thiazoles has been researched along with piperidines in 619 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 76 (12.28) | 18.7374 |
| 1990's | 194 (31.34) | 18.2507 |
| 2000's | 127 (20.52) | 29.6817 |
| 2010's | 182 (29.40) | 24.3611 |
| 2020's | 40 (6.46) | 2.80 |
| Authors | Studies |
|---|---|
| Schleicher, E | 1 |
| Haslbeck, M; Kemmler, W; Mehnert, H; Renner, R; Schneider, B | 1 |
| Kopp, H | 2 |
| Biamino, G; Kopp, H; Rudroff, W; Schneider, B | 1 |
| Bierkenmayer, E; Ganser, V; Heldt, W; Herrmann, M; Steinbrecher, W | 1 |
| Herrmann, M; Tauschel, HD | 1 |
| Hermann, M; Tauschel, HD | 1 |
| Herrmann, M; Leuschner, F; Wiegleb, J | 2 |
| Ehret, I; Gladigau, V; Hengy, H | 1 |
| Bode, R; Hodenberg, AV; Poisson, A; Schauerte, E; Vollmer, KO | 1 |
| Hodenberg, AV; Klemisch, W; Vollmer, KO | 1 |
| Ehret, I; Gladigau, V | 1 |
| Friedrich, G; Vollmer, KO | 1 |
| Satzinger, G | 1 |
| Bahrmann, H; Birkenmayer, E; Ganser, V; Heldt, W; Herrmann, M; Steinbrecher, W | 1 |
| Greven, J; Heidenreich, O | 1 |
| Gladigau, V; Hengy, H; Poisson, A; Vollmer, KO; von Hodenberg, A | 1 |
| Gladigau, V; Vollmer, KO | 1 |
| Chasseaud, LF; Franklin, ER; Taylor, T | 1 |
| Scheitza, E | 2 |
| Biamino, G | 1 |
| Goossens, N; Marshall, M | 1 |
| Abri, AR | 1 |
| Frankow, C; Peters, T; Tegtmeier, F; Thoné, F; Vandeplassche, L; Wilhelm, D | 1 |
| Hashii, H; Horiba, M; Matsubara, S; Nabe, T; Ohata, K; Watanabe-Kohno, S; Yamamura, H; Yasui, K | 1 |
| Haigney, MC; Lakatta, EG; Miyata, H; Silverman, HS; Stern, MD | 1 |
| Leidig, A; Nebel, U; Peters, T; Wermelskirchen, D; Wilffert, B; Wirth, A | 1 |
| Banga, JD; Hendriksen, PH; Oey, PL; van Dam, PS; Wieneke, GH | 1 |
| Bodnar, RJ; Hough, LB; Koch, JE | 1 |
| Hough, LB; Nalwalk, JW | 2 |
| Chakravarty, AK; Puri, S; Ray, A; Sen, P | 1 |
| Leysen, JE; Moeremans, M; Pauwels, PJ; Peeters, L; Van Assouw, HP | 1 |
| Heers, C; Peters, T; Scheufler, E; Wermelskirchen, D; Wilffert, B; Wilhelm, D | 1 |
| Cornelissen, F; De Brabander, M; Geerts, H; Janssen, PA; Mandelkow, EM; Nuydens, R; Nuyens, R; Pauwels, P; Song, YH | 1 |
| Daniels, MC; ter Keurs, HE | 1 |
| Gwilt, M; Henderson, CG; Orme, J; Rourke, JD | 1 |
| Borgers, M; Geerts, H; Ver Donck, L; Verellen, G | 1 |
| Clincke, B; De Deyn, PP; Pickut, BA; Saerens, J; Van de Velde, V; Van Peer, A; Verslegers, W; Woestenborghs, R | 1 |
| Beile, A; Guttmann, I; Osikowska-Evers, B; Peters, T; Scheufler, E; Tegtmeier, F; Urenjak, J; Wilffert, B | 1 |
| Law, RO | 1 |
| Gleitz, J; Peters, T; Tegtmeier, F; Urenjak, J; Wermelskirchen, D; Wilffert, B | 1 |
| Bernier, M; Borgers, M; Hearse, DJ; Kusama, Y; Neckers, DC; Valdes-Aguilera, O; Ver Donck, L | 1 |
| Carmeliet, E; Tytgat, J | 1 |
| Borgers, M; Ver Donck, L | 1 |
| Bielen, FV; Ver Donck, L; Verdonck, F | 1 |
| Nebel, U; Peters, T; Wermelskirchen, D; Wilffert, B; Wirth, A | 1 |
| Himmel, H; Peters, T; Ravens, U; Wilhelm, D | 1 |
| Borgers, M; Thoné, F; Vandeplassche, G | 1 |
| Maeyama, K; Onodera, K; Sakai, N; Watanabe, T; Yanai, K | 1 |
| Colpaert, FC; Degryse, AD; Van Craenendonck, HV | 1 |
| Cai, ZJ; Li, M; Liu, LN; Liu, YH; Zhang, JL; Zheng, JW | 1 |
| Bajjou, R; Chaouche-Teyara, K; Dabiré, H; De Nanteuil, G; Fournier, B; Laubie, M; Safar, M; Schmitt, H | 1 |
| Bernier, M; Garner, JA; Hearse, DJ | 1 |
| Himmel, HM; Ravens, U; Wilhelm, D | 1 |
| Peters, T; Scheufler, E; Wilhelm, D | 1 |
| Borgers, M; Hermans, C; Vandeplassche, G; Wouters, L | 1 |
| Damiano, BP; Stump, GL; Yagel, SK | 1 |
| Hlinák, Z; Krejcí, I | 2 |
| Carmeliet, E; Leyssens, A | 1 |
| Blanchard, JC; Comte, MT; Doble, A; Gueremy, C; Huon, C; Malleron, JL; Peyronel, JF; Piot, O; Truchon, A; Zundel, JL | 1 |
| Boussard, M; Jantos, H; Monti, JM; Olivera, S; Orellana, C | 1 |
| Battles, AH; Hough, LB; Nalwalk, JW | 1 |
| Ashton, D; Werbrouck, L | 1 |
| Nebel, U; Wermelskirchen, D; Wilffert, B; Wirth, A | 1 |
| de Chaffoy de Courcelles, D | 1 |
| De Ryck, M; Duytschaever, H; Janssen, PA; Pauwels, PJ | 1 |
| Carmeliet, E; Luk, HN | 1 |
| Chapman, RA; Rodrigo, GC | 1 |
| Scheufler, E; Vogelgesang, R | 1 |
| Peters, T; Scheufler, E | 1 |
| Borgers, M; De Clerck, F; Vandewiele, R; Ver Donck, L; Verellen, G | 1 |
| Eberle, NB; Glick, SD; Gogas, KR; Hough, LB; Lyon, RA; Parsons, ME; Ward, SJ; Young, RC | 1 |
| Koch, P; Peters, T; Wilffert, B; Wilhelm, D | 1 |
| Gogas, KR; Hough, LB | 3 |
| D'Angio, M; Scatton, B; Serrano, A | 1 |
| Walt, RP | 1 |
| Emami, S; Fagot, D; Gespach, C | 1 |
| Domae, M; Furukawa, T; Matsumoto, S; Nagashima, M; Shirakawa, K; Yamada, K | 1 |
| Bravo, G; Finet, M; Godfraind, T | 1 |
| Robbins, TW | 1 |
| Aono, M; Mizuta, K; Moriga, M; Narusawa, H | 1 |
| Calcutt, CR; Ganellin, CR; Griffiths, R; Leigh, BK; Maguire, JP; Mitchell, RC; Mylek, ME; Parsons, ME; Smith, IR; Young, RC | 1 |
| Brockmeier, D; Lameire, N; Rosenkranz, B | 1 |
| Amery, WK; Clincke, GH; Idzikowski, C; Janssen, PA; Tritsmans, L | 1 |
| Amery, WK; Clincke, G; Tritsmans, L | 1 |
| Clincke, GH; Tritsmans, L | 1 |
| Camarota, NA; Cue, D; Eberle, N; Gogas, KR; Hough, LB; Jackowski, S | 1 |
| Koch, P; Nebel, U; Peters, T; Wermelskirchen, D; Wilffert, B; Wilhelm, D | 1 |
| Janssen, PA; Meuter, C; Vollmer, B | 1 |
| Passow, H; Raida, M | 1 |
| Ebringer, L; Foltínová, P; Lahitová, N | 1 |
| Moore, KE; Thornburg, JE | 1 |
| Lechat, P; Streichenberger, G | 1 |
| Kreutzberger, A; Uzbek, MU | 2 |
| Koss, FW; Vollmer, KO | 1 |
| Herrmann, M; Koss, FW; Vollmer, KO | 1 |
| Arimura, K; Nakanishi, M | 2 |
| Haller, R; Hawlitzky, N | 1 |
| Kato, M; Kobayashi, A; Umemoto, S | 1 |
| Besiadetskaia, EI | 1 |
| Bayerdoerffer, E; Eveloff, J; Kinne, R; Kinne-Saffran, E; Koenig, B | 1 |
| Antonacci, AC | 1 |
| Amano, H; Juhn, SK; Lessmann, FJ; Morgenstern, C; Orsulakova, A | 1 |
| Göttl, KH; Klinke, R; Roesch, A | 1 |
| Heidenreich, O; Heintze, K; Petersen, KU | 1 |
| Defrain, W; Glaser, K; Greven, J; Heidenreich, O; Meywald, K | 1 |
| Beckers, M; Defrain, W; Greven, J; Heidenreich, O; Meywald, K | 1 |
| Gladigau, V; Hengy, H; Kölle, EU; Vollmer, KO | 1 |
| Liddiard, C; Nau, H | 1 |
| Imaizumi, M; Miyazaki, S; Onodera, K | 2 |
| Bergstrom, DA; Gonzalez, AM; Huang, KX; Kreiss, DS; Sibley, DR; Walters, JR | 1 |
| Fleckenstein, AE; Lookingland, KJ; Moore, KE | 2 |
| Hoff, P; Tegtmeier, F; Xie, Y; Zacharias, E | 1 |
| Wong, CL | 1 |
| Aldenkamp, AP; Beun, AM; Diepman, L; Edelbroek, P; Gutter, T; Mulder, OG; Overweg, J; Smakman, J; Vledder, B; vt Slot, B | 1 |
| Ansorge, S; Kähne, T; Neubert, K | 1 |
| Barke, KE; Bodnar, RJ; Hough, LB; Koch, JE; Nalwalk, JW | 1 |
| Coraboeuf, E; John, GW; Le Grand, B; Talmant, JM; Vie, B | 1 |
| Park, SR; Ryu, GH; Suh, CK | 1 |
| David, GK; Koch, K; Koolen, JJ; Piek, JJ; Pijl, AJ; Swaan, A; Van Wezel, HB; Van Zwieten, PA; Visser, CA | 1 |
| Dahlström, AB; Li, JY | 1 |
| De Clerck, F; Lu, HR | 1 |
| McGarry, SJ; Scheufler, E; Williams, AJ | 1 |
| De Courtois, F; John, GW; Le Grand, B; Pouget, G; Verscheure, Y | 1 |
| Klein, HH; Lindert-Heimberg, S; Maisch, B; Nebendahl, K; Pich, S | 1 |
| Ansorge, S; Bank, U; Bühling, F; Faust, J; Kähne, T; Kunt, D; Neubert, K; Reinhold, D | 1 |
| Misawa, M; Onodera, K; Suzuki, T; Takamori, K | 1 |
| Carson, CC; Davies, MG; Hagen, PO; Kim, YC; Lee, TH | 1 |
| Lin, MY; Walters, DE | 1 |
| Carlsson, A; Huff, RM; Kling-Petersen, T; Svensson, K; Waters, N | 1 |
| Adami, M; Bertaccini, G; Coruzzi, G; Poli, E; Pozzoli, C | 1 |
| Hendriks, MG; Kam, KL; Paffendorf, M; Pijl, AJ; van Zwieten, PA | 1 |
| Bindels, RJ; Couwenberg, P; Jansen, JW; Rose, UM; Van Os, CH | 1 |
| Schilling, L; Wahl, M | 1 |
| Barta-Szalai, G; Domány, G; Pálosi, E; Schön, I; Szabó, S | 1 |
| Kuczyńska, E; Ziomko, I | 1 |
| Haigney, MC; Lakatta, EG; Silverman, HS; Stern, MD | 1 |
| Adachi, N; Hirakawa, M; Itano, Y; Oishi, R; Saeki, K; Yamada, T | 1 |
| Gerlach, J; Peacock, L | 1 |
| Coetzee, WA; Hearse, DJ; Ichikawa, H | 1 |
| Borgers, M; Chen, CC; Flameng, W; Lin, W; Masuda, M; Morishige, N; Mubagwa, K; Thoné, F; Wieland, W | 1 |
| Gorgels, AP; Leunissen, JD; van Deursen, RT; Vos, MA; Wellens, HJ | 1 |
| Coronel, R; Janse, MJ; Mazón, P; Netea, AO; Opthof, T; Sleeswijk, ME; Tan, HL | 1 |
| Heers, C; Peters, T; Pierce, GN; Scheufler, E; Wilffert, B | 1 |
| Krzan, M; Vodusek, DB; Vrtovec, M; Zgur, T | 1 |
| Albillos, A; Artalejo, AR; de la Fuente, MT; Gandía, L; Garcez-Do-Carmo, L; García, AG; López, MG; Michelena, P | 1 |
| Krishtal, OA; Panchenko, VA; Tegtmeier, F | 1 |
| Borgers, M; Ver Donck, L; Verdonck, F | 1 |
| Chizhmakov, IV; Kiskin, NI; Krishtal, OA; Tegtmeier, F | 1 |
| Vondrácková, D | 1 |
| Elhilali, MM; Gagnon, C; Hassan, AA; Hassouna, MM; Taketo, T | 1 |
| Van der Valk, JB; Vijverberg, HP | 1 |
| Cerný, R; Egerová, Y; Krejcová, H; Vondrácková, D | 1 |
| Hlinák, Z; Krejcí, I; Schuh, J | 1 |
| De Clerck, F; Lu, HR; Remeysen, P | 1 |
| Guttmann, I; Mozes, A; Scheufler, E; Wilffert, B | 1 |
| De Keyser, J; Diener, HC; Hacke, W; Hantson, L; Hennerici, M; Rådberg, J | 1 |
| D'Souza, T; Dryer, SE; Nowak, JZ; Sek, B | 1 |
| Cambarrat, C; Iliou, JP; Robin, F; Thollon, C; Vilaine, JP | 1 |
| Kellerman, TS; Maartens, BP; Mülders, MS; Schultz, RA; Swan, GE; Van der Walt, JJ | 1 |
| Ishide, N | 1 |
| Arita, J; Eto, K; Hashimoto, K; Ni, C; Sugiyama, A; Xue, YX | 1 |
| Blandina, P; Cecchi, M; Giorgetti, M; Giovannini, MG; Leurs, R; Timmerman, H | 1 |
| Blanchard, DC; Blanchard, RJ; Griebel, G; Guardiola-Lemaître, B; Rettori, MC | 1 |
| Barta-Szalai, G; Domány, G; Ezer, E; Matúz, J; Schön, I | 1 |
| Ejnell, H; Eriksson, B; Grunstein, R; Hedner, J | 1 |
| Aronowski, J; Grotta, JC; Strong, R | 2 |
| De la Fuente, MT; Esquerro, E; García, AG; Maroto, R; Sánchez-García, P | 1 |
| Eaton, SJ; Eoh, S; Harrington, ME; Hoque, S; Meyer, J | 1 |
| Claes, C; Clincke, G; De Ryck, M; Duytschaever, H; Janssen, M; Keersmaekers, R; Van Reet, G | 1 |
| Lesage, AS; Leysen, JE; Peeters, L | 1 |
| Obrenovitch, TP | 1 |
| Kue, I; Maiese, K; TenBroeke, M | 1 |
| Ashton, D; Clincke, G; Marrannes, R; Van Reempts, J; Willems, R; Wynants, J | 1 |
| Borgers, M; Haseldonckx, M; Van de Ven, M; Van Reempts, J; Wouters, L | 1 |
| Buchkremer-Ratzmann, I; Witte, OW | 1 |
| Galli, P; Grilli, M; Lesage, A; Memo, M; Pizzi, M; Rizzini, C; Spano, P; Uberti, D | 1 |
| Ito, C; Onodera, K; Sato, M; Watanabe, T | 1 |
| Hérault, JP; Herbert, JM; Lalé, A; Pflieger, AM; Savi, P | 1 |
| Dyker, AG; Lees, KR | 1 |
| Hayashi, Y; Kagawa, K; Mammoto, T; Mashimo, T; Yamamoto, Y; Yamatodani, A; Yoshiya, I | 1 |
| Chou, CC; Jenh, CH; Lundell, D; Narula, S; Prosser, D; Taremi, S; Tsarbopoulos, A; Wiekowski, M; Zavodny, P | 1 |
| Bolognese, A; Capasso, F; Diurno, MV; Izzo, AA; Mazzoni, O | 1 |
| Imaizumi, M; Miyazaki, S; Onodera, K; Timmerman, H | 1 |
| Belanger, G; Mendis, T; Mohr, E; Murtha, S; Nair, NP; Pappas, B; Sampson, M | 1 |
| Bernat, A; Herbert, JM; Hoffmann, P; Savi, P | 2 |
| de Pascual, R; Gandía, L; García, AG; Hernández-Guijo, JM | 1 |
| Badorc, A; Bernat, A; Bordes, MF; de Cointet, P; Herbert, JM; Lalé, A; Maffrand, JP; Petitou, M; Savi, P | 1 |
| Crabbé, R; Gheuens, J; Hantson, L; Tritsmans, L; Van Rooy, P | 1 |
| Grotta, J | 3 |
| Clincke, G; de Ryck, M; Scheller, D; Tegtmeier, F | 1 |
| Clincke, G; De Ryck, M; Kolb, J; Scheller, DK; Szathmary, S; Tegtmeier, F; van Reempts, J | 1 |
| Gandía, L; García, AG; Lara, B; Martínez-Sierra, R; Torres, A | 1 |
| Bernat, A; Herault, JP; Herbert, JM; Peyrou, V; Savi, P | 1 |
| Bakhos, M; Ero, M; Haas, S; Herbert, JM; Jeske, WP; Szatkowski, E; Walenga, JM | 1 |
| Culmsee, C; Junker, V; Krieglstein, J; Semkova, I; Wolz, P | 1 |
| Itoh, C; Onodera, K; Sato, M; Watanabe, T | 1 |
| Brandeis, R; Chapman, S; Fisher, A; Michaelson, DM; Pittel, Z | 1 |
| Hirakawa, N; Kashiwaba, N; Kutsuma, T; Matsumoto, H; Sekine, A; Sekine, Y; Yamaura, T | 1 |
| Adachi, Y; Akima, M; Fukazawa, M; Kato, T; Koga, T; Kuromaru, O; Suzuki, Y; Tamura, K | 1 |
| August, M; Buchkremer-Ratzmann, I; Hagemann, G; Witte, OW | 1 |
| Coulombe, A; John, GW; Le Grand, B | 1 |
| Lodder, J | 1 |
| Lees, KR | 1 |
| Clincke, G; De Prins, E; Marrannes, R | 1 |
| Herbert, JM; Jeske, WP; Savi, P; Walenga, JM | 1 |
| Cano-Abad, MF; Gandía, L; García, AG; Hernández-Guijo, JM; López, MG; Sánchez-García, P; Zapater, P | 1 |
| Ansorge, S; Faust, J; Kähne, T; Neubert, K | 1 |
| Badorc, A; Bernat, A; Bordes, MF; Bornia, J; de Cointet, P; Herbert, JM; Hoffmann, P; Labouret, C; Lalé, A; Maffrand, JP; Savi, P | 1 |
| Crabbe, R; Hantson, L; Heykants, J; Van de Velde, V; Van Osselaer, N; Van Peer, A; Woestenborghs, R | 1 |
| Cascieri, MA; Chicchi, GG; Graham, MI; Harrison, T; Huscroft, I; Kelleher, FJ; Kurtz, M; Ladduwahetty, T; MacIntyre, DE; MacLeod, AM; Merchant, KJ; Metzger, JM; Owens, AP; Sadowski, S; Sohal, B; Stevenson, GI; Swain, CJ | 1 |
| Hérault, JP; Herbert, JM; Li, N; Savi, P; Wallén, NH | 1 |
| Misawa, M; Mori, T; Onodera, K; Suzuki, T; Tsuji, M | 1 |
| Krieger, J | 1 |
| Beard, DC; Billingsley, ML; Burkhart, KK; Lehman, RA | 1 |
| Fisher, A; Genis, I; Michaelson, DM | 1 |
| Grotta, J; Hickenbottom, SL | 1 |
| Demchuk, AM; Hantson, L; Jauss, M; Kasner, SE; Krieger, DW | 1 |
| Funato, H; Kohsaka, S; Mochizuki, H; Shimojo, M; Takasugi, K; Yamamoto, I | 1 |
| Dai, DZ; De Clerck, F; Lu, HR; Remeysen, P; Saels, A; Yang, P | 1 |
| Bertaccini, G; Coppelli, G; Coruzzi, G; Poli, E; Pozzoli, C | 1 |
| Adachi, Y; Fukazawa, M; Homma, N; Kuromaru, O; Nishie, I; Suzuki, Y; Tamura, K | 1 |
| Himmel, HM; Ravens, U | 1 |
| Aron, ZD; Fink, BE; Katzenellenbogen, JA; Mortensen, DS; Stauffer, SR | 1 |
| Bernat, A; Herbert, JM; Hoffmann, P; Lale, A; Savi, P | 2 |
| Inokuchi, A; Komiyama, S; Liu, F; Ureshino, M; Yokomitsu, S | 1 |
| Adang, AE; de Zwart, E; Gerritsma, S; Peters, AM; Veeneman, G | 1 |
| Meade, HM; Seeley, NA; Sturman, G | 1 |
| Lawrence, C; Rodrigo, GC | 1 |
| Chaki, S; Kawashima, N; Nakamura, A; Okuyama, S; Tomisawa, K | 1 |
| Kern, M; Kroppenstedt, SN; Schneider, GH; Stroop, R; Thomale, UW; Unterberg, AW | 1 |
| DeFronzo, RA | 1 |
| Barbieri, M; Nistri, A | 1 |
| Ruske, AC; White, KG | 1 |
| Feinglos, MN; Hughes, AT; Luna, B | 1 |
| Arita, M; Li, Y; Sato, T | 1 |
| Hanke, W; Wiedemann, M | 1 |
| Bankhead, C | 1 |
| Chaki, S; Funakoshi, T; Ikeda, Y; Kawashima, N; Kumagai, T; Nagamine, M; Nakazato, A; Ogawa, SI; Okuyama, S; Suzuki, Y; Tomisawa, K; Yoshikawa, R | 1 |
| Smits, P; Tack, CJ | 1 |
| Chaki, S; Kawashima, N; Okuyama, S; Omura, T; Tomisawa, K | 1 |
| Brillon, D; Brown, DL | 1 |
| Mozersky, RP | 1 |
| Chen, Z; Fujii, Y; Kamei, C; Sugimoto, Y; Suzuki, G | 1 |
| Breddin, HK; Graff, J; Harder, S; Hild, M; Kirchmaier, CM; Klinkhardt, U; Mahnel, R; Westrup, D | 1 |
| Maiese, K; Vincent, AM | 2 |
| Larmore, SS | 1 |
| De Ryck, M; Van der Linden, AM; Verhoye, M | 1 |
| Breddin, HK; Graff, J; Harder, S; Kirchmaier, CM; Klinkhardt, U; Mahnel, R; Westrup, D | 1 |
| Bailey, CJ; Nattrass, M | 1 |
| Kamiki, T; Kohno, S; Nabe, T; Tanpo, T; Yasui, K | 1 |
| Berger, S; Jovanovic, L; Raskin, P; Ratner, R; Schwartz, S; Woo, V | 1 |
| Füchtenbusch, M; Schatz, H; Standl, E | 1 |
| Bernat, A; Herbert, JM; Lalé, A; Roque, C; Savi, P; Zamboni, G | 1 |
| De Prins, E; Marrannes, R | 1 |
| Cortens, M; Diener, HC; Ford, G; Grotta, J; Hacke, W; Kaste, M; Koudstaal, PJ; Wessel, T | 1 |
| Dippel, DW; Du Ry van Beest Holle, M; Koudstaal, PJ; van Kooten, F | 1 |
| Fisher, M; Schaebitz, W | 1 |
| Que, M; Witte, OW; Zilles, K | 1 |
| Fisher, A | 2 |
| Carlton, FB | 1 |
| Alfranca, A; Aragonés, J; Jones, DR; Landázuri, MO; Martin, S; Mérida, I; San Juan, MA; Vara, A; Vidal, F | 1 |
| Fareed, J; Herbert, JM; Herring, J; Hoppensteadt, DA; Jeske, W; Orcullo Santillan, MK | 1 |
| Affricano, D; Angelucci, L; Lombardo, K; Nicolai, R; Scaccianoce, S | 1 |
| Blackburn, G | 1 |
| Moses, R | 2 |
| Gudelsky, GA; Vorhees, CV; Wallace, TL | 1 |
| Blin, O; Bouhours, P; Lacarelle, B; Le Moing, JP; Levron, JC; Micallef, J; Nataf, MB; Pageaux, GP | 1 |
| Anthonsen, T; Berg, TC; Hoff, BH; Liu, HL | 1 |
| Koinig, H; Rueda, C; Vornik, V; Zornow, MH | 1 |
| Herbert, JM; Rescanières, O; Savi, P; Zamboni, G | 1 |
| Fu, Y; Tang, XC; Zhou, J | 1 |
| Blagosklonny, MV | 1 |
| Beach, TG; Fisher, A; Potter, PE; Sue, LI; Walker, DG | 1 |
| Chaki, S; Funakoshi, T; Kameo, K; Kawashima, N; Okuyama, S; Omura, T | 1 |
| Laws, A | 1 |
| Boccuzzi, SJ; Fox, J; Kim, J; Shah, AB; Sung, JC; Wogen, J | 1 |
| Chen, Z; Kamei, C | 1 |
| Albrecht, J; Borkowska, HD; Hilgier, W; Oja, SS; Saransaari, P; Zielińska, M | 1 |
| Calvo Romero, JM; Lima Rodríguez, EM | 1 |
| Millan, MJ; Newman-Tancredi, A; Touzard, M; Verrièle, L | 1 |
| Benard, V; Gendreau, S; Missy, K; Payrastre, B; Plantavid, M; Soulet, C | 1 |
| Pospísilová, Y | 1 |
| Inzucchi, SE | 1 |
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| Cook, SA; Huang, D; Islam, O; Liew, R; Liu, Z; Loh, LJ; Lu, J; Ma, D; Shim, W; Wei, H | 1 |
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| Giordano, A; Morales, F | 1 |
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| Bhutkar, A; Chen, PY; Chung, KM; Dorans, KJ; Hong, E; Jacks, T; Muzumdar, MD; Noll, EM; Sprick, MR; Trumpp, A | 1 |
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| Asp, AJ; Benneyworth, MA; Ebner, SR; Hearing, MC; Ingebretson, AE; Larson, EB; Madayag, A; Schmidt, CE; Silvis, KA; Thomas, MJ | 1 |
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| Gobin, CM; Hámor, PU; Schwendt, M | 1 |
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| Chen, JJ | 1 |
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Yang, S; Yang, T; Yang, X; Yang, Y; Yao, H; Yao, Y; Yari, D; Yassin, MT; Ye, C; Ye, J; Ye, Q; Yildiz, EA; Ying, S; Yoon, H; Yu, D; Yu, K; Yu, N; Yu, PL; Yuan, C; Yuan, D; Yuan, LJ; Yuan, Z; Yuen, N; Zagatto, AM; Zakaria, Y; Zalewski, AM; Zamora, S; Zavorotinskaya, T; Zeid, JL; Zeinoun, T; Zeng, C; Zerby, HN; Zhan, X; Zhang, A; Zhang, D; Zhang, E; Zhang, F; Zhang, H; Zhang, J; Zhang, L; Zhang, M; Zhang, P; Zhang, Q; Zhang, QY; Zhang, RG; Zhang, S; Zhang, T; Zhang, X; Zhang, Y; Zhang, YY; Zhao, CK; Zhao, H; Zhao, J; Zhao, K; Zhao, Q; Zhao, S; Zhao, T; Zhao, XQ; Zhao, Y; Zhao, Z; Zheng, J; Zheng, L; Zheng, Y; Zhou, B; Zhou, G; Zhou, L; Zhou, T; Zhou, X; Zhu, C; Zhu, J; Zhu, Y; Zhu, ZQ; Zhuang, T; Zimmermannova, O; Zin, NNINM; Zisimos, K; Zoghebi, KA; Zonder, JA; Zou, C; Zwirner, J | 1 |
| Han, X; Lu, J; McEachern, D; Wang, S; Zhao, L | 1 |
| Budriesi, R; Caputo, L; Cavalluzzi, MM; Corazza, I; De Salvia, MA; Franchini, C; Gualdani, R; Lentini, G; Micucci, M; Milani, G; Piarulli, M; Quintieri, L; Rosato, A; Viale, M | 1 |
| Gabrail, N; Smith, C | 1 |
| Gu, L; Huang, YL; Wang, Y; Yang, HM; Zhang, H; Zhang, JN | 1 |
| El-Maghraby, WH; El-Malla, SF; Mabrouk, MM | 1 |
| Helm, J; Kuijlaars, M; McBrearty, A | 1 |
| Aguayo-Ortiz, R; Figueroa-Figueroa, DI; Hernández-Luis, F; Martínez-Ortega, U | 1 |
| Han, J; Huang, M; Luo, L; Ma, X; Shi, H; Su, C; Wang, A; Wang, H; Wang, W; Wu, K; Xu, T; Xu, X; Yuan, T | 1 |
| Azizi, SA; Baker, SC; Botten, JW; Brooke, CB; Bruce, EA; Chen, S; DeMarco, JK; Dickinson, BC; Drayman, N; Dvorkin, S; Firpo, MR; Froggatt, HM; Furlong, K; Han, KY; Heaton, NS; Jedrzejczak, R; Joachimiak, A; Jones, KA; Kathayat, RS; Lee, H; Maltseva, NI; Mastrodomenico, V; Meyer, B; Missiakas, D; Mounce, BC; Muñoz-Alía, MÁ; Nair, V; Nicolaescu, V; O'Brien, A; Palmer, KE; Randall, G; Schmidt, MM; Schuster, B; Severson, WE; Tan, K; Tay, S; Tomatsidou, A; Vignuzzi, M | 1 |
| Alamón, C; Barbeito, L; Hermine, O; Ibarburu, S; King, PH; Kovacs, M; Kwon, Y; Maciel, C; Si, Y; Tarragó, L; Trias, E; Varela, V | 1 |
| Cheng, B; Guo, H; Liu, W; Wang, H; Zhao, Q | 1 |
| Auladell, C; Camins, A; Cano, A; Ettcheto, M; Folch, J; Sanchez-López, E; Verdaguer, E | 1 |
| Collins-Praino, LE; Corrigan, F; Guglietti, B; Mustafa, S; Sivasankar, S | 1 |
| Bix, GJ; Fraser, JF; Gorman, A; Maniskas, ME; Roberts, JM | 1 |
| Ammar, YA; Bayoumi, AH; Ezz Eldin, RR; Fayed, EA; Ragab, A | 1 |
| Dou, Y; Eldstrom, J; Fedida, D; McAfee, DA; Wang, Y | 1 |
| Fong, IH; Lee, WH; Lin, IH; Pikatan, NW; Weng, PW; Yadav, VK; Yeh, CT | 1 |
| Akhtar, M; Akhtar, S; Haider, S; Saify, ZS; Shamim, S; Siddiqui, R | 1 |
| Demir-Dora, D; Goksu Erol, AY; Kocanci, FG; Uysal, H | 1 |
| Brieva-Ruiz, L; Fox, RJ; Hermine, O; Maciejowski, M; Mansfield, C; Moussy, A; Paul, F; Ramio-Torrenta, L; Schwab, M; Vermersch, P | 1 |
| Granados-Soler, JL; Hewicker-Trautwein, M; Klose, K; Murua Escobar, H; Nolte, I; Packeiser, EM | 1 |
| Eisner, JR; Lerner, LM; Michmerhuizen, AR; Pesch, AM; Pierce, LJ; Rae, JM; Schwartz, R; Speers, CW; Ward, C; Wilder-Romans, K; Zhang, A | 1 |
| Ataei, F; Dou, Y; Eldstrom, J; Fedida, D; Kyriakis, E; Russo, S; Sahakyan, H; Van Petegem, F; Willegems, K | 1 |
| Nagahara, Y; Semba, Y; Shinomiya, T; Takahashi, S; Yamamoto, S | 1 |
| Ancidoni, A; Carbone, E; Corbo, M; Crestini, A; Lacorte, E; Lo Giudice, M; Piscopo, P; Rivabene, R; Vanacore, N | 1 |
| Crouch, RD; Jackson, KD; Latham, BD; Oskin, DS; Vergne, MJ | 1 |
| Fukao, K; Fukasawa, H; Itai, A; Kato, T; Matsumura, KI; Muto, S; Naya, N; Ohara, T; Tokuyama, R | 1 |
76 review(s) available for thiazoles and piperidines
| Article | Year |
|---|---|
The use of diacylglycerol kinase inhibitors for elucidating the roles of protein kinase C.
Topics: Animals; Blood Platelets; Diacylglycerol Kinase; Diglycerides; Enzyme Activation; Humans; Neutrophils; Phosphotransferases; Piperidines; Protein Kinase C; Pyrimidinones; Quinazolines; Quinazolinones; Rabbits; Receptors, Cell Surface; Second Messenger Systems; Thiazoles | 1990 |
Clinical importance of the new H2-antagonists.
Topics: Animals; Famotidine; Histamine H2 Antagonists; Humans; Nizatidine; Peptic Ulcer; Piperidines; Thiazoles | 1989 |
Pharmacokinetics of histamine (H2)-receptor antagonists, including roxatidine, in chronic renal failure.
Topics: Anti-Ulcer Agents; Cimetidine; Famotidine; Histamine H2 Antagonists; Humans; Kidney Failure, Chronic; Piperidines; Ranitidine; Renal Dialysis; Thiazoles | 1988 |
Inhibition of sodium and calcium overload pathology in the myocardium: a new cytoprotective principle.
Topics: Benzothiazoles; Calcium; Calcium Channels; Heart; Heart Diseases; Humans; Myocardium; Piperidines; Potassium Channels; Sodium; Sodium Channels; Thiazoles | 1993 |
Intracellular calcium modulators for cardiac muscle in pathological conditions.
Topics: Animals; Anti-Arrhythmia Agents; Anticonvulsants; Arrhythmias, Cardiac; Benzothiazoles; Caffeine; Calcium; Calcium Channel Blockers; Dantrolene; Flunarizine; Homeostasis; Humans; Magnesium; Models, Cardiovascular; Muscle Relaxants, Central; Myocardial Contraction; Myocardium; Phenytoin; Piperidines; Ryanodine; Sarcoplasmic Reticulum; Thiazepines; Thiazoles | 1996 |
Sodium and potassium channel modulators: their role in neuroprotection.
Topics: Animals; Benzeneacetamides; Cell Survival; Disease Models, Animal; Lamotrigine; Neurons; Neuroprotective Agents; Piperazines; Piperidines; Potassium Channels; Pyrimidines; Riluzole; Sodium Channels; Thiazoles; Triazines | 1997 |
The rationale for new therapies in acute ischaemic stroke.
Topics: Cerebrovascular Disorders; Disease Models, Animal; Humans; Neuroprotective Agents; Piperidines; Plasminogen Activators; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Thiazoles; Thrombolytic Therapy; Tissue Plasminogen Activator | 1996 |
New frontiers in the management of obstructive sleep apnoea syndrome.
Topics: Combined Modality Therapy; Controlled Clinical Trials as Topic; Female; Humans; Laser Therapy; Male; Orthodontic Appliances; Piperidines; Polysomnography; Prognosis; Sleep Apnea Syndromes; Thiazoles; Treatment Outcome | 1998 |
Neuroprotective therapy.
Topics: Brain Ischemia; Calcium Channel Blockers; Clinical Trials as Topic; Cytoprotection; Excitatory Amino Acid Antagonists; Humans; Neuroprotective Agents; Piperidines; Thiazoles | 1998 |
Drugs preventing Na+ and Ca2+ overload.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzothiazoles; Calcium; Calcium Channel Blockers; Guanidines; Heart; Homeostasis; Humans; Piperidines; Sodium; Sodium Channel Blockers; Sodium Channels; Sodium-Hydrogen Exchangers; Sulfones; Thiazoles; Thiazolidines | 1999 |
Pharmacologic therapy for type 2 diabetes mellitus.
Topics: Acarbose; Administration, Oral; Algorithms; Carbamates; Chromans; Diabetes Mellitus, Type 2; Evidence-Based Medicine; Humans; Hypoglycemic Agents; Insulin; Metformin; Piperidines; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Trisaccharides; Troglitazone | 1999 |
The use of insulin secretagogues in the treatment of type 2 diabetes.
Topics: Acarbose; Carbamates; Chromans; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Metformin; Peptide Fragments; Piperidines; Protein Precursors; Risk Factors; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
New drugs for diabetes.
Topics: Carbamates; Chromans; Cyclohexanes; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin Resistance; Metformin; Nateglinide; Phenylalanine; Piperidines; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
New directions in type 2 diabetes mellitus: an update of current oral antidiabetic therapy.
Topics: Carbamates; Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Piperidines; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
New agents for Type 2 diabetes.
Topics: Anti-Obesity Agents; Carbamates; Chromans; Diabetes Mellitus, Type 2; Drug Design; Humans; Hypoglycemic Agents; Insulin Resistance; Piperidines; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Clinical efficacy of new thiazolidinediones and glinides in the treatment of type 2 diabetes mellitus.
Topics: Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Nateglinide; Phenylalanine; Pioglitazone; Piperidines; Rosiglitazone; Thiazoles; Thiazolidinediones | 2000 |
An overview of acute stroke therapy: past, present, and future.
Topics: Acute Disease; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Antibodies; Brain Ischemia; Calcium Channel Blockers; Cardiovascular Agents; Cell Adhesion Molecules; Clinical Trials as Topic; Cytidine Diphosphate Choline; Cytokines; Drug Therapy, Combination; Fibrinolytic Agents; Free Radical Scavengers; gamma-Aminobutyric Acid; Growth Substances; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; N-Methylaspartate; Neuroprotective Agents; Nootropic Agents; Piperidines; Stroke; Thiazoles; Thrombolytic Therapy | 2000 |
Therapeutic strategies in Alzheimer's disease: M1 muscarinic agonists.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Carbamates; Cheirogaleidae; Disease Models, Animal; Humans; Muscarinic Agonists; Neuroprotective Agents; Phenylcarbamates; Piperidines; Receptor, Muscarinic M1; Receptors, Muscarinic; Rivastigmine; Signal Transduction; tau Proteins; Thiazoles | 2000 |
Recent advances in the pharmacologic management of diabetes mellitus.
Topics: Acarbose; Administration, Oral; Carbamates; Chromans; Diabetes Mellitus; Drug Overdose; Emergencies; Humans; Hypoglycemic Agents; Insulin; Insulin Lispro; Metformin; Piperidines; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Combination therapy in type 2 diabetes: the role of repaglinide.
Topics: Carbamates; Chromans; Diabetes Mellitus, Type 2; Drug Synergism; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin, Isophane; Metformin; Piperidines; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
[Objectives and therapeutic strategy in type 2 diabetes mellitus].
Topics: Carbamates; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Humans; Hyperinsulinism; Hypoglycemic Agents; Insulin Resistance; Piperidines; Thiazoles | 2001 |
[News in oral antidiabetic therapy].
Topics: Administration, Oral; Carbamates; Diabetes Mellitus; Humans; Hypoglycemic Agents; Pioglitazone; Piperidines; Rosiglitazone; Thiazoles; Thiazolidinediones | 2001 |
Oral antihyperglycemic therapy for type 2 diabetes: scientific review.
Topics: Administration, Oral; Biguanides; Blood Glucose; Carbamates; Chromans; Diabetes Mellitus, Type 2; Diet; Drug Therapy, Combination; Enzyme Inhibitors; Exercise; Glycated Hemoglobin; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Metformin; Piperidines; Randomized Controlled Trials as Topic; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Lubeluzole for acute ischaemic stroke.
Topics: Acute Disease; Brain Ischemia; Humans; Neuroprotective Agents; Piperidines; Thiazoles | 2002 |
Type 2 diabetes management: a comprehensive clinical review of oral medications.
Topics: Benzamides; Carbamates; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Metformin; Piperidines; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones | 2002 |
Advances in atypical antipsychotics for the treatment of schizophrenia: new formulations and new agents.
Topics: Antipsychotic Agents; Aripiprazole; Benzodiazepines; Clinical Trials as Topic; Clozapine; Dosage Forms; Humans; Isoxazoles; Olanzapine; Piperazines; Piperidines; Pirenzepine; Quinolones; Risperidone; Schizophrenia; Thiazoles | 2002 |
[Insulin analogs and new oral antidiabetic drugs].
Topics: Administration, Oral; Carbamates; Cyclohexanes; Diabetes Mellitus; Dose-Response Relationship, Drug; Glucose; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Nateglinide; Phenylalanine; Piperidines; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors | 1999 |
Neuroprotective agents in acute ischemic stroke.
Topics: Acute Disease; Adult; Aged; Animals; Antioxidants; Calcium Channel Blockers; Chlormethiazole; Clinical Trials as Topic; Clinical Trials, Phase III as Topic; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Forecasting; GABA Modulators; Guanidines; Humans; Imidazoles; Middle Aged; Naltrexone; Narcotic Antagonists; Neuroprotective Agents; Pipecolic Acids; Piperidines; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; Stroke; Thiazoles | 2002 |
Nitrous oxide modulator: lubeluzole.
Topics: Aged; Brain Ischemia; Humans; Neuroprotective Agents; Nitrous Oxide; Piperidines; Stroke; Thiazoles | 2002 |
Repaglinide in combination therapy.
Topics: Carbamates; Chromans; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin; Metformin; Pioglitazone; Piperidines; Postprandial Period; Rosiglitazone; Thiazoles; Thiazolidinediones; Treatment Outcome; Troglitazone | 2002 |
Alternatives to lithium and divalproex in the maintenance treatment of bipolar disorder.
Topics: Acetates; Amines; Anticonvulsants; Antimanic Agents; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Calcium Channel Blockers; Carbamazepine; Clozapine; Cyclohexanecarboxylic Acids; Dibenzothiazepines; Donepezil; Fatty Acids, Omega-3; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Indans; Lamotrigine; Lithium Carbonate; Olanzapine; Piperazines; Piperidines; Pirenzepine; Quetiapine Fumarate; Risperidone; Thiazoles; Topiramate; Treatment Outcome; Triazines; Valproic Acid | 2003 |
M1 muscarinic agonists can modulate some of the hallmarks in Alzheimer's disease: implications in future therapy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cell Death; Disease Models, Animal; Down-Regulation; Humans; Memory Disorders; Mice; Muscarinic Agonists; Oxidative Stress; Piperidines; Quinuclidines; Receptor, Muscarinic M1; Spiro Compounds; tau Proteins; Thiazoles; Thiophenes | 2003 |
Neuropharmacological profile of an atypical antipsychotic, NRA0562.
Topics: Animals; Antipsychotic Agents; Brain; Dopamine Antagonists; Humans; Methamphetamine; Motor Activity; Neuropharmacology; Piperidines; Receptors, Dopamine; Schizophrenia; Serotonin Antagonists; Thiazoles | 2003 |
Drugging cell cycle kinases in cancer therapy.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Binding Sites; Cyclin-Dependent Kinases; Flavonoids; Humans; Neoplasms; Oxazoles; Piperidines; Protein Kinase Inhibitors; Purines; Roscovitine; Staurosporine; Sulfonamides; Thiazoles | 2005 |
Neuroprotection and thrombolysis: combination therapy in acute ischaemic stroke.
Topics: Animals; Benzenesulfonates; Brain; Brain Ischemia; Drug Therapy, Combination; Fibrinolytic Agents; Free Radical Scavengers; GABA Agonists; Humans; Neuroprotective Agents; Nitrogen Oxides; Piperidines; Randomized Controlled Trials as Topic; Sodium Channel Blockers; Stroke; Thiazoles; Thrombolytic Therapy; Time Factors; Tissue Plasminogen Activator | 2006 |
[Introduction to and general remarks on molecular imaging].
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Benzoxazoles; Brain; Carbon Radioisotopes; Diagnostic Imaging; Humans; Mice; Molecular Probes; Piperidines; Plaque, Amyloid; Positron-Emission Tomography; Propionates; Thiazoles | 2007 |
Potential ethnic modifiers in the assessment and treatment of Alzheimer's disease: challenges for the future.
Topics: Aged; Alzheimer Disease; Cross-Cultural Comparison; Donepezil; Ethnicity; Galantamine; Humans; Indans; Nootropic Agents; Phenylcarbamates; Piperidines; Randomized Controlled Trials as Topic; Rivastigmine; Thiazoles; White People | 2007 |
M1 muscarinic agonists target major hallmarks of Alzheimer's disease--an update.
Topics: Alzheimer Disease; Animals; Humans; Muscarinic Agonists; Piperidines; Receptor, Muscarinic M1; Spiro Compounds; Thiazoles | 2007 |
[Gastrointestinal stromal tumors: molecular aspects and therapeutic implications].
Topics: Antineoplastic Agents; Benzamides; Benzenesulfonates; Disease Progression; Drug Resistance, Neoplasm; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Indoles; Mutation; Neoplasm Proteins; Niacinamide; Oligonucleotides; Phenylurea Compounds; Phthalazines; Piperazines; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyridines; Pyrimidines; Pyrroles; Receptor, Platelet-Derived Growth Factor alpha; Sorafenib; Staurosporine; Sunitinib; Thiazoles | 2008 |
Akathisia and second-generation antipsychotic drugs.
Topics: Amisulpride; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Clozapine; Dibenzothiazepines; Humans; Isoxazoles; Olanzapine; Piperazines; Piperidines; Prevalence; Psychomotor Agitation; Psychotic Disorders; Quetiapine Fumarate; Quinolones; Risk Factors; Risperidone; Sulpiride; Thiazoles | 2009 |
[Focus on GIST management].
Topics: Antineoplastic Agents; Benzamides; Benzenesulfonates; Chemotherapy, Adjuvant; Drug Resistance, Neoplasm; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Indoles; Niacinamide; Phenylurea Compounds; Piperazines; Piperidines; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Pyrroles; Sorafenib; Sunitinib; Thiazoles | 2010 |
Stratified medicine in selecting biologics for the treatment of severe asthma.
Topics: Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Asthma; Benzamides; Biological Products; Daclizumab; Humans; Immunoglobulin G; Omalizumab; Piperidines; Pyridines; Receptors, Interleukin-4; Thiazoles; Treatment Outcome; Tumor Necrosis Factor-alpha | 2011 |
Iloperidone, asenapine, and lurasidone: a brief overview of 3 new second-generation antipsychotics.
Topics: Akathisia, Drug-Induced; Antipsychotic Agents; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Isoindoles; Isoxazoles; Lurasidone Hydrochloride; Piperidines; Schizophrenia; Thiazoles | 2011 |
Systemic therapy for advanced gastrointestinal stromal tumors: beyond imatinib.
Topics: Antineoplastic Agents; Benzamides; Gastrointestinal Neoplasms; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Indoles; Mutation; Piperazines; Piperidines; Proto-Oncogene Proteins c-kit; Pyridines; Pyrimidines; Pyrroles; Receptors, Platelet-Derived Growth Factor; Sunitinib; Thiazoles | 2011 |
Hematopoietic prostaglandin D synthase inhibitors.
Topics: Alzheimer Disease; Animals; Asthma; Dermatitis, Atopic; Drug Design; Enzyme Inhibitors; Humans; Intramolecular Oxidoreductases; Leukodystrophy, Globoid Cell; Lipocalins; Muscular Dystrophies; Niacinamide; Piperidines; Pulmonary Disease, Chronic Obstructive; Pyrazoles; Pyrimidines; Rhinitis, Allergic, Perennial; Spinal Cord Injuries; Thiazoles | 2012 |
Iloperidone, asenapine and lurasidone: a primer on their current status.
Topics: Adult; Animals; Antipsychotic Agents; Bipolar Disorder; Dibenzocycloheptenes; Drug Approval; Heterocyclic Compounds, 4 or More Rings; Humans; Isoindoles; Isoxazoles; Lurasidone Hydrochloride; Piperidines; Schizophrenia; Thiazoles; United States; United States Food and Drug Administration | 2012 |
Receptor tyrosine kinase inhibitors: molecularly targeted drugs for veterinary cancer therapy.
Topics: Animals; Antineoplastic Agents; Benzamides; Drug Therapy, Combination; Humans; Indoles; Neoplasms; Piperidines; Pyridines; Pyrroles; Receptor Protein-Tyrosine Kinases; Thiazoles | 2012 |
Body weight and metabolic adverse effects of asenapine, iloperidone, lurasidone and paliperidone in the treatment of schizophrenia and bipolar disorder: a systematic review and exploratory meta-analysis.
Topics: Antipsychotic Agents; Bipolar Disorder; Blood Glucose; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Humans; Isoindoles; Isoxazoles; Lipid Metabolism; Lurasidone Hydrochloride; Paliperidone Palmitate; Piperidines; Pyrimidines; Randomized Controlled Trials as Topic; Schizophrenia; Thiazoles; Weight Gain | 2012 |
Asenapine, iloperidone and lurasidone: critical appraisal of the most recently approved pharmacotherapies for schizophrenia in adults.
Topics: Antipsychotic Agents; Dibenzocycloheptenes; Drug Approval; Heterocyclic Compounds, 4 or More Rings; Humans; Isoindoles; Isoxazoles; Lurasidone Hydrochloride; Piperidines; Schizophrenia; Thiazoles | 2013 |
Newer antipsychotics and upcoming molecules for schizophrenia.
Topics: Antipsychotic Agents; Dibenzocycloheptenes; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Isoindoles; Isoxazoles; Lurasidone Hydrochloride; Piperazines; Piperidines; Schizophrenia; Thiazoles | 2013 |
[Pigmentary disorders induced by anticancer agents. Part II: targeted therapies].
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Benzamides; Cetuximab; Dasatinib; ErbB Receptors; Humans; Imatinib Mesylate; Indazoles; Indoles; Ipilimumab; Niacinamide; Phenylurea Compounds; Pigmentation Disorders; Piperazines; Piperidines; Programmed Cell Death 1 Receptor; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Quinazolines; Receptors, Vascular Endothelial Growth Factor; Sorafenib; Sulfonamides; Sunitinib; Thiazoles | 2013 |
Dual orexin receptor antagonists - promising agents in the treatment of sleep disorders.
Topics: Acetamides; Animals; Azepines; Benzofurans; Humans; Isoquinolines; Models, Biological; Orexin Receptor Antagonists; Orexin Receptors; Piperidines; Pyrimidines; Sleep; Sleep Initiation and Maintenance Disorders; Thiazoles; Triazoles; Wakefulness | 2014 |
Novel agents for multiple myeloma to overcome resistance in phase III clinical trials.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Benzamides; Clinical Trials, Phase III as Topic; Disease-Free Survival; Drug Resistance, Neoplasm; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Immunologic Factors; Indoles; Multiple Myeloma; Oligopeptides; Panobinostat; Phosphorylcholine; Piperidines; Proteasome Inhibitors; Pyridines; Remission Induction; Thalidomide; Thiazoles; Treatment Outcome; Vorinostat | 2013 |
Orexin in sleep, addiction and more: is the perfect insomnia drug at hand?
Topics: Acetamides; Animals; Azepines; Behavior, Addictive; Benzofurans; Feeding Behavior; Humans; Intracellular Signaling Peptides and Proteins; Isoquinolines; Mice; Neuropeptides; Orexin Receptor Antagonists; Orexin Receptors; Orexins; Piperidines; Pyrimidines; Rats; Reward; Sleep; Sleep Initiation and Maintenance Disorders; Thiazoles; Triazoles | 2013 |
Masitinib (AB1010), from canine tumor model to human clinical development: where we are?
Topics: Animals; Benzamides; Dogs; Humans; Neoplasms, Experimental; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Mas; Pyridines; Structure-Activity Relationship; Thiazoles | 2014 |
Cardiometabolic risks of blonanserin and perospirone in the management of schizophrenia: a systematic review and meta-analysis of randomized controlled trials.
Topics: Adult; Antipsychotic Agents; Blood Glucose; Double-Blind Method; Glycated Hemoglobin; Heart; Humans; Isoindoles; Piperazines; Piperidines; Randomized Controlled Trials as Topic; Risk; Schizophrenia; Thiazoles; Weight Gain | 2014 |
Treating the violent patient with psychosis or impulsivity utilizing antipsychotic polypharmacy and high-dose monotherapy.
Topics: Antipsychotic Agents; Aripiprazole; Benzodiazepines; Brain; Clozapine; Dibenzocycloheptenes; Drug Therapy, Combination; Heterocyclic Compounds, 4 or More Rings; Humans; Impulsive Behavior; Isoxazoles; Lurasidone Hydrochloride; Olanzapine; Paliperidone Palmitate; Piperazines; Piperidines; Polypharmacy; Psychotic Disorders; Quetiapine Fumarate; Receptors, Dopamine D2; Risperidone; Thiazoles; Violence | 2014 |
Small molecule inhibitors in veterinary oncology practice.
Topics: Animals; Benzamides; Cat Diseases; Cats; Dog Diseases; Dogs; Indoles; Neoplasms; Piperidines; Protein Kinase Inhibitors; Pyridines; Pyrroles; Thiazoles | 2014 |
Masitinib for the treatment of mild to moderate Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Benzamides; Humans; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyridines; Thiazoles | 2015 |
A systematic review of drugs in late-stage development for the treatment of multiple sclerosis: a focus on oral synthetic drugs.
Topics: Benzamides; Humans; Immunologic Factors; Multiple Sclerosis; Piperidines; Pyridines; Quinolones; Small Molecule Libraries; Thiazoles | 2015 |
Targeting mast cells in gastric cancer with special reference to bone metastases.
Topics: Animals; Antigens, CD34; Benzamides; Benzamidines; Bone and Bones; Bone Neoplasms; Bone Resorption; Disease Progression; Gabexate; Guanidines; Humans; Imatinib Mesylate; Immune System; Mast Cells; Neovascularization, Pathologic; NF-kappa B; Piperidines; Proto-Oncogene Proteins c-kit; Pyridines; Stomach Neoplasms; Thiazoles; Tryptases | 2015 |
Overview of CDK9 as a target in cancer research.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Cell Cycle; Cyclic N-Oxides; Cyclin-Dependent Kinase 9; Flavonoids; Humans; Indolizines; Molecular Targeted Therapy; Neoplasms; Oxazoles; Piperidines; Protein Kinase Inhibitors; Purines; Pyrazoles; Pyridinium Compounds; Roscovitine; Thiazoles; Urea | 2016 |
Current Research Therapeutic Strategies for Alzheimer's Disease Treatment.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzamides; Benzodioxoles; Brain; Disease Models, Animal; Humans; Mice; Neurons; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-fyn; PrPC Proteins; Pyridines; Quinazolines; Receptor, Metabotropic Glutamate 5; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Synapses; Thiazoles | 2016 |
Novel Oral Therapies for Psoriasis and Psoriatic Arthritis.
Topics: Adamantane; Adenosine; Adenosine A3 Receptor Antagonists; Administration, Oral; Arthritis, Psoriatic; Azetidines; Biological Factors; Biological Therapy; Clinical Trials as Topic; Humans; Isonicotinic Acids; Janus Kinases; Niacinamide; Phosphodiesterase 4 Inhibitors; Piperidines; Protein Kinase Inhibitors; Psoriasis; Purines; Pyrazoles; Pyrimidines; Pyrroles; Receptors, Lysosphingolipid; rho-Associated Kinases; Sulfonamides; Thalidomide; Thiazoles | 2016 |
Gemcitabine mono-therapy versus gemcitabine plus targeted therapy in advanced pancreatic cancer: a meta-analysis of randomized phase III trials.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Clinical Trials, Phase III as Topic; Deoxycytidine; Disease Progression; Gemcitabine; Humans; Molecular Targeted Therapy; Pancreatic Neoplasms; Piperidines; Pyridines; Randomized Controlled Trials as Topic; Survival Analysis; Thiazoles | 2017 |
Can binimetinib, encorafenib and masitinib be more efficacious than currently available mutation-based targeted therapies for melanoma treatment?
Topics: Benzamides; Benzimidazoles; Carbamates; Humans; Melanoma; Mutation; Piperidines; Protein Kinase Inhibitors; Proteomics; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-kit; Pyridines; Skin Neoplasms; Sulfonamides; Thiazoles | 2017 |
Evidence-Based Review of Pharmacotherapy Used for Parkinson's Disease Psychosis.
Topics: Antipsychotic Agents; Benzodiazepines; Clozapine; Evidence-Based Medicine; Humans; Olanzapine; Parkinson Disease; Piperazines; Piperidines; Practice Guidelines as Topic; Psychotic Disorders; Quetiapine Fumarate; Randomized Controlled Trials as Topic; Risperidone; Thiazoles; Urea | 2017 |
Effects of Benzothiazolamines on Voltage-Gated Sodium Channels.
Topics: Animals; Humans; Myotonia; Piperidines; Riluzole; Thiazoles; Voltage-Gated Sodium Channels | 2018 |
Oral small molecules for psoriasis.
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Humans; Patient Selection; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrimidines; Pyrroles; Thalidomide; Thiazoles | 2018 |
An evaluation of masitinib for treating systemic mastocytosis.
Topics: Benzamides; Humans; Imatinib Mesylate; Mast Cells; Mastocytosis, Systemic; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyridines; Thiazoles | 2019 |
Dose-Response Meta-Analysis of Antipsychotic Drugs for Acute Schizophrenia.
Topics: Acute Disease; Administration, Oral; Antipsychotic Agents; Aripiprazole; Clozapine; Delayed-Action Preparations; Dose-Response Relationship, Drug; Haloperidol; Humans; Imidazoles; Indoles; Isoxazoles; Lurasidone Hydrochloride; Olanzapine; Paliperidone Palmitate; Piperazines; Piperidines; Quetiapine Fumarate; Quinolones; Risperidone; Schizophrenia; Schizophrenic Psychology; Thiazoles; Thiophenes | 2020 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor Proteins, Signal Transducing; Adenine; Adenocarcinoma; Adipogenesis; Administration, Cutaneous; Administration, Ophthalmic; Adolescent; Adsorption; Adult; Aeromonas hydrophila; Aerosols; Aged; Aged, 80 and over; Aging; Agriculture; Air Pollutants; Air Pollution; Airway Remodeling; Alanine Transaminase; Albuminuria; Aldehyde Dehydrogenase 1 Family; Algorithms; AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase; Alzheimer Disease; Amino Acid Sequence; Ammonia; Ammonium Compounds; Anaerobiosis; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Antibodies, Antineutrophil Cytoplasmic; Antibodies, Monoclonal, Humanized; Antifungal Agents; Antigens, Bacterial; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antitubercular Agents; Antiviral Agents; Apolipoproteins E; Apoptosis; Arabidopsis; Arabidopsis Proteins; Arsenic; Arthritis, Rheumatoid; Asthma; Atherosclerosis; ATP-Dependent Proteases; Attitude of Health Personnel; Australia; Austria; Autophagy; Axitinib; Bacteria; Bacterial Outer Membrane Proteins; Bacterial Proteins; Bacterial Toxins; Bacterial Typing Techniques; Bariatric Surgery; Base Composition; Bayes Theorem; Benzoxazoles; Benzylamines; beta Catenin; Betacoronavirus; Betula; Binding Sites; Biological Availability; Biological Oxygen Demand Analysis; Biomarkers; Biomarkers, Tumor; Biopsy; Bioreactors; Biosensing Techniques; Birth Weight; Blindness; Blood Chemical Analysis; Blood Gas Analysis; Blood Glucose; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Blood-Brain Barrier; Blotting, Western; Body Mass Index; Body Weight; Bone and Bones; Bone Density; Bone Resorption; Borates; Brain; Brain Infarction; Brain Injuries, Traumatic; Brain Neoplasms; Breakfast; Breast Milk Expression; Breast Neoplasms; Bronchi; Bronchoalveolar Lavage Fluid; Buffaloes; Cadherins; Calcification, Physiologic; Calcium Compounds; Calcium, Dietary; Cannula; Caprolactam; Carbon; Carbon Dioxide; Carboplatin; Carcinogenesis; Carcinoma, Ductal; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Cardiovascular Diseases; Carps; Carrageenan; Case-Control Studies; Catalysis; Catalytic Domain; Cattle; CD8-Positive T-Lymphocytes; Cell Adhesion; Cell Cycle Proteins; Cell Death; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Phone Use; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Cellulose; Chemical Phenomena; Chemoradiotherapy; Child; Child Development; Child, Preschool; China; Chitosan; Chlorocebus aethiops; Cholecalciferol; Chromatography, Liquid; Circadian Clocks; Circadian Rhythm; Circular Dichroism; Cisplatin; Citric Acid; Clinical Competence; Clinical Laboratory Techniques; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clostridioides difficile; Clostridium Infections; Coculture Techniques; Cohort Studies; Cold Temperature; Colitis; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type XI; Color; Connective Tissue Diseases; Copper; Coronary Angiography; Coronavirus 3C Proteases; Coronavirus Infections; Cost of Illness; Counselors; COVID-19; COVID-19 Testing; Creatine Kinase; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Cryoelectron Microscopy; Cryosurgery; Crystallography, X-Ray; Cues; Cultural Competency; Cultural Diversity; Curriculum; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase Inhibitor p21; Cycloparaffins; Cysteine Endopeptidases; Cytokines; Cytoplasm; Cytoprotection; Databases, Factual; Denitrification; Deoxycytidine; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diagnosis, Differential; Diatoms; Diet; Diet, High-Fat; Dietary Exposure; Diffusion Magnetic Resonance Imaging; Diketopiperazines; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Disease Progression; Disease-Free Survival; DNA; DNA Damage; DNA Glycosylases; DNA Repair; DNA-Binding Proteins; DNA, Bacterial; DNA, Viral; Docetaxel; Dose Fractionation, Radiation; Dose-Response Relationship, Drug; Down-Regulation; Doxorubicin; Drosophila; Drosophila melanogaster; Drug Carriers; Drug Delivery Systems; Drug Liberation; Drug Repositioning; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Drug Therapy, Combination; Edema; Edible Grain; Education, Graduate; Education, Medical, Graduate; Education, Pharmacy; Ehlers-Danlos Syndrome; Electron Transport Complex III; Electron Transport Complex IV; Electronic Nicotine Delivery Systems; Emergency Service, Hospital; Empathy; Emulsions; Endothelial Cells; Endurance Training; Energy Intake; Enterovirus A, Human; Environment; Environmental Monitoring; Enzyme Assays; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Epoxide Hydrolases; Epoxy Compounds; Erythrocyte Count; Erythrocytes; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Esophagectomy; Estrogens; Etanercept; Ethiopia; Ethnicity; Ethylenes; Exanthema; Exercise; Exercise Test; Exercise Tolerance; Extracellular Matrix; Extracorporeal Membrane Oxygenation; Eye Infections, Fungal; False Negative Reactions; Fatty Acids; Fecal Microbiota Transplantation; Feces; Female; Femur Neck; Fermentation; Ferritins; Fetal Development; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Fibroblasts; Fibroins; Fish Proteins; Flavanones; Flavonoids; Focus Groups; Follow-Up Studies; Food Handling; Food Supply; Food, Formulated; Forced Expiratory Volume; Forests; Fractures, Bone; Fruit and Vegetable Juices; Fusobacteria; G1 Phase Cell Cycle Checkpoints; G2 Phase Cell Cycle Checkpoints; Gamma Rays; Gastrectomy; Gastrointestinal Microbiome; Gastrointestinal Stromal Tumors; Gefitinib; Gels; Gemcitabine; Gene Amplification; Gene Expression; Gene Expression Regulation; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Plant; Gene Knockdown Techniques; Gene-Environment Interaction; Genotype; Germany; Glioma; Glomerular Filtration Rate; Glucagon; Glucocorticoids; Glycemic Control; Glycerol; Glycogen Synthase Kinase 3 beta; Glycolipids; Glycolysis; Goblet Cells; Gram-Negative Bacterial Infections; Granulocyte Colony-Stimulating Factor; Graphite; Greenhouse Effect; Guanidines; Haemophilus influenzae; HCT116 Cells; Health Knowledge, Attitudes, Practice; Health Personnel; Health Services Accessibility; Health Services Needs and Demand; Health Status Disparities; Healthy Volunteers; Heart Failure; Heart Rate; Heart Transplantation; Heart-Assist Devices; HEK293 Cells; Heme; Heme Oxygenase-1; Hemolysis; Hemorrhage; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hepatocytes; Hexoses; High-Throughput Nucleotide Sequencing; Hippo Signaling Pathway; Histamine; Histamine Agonists; Histidine; Histone Deacetylase 2; HIV Infections; HIV Reverse Transcriptase; HIV-1; Homebound Persons; Homeodomain Proteins; Homosexuality, Male; Hospice and Palliative Care Nursing; HSP70 Heat-Shock Proteins; Humans; Hyaluronan Receptors; Hydrogen; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrolysis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemia; Hypoglycemic Agents; Hypoxia; Idiopathic Interstitial Pneumonias; Imaging, Three-Dimensional; Imatinib Mesylate; Immunotherapy; Implementation Science; Incidence; INDEL Mutation; Induced Pluripotent Stem Cells; Industrial Waste; Infant; Infant, Newborn; Inflammation; Inflammation Mediators; Infliximab; Infusions, Intravenous; Inhibitory Concentration 50; Injections; Insecticides; Insulin-Like Growth Factor Binding Protein 5; Insulin-Secreting Cells; Interleukin-1; Interleukin-17; Interleukin-8; Internship and Residency; Intestines; Intracellular Signaling Peptides and Proteins; Ion Transport; Iridaceae; Iridoid Glucosides; Islets of Langerhans Transplantation; Isodon; Isoflurane; Isotopes; Italy; Joint Instability; Ketamine; Kidney; Kidney Failure, Chronic; Kidney Function Tests; Kidney Neoplasms; Kinetics; Klebsiella pneumoniae; Knee Joint; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Lactate Dehydrogenase 5; Laparoscopy; Laser Therapy; Lasers, Semiconductor; Lasers, Solid-State; Laurates; Lead; Leukocyte L1 Antigen Complex; Leukocytes, Mononuclear; Light; Lipid Peroxidation; Lipopolysaccharides; Liposomes; Liver; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Locomotion; Longitudinal Studies; Lopinavir; Lower Urinary Tract Symptoms; Lubricants; Lung; Lung Diseases, Interstitial; Lung Neoplasms; Lymphocyte Activation; Lymphocytes, Tumor-Infiltrating; Lymphoma, Mantle-Cell; Lysosomes; Macrophages; Male; Manganese Compounds; MAP Kinase Kinase 4; Mass Screening; Maternal Health; Medicine, Chinese Traditional; Melanoma, Experimental; Memantine; Membrane Glycoproteins; Membrane Proteins; Mesenchymal Stem Cell Transplantation; Metal Nanoparticles; Metalloendopeptidases; Metalloporphyrins; Methadone; Methane; Methicillin-Resistant Staphylococcus aureus; Mexico; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Mice, Nude; Mice, SCID; Mice, Transgenic; Microarray Analysis; Microbial Sensitivity Tests; Microbiota; Micronutrients; MicroRNAs; Microscopy, Confocal; Microsomes, Liver; Middle Aged; Milk; Milk, Human; Minority Groups; Mitochondria; Mitochondrial Membranes; Mitochondrial Proteins; Models, Animal; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Epidemiology; Molecular Structure; Molecular Weight; Multilocus Sequence Typing; Multimodal Imaging; Muscle Strength; Muscle, Skeletal; Muscular Diseases; Mutation; Mycobacterium tuberculosis; Myocardial Stunning; Myristates; NAD(P)H Dehydrogenase (Quinone); Nanocomposites; Nanogels; Nanoparticles; Nanotechnology; Naphthalenes; Nasal Cavity; National Health Programs; Necrosis; Needs Assessment; Neoadjuvant Therapy; Neonicotinoids; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasm Transplantation; Neoplasms; Neoplastic Stem Cells; Netherlands; Neuroblastoma; Neuroprotective Agents; Neutrophils; NF-kappa B; NFATC Transcription Factors; Nicotiana; Nicotine; Nitrates; Nitrification; Nitrites; Nitro Compounds; Nitrogen; Nitrogen Dioxide; North Carolina; Nuclear Magnetic Resonance, Biomolecular; Nuclear Proteins; Nucleic Acid Hybridization; Nucleosomes; Nutrients; Obesity; Obesity, Morbid; Oceans and Seas; Oncogene Protein v-akt; Oncogenes; Oocytes; Open Reading Frames; Osteoclasts; Osteogenesis; Osteoporosis; Osteoporosis, Postmenopausal; Outpatients; Ovarian Neoplasms; Ovariectomy; Overweight; Oxazines; Oxidants; Oxidation-Reduction; Oxidative Stress; Oxides; Oxidoreductases; Oxygen; Oxygen Inhalation Therapy; Oxygenators, Membrane; Ozone; Paclitaxel; Paenibacillus; Pain Measurement; Palliative Care; Pancreatic Neoplasms; Pandemics; Parasympathetic Nervous System; Particulate Matter; Pasteurization; Patient Preference; Patient Satisfaction; Pediatric Obesity; Permeability; Peroxiredoxins; Peroxynitrous Acid; Pharmaceutical Services; Pharmacists; Pharmacy; Phaseolus; Phenotype; Phoeniceae; Phosphates; Phosphatidylinositol 3-Kinases; Phospholipid Transfer Proteins; Phospholipids; Phosphorus; Phosphorylation; Photoperiod; Photosynthesis; Phylogeny; Physical Endurance; Physicians; Pilot Projects; Piperidines; Pituitary Adenylate Cyclase-Activating Polypeptide; Plant Extracts; Plant Leaves; Plant Proteins; Plant Roots; Plaque, Atherosclerotic; Pneumonia; Pneumonia, Viral; Point-of-Care Testing; Polyethylene Glycols; Polymers; Polysorbates; Pore Forming Cytotoxic Proteins; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Postprandial Period; Poverty; Pre-Exposure Prophylaxis; Prediabetic State; Predictive Value of Tests; Pregnancy; Pregnancy Trimester, First; Pregnancy, High-Risk; Prenatal Exposure Delayed Effects; Pressure; Prevalence; Primary Graft Dysfunction; Primary Health Care; Professional Role; Professionalism; Prognosis; Progression-Free Survival; Prolactin; Promoter Regions, Genetic; Proof of Concept Study; Proportional Hazards Models; Propylene Glycol; Prospective Studies; Prostate; Protein Binding; Protein Biosynthesis; Protein Isoforms; Protein Kinase Inhibitors; Protein Phosphatase 2; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein Transport; Proteoglycans; Proteome; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins c-ret; Proto-Oncogene Proteins p21(ras); Proton Pumps; Protons; Protoporphyrins; Pseudomonas aeruginosa; Pseudomonas fluorescens; Pulmonary Artery; Pulmonary Disease, Chronic Obstructive; Pulmonary Gas Exchange; Pulmonary Veins; Pyrazoles; Pyridines; Pyrimidines; Qualitative Research; Quinoxalines; Rabbits; Random Allocation; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Histamine H3; Receptors, Immunologic; Receptors, Transferrin; Recombinant Proteins; Recurrence; Reference Values; Referral and Consultation; Regional Blood Flow; Registries; Regulon; Renal Insufficiency, Chronic; Reperfusion Injury; Repressor Proteins; Reproducibility of Results; Republic of Korea; Research Design; Resistance Training; Respiration, Artificial; Respiratory Distress Syndrome; Respiratory Insufficiency; Resuscitation; Retinal Dehydrogenase; Retreatment; Retrospective Studies; Reverse Transcriptase Inhibitors; Rhinitis, Allergic; Ribosomal Proteins; Ribosomes; Risk Assessment; Risk Factors; Ritonavir; Rivers; RNA Interference; RNA-Seq; RNA, Messenger; RNA, Ribosomal, 16S; RNA, Small Interfering; Rosuvastatin Calcium; Rural Population; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salivary Ducts; Salivary Gland Neoplasms; San Francisco; SARS-CoV-2; Satiation; Satiety Response; Schools; Schools, Pharmacy; Seasons; Seawater; Selection, Genetic; Sequence Analysis, DNA; Serine-Threonine Kinase 3; Sewage; Sheep; Sheep, Domestic; Shock, Hemorrhagic; Signal Transduction; Silver; Silymarin; Single Photon Emission Computed Tomography Computed Tomography; Sirolimus; Sirtuin 1; Skin; Skin Neoplasms; Skin Physiological Phenomena; Sleep Initiation and Maintenance Disorders; Social Class; Social Participation; Social Support; Soil; Soil Microbiology; Solutions; Somatomedins; Soot; Specimen Handling; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis; Spinal Fractures; Spirometry; Staphylococcus aureus; STAT1 Transcription Factor; STAT3 Transcription Factor; Streptomyces coelicolor; Stress, Psychological; Stroke; Stroke Volume; Structure-Activity Relationship; Students, Medical; Students, Pharmacy; Substance Abuse Treatment Centers; Sulfur Dioxide; Surface Properties; Surface-Active Agents; Surveys and Questionnaires; Survival Analysis; Survival Rate; Survivin; Sweden; Swine; Swine, Miniature; Sympathetic Nervous System; T-Lymphocytes, Regulatory; Talaromyces; Tandem Mass Spectrometry; tau Proteins; Telemedicine; Telomerase; Telomere; Telomere Homeostasis; Temperature; Terminally Ill; Th1 Cells; Thiamethoxam; Thiazoles; Thiophenes; Thioredoxin Reductase 1; Thrombosis; Thulium; Thyroid Cancer, Papillary; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Time Factors; Titanium; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transcriptome; Transforming Growth Factor beta1; Transistors, Electronic; Translational Research, Biomedical; Transplantation Tolerance; Transplantation, Homologous; Transportation; Treatment Outcome; Tretinoin; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary; Tubulin Modulators; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Twins; Ultrasonic Therapy; Ultrasonography; Ultraviolet Rays; United States; Up-Regulation; Uranium; Urethra; Urinary Bladder; Urodynamics; Uromodulin; Uveitis; Vasoconstrictor Agents; Ventricular Function, Left; Vero Cells; Vesicular Transport Proteins; Viral Nonstructural Proteins; Visual Acuity; Vital Capacity; Vitamin D; Vitamin D Deficiency; Vitamin K 2; Vitamins; Volatilization; Voriconazole; Waiting Lists; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical; Whole Genome Sequencing; Wine; Wnt Signaling Pathway; Wound Healing; Wounds and Injuries; WW Domains; X-linked Nuclear Protein; X-Ray Diffraction; Xanthines; Xenograft Model Antitumor Assays; YAP-Signaling Proteins; Yogurt; Young Adult; Zebrafish; Zebrafish Proteins; Ziziphus | 2016 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acrylic Resins; Actinobacillus; Acute Disease; Acute Kidney Injury; Adaptor Proteins, Signal Transducing; Adenosine; Adenosine Triphosphate; Administration, Inhalation; Administration, Oral; Adolescent; Adult; Advance Care Planning; Africa, Northern; Age Factors; Aged; Aged, 80 and over; Air Pollutants; Air Pollution; Air Pollution, Indoor; Albendazole; Aluminum Oxide; Anastomosis, Surgical; Ancylostoma; Ancylostomiasis; Androstadienes; Angiogenesis Inhibitors; Angiotensin II; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antibodies, Bispecific; Antibodies, Viral; Anticoagulants; Antihypertensive Agents; Antinematodal Agents; Antineoplastic Agents; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antiporters; Antiviral Agents; Apoptosis; Aptamers, Nucleotide; Aromatase Inhibitors; Asian People; Astrocytes; Atrial Fibrillation; Auditory Threshold; Aurora Kinase B; Australia; Autophagy; Autophagy-Related Protein 5; Autotrophic Processes; Bacillus cereus; Bacillus thuringiensis; Bacterial Proteins; Beclin-1; Belgium; Benzene; Benzene Derivatives; Benzhydryl Compounds; beta Catenin; beta-Arrestin 2; Biliary Tract Diseases; Biofilms; Biofuels; Biomarkers; Biomarkers, Tumor; Biomass; Biomechanical Phenomena; Bioreactors; Biosensing Techniques; Biosynthetic Pathways; Bismuth; Blood Platelets; Bone and Bones; Bone Regeneration; Bortezomib; Botulinum Toxins, Type A; Brain; Brain Injuries; Brain Ischemia; Brain Neoplasms; Breast Neoplasms; Breath Tests; Bronchodilator Agents; Calcium Phosphates; Cannabis; Carbon Dioxide; Carbon Isotopes; Carcinogenesis; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cardiac Resynchronization Therapy; Cardiac Resynchronization Therapy Devices; Cardiomyopathies; Cardiovascular Diseases; Cariostatic Agents; Case Managers; Case-Control Studies; Catalysis; Cation Transport Proteins; CD8-Positive T-Lymphocytes; Cecropia Plant; Cell Adhesion; Cell Count; Cell Differentiation; Cell Division; Cell Line; Cell Line, Tumor; Cell Membrane; Cell Movement; Cell Proliferation; Cell Self Renewal; Cell Survival; Cells, Cultured; Cellular Reprogramming; Cellulose; Charcoal; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemokines; Chemoradiotherapy; Chemoreceptor Cells; Child; Child Abuse; Child, Preschool; China; Chlorogenic Acid; Chloroquine; Chromatography, Gas; Chronic Disease; Clinical Competence; Coated Materials, Biocompatible; Cochlea; Cohort Studies; Color; Comorbidity; Computer Simulation; Computer-Aided Design; Contraception; Contraceptive Agents, Female; Contrast Media; COP-Coated Vesicles; Coronavirus Infections; Cost of Illness; Coturnix; COVID-19; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Culex; Curriculum; Cyclic N-Oxides; Cytokines; Cytoplasm; Cytotoxicity, Immunologic; Cytotoxins; Databases, Factual; Deep Learning; Delivery, Obstetric; Denitrification; Dental Caries; Denture, Complete; Dexamethasone; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dielectric Spectroscopy; Diet, High-Fat; Dietary Fiber; Disease Models, Animal; Disease Progression; DNA; DNA Copy Number Variations; DNA, Mitochondrial; Dog Diseases; Dogs; Dopaminergic Neurons; Double-Blind Method; Down-Regulation; Doxorubicin; Drug Carriers; Drug Design; Drug Interactions; Drug Resistance, Bacterial; Drug Resistance, Neoplasm; Drug-Related Side Effects and Adverse Reactions; Drugs, Chinese Herbal; Dry Powder Inhalers; Dust; E2F1 Transcription Factor; Ecosystem; Education, Nursing; Education, Nursing, Baccalaureate; Electric Impedance; Electricity; Electrocardiography; Electrochemical Techniques; Electrochemistry; Electrodes; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Endothelial Cells; Environmental Monitoring; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Estrogen Receptor Modulators; Europe; Evoked Potentials, Auditory, Brain Stem; Exosomes; Feasibility Studies; Female; Ferricyanides; Ferrocyanides; Fibrinogen; Finite Element Analysis; Fistula; Fluorescent Dyes; Fluorides, Topical; Fluorodeoxyglucose F18; Fluticasone; Follow-Up Studies; Food Contamination; Food Microbiology; Foods, Specialized; Forensic Medicine; Frail Elderly; France; Free Radicals; Fresh Water; Fungi; Fungicides, Industrial; Galactosamine; Gastrointestinal Neoplasms; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Frequency; Genetic Predisposition to Disease; Genotype; Gingival Hemorrhage; Glioblastoma; Glioma; Glomerular Filtration Rate; Glomerulosclerosis, Focal Segmental; Glucose; Glucose Transport Proteins, Facilitative; Glucosides; Glutamine; Glycolysis; Gold; GPI-Linked Proteins; Gram-Negative Bacteria; Gram-Positive Bacteria; Graphite; Haplotypes; HCT116 Cells; Healthy Volunteers; Hearing Loss; Heart Failure; Hedgehog Proteins; HEK293 Cells; HeLa Cells; Hemodynamics; Hemorrhage; Hepatocytes; Hippo Signaling Pathway; Histone Deacetylases; Homeostasis; Hospital Mortality; Hospitalization; Humans; Hydantoins; Hydrazines; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Hydroxylamines; Hypoglycemic Agents; Immunity, Innate; Immunoglobulin G; Immunohistochemistry; Immunologic Factors; Immunomodulation; Immunophenotyping; Immunotherapy; Incidence; Indazoles; Indonesia; Infant; Infant, Newborn; Infarction, Middle Cerebral Artery; Inflammation; Injections, Intramuscular; Insecticides; Insulin-Like Growth Factor I; Insurance, Health; Intention to Treat Analysis; Interleukin-1 Receptor-Associated Kinases; Interleukin-6; Intrauterine Devices; Intrauterine Devices, Copper; Iron; Ischemia; Jordan; Keratinocytes; Kidney; Kidney Diseases; Kir5.1 Channel; Klebsiella Infections; Klebsiella pneumoniae; Lab-On-A-Chip Devices; Laparoscopy; Lasers; Lasers, Semiconductor; Lenalidomide; Leptin; Lethal Dose 50; Levonorgestrel; Limit of Detection; Lipid Metabolism; Lipid Metabolism Disorders; Lipogenesis; Lipopolysaccharides; Liquid Biopsy; Liver; Liver Abscess, Pyogenic; Liver Cirrhosis; Liver Diseases; Liver Neoplasms; Longevity; Lung Neoplasms; Luteolin; Lymph Nodes; Lymphocyte Activation; Macaca fascicularis; Macrophages; Mad2 Proteins; Magnetic Resonance Imaging; Male; Mammary Glands, Human; Manganese; Manganese Compounds; MAP Kinase Signaling System; Materials Testing; Maternal Health Services; MCF-7 Cells; Medicaid; Medicine, Chinese Traditional; Melanoma; Membrane Proteins; Mental Health; Mercury; Metal Nanoparticles; Metals, Heavy; Metformin; Methionine Adenosyltransferase; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Mice, Nude; Microalgae; Microbial Sensitivity Tests; Microglia; MicroRNAs; Microscopy, Atomic Force; Microscopy, Electron, Scanning; Middle Aged; Mitochondria; Mitochondrial Proteins; Mitral Valve; Mitral Valve Insufficiency; Models, Anatomic; Molecular Structure; Molybdenum; Monocarboxylic Acid Transporters; Moths; MPTP Poisoning; Multigene Family; Multiparametric Magnetic Resonance Imaging; Multiple Myeloma; Muscle, Skeletal; Mutagens; Mutation; Myeloid Cells; Nanocomposites; Nanofibers; Nanomedicine; Nanoparticles; Nanowires; Neoadjuvant Therapy; Neomycin; Neoplasm Grading; Neoplasm Recurrence, Local; Neoplasms; Neoplastic Stem Cells; Neostriatum; Neovascularization, Pathologic; Netherlands; Neuromuscular Agents; Neurons; NF-E2-Related Factor 2; NF-kappa B; Nickel; Nitrogen Oxides; Non-alcoholic Fatty Liver Disease; Nucleosides; Nucleotidyltransferases; Nutritional Status; Obesity, Morbid; Ofloxacin; Oils, Volatile; Oligopeptides; Oncogene Protein v-akt; Optical Imaging; Organic Cation Transport Proteins; Organophosphonates; Osteoarthritis; Osteoarthritis, Hip; Osteoarthritis, Knee; Osteoblasts; Osteogenesis; Oxidation-Reduction; Oxidative Stress; Oxides; Oxygen Isotopes; Pancreas; Pancreaticoduodenectomy; Pandemics; Particle Size; Particulate Matter; Patient Acceptance of Health Care; Patient Compliance; PC-3 Cells; Peptide Fragments; Peptides; Periodontal Attachment Loss; Periodontal Index; Periodontal Pocket; Periodontitis; Peroxides; Peru; Pest Control, Biological; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Phylogeny; Pilot Projects; Piperidines; Plant Bark; Plant Extracts; Plant Leaves; Plasmids; Platelet Function Tests; Pneumonia, Viral; Podocytes; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Polyethylene Terephthalates; Polymers; Polymorphism, Single Nucleotide; Porosity; Portugal; Positron-Emission Tomography; Postoperative Complications; Postural Balance; Potassium Channels, Inwardly Rectifying; Povidone; Powders; Precancerous Conditions; Precision Medicine; Predictive Value of Tests; Pregnancy; Prenatal Care; Prognosis; Promoter Regions, Genetic; Prospective Studies; Prostatectomy; Prostatic Neoplasms; Proteasome Inhibitors; Protective Agents; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-akt; Psychiatric Nursing; PTEN Phosphohydrolase; Pulmonary Embolism; Pyrimethamine; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reactive Oxygen Species; Receptor, ErbB-2; Receptor, IGF Type 1; Receptors, Estrogen; Receptors, G-Protein-Coupled; Recombinational DNA Repair; Recovery of Function; Regional Blood Flow; Renal Dialysis; Renin; Renin-Angiotensin System; Reperfusion Injury; Reproducibility of Results; Republic of Korea; Respiratory Distress Syndrome; Retrospective Studies; Rhodamines; Risk Assessment; Risk Factors; RNA, Long Noncoding; RNA, Messenger; Running; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salinity; Salmeterol Xinafoate; Sarcoma; Seasons; Shoulder Injuries; Signal Transduction; Silicon Dioxide; Silver; Sirtuin 1; Sirtuins; Skull Fractures; Social Determinants of Health; Sodium; Sodium Fluoride; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Glucose Transporter 2 Inhibitors; Soil; Soil Pollutants; Spain; Spectrophotometry; Spectroscopy, Fourier Transform Infrared; Staphylococcal Protein A; Staphylococcus aureus; Stem Cells; Stereoisomerism; Stomach Neoplasms; Streptomyces; Strontium; Structure-Activity Relationship; Students, Nursing; Substance-Related Disorders; Succinic Acid; Sulfur; Surface Properties; Survival Rate; Survivin; Symporters; T-Lymphocytes; Temozolomide; Tensile Strength; Thiazoles; Thiobacillus; Thiohydantoins; Thiourea; Thrombectomy; Time Factors; Titanium; Tobacco Mosaic Virus; Tobacco Use Disorder; Toll-Like Receptor 4; Toluene; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Toxicity Tests, Acute; Toxicity Tests, Subacute; Transcriptional Activation; Treatment Outcome; Troponin I; Tumor Cells, Cultured; Tumor Escape; Tumor Hypoxia; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Tyrosine; Ubiquitin-Protein Ligases; Ubiquitination; Ultrasonic Waves; United Kingdom; United States; United States Department of Veterans Affairs; Up-Regulation; Urea; Uric Acid; Urinary Bladder Neoplasms; Urinary Bladder, Neurogenic; Urine; Urodynamics; User-Computer Interface; Vemurafenib; Verbenaceae; Veterans; Veterans Health; Viral Load; Virtual Reality; Vitiligo; Water Pollutants, Chemical; Wildfires; Wnt Signaling Pathway; Wound Healing; X-Ray Diffraction; Xenograft Model Antitumor Assays; Xylenes; Young Adult; Zinc; Zinc Oxide; Zinc Sulfate; Zoonoses | 2021 |
Masitinib for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Benzamides; Cognition; Humans; Piperidines; Protein Kinase Inhibitors; Pyridines; Thiazoles | 2021 |
Fyn Kinase Activity and Its Role in Neurodegenerative Disease Pathology: a Potential Universal Target?
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzamides; Central Nervous System; Dasatinib; Humans; Molecular Targeted Therapy; Multiple Sclerosis; Myelin Sheath; Nerve Tissue Proteins; Neurodegenerative Diseases; Oligodendroglia; Parkinson Disease; Piperidines; Proto-Oncogene Proteins c-fyn; PrPC Proteins; Pyridines; Receptors, N-Methyl-D-Aspartate; T-Cell Antigen Receptor Specificity; T-Lymphocyte Subsets; tau Proteins; Thiazoles | 2021 |
A systematic review on drugs for synaptic plasticity in the treatment of dementia.
Topics: Alzheimer Disease; Benzamides; Bryostatins; Humans; Levetiracetam; Neuronal Plasticity; Piperidines; Pyridines; Thiazoles | 2022 |
62 trial(s) available for thiazoles and piperidines
| Article | Year |
|---|---|
[Piprozoline in clinical trials (author's transl)].
Topics: Adolescent; Adult; Aged; Biliary Tract Diseases; Cholagogues and Choleretics; Clinical Trials as Topic; Drug Evaluation; Female; Gastrointestinal Diseases; Hepatomegaly; Humans; Liver Diseases; Liver Function Tests; Male; Middle Aged; Piperidines; Thiazoles | 1977 |
[Effect on carbohydrate metabolism of a new saluretic, etozolin].
Topics: Adult; Aged; Blood Glucose; Carbohydrate Metabolism; Clinical Trials as Topic; Diabetes Mellitus; Drug Tolerance; Glucose Tolerance Test; Humans; Insulin; Middle Aged; Piperidines; Thiazoles; Time Factors | 1979 |
[Etozoline in the ambulatory edema therapy of decompensated cardiac patients].
Topics: Diuretics; Edema; Female; Heart Failure; Humans; Male; Mefruside; Piperidines; Thiazoles | 1979 |
[Studies on the diuretic effects of etozolin (Elkapin) in heart failure - a comparison with the loop diuretic agent furosemide (author's transl)].
Topics: Blood Cell Count; Blood Pressure; Body Weight; Diuretics; Electrolytes; Furosemide; Heart Failure; Heart Rate; Humans; Piperidines; Thiazoles | 1979 |
[Comparative studies on the diuretic activities of Etozolin and a reference compound in normal volunteers (author's transl)].
Topics: Adolescent; Adult; Benzothiadiazines; Diuresis; Diuretics; Humans; Male; Piperidines; Sodium Chloride Symporter Inhibitors; Thiazoles | 1977 |
[The anti-hypertensive effect of the diuretic etozolin. Results of a double-blind test].
Topics: Diuretics; Double-Blind Method; Drug Evaluation; Humans; Hypertension; Piperidines; Placebos; Thiazoles | 1978 |
[Effect of the saluretic etozoline on the blood coagulation and fibrinolytic systems and other clinical parameters in healthy individuals].
Topics: Blood Coagulation; Blood Coagulation Tests; Diuretics; Fibrinolysis; Humans; Piperidines; Thiazoles | 1978 |
Antihypoxic treatment at an early stage of diabetic neuropathy: an electrophysiological study with sabeluzole.
Topics: Adult; Aged; Autonomic Nervous System Diseases; Cell Hypoxia; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Double-Blind Method; Electromyography; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nerve Degeneration; Neurologic Examination; Peripheral Nerves; Piperidines; Sensory Thresholds; Synaptic Transmission; Thiazoles | 1992 |
The effect of R 58 735 (Sabeluzole) on memory functions in healthy elderly volunteers.
Topics: Cognition; Double-Blind Method; Female; Humans; Learning; Male; Memory; Middle Aged; Piperidines; Reaction Time; Thiazoles | 1988 |
The effect of sabeluzole (R 58735) on memory retrieval functions.
Topics: Adult; Double-Blind Method; Female; Humans; Male; Memory; Middle Aged; Piperidines; Random Allocation; Thiazoles | 1988 |
Sabeluzole (R58 735) increases consistent retrieval during serial learning and relearning of nonsense syllables.
Topics: Double-Blind Method; Humans; Learning; Memory; Piperidines; Random Allocation; Serial Learning; Thiazoles | 1988 |
Effect of sabeluzole (R 58,735) on memory functions in patients with epilepsy.
Topics: Adult; Affect; Cognition; Double-Blind Method; Epilepsy; Female; Functional Laterality; Humans; Intelligence Tests; Male; Memory; Memory Disorders; Memory, Short-Term; Neuropsychological Tests; Piperidines; Psychomotor Performance; Reaction Time; Speech; Thiazoles | 1995 |
The negative inotropic and chronotropic effects of intravenous R 56865 during percutaneous transluminal coronary angioplasty.
Topics: Angioplasty, Balloon, Coronary; Benzothiazoles; Blood Gas Analysis; Blood Pressure; Calcium Channel Blockers; Cardiac Output; Coronary Circulation; Coronary Disease; Female; Humans; Male; Myocardial Contraction; Piperidines; Thiazoles; Ventricular Function, Left | 1995 |
Efficiency of the antihypoxic substance sabeluzole in patients with clinically and neurophysiologically evident diabetic polyneuropathy.
Topics: Adult; Aged; Autonomic Nervous System; Diabetic Neuropathies; Double-Blind Method; Female; Humans; Male; Middle Aged; Neurologic Examination; Peripheral Nerves; Piperidines; Thiazoles | 1993 |
[Treatment of polyneuropathy using sabeluzole].
Topics: Diabetic Neuropathies; Double-Blind Method; Female; Humans; Male; Middle Aged; Nervous System Diseases; Piperidines; Thiazoles | 1993 |
Lubeluzole in acute ischemic stroke. A double-blind, placebo-controlled phase II trial. Lubeluzole International Study Group.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Brain Ischemia; Cardiovascular Agents; Carotid Artery Diseases; Cerebrovascular Disorders; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Injections, Intravenous; Logistic Models; Male; Middle Aged; Multivariate Analysis; Piperidines; Placebos; Safety; Thiazoles | 1996 |
A double-blind, randomized trial of sabeluzole--a putative glutamate antagonist--in obstructive sleep apnea.
Topics: Adult; Aged; Cross-Over Studies; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Humans; Male; Middle Aged; Piperidines; Sleep Apnea Syndromes; Sleep Stages; Sleep, REM; Thiazoles | 1996 |
Treatment of Alzheimer's disease with sabeluzole: functional and structural correlates.
Topics: Aged; Alzheimer Disease; Brain; Cognition; Double-Blind Method; Female; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Piperidines; Psychiatric Status Rating Scales; Thiazoles; Tomography, X-Ray Computed | 1997 |
The safety and tolerability of single intravenous doses of lubeluzole (Prosynap) in healthy volunteers.
Topics: Adult; Cardiovascular Agents; Dose-Response Relationship, Drug; Electrocardiography; Hemodynamics; Humans; Injections, Intravenous; Male; Piperidines; Single-Blind Method; Thiazoles | 1997 |
Lubeluzole treatment of acute ischemic stroke. The US and Canadian Lubeluzole Ischemic Stroke Study Group.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Brain Ischemia; Cerebrovascular Disorders; Double-Blind Method; Female; Heart Diseases; Humans; Male; Middle Aged; Mortality; Neuroprotective Agents; Piperidines; Survival Analysis; Thiazoles; Treatment Outcome | 1997 |
Effect of SR121566A, a potent GP IIb-IIIa antagonist, on the HIT serum/heparin-induced platelet mediated activation of human endothelial cells.
Topics: Adenosine Diphosphate; Antibodies; Benzylamines; Cytokines; Endothelium, Vascular; Heparin; Humans; Membrane Proteins; Piperidines; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Reference Values; Risk Factors; Serotonin; Thiazoles; Thrombocytopenia | 1998 |
Pharmacokinetics of lubeluzole (Prosynap) after single intravenous doses in healthy subjects.
Topics: Adult; Humans; Infusions, Intravenous; Male; Middle Aged; Neuroprotective Agents; Piperidines; Single-Blind Method; Thiazoles | 1998 |
Early clinical and radiological predictors of fatal brain swelling in ischemic stroke.
Topics: Acute Disease; Aged; Brain Edema; Brain Ischemia; Case-Control Studies; Cerebral Arteries; Female; Hospital Mortality; Humans; Male; Middle Aged; Neuroprotective Agents; Piperidines; Prognosis; Risk Factors; Severity of Illness Index; Thiazoles; Tomography, X-Ray Computed | 1999 |
Repaglinide/troglitazone combination therapy: improved glycemic control in type 2 diabetes.
Topics: Adult; Aged; Biomarkers; Blood Glucose; Carbamates; Chromans; Cross-Over Studies; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Middle Aged; Piperidines; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Lubeluzole in acute ischemic stroke treatment: A double-blind study with an 8-hour inclusion window comparing a 10-mg daily dose of lubeluzole with placebo.
Topics: Acute Disease; Aged; Double-Blind Method; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Male; Neuroprotective Agents; Piperidines; Placebos; Severity of Illness Index; Stroke; Thiazoles; Treatment Outcome | 2000 |
The validity and reliability of signs of early infarction on CT in acute ischaemic stroke.
Topics: Adult; Aged; Aged, 80 and over; Cerebral Infarction; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Neuroprotective Agents; Observer Variation; Piperidines; Predictive Value of Tests; Randomized Controlled Trials as Topic; Reproducibility of Results; Thiazoles; Thrombolytic Therapy; Time Factors; Tissue Plasminogen Activator; Tomography, X-Ray Computed | 2000 |
Pharmacokinetics of sabeluzole and dextromethorphan oxidation capacity in patients with severe hepatic dysfunction and healthy volunteers.
Topics: Adult; Antitussive Agents; Cytochrome P-450 CYP2D6; Dextromethorphan; Humans; Liver; Liver Diseases; Male; Middle Aged; Oxidation-Reduction; Piperidines; Thiazoles | 2001 |
Combination therapy stroke trial. rt-PA +/- lubeluzole.
Topics: Drug Therapy, Combination; Feasibility Studies; Humans; Neuroprotective Agents; Piperidines; Stroke; Thiazoles | 2001 |
Combination Therapy Stroke Trial: recombinant tissue-type plasminogen activator with/without lubeluzole.
Topics: Activities of Daily Living; Aged; Cerebral Hemorrhage; Double-Blind Method; Feasibility Studies; Female; Glasgow Coma Scale; Humans; Male; Neuroprotective Agents; Piperidines; Plasminogen Activators; Prospective Studies; Recombinant Proteins; Stroke; Thiazoles; Tissue Plasminogen Activator | 2001 |
Moderate hyperglycaemia is associated with favourable outcome in acute lacunar stroke.
Topics: Acute Disease; Aged; Aged, 80 and over; Blood Glucose; Brain Infarction; Female; Humans; Hyperglycemia; Male; Middle Aged; Neuroprotective Agents; Piperidines; Prognosis; Severity of Illness Index; Stroke; Thiazoles; Treatment Outcome | 2007 |
Four-week, double-blind, placebo- and ziprasidone-controlled trial of iloperidone in patients with acute exacerbations of schizophrenia.
Topics: Acute Disease; Adolescent; Adult; Aged; Antipsychotic Agents; Double-Blind Method; Drug Administration Schedule; Female; Humans; Isoxazoles; Male; Middle Aged; Piperazines; Piperidines; Prospective Studies; Schizophrenia; Thiazoles; Treatment Outcome | 2008 |
Association of the NPAS3 gene and five other loci with response to the antipsychotic iloperidone identified in a whole genome association study.
Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Basic Helix-Loop-Helix Transcription Factors; Double-Blind Method; Female; Genome-Wide Association Study; Glial Cell Line-Derived Neurotrophic Factor Receptors; Humans; Isoxazoles; Male; Middle Aged; Nerve Tissue Proteins; Pharmacogenetics; Piperazines; Piperidines; Polymorphism, Single Nucleotide; Pseudogenes; Receptors, AMPA; Schizophrenia; Tenascin; Thiazoles; Transcription Factors; Young Adult | 2009 |
Whole genome association study identifies polymorphisms associated with QT prolongation during iloperidone treatment of schizophrenia.
Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Carrier Proteins; CELF Proteins; Cytoskeletal Proteins; Double-Blind Method; Electrocardiography; Female; Follow-Up Studies; Gene Frequency; Genome-Wide Association Study; Genotype; Humans; Intracellular Signaling Peptides and Proteins; Isoxazoles; Linear Models; Linkage Disequilibrium; Long QT Syndrome; Male; Middle Aged; Neuregulins; Organic Anion Transporters; Pharmacogenetics; Phosphoproteins; Phosphotransferases (Alcohol Group Acceptor); Piperazines; Piperidines; Polymorphism, Single Nucleotide; RNA-Binding Proteins; Schizophrenia; Thiazoles; Young Adult | 2009 |
An adaptive first in man dose-escalation study of NGX267: statistical, clinical, and operational considerations.
Topics: Adult; Algorithms; Clinical Trials, Phase I as Topic; Cohort Studies; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Humans; Male; Maximum Tolerated Dose; Muscarinic Agonists; Piperidines; Receptor, Muscarinic M1; Research Design; Spiro Compounds; Thiazoles | 2009 |
Phase 1 dose-escalation study of oral tyrosine kinase inhibitor masitinib in advanced and/or metastatic solid cancers.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Benzamides; Dose-Response Relationship, Drug; Female; Gastrointestinal Stromal Tumors; Humans; Male; Maximum Tolerated Dose; Middle Aged; Piperidines; Pyridines; Receptor Protein-Tyrosine Kinases; Thiazoles; Treatment Outcome | 2009 |
Masitinib in the treatment of active rheumatoid arthritis: results of a multicentre, open-label, dose-ranging, phase 2a study.
Topics: Adult; Aged; Arthritis, Rheumatoid; Benzamides; Dose-Response Relationship, Drug; Exanthema; Female; Humans; Male; Middle Aged; Piperidines; Prospective Studies; Pyridines; Thiazoles; Treatment Outcome | 2009 |
Applicability of a genetic signature for enhanced iloperidone efficacy in the treatment of schizophrenia.
Topics: Adult; Alleles; Antipsychotic Agents; Double-Blind Method; Female; Genetic Markers; Genotype; Humans; Isoxazoles; Likelihood Functions; Male; Middle Aged; Odds Ratio; Pharmacogenetics; Piperazines; Piperidines; Polymorphism, Single Nucleotide; Probability; Psychiatric Status Rating Scales; Psychometrics; Schizophrenia; Thiazoles; Treatment Outcome | 2009 |
Masitinib, a c-kit/PDGF receptor tyrosine kinase inhibitor, improves disease control in severe corticosteroid-dependent asthmatics.
Topics: Administration, Oral; Adolescent; Adult; Aged; Anti-Asthmatic Agents; Asthma; Benzamides; Edema; Exanthema; Female; France; Humans; Hydroxycorticosteroids; Male; Medication Adherence; Middle Aged; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyridines; Receptors, Platelet-Derived Growth Factor; Thiazoles; Treatment Outcome | 2009 |
Absence of weight gain association with the HTR2C -759C/T polymorphism in patients with schizophrenia treated with iloperidone.
Topics: Analysis of Variance; Antipsychotic Agents; Female; Follow-Up Studies; Gene Frequency; Genotype; Humans; Isoxazoles; Male; Piperazines; Piperidines; Polymorphism, Genetic; Receptor, Serotonin, 5-HT2C; Schizophrenia; Thiazoles; Weight Gain | 2010 |
Phase II study of oral masitinib mesilate in imatinib-naïve patients with locally advanced or metastatic gastro-intestinal stromal tumour (GIST).
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Benzamides; Disease-Free Survival; Dose-Response Relationship, Drug; Female; France; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Male; Middle Aged; Piperazines; Piperidines; Proto-Oncogene Proteins c-kit; Pyridines; Pyrimidines; Thiazoles; Treatment Outcome | 2010 |
Safety and activity of masitinib in combination with gemcitabine in patients with advanced pancreatic cancer.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Deoxycytidine; Disease Progression; Dose-Response Relationship, Drug; Endpoint Determination; Female; Gemcitabine; Hematologic Diseases; Humans; Male; Middle Aged; Pancreatic Neoplasms; Piperidines; Pyridines; Survival Analysis; Thiazoles | 2010 |
Masitinib for the treatment of systemic and cutaneous mastocytosis with handicap: a phase 2a study.
Topics: Adult; Benzamides; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Mastocytosis, Cutaneous; Mastocytosis, Systemic; Middle Aged; Mutation, Missense; Piperidines; Pyridines; Thiazoles; Treatment Outcome | 2010 |
Quantitative functional imaging by dynamic contrast enhanced ultrasonography (DCE-US) in GIST patients treated with masatinib.
Topics: Adult; Aged; Antineoplastic Agents; Benzamides; Blood Volume; Contrast Media; Female; Fluorodeoxyglucose F18; France; Gastrointestinal Stromal Tumors; Humans; Male; Middle Aged; Molecular Targeted Therapy; Perfusion Imaging; Phospholipids; Piperidines; Positron-Emission Tomography; Predictive Value of Tests; Prospective Studies; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyridines; Radiopharmaceuticals; Receptor, Fibroblast Growth Factor, Type 3; Receptors, Platelet-Derived Growth Factor; Sulfur Hexafluoride; Thiazoles; Time Factors; Tomography, X-Ray Computed; Treatment Outcome; Ultrasonography | 2012 |
Masitinib decreases signs of canine atopic dermatitis: a multicentre, randomized, double-blind, placebo-controlled phase 3 trial.
Topics: Animals; Benzamides; Dermatitis, Atopic; Dog Diseases; Dogs; Double-Blind Method; Drug Administration Schedule; Female; Male; Piperidines; Prospective Studies; Protein Kinase Inhibitors; Pyridines; Severity of Illness Index; Thiazoles; Treatment Outcome | 2011 |
Depression in patients with mastocytosis: prevalence, features and effects of masitinib therapy.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Benzamides; Depression; Female; Humans; Male; Mastocytosis; Middle Aged; Piperidines; Pyridines; Thiazoles; Young Adult | 2011 |
Efficacy of iloperidone in the short-term treatment of schizophrenia: a post hoc analysis of pooled patient data from four phase III, placebo- and active-controlled trials.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Antipsychotic Agents; Dose-Response Relationship, Drug; Double-Blind Method; Drug Labeling; Female; Haloperidol; Humans; Isoxazoles; Male; Middle Aged; Piperazines; Piperidines; Prospective Studies; Psychiatric Status Rating Scales; Psychotic Disorders; Risperidone; Schizophrenia; Thiazoles; Treatment Outcome; Young Adult | 2012 |
Masitinib treatment in patients with progressive multiple sclerosis: a randomized pilot study.
Topics: Administration, Oral; Benzamides; Female; France; Humans; Male; Middle Aged; Multiple Sclerosis; Pilot Projects; Piperidines; Placebo Effect; Pyridines; Thiazoles; Treatment Outcome | 2012 |
A thorough QTc study of 3 doses of iloperidone including metabolic inhibition via CYP2D6 and/or CYP3A4 and a comparison to quetiapine and ziprasidone.
Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dibenzothiazepines; Drug Administration Schedule; Drug Interactions; Drug Monitoring; Electrocardiography; Enzyme Inhibitors; Female; Genotype; Heart Rate; Humans; Isoxazoles; Ketoconazole; Linear Models; Long QT Syndrome; Male; Middle Aged; Paroxetine; Pharmacogenetics; Phenotype; Piperazines; Piperidines; Quetiapine Fumarate; Thiazoles; United States; Young Adult | 2013 |
Long-term safety and tolerability of iloperidone: results from a 25-week, open-label extension trial.
Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Substitution; Female; Humans; India; Isoxazoles; Longitudinal Studies; Male; Middle Aged; Piperazines; Piperidines; Psychiatric Status Rating Scales; Schizophrenia; Thiazoles; Time Factors; Treatment Outcome; United States; Young Adult | 2013 |
Magnetic resonance imaging is the preferred method to assess treatment-related skeletal changes in children with brain tumors.
Topics: Adolescent; Adult; Angiogenesis Inhibitors; Brain Stem Neoplasms; Child; Child, Preschool; Dasatinib; Female; Follow-Up Studies; Glioma; Humans; Infant; Knee Joint; Magnetic Resonance Imaging; Male; Osteonecrosis; Piperidines; Prospective Studies; Protein Kinase Inhibitors; Pyrimidines; Quinazolines; Radiography; Thiazoles; Vascular Endothelial Growth Factor Receptor-2 | 2013 |
Phase I trial, pharmacokinetics, and pharmacodynamics of vandetanib and dasatinib in children with newly diagnosed diffuse intrinsic pontine glioma.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Stem Neoplasms; Child; Child, Preschool; Dasatinib; Female; Glioma; Humans; Male; Piperidines; Pyrimidines; Quinazolines; Thiazoles; Treatment Outcome | 2013 |
A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration.
Topics: Analysis of Variance; Animals; Atrophy; Brain; Caloric Restriction; Case-Control Studies; Cognition Disorders; Cyclin-Dependent Kinase 5; Disease Models, Animal; Double-Blind Method; Excitatory Postsynaptic Potentials; Female; Green Fluorescent Proteins; Immunoprecipitation; In Vitro Techniques; Long-Term Potentiation; Male; Memory Disorders; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Nerve Tissue Proteins; Neurodegenerative Diseases; Phosphopyruvate Hydratase; Phosphotransferases; Piperidines; Silver Staining; Sirtuin 1; Synapses; Thiazoles; Tumor Suppressor Protein p53; Vitamin E | 2013 |
Pharmacodynamics of cholinesterase inhibitors suggests add-on therapy with a low-dose carbamylating inhibitor in patients on long-term treatment with rapidly reversible inhibitors.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Blotting, Western; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Drug Therapy, Combination; Fluorescence; Follow-Up Studies; Humans; Indans; Physostigmine; Piperidines; Thiazoles; Time Factors | 2014 |
Crenolanib is a potent inhibitor of FLT3 with activity against resistance-conferring point mutants.
Topics: Antineoplastic Agents; Benzimidazoles; Bone Marrow; Bone Marrow Cells; Colony-Forming Units Assay; Drug Resistance, Neoplasm; fms-Like Tyrosine Kinase 3; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; Piperidines; Point Mutation; Prognosis; Proto-Oncogene Proteins c-kit; Sequence Analysis, DNA; Tetrazolium Salts; Thiazoles; Time Factors | 2014 |
Masitinib in advanced gastrointestinal stromal tumor (GIST) after failure of imatinib: a randomized controlled open-label trial.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Benzamides; Disease-Free Survival; Female; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Indoles; Male; Middle Aged; Piperazines; Piperidines; Prospective Studies; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyridines; Pyrimidines; Pyrroles; Sunitinib; Thiazoles; Treatment Failure | 2014 |
A randomized, placebo-controlled phase III trial of masitinib plus gemcitabine in the treatment of advanced pancreatic cancer.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Biomarkers, Tumor; Carcinoma, Pancreatic Ductal; Deoxycytidine; Europe; Female; Gemcitabine; Humans; Intention to Treat Analysis; Male; Middle Aged; Oxidoreductases; Pancreatic Neoplasms; Pharmacogenetics; Piperidines; Precision Medicine; Predictive Value of Tests; Proportional Hazards Models; Prospective Studies; Protein Kinase Inhibitors; Pyridines; Risk Factors; Thiazoles; Time Factors; Treatment Outcome; United States | 2015 |
Masitinib monotherapy in canine epitheliotropic lymphoma.
Topics: Animals; Becaplermin; Benzamides; Dog Diseases; Dogs; Immunohistochemistry; Lymphoma, T-Cell; Piperidines; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-kit; Proto-Oncogene Proteins c-sis; Pyridines; Receptor, Platelet-Derived Growth Factor alpha; Receptor, Platelet-Derived Growth Factor beta; Remission Induction; Thiazoles; Treatment Outcome | 2016 |
Masitinib for treatment of severely symptomatic indolent systemic mastocytosis: a randomised, placebo-controlled, phase 3 study.
Topics: Adult; Aged; Aged, 80 and over; Asthenia; Benzamides; Diarrhea; Double-Blind Method; Exanthema; Female; Humans; Male; Mastocytosis, Systemic; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyridines; Severity of Illness Index; Thiazoles; Treatment Outcome; Urticaria; Young Adult | 2017 |
Changes in brain amyloid-β accumulation after donepezil administration.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Donepezil; Female; Functional Neuroimaging; Humans; Indans; Male; Nootropic Agents; Piperidines; Positron-Emission Tomography; Thiazoles; Time Factors | 2017 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor Proteins, Signal Transducing; Adenine; Adenocarcinoma; Adipogenesis; Administration, Cutaneous; Administration, Ophthalmic; Adolescent; Adsorption; Adult; Aeromonas hydrophila; Aerosols; Aged; Aged, 80 and over; Aging; Agriculture; Air Pollutants; Air Pollution; Airway Remodeling; Alanine Transaminase; Albuminuria; Aldehyde Dehydrogenase 1 Family; Algorithms; AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase; Alzheimer Disease; Amino Acid Sequence; Ammonia; Ammonium Compounds; Anaerobiosis; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Antibodies, Antineutrophil Cytoplasmic; Antibodies, Monoclonal, Humanized; Antifungal Agents; Antigens, Bacterial; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antitubercular Agents; Antiviral Agents; Apolipoproteins E; Apoptosis; Arabidopsis; Arabidopsis Proteins; Arsenic; Arthritis, Rheumatoid; Asthma; Atherosclerosis; ATP-Dependent Proteases; Attitude of Health Personnel; Australia; Austria; Autophagy; Axitinib; Bacteria; Bacterial Outer Membrane Proteins; Bacterial Proteins; Bacterial Toxins; Bacterial Typing Techniques; Bariatric Surgery; Base Composition; Bayes Theorem; Benzoxazoles; Benzylamines; beta Catenin; Betacoronavirus; Betula; Binding Sites; Biological Availability; Biological Oxygen Demand Analysis; Biomarkers; Biomarkers, Tumor; Biopsy; Bioreactors; Biosensing Techniques; Birth Weight; Blindness; Blood Chemical Analysis; Blood Gas Analysis; Blood Glucose; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Blood-Brain Barrier; Blotting, Western; Body Mass Index; Body Weight; Bone and Bones; Bone Density; Bone Resorption; Borates; Brain; Brain Infarction; Brain Injuries, Traumatic; Brain Neoplasms; Breakfast; Breast Milk Expression; Breast Neoplasms; Bronchi; Bronchoalveolar Lavage Fluid; Buffaloes; Cadherins; Calcification, Physiologic; Calcium Compounds; Calcium, Dietary; Cannula; Caprolactam; Carbon; Carbon Dioxide; Carboplatin; Carcinogenesis; Carcinoma, Ductal; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Cardiovascular Diseases; Carps; Carrageenan; Case-Control Studies; Catalysis; Catalytic Domain; Cattle; CD8-Positive T-Lymphocytes; Cell Adhesion; Cell Cycle Proteins; Cell Death; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Phone Use; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Cellulose; Chemical Phenomena; Chemoradiotherapy; Child; Child Development; Child, Preschool; China; Chitosan; Chlorocebus aethiops; Cholecalciferol; Chromatography, Liquid; Circadian Clocks; Circadian Rhythm; Circular Dichroism; Cisplatin; Citric Acid; Clinical Competence; Clinical Laboratory Techniques; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clostridioides difficile; Clostridium Infections; Coculture Techniques; Cohort Studies; Cold Temperature; Colitis; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type XI; Color; Connective Tissue Diseases; Copper; Coronary Angiography; Coronavirus 3C Proteases; Coronavirus Infections; Cost of Illness; Counselors; COVID-19; COVID-19 Testing; Creatine Kinase; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Cryoelectron Microscopy; Cryosurgery; Crystallography, X-Ray; Cues; Cultural Competency; Cultural Diversity; Curriculum; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase Inhibitor p21; Cycloparaffins; Cysteine Endopeptidases; Cytokines; Cytoplasm; Cytoprotection; Databases, Factual; Denitrification; Deoxycytidine; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diagnosis, Differential; Diatoms; Diet; Diet, High-Fat; Dietary Exposure; Diffusion Magnetic Resonance Imaging; Diketopiperazines; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Disease Progression; Disease-Free Survival; DNA; DNA Damage; DNA Glycosylases; DNA Repair; DNA-Binding Proteins; DNA, Bacterial; DNA, Viral; Docetaxel; Dose Fractionation, Radiation; Dose-Response Relationship, Drug; Down-Regulation; Doxorubicin; Drosophila; Drosophila melanogaster; Drug Carriers; Drug Delivery Systems; Drug Liberation; Drug Repositioning; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Drug Therapy, Combination; Edema; Edible Grain; Education, Graduate; Education, Medical, Graduate; Education, Pharmacy; Ehlers-Danlos Syndrome; Electron Transport Complex III; Electron Transport Complex IV; Electronic Nicotine Delivery Systems; Emergency Service, Hospital; Empathy; Emulsions; Endothelial Cells; Endurance Training; Energy Intake; Enterovirus A, Human; Environment; Environmental Monitoring; Enzyme Assays; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Epoxide Hydrolases; Epoxy Compounds; Erythrocyte Count; Erythrocytes; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Esophagectomy; Estrogens; Etanercept; Ethiopia; Ethnicity; Ethylenes; Exanthema; Exercise; Exercise Test; Exercise Tolerance; Extracellular Matrix; Extracorporeal Membrane Oxygenation; Eye Infections, Fungal; False Negative Reactions; Fatty Acids; Fecal Microbiota Transplantation; Feces; Female; Femur Neck; Fermentation; Ferritins; Fetal Development; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Fibroblasts; Fibroins; Fish Proteins; Flavanones; Flavonoids; Focus Groups; Follow-Up Studies; Food Handling; Food Supply; Food, Formulated; Forced Expiratory Volume; Forests; Fractures, Bone; Fruit and Vegetable Juices; Fusobacteria; G1 Phase Cell Cycle Checkpoints; G2 Phase Cell Cycle Checkpoints; Gamma Rays; Gastrectomy; Gastrointestinal Microbiome; Gastrointestinal Stromal Tumors; Gefitinib; Gels; Gemcitabine; Gene Amplification; Gene Expression; Gene Expression Regulation; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Plant; Gene Knockdown Techniques; Gene-Environment Interaction; Genotype; Germany; Glioma; Glomerular Filtration Rate; Glucagon; Glucocorticoids; Glycemic Control; Glycerol; Glycogen Synthase Kinase 3 beta; Glycolipids; Glycolysis; Goblet Cells; Gram-Negative Bacterial Infections; Granulocyte Colony-Stimulating Factor; Graphite; Greenhouse Effect; Guanidines; Haemophilus influenzae; HCT116 Cells; Health Knowledge, Attitudes, Practice; Health Personnel; Health Services Accessibility; Health Services Needs and Demand; Health Status Disparities; Healthy Volunteers; Heart Failure; Heart Rate; Heart Transplantation; Heart-Assist Devices; HEK293 Cells; Heme; Heme Oxygenase-1; Hemolysis; Hemorrhage; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hepatocytes; Hexoses; High-Throughput Nucleotide Sequencing; Hippo Signaling Pathway; Histamine; Histamine Agonists; Histidine; Histone Deacetylase 2; HIV Infections; HIV Reverse Transcriptase; HIV-1; Homebound Persons; Homeodomain Proteins; Homosexuality, Male; Hospice and Palliative Care Nursing; HSP70 Heat-Shock Proteins; Humans; Hyaluronan Receptors; Hydrogen; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrolysis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemia; Hypoglycemic Agents; Hypoxia; Idiopathic Interstitial Pneumonias; Imaging, Three-Dimensional; Imatinib Mesylate; Immunotherapy; Implementation Science; Incidence; INDEL Mutation; Induced Pluripotent Stem Cells; Industrial Waste; Infant; Infant, Newborn; Inflammation; Inflammation Mediators; Infliximab; Infusions, Intravenous; Inhibitory Concentration 50; Injections; Insecticides; Insulin-Like Growth Factor Binding Protein 5; Insulin-Secreting Cells; Interleukin-1; Interleukin-17; Interleukin-8; Internship and Residency; Intestines; Intracellular Signaling Peptides and Proteins; Ion Transport; Iridaceae; Iridoid Glucosides; Islets of Langerhans Transplantation; Isodon; Isoflurane; Isotopes; Italy; Joint Instability; Ketamine; Kidney; Kidney Failure, Chronic; Kidney Function Tests; Kidney Neoplasms; Kinetics; Klebsiella pneumoniae; Knee Joint; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Lactate Dehydrogenase 5; Laparoscopy; Laser Therapy; Lasers, Semiconductor; Lasers, Solid-State; Laurates; Lead; Leukocyte L1 Antigen Complex; Leukocytes, Mononuclear; Light; Lipid Peroxidation; Lipopolysaccharides; Liposomes; Liver; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Locomotion; Longitudinal Studies; Lopinavir; Lower Urinary Tract Symptoms; Lubricants; Lung; Lung Diseases, Interstitial; Lung Neoplasms; Lymphocyte Activation; Lymphocytes, Tumor-Infiltrating; Lymphoma, Mantle-Cell; Lysosomes; Macrophages; Male; Manganese Compounds; MAP Kinase Kinase 4; Mass Screening; Maternal Health; Medicine, Chinese Traditional; Melanoma, Experimental; Memantine; Membrane Glycoproteins; Membrane Proteins; Mesenchymal Stem Cell Transplantation; Metal Nanoparticles; Metalloendopeptidases; Metalloporphyrins; Methadone; Methane; Methicillin-Resistant Staphylococcus aureus; Mexico; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Mice, Nude; Mice, SCID; Mice, Transgenic; Microarray Analysis; Microbial Sensitivity Tests; Microbiota; Micronutrients; MicroRNAs; Microscopy, Confocal; Microsomes, Liver; Middle Aged; Milk; Milk, Human; Minority Groups; Mitochondria; Mitochondrial Membranes; Mitochondrial Proteins; Models, Animal; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Epidemiology; Molecular Structure; Molecular Weight; Multilocus Sequence Typing; Multimodal Imaging; Muscle Strength; Muscle, Skeletal; Muscular Diseases; Mutation; Mycobacterium tuberculosis; Myocardial Stunning; Myristates; NAD(P)H Dehydrogenase (Quinone); Nanocomposites; Nanogels; Nanoparticles; Nanotechnology; Naphthalenes; Nasal Cavity; National Health Programs; Necrosis; Needs Assessment; Neoadjuvant Therapy; Neonicotinoids; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasm Transplantation; Neoplasms; Neoplastic Stem Cells; Netherlands; Neuroblastoma; Neuroprotective Agents; Neutrophils; NF-kappa B; NFATC Transcription Factors; Nicotiana; Nicotine; Nitrates; Nitrification; Nitrites; Nitro Compounds; Nitrogen; Nitrogen Dioxide; North Carolina; Nuclear Magnetic Resonance, Biomolecular; Nuclear Proteins; Nucleic Acid Hybridization; Nucleosomes; Nutrients; Obesity; Obesity, Morbid; Oceans and Seas; Oncogene Protein v-akt; Oncogenes; Oocytes; Open Reading Frames; Osteoclasts; Osteogenesis; Osteoporosis; Osteoporosis, Postmenopausal; Outpatients; Ovarian Neoplasms; Ovariectomy; Overweight; Oxazines; Oxidants; Oxidation-Reduction; Oxidative Stress; Oxides; Oxidoreductases; Oxygen; Oxygen Inhalation Therapy; Oxygenators, Membrane; Ozone; Paclitaxel; Paenibacillus; Pain Measurement; Palliative Care; Pancreatic Neoplasms; Pandemics; Parasympathetic Nervous System; Particulate Matter; Pasteurization; Patient Preference; Patient Satisfaction; Pediatric Obesity; Permeability; Peroxiredoxins; Peroxynitrous Acid; Pharmaceutical Services; Pharmacists; Pharmacy; Phaseolus; Phenotype; Phoeniceae; Phosphates; Phosphatidylinositol 3-Kinases; Phospholipid Transfer Proteins; Phospholipids; Phosphorus; Phosphorylation; Photoperiod; Photosynthesis; Phylogeny; Physical Endurance; Physicians; Pilot Projects; Piperidines; Pituitary Adenylate Cyclase-Activating Polypeptide; Plant Extracts; Plant Leaves; Plant Proteins; Plant Roots; Plaque, Atherosclerotic; Pneumonia; Pneumonia, Viral; Point-of-Care Testing; Polyethylene Glycols; Polymers; Polysorbates; Pore Forming Cytotoxic Proteins; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Postprandial Period; Poverty; Pre-Exposure Prophylaxis; Prediabetic State; Predictive Value of Tests; Pregnancy; Pregnancy Trimester, First; Pregnancy, High-Risk; Prenatal Exposure Delayed Effects; Pressure; Prevalence; Primary Graft Dysfunction; Primary Health Care; Professional Role; Professionalism; Prognosis; Progression-Free Survival; Prolactin; Promoter Regions, Genetic; Proof of Concept Study; Proportional Hazards Models; Propylene Glycol; Prospective Studies; Prostate; Protein Binding; Protein Biosynthesis; Protein Isoforms; Protein Kinase Inhibitors; Protein Phosphatase 2; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein Transport; Proteoglycans; Proteome; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins c-ret; Proto-Oncogene Proteins p21(ras); Proton Pumps; Protons; Protoporphyrins; Pseudomonas aeruginosa; Pseudomonas fluorescens; Pulmonary Artery; Pulmonary Disease, Chronic Obstructive; Pulmonary Gas Exchange; Pulmonary Veins; Pyrazoles; Pyridines; Pyrimidines; Qualitative Research; Quinoxalines; Rabbits; Random Allocation; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Histamine H3; Receptors, Immunologic; Receptors, Transferrin; Recombinant Proteins; Recurrence; Reference Values; Referral and Consultation; Regional Blood Flow; Registries; Regulon; Renal Insufficiency, Chronic; Reperfusion Injury; Repressor Proteins; Reproducibility of Results; Republic of Korea; Research Design; Resistance Training; Respiration, Artificial; Respiratory Distress Syndrome; Respiratory Insufficiency; Resuscitation; Retinal Dehydrogenase; Retreatment; Retrospective Studies; Reverse Transcriptase Inhibitors; Rhinitis, Allergic; Ribosomal Proteins; Ribosomes; Risk Assessment; Risk Factors; Ritonavir; Rivers; RNA Interference; RNA-Seq; RNA, Messenger; RNA, Ribosomal, 16S; RNA, Small Interfering; Rosuvastatin Calcium; Rural Population; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salivary Ducts; Salivary Gland Neoplasms; San Francisco; SARS-CoV-2; Satiation; Satiety Response; Schools; Schools, Pharmacy; Seasons; Seawater; Selection, Genetic; Sequence Analysis, DNA; Serine-Threonine Kinase 3; Sewage; Sheep; Sheep, Domestic; Shock, Hemorrhagic; Signal Transduction; Silver; Silymarin; Single Photon Emission Computed Tomography Computed Tomography; Sirolimus; Sirtuin 1; Skin; Skin Neoplasms; Skin Physiological Phenomena; Sleep Initiation and Maintenance Disorders; Social Class; Social Participation; Social Support; Soil; Soil Microbiology; Solutions; Somatomedins; Soot; Specimen Handling; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis; Spinal Fractures; Spirometry; Staphylococcus aureus; STAT1 Transcription Factor; STAT3 Transcription Factor; Streptomyces coelicolor; Stress, Psychological; Stroke; Stroke Volume; Structure-Activity Relationship; Students, Medical; Students, Pharmacy; Substance Abuse Treatment Centers; Sulfur Dioxide; Surface Properties; Surface-Active Agents; Surveys and Questionnaires; Survival Analysis; Survival Rate; Survivin; Sweden; Swine; Swine, Miniature; Sympathetic Nervous System; T-Lymphocytes, Regulatory; Talaromyces; Tandem Mass Spectrometry; tau Proteins; Telemedicine; Telomerase; Telomere; Telomere Homeostasis; Temperature; Terminally Ill; Th1 Cells; Thiamethoxam; Thiazoles; Thiophenes; Thioredoxin Reductase 1; Thrombosis; Thulium; Thyroid Cancer, Papillary; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Time Factors; Titanium; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transcriptome; Transforming Growth Factor beta1; Transistors, Electronic; Translational Research, Biomedical; Transplantation Tolerance; Transplantation, Homologous; Transportation; Treatment Outcome; Tretinoin; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary; Tubulin Modulators; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Twins; Ultrasonic Therapy; Ultrasonography; Ultraviolet Rays; United States; Up-Regulation; Uranium; Urethra; Urinary Bladder; Urodynamics; Uromodulin; Uveitis; Vasoconstrictor Agents; Ventricular Function, Left; Vero Cells; Vesicular Transport Proteins; Viral Nonstructural Proteins; Visual Acuity; Vital Capacity; Vitamin D; Vitamin D Deficiency; Vitamin K 2; Vitamins; Volatilization; Voriconazole; Waiting Lists; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical; Whole Genome Sequencing; Wine; Wnt Signaling Pathway; Wound Healing; Wounds and Injuries; WW Domains; X-linked Nuclear Protein; X-Ray Diffraction; Xanthines; Xenograft Model Antitumor Assays; YAP-Signaling Proteins; Yogurt; Young Adult; Zebrafish; Zebrafish Proteins; Ziziphus | 2016 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acrylic Resins; Actinobacillus; Acute Disease; Acute Kidney Injury; Adaptor Proteins, Signal Transducing; Adenosine; Adenosine Triphosphate; Administration, Inhalation; Administration, Oral; Adolescent; Adult; Advance Care Planning; Africa, Northern; Age Factors; Aged; Aged, 80 and over; Air Pollutants; Air Pollution; Air Pollution, Indoor; Albendazole; Aluminum Oxide; Anastomosis, Surgical; Ancylostoma; Ancylostomiasis; Androstadienes; Angiogenesis Inhibitors; Angiotensin II; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antibodies, Bispecific; Antibodies, Viral; Anticoagulants; Antihypertensive Agents; Antinematodal Agents; Antineoplastic Agents; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antiporters; Antiviral Agents; Apoptosis; Aptamers, Nucleotide; Aromatase Inhibitors; Asian People; Astrocytes; Atrial Fibrillation; Auditory Threshold; Aurora Kinase B; Australia; Autophagy; Autophagy-Related Protein 5; Autotrophic Processes; Bacillus cereus; Bacillus thuringiensis; Bacterial Proteins; Beclin-1; Belgium; Benzene; Benzene Derivatives; Benzhydryl Compounds; beta Catenin; beta-Arrestin 2; Biliary Tract Diseases; Biofilms; Biofuels; Biomarkers; Biomarkers, Tumor; Biomass; Biomechanical Phenomena; Bioreactors; Biosensing Techniques; Biosynthetic Pathways; Bismuth; Blood Platelets; Bone and Bones; Bone Regeneration; Bortezomib; Botulinum Toxins, Type A; Brain; Brain Injuries; Brain Ischemia; Brain Neoplasms; Breast Neoplasms; Breath Tests; Bronchodilator Agents; Calcium Phosphates; Cannabis; Carbon Dioxide; Carbon Isotopes; Carcinogenesis; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cardiac Resynchronization Therapy; Cardiac Resynchronization Therapy Devices; Cardiomyopathies; Cardiovascular Diseases; Cariostatic Agents; Case Managers; Case-Control Studies; Catalysis; Cation Transport Proteins; CD8-Positive T-Lymphocytes; Cecropia Plant; Cell Adhesion; Cell Count; Cell Differentiation; Cell Division; Cell Line; Cell Line, Tumor; Cell Membrane; Cell Movement; Cell Proliferation; Cell Self Renewal; Cell Survival; Cells, Cultured; Cellular Reprogramming; Cellulose; Charcoal; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemokines; Chemoradiotherapy; Chemoreceptor Cells; Child; Child Abuse; Child, Preschool; China; Chlorogenic Acid; Chloroquine; Chromatography, Gas; Chronic Disease; Clinical Competence; Coated Materials, Biocompatible; Cochlea; Cohort Studies; Color; Comorbidity; Computer Simulation; Computer-Aided Design; Contraception; Contraceptive Agents, Female; Contrast Media; COP-Coated Vesicles; Coronavirus Infections; Cost of Illness; Coturnix; COVID-19; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Culex; Curriculum; Cyclic N-Oxides; Cytokines; Cytoplasm; Cytotoxicity, Immunologic; Cytotoxins; Databases, Factual; Deep Learning; Delivery, Obstetric; Denitrification; Dental Caries; Denture, Complete; Dexamethasone; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dielectric Spectroscopy; Diet, High-Fat; Dietary Fiber; Disease Models, Animal; Disease Progression; DNA; DNA Copy Number Variations; DNA, Mitochondrial; Dog Diseases; Dogs; Dopaminergic Neurons; Double-Blind Method; Down-Regulation; Doxorubicin; Drug Carriers; Drug Design; Drug Interactions; Drug Resistance, Bacterial; Drug Resistance, Neoplasm; Drug-Related Side Effects and Adverse Reactions; Drugs, Chinese Herbal; Dry Powder Inhalers; Dust; E2F1 Transcription Factor; Ecosystem; Education, Nursing; Education, Nursing, Baccalaureate; Electric Impedance; