thiazoles has been researched along with prostaglandin d2 in 131 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.76) | 18.7374 |
| 1990's | 26 (19.85) | 18.2507 |
| 2000's | 101 (77.10) | 29.6817 |
| 2010's | 3 (2.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Horiba, M; Nabe, T; Ohata, K; Watanabe-Kohno, S; Yamamura, H | 1 |
| Bito, LZ | 1 |
| Brun, RP; Chen, J; Evans, RM; Forman, BM; Spiegelman, BM; Tontonoz, P | 1 |
| Kliewer, SA; Lehmann, JM; Lenhard, JM; Morris, DC; Patel, I; Willson, TM | 1 |
| Adams, M; Chatterjee, VK; Digby, JE; Holder, JC; Lazar, MA; Montague, CT; O'Rahilly, S; Prins, JB; Sanders, L; Sewter, CP; Smith, SA | 1 |
| Jiang, C; Seed, B; Ting, AT | 1 |
| Adachi, H; Austin, S; Hirose, T; Jetten, AM; Medvedev, A; Yan, ZH | 1 |
| Franciosa, MD; Greenberg, AS; Lien, P; Souza, SC; Yamamoto, MT | 1 |
| Alvarez, JG; Evans, RM; Nagy, L; Thomazy, VA; Tontonoz, P | 1 |
| Ako, J; Eto, M; Hashimoto, M; Iijima, K; Kim, S; Liang, YQ; Ouchi, Y; Sudoh, N; Sugimoto, N; Toba, K; Yoshizumi, M | 1 |
| Libby, P; Marx, N; Murphy, C; Plutzky, J; Sukhova, G | 1 |
| Greenberg, AS; Rosenbaum, SE | 1 |
| Arakida, Y; Honda, K; Miyata, K; Ohga, K; Suwa, K; Yamada, T; Yokota, M | 1 |
| Lazar, MA; Libby, P; Marx, N; Plutzky, J; Schönbeck, U | 1 |
| Goldammer, T; Kanitz, W; Löhrke, B; Pöhland, R; Shahi, SK; Viergutz, T; Walzel, H; Wollenhaupt, K | 1 |
| Hara, M; Hashimoto, N; Hashimoto, Y; Isoo, N; Kimura, S; Maekawa, H; Satoh, H; Togo, M; Tsukamoto, K; Watanabe, T | 1 |
| Gerritsen, ME; Kowalski, J; Xin, X; Yang, S | 1 |
| Gebicke-Haerter, PJ; Kakimura, J; Kitamura, Y; Matsuoka, Y; Nomura, Y; Taniguchi, T | 1 |
| Fleck, E; Goetze, S; Gotlibowski, T; Hsueh, WA; Kawano, H; Law, RE; Xi, XP | 1 |
| Ishihara, T; Kawada, T; Matsuda, K; Matsui, T; Torii, SI; Yano, H | 1 |
| Kwon, G; Marshall, CA; McDaniel, ML; Xu, G | 1 |
| Addya, S; Boden, G; Murer, E; Sinha, D | 1 |
| Aaltonen, LA; de la Chapelle, A; Eng, C; Kum, JB; Mueller, E; Sarraf, P; Smith, WM; Spiegelman, BM; Wright, HM | 1 |
| Burris, TP; Demarest, KT; Pelton, PD; Zhou, L | 1 |
| Bailey, ST; Flanigan, A; Jiang, W; Keilbaugh, SA; Lazar, MA; Murthy, S; Rangwala, SM; Su, CG; Wen, X; Wu, GD | 1 |
| Asano, M; Chisaki, K; Imuta, H; Iwasawa, K; Morita, T; Nakajima, T; Nakamura, F; Okuda, Y; Omata, M; Yamada, N | 1 |
| Bansal, VS; Detmers, PA; Somers, EP; Vaidya, S; Wright, SD | 1 |
| Casini, A; Ceni, E; Crabb, D; Galli, A; Price, D; Salzano, R; Surrenti, C | 1 |
| Bishop-Bailey, D; Clark, RB; Estrada-Hernandez, T; Hla, T; Padula, SJ; Puddington, L | 1 |
| Cook, JA; Gilkeson, GS; Halushka, PV; Morrow, JD; Oates, JC; Reilly, CM | 1 |
| Kishimoto, T; Komoriya, K; Nakahata, T; Nonaka, T; Sugiyama, H; Tsuji, K | 1 |
| Hirasawa, N; Kushihara, M; Ohuchi, K; Takahagi, H; Takasaki, W; Takayanagi, M; Yamashita, M | 1 |
| Kalus, AM; Rubin, GL; Simpson, ER; Zhao, Y | 1 |
| Hla, T; Inoue, K; Kawahito, Y; Kohno, M; Kondo, M; Mukai, S; Sano, H; Tsubouchi, Y; Yamada, R | 1 |
| Loitsch, SM; Stein, J; Wächtershäuser, A | 1 |
| Asano, T; Fujishima, M; Iino, K; Iwase, M; Sonoki, K; Wakisaka, M; Yoshinari, M | 1 |
| Ikeda, U; Murakami, Y; Shimada, K; Shimpo, M | 1 |
| Black, PM; Brown, EM; Chattopadhyay, N; Godbole, MM; Heese, O; Singh, DP; Sinohara, T | 1 |
| Corbett, JA; Heitmeier, MR; Maggi, LB; Sadeghi, H; Scarim, AL; Weigand, C | 1 |
| Bishop-Bailey, D; Hashiramoto, A; Hla, T; Inoue, K; Kawahito, Y; Kohno, M; Kondo, M; Sano, H; Tsubouchi, Y; Yamada, R | 1 |
| Batignani, G; Bonacchi, A; Caligiuri, A; Caporale, R; Efsen, E; Gentilini, P; Laffi, G; Marra, F; Pastacaldi, S; Pinzani, M; Romanelli, RG | 1 |
| Arima, S; Igarashi, K; Ikeda, Y; Ito, S; Sugawara, A; Takeuchi, K; Taniyama, Y; Uruno, A | 1 |
| Anania, FA; Miyahara, T; Motomura, K; Rippe, R; Schrum, L; Tsukamoto, H; Willson, TM; Xiong, S; Yee, HF | 1 |
| Feinstein, DL; Heneka, MT; Klockgether, T | 1 |
| Funakoshi, Y; Hirano, K; Ichiki, T; Iino, N; Kanaide, H; Takeda, K; Takeshita, A; Tokunou, T | 1 |
| Carlson, MG; Levy, R; Nelson, DM; Sadovsky, Y; Schaiff, WT; Smith, SD | 1 |
| Banba, N; Hattori, Y; Hishinuma, A; Kakishita, H; Kasai, K; Matsumura, M; Motohashi, S; Sato, N | 1 |
| Angeli, V; Capron, M; Chinetti, G; Delerive, P; Faveeuw, C; Fontaine, J; Fougeray, S; Gosset, P; Maliszewski, C; Moser, M; Staels, B; Trottein, F | 1 |
| Cao, HJ; Kaur, K; Padilla, J; Phipps, RP; Smith, TJ | 1 |
| Chadee, K; Ford-Hutchinson, AW; Metters, KM; Wright, DH | 1 |
| Person, EC; Scanlan, TS; Taylor, RN; Waite, LL | 1 |
| Dixon, C; Hilbelink, T; Lu, L; Rovin, BH; Wilmer, WA | 1 |
| Harris, SG; Phipps, RP | 2 |
| Bond, R; Cook, J; Gilkeson, G; Guyton, K; Halushka, P; Reilly, C | 1 |
| Hla, T; Inoue , K; Kawahito, Y; Kohno, M; Sano, H; Tsubouchi, Y | 1 |
| Auwerx, J; Debril, MB; Fajas, L | 1 |
| Chen, NG; Han, X | 1 |
| Conrad, DJ; Dai, X; Luu, B; Wang, AC | 1 |
| Abe, I; Eto, K; Fujishima, M; Nakamura, Y; Ohya, Y | 1 |
| Bécuwe, P; Bianchi, A; Bordji, K; Boyault, S; Compe, E; Dauça, M; Liagre, B; Mainard, D; Netter, P; Simonin, MA; Terlain, B | 1 |
| Chlenski, A; Hattori, K; Hayashi, Y; Kita, A; Nakashiro, KI; Oyasu, R; Reddy, JK; Tamatani, T; Usuda, N | 1 |
| Arakawa, T; Fujiwara, Y; Hasuma, T; Higuchi, K; Otani, S; Takashima, T; Yano, Y | 1 |
| Ando, K; Chiba, Y; Fujita, T; Ogita, T | 1 |
| Atsumi, G; Chilton, FH; Clay, CE; Fonteh, AN; High, KP; Namen, AM; Trimboli, AJ | 1 |
| Inoue, K; Kawahito, Y; Kohno, M; Sano, H; Tsubouchi, Y; Yoshikawa, T; Yoshimura, R | 1 |
| Dulak, J; Huk, I; Jozkowicz, A; Nanobashvili, J; Nigisch, A; Prager, M; Weigel, G; Winter, B | 1 |
| Ikeda, U; Lee, RT; Ohki, R; Shimada, K; Yamamoto, K | 1 |
| Kikuta, K; Masamune, A; Sakai, Y; Satoh, A; Satoh, M; Shimosegawa, T | 1 |
| Ichiki, T; Iino, N; Takeda, K; Takeshita, A; Tokunou, T | 1 |
| Breyer, MD; Breyer, RM; Davis, L; Guan, Y; Schneider, A; Zhang, Y | 1 |
| Levine, L | 1 |
| Bécuwe, P; Bianchi, A; Bordji, K; Boyault, S; Dauça, M; Gouze, E; Netter, P; Simonin, MA; Terlain, B | 1 |
| Garmey, JC; Schoppee, PD; Veldhuis, JD | 1 |
| Berry, E; Gilmour, R; Helliwell, R; Keelan, J; Marvin, K; Mitchell, M; Nijmeijer, B; Sato, T | 1 |
| Barrera, G; Briatore, F; Dianzani, MU; Ferretti, C; Laurora, S; Pizzimenti, S | 1 |
| Masamune, A; Sakai, Y; Satoh, A; Satoh, K; Shimosegawa, T; Yoshida, M | 1 |
| Cheung, HS; Di Battista, JA; Fahmi, H; Fernandes, JC; Martel-Pelletier, J; Pelletier, JP | 1 |
| Dixon, C; Doseff, AI; Hilbelink, T; Kotur, M; Lu, L; Rovin, BH; Wilmer, WA | 1 |
| Hiraishi, H; Kojima, K; Shimada, T; Terano, A; Yoshiura, K | 1 |
| Furumatsu, T; Inoue, H; Kawai, A; Kunisada, T; Nishida, K; Takada, I; Yoshida, A | 1 |
| Boutin, JA; Nosjean, O | 1 |
| Bright, JJ; Natarajan, C | 1 |
| Hiraishi, H; Kojima, K; Mitobe, Y; Shimada, T; Terano, A; Yoshiura, K | 1 |
