thiazoles has been researched along with pyrimidine in 38 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (42.11) | 18.7374 |
| 1990's | 2 (5.26) | 18.2507 |
| 2000's | 3 (7.89) | 29.6817 |
| 2010's | 15 (39.47) | 24.3611 |
| 2020's | 2 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Alspach, JD; Ingraham, LL | 1 |
| Hayashi, M; Iguchi, Y; Iizuka, K; Kajiwara, I; Kawamura, M; Miyamoto, T; Nakazawa, M; Ohyama, I; Okada, T; Taniguchi, K; Tanouchi, T | 1 |
| Fotsch, C; St Jean, DJ | 1 |
| Buxeraud, J; Comby, F; Lagorce, JF; Raby, C; Rousseau, A | 1 |
| Hansen, LF; Jacobsen, JP; Jensen, LK | 1 |
| Kumaoka, H; Tanaka, K; Tazuya, K; Yamada, K | 1 |
| DI MAGGIO, G | 1 |
| CHARETON, J; CHARONNAT, R; CHIGHIZOLA, R; EDEL, V; LECHAT, P; MOURIQUAND, G | 2 |
| INOUE, S; NAITO, T; TAKAHASHI, T | 1 |
| INOUE, S; NAITO, T | 1 |
| INOUE, S | 4 |
| HANAI, K; MACHIDA, K; SASAKI, S; UEDA, M; UNO, T | 1 |
| MOYED, HS | 1 |
| IRVIN, JL; PIANTADOSI, C; SKULASON, VG; ZAMBRANA, BF | 1 |
| FUJITA, T; IWASHIMA, A; KAWASAKI, T; NOSE, Y; UEDA, K | 1 |
| Imahori, T | 1 |
| Begley, TP; Ealick, SE; Jurgenson, CT | 1 |
| Frimurer, TM; Grimstrup, M; Högberg, T; Mathiesen, JM; Nielsen, PA; Receveur, JM; Rist, Ø | 1 |
| GOLDBERG, AA; KELLY, W | 1 |
| Chernyak, BV; Chumakov, PM; Evstafieva, AG; Khutornenko, AA; Roudko, VV; Vartapetian, AB | 1 |
| Nagaraj, A; Sanjeeva Reddy, C; Sunitha, M; Vani Devi, M | 1 |
| Karpińska, MM; Kłopotowska, D; Matysiak, J; Niewiadomy, A; Wietrzyk, J | 1 |
| Thurairatnam, S | 1 |
| Lu, S; Tao, H; Xie, J; Yang, Y; Yao, Q; Yi, P; Yu, X; Zhou, H | 1 |
| Katti, SB; Murugesan, V; Rawal, RK | 1 |
| Abbas, NS; Abdelaziz, MA; Mohareb, RM | 1 |
| Appalanaidu, K; Bhadra, MP; Dadmal, TL; Kishore, KS; Kumbhare, RM; Pushpa Valli, SN; Ramaiah, MJ; Rao, YK; Tiwari, SK | 1 |
| Hayashi, M; Kijima, Y; Tazuya-Murayama, K; Yamada, K | 1 |
| Brown, MP; Lenjisa, JL; Mekonnen, LB; Tadesse, S; Wang, S; Yu, M; Zhu, G | 1 |
| Berk, B; Biltekin, SN; Demirayak, S; Ertas, M; Sahin, Z; Yurttas, L | 1 |
| Amthor, JS; Bruner, SD; Ding, Y; Gregory, JF; Hanson, AD; Niehaus, TD; Sun, J | 1 |
| Angert, ER; Edwards, KA; Kraft, CE; Sannino, DR | 1 |
| Cherukupalli, S; Du, X; Jia, H; Liu, X; Yu, J; Zhan, P | 1 |
| Abdel-Aziz, SA; Asaad, GF; El-Koussi, NA; Gomaa, HAM; Lan, P; Taher, ES; Youssif, BGM | 1 |
5 review(s) available for thiazoles and pyrimidine
| Article | Year |
|---|---|
Mitigating heterocycle metabolism in drug discovery.
Topics: Animals; Biotransformation; Databases, Factual; Drug Discovery; Drug Interactions; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Pharmaceutical Preparations; Rats | 2012 |
[A novel deprotonative functionalization of aromatics with phosphazene base].
