Phospholipases | 1990 |
Fibroblast growth factor stimulates protein kinase C in quiescent 3T3 cells without Ca2+ mobilization or inositol phosphate accumulation.
Topics: Animals; Bombesin; Calcium; Cell Line; Cyclic AMP; Diacylglycerol Kinase; DNA; Electrophoresis, Gel, Two-Dimensional; Enzyme Activation; Epidermal Growth Factor; Fibroblast Growth Factors; Hydrogen-Ion Concentration; Inositol Phosphates; Mice; Phosphoproteins; Phosphotransferases; Platelet-Derived Growth Factor; Protein Kinase C; Pyrimidinones; Signal Transduction; Thiazoles | 1990 |
Muscarinic receptor antagonist activity of diacylglycerol lipase and kinase inhibitors.
Topics: Animals; Brain; Cells, Cultured; Cyclic GMP; Cyclohexanes; Cyclohexanones; Guinea Pigs; Heart; Lipoprotein Lipase; Myocardium; N-Methylscopolamine; Pancreas; Parasympatholytics; Platelet Activating Factor; Pyrimidinones; Rats; Receptors, Muscarinic; Scopolamine Derivatives; Thiazoles; Tritium | 1990 |
A central role for phosphoinositide hydrolysis in activating the lytic mechanism of human natural killer cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Cytosol; Cytotoxicity, Immunologic; Diacylglycerol Kinase; Humans; Hydrolysis; Inositol Phosphates; Isoquinolines; Killer Cells, Natural; Neomycin; Phosphatidylinositols; Phosphotransferases; Piperazines; Protein Kinase C; Pyrimidinones; Tetradecanoylphorbol Acetate; Thiazoles | 1990 |
A diacylglycerol kinase inhibitor, R 59 022, potentiates superoxide anion production and 46-kDa protein phosphorylation in guinea pig polymorphonuclear leukocytes.
Topics: Alkaloids; Animals; Diacylglycerol Kinase; Female; Guinea Pigs; Kinetics; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipids; Phosphoproteins; Phosphorylation; Phosphotransferases; Protein Kinase Inhibitors; Pyrimidinones; Staurosporine; Superoxides; Thiazoles | 1990 |
Diacylglycerol and phosphatidate production and the exocytosis of the sperm acrosome.
Topics: Acrosome; Animals; Calcimycin; Calcium; Diglycerides; Exocytosis; Kinetics; Male; Phosphates; Phosphatidic Acids; Phosphatidylinositols; Pyrimidinones; Sheep; Thiazoles | 1990 |
Effects of phorbol ester and related compounds on acetylcholine-evoked [3H]leucine-labelled protein secretion in permeabilized rat pancreatic acini.
Topics: Acetylcholine; Animals; Calcium; Cell Membrane Permeability; Cyclic GMP; Female; In Vitro Techniques; Inositol Phosphates; Male; Pancreas; Phospholipid Ethers; Polymyxin B; Proteins; Pyrimidinones; Rats; Tetradecanoylphorbol Acetate; Thiazoles | 1990 |
Growth hormone stimulates the formation of sn-1,2-diacylglycerol in rat hepatocytes.
Topics: Animals; Diacylglycerol Kinase; Diglycerides; Growth Hormone; Liver; Osmolar Concentration; Phosphotransferases; Pyrimidinones; Rats; Thiazoles; Time Factors | 1990 |
Key role of diacylglycerol-mediated 12-lipoxygenase product formation in angiotensin II-induced aldosterone synthesis.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Aldosterone; Angiotensin II; Animals; Arachidonate 12-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Cyclohexanones; Diacylglycerol Kinase; Diglycerides; Hydroxyeicosatetraenoic Acids; Lipoprotein Lipase; Male; Phosphotransferases; Pyrimidinones; Rats; Rats, Inbred Strains; Thiazoles; Zona Glomerulosa | 1990 |
Role of protein kinase C in the regulation of cytosolic Ca2+ in A431 cells: separation of growth factor and bradykinin pathways.
Topics: Alkaloids; Bradykinin; Calcium; Cytosol; Down-Regulation; Epidermal Growth Factor; Humans; Ionomycin; Manganese; Protein Kinase C; Pyrimidinones; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thiazoles; Transforming Growth Factor alpha; Tumor Cells, Cultured | 1990 |
Role of protein kinase C in chick embryo skeletal myoblast fusion.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alprostadil; Animals; Calcium; Cell Fusion; Chick Embryo; Diglycerides; Enzyme Activation; Isoquinolines; Muscles; Piperazines; Protein Kinase C; Protein Kinases; Pyrimidinones; Tetradecanoylphorbol Acetate; Thiazoles | 1990 |
Hypotonicity stimulates phosphatidylcholine hydrolysis and generates diacylglycerol in erythrocytes.
Topics: Animals; Diglycerides; Erythrocytes; Glycerides; Hydrolysis; Hypotonic Solutions; In Vitro Techniques; Kinetics; Phosphates; Phosphatidic Acids; Phosphatidylcholines; Phosphatidylethanolamines; Platelet Activating Factor; Pyrimidinones; Skates, Fish; Thiazoles | 1990 |
The actions of inhibitors of diacylglycerol kinase and diacylglycerol lipase on histamine release from rat peritoneal mast cells.
Topics: Animals; Cyclohexanones; Diacylglycerol Kinase; Histamine Release; In Vitro Techniques; Lipoprotein Lipase; Male; Mast Cells; Peritoneal Cavity; Phosphotransferases; Pyrimidinones; Rats; Rats, Inbred Strains; Thiazoles | 1987 |
Tentacle contraction in Heliophrya erhardi (Suctoria): the role of inositol phospholipid metabolites and cyclic nucleotides in stimulus-response coupling.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Chlorides; Ciliophora; Cyclic AMP; Cyclic GMP; Dibutyryl Cyclic GMP; Inositol Phosphates; Lithium; Lithium Chloride; Muscle Contraction; Pyrimidinones; Sugar Phosphates; Tetradecanoylphorbol Acetate; Thiazoles | 1988 |
The diacylglycerol kinase inhibitor, R 59022, suppresses contractility of intestinal smooth muscle.
Topics: Acetylcholine; Animals; Calcium; Diacylglycerol Kinase; Female; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Phosphatidylinositols; Phosphotransferases; Platelet Activating Factor; Pyrimidinones; Substance P; Thiazoles | 1989 |
Chemoattractant-induced cytoplasmic pH changes and cytoskeletal reorganization in human neutrophils. Relationship to the stimulated calcium transients and oxidative burst.
Topics: Actins; Binding, Competitive; Calcimycin; Calcium; Chemotactic Factors; Cytoplasm; Egtazic Acid; Humans; Leukotriene B4; Macromolecular Substances; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Onium Compounds; Oxygen Consumption; Pyrimidinones; Superoxides; Thiazoles | 1989 |
Inhibitors of 1,2-diacylglycerol kinase potentiate the TRH-induced stimulation of Ca2+-activated K+ current.
Topics: Calcium; Calcium Channels; Clone Cells; Diacylglycerol Kinase; Phosphotransferases; Platelet Activating Factor; Potassium Channels; Pyrimidinones; Thiazoles; Thyrotropin-Releasing Hormone; Vanadates | 1989 |
Diacylglycerol kinase inhibitors R59022 and dioctanoylethylene glycol potentiate the respiratory burst of neutrophils by raising cytosolic Ca2+.
Topics: Calcium; Cell Membrane Permeability; Cytosol; Diacylglycerol Kinase; Drug Synergism; Ethylene Glycols; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen Consumption; Phosphotransferases; Pyrimidinones; Thiazoles | 1989 |
Different effects of sphingosine, R59022 and anionic amphiphiles on two diacylglycerol kinase isozymes purified from porcine thymus cytosol.
Topics: Animals; Chromatography, Ion Exchange; Cytosol; Deoxycholic Acid; Diacylglycerol Kinase; Electrophoresis, Polyacrylamide Gel; Isoenzymes; Kinetics; Phosphatidylserines; Phosphotransferases; Pyrimidinones; Sphingosine; Swine; Thiazoles; Thymus Gland | 1989 |
Diacylglycerol in the synergy of bradykinin and thrombin stimulation of prostaglandin synthesis.
Topics: Animals; Bradykinin; Cyclohexanones; Diacylglycerol Kinase; Diglycerides; Dinoprostone; Drug Synergism; Fibroblasts; Glycerides; Mice; Mice, Inbred BALB C; Phosphotransferases; Pyrimidinones; Thiazoles; Thrombin; Time Factors | 1989 |
Effects of bradykinin, GTP gamma S, R59022 and N-ethylmaleimide on inositol phosphate production in NG108-15 cells.
Topics: Animals; Bradykinin; Cell Line; Drug Interactions; Ethylmaleimide; Glioma; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Hybrid Cells; Inositol; Inositol Phosphates; Kinetics; Mice; Neuroblastoma; Platelet Activating Factor; Pyrimidinones; Rats; Thiazoles; Thionucleotides | 1989 |
Bradykinin-induced translocation of protein kinases C in neuroblastoma NCB-20 cell: dependence on 1,2-diacylglycerol content and free calcium.
Topics: Animals; Bradykinin; Calcium; Cell Compartmentation; Diglycerides; Glycerides; Humans; Hybrid Cells; Isoenzymes; Neuroblastoma; Phorbol 12,13-Dibutyrate; Protein Kinase C; Pyrimidinones; Thiazoles; Time Factors; Tumor Cells, Cultured | 1989 |
Triwaglerin: a potent platelet aggregation inducer purified from Trimeresurus wagleri snake venom.
Topics: Animals; Calcium Channel Blockers; Chromatography, Affinity; Chromatography, Gel; Chromatography, Ion Exchange; Colforsin; Crotalid Venoms; Electrophoresis, Disc; Esterases; Indomethacin; Kinetics; Nitroprusside; Peptides; Platelet Aggregation; Pyrimidinones; Rabbits; Species Specificity; Tetracaine; Thiazoles | 1989 |
A role of diacylglycerol kinase in stimulus-secretion coupling of human platelets. Dissociation of serotonin secretion from Ca2+ mobilization.
