Page last updated: 2024-08-21

thiazoles and ptc-209

thiazoles has been researched along with ptc-209 in 19 studies

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's16 (84.21)24.3611
2020's3 (15.79)2.80

Authors

AuthorsStudies
Arrowsmith, CH; Baiazitov, R; Cao, L; Davis, T; Dick, JE; Du, W; Frelin, C; Gallinger, S; Gibson, L; Iscove, NN; Kreso, A; Leung, C; Lima-Fernandes, E; Moon, YC; O'Brien, CA; Pedley, NM; Sydorenko, N; Szentgyorgyi, E; van Galen, P; Wang, Y1
Wicha, MS1
Gandour-Edwards, R; Holt, R; Rebhun, RB; Shahi, MH; Withers, SS; York, D1
Andreeff, M; Chachad, D; Ishizawa, J; Kimura, S; Kojima, K; Kornblau, SM; Maeda, A; Nishida, Y; Qiu, YH1
Berr, F; Bruckner, D; Di Fazio, P; Jakab, M; Kiesslich, T; Loeffelberger, M; Mayr, C; Neureiter, D; Ocker, M; Pichler, M; Wagner, A1
Bolomsky, A; Ludwig, H; Schlangen, K; Schreiner, W; Zojer, N1
Bhattacharya, R; Dey, A; Kumar Dhar Dwivedi, S; Mukherjee, P; Mustafi, SB; Saha, S1
Dimri, GP; Dimri, M; Kang, M1
Bharali, DJ; Glinsky, GV; Guest, I; Khedr, M; Mousa, SA; Sell, S; Srinivasan, M; Sudha, T1
Itoh, M; Ohtaka, M; Tohda, S1
Beyreis, M; Dobias, H; Gaisberger, M; Jakab, M; Kiesslich, T; Mayr, C; Neureiter, D; Pichler, M; Ritter, M1
Ai, C; Dong, F; Kang, C; Kong, Y; Sun, X; Wu, X; Xia, X; Yang, C; Zhao, Q; Zhao, X; Zhou, Y1
Damania, B; Dittmer, DP; Frye, S; Hopcraft, SE; James, LI; Pattenden, SG1
Armstrong, SA; Barbosa, K; Bohlander, SK; Chen, BR; Deshpande, A; Deshpande, AJ; Dixon, J; Dutta, S; Ghosh, A; Sun, Y; Weetall, M1
Gao, W; Guo, Y; Hacer, K; Lei, I; Li, Y; Liu, L; Tian, S; Wang, S; Wang, Z1
Alajez, NM; Aldahmash, A; Alfayez, M; Alshawakir, YA; Binhamdan, SI; Elango, R; Manikandan, M; Siyal, AA; Vishnubalaji, R1
Abete, P; Barbato, M; Bonaduce, D; Di Benedetto, G; Parisi, S; Passaro, F; Pirozzi, F; Russo, M; Russo, T; Testa, G; Tocchetti, CG1
Chen, L; Chen, X; Cheng, H; Dai, X; Gao, T; Huang, X; Li, H; Lin, M; Shao, B; Shen, C; Wang, Y; Yang, S; Yu, J; Zhao, D; Zheng, B; Zhong, X; Zhou, Q1
Al-Nadaf, S; Dickinson, PJ; Peacott-Ricardos, KS; Rebhun, RB; York, D1

Other Studies

19 other study(ies) available for thiazoles and ptc-209

ArticleYear
Self-renewal as a therapeutic target in human colorectal cancer.
    Nature medicine, 2014, Volume: 20, Issue:1

    Topics: Animals; Blotting, Western; Bromodeoxyuridine; Cell Line, Tumor; Colorectal Neoplasms; Flow Cytometry; Genetic Vectors; Heterocyclic Compounds, 2-Ring; Humans; Luciferases; Mice, Inbred NOD; Mice, SCID; Neoplasm Recurrence, Local; Neoplastic Stem Cells; Polycomb Repressive Complex 1; RNA Interference; RNA, Small Interfering; Thiazoles

2014
Targeting self-renewal, an Achilles' heel of cancer stem cells.
    Nature medicine, 2014, Volume: 20, Issue:1

    Topics: Animals; Colorectal Neoplasms; Heterocyclic Compounds, 2-Ring; Humans; Neoplasm Recurrence, Local; Neoplastic Stem Cells; Polycomb Repressive Complex 1; Thiazoles