Topics: Benzothiazoles; Chemistry, Organic; Hydrocarbons, Aromatic; Iodides; Organic Chemistry Phenomena; Organophosphorus Compounds; Protons; Pyridazines; Pyrimidines; Thiadiazoles; Thiazoles; Zinc Compounds | 2004 |
The structural and biochemical foundations of thiamin biosynthesis.
Topics: Animals; Eukaryotic Cells; Fungi; Humans; Plants; Prokaryotic Cells; Pyrimidines; Thiamine; Thiazoles | 2009 |
Hematopoietic prostaglandin D synthase inhibitors.
Topics: Alzheimer Disease; Animals; Asthma; Dermatitis, Atopic; Drug Design; Enzyme Inhibitors; Humans; Intramolecular Oxidoreductases; Leukodystrophy, Globoid Cell; Lipocalins; Muscular Dystrophies; Niacinamide; Piperidines; Pulmonary Disease, Chronic Obstructive; Pyrazoles; Pyrimidines; Rhinitis, Allergic, Perennial; Spinal Cord Injuries; Thiazoles | 2012 |
Structure-activity relationship studies on clinically relevant HIV-1 NNRTIs.
Topics: Benzoxazines; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Piperazines; Pyrimidines; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Thiazoles; Triazines | 2012 |
33 other study(ies) available for thiazoles and pyrimidine
| Article | Year |
|---|---|
Inhibition of acetylcholinesterase by thiamine. A structure-function study.
Topics: Animals; Cholinesterase Inhibitors; Eels; Kinetics; Structure-Activity Relationship; Thiamine | 1977 |
Highly selective inhibitors of thromboxane synthetase. 2. Pyridine derivatives.
Topics: Animals; Oxidoreductases; Pyridines; Sheep; Structure-Activity Relationship; Thromboxane-A Synthase | 1981 |
Synthesis and antithyroid activity of pyridine, pyrimidine and pyrazine derivatives of thiazole-2-thiol and 2-thiazoline-2-thiol.
Topics: Animals; Antithyroid Agents; Male; Pyrazines; Pyridines; Pyrimidines; Rats; Rats, Wistar; Thiazoles; Thyrotropin; Thyroxine | 1993 |
Bis-intercalation of a homodimeric thiazole orange dye in DNA in symmetrical pyrimidine-pyrimidine-purine-purine oligonucleotides.
Topics: Base Sequence; Benzothiazoles; DNA; Fluorescent Dyes; Molecular Sequence Data; Oligonucleotides; Purines; Pyrimidines; Quinolines; Thiazoles | 1996 |
Biosynthesis of thiamin under anaerobic conditions in Saccharomyces cerevisiae.
Topics: Aerobiosis; Anaerobiosis; Carbon Radioisotopes; Formates; Glycine; Mass Spectrometry; Nitrogen Isotopes; Oxygen; Pyridoxine; Pyrimidines; Saccharomyces cerevisiae; Thiamine; Thiazoles | 2000 |
[Pharmacological studies on thiazoles. IX. Effect of associated pyrimidine and thiazole on course of avian beriberi].
Topics: Animals; Beriberi; Birds; Humans; Pyrimidines; Thiazoles | 1952 |
[Thiamine and its pyrimidine and thiazole constituents in relation to the vestibular index].
Topics: Pyrimidines; Thiamine; Thiazoles; Vestibule, Labyrinth | 1953 |
[Modification of the vestibular chronologic index of thiamine and of its pyrimidine and thiazole moieties under the influence of air].
Topics: Humans; Pyrimidines; Thiamine; Thiazoles; Vestibular Nerve; Vestibule, Labyrinth | 1953 |
Studies on pyrimidine derivatives. I. Synthesis of thiazolo (5, 4-d)-pyrimidines and related compounds. 1.
Topics: Pyrimidines; Thiazoles | 1958 |
Studies on pyrimidine derivatives. II. Synthesis of thiazolo (5, 4-d) pyrimidines and related compounds. 2.
Topics: Antihypertensive Agents; Pyrimidines; Thiazoles | 1958 |
Studies on pyrimidine derivatives. III. Synthesis of thiazolo(5, 4-d) pyrimidines and related compounds. 3.