| Dembinska-Kiec, A; Dulak, J; Jozkowicz, A; Piatkowska, E; Placha, W | 1 |
| Dessouroux, A; Lennon, AM; Pierre, M; Ramaugé, M | 1 |
| Dransfield, I; Farrow, SN; Haslett, C; Murray, J; Rossi, AG; Ward, C | 1 |
| Feinstein, D; Grommes, C; Heneka, MT; Klockgether, T; Koenigsknecht, J; Kraus, JA; Landreth, G; Schlegel, U; Zander, T | 1 |
| Frauwirth, KA; Lazar, MA; Rangwala, SM; Thompson, CB; Wang, YL | 1 |
| Chi, KH; Chio, CC; Huang, WC; Lin, WW; Wu, HM | 1 |
| Chatterjee, PK; Cuzzocrea, S; Hattori, Y; McDonald, MC; Mota-Filipe, H; Pisano, B; Thiemermann, C; Wayman, NS | 1 |
| Miyazaki, Y; Tachibana, H; Yamada, K | 1 |
| Chicheportiche, R; Dayer, JM; Dreyer, MG; Juge-Aubry, CE; Meier, CA | 1 |
| Marx, N | 1 |
| Hiwada, K; Kitami, Y; Nakamura, M; Okura, T; Takata, Y; Yang, ZH | 1 |
| Füzesi, L; Krüger, U; Middel, P; Mössner, R; Neumann, C; Reich, K; Schinner, S; Schulz, U | 1 |
| Chan, UP; Chen, GG; Ip, PC; Lau, WY; Lee, JF; Wang, SH | 1 |
| Greenberg, AS; Mathys, JM; Rabbi, MF; Skolnik, PR | 1 |
| Georgiou, HM; Lappas, M; Permezel, M; Rice, GE | 1 |
| Hamburger, AW; Hebert, C; Nikitakis, NG; Reynolds, MA; Sauk, JJ; Siavash, H | 1 |
| Corbett, L; Knox, AJ; Nie, M; Pang, L | 1 |
| Calnek, DS; Hart, CM; Mazzella, L; Roman, J; Roser, S | 1 |
| Evers, BM; Farrow, B | 1 |
| Joe, EH; Jou, I; Park, EJ; Park, SY | 1 |
| Belvisi, MG; Bishop-Bailey, D; Mitchell, JA; Patel, HJ; Yacoub, MH | 1 |
| Brune, K; Hinz, B; Pahl, A | 1 |
| Abe, M; Furukawa, Y; Hasegawa, K; Hirai, M; Kawamura, T; Kita, T; Morimoto, T; Wada, H; Yanazume, T | 1 |
| Burghardt, R; Qin, C; Safe, S; Smith, R; Stewart, J; Wormke, M | 1 |
| Ishii, H; Kanehara, H; Miyamori, I; Oida, K; Suzuki, J; Tohda, G | 1 |
| Han, S; Huang, RP; Sidell, N; Wanichkul, T | 1 |
| Inoue, H; Miwa, Y; Miyagi, M; Morimoto, S; Sasaguri, T; Taba, Y; Takahashi-Yanaga, F | 1 |
| Ethridge, RT; Evers, BM; Hashimoto, K | 1 |
| Broaddus, RR; Copland, JA; Fischer, SM; Gottardis, MM; Houston, KD; Walker, CL | 1 |
| Abe, A; Emi, N; Kanbe, E; Kawabe, T; Saito, H; Towatari, M | 1 |
| Brüne, B; Tautenhahn, A; von Knethen, A | 1 |
| Bradbury, J; Clinton, SK; Guo, Y; Seewaldt, VL; Suster, S; Yee, LD | 1 |
| Holman, NA; May, FJ; Monteith, GR; Roberts-Thomson, SJ; Robinson, JA; Smith, SA | 1 |
| Armoni, M; Bar-Yoseph, F; Chen, H; Harel, C; Karnieli, E; Kritz, N; Quon, MJ | 1 |
| Delouis, C; Evain-Brion, D; Fournier, T; Hermouet, A; Pavan, L; Tarrade, A; Thérond, P; Titeux, M; Vidaud, M | 1 |
| Ashton, S; Cook, J; Gilkeson, G; Guyton, K; Halushka, P; Reilly, C; Tempel, G; Teti, G; Zingarelli, B | 1 |
| Burgermeister, E; Liscovitch, M; Tencer, L | 1 |
| Agarwal, N; Aoun, P; Simpkins, JW | 1 |
| LaPointe, MC; Mendez, M | 1 |
| Chao, VA; Pritts, EA; Sohn, SH; Taylor, RN; Waite, LL; Zhao, D | 1 |
| Evers, BM; Farrow, B; Hashimoto, K; Iwamura, T; O'Connor, KL | 1 |
| Azuma, Y; Date, M; Fukuchi, K; Ohura, K; Shinohara, M; Takahashi, H | 1 |
| Araki, E; Ishii, N; Itabe, H; Kawada, T; Kim-Mitsuyama, S; Matsumura, T; Motoshima, H; Murata, Y; Nishikawa, T; Senokuchi, T; Taketa, K; Takeya, M; Tsuruzoe, K; Yano, M | 1 |
| Chang, HW; Jin, M; Moon, TC; Son, JK | 1 |
| Calandra, RS; Cigorraga, SB; Frungieri, MB; Matzkin, ME; Pellizzari, EH; Rossi, SP | 1 |
| Olsson, PE; Pradhan, A | 1 |
| Lazarus, M; Oishi, Y; Saper, CB; Scammell, TE; Urade, Y; Yoshida, K | 1 |
2 review(s) available for thiazoles and prostaglandin d2
| Article | Year |
|---|---|
PPAR gamma: an essential role in metabolic control.
Topics: Adipose Tissue; Animals; Arteriosclerosis; Gene Expression; Humans; Inflammation; Insulin; Ligands; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors | 2001 |
Natural ligands of PPARgamma: are prostaglandin J(2) derivatives really playing the part?
Topics: Antiporters; Arachidonic Acid; DNA-Binding Proteins; Humans; Ligands; Linoleic Acid; Lipid Metabolism; Models, Biological; Models, Chemical; Organic Anion Transporters; Oxidation-Reduction; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Thiazoles; Transcription Factors | 2002 |
129 other study(ies) available for thiazoles and prostaglandin d2
| Article | Year |
|---|---|
MCI-826 is a potent and selective antagonist of peptide leukotrienes (p-LTs) and has characteristics distinctive from those of FPL 55712.
Topics: Acetylcholine; Animals; Bronchi; Chromones; Guinea Pigs; Humans; Leukotriene Antagonists; Leukotrienes; Muscle Contraction; Muscle, Smooth; Prostaglandin D2; Respiratory Physiological Phenomena; Respiratory System; SRS-A; Thiazoles; Trachea | 1992 |
Comparison of the ocular hypotensive efficacy of eicosanoids and related compounds.
Topics: Animals; Carbachol; Cats; Dinoprost; Dinoprostone; Epoprostenol; Female; Intraocular Pressure; Male; Prostaglandin D2; Prostaglandin Endoperoxides, Synthetic; Prostaglandins; Prostaglandins D; Prostaglandins E; Prostaglandins F; Prostaglandins F, Synthetic; Thiazoles; Thiazolidines; Timolol | 1984 |
15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma.
Topics: 3T3 Cells; Adipocytes; Animals; Base Sequence; Carrier Proteins; Cell Differentiation; Complement Factor D; DNA-Binding Proteins; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Fibroblasts; Hypoglycemic Agents; Ligands; Mice; Molecular Sequence Data; Myelin P2 Protein; Neoplasm Proteins; Nerve Tissue Proteins; Pioglitazone; Prostaglandin D2; Prostaglandins; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Recombinant Fusion Proteins; Retinoid X Receptors; RNA, Messenger; Rosiglitazone; Serine Endopeptidases; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Transcriptional Activation | 1995 |
A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation.
Topics: Adipocytes; Animals; Binding, Competitive; Cell Differentiation; Cells, Cultured; Fibroblasts; Hypoglycemic Agents; Ligands; Mice; Microbodies; Prostaglandin D2; Prostaglandins; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Rosiglitazone; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation | 1995 |
Activators of peroxisome proliferator-activated receptor gamma have depot-specific effects on human preadipocyte differentiation.
Topics: Adipocytes; Animals; Cell Differentiation; Cells, Cultured; Chromans; Humans; Mice; Microbodies; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Rosiglitazone; Stem Cells; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Troglitazone | 1997 |
PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Chromans; Cytokines; Humans; Inflammation Mediators; Leukocytes, Mononuclear; Promoter Regions, Genetic; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Necrosis Factor-alpha | 1998 |
Induction of the nuclear orphan receptor RORgamma during adipocyte differentiation of D1 and 3T3-L1 cells.