2014
BMI1 is expressed in canine osteosarcoma and contributes to cell growth and chemotherapy resistance.
    PloS one, 2015, Volume: 10, Issue:6

    Topics: Adolescent; Animals; Antineoplastic Agents; Bone Neoplasms; Carboplatin; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Dogs; Doxorubicin; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 2-Ring; Humans; Male; Osteosarcoma; Polycomb Repressive Complex 1; Thiazoles

2015
Preclinical activity of the novel B-cell-specific Moloney murine leukemia virus integration site 1 inhibitor PTC-209 in acute myeloid leukemia: Implications for leukemia therapy.
    Cancer science, 2015, Volume: 106, Issue:12

    Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Cycle; Cell Line, Tumor; Flow Cytometry; Heterocyclic Compounds, 2-Ring; Humans; Kaplan-Meier Estimate; Leukemia, Myeloid, Acute; Polycomb Repressive Complex 1; Prognosis; Real-Time Polymerase Chain Reaction; RNA, Small Interfering; Thiazoles; Transfection

2015
The BMI1 inhibitor PTC-209 is a potential compound to halt cellular growth in biliary tract cancer cells.
    Oncotarget, 2016, Jan-05, Volume: 7, Issue:1

    Topics: Antineoplastic Agents; Biliary Tract Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cisplatin; Dose-Response Relationship, Drug; Drug Synergism; Flow Cytometry; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 2-Ring; Humans; Immunohistochemistry; Neoplastic Stem Cells; Polycomb Repressive Complex 1; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles

2016
Targeting of BMI-1 with PTC-209 shows potent anti-myeloma activity and impairs the tumour microenvironment.
    Journal of hematology & oncology, 2016, Mar-02, Volume: 9

    Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cells, Cultured; Dexamethasone; Drug Synergism; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 2-Ring; Human Umbilical Vein Endothelial Cells; Humans; Multiple Myeloma; Neovascularization, Physiologic; Oligopeptides; Osteogenesis; Polycomb Repressive Complex 1; Reverse Transcriptase Polymerase Chain Reaction; Thalidomide; Thiazoles; Tumor Microenvironment

2016
Inhibition of BMI1 induces autophagy-mediated necroptosis.
    Autophagy, 2016, Volume: 12, Issue:4

    Topics: Adenosine Triphosphate; Apoptosis; Autophagy; Caspases; Cell Line, Tumor; Heterocyclic Compounds, 2-Ring; Humans; Mitochondria; Models, Biological; Necrosis; Polycomb Repressive Complex 1; Thiazoles

2016
A miR-200c/141-BMI1 autoregulatory loop regulates oncogenic activity of BMI1 in cancer cells.
    Oncotarget, 2016, Jun-14, Volume: 7, Issue:24

    Topics: Cell Line; Cell Line, Tumor; Cellular Senescence; Gene Expression Regulation, Neoplastic; HEK293 Cells; Heterocyclic Compounds, 2-Ring; Humans; MCF-7 Cells; MicroRNAs; Neoplasms; Neoplastic Stem Cells; Polycomb Repressive Complex 1; Promoter Regions, Genetic; Protein Binding; Thiazoles

2016
Downregulation of Bmi1 in breast cancer stem cells suppresses tumor growth and proliferation.
    Oncotarget, 2017, Jun-13, Volume: 8, Issue:24

    Topics: Animals; Apoptosis; Breast Neoplasms; Cell Proliferation; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 2-Ring; Humans; Mice; Mice, Transgenic; Neoplastic Stem Cells; Polycomb Repressive Complex 1; Thiazoles; Tumor Cells, Cultured

2017
BMI1 Inhibitors Down-regulate NOTCH Signaling and Suppress Proliferation of Acute Leukemia Cells.
    Anticancer research, 2017, Volume: 37, Issue:11

    Topics: Apoptosis; Cell Proliferation; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 2-Ring; Humans; Leukemia, Myeloid, Acute; Leukemia, T-Cell; Polycomb Repressive Complex 1; Receptors, Notch; RNA, Small Interfering; Signal Transduction; Thiazoles; Tumor Cells, Cultured

2017
Miniaturization of the Clonogenic Assay Using Confluence Measurement.
    International journal of molecular sciences, 2018, Mar-03, Volume: 19, Issue:3

    Topics: Cell Line, Tumor; Cytostatic Agents; Heterocyclic Compounds, 2-Ring; Humans; Miniaturization; Thiazoles; Tumor Stem Cell Assay