Topics: Aminoquinolines; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcium; Diacylglycerol Kinase; Enzyme Inhibitors; Humans; Phosphotransferases; Platelet Aggregation; Pyrimidinones; Serotonin; Thiazoles; Thrombin | 1987 |
A diacylglycerol kinase inhibitor, R59022, potentiates secretion by and aggregation of thrombin-stimulated human platelets.
Topics: Blood Platelets; Calcimycin; Calcium; Diacylglycerol Kinase; Diglycerides; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Phosphatidic Acids; Phosphorylation; Phosphotransferases; Platelet Aggregation; Pyrimidinones; Serotonin; Thiazoles; Thrombin | 1987 |
Comparison of the effects of indomethacin, RHC80267 and R59022 on superoxide production by 1,oleoyl-2,acetyl glycerol and A23187 in human neutrophils.
Topics: Angiotensin-Converting Enzyme Inhibitors; Calcimycin; Cyclohexanes; Cyclohexanones; Diglycerides; Glycerides; Humans; In Vitro Techniques; Indomethacin; Kinetics; Neutrophils; Platelet Activating Factor; Pyrimidinones; Superoxides; Thiazoles | 1987 |
The diacylglycerol kinase inhibitor R59022 potentiates superoxide production but not secretion induced by fMet-Leu-Phe: effects of leupeptin and the protein kinase C inhibitor H-7.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cytochalasin B; Diacylglycerol Kinase; Isoquinolines; Kinetics; Leupeptins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Phosphotransferases; Piperazines; Platelet Activating Factor; Protein Kinase C; Pyrimidinones; Rabbits; Superoxides; Thiazoles | 1987 |
Diacylglycerol kinase inhibitor, R59022, potentiates neutrophil oxidase activation by Ca2+-dependent stimuli. Evidence for two separate but convergent pathways.
Topics: Animals; Calcimycin; Calcium; Diacylglycerol Kinase; Enzyme Activation; Gossypol; Luminescent Measurements; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxidoreductases; Phosphotransferases; Protein Kinase C; Pyrimidinones; Rats; Thiazoles | 1987 |
Protein kinase C mediates human neutrophil cytotoxicity.
Topics: Cytotoxicity, Immunologic; Diacylglycerol Kinase; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphotransferases; Protein Kinase C; Pyrimidinones; Tetradecanoylphorbol Acetate; Thiazoles | 1987 |
Differential effects of the diacylglycerol kinase inhibitor R59022 on thrombin versus collagen-induced human platelet secretion.
Topics: Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcium; Collagen; Diacylglycerol Kinase; Diglycerides; Dose-Response Relationship, Drug; Ethers; Glycerides; Humans; Ionomycin; Phosphoproteins; Phosphotransferases; Platelet Aggregation; Pyrimidinones; Serotonin; Tetradecanoylphorbol Acetate; Thiazoles; Thrombin | 1988 |
Receptor-mediated release of endothelium-derived relaxing factor and prostacyclin from bovine aortic endothelial cells is coupled.
Topics: Animals; Aorta; Biological Products; Cattle; Endothelium, Vascular; Enzyme Activation; Epoprostenol; Gentamicins; Methylene Blue; Nitric Oxide; Pyrimidinones; Receptors, Cell Surface; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Thiazoles; Type C Phospholipases | 1988 |
[3H]phosphatidic acid formed in response to FMLP is not inhibited by R59 022, a diacylglycerol kinase inhibitor.
Topics: Diacylglycerol Kinase; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphatidic Acids; Phosphatidylinositols; Phosphotransferases; Pyrimidinones; Thiazoles | 1988 |
The effect of inhibition of both diacylglycerol metabolism and phospholipase A2 activity on superoxide generation by human neutrophils.
Topics: Cyclohexanones; Diacylglycerol Kinase; Humans; Indomethacin; Lipoprotein Lipase; Meclofenamic Acid; Neutrophils; Phospholipases; Phospholipases A; Phospholipases A2; Phosphotransferases; Pyrimidinones; Sodium Fluoride; Superoxides; Thiazoles | 1988 |
The inhibition of arachidonic acid mobilization in human platelets by R59 022, a diacylglycerol kinase inhibitor.
Topics: Arachidonic Acid; Arachidonic Acids; Blood Platelets; Diacylglycerol Kinase; Humans; In Vitro Techniques; Membrane Lipids; Phosphatidylethanolamines; Phosphatidylserines; Phospholipases A; Phospholipases A2; Phospholipids; Phosphotransferases; Platelet Aggregation; Pyrimidinones; Thiazoles; Thrombin | 1988 |
Diacylglycerol kinase inhibitor R59022 and stimulated neutrophil responses.
Topics: Animals; Diacylglycerol Kinase; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphatidic Acids; Phosphotransferases; Protein Kinases; Pyrimidinones; Rabbits; Stimulation, Chemical; Superoxides; Thiazoles | 1988 |
Increased protein synthesis response to insulin in fibroblasts treated with the diacylglycerol kinase inhibitor R59022.
Topics: Animals; Cells, Cultured; Diacylglycerol Kinase; Fibroblasts; Insulin; Kinetics; Mice; Phosphotransferases; Protein Biosynthesis; Protein Synthesis Inhibitors; Pyrimidinones; Thiazoles | 1988 |
Histaminergic stimulation of prolactin secretion mediated via H1- or H2-receptors: dependence on routes of administration.
Topics: Animals; Cimetidine; Dimaprit; Histamine; Histamine H1 Antagonists; Male; Methylhistamines; Pituitary Gland, Anterior; Prolactin; Pyrilamine; Pyrimidinones; Rats; Receptors, Histamine; Thiazoles; Thiourea | 1986 |
7-trans-(2-Pyridylethenyl)-5H-thiazolo[3,2-a]pyrimidine-5-ones: synthesis and pharmacological activity.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Arthus Reaction; Chemical Phenomena; Chemistry; Gastric Mucosa; Male; Parasympatholytics; Pyridines; Pyrimidinones; Rats; Rats, Inbred Strains; Thiazoles | 1985 |
R 59 022, a diacylglycerol kinase inhibitor. Its effect on diacylglycerol and thrombin-induced C kinase activation in the intact platelet.
Topics: Blood Platelets; Calcium; Diacylglycerol Kinase; Diglycerides; Dose-Response Relationship, Drug; Enzyme Activation; Erythrocyte Membrane; Glycerides; Humans; Magnesium; Molecular Weight; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Phosphorylation; Phosphotransferases; Potassium; Protein Kinase C; Pyrimidinones; Sodium; Thiazoles; Thrombin | 1985 |
The diacylglycerol kinase inhibitor, R59022, enhances the superoxide generation from human neutrophils induced by stimulation of fMet-Leu-Phe, IgG and C3b receptors.
Topics: Cyclohexanones; Diacylglycerol Kinase; Diglycerides; Humans; In Vitro Techniques; Lipoprotein Lipase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphotransferases; Protein Kinase C; Pyrimidinones; Receptors, Complement; Receptors, Complement 3b; Receptors, Fc; Receptors, Formyl Peptide; Receptors, Immunologic; Superoxides; Thiazoles | 1987 |
Evidence for the involvement of PI-signaling and diacylglycerol second messengers in the initiation of metamorphosis in the hydroid Hydractinia echinata Fleming.
Topics: Animals; Diacylglycerol Kinase; Diglycerides; Glycerides; Hydra; Inositol Phosphates; Metamorphosis, Biological; Phosphatidylinositols; Phosphotransferases; Pyrimidinones; Sugar Phosphates; Thiazoles | 1987 |
Thrombin and C-kinase activators potentiate calcium-stimulated arachidonic acid release in human platelets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcium; Diglycerides; Diterpenes; Drug Synergism; Humans; Isoquinolines; Phospholipids; Piperazines; Protein Kinase C; Pyrimidinones; Terpenes; Tetradecanoylphorbol Acetate; Thiazoles; Thrombin | 1987 |
Effects of inhibitors of diacylglycerol metabolism on protein kinase C-mediated responses in hepatocytes.
Topics: Animals; Calcium; Caprylates; Diglycerides; Enzyme Activation; Epinephrine; Glucagon; Glycerides; Glycogen Synthase; In Vitro Techniques; Liver; Phosphorylases; Protein Kinase C; Pyrimidinones; Thiazoles; Vasopressins | 1988 |
The diacylglycerol kinase inhibitor R 59022 potentiates bombesin stimulation of protein kinase C activity and DNA synthesis in Swiss 3T3 cells.
Topics: Animals; Bombesin; Cell Line; DNA Replication; Drug Synergism; Epidermal Growth Factor; Mice; Phosphoproteins; Protein Kinase C; Pyrimidinones; Thiazoles | 1988 |
Phorbol esters inhibit adenylate cyclase activity in cultured collecting tubular cells.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Cells, Cultured; Diglycerides; Kidney Tubules; Kidney Tubules, Collecting; Phorbol Esters; Protein Kinase C; Pyrimidinones; Rabbits; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Thiazoles; Vasopressins | 1988 |
Differential effects of various protein kinase C activators on protein phosphorylation in human acute myeloblastic leukemia cell line KG-1 and its phorbol ester-resistant subline KG-1a.
Topics: Bryostatins; Cell Differentiation; Cell Line; Diglycerides; Diterpenes; Drug Resistance; Enzyme Activation; Humans; Lactones; Leukemia, Myeloid, Acute; Macrolides; Phosphorylation; Protein Kinase C; Proteins; Pyrimidinones; Terpenes; Tetradecanoylphorbol Acetate; Thiazoles | 1987 |
Mesoionic purinone analogs. IV. Synthesis and in vitro antibacterial properties of mesoionic thiazolo(3,2-a)pyrimidin-5,7-diones and mesoionic 1,3,4-thiadizolo(3,2-a)pyrimidin-5,7-diones.