Topics: 3T3 Cells; Adipocytes; Animals; CCAAT-Enhancer-Binding Proteins; Cell Differentiation; Cell Line; Clofibrate; DNA-Binding Proteins; Fibroblasts; Humans; Lipoprotein Lipase; Mice; Nuclear Proteins; Nuclear Receptor Subfamily 1, Group D, Member 1; Nuclear Receptor Subfamily 1, Group F, Member 1; Nuclear Receptor Subfamily 1, Group F, Member 3; Prostaglandin D2; Proteins; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Receptors, Thyroid Hormone; RNA, Messenger; Stem Cells; Thiazoles; Trans-Activators; Transcription Factors; Transcriptional Activation; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Up-Regulation | 1998 |
BRL 49653 blocks the lipolytic actions of tumor necrosis factor-alpha: a potential new insulin-sensitizing mechanism for thiazolidinediones.
Topics: 3T3 Cells; Adipocytes; Animals; Carrier Proteins; Fatty Acids, Nonesterified; Glycerol; Hypoglycemic Agents; Insulin Resistance; Lipolysis; Mice; Perilipin-1; Phosphoproteins; Prostaglandin D2; Rosiglitazone; Sterol Esterase; Thiazoles; Thiazolidinediones; Tumor Necrosis Factor-alpha | 1998 |
PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL.
Topics: Alitretinoin; Animals; Arteriosclerosis; CD36 Antigens; Cell Differentiation; Dimerization; Foam Cells; HL-60 Cells; Humans; Ligands; Lipoproteins, LDL; Macrophages; Membrane Proteins; Mice; Mice, Transgenic; Monocytes; Promoter Regions, Genetic; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Receptors, Immunologic; Receptors, Lipoprotein; Receptors, Retinoic Acid; Receptors, Scavenger; Retinoid X Receptors; Rosiglitazone; Scavenger Receptors, Class B; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Tretinoin | 1998 |
Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in rat aortic smooth muscle cells.
Topics: Animals; Base Sequence; Cells, Cultured; Chromans; Gene Expression; Hypoglycemic Agents; Ligands; Molecular Sequence Data; Muscle, Smooth, Vascular; Nuclear Proteins; Oligonucleotide Probes; Polymerase Chain Reaction; Prostaglandin D2; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Troglitazone | 1998 |
Macrophages in human atheroma contain PPARgamma: differentiation-dependent peroxisomal proliferator-activated receptor gamma(PPARgamma) expression and reduction of MMP-9 activity through PPARgamma activation in mononuclear phagocytes in vitro.
Topics: Arteriosclerosis; Blotting, Northern; Blotting, Western; Cell Line; Cells, Cultured; Chromans; Collagenases; Humans; Immunoenzyme Techniques; Macrophages; Matrix Metalloproteinase 9; Monocytes; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 1998 |
The short- and long-term effects of tumor necrosis factor-alpha and BRL 49653 on peroxisome proliferator-activated receptor (PPAR)gamma2 gene expression and other adipocyte genes.
Topics: Adipocytes; Animals; Carrier Proteins; Cell Differentiation; Down-Regulation; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Gene Expression Regulation; Hypoglycemic Agents; Mice; Myelin P2 Protein; Neoplasm Proteins; Nerve Tissue Proteins; Perilipin-1; Phosphoproteins; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Sterol Esterase; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Transcription, Genetic; Tumor Necrosis Factor-alpha | 1998 |
In vitro pharmacologic profile of YM158, a new dual antagonist for LTD4 and TXA2 receptors.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Carbachol; Dinoprost; Guinea Pigs; Humans; In Vitro Techniques; Leukotriene Antagonists; Leukotriene D4; Male; Membrane Proteins; Muscle Contraction; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin D2; Receptors, Leukotriene; Receptors, Thromboxane; Tetrazoles; Thiazoles; Trachea | 1998 |
Peroxisome proliferator-activated receptor gamma activators inhibit gene expression and migration in human vascular smooth muscle cells.
Topics: Becaplermin; Cell Movement; Cells, Cultured; Chromans; Collagenases; Dinoprost; Gelatin; Gene Expression; Humans; Matrix Metalloproteinase 9; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Prostaglandin D2; Proto-Oncogene Proteins c-sis; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 1998 |
Detection and functional characterisation of the transcription factor peroxisome proliferator-activated receptor gamma in lutein cells.
Topics: Analysis of Variance; Animals; Aurintricarboxylic Acid; Cattle; Cell Cycle; Dose-Response Relationship, Drug; Female; Flow Cytometry; Granulosa Cells; Hypoglycemic Agents; Luteal Cells; Luteinizing Hormone; Microscopy, Fluorescence; Progesterone; Prostaglandin D2; Protein Isoforms; Receptors, Cytoplasmic and Nuclear; Receptors, LH; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors | 1998 |
Thiazolidinediones suppress endothelin-1 secretion from bovine vascular endothelial cells: a new possible role of PPARgamma on vascular endothelial function.
Topics: Animals; Cattle; Cells, Cultured; Chromans; Endothelin-1; Endothelium, Vascular; Hypoglycemic Agents; Insulin; Pioglitazone; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 1999 |
Peroxisome proliferator-activated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivo.
Topics: Animals; Cell Differentiation; Cell Division; Cells, Cultured; Cornea; Eicosanoids; Endothelium, Vascular; Gene Expression Regulation; Humans; Ligands; Neovascularization, Physiologic; Prostaglandin D2; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors | 1999 |
Activators of peroxisome proliferator-activated receptor-gamma (PPARgamma) inhibit inducible nitric oxide synthase expression but increase heme oxygenase-1 expression in rat glial cells.
Topics: Alitretinoin; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cells, Cultured; Dinoprostone; Enzyme Induction; Gene Expression Regulation, Enzymologic; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Interferon-gamma; Lipopolysaccharides; Neuroglia; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Prostaglandin D2; Pyrimidines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Tretinoin | 1999 |
PPAR gamma-ligands inhibit migration mediated by multiple chemoattractants in vascular smooth muscle cells.
Topics: Animals; Aorta, Thoracic; Calcium-Calmodulin-Dependent Protein Kinases; Cell Movement; Cells, Cultured; Chemotactic Factors; Chromans; Cycloheximide; Dactinomycin; Enzyme Activation; Insulin-Like Growth Factor I; Ligands; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Prostaglandin D2; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Thrombin; Transcription Factors; Troglitazone | 1999 |
Thiazolidinedione induces the adipose differentiation of fibroblast-like cells resident within bovine skeletal muscle.
Topics: Adipocytes; Adipose Tissue; Animals; Cattle; Cell Differentiation; Cells, Cultured; Fibroblasts; Ligands; Male; Muscle, Skeletal; Nuclear Proteins; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors | 1998 |
Tumor necrosis factor alpha-induced pancreatic beta-cell insulin resistance is mediated by nitric oxide and prevented by 15-deoxy-Delta12,14-prostaglandin J2 and aminoguanidine. A role for peroxisome proliferator-activated receptor gamma activation and in
Topics: Animals; Chromans; Guanidines; Hypoglycemic Agents; Insulin Resistance; Islets of Langerhans; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phosphorylation; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Ribosomal Protein S6 Kinases; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Necrosis Factor-alpha | 1999 |
15-Deoxy-delta(12,14) prostaglandin J2: a putative endogenous promoter of adipogenesis suppresses the ob gene.
Topics: Adipose Tissue; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Chromans; DNA-Binding Proteins; Dose-Response Relationship, Drug; Down-Regulation; Glucose Transporter Type 4; Humans; Hypoglycemic Agents; Indomethacin; Leptin; Monosaccharide Transport Proteins; Muscle Proteins; Nuclear Proteins; Obesity; Prostaglandin D2; Proteins; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 1999 |
Loss-of-function mutations in PPAR gamma associated with human colon cancer.
Topics: Amino Acid Substitution; Binding Sites; Chromans; Colorectal Neoplasms; Dimerization; DNA-Binding Proteins; Exons; Genes, Tumor Suppressor; Humans; Hydroxyeicosatetraenoic Acids; Ligands; Linoleic Acids; Linoleic Acids, Conjugated; Mutation; Prostaglandin D2; Protein Binding; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Response Elements; Retinoid X Receptors; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Troglitazone | 1999 |
PPARgamma activation induces the expression of the adipocyte fatty acid binding protein gene in human monocytes.
Topics: Adipocytes; Carrier Proteins; Cell Differentiation; Cell Line; Cells, Cultured; Chromans; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Fatty Acids; Gene Expression; Humans; Kinetics; Monocytes; Myelin P2 Protein; Neoplasm Proteins; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Suppressor Proteins | 1999 |
A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory response.
Topics: Animals; Caco-2 Cells; Colitis; Cytokines; DNA-Binding Proteins; Epithelium; Gene Expression; HT29 Cells; Humans; I-kappa B Proteins; Inflammation; Inflammatory Bowel Diseases; Interleukin-8; Ligands; Mice; Microbodies; NF-kappa B; NF-KappaB Inhibitor alpha; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors | 1999 |
Troglitazone and pioglitazone attenuate agonist-dependent Ca2+ mobilization and cell proliferation in vascular smooth muscle cells.
Topics: Animals; Calcium; Calcium Channels, L-Type; Cell Division; Cell Line; Chromans; Hypoglycemic Agents; Membrane Potentials; Muscle, Smooth, Vascular; Pioglitazone; Platelet-Derived Growth Factor; Prostaglandin D2; Rats; Thiazoles; Thiazolidinediones; Troglitazone; Vasopressins | 1999 |
15-Deoxy-Delta12,1412,14-prostaglandin J2 inhibits the beta2 integrin-dependent oxidative burst: involvement of a mechanism distinct from peroxisome proliferator-activated receptor gamma ligation.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; CD18 Antigens; Cell Adhesion; Cyclic AMP; Humans; Neutrophils; Prostaglandin D2; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; Receptors, Immunologic; Receptors, Prostaglandin; Respiratory Burst; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factors | 1999 |
Peroxisome proliferator-activated receptor gamma transcriptional regulation is involved in platelet-derived growth factor-induced proliferation of human hepatic stellate cells.