Topics: Antihypertensive Agents; Pyrimidines; Thiazoles | 1958 |
Studies on pyrimidine derivatives. IV. Synthesis of thiazolo (5, 4-d) pyrimidines and related compounds. 4.
Topics: Pyrimidines; Thiazoles | 1958 |
Studies on pyrimidine derivatives. V. Synthesis of thiazolo (5, 4-d) pyrimidines and related compounds. 5.
Topics: Pyrimidines; Thiazoles | 1958 |
Studies on pyrimidine derivatives. VI. Synthesis of thiazolo (5, 4-d) pyrimidines and related compounds. 6.
Topics: Pyrimidines; Thiazoles | 1958 |
INFRARED SPECTRA OF SULFONAMIDE DERIVATIVES. I. PYRIDINE, THIAZOLE, AND PYRIMIDINE DERIVATIVES.
Topics: Chemistry, Pharmaceutical; Deuterium; Pyridines; Pyrimidines; Research; Spectrum Analysis; Sulfathiazoles; Sulfonamides; Thiazoles | 1963 |
INHIBITION OF THE BIOSYNTHESIS OF THE PYRIMIDINE PORTION OF THIAMINE BY ADENOSINE.
Topics: Adenosine; Enterobacter aerogenes; Histidine; Metabolism; Mutation; Nucleosides; Pharmacology; Purines; Pyrimidines; Research; Succinates; Thiamine; Thiazoles | 1964 |
SYNTHESIS OF SOME PYRIMIDINE AMINO ACIDS BY THE RHODANINE METHOD AND TESTS VS. THE EHRLICH ASCITES CARCINOMA.
Topics: Amino Acids; Animals; Ascites; Carbon Isotopes; Carcinoma; Carcinoma, Ehrlich Tumor; Chemistry, Pharmaceutical; Mice; Pharmacology; Proteins; Pyrimidines; Research; Rhodanine; Thiazoles | 1965 |
Enzymatic synthesis of thiamine. II. The thiamine synthesis from pyrimidine and thiazole phosphates and the enzymatic synthesis of pyrimidine mono- and diphosphate and thiazole monophosphate.
Topics: Biochemical Phenomena; Diphosphates; Enzymes; Phosphates; Pyrimidines; Thiamine; Thiazoles | 1961 |
Exploration of SAR features by modifications of thiazoleacetic acids as CRTH2 antagonists.
Topics: Animals; Benzhydryl Compounds; Binding Sites; Cell Line; Computer Simulation; Humans; Hydrogen Bonding; Imidazoles; Mice; Models, Molecular; Nitrogen; Pyrimidines; Rats; Receptors, Immunologic; Receptors, Prostaglandin; Structure-Activity Relationship; Thiazoles | 2010 |
Synthesis of the 2-alpha-aminoalkyl and 2-alpha-sulphanilamidoalkyl derivatives of thiazole and pyrimidine.
Topics: Antihypertensive Agents; Pyrimidines; Thiazoles | 1947 |
Pyrimidine biosynthesis links mitochondrial respiration to the p53 pathway.
Topics: Apoptosis; Cell Line, Tumor; Cell Respiration; Dihydroorotate Dehydrogenase; Electron Transport Complex III; Humans; Isoxazoles; Leflunomide; Membrane Potential, Mitochondrial; Methacrylates; Mitochondria; NAD(P)H Dehydrogenase (Quinone); Oxidoreductases Acting on CH-CH Group Donors; Potassium Cyanide; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Pyrimidines; Quinone Reductases; Reactive Oxygen Species; Signal Transduction; Thiazoles; Tumor Suppressor Protein p53; Up-Regulation | 2010 |
Synthesis and antimicrobial study of linked heterocyclics containing Pyrazole-pyrimidine-thiazolidin-4-one.
Topics: Anti-Infective Agents; Fungi; Gram-Negative Bacteria; Gram-Positive Bacteria; Heterocyclic Compounds; Magnetic Resonance Spectroscopy; Mass Spectrometry; Microbial Sensitivity Tests; Molecular Conformation; Pyrazoles; Pyrimidines; Thiazoles | 2010 |
One-pot synthesis of new (1,3-thiazolo[5,4-b]pyridin-2-yl)benzenediols and their antiproliferative activities against human cancer cell lines.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cisplatin; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Conformation; Pyrimidines; Structure-Activity Relationship; Thiazoles | 2012 |
Spectroscopic analysis of the interaction between thiazolo[2,3-b]pyrimidine analogues and bovine serum albumin.