Topics: Anti-Bacterial Agents; Bacillus subtilis; Enterococcus faecalis; Escherichia coli; Methods; Microbial Sensitivity Tests; Proteus vulgaris; Pseudomonas aeruginosa; Pseudomonas fluorescens; Pyrimidinones; Staphylococcus; Thiadiazoles; Thiazoles | 1973 |
Heterocyclics from malonyl chlorides. 3. Cyclisation and oxidation of some 2-alkylthiopyrimidones.
Topics: Chemical Phenomena; Chemical Precipitation; Chemistry; Chlorine; Halogens; Heterocyclic Compounds; Malonates; Methods; Pyrimidinones; Spectrum Analysis; Sulfoxides; Thiazines; Thiazoles | 1972 |
A novel thiazole synthesis. 4,5,6,7-tetrahydrothiazolo[4,5-d]pyrimidine-5,7-diones.
Topics: Pyridines; Pyrimidinones; Thiazoles; Uracil | 1969 |
Benz-fused mesoionic xanthine analogues as inhibitors of cyclic-AMP phosphodiesterase.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cattle; In Vitro Techniques; Pyrimidinones; Structure-Activity Relationship; Thiazoles | 1981 |
Chemical, pharmacological and oncostatic properties of 5-(4'-hydroxybenzylidenoimino)-4, 6-diketo-4, 5, 6, 7-tetrahydropyrimidine-[4, 5-d]-3-methyl-isothiazole (compound IP-10).
Topics: Animals; Antineoplastic Agents; Blood Cells; Bone Marrow; Carcinoma, Ehrlich Tumor; Cats; Central Nervous System; Chick Embryo; Dogs; Female; Guinea Pigs; Hemodynamics; Lethal Dose 50; Leukemia, Experimental; Lung Neoplasms; Male; Mass Spectrometry; Melanoma; Mice; Mice, Inbred Strains; Pyrimidinones; Rabbits; Rats; Rats, Inbred Strains; Sarcoma, Yoshida; Spectrophotometry, Infrared; Thiazoles | 1983 |
Induction of photoresponse by the hydrolysis of polyphosphoinositides in the Hermissenda type B photoreceptor.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Cyclic GMP; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Hydrolysis; Inositol 1,4,5-Trisphosphate; Kinetics; Lithium Chloride; Models, Biological; Neomycin; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Photoreceptor Cells, Invertebrate; Platelet Activating Factor; Pyrimidinones; Snails; Spermine; Thiazoles; Thionucleotides; Type C Phospholipases | 1994 |
Effect of R59022, an inhibitor of diacylglycerol kinase, on IgE-mediated histamine release from human lung mast cells and basophils.
Topics: Basophils; Cell Count; Cells, Cultured; Diacylglycerol Kinase; Fluorometry; Histamine Release; Humans; Immunoglobulin E; Lung; Mast Cells; Phosphotransferases (Alcohol Group Acceptor); Pyrimidinones; Thiazoles | 1994 |
Early signalling events implicated in leukotriene B4-induced activation of the NADPH oxidase in eosinophils: role of Ca2+, protein kinase C and phospholipases C and D.
Topics: Animals; Calcium; Chelating Agents; Diacylglycerol Kinase; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Eosinophils; Guinea Pigs; Humans; Hydrogen Peroxide; Indoles; Kinetics; Leukotriene B4; NADH, NADPH Oxidoreductases; NADPH Oxidases; Phorbol 12,13-Dibutyrate; Phospholipase D; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Pyrimidinones; Serum Albumin; Signal Transduction; Thiazoles; Type C Phospholipases | 1995 |
IL-8 enhances antibody-dependent cellular cytotoxicity in human neutrophils.
Topics: Adjuvants, Immunologic; Alkaloids; Anions; Antibody-Dependent Cell Cytotoxicity; Diacylglycerol Kinase; Humans; Interleukin-8; Neutrophil Activation; Neutrophils; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Pyrimidinones; Respiratory Burst; Staurosporine; Superoxides; Thiazoles | 1995 |
Synthesis and antimicrobial activity of novel aminopyrimidinedione and aminothiazolidindione derivatives.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bacteria; Escherichia coli; Microbial Sensitivity Tests; Pyrimidinones; Saccharomyces cerevisiae; Staphylococcus; Staphylococcus aureus; Thiazoles | 1995 |
Time-course changes in content and fatty acid composition of phosphatidic acid from rat thymocytes during concanavalin A stimulation.
Topics: Animals; Arachidonic Acid; Concanavalin A; Diacylglycerol Kinase; Diglycerides; Fatty Acids; Fatty Acids, Unsaturated; Lymphocyte Activation; Male; Membrane Lipids; Phosphatidic Acids; Phosphotransferases (Alcohol Group Acceptor); Pyrimidinones; Rats; Rats, Sprague-Dawley; Signal Transduction; Thiazoles; Thymus Gland; Time Factors | 1995 |
Diacylglycerol in peripheral blood neutrophils from patients with localized juvenile periodontitis.
Topics: Adolescent; Adult; Aggressive Periodontitis; Case-Control Studies; Chemotaxis, Leukocyte; Cytochalasin B; Diacylglycerol Kinase; Diglycerides; Female; Humans; Luminescent Measurements; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Pyrimidinones; Receptors, Immunologic; Respiratory Burst; Second Messenger Systems; Thiazoles; Zymosan | 1994 |
Participation of diacylglycerol kinase in mitogenic signal transduction induced by platelet-derived growth factor in vascular smooth muscle cells.
Topics: Alkaloids; Analysis of Variance; Animals; Aorta, Thoracic; Arachidonic Acid; Becaplermin; Cell Division; Cells, Cultured; Diacylglycerol Kinase; DNA; Enzyme Activation; Genistein; Humans; Isoflavones; Mitogens; Muscle, Smooth, Vascular; Myristic Acid; Myristic Acids; Phospholipase D; Phosphotransferases (Alcohol Group Acceptor); Platelet Activating Factor; Platelet-Derived Growth Factor; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-sis; Pyrimidinones; Rats; Recombinant Proteins; Signal Transduction; Staurosporine; Thiazoles | 1994 |
Activation of diacylglycerol kinase by carbachol in guinea pig taenia coli.
Topics: Animals; Calcium; Carbachol; Colon; Diacylglycerol Kinase; Diglycerides; Dose-Response Relationship, Drug; Enzyme Activation; Guinea Pigs; Phosphatidic Acids; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Pyrimidinones; Thiazoles | 1994 |
Characterization of eosinophil homotypic aggregation.
Topics: Animals; Calcium; CD18 Antigens; Cell Aggregation; Drug Synergism; Eosinophils; Guinea Pigs; Leukotriene B4; Magnesium; Microscopy; Platelet Activating Factor; Pyrimidinones; Stimulation, Chemical; Superoxides; Thiazoles | 1995 |
Antisecretory effects of a novel and long-lasting histamine H2-receptor antagonist, YM-14471, in rats and dogs.
Topics: Animals; Cimetidine; Dogs; Dose-Response Relationship, Drug; Famotidine; Gastric Acid; Guinea Pigs; Heart Atria; Heart Rate; Histamine; Histamine H2 Antagonists; Infusions, Intravenous; Male; Omeprazole; Pyrimidinones; Rats; Rats, Wistar; Thiazoles | 1993 |
Diacylglycerol kinase activity in rat liver nuclei.
Topics: Animals; Cell Nucleus; Detergents; Diacylglycerol Kinase; Enzyme Activation; Enzyme Inhibitors; Enzyme Stability; Liver; Male; Microsomes, Liver; Phosphotransferases (Alcohol Group Acceptor); Platelet Activating Factor; Pyrimidinones; Rats; Rats, Sprague-Dawley; Substrate Specificity; Thiazoles | 1994 |
Cellular mechanisms mediating the stimulation of ovine endometrial secretion of prostaglandin F2 alpha in response to oxytocin: role of phospholipase C and diacylglycerol.
Topics: Animals; Arginine Vasopressin; Diglycerides; Dinoprost; Endometrium; Enzyme Activation; Estrenes; Female; In Vitro Techniques; Indoles; Lactams; Lithium Chloride; Ovariectomy; Oxytocin; Pyrimidinones; Pyrrolidinones; Sheep; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Thiazoles; Time Factors; Type C Phospholipases | 1994 |
Arachidonate activation of protein kinase C may be involved in the stimulation of protein synthesis by insulin in L6 myoblasts.
Topics: Animals; Arachidonic Acid; Cell Line; Cyclohexanones; Cyclooxygenase Inhibitors; Diglycerides; Enzyme Activation; Indoles; Insulin; Lipoprotein Lipase; Muscle Proteins; Muscles; Protein Kinase C; Pyrimidinones; Rats; Thiazoles | 1993 |
Effect of diacylglycerol kinase inhibitor, R59022 on cytosolic free calcium level and force development in guinea pig taenia coli.
Topics: Animals; Calcium; Colon; Guinea Pigs; Muscle Contraction; Platelet Activating Factor; Pyrimidinones; Thiazoles | 1993 |
Activation of neutrophil migration by dioctanoyl-sn-glycerol and fMet-Leu-Phe is controlled by different pathways.
Topics: Animals; Chemotaxis, Leukocyte; Diglycerides; Glyceryl Ethers; Guanosine 5'-O-(3-Thiotriphosphate); Macrophage Activation; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Protein Kinase C; Pyrimidinones; Rabbits; Thiazoles | 1993 |
Early cell cycle diacylglycerol (DAG) content and protein kinase C (PKC) activity enhancement potentiates prostaglandin F2 alpha (PGF2 alpha) induced mitogenesis in Swiss 3T3 cells.
Topics: 3T3 Cells; Animals; Cell Cycle; Cell Division; Diacylglycerol Kinase; Diglycerides; Dinoprost; DNA Replication; Insulin; Mice; Phosphorylation; Phosphotransferases; Protein Kinase C; Pyrimidinones; Thiazoles | 1993 |
Characterization of two cytosolic diacylglycerol kinase forms.