Topics: Cell Differentiation; Cell Division; Cells, Cultured; Gene Expression; Gene Expression Regulation; Humans; Liver; Platelet-Derived Growth Factor; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Transfection | 2000 |
The nuclear receptor PPAR gamma and immunoregulation: PPAR gamma mediates inhibition of helper T cell responses.
Topics: Adjuvants, Immunologic; Animals; Binding Sites, Antibody; CD3 Complex; Clone Cells; Female; Immune Sera; Immunosuppressive Agents; Interleukin-2; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Microbodies; Nuclear Proteins; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Spleen; T-Lymphocytes, Helper-Inducer; Thiazoles; Thiazolidinediones; Transcription Factors | 2000 |
Inhibition of mesangial cell nitric oxide in MRL/lpr mice by prostaglandin J2 and proliferator activation receptor-gamma agonists.
Topics: Animals; Cells, Cultured; Cyclooxygenase 2; Female; Glomerular Mesangium; Isoenzymes; Mice; Mice, Inbred BALB C; Mice, Inbred MRL lpr; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxisomes; Pioglitazone; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors | 2000 |
Peroxisome proliferator-activated receptors are expressed in mouse bone marrow-derived mast cells.
Topics: Animals; Bone Marrow Cells; Cells, Cultured; Chromans; Cytokines; Female; Histamine Release; Ligands; Mast Cells; Mice; Mice, Inbred BALB C; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2000 |
Inhibition by troglitazone of the antigen-induced production of leukotrienes in immunoglobulin E-sensitized RBL-2H3 cells.
Topics: Animals; Antigens; Arachidonic Acid; Calcimycin; Cell Degranulation; Cell Line; Chromans; Culture Media, Conditioned; Hydroxyurea; Hypoglycemic Agents; Immunoglobulin E; Leukotriene B4; Leukotriene C4; Leukotriene E4; Leukotrienes; Lipoxygenase Inhibitors; Male; Mast Cells; Neutrophils; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Peroxisome proliferator-activated receptor gamma ligands inhibit estrogen biosynthesis in human breast adipose tissue: possible implications for breast cancer therapy.
Topics: Adipose Tissue; Animals; Aromatase; Aromatase Inhibitors; Binding, Competitive; Breast; Breast Neoplasms; Cell Line; Cells, Cultured; Chromans; Dose-Response Relationship, Drug; Estrogens; Female; Gene Expression Regulation, Enzymologic; Humans; Ligands; Promoter Regions, Genetic; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Rosiglitazone; Stromal Cells; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Troglitazone | 2000 |
Inhibition of human lung cancer cell growth by the peroxisome proliferator-activated receptor-gamma agonists through induction of apoptosis.
Topics: Apoptosis; Base Sequence; Cell Division; Chromans; DNA Primers; Humans; Lung Neoplasms; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2000 |
PPAR-gamma is selectively upregulated in Caco-2 cells by butyrate.
Topics: Alkaline Phosphatase; Blotting, Western; Butyrates; Caco-2 Cells; Cell Differentiation; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Pentanoic Acids; Propionates; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substrate Specificity; Thiazoles; Thiazolidinediones; Transcription Factors; Up-Regulation | 2000 |
Peroxisome proliferator-activated receptor gamma1 (PPARgamma1) expresses in rat mesangial cells and PPARgamma agonists modulate its differentiation.
Topics: Animals; Blotting, Western; Cell Differentiation; Cell Division; Cells, Cultured; Chromans; Dose-Response Relationship, Drug; Gene Expression; Glomerular Mesangium; Nuclear Proteins; Oligonucleotides; Prostaglandin D2; Protein Binding; Protein Isoforms; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Response Elements; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2000 |
Peroxisome proliferator-activated receptor-gamma ligands inhibit nitric oxide synthesis in vascular smooth muscle cells.
Topics: Animals; Cells, Cultured; Chromans; Humans; Interleukin-1; Ligands; Muscle, Smooth, Vascular; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2000 |
Expression of peroxisome proliferator-activated receptors (PPARS) in human astrocytic cells: PPARgamma agonists as inducers of apoptosis.
Topics: Apoptosis; Astrocytes; Caspase 3; Caspases; Cell Survival; DNA Fragmentation; Gene Expression; Humans; Hypoglycemic Agents; Peroxisomes; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors | 2000 |
Anti-inflammatory actions of 15-deoxy-delta 12,14-prostaglandin J2 and troglitazone: evidence for heat shock-dependent and -independent inhibition of cytokine-induced inducible nitric oxide synthase expression.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Chromans; Cytokines; Hot Temperature; Interferon-gamma; Interleukin-1; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice; Mice, Inbred Strains; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Shock; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
15-deoxy-delta(12,14)-PGJ(2) induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats.
Topics: Animals; Apoptosis; Arthritis; Arthritis, Experimental; Arthritis, Rheumatoid; Cells, Cultured; Chromans; Female; Humans; Ligands; Osteoarthritis; Prostaglandin D2; Rats; Rats, Inbred Lew; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Synovial Membrane; Thiazoles; Thiazolidinediones; Tissue Distribution; Transcription Factors; Troglitazone | 2000 |
Ligands of peroxisome proliferator-activated receptor gamma modulate profibrogenic and proinflammatory actions in hepatic stellate cells.
Topics: Antineoplastic Agents; Biological Transport; Cell Division; Cell Movement; Cell Survival; Cells, Cultured; Chemokine CCL2; Chromans; Cytotoxins; Gene Expression; Hepatitis; Humans; Interleukin-1; Ligands; Liver; Liver Cirrhosis; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet-Derived Growth Factor; Prostaglandin D2; Proto-Oncogenes; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factor AP-1; Transcription Factors; Troglitazone; Tyrosine; Wound Healing | 2000 |
Suppression of rat thromboxane synthase gene transcription by peroxisome proliferator-activated receptor gamma in macrophages via an interaction with NRF2.
Topics: Animals; Base Sequence; Binding Sites; Chromans; Cloning, Molecular; DNA-Binding Proteins; Gene Expression Regulation, Enzymologic; Hypoglycemic Agents; Leucine Zippers; Macrophages; Molecular Sequence Data; NF-E2-Related Factor 2; Prostaglandin D2; Rats; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Thiazoles; Thiazolidinediones; Thromboxane-A Synthase; Trans-Activators; Transcription Factors; Transcription, Genetic; Troglitazone | 2000 |
Peroxisome proliferator-activated receptors and hepatic stellate cell activation.
Topics: Animals; Cell Size; Cell Survival; Cells, Cultured; Collagen; DNA; Gene Expression Regulation; Liver; Liver Cirrhosis, Biliary; Liver Cirrhosis, Experimental; Male; Promoter Regions, Genetic; Prostaglandin D2; Protein Binding; Protein Isoforms; Pyrimidines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Tumor Necrosis Factor-alpha | 2000 |
Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Death; Cerebellum; Chromans; Cyclooxygenase Inhibitors; Down-Regulation; Ibuprofen; Immunohistochemistry; In Situ Nick-End Labeling; Interferon-gamma; Ligands; Lipopolysaccharides; Male; Microinjections; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrobenzenes; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Sulfonamides; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2000 |
Peroxisome proliferator-activated receptor gamma activators downregulate angiotensin II type 1 receptor in vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Calcium; Cells, Cultured; Chromans; Down-Regulation; Gene Expression Regulation; Muscle, Smooth, Vascular; Promoter Regions, Genetic; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Receptors, Cytoplasmic and Nuclear; RNA Stability; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2000 |
Peroxisome proliferator-activated receptor-gamma modulates differentiation of human trophoblast in a ligand-specific manner.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Differentiation; Cells, Cultured; Chorionic Gonadotropin; Chromans; Densitometry; Fluorescent Antibody Technique; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Ligands; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Transfection; Troglitazone; Trophoblasts | 2000 |
15-Deoxy-Delta(12,14)-prostaglandin J(2) facilitates thyroglobulin production by cultured human thyrocytes.
Topics: Anticholesteremic Agents; Arsenites; Bucladesine; Cells, Cultured; Chromans; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fetal Proteins; Gene Expression Regulation, Enzymologic; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Hypoglycemic Agents; Ligands; Membrane Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pioglitazone; Prostaglandin D2; Pyrimidines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Sodium Compounds; Thiazoles; Thiazolidinediones; Thyroglobulin; Thyroid Gland; Thyrotropin; Transcription Factors; Troglitazone | 2000 |
Peroxisome proliferator-activated receptor gamma activators inhibit interleukin-12 production in murine dendritic cells.
Topics: Animals; Antigens, CD; CD40 Antigens; Cell Differentiation; Dendritic Cells; Dimethyl Sulfoxide; Interferon-gamma; Interleukin-12; Interleukins; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; T-Lymphocytes; Thiazoles; Thiazolidinediones; Transcription Factors | 2000 |
Peroxisome proliferator activator receptor-gamma agonists and 15-deoxy-Delta(12,14)(12,14)-PGJ(2) induce apoptosis in normal and malignant B-lineage cells.
Topics: Animals; Apoptosis; B-Lymphocytes; Cell Lineage; Cells, Cultured; Chromans; Dinoprost; Hypoglycemic Agents; Lymphoma, B-Cell; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2000 |
The human prostanoid DP receptor stimulates mucin secretion in LS174T cells.