2018
Targeting of BMI-1 with PTC-209 inhibits glioblastoma development.
    Cell cycle (Georgetown, Tex.), 2018, Volume: 17, Issue:10

    Topics: Animals; Brain Neoplasms; Carcinogenesis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Self Renewal; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Glioblastoma; Heterocyclic Compounds, 2-Ring; Humans; Mice, Inbred BALB C; Mice, Nude; Molecular Targeted Therapy; Neoplastic Stem Cells; Polycomb Repressive Complex 1; Promoter Regions, Genetic; RNA, Messenger; Thiazoles; Transcription, Genetic; Up-Regulation

2018
Chromatin remodeling controls Kaposi's sarcoma-associated herpesvirus reactivation from latency.
    PLoS pathogens, 2018, Volume: 14, Issue:9

    Topics: Cell Line; Chromatin Assembly and Disassembly; Depsipeptides; Epigenesis, Genetic; Genome, Viral; Herpesvirus 8, Human; Heterocyclic Compounds, 2-Ring; Histone Deacetylase Inhibitors; Host-Pathogen Interactions; Humans; Immediate-Early Proteins; Panobinostat; Polycomb Repressive Complex 1; Promoter Regions, Genetic; RNA Interference; Thiazoles; Trans-Activators; Virus Activation; Virus Latency

2018
Acute myeloid leukemia driven by the CALM-AF10 fusion gene is dependent on BMI1.
    Experimental hematology, 2019, Volume: 74

    Topics: Animals; Heterocyclic Compounds, 2-Ring; Humans; Leukemia, Myeloid, Acute; Mice; Mice, Transgenic; Neoplasms, Experimental; Oncogene Proteins, Fusion; Polycomb Repressive Complex 1; Proto-Oncogene Proteins; Thiazoles; U937 Cells; Xenograft Model Antitumor Assays

2019
Chemical suppression of specific C-C chemokine signaling pathways enhances cardiac reprogramming.
    The Journal of biological chemistry, 2019, 06-07, Volume: 294, Issue:23

    Topics: Actinin; Animals; Calcium; Cells, Cultured; Cellular Reprogramming; Chemokine CCL3; Fibroblasts; GATA4 Transcription Factor; Heterocyclic Compounds, 2-Ring; Insulin-Like Growth Factor I; MEF2 Transcription Factors; Mice; Myocytes, Cardiac; Pyrazoles; Receptors, CCR1; Signal Transduction; T-Box Domain Proteins; Thiazoles; Thiosemicarbazones; Troponin T

2019
Concurrent targeting of BMI1 and CDK4/6 abrogates tumor growth in vitro and in vivo.
    Scientific reports, 2019, 09-23, Volume: 9, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Heterocyclic Compounds, 2-Ring; Humans; Mitogen-Activated Protein Kinase 7; Piperazines; Protein Kinase Inhibitors; Pyridines; Thiazoles

2019
Bmi1 inhibitor PTC-209 promotes Chemically-induced Direct Cardiac Reprogramming of cardiac fibroblasts into cardiomyocytes.
    Scientific reports, 2020, 04-28, Volume: 10, Issue:1

    Topics: Animals; Biomarkers; Cardiac Myosins; Cellular Reprogramming; Down-Regulation; Fibroblasts; Heterocyclic Compounds, 2-Ring; Mice; Myocytes, Cardiac; Myosin Light Chains; Polycomb Repressive Complex 1; Proto-Oncogene Proteins; Signal Transduction; Thiazoles; Troponin T

2020
BMI1 promotes steroidogenesis through maintaining redox homeostasis in mouse MLTC-1 and primary Leydig cells.
    Cell cycle (Georgetown, Tex.), 2020, Volume: 19, Issue:15

    Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Cell Cycle; Cell Proliferation; Cell Survival; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p19; Heterocyclic Compounds, 2-Ring; Homeostasis; Leydig Cells; Male; Mice; Models, Biological; Oxidation-Reduction; Oxidative Stress; Polycomb Repressive Complex 1; Proto-Oncogene Proteins; Reactive Oxygen Species; Signal Transduction; Steroids; Testis; Testosterone; Thiazoles

2020
Expression and therapeutic targeting of BMI1 in canine gliomas.
    Veterinary and comparative oncology, 2022, Volume: 20, Issue:4

    Topics: Animals; Dog Diseases; Dogs; Glioma; Heterocyclic Compounds, 2-Ring; Polycomb Repressive Complex 1; Thiazoles

2022