Topics: Adenosine Monophosphate; Amino Acids; Animals; Brain; Chromatography, DEAE-Cellulose; Cytosol; Diacylglycerol Kinase; Enzyme Activation; Isoenzymes; Molecular Weight; Phospholipids; Phosphorylation; Phosphotransferases; Pyrimidinones; Rats; Thiazoles | 1993 |
Activation of phospholipase C and protein kinase C has little involvement in ADP-induced primary aggregation of human platelets: effects of diacylglycerols, the diacylglycerols, the diacylglycerol kinase inhibitor R59022, staurosporine and okadaic acid.
Topics: Adenosine Diphosphate; Alkaloids; Blood Platelets; Diacylglycerol Kinase; Diglycerides; Enzyme Activation; Ethers, Cyclic; Humans; Okadaic Acid; Phosphotransferases; Platelet Aggregation; Protein Kinase C; Pyrimidinones; Serotonin; Staurosporine; Thiazoles; Thrombin; Type C Phospholipases | 1993 |
Mechanism and regulation of neutrophil priming by platelet-activating factor.
Topics: Adult; Amiloride; Azepines; Calcium; Chelating Agents; Diacylglycerol Kinase; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phosphotransferases; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Pyrimidinones; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Tetradecanoylphorbol Acetate; Thiazoles; Triazoles; Type C Phospholipases; Virulence Factors, Bordetella | 1993 |
Neutrophil chemotaxis induced by the diacylglycerol kinase inhibitor R59022.
Topics: Animals; Chemotaxis; Diacylglycerol Kinase; GTP-Binding Proteins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phosphotransferases; Protein Kinase C; Pyrimidinones; Rabbits; Thiazoles; Virulence Factors, Bordetella | 1993 |
Platelet-activating factor stimulates phosphatidic acid formation in cultured rat mesangial cells: roles of phospholipase D, diglyceride kinase, and de novo phospholipid synthesis.
Topics: Animals; Cells, Cultured; Choline; Diacylglycerol Kinase; Ethanolamines; Glomerular Mesangium; Glycerol; Hydrolysis; Male; Phosphatidic Acids; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipase D; Phospholipids; Phosphorus Radioisotopes; Phosphotransferases; Platelet Activating Factor; Pyrimidinones; Rats; Rats, Sprague-Dawley; Thiazoles; Time Factors; Tritium | 1993 |
ICI 169,369, A 5-HT2/5-HT1C antagonist, that can evoke endothelium-dependent relaxation in rabbit aorta.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Endothelium, Vascular; In Vitro Techniques; Kinetics; Muscle Relaxation; Nitric Oxide; Platelet Activating Factor; Pyrimidinones; Quinolines; Rabbits; Serotonin Antagonists; Thiazoles; Vasodilator Agents | 1993 |
Erythropoietin stimulates G-protein-coupled phospholipase D in haematopoietic target cells.
Topics: Adenosine Triphosphate; Animals; Cell Line; Cell Membrane; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Diglycerides; DNA; Enzyme Activation; Enzyme Inhibitors; Erythropoietin; Ethanol; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Hematopoietic Stem Cells; Kinetics; Membranes; Mice; Phosphatidic Acids; Phospholipase D; Phospholipids; Phosphorylation; Propranolol; Pyrimidinones; Thiazoles; Thionucleotides; Thymidine | 1996 |
Analysis of R59022 actions in Xenopus laevis oocytes.
Topics: Adenylyl Cyclases; Animals; Diacylglycerol Kinase; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Hydrogen-Ion Concentration; Meiosis; Oocytes; Oogenesis; Papaverine; Phosphodiesterase Inhibitors; Phosphotransferases (Alcohol Group Acceptor); Progesterone; Protein Serine-Threonine Kinases; Pyrimidinones; Ribosomal Protein S6 Kinases; Thiazoles; Xenopus laevis | 1996 |
Phosphatidic acid generation through interleukin 2 (IL-2)-induced alpha-diacylglycerol kinase activation is an essential step in IL-2-mediated lymphocyte proliferation.
Topics: Cell Compartmentation; Cell Cycle; Cells, Cultured; Diacylglycerol Kinase; Enzyme Activation; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Humans; Interleukin-2; Lymphocyte Activation; Phosphatidic Acids; Phosphotransferases (Alcohol Group Acceptor); Pyrimidinones; Receptors, Interleukin-2; Signal Transduction; T-Lymphocytes; Thiazoles | 1996 |
Ca2+ mobilizing action of sphingosine in Jurkat human leukemia T cells. Evidence that sphingosine releases Ca2+ from inositol trisphosphate- and phosphatidic acid-sensitive intracellular stores through a mechanism independent of inositol trisphosphate.
Topics: Amines; Calcium; Cell Line; Ceramides; Diacylglycerol Kinase; Diglycerides; Enzyme Inhibitors; Humans; Inositol 1,4,5-Trisphosphate; Kinetics; Leukemia, T-Cell; Models, Biological; Muromonab-CD3; Phosphatidic Acids; Phosphotransferases (Alcohol Group Acceptor); Psychosine; Pyrimidinones; Sphingosine; Terpenes; Thapsigargin; Thiazoles; Tumor Cells, Cultured | 1996 |
Relationship among cellular diacylglycerol, sphingosine formation, protein kinase C activity, and parathyroid hormone secretion from dispersed bovine parathyroid cells.
Topics: Animals; Calcium; Cattle; Diacylglycerol Kinase; Diglycerides; Enzyme Inhibitors; Parathyroid Glands; Parathyroid Hormone; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Pyrimidinones; Sphingosine; Tetradecanoylphorbol Acetate; Thiazoles | 1996 |
Electromagnetic field induced changes in lipid second messengers.
Topics: Cell Line; Choline; Diglycerides; Electromagnetic Fields; Enzyme Inhibitors; Ethanol; Flow Cytometry; Humans; Lipids; Molecular Structure; Phosphatidate Phosphatase; Phosphatidic Acids; Phospholipase D; Phospholipids; Phosphorylcholine; Propranolol; Pyrimidinones; Second Messenger Systems; Thiazoles; Time Factors; Tritium | 1996 |
The role of diacylglycerol and activation of protein kinase C in alpha 1A-adrenoceptor-mediated contraction to noradrenaline of rat isolated epididymal vas deferens.
Topics: Animals; Calcium; Carcinogens; Cyclohexanones; Diglycerides; Lipoprotein Lipase; Male; Naphthalenes; Norepinephrine; Phorbol 12,13-Dibutyrate; Platelet Activating Factor; Protein Kinase C; Pyrimidinones; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Staurosporine; Thiazoles; Vas Deferens | 1996 |
Subcellular localization of diacylglycerol kinase activity in stimulated and unstimulated human peripheral blood lymphocytes and neutrophils.
Topics: Cell Membrane; Cytosol; Diacylglycerol Kinase; Enzyme Inhibitors; Humans; Lymphocytes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphotransferases (Alcohol Group Acceptor); Phytohemagglutinins; Pyrimidinones; Thiazoles | 1996 |
Positron emission tomographic analysis of central 5-hydroxytryptamine2 receptor occupancy in healthy volunteers treated with the novel antipsychotic agent, ziprasidone.
Topics: Adult; Antipsychotic Agents; Brain Chemistry; Cerebrovascular Circulation; Humans; Male; Piperazines; Pyrimidinones; Receptors, Serotonin; Serotonin Antagonists; Thiazoles; Tomography, Emission-Computed | 1996 |
Exogenous diacylglycerols synergize with PAF with human platelets, but inhibit PAF-induced responses of rabbit platelets.
Topics: Animals; Blood Platelets; Cell Membrane Permeability; Diacylglycerol Kinase; Diglycerides; Drug Synergism; Enzyme Inhibitors; Humans; Phosphotransferases (Alcohol Group Acceptor); Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrimidinones; Rabbits; Thiazoles | 1996 |
Effects of the diacylglycerol kinase inhibitor, R59022, on TSH-stimulated iodide organification in porcine thyroid cells.
Topics: Animals; Cells, Cultured; Diacylglycerol Kinase; Enzyme Inhibitors; Iodine; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Pyrimidinones; Swine; Thiazoles; Thyroid Gland; Thyrotropin; Time Factors | 1996 |
Highly selective aldose reductase inhibitors. 3. Structural diversity of 3-(arylmethyl)-2,4,5-trioxoimidazolidine-1-acetic acids.
Topics: Acetates; Aldehyde Reductase; Animals; Benzothiazoles; Diabetes Complications; Enzyme Inhibitors; Humans; Imidazoles; Kidney; Lens, Crystalline; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Phthalazines; Pyrimidinones; Rats; Sorbitol; Structure-Activity Relationship; Thiazoles | 1997 |
Use of a fluorescent analog of CDP-DAG in human skin fibroblasts: characterization of metabolism, distribution, and application to studies of phosphatidylinositol turnover.
Topics: 4-Chloro-7-nitrobenzofurazan; Cells, Cultured; Chromatography, Thin Layer; Cyclohexanones; Cytidine Diphosphate Diglycerides; Enzyme Inhibitors; Fibroblasts; Fluorescent Dyes; Humans; Interleukin-1; Lipoprotein Lipase; Membrane Lipids; Microscopy, Fluorescence; Oleic Acid; Palmitic Acid; Phosphatidic Acids; Phosphatidylcholines; Phosphatidylinositols; Platelet-Derived Growth Factor; Propranolol; Pyrimidinones; Thiazoles | 1997 |
Contribution of PKC to beta-hexosaminidase-induced airway smooth muscle proliferation.