Topics: Benzoates; Binding, Competitive; Cell Membrane; Colon; Cyclic AMP; Dinoprostone; Dose-Response Relationship, Drug; Humans; Hydantoins; In Situ Hybridization; Mucins; Prostaglandin D2; Radioligand Assay; Receptors, Immunologic; Receptors, Prostaglandin; RNA, Messenger; Thiazoles; Thiazolidines; Transcription, Genetic; Tritium; Tumor Cells, Cultured | 2000 |
Albumin regulates induction of peroxisome proliferator-activated receptor-gamma (PPARgamma) by 15-deoxy-delta(12-14)-prostaglandin J(2) in vitro and may be an important regulator of PPARgamma function in vivo.
Topics: Hot Temperature; Immunologic Factors; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Serum Albumin; Thiazoles; Thiazolidinediones; Transcription Factors; Tumor Cells, Cultured | 2001 |
A cyclopentenone prostaglandin activates mesangial MAP kinase independently of PPARgamma.
Topics: Cells, Cultured; Cyclopentanes; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glomerular Mesangium; Humans; Hypoglycemic Agents; Immunologic Factors; JNK Mitogen-Activated Protein Kinases; Ligands; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Prostaglandin D2; Prostaglandins; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors | 2001 |
The nuclear receptor PPAR gamma is expressed by mouse T lymphocytes and PPAR gamma agonists induce apoptosis.
Topics: Animals; Antigen Presentation; Apoptosis; Cell Division; Cell Survival; Cells, Cultured; Chromans; Flow Cytometry; Immunohistochemistry; In Situ Nick-End Labeling; Ionomycin; Ligands; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Transgenic; Prostaglandin D2; Pyrimidines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Specific Pathogen-Free Organisms; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2001 |
Differential effects of 15-deoxy-delta(12,14)-prostaglandin J2 and a peroxisome proliferator-activated receptor gamma agonist on macrophage activation.
Topics: Animals; Cyclopentanes; DNA-Binding Proteins; Enzyme Activation; Epoprostenol; I-kappa B Proteins; Lipopolysaccharides; Macrophage Activation; Macrophages, Peritoneal; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; NF-KappaB Inhibitor alpha; Nitric Oxide; Phosphorylation; Prostaglandin D2; Protein Processing, Post-Translational; Rats; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidinediones; Thromboxane B2; Transcription Factors; Tumor Necrosis Factor-alpha | 2001 |
Feedback control of the arachidonate cascade in rheumatoid synoviocytes by 15-deoxy-Delta(12,14)-prostaglandin J2.
Topics: Arachidonic Acid; Arthritis, Rheumatoid; Chromans; Cyclooxygenase 2; Cysteine; Dinoprostone; Feedback; Humans; Isoenzymes; Leukotriene Antagonists; Leukotriene B4; Leukotrienes; Membrane Proteins; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Receptors, Cytoplasmic and Nuclear; Synovial Membrane; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2001 |
Dual function of troglitazone in ICAM-1 gene expression in human vascular endothelium.
Topics: Base Sequence; Cell Line, Transformed; Chromans; DNA Primers; Endothelium, Vascular; Enzyme Activation; Gene Expression; Genes, fos; Humans; Hypoglycemic Agents; Intercellular Adhesion Molecule-1; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; NF-kappa B; Prostaglandin D2; Proto-Oncogene Proteins c-fos; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factor AP-1; Transcription Factors; Troglitazone; Tumor Necrosis Factor-alpha | 2001 |
Peroxisome proliferator-activated receptor-gamma regulates airway epithelial cell activation.
Topics: Adjuvants, Immunologic; Cytokines; Down-Regulation; Humans; Inflammation Mediators; Interleukin-4; Interleukin-8; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Respiratory Mucosa; RNA, Messenger; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factors | 2001 |
Comparative actions of insulin sensitizers on ion channels in vascular smooth muscle.
Topics: Analysis of Variance; Animals; Barium; Calcium; Chromans; Dose-Response Relationship, Drug; Electric Stimulation; Female; Guinea Pigs; Humans; Insulin Resistance; Ion Channels; Isoxazoles; Membrane Potentials; Muscle, Smooth, Vascular; Pioglitazone; Potassium Channels; Prostaglandin D2; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
15-Deoxy-delta12,14-PGJ2, but not troglitazone, modulates IL-1beta effects in human chondrocytes by inhibiting NF-kappaB and AP-1 activation pathways.
Topics: Active Transport, Cell Nucleus; Blotting, Western; Cell Nucleus; Cells, Cultured; Chondrocytes; Chromans; Cyclooxygenase 2; DNA; Enzyme Induction; Gene Expression Regulation; Humans; Interleukin-1; Isoenzymes; Ligands; Membrane Proteins; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Protein Binding; Proteoglycans; Proto-Oncogene Proteins c-jun; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factor AP-1; Transcription Factors; Troglitazone | 2001 |
Role of peroxisome proliferator-activated receptor gamma and its ligands in non-neoplastic and neoplastic human urothelial cells.
Topics: Aged; Blotting, Western; Cell Division; Cell Line; Chromans; Dose-Response Relationship, Drug; Humans; Immunologic Factors; Ligands; Male; Pioglitazone; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Transfection; Troglitazone; Tumor Cells, Cultured; Urinary Bladder Neoplasms; Urothelium | 2001 |
PPAR-gamma ligands inhibit growth of human esophageal adenocarcinoma cells through induction of apoptosis, cell cycle arrest and reduction of ornithine decarboxylase activity.
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Squamous Cell; Cell Cycle; Cell Division; Chromans; DNA Primers; Esophageal Neoplasms; Flow Cytometry; Humans; Immunologic Factors; Ligands; Ornithine Decarboxylase; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazolium Salts; Thiazoles; Thiazolidinediones; Thymidine; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2001 |
PPARgamma ligands inhibit TNF-alpha-induced LOX-1 expression in cultured endothelial cells.
Topics: Animals; Arteriosclerosis; Cattle; Cells, Cultured; Chromans; Drug Antagonism; Endothelium; Immunohistochemistry; Pioglitazone; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Receptors, LDL; Receptors, Oxidized LDL; RNA, Messenger; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Troglitazone; Tumor Necrosis Factor-alpha | 2001 |
Magnitude of peroxisome proliferator-activated receptor-gamma activation is associated with important and seemingly opposite biological responses in breast cancer cells.
Topics: Apoptosis; Breast Neoplasms; Cell Cycle; Cell Differentiation; Cell Division; Chromans; Female; Humans; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Troglitazone; Tumor Cells, Cultured | 2001 |
Expression of peroxisome proliferator-activated receptor gamma in renal cell carcinoma and growth inhibition by its agonists.
Topics: Antineoplastic Agents; Blotting, Western; Carcinoma, Renal Cell; Cell Division; Chromans; Coloring Agents; Dose-Response Relationship, Drug; Humans; Hypoglycemic Agents; Immunohistochemistry; Immunologic Factors; Kidney Neoplasms; Ligands; Pioglitazone; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazolium Salts; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Cells, Cultured; Up-Regulation | 2001 |
Prostaglandin-J2 induces synthesis of interleukin-8 by endothelial cells in a PPAR-gamma-independent manner.
Topics: Cell Line; Cell Survival; Electrophoretic Mobility Shift Assay; Endothelium, Vascular; Humans; Interleukin-8; Ligands; NF-kappa B; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Transfection; Up-Regulation | 2001 |
Peroxisome proliferator-activated receptor gamma activators inhibit cardiac hypertrophy in cardiac myocytes.
Topics: Angiotensin II; Animals; Animals, Newborn; Biological Transport; Cardiomegaly; Cells, Cultured; Chromans; Heart; Leucine; Myocardium; Natriuretic Peptide, Brain; NF-kappa B; Phenylephrine; Prostaglandin D2; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Stress, Mechanical; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2001 |
Ligands of peroxisome proliferator-activated receptor-gamma block activation of pancreatic stellate cells.
Topics: Actins; Animals; Cells, Cultured; Chemokine CCL2; Chromans; Collagen Type I; G1 Phase; Ligands; NF-kappa B; Pancreas; Prostaglandin D2; Rats; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
15-Deoxy-delta 12,14-prostaglandin J2 and thiazolidinediones activate the MEK/ERK pathway through phosphatidylinositol 3-kinase in vascular smooth muscle cells.
Topics: Androstadienes; Animals; Cells, Cultured; Chromans; Enzyme Activation; Enzyme Inhibitors; Immunologic Factors; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pioglitazone; Prostaglandin D2; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Thymidine; Transcription Factors; Troglitazone; Wortmannin | 2001 |
Peroxisome proliferator-activated receptor-gamma activity is associated with renal microvasculature.
Topics: Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins; Cell Division; Cell Survival; Cells, Cultured; Chromans; Cloning, Molecular; Endothelium, Vascular; Fatty Acid-Binding Proteins; Glomerular Mesangium; Hypoglycemic Agents; Kidney Glomerulus; Molecular Sequence Data; Neoplasm Proteins; Prostaglandin D2; Rabbits; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Troglitazone | 2001 |
Stimulated release of arachidonic acid by agonists of the peroxisome proliferator-activated receptor and retinoic acid receptors.
Topics: Alitretinoin; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Celecoxib; Cell Line; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Drug Synergism; Indomethacin; Kinetics; Liver; Prostaglandin D2; Prostaglandins A; Pyrazoles; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Sulfonamides; Thiazoles; Thiazolidinediones; Transcription Factors; Tretinoin | 2001 |
PPAR-gamma ligands modulate effects of LPS in stimulated rat synovial fibroblasts.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chromans; Cyclooxygenase 2; Fibroblasts; Gene Expression; Interleukin-1; Isoenzymes; Ligands; Lipopolysaccharides; Male; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Synovial Membrane; Thiazoles; Thiazolidinediones; Transcription Factor AP-1; Transcription Factors; Troglitazone; Tumor Necrosis Factor-alpha | 2002 |
Putative activation of the peroxisome proliferator-activated receptor gamma impairs androgen and enhances progesterone biosynthesis in primary cultures of porcine theca cells.