Topics: Animals; Binding Sites; Cattle; Kinetics; Ligands; Molecular Conformation; Protein Binding; Pyrimidines; Serum Albumin, Bovine; Spectrometry, Fluorescence; Structure-Activity Relationship; Temperature; Thiazoles | 2012 |
Heterocyclic ring extension of androstenedione: synthesis and cytotoxicity of fused pyran, pyrimidine and thiazole derivatives.
Topics: Androstenedione; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fibroblasts; Hep G2 Cells; Heterocyclic Compounds; Humans; MCF-7 Cells; Molecular Conformation; Pyrans; Pyrimidines; Structure-Activity Relationship; Thiazoles | 2014 |
Synthesis and anticancer evaluation of novel triazole linked N-(pyrimidin-2-yl)benzo[d]thiazol-2-amine derivatives as inhibitors of cell survival proteins and inducers of apoptosis in MCF-7 breast cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Caspase 9; Cell Line, Tumor; Cell Survival; Cytochrome P-450 CYP1A1; G2 Phase Cell Cycle Checkpoints; Humans; M Phase Cell Cycle Checkpoints; MCF-7 Cells; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-kappa B; Pyrimidines; Structure-Activity Relationship; Thiazoles; Triazoles | 2015 |
The Biosynthesis of the Pyrimidine Moiety of Thiamin in Halobacterium salinarum.
Topics: Biosynthetic Pathways; Escherichia coli; Glycine; Halobacterium salinarum; Histidine; Purines; Pyridoxine; Pyrimidines; Ribonucleotides; Saccharomyces cerevisiae; Thiamine; Thiazoles | 2016 |
A novel series of N-(pyridin-2-yl)-4-(thiazol-5-yl)pyrimidin-2-amines as highly potent CDK4/6 inhibitors.
Topics: Amines; Binding Sites; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; G1 Phase Cell Cycle Checkpoints; GTP Phosphohydrolases; Humans; Membrane Proteins; Phosphorylation; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins B-raf; Pyridines; Pyrimidines; Retinoblastoma Protein; Structure-Activity Relationship; Thiazoles | 2017 |
Studies on non-steroidal inhibitors of aromatase enzyme; 4-(aryl/heteroaryl)-2-(pyrimidin-2-yl)thiazole derivatives.
Topics: Aromatase; Binding Sites; Catalytic Domain; Cell Proliferation; Cell Survival; Drug Design; Enzyme Inhibitors; HEK293 Cells; Humans; MCF-7 Cells; Molecular Docking Simulation; Pyrimidines; Structure-Activity Relationship; Thiazoles | 2018 |
Redesigning thiamin synthesis: Prospects and potential payoffs.
Topics: Metabolic Engineering; Metabolic Networks and Pathways; Oxygen; Plants; Pyrimidines; Synthetic Biology; Thiamine; Thiazoles | 2018 |
Thiaminase I Provides a Growth Advantage by Salvaging Precursors from Environmental Thiamine and Its Analogs in Burkholderia thailandensis.
Topics: Alkyl and Aryl Transferases; Bacterial Proteins; Burkholderia; Pyrimidines; Thiamine; Thiazoles | 2018 |
Design, diversity-oriented synthesis and biological evaluation of novel heterocycle derivatives as non-nucleoside HBV capsid protein inhibitors.
Topics: Antiviral Agents; Capsid Proteins; Dose-Response Relationship, Drug; Drug Design; Hepatitis B e Antigens; Hepatitis B virus; Microbial Sensitivity Tests; Molecular Structure; Pyrazines; Pyrazoles; Pyridines; Pyrimidines; Structure-Activity Relationship; Thiazoles; Virus Replication | 2020 |
Design, synthesis, and biological evaluation of new pyrimidine-5-carbonitrile derivatives bearing 1,3-thiazole moiety as novel anti-inflammatory EGFR inhibitors with cardiac safety profile.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cytokines; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Edema; ErbB Receptors; Heart; Molecular Structure; Protein Kinase Inhibitors; Pyrimidines; Rats; Structure-Activity Relationship; Thiazoles | 2021 |