Topics: Animals; beta-N-Acetylhexosaminidases; Cattle; Cell Count; Cell Division; Diacylglycerol Kinase; Enzyme Inhibitors; Hexosaminidase A; Insulin; Muscle, Smooth; Naphthalenes; Phenylisopropyladenosine; Phosphotransferases (Alcohol Group Acceptor); Platelet-Derived Growth Factor; Protein Kinase C; Pyrimidinones; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Thiazoles; Thymidine; Trachea | 1997 |
ATP- and EGF-stimulated phosphatidulinositol synthesis by two different pathways, phospholipase D and diacylglycerol kinase, in A-431 epidermoid carcinoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Bradykinin; Calcimycin; Calcium; Carcinoma, Squamous Cell; Chelating Agents; Choline; Diacylglycerol Kinase; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Ionophores; Neoplasm Proteins; Pertussis Toxin; Phosphatidic Acids; Phosphatidylinositol Diacylglycerol-Lyase; Phosphatidylinositols; Phospholipase D; Phosphotransferases (Alcohol Group Acceptor); Pyrimidinones; Receptors, Purinergic P2; Signal Transduction; Staurosporine; Sulfonamides; Thiazoles; Tumor Cells, Cultured; Type C Phospholipases; Virulence Factors, Bordetella | 1996 |
Leukaemia inhibitory factor induces mitogenesis in Swiss 3T3 cells and selective enhancement via a variety of signalling events.
Topics: 3T3 Cells; Alprostadil; Animals; Diacylglycerol Kinase; Dinoprost; DNA; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Growth Inhibitors; Insulin; Interleukin-6; Leukemia Inhibitory Factor; Lymphokines; Mice; Mitosis; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Pyrimidinones; Signal Transduction; Tetradecanoylphorbol Acetate; Thiazoles; Transforming Growth Factor beta | 1997 |
The synergistic effects of vitamin D metabolites and transforming growth factor-beta on costochondral chondrocytes are mediated by increases in protein kinase C activity involving two separate pathways.
Topics: 24,25-Dihydroxyvitamin D 3; Alkaline Phosphatase; Animals; Calcitriol; Cartilage; Cells, Cultured; Cholera Toxin; Chondrocytes; Diacylglycerol Kinase; Drug Synergism; Enzyme Inhibitors; Protein Kinase C; Pyrimidinones; Rats; Ribs; Sulfates; Thiazoles; Thymidine; Transforming Growth Factor beta; Virulence Factors, Bordetella | 1998 |
Synthesis and anti-HIV-1 activity of novel 2,3-dihydro-7H-thiazolo[3,2-a]pyrimidin-7-ones.
Topics: Alkylation; Anti-HIV Agents; Cell Line; HIV Reverse Transcriptase; HIV-1; Humans; Magnetic Resonance Spectroscopy; Mesylates; Pyrimidines; Pyrimidinones; Reverse Transcriptase Inhibitors; T-Lymphocytes; Thiazoles; Thymine; Uracil; Virus Replication | 1998 |
New azole antifungals. 2. Synthesis and antifungal activity of heterocyclecarboxamide derivatives of 3-amino-2-aryl-1-azolyl-2-butanol.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Candidiasis; Colony Count, Microbial; Fungi; Male; Mice; Molecular Conformation; Pyrimidinones; Rats; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Thiophenes; Triazoles | 1998 |
Thiazolo[4,5-d]pyrimidines. Part II. Synthesis and anti-human cytomegalovirus activity in vitro of certain acyclonucleosides and acyclonucleotides derived from the guanine analogue 5-aminothiazolo[4,5-d]pyrimidine-2,7(3H,6H)-dione.
Topics: Antiviral Agents; Cell Line; Cytomegalovirus; Humans; Magnetic Resonance Spectroscopy; Nucleosides; Nucleotides; Pyrimidines; Pyrimidinones; Spectrophotometry, Ultraviolet; Thiazoles; Viral Plaque Assay; Virus Replication | 1998 |
Relationships between phosphatidic acid and cyclic nucleotide phosphodiesterases in activated human blood mononuclear cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Cell Division; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Immunosuppressive Agents; Leukocytes, Mononuclear; Mitogens; Muromonab-CD3; Phosphatidic Acids; Pyrimidinones; Thiazoles | 1999 |
A protein kinase C-beta-selective inhibitor ameliorates neural dysfunction in streptozotocin-induced diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Drug Therapy, Combination; Enzyme Inhibitors; Fructose; Indoles; Isoenzymes; Male; Maleimides; Motor Neurons; Neural Conduction; Protein Kinase C; Protein Kinase C beta; Pyrimidinones; Rats; Rats, Wistar; Sciatic Nerve; Sorbitol; Thiazoles | 1999 |
The role of diacylglycerol as a modulator of oxytocin-stimulated phasic contractions in myometrium from pregnant and nonpregnant rats.
Topics: Animals; Cyclohexanones; Diacylglycerol Kinase; Diglycerides; Enzyme Inhibitors; Female; Lipoprotein Lipase; Myometrium; Oxytocin; Pregnancy; Pregnancy, Animal; Pyrimidinones; Rats; Rats, Sprague-Dawley; Reference Values; Thiazoles; Uterine Contraction | 2000 |
Diacylglycerol mediates the T-cell receptor-driven Ca(2+) influx in T cells by a novel mechanism independent of protein kinase C activation.
Topics: Animals; Calcium Signaling; Cyclohexanones; Diglycerides; Enzyme Activation; Enzyme Inhibitors; In Vitro Techniques; Lipoprotein Lipase; Mice; Mice, Inbred BALB C; Naphthalenes; Nickel; Protein Kinase C; Pyrimidinones; Receptors, Antigen, T-Cell; T-Lymphocytes; Thiazoles | 2000 |
Synthesis of new [1,3,4]thiadiazolo[3,2-a]thieno[2,3-d]pyrimidinone derivatives with antiinflammatory activity.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical Phenomena; Chemistry, Physical; Edema; Lethal Dose 50; Magnetic Resonance Spectroscopy; Male; Mice; Pain Measurement; Peritonitis; Pyrimidinones; Rats; Spectrophotometry, Infrared; Stomach Ulcer; Thiazoles | 2000 |
Evidence for the involvement of diacylglycerol kinase in the activation of hypoxia-inducible transcription factor 1 by low oxygen tension.
Topics: Cell Nucleus; Diacylglycerol Kinase; Diglycerides; DNA; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; HeLa Cells; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Luciferases; Nuclear Proteins; Oxygen; Phosphatidic Acids; Phospholipids; Piperidines; Plasmids; Pyrimidinones; Quinazolines; Quinazolinones; Recombinant Proteins; Signal Transduction; Thiazoles; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection | 2001 |
PLD pathway involved in carbachol-induced Cl- secretion: possible role of TNF-alpha.
Topics: 1-Butanol; Adrenergic beta-Antagonists; Carbachol; Carcinogens; Chlorides; Cholinergic Agonists; Chromatography, Thin Layer; Diacylglycerol Kinase; Diglycerides; Dose-Response Relationship, Drug; Enzyme Inhibitors; HT29 Cells; Humans; Indoles; Intestinal Mucosa; Maleimides; Phorbol Esters; Phospholipase D; Propranolol; Protein Kinase C; Pyrimidinones; Receptors, Muscarinic; Signal Transduction; Thiazoles; Tumor Necrosis Factor-alpha | 2001 |
Efficacy of antipsychotic agents at human 5-HT(1A) receptors determined by [3H]WAY100,635 binding affinity ratios: relationship to efficacy for G-protein activation.
Topics: Animals; Antipsychotic Agents; Binding, Competitive; Chlorpromazine; CHO Cells; Clozapine; Cricetinae; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Humans; Membranes; Piperazines; Piperidines; Pyridines; Pyrimidinones; Pyrrolidines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Thiazoles; Thioridazine; Tritium | 2001 |
Synthesis and biological activity of novel pyrimidinone containing thiazolidinedione derivatives.
Topics: Animals; Blood Glucose; Cell Line; Hypoglycemic Agents; Insulin; Mice; Mice, Obese; Pyrimidinones; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Structure-Activity Relationship; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Triglycerides | 2002 |
Effect of novel modulators of protein kinase C activity upon chemotherapy-induced differentiation and apoptosis in myeloid leukemic cells.
Topics: Antineoplastic Agents; Apoptosis; CD11c Antigen; CD4 Antigens; Cell Cycle; Cell Differentiation; Diacylglycerol Kinase; Enzyme Activators; Enzyme Inhibitors; Farnesol; Flow Cytometry; Genes, fos; Genes, jun; Humans; Immunoblotting; Isoenzymes; Leukemia, Myeloid; Naphthalenes; Oncogene Protein p21(ras); Piperidines; Protein Kinase C; Pyrimidinones; Quinazolines; Quinazolinones; Sulfonamides; Thiazoles; Triazoles; Tumor Cells, Cultured | 2002 |
PMT13, a pyrimidone analogue of thiazolidinedione improves insulin resistance-associated disorders in animal models of type 2 diabetes.
Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Hypoglycemic Agents; Insulin Resistance; Liver; Mice; Mice, Obese; Pyrimidines; Pyrimidinones; Rats; Rats, Zucker; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors | 2002 |
Activation of phospholipases C and D is an early response to a cold exposure in Arabidopsis suspension cells.
Topics: Acclimatization; Arabidopsis; Calcium; Calcium Channel Blockers; Cells, Cultured; Chelating Agents; Cold Temperature; Enzyme Activation; Enzyme Inhibitors; Fatty Acids; Inositol 1,4,5-Trisphosphate; Lanthanum; Neomycin; Phosphatidic Acids; Phosphatidylinositols; Phospholipase D; Phosphorus Radioisotopes; Pyrimidinones; Signal Transduction; Thiazoles; Time Factors; Type C Phospholipases | 2002 |
Zona pellucida induces activation of phospholipase A2 during acrosomal exocytosis in guinea pig spermatozoa.