Topics: Androgens; Animals; Blotting, Western; Cells, Cultured; Chromans; DNA; Female; Fluorescent Dyes; Hypoglycemic Agents; Insulin; Luteinizing Hormone; Organic Chemicals; Ovary; Progesterone; Prostaglandin D2; Radioimmunoassay; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Steroid 17-alpha-Hydroxylase; Swine; Theca Cells; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
15-deoxy-delta12,14-prostaglandin J2-induced apoptosis in amnion-like WISH cells.
Topics: Amino Acid Chloromethyl Ketones; Amnion; Apoptosis; Caspase Inhibitors; Caspases; Cell Survival; Cells, Cultured; Cysteine Proteinase Inhibitors; Enzyme Activation; Humans; Hypoglycemic Agents; Immunologic Factors; Ligands; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors | 2001 |
Synergistic effect of 4-hydroxynonenal and PPAR ligands in controlling human leukemic cell growth and differentiation.
Topics: Aldehydes; Cell Differentiation; Cell Division; Chromans; Clofibrate; Clofibric Acid; Drug Synergism; Fibric Acids; HL-60 Cells; Humans; Ligands; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Troglitazone; U937 Cells | 2002 |
Prostaglandin D(2), its metabolite 15-d-PGJ(2), and peroxisome proliferator activated receptor-gamma agonists induce apoptosis in transformed, but not normal, human T lineage cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Division; Cell Line, Transformed; Cell Survival; Cells, Cultured; Chromans; Humans; Hydantoins; In Situ Nick-End Labeling; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
Ligands of peroxisome proliferator-activated receptor-gamma induce apoptosis in AR42J cells.
Topics: Amino Acid Chloromethyl Ketones; Animals; Annexin A5; Antineoplastic Agents; Apoptosis; Caspase Inhibitors; Cell Line; Chromans; Clusterin; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Gene Expression; Glycoproteins; I-kappa B Proteins; Immunologic Factors; Ligands; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; Molecular Chaperones; NF-KappaB Inhibitor alpha; Oligopeptides; Pancreas; Pancreatitis-Associated Proteins; Prostaglandin D2; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
Peroxisome proliferator-activated receptor gamma activators inhibit MMP-1 production in human synovial fibroblasts likely by reducing the binding of the activator protein 1.
Topics: Aged; Blotting, Northern; Cells, Cultured; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Gene Expression; Humans; Interleukin-1; Matrix Metalloproteinase 1; Promoter Regions, Genetic; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Rosiglitazone; Synovial Membrane; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic | 2002 |
15-Deoxy-Delta12,14-prostaglandin J2 regulates mesangial cell proliferation and death.
Topics: 1-Phosphatidylinositol 4-Kinase; Cell Death; Cell Division; Cells, Cultured; Chromans; Chromones; Enzyme Inhibitors; Glomerular Mesangium; Humans; Morpholines; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
Characteristics of the peroxisome proliferator activated receptor gamma (PPARgamma) ligand induced apoptosis in colon cancer cells.
Topics: Apoptosis; Cell Division; Cell Survival; Chromans; Colonic Neoplasms; DNA, Complementary; DNA, Neoplasm; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Ligands; Neoplasm Proteins; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
Inhibition of human chondrosarcoma cell growth via apoptosis by peroxisome proliferator-activated receptor-gamma.
Topics: Apoptosis; Cell Cycle; Cell Division; Cell Survival; Chondrosarcoma; Flow Cytometry; Humans; Male; Microscopy, Electron; Pioglitazone; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Tumor Cells, Cultured | 2002 |
Peroxisome proliferator-activated receptor-gamma agonists inhibit experimental allergic encephalomyelitis by blocking IL-12 production, IL-12 signaling and Th1 differentiation.
Topics: Animals; Cell Differentiation; Cells, Cultured; DNA-Binding Proteins; Dose-Response Relationship, Drug; Encephalomyelitis, Autoimmune, Experimental; Immunologic Factors; Interleukin-12; Janus Kinase 2; Kinetics; Lymphocyte Activation; Macrophages; Mice; Microglia; Myelin Basic Protein; Prostaglandin D2; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Spinal Cord; Th1 Cells; Thiazoles; Thiazolidinediones; Transcription Factors | 2002 |
Effect of PPARgamma ligands on the viability of gastric epithelial cells.
Topics: Animals; Apoptosis; Blotting, Western; Cell Survival; Chromans; DNA, Complementary; Dose-Response Relationship, Drug; Epithelial Cells; Gastric Mucosa; Gene Expression Regulation; Humans; Immunologic Factors; Ligands; Microscopy, Phase-Contrast; Prostaglandin D2; Rats; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2002 |
Ligands of peroxisome proliferator-activated receptor-gamma increase the generation of vascular endothelial growth factor in vascular smooth muscle cells and in macrophages.
Topics: Animals; Antineoplastic Agents; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Growth Factors; Endothelium, Vascular; Hypoglycemic Agents; Interleukin-1; Ligands; Lipopolysaccharides; Lymphokines; Macrophages; Mice; Muscle, Smooth; Promoter Regions, Genetic; Prostaglandin D2; Rats; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Transfection; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
MAP kinase cascades are activated in astrocytes and preadipocytes by 15-deoxy-Delta(12-14)-prostaglandin J(2) and the thiazolidinedione ciglitazone through peroxisome proliferator activator receptor gamma-independent mechanisms involving reactive oxygenat
Topics: Adipocytes; Animals; Astrocytes; Cells, Cultured; Enzyme Activation; MAP Kinase Signaling System; Prostaglandin D2; Rats; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors | 2002 |
Prostaglandin D2 and its metabolites induce caspase-dependent granulocyte apoptosis that is mediated via inhibition of I kappa B alpha degradation using a peroxisome proliferator-activated receptor-gamma-independent mechanism.
Topics: Apoptosis; Binding Sites; Caspases; Cell Death; Cells, Cultured; Dinoprost; DNA-Binding Proteins; Enzyme Activation; Eosinophils; Granulocytes; Humans; Hydrolysis; I-kappa B Proteins; Neutrophils; NF-kappa B; NF-KappaB Inhibitor alpha; Peroxisomes; Prostaglandin D2; Protein Biosynthesis; Receptors, Cytoplasmic and Nuclear; Receptors, Immunologic; Receptors, Prostaglandin; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors | 2002 |
Induction of apoptosis in human and rat glioma by agonists of the nuclear receptor PPARgamma.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Protein; Cadherins; Carrier Proteins; Cell Division; Cell Survival; DNA Fragmentation; Drug Evaluation, Preclinical; Glioma; Humans; Nuclear Proteins; Oligonucleotides, Antisense; Prostaglandin D2; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Rats; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Tumor Cells, Cultured | 2002 |
Thiazolidinedione activation of peroxisome proliferator-activated receptor gamma can enhance mitochondrial potential and promote cell survival.
Topics: Animals; Cell Death; Cell Survival; Cells, Cultured; Humans; Hypoglycemic Agents; Interleukin-3; Lymphocyte Activation; Membrane Potentials; Mice; Mice, Inbred C57BL; Mitochondria; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Rosiglitazone; T-Lymphocytes; Thiazoles; Thiazolidinediones; Transcription Factors; Transfection; Up-Regulation | 2002 |
Superoxide anion-dependent Raf/MEK/ERK activation by peroxisome proliferator activated receptor gamma agonists 15-deoxy-delta(12,14)-prostaglandin J(2), ciglitazone, and GW1929.
Topics: Animals; Benzophenones; Cell Line; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Peroxisomes; Phosphatidylinositol 3-Kinases; Phosphorylation; Prostaglandin D2; Protein Kinase C; Proto-Oncogene Proteins c-raf; ras Proteins; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; Superoxides; Thiazoles; Thiazolidinediones; Transcription Factors; Tyrosine | 2002 |
Ligands of the peroxisome proliferator-activated receptors (PPAR-gamma and PPAR-alpha) reduce myocardial infarct size.
Topics: Adult; Animals; Cardiotonic Agents; Cell Adhesion Molecules; Cell Line; Cells, Cultured; Chemokine CCL2; Clofibrate; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Ligands; Male; Membrane Proteins; Myocardial Infarction; Myocardial Reperfusion Injury; Pioglitazone; Prostaglandin D2; Prostaglandins A; Protein Isoforms; Pyrimidines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors | 2002 |
Inhibitory effect of peroxisome proliferator-activated receptor-gamma ligands on the expression of IgE heavy chain germline transcripts in the human B cell line DND39.
Topics: B-Lymphocytes; Cell Line; Germ Cells; Humans; Immunoglobulin E; Immunoglobulin Heavy Chains; Interleukin-4; Ligands; Phosphorylation; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; STAT6 Transcription Factor; Thiazoles; Thiazolidinediones; Trans-Activators; Transcription Factors | 2002 |
Regulation of the interleukin-1 receptor antagonist in THP-1 cells by ligands of the peroxisome proliferator-activated receptor gamma.
Topics: Antineoplastic Agents; Cell Differentiation; Cell Line; Cell Separation; Enzyme Inhibitors; Fibrinolytic Agents; Flow Cytometry; Humans; Inflammation; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Interleukin-6; Ligands; Monocytes; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Sialoglycoproteins; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Tretinoin; Tumor Necrosis Factor-alpha; Up-Regulation; Vitamin D | 2002 |
PPARgamma and vascular inflammation: adding another piece to the puzzle.
Topics: Animals; CCAAT-Enhancer-Binding Protein-delta; CCAAT-Enhancer-Binding Proteins; Cells, Cultured; Chromans; DNA-Binding Proteins; Gene Expression Regulation; Inflammation; Luciferases; Muscle, Smooth, Vascular; NF-kappa B; Phosphorylation; Prostaglandin D2; Protein Binding; Rats; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; STAT3 Transcription Factor; Thiazoles; Thiazolidinediones; Trans-Activators; Transcription Factors; Troglitazone | 2002 |
Vascular inflammation is negatively autoregulated by interaction between CCAAT/enhancer-binding protein-delta and peroxisome proliferator-activated receptor-gamma.
Topics: Animals; Carotid Arteries; CCAAT-Enhancer-Binding Protein-delta; CCAAT-Enhancer-Binding Proteins; Cells, Cultured; Chromans; DNA-Binding Proteins; Gene Expression Regulation; Inflammation; Interleukin-6; Luciferases; Male; Muscle, Smooth, Vascular; NF-kappa B; Phosphorylation; Prostaglandin D2; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; STAT3 Transcription Factor; Thiazoles; Thiazolidinediones; Trans-Activators; Transcription Factors; Transcription, Genetic; Troglitazone | 2002 |
Agonists of peroxisome proliferator-activated receptor gamma inhibit cell growth in malignant melanoma.
Topics: Antineoplastic Agents; Apoptosis; Cell Division; Chromans; Dose-Response Relationship, Drug; Fibrinolytic Agents; Gene Expression Regulation, Neoplastic; Humans; Immunologic Factors; Melanoma; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Skin Neoplasms; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2002 |
Apoptosis induced by activation of peroxisome-proliferator activated receptor-gamma is associated with Bcl-2 and NF-kappaB in human colon cancer.
Topics: Apoptosis; Cell Division; Cell Survival; Colon; Colonic Neoplasms; DNA-Binding Proteins; Electrophoretic Mobility Shift Assay; HT29 Cells; Humans; Hypoglycemic Agents; Immunoenzyme Techniques; Immunologic Factors; Ligands; NF-kappa B; Promoter Regions, Genetic; Prostaglandin D2; Proto-Oncogene Proteins c-bcl-2; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic | 2002 |
Stimulation of peroxisome proliferator-activated receptors alpha and gamma blocks HIV-1 replication and TNFalpha production in acutely infected primary blood cells, chronically infected U1 cells, and alveolar macrophages from HIV-infected subjects.
Topics: Acquired Immunodeficiency Syndrome; Anti-HIV Agents; Cell Line; Chromans; Fenofibrate; HIV-1; Humans; Leukocytes, Mononuclear; Macrophages, Alveolar; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Necrosis Factor-alpha; Virus Replication | 2002 |
Regulation of proinflammatory cytokines in human gestational tissues by peroxisome proliferator-activated receptor-gamma: effect of 15-deoxy-Delta(12,14)-PGJ(2) and troglitazone.
Topics: Amnion; Chorion; Chromans; Culture Techniques; Decidua; DNA; Female; Humans; Interleukin-6; Interleukin-8; L-Lactate Dehydrogenase; Ligands; NF-kappa B; Placenta; Pregnancy; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Necrosis Factor-alpha | 2002 |
15-PGJ2, but not thiazolidinediones, inhibits cell growth, induces apoptosis, and causes downregulation of Stat3 in human oral SCCa cells.
Topics: Apoptosis; Blotting, Western; Carcinoma, Squamous Cell; Cell Cycle; Cell Division; DNA Primers; DNA-Binding Proteins; Down-Regulation; Humans; Immunoenzyme Techniques; Immunologic Factors; Mouth Neoplasms; Phosphorylation; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; STAT3 Transcription Factor; Thiazoles; Thiazolidinediones; Trans-Activators; Transcription Factors; Tumor Cells, Cultured | 2002 |
Cyclooxygenase-2 expression by nonsteroidal anti-inflammatory drugs in human airway smooth muscle cells: role of peroxisome proliferator-activated receptors.
Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Survival; Cyclooxygenase 2; Dexamethasone; Dinoprostone; Flurbiprofen; Humans; Indomethacin; Isoenzymes; Lung; Membrane Proteins; Muscle, Smooth; NF-kappa B; Nitrobenzenes; Promoter Regions, Genetic; Prostaglandin Antagonists; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Protein Transport; Receptors, Cytoplasmic and Nuclear; Response Elements; Sulfonamides; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation | 2003 |
Peroxisome proliferator-activated receptor gamma ligands increase release of nitric oxide from endothelial cells.
Topics: Animals; Aorta; Cells, Cultured; Endothelium, Vascular; Enzyme Induction; Humans; Immunologic Factors; Ligands; Nitric Oxide; Nitric Oxide Synthase; Prostaglandin D2; Pulmonary Artery; Receptors, Cytoplasmic and Nuclear; Swine; Thiazoles; Thiazolidinediones; Transcription Factors; Umbilical Veins | 2003 |
Activation of PPARgamma increases PTEN expression in pancreatic cancer cells.
Topics: DNA-Binding Proteins; Genes, Reporter; Humans; Ligands; Nuclear Proteins; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoric Monoester Hydrolases; Prostaglandin D2; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Repressor Proteins; Thiazoles; Thiazolidinediones; Transcription Factors; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2003 |
15d-PGJ2 and rosiglitazone suppress Janus kinase-STAT inflammatory signaling through induction of suppressor of cytokine signaling 1 (SOCS1) and SOCS3 in glia.
Topics: Animals; Anti-Inflammatory Agents; Astrocytes; Carrier Proteins; DNA-Binding Proteins; Gene Expression Regulation; Inflammation; Janus Kinase 1; Janus Kinase 2; Neuroglia; Phosphorylation; Prostaglandin D2; Protein Biosynthesis; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Repressor Proteins; Rosiglitazone; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 1 Protein; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Thiazoles; Thiazolidinediones; Trans-Activators; Transcription Factors | 2003 |
Activation of peroxisome proliferator-activated receptors in human airway smooth muscle cells has a superior anti-inflammatory profile to corticosteroids: relevance for chronic obstructive pulmonary disease therapy.
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Apoptosis; Blotting, Western; Cell Division; Cells, Cultured; Dexamethasone; DNA Fragmentation; Female; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Inhibitors; Humans; Interleukin-1; Ligands; Male; Middle Aged; Muscle, Smooth; Peroxisomes; Prostaglandin D2; Protein Isoforms; Pulmonary Disease, Chronic Obstructive; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Thiazolidinediones; Trachea; Transcription Factors | 2003 |
15-Deoxy-Delta(12,14)-prostaglandin J2 inhibits the expression of proinflammatory genes in human blood monocytes via a PPAR-gamma-independent mechanism.
Topics: Cyclooxygenase 2; Gene Expression; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunologic Factors; In Vitro Techniques; Inflammation; Interleukin-1; Interleukin-6; Isoenzymes; Lipopolysaccharides; Membrane Proteins; Monocytes; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Tumor Necrosis Factor-alpha | 2003 |
GATA-6 is involved in PPARgamma-mediated activation of differentiated phenotype in human vascular smooth muscle cells.
Topics: Actins; Cell Differentiation; Cells, Cultured; Chromans; Dimethyl Sulfoxide; DNA-Binding Proteins; GATA6 Transcription Factor; Humans; Immunohistochemistry; Muscle, Smooth, Vascular; Oligopeptides; Phenotype; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Troglitazone | 2003 |
Peroxisome proliferator-activated receptor gamma agonists induce proteasome-dependent degradation of cyclin D1 and estrogen receptor alpha in MCF-7 breast cancer cells.
Topics: Breast Neoplasms; Cell Division; Cyclin D1; Cysteine Endopeptidases; Down-Regulation; Estrogen Receptor alpha; G1 Phase; Humans; Multienzyme Complexes; Prostaglandin D2; Proteasome Endopeptidase Complex; Receptors, Cytoplasmic and Nuclear; Receptors, Estrogen; RNA, Messenger; S Phase; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured; Ubiquitin | 2003 |
Thrombomodulin expression by THP-1 but not by vascular endothelial cells is upregulated by pioglitazone.
Topics: Antibodies, Monoclonal; Blotting, Northern; CD4 Antigens; Cell Differentiation; Cell Line; Dose-Response Relationship, Drug; Endothelium, Vascular; Flow Cytometry; Gene Expression Regulation; HL-60 Cells; Humans; Lipopolysaccharide Receptors; Pioglitazone; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Thrombomodulin; Thromboplastin; Transcription Factors; Tumor Cells, Cultured; Up-Regulation | 2002 |
Cytokine regulation by peroxisome proliferator-activated receptor gamma in human endometrial cells.
Topics: Benzophenones; Colony-Stimulating Factors; Cytokines; Endometrium; Epithelial Cells; Female; Humans; Interleukin-6; Ligands; Phenylacetates; Prostaglandin D2; Protein Array Analysis; Protein Isoforms; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Tyrosine | 2003 |
15-deoxy-delta 12,14-prostaglandin J2 and laminar fluid shear stress stabilize c-IAP1 in vascular endothelial cells.
Topics: Apoptosis; Blotting, Western; Caspase 3; Caspases; Cell Nucleus; Cells, Cultured; Chromans; Cycloheximide; DNA; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Humans; Hypoglycemic Agents; Immunologic Factors; Inhibitor of Apoptosis Proteins; Intramolecular Oxidoreductases; Lipocalins; Luciferases; Microtubule-Associated Proteins; Neoplasm Proteins; Prostaglandin D2; Protein Biosynthesis; Protein Synthesis Inhibitors; Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stress, Mechanical; Survivin; Thiazoles; Thiazolidinediones; Troglitazone; Ubiquitin-Protein Ligases; Umbilical Veins | 2003 |
Peroxisome proliferator-activated receptor gamma ligand inhibits cell growth and invasion of human pancreatic cancer cells.
Topics: 3T3 Cells; Adenocarcinoma; alpha Catenin; Animals; Antineoplastic Agents; Apoptosis; beta Catenin; Cadherins; Caspase 3; Caspase 8; Caspase 9; Caspases; Cell Cycle; Cell Cycle Proteins; Cell Division; Collagen; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; Cyclooxygenase 2; Cytoskeletal Proteins; Drug Combinations; Enzyme Induction; Gene Expression Regulation, Neoplastic; Humans; Isoenzymes; Laminin; Ligands; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Membrane Proteins; Mice; Neoplasm Invasiveness; Neoplasm Proteins; Pancreatic Neoplasms; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Proteoglycans; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Trans-Activators; Transcription Factors; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2002 |
Inhibition of proliferation and estrogen receptor signaling by peroxisome proliferator-activated receptor gamma ligands in uterine leiomyoma.
Topics: Animals; Cell Division; Chromans; Docosahexaenoic Acids; Estradiol; Female; Humans; Leiomyoma; Ligands; Prostaglandin D2; Protein Isoforms; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Estrogen; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Cells, Cultured; Uterine Neoplasms | 2003 |
DR1-like element in human topoisomerase IIalpha gene involved in enhancement of etoposide-induced apoptosis by PPARgamma ligand.
Topics: Antigens, Neoplasm; Apoptosis; Chromans; DNA Topoisomerases, Type II; DNA-Binding Proteins; Electrophoretic Mobility Shift Assay; Etoposide; Flow Cytometry; Gene Expression; Humans; Jurkat Cells; Leukemia; Ligands; Mutagenesis; Phosphoproteins; Promoter Regions, Genetic; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Thiazoles; Thiazolidinediones; Topoisomerase II Inhibitors; Transcription Factors; Transfection; Troglitazone; Tumor Cells, Cultured | 2003 |
Activation-induced PPARgamma expression sensitizes primary human T cells toward apoptosis.
Topics: Apoptosis; Cysteine Proteinase Inhibitors; Gene Expression Regulation; Humans; Hydrazines; Jurkat Cells; Lymphocyte Activation; Lymphopenia; Nitrogen Oxides; Phytohemagglutinins; Promoter Regions, Genetic; Prostaglandin D2; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes; Thiazoles; Thiazolidinediones; Transcription Factors | 2003 |
The antiproliferative effects of PPARgamma ligands in normal human mammary epithelial cells.
Topics: Apoptosis; Breast; Cell Cycle; Cell Division; Cells, Cultured; Epithelial Cells; Female; Gene Expression; Humans; Hypoglycemic Agents; Ligands; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Repressor Proteins; Thiazoles; Thiazolidinediones; Transcription Factors | 2003 |
Effects of peroxisome proliferator-activated receptor gamma ligands ciglitazone and 15-deoxy-delta 12,14-prostaglandin J2 on rat cultured cerebellar granule neuronal viability.
Topics: Animals; Cell Survival; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Gene Expression Regulation; Ligands; Neurons; Prostaglandin D2; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors | 2003 |
Peroxisome proliferator-activated receptor-gamma represses GLUT4 promoter activity in primary adipocytes, and rosiglitazone alleviates this effect.
Topics: Adipocytes; Animals; CHO Cells; Cricetinae; Dimerization; Fibroblasts; Gene Expression Regulation; Genetic Complementation Test; Glucose Transporter Type 4; Humans; Hypoglycemic Agents; Immunologic Factors; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Promoter Regions, Genetic; Prostaglandin D2; Protein Structure, Tertiary; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Rosiglitazone; Suppression, Genetic; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic | 2003 |
Human invasive trophoblasts transformed with simian virus 40 provide a new tool to study the role of PPARgamma in cell invasion process.
Topics: Antigens, Polyomavirus Transforming; Cell Division; Cell Transformation, Viral; Cells, Cultured; DNA Primers; Dose-Response Relationship, Drug; Humans; Immunoblotting; Nuclear Proteins; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rosiglitazone; Simian virus 40; Thiazoles; Thiazolidinediones; Transcription Factors; Transfection; Trophoblasts | 2003 |
Peroxisome proliferator-activated receptor-gamma agonists modulate macrophage activation by gram-negative and gram-positive bacterial stimuli.
Topics: Animals; Cells, Cultured; Chromans; Enzyme Activation; Escherichia coli; Gram-Negative Bacteria; Gram-Positive Bacteria; I-kappa B Proteins; Inflammation Mediators; Lipopolysaccharides; Macrophage Activation; Macrophages, Peritoneal; Mitogen-Activated Protein Kinases; Nitric Oxide; Phosphorylation; Prostaglandin D2; Rats; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Staphylococcus aureus; Thiazoles; Thiazolidinediones; Thromboxane B2; Transcription Factors; Troglitazone | 2003 |
Peroxisome proliferator-activated receptor-gamma upregulates caveolin-1 and caveolin-2 expression in human carcinoma cells.
Topics: Adenocarcinoma; Antigens, Differentiation; Antigens, Neoplasm; Breast Neoplasms; Caveolin 1; Caveolin 2; Caveolins; Cell Differentiation; Cell Line; Chromans; Colonic Neoplasms; Dimerization; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Genes, Dominant; Humans; Kidney; Ligands; Macromolecular Substances; Membrane Microdomains; Neoplasm Proteins; Phenotype; Phenylacetates; Prostaglandin D2; Protein Structure, Tertiary; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; RNA, Neoplasm; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Troglitazone; Tumor Cells, Cultured | 2003 |
Role of PPAR-gamma ligands in neuroprotection against glutamate-induced cytotoxicity in retinal ganglion cells.
Topics: Animals; Antioxidants; Buthionine Sulfoximine; Cell Line, Transformed; Cell Survival; Chromans; Cytoprotection; Glutamic Acid; Ligands; Neuroprotective Agents; Prostaglandin D2; Rats; Receptors, Cytoplasmic and Nuclear; Retinal Ganglion Cells; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2003 |
PPARgamma inhibition of cyclooxygenase-2, PGE2 synthase, and inducible nitric oxide synthase in cardiac myocytes.
Topics: Anilides; Animals; Cells, Cultured; Chromans; Cyclooxygenase 2; Gene Expression Regulation; Interleukin-1; Intramolecular Oxidoreductases; Isoenzymes; Myocytes, Cardiac; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin D2; Prostaglandin-E Synthases; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2003 |
Peroxisome proliferator-activated receptor-gamma ligand inhibition of RANTES production by human endometriotic stromal cells is mediated through an upstream promoter element.
Topics: Base Sequence; Cells, Cultured; Chemokine CCL5; Endometriosis; Female; Humans; Ligands; Mutagenesis, Site-Directed; Promoter Regions, Genetic; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Response Elements; Rosiglitazone; Stromal Cells; Thiazoles; Thiazolidinediones; Transcription Factors; Transfection | 2003 |
Selective activation of PPARgamma inhibits pancreatic cancer invasion and decreases expression of tissue plasminogen activator.
Topics: Chromans; Humans; Integrins; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Pancreatic Neoplasms; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Tissue Plasminogen Activator; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2003 |
Apoptosis in human oral squamous cell carcinomas is induced by 15-deoxy-delta 12,14-prostaglandin J2 but not by troglitazone.
Topics: Amino Acid Chloromethyl Ketones; Analysis of Variance; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Caspase Inhibitors; Caspases; Cell Survival; Chromans; Cysteine Proteinase Inhibitors; Cytochrome c Group; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Immunologic Factors; Mouth Neoplasms; Oligopeptides; Prostaglandin D2; Signal Transduction; Thiazoles; Thiazolidinediones; Time Factors; Troglitazone; Tumor Cells, Cultured | 2003 |
Oxidized low density lipoprotein activates peroxisome proliferator-activated receptor-alpha (PPARalpha) and PPARgamma through MAPK-dependent COX-2 expression in macrophages.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Cell Line; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Fatty Acids, Unsaturated; Gene Expression Regulation, Enzymologic; Humans; Lipoproteins, LDL; Macrophages, Peritoneal; MAP Kinase Signaling System; Meloxicam; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; PPAR alpha; PPAR gamma; Prostaglandin D2; RNA, Messenger; Sulfonamides; Thiazines; Thiazoles | 2008 |
The effects of isoimperatorin isolated from Angelicae dahuricae on cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells.
Topics: Angelica; Animals; Arachidonate 5-Lipoxygenase; Bone Marrow Cells; Butanols; Cell Survival; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Electrophoresis, Polyacrylamide Gel; Furocoumarins; Hexosaminidases; Leukotriene C4; Lipoxygenase Inhibitors; Male; Mast Cells; Mice; Mice, Inbred BALB C; Plant Extracts; Plant Roots; Prostaglandin D2; Solvents; Tetrazolium Salts; Thiazoles | 2008 |
Exploring the cyclooxygenase 2 (COX2)/15d-Δ(12,14)PGJ(2) system in hamster Sertoli cells: regulation by FSH/testosterone and relevance to glucose uptake.
Topics: Androgen Antagonists; Anilides; Animals; Butadienes; Cricetinae; Cyclooxygenase 2; Deoxyglucose; Follicle Stimulating Hormone; Glucose; Male; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Meloxicam; Mesocricetus; Nitriles; Phosphorylation; Prostaglandin D2; Sertoli Cells; Testosterone; Thiazines; Thiazoles; Tosyl Compounds | 2012 |
Juvenile ovary to testis transition in zebrafish involves inhibition of ptges.
Topics: Animals; beta Catenin; Cyclooxygenase Inhibitors; Dinoprostone; Embryo, Nonmammalian; Female; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Intramolecular Oxidoreductases; Male; Meloxicam; Ovary; Prostaglandin D2; Prostaglandin-E Synthases; Sex Determination Processes; Sex Ratio; Signal Transduction; SOX9 Transcription Factor; Testis; Thiazines; Thiazoles; Zebrafish; Zebrafish Proteins | 2014 |
The roles of prostaglandin E2 and D2 in lipopolysaccharide-mediated changes in sleep.
Topics: Animals; Body Temperature; Cyclooxygenase Inhibitors; Dinoprostone; Lipopolysaccharides; Meloxicam; Mice; Mice, Knockout; Prostaglandin D2; Receptors, Prostaglandin E, EP3 Subtype; Receptors, Prostaglandin E, EP4 Subtype; Sleep; Thiazines; Thiazoles | 2015 |