Topics: Acrosome Reaction; Animals; Arachidonic Acid; Aristolochic Acids; Calcium; Chelating Agents; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Female; Guinea Pigs; Lanthanum; Lysophosphatidylcholines; Male; Pertussis Toxin; Phospholipases A; Phospholipases A2; Pyrimidinones; Sperm Capacitation; Spermatozoa; Thiazoles; Zona Pellucida | 2003 |
Foreign body-type multinucleated giant cell formation is potently induced by alpha-tocopherol and prevented by the diacylglycerol kinase inhibitor R59022.
Topics: alpha-Tocopherol; Antioxidants; Cell Adhesion; Cell Fusion; Cells, Cultured; Diacylglycerol Kinase; Drug Synergism; Enzyme Inhibitors; Giant Cells, Foreign-Body; Humans; Interleukin-4; Macrophages; Pyrimidinones; Thiazoles; Vitamin E | 2003 |
Zeaxanthin in combination with ascorbic acid or alpha-tocopherol protects ARPE-19 cells against photosensitized peroxidation of lipids.
Topics: alpha-Tocopherol; Antioxidants; Ascorbic Acid; beta Carotene; Biological Assay; Cell Line; Cell Survival; Humans; Iron; Lipid Peroxidation; Oxidative Stress; Photochemistry; Photosensitizing Agents; Pigment Epithelium of Eye; Pyrimidinones; Singlet Oxygen; Tetrazolium Salts; Thiazoles; Xanthophylls; Zeaxanthins | 2004 |
One pot synthesis of thiazolodihydropyrimidinones and evaluation of their anticancer activity.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Pyrimidinones; Structure-Activity Relationship; Thiazoles | 2004 |
Differentiation of HL-60 cells to granulocytes involves regulation of select diacylglycerol kinases (DGKs).
Topics: Amidohydrolases; Apoptosis; CD11 Antigens; Cell Adhesion Molecules; Cell Differentiation; Diacylglycerol Kinase; Dimethyl Sulfoxide; GPI-Linked Proteins; Granulocytes; HL-60 Cells; Humans; Hydrolases; Isoenzymes; Protein Kinase Inhibitors; Pyrimidinones; Reactive Oxygen Species; RNA, Messenger; Thiazoles | 2005 |
Efficient synthesis of bicyclic oxazolino- and thiazolino[3,2-c]pyrimidine-5,7-diones and its application to the synthesis of GnRH antagonists.
Topics: Binding, Competitive; Bridged Bicyclo Compounds; Cyclization; Humans; Molecular Structure; Oxazoles; Pyrimidinones; Receptors, LHRH; Structure-Activity Relationship; Thiazoles | 2005 |
Ginger extract components suppress induction of chemokine expression in human synoviocytes.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Cells, Cultured; Chemokine CXCL10; Chemokines; Enzyme-Linked Immunosorbent Assay; Humans; Neoplasm Proteins; Plant Extracts; Pyrimidinones; Reverse Transcriptase Polymerase Chain Reaction; Synovial Membrane; Thiazoles; Tumor Necrosis Factor-alpha; Zingiber officinale | 2005 |
Simultaneous measurement of metabolic stability and metabolite identification of 7-methoxymethylthiazolo[3,2-a]pyrimidin-5-one derivatives in human liver microsomes using liquid chromatography/ion-trap mass spectrometry.
Topics: Antipsychotic Agents; Chromatography, High Pressure Liquid; Humans; Microsomes, Liver; Pyrimidinones; Spectrometry, Mass, Electrospray Ionization; Thiazoles | 2005 |
Arabidopsis AtDGK7, the smallest member of plant diacylglycerol kinases (DGKs), displays unique biochemical features and saturates at low substrate concentration: the DGK inhibitor R59022 differentially affects AtDGK2 and AtDGK7 activity in vitro and alte
Topics: Adenosine Triphosphate; Amino Acid Sequence; Arabidopsis; Bacteria; Blotting, Western; Chromatography, High Pressure Liquid; Cloning, Molecular; Cysteine; Detergents; Diacylglycerol Kinase; Diglycerides; DNA, Complementary; Dose-Response Relationship, Drug; Enzyme Inhibitors; Escherichia coli; Gene Expression Regulation, Plant; Genome, Plant; Glycerol; Hydrogen-Ion Concentration; Kinetics; Models, Genetic; Molecular Sequence Data; Multigene Family; Oleic Acids; Phosphatidic Acids; Plant Proteins; Plant Roots; Protein Structure, Tertiary; Pyrimidinones; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Amino Acid; Signal Transduction; Substrate Specificity; Thiazoles; Time Factors | 2005 |
Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening.
Topics: Animals; Cells, Cultured; Colforsin; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Drug Design; Enzyme Inhibitors; Epithelial Cells; Genistein; Humans; Iodides; Luminescent Proteins; Molecular Structure; Mutation; Pyrimidinones; Respiratory Mucosa; Thiazoles | 2005 |
Tumor cell lines resistant to ALA-mediated photodynamic therapy and possible tools to target surviving cells.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Light; Mice; Oxygen Consumption; Photochemotherapy; Photosensitizing Agents; Porphyrins; Protoporphyrins; Pyrimidinones; Tetrazolium Salts; Thiazoles | 2006 |
Convenient one pot synthesis of some novel derivatives of thiazolo[2,3-b]dihydropyrimidinone possessing 4-methylthiophenyl moiety and evaluation of their antibacterial and antifungal activities.
Topics: Anti-Bacterial Agents; Antifungal Agents; Bacteria; Chromatography, Thin Layer; Fungi; Magnetic Resonance Spectroscopy; Mass Spectrometry; Microbial Sensitivity Tests; Pyrimidinones; Spectrophotometry, Infrared; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2007 |
Calcium signaling via phospholipase C is essential for proline accumulation upon ionic but not nonionic hyperosmotic stresses in Arabidopsis.
Topics: Arabidopsis; Boron Compounds; Calcium; Calcium Signaling; Estrenes; Indoles; Inositol 1,4,5-Trisphosphate; Molecular Sequence Data; Osmotic Pressure; Proline; Pyrimidinones; Pyrrolidinones; Seedlings; Sodium Chloride; Thiazoles; Type C Phospholipases; Water | 2007 |
Nitric oxide is critical for inducing phosphatidic acid accumulation in xylanase-elicited tomato cells.
Topics: Enzyme Inhibitors; Estrenes; Gene Expression Regulation, Plant; Models, Biological; Nitric Oxide; Phosphatidic Acids; Phospholipids; Plant Physiological Phenomena; Pyrimidinones; Pyrrolidinones; Reactive Oxygen Species; Signal Transduction; Solanum lycopersicum; Thiazoles; Trichoderma; Type C Phospholipases; Xylosidases | 2007 |
A diacylglycerol kinase inhibitor, R59022, stimulates glucose transport through a MKK3/6-p38 signaling pathway in skeletal muscle cells.
Topics: Animals; Biological Transport, Active; Cells, Cultured; Diacylglycerol Kinase; Dose-Response Relationship, Drug; Glucose; MAP Kinase Kinase 3; MAP Kinase Kinase 6; MAP Kinase Signaling System; Mice; Muscle Fibers, Skeletal; p38 Mitogen-Activated Protein Kinases; Pyrimidinones; Thiazoles | 2007 |
Phospholipase C signaling involvement in macrotubule assembly and activation of the mechanism regulating protoplast volume in plasmolyzed root cells of Triticum turgidum.
Topics: Diacylglycerol Kinase; Dose-Response Relationship, Drug; Estrenes; Mannitol; Microtubules; Neomycin; Paclitaxel; Phosphoinositide Phospholipase C; Plant Roots; Protoplasts; Pyrimidinones; Pyrrolidinones; Signal Transduction; Thiazoles; Time Factors; Triticum | 2008 |
[Change of MyD88-independent signal transduction of Toll-like receptor 4 in immunological pathogenesis of Kawasaki disease].
Topics: Child; Humans; Interleukin-1; Macrophages; Nitric Oxide Synthase Type II; Pyrimidinones; Signal Transduction; Thiazoles; Toll-Like Receptor 4; Toll-Like Receptors | 2007 |
Insulin action on polyunsaturated phosphatidic acid formation in rat brain: an "in vitro" model with synaptic endings from cerebral cortex and hippocampus.
Topics: Animals; Cerebral Cortex; Chromones; Cyclosporine; Diacylglycerol Kinase; Diglycerides; Genistein; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Insulin; Insulin Antagonists; Morpholines; Okadaic Acid; Phosphatidic Acids; Phosphoprotein Phosphatases; Piperidines; Pyrimidinones; Quinazolinones; Rats; Rats, Wistar; Sodium Fluoride; Synaptosomes; Thiazoles; Vanadates | 2009 |
Fetal membranes exhibit selective leukocyte chemotaxic activity during human labor.
Topics: Cell Extracts; Cell Separation; Cells, Cultured; Chemokine CCL2; Chemokine CCL3; Chemotaxis, Leukocyte; Extraembryonic Membranes; Female; Flow Cytometry; Humans; Interleukin-8; Labor, Obstetric; Leukocytes; Pregnancy; Pyrimidinones; Thiazoles | 2009 |
Synthesis and biological activity of pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidin-4-one derivatives: in silico approach.
Topics: Computational Biology; Drug Design; Enzyme Inhibitors; Expert Systems; Gout Suppressants; Kinetics; Magnetic Resonance Spectroscopy; Models, Molecular; Pyrimidinones; Spectrophotometry, Infrared; Thiazoles; Triazoles; Xanthine Oxidase | 2010 |
Adoptive transfer of ex vivo HO-1 modified bone marrow-derived macrophages prevents liver ischemia and reperfusion injury.
Topics: Animals; Blotting, Western; Caspase 3; Cell Line; Cells, Cultured; Chemokine CCL2; E-Selectin; Heme Oxygenase-1; Interferon-gamma; Interleukin-1beta; Liver; Macrophages; Male; Mice; Mice, Inbred C57BL; Pyrimidinones; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Thiazoles; Tumor Necrosis Factor-alpha | 2010 |
Role of QuantiFERON-TB gold, interferon gamma inducible protein-10 and tuberculin skin test in active tuberculosis diagnosis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; HIV Seronegativity; Humans; Interferon-gamma; Latent Tuberculosis; Male; Middle Aged; Pyrimidinones; Reagent Kits, Diagnostic; Sensitivity and Specificity; Thiazoles; Tuberculin Test; Young Adult | 2010 |
Properties of Rikkunshi-to (TJ-43)-induced relaxation of rat gastric fundus smooth muscles.
Topics: Animals; Apamin; Drugs, Chinese Herbal; Enprostil; Gastric Fundus; Hesperidin; Membrane Potentials; Muscle Relaxation; Muscle, Smooth; Oxadiazoles; Potassium; Pyrimidinones; Quinoxalines; Rats; Thiazoles; Verapamil | 2010 |
AMPA receptors serum-dependently mediate GABAA receptor alpha1 and alpha6 subunit down-regulation in cultured mouse cerebellar granule cells.
Topics: Alanine; Animals; Cells, Cultured; Cerebellum; Coloring Agents; Culture Media, Serum-Free; Down-Regulation; GABA Agonists; GABA Antagonists; GABA-A Receptor Antagonists; GluK2 Kainate Receptor; Kainic Acid; Mice; Neurons; Protein Binding; Pyrimidinones; Quinoxalines; Receptors, AMPA; Receptors, GABA-A; Receptors, Kainic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazolium Salts; Thiazoles | 2010 |
Administered CpG oligodeoxynucleotide induces mRNA expression of CXC and CC chemokines at the intestinal mucosa and PBMCs in piglets.
Topics: Administration, Intranasal; Animals; Cell Count; Cell Movement; Chemokine CCL2; Chemokine CCL4; CpG Islands; Dendritic Cells; Immunity, Innate; Injections, Intramuscular; Intestinal Mucosa; Leukocytes, Mononuclear; Macrophages; Oligodeoxyribonucleotides; Pyrimidinones; RNA, Messenger; Swine; Thiazoles; Vaccination | 2010 |
Electron ionization-induced mass spectral study of 5-methylenecarboxy (5-methylenecarbonylalkoxy)-2-thio-(2-alkoxycarbonylalkylthio)uracils and 3-oxothiazolo-[3,2-a]-pyrimidin-6-methylenecarbonylalkoxy-5-ones.
Topics: Isomerism; Pyrimidinones; Spectrometry, Mass, Electrospray Ionization; Thiazoles; Uracil | 2010 |
Synthesis and immunological activities of novel agonists of toll-like receptor 9.
Topics: Animals; B-Lymphocytes; Cell Line; Cell Proliferation; Dendritic Cells; Female; Humans; Interferon-alpha; Lymphocyte Activation; Macaca mulatta; Mice; Mice, Inbred C57BL; Oligonucleotides; Pyrimidinones; Thiazoles; Toll-Like Receptor 9 | 2010 |
Diacylglycerol kinase alpha regulates globular adiponectin-induced reactive oxygen species.
Topics: Adiponectin; Animals; Cell Line, Tumor; Diacylglycerol Kinase; Gene Expression; Gene Knockdown Techniques; Humans; Macrophages; Mice; NADPH Oxidase 1; NADPH Oxidases; Nitric Oxide; Pyrimidinones; Reactive Oxygen Species; RNA Interference; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Thiazoles | 2011 |
Streptococcus mutans diacylglycerol kinase homologue: a potential target for anti-caries chemotherapy.
Topics: Cariostatic Agents; Dental Caries; Diacylglycerol Kinase; Enzyme Inhibitors; Genes, Bacterial; Humans; Hydrogen-Ion Concentration; Mutation; Piperidines; Pyrimidinones; Quinazolinones; Streptococcus mutans; Thiazoles | 2011 |
Diacylglycerol kinase inhibitor R59022-induced autophagy and apoptosis in the neuronal cell line NG108-15.
Topics: Animals; Apoptosis; Autophagy; Cell Line, Tumor; Diacylglycerol Kinase; Enzyme Inhibitors; Mice; Neurons; Phosphatidic Acids; Pyrimidinones; Rats; Thiazoles; TOR Serine-Threonine Kinases | 2011 |
A dual role for diacylglycerol kinase generated phosphatidic acid in autoantibody-induced neutrophil exocytosis.
Topics: Actin Cytoskeleton; Actins; Antibodies, Antineutrophil Cytoplasmic; Calcium; Cytoplasmic Granules; Diacylglycerol Kinase; Enzyme Activation; Exocytosis; Humans; Immunoglobulin Fab Fragments; Immunoglobulin G; Intracellular Space; Ionomycin; Lysophosphatidylcholines; Membrane Fusion; Neutrophils; Peroxidase; Phosphatidic Acids; Pyrimidinones; Tetraspanin 30; Thiazoles | 2011 |
A novel 3,4-dihydropyrimidin-2(1H)-one: HIV-1 replication inhibitors with improved metabolic stability.
Topics: Animals; Cell Line, Tumor; Drug Stability; HIV Reverse Transcriptase; HIV-1; Humans; Microsomes, Liver; Models, Molecular; Nevirapine; Pyrimidinones; Rats; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Thiazoles; Virus Replication | 2012 |
Isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors: SAR and pharmacokinetic evaluation.
Topics: Central Nervous System; Cyclic Nucleotide Phosphodiesterases, Type 7; Humans; Isoxazoles; Parkinson Disease; Pharmacokinetics; Phosphodiesterase Inhibitors; Pyrimidinones; Structure-Activity Relationship; Thiazoles | 2012 |
Forced mitotic entry of S-phase cells as a therapeutic strategy induced by inhibition of WEE1.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Cycle Proteins; Cell Line; Cell Line, Tumor; Checkpoint Kinase 1; Cyclins; Deoxycytidine; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Female; Gemcitabine; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, SCID; Mitosis; Nuclear Proteins; Polycomb Repressive Complex 2; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Pyrimidinones; Quinolines; S Phase; Thiazoles; Thiophenes; Transcription Factors; Tumor Burden; Tumor Suppressor Protein p53; Urea; Xenograft Model Antitumor Assays | 2012 |
Forced activation of Cdk1 via wee1 inhibition impairs homologous recombination.
Topics: CDC2 Protein Kinase; Cell Cycle Proteins; DNA Damage; Enzyme Activation; Homologous Recombination; Humans; MCF-7 Cells; Nuclear Proteins; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Pyrimidinones; Quinolines; Thiazoles | 2013 |
Diacylglycerol kinase inhibitor R59022 attenuates conjugated linoleic acid-mediated inflammation in human adipocytes.
Topics: Adipocytes; Calcium; Cells, Cultured; Chemokine CCL2; Diacylglycerol Kinase; Enzyme Inhibitors; Humans; Inflammation; Interleukin-6; Interleukin-8; Linoleic Acids, Conjugated; Pyrimidinones; Thiazoles | 2013 |
Diacylglycerol kinase θ: regulation and stability.
Topics: Animals; Cations, Divalent; Cell Line, Tumor; Central Nervous System; Diacylglycerol Kinase; Diglycerides; Enzyme Inhibitors; Enzyme Stability; Gene Expression Regulation; Hydrogen-Ion Concentration; Isoenzymes; Magnesium; Mice; Neurons; NIH 3T3 Cells; Phosphatidic Acids; Phosphatidylserines; Pyrimidinones; Signal Transduction; Thiazoles; Zinc | 2013 |
Diacylglycerol kinase α is a critical signaling node and novel therapeutic target in glioblastoma and other cancers.
Topics: Apoptosis; Brain Neoplasms; Cell Line, Tumor; Diacylglycerol Kinase; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Molecular Targeted Therapy; Piperidines; Pyrimidinones; Quinazolinones; RNA, Small Interfering; Thiazoles | 2013 |
Diacylglycerol kinase epsilon in bovine and rat photoreceptor cells. Light-dependent distribution in photoreceptor cells.
Topics: Animals; Blotting, Western; Cattle; Dark Adaptation; Diacylglycerol Kinase; Egtazic Acid; Enzyme Inhibitors; Estrenes; Fluorescent Antibody Technique, Indirect; Light; Phosphatidic Acids; Photic Stimulation; Pyrimidinones; Pyrrolidinones; Rats; Rats, Wistar; Rod Cell Outer Segment; Thiazoles | 2013 |
Evaluations of the selectivities of the diacylglycerol kinase inhibitors R59022 and R59949 among diacylglycerol kinase isozymes using a new non-radioactive assay method.
Topics: Animals; Chlorocebus aethiops; COS Cells; Diacylglycerol Kinase; Enzyme Inhibitors; High-Throughput Screening Assays; Isoenzymes; Piperidines; Pyrimidinones; Quinazolinones; Thiazoles | 2013 |
Inhibiting Tankyrases sensitizes KRAS-mutant cancer cells to MEK inhibitors via FGFR2 feedback signaling.
Topics: Acetamides; Aminopyridines; Aniline Compounds; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Drug Synergism; Erlotinib Hydrochloride; Feedback, Physiological; Female; Humans; MAP Kinase Kinase Kinases; Mice; Mice, Nude; Morpholines; Mutation; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Pyrimidinones; Quinazolines; ras Proteins; Receptor, Fibroblast Growth Factor, Type 2; Signal Transduction; Sulfonamides; Tankyrases; Thiazoles; Xenograft Model Antitumor Assays | 2014 |
Regio- and stereoselective synthesis of benzothiazolo-pyrimidinones via an NHC-catalyzed Mannich/lactamization domino reaction.
Topics: Catalysis; Imines; Lactams; Methane; Models, Molecular; Molecular Conformation; Pyrimidinones; Stereoisomerism; Substrate Specificity; Thiazoles | 2015 |
Measurement of PIP3 levels reveals an unexpected role for p110β in early adaptive responses to p110α-specific inhibitors in luminal breast cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Class I Phosphatidylinositol 3-Kinases; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Mice; Mice, Nude; Neoplasm Transplantation; ortho-Aminobenzoates; Pyrimidinones; Receptor, ErbB-2; Signal Transduction; Thiazoles | 2015 |
Breaking up is hard to do: PI3K isoforms on the rebound.
Topics: Aniline Compounds; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chromones; Class I Phosphatidylinositol 3-Kinases; Female; Humans; Neoplasms; ortho-Aminobenzoates; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; PTEN Phosphohydrolase; Pyrimidinones; Thiazoles | 2015 |
Identification and Mechanism of Action of a Novel Small-Molecule Inhibitor of Arenavirus Multiplication.
Topics: Animals; Arenaviridae Infections; Blotting, Western; Chlorocebus aethiops; HEK293 Cells; High-Throughput Screening Assays; Humans; Lymphocytic choriomeningitis virus; Plasmids; Pyrimidinones; Small Molecule Libraries; Thiazoles; Vero Cells; Virus Internalization; Virus Replication | 2015 |
Fragment-Based Discovery of Subtype-Selective Adenosine Receptor Ligands from Homology Models.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A3 Receptor Antagonists; Animals; Binding, Competitive; CHO Cells; Computer Simulation; Cricetulus; High-Throughput Screening Assays; Humans; Ligands; Molecular Docking Simulation; Pyrimidinones; Receptor, Adenosine A1; Receptor, Adenosine A3; Sequence Homology, Amino Acid; Small Molecule Libraries; Structure-Activity Relationship; Thiazoles; Thiophenes | 2015 |
Inhibition of diacylglycerol kinase α restores restimulation-induced cell death and reduces immunopathology in XLP-1.
Topics: Animals; CD8-Positive T-Lymphocytes; Cell Death; Cytokines; Diacylglycerol Kinase; Gene Silencing; Humans; Immunological Synapses; Lymphocyte Activation; Lymphocyte Count; Lymphoproliferative Disorders; Membrane Transport Proteins; Mice; Nuclear Receptor Subfamily 4, Group A, Member 1; Protein Kinase C; Protein Kinase Inhibitors; Pyrimidinones; ras Proteins; Signal Transduction; Signaling Lymphocytic Activation Molecule Associated Protein; Thiazoles | 2016 |
Addition of the p110α inhibitor BYL719 overcomes targeted therapy resistance in cells from Her2-positive-PTEN-loss breast cancer.
Topics: Aminopyridines; Animals; Antibodies; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Female; Humans; Lapatinib; Mice; Morpholines; ortho-Aminobenzoates; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; PTEN Phosphohydrolase; Pyrimidinones; Quinazolines; Receptor, ErbB-2; Thiazoles; Xenograft Model Antitumor Assays | 2016 |
Dual activities of ritanserin and R59022 as DGKα inhibitors and serotonin receptor antagonists.
Topics: Adenosine Triphosphate; Diacylglycerol Kinase; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; HEK293 Cells; HeLa Cells; Humans; Kinetics; Pyrimidinones; Ritanserin; Thiazoles | 2017 |
Survival of pancreatic cancer cells lacking KRAS function.
Topics: Animals; Antineoplastic Agents; Benzimidazoles; Carcinoma, Pancreatic Ductal; DNA Copy Number Variations; Humans; Immunoblotting; Indazoles; Mice; Morpholines; Pancreatic Neoplasms; Phenylurea Compounds; Piperidines; Proto-Oncogene Mas; Proto-Oncogene Proteins p21(ras); Purines; Pyrimidines; Pyrimidinones; Quinazolinones; Sulfonamides; Thiazoles | 2017 |
In Vitro Screening of Six Protein Kinase Inhibitors for Time-Dependent Inhibition of CYP2C8 and CYP3A4: Possible Implications with regard to Drug-Drug Interactions.
Topics: Benzamides; Benzimidazoles; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C8 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Humans; Indoles; Inhibitory Concentration 50; Microsomes, Liver; Phthalazines; Piperidines; Pyridines; Pyridones; Pyrimidinones; Quinolones; Staurosporine; Thiazoles | 2018 |
Thiazolo[3,2-a]pyrimidin-5-one derivatives as a novel class of 11β-hydroxysteroid dehydrogenase inhibitors.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Microsomes, Liver; Molecular Docking Simulation; Molecular Structure; Pyrimidinones; Structure-Activity Relationship; Thiazoles | 2018 |
Synthesis and biological screening of new thiazolo[4,5-d]pyrimidine and dithiazolo[3,2-a:5',4'-e]pyrimidinone derivatives as antimicrobial, antiquorum-sensing and antitumor agents.
Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Agents; Aspergillus fumigatus; Bacillus cereus; Candida albicans; Cell Line, Tumor; Chromobacterium; Drug Screening Assays, Antitumor; Escherichia coli; Humans; Mice; Microbial Sensitivity Tests; Molecular Structure; Pyrimidinones; Quorum Sensing; Staphylococcus aureus; Structure-Activity Relationship; Thiazoles | 2018 |
TAK-733, a Selective MEK Inhibitor, Enhances Voreloxin-induced Apoptosis in Myeloid Leukemia Cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Inducing Factor; Cell Nucleus; Cell Survival; Drug Synergism; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; MAP Kinase Kinase Kinases; Microscopy, Confocal; Naphthyridines; Protein Kinase Inhibitors; Pyridones; Pyrimidinones; Reactive Oxygen Species; Thiazoles | 2018 |
Identification of a novel DGKα inhibitor for XLP-1 therapy by virtual screening.
Topics: Cell Death; Computer Simulation; Diacylglycerol Kinase; Drug Evaluation, Preclinical; Humans; Lymphoproliferative Disorders; Piperidines; Protein Kinase Inhibitors; Pyrimidinones; Quinazolinones; Ritanserin; Thiazoles | 2019 |
A Diacylglycerol Kinase Inhibitor, R-59-022, Blocks Filovirus Internalization in Host Cells.
Topics: Animals; Chlorocebus aethiops; Diacylglycerol Kinase; Ebolavirus; Filoviridae; HEK293 Cells; Humans; Macrophages; Marburgvirus; Pinocytosis; Pyrimidinones; Receptors, Virus; Thiazoles; Vero Cells; Virus Internalization; Virus Replication | 2019 |
Convergence of Wnt and Notch signaling controls ovarian cancer cell survival.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Ovarian Epithelial; Cell Movement; Cell Proliferation; Cell Survival; Diamines; Female; Humans; Mice; Mice, Nude; Ovarian Neoplasms; Pyrimidinones; Receptors, Notch; Signal Transduction; Thiazoles; Wnt Signaling Pathway; Xenograft Model Antitumor Assays | 2019 |
Characterization of nitenpyram resistance in Nilaparvata lugens (Stål).
Topics: Animals; Carbamates; Guanidines; Hemiptera; Insect Proteins; Insecticide Resistance; Neonicotinoids; Nitro Compounds; Pyrethrins; Pyridines; Pyrimidinones; RNA Interference; Thiazoles | 2019 |
Diacylglycerol kinase and phospholipase D inhibitors alter the cellular lipidome and endosomal sorting towards the Golgi apparatus.
Topics: Cell Line, Tumor; Diacylglycerol Kinase; Diglycerides; Endocytosis; Endosomes; Enzyme Inhibitors; Golgi Apparatus; Humans; Lipidomics; Lipids; Phospholipase D; Protein Isoforms; Protein Transport; Proteolysis; Pyrimidinones; Ricin; RNA Interference; RNA, Small Interfering; Thiazoles | 2021 |
Evaluation of 5H-Thiazolo[3,2-α]pyrimidin-5-ones as Potential GluN2A PET Tracers.
Topics: Animals; Brain; Dogs; Fluorine Radioisotopes; Madin Darby Canine Kidney Cells; Male; Mice; Microsomes, Liver; Positron-Emission Tomography; Pyrimidinones; Radiopharmaceuticals; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Thiazoles; Tritium | 2020 |
Inactivation of endothelial cell phosphoinositide 3-kinase β inhibits tumor angiogenesis and tumor growth.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation; Class I Phosphatidylinositol 3-Kinases; Endothelium, Vascular; Human Umbilical Vein Endothelial Cells; Humans; Kidney Neoplasms; Melanoma, Experimental; Mice, Knockout; Microvessels; Morpholines; Neovascularization, Pathologic; Protein Kinase Inhibitors; Pyrimidinones; Sunitinib; Thiazoles; Tumor Microenvironment; Vascular Endothelial Growth Factor Receptor-2 | 2020 |
The 1-year continuation rate and discontinuation factors of vibegron and mirabegron: A retrospective comparative study in a rehabilitation hospital in Japan.
Topics: Acetanilides; Hospitals; Humans; Japan; Pyrimidinones; Pyrrolidines; Retrospective Studies; Thiazoles; Treatment Outcome | 2021 |
Radiation-Induced Autophagy in Human Pancreatic Cancer Cells is Critically Dependent on G2 Checkpoint Activation: A Mechanism of Radioresistance in Pancreatic Cancer.
Topics: Adenosine Triphosphate; Animals; Autophagy; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Female; G2 Phase Cell Cycle Checkpoints; Humans; Mice; Mice, Inbred BALB C; Pancreatic Neoplasms; Pyrazoles; Pyrimidinones; Quinolines; Radiation Tolerance; Thiazoles | 2021 |
Diacylglycerol Kinase Inhibition Reduces Airway Contraction by Negative Feedback Regulation of Gq-Signaling.
Topics: Bronchoconstriction; Cells, Cultured; Diacylglycerol Kinase; Gene Knockdown Techniques; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Muscle Contraction; Muscle, Smooth; Pyrimidinones; Signal Transduction; Thiazoles | 2021 |
Vibegron for the treatment of overactive bladder: a comprehensive update.
Topics: Acetanilides; Adrenergic beta-3 Receptor Agonists; Humans; Muscarinic Antagonists; Pyrimidinones; Pyrrolidines; Receptors, Adrenergic, beta-3; Thiazoles; Treatment Outcome; Urinary Bladder, Overactive; Urinary Incontinence | 2022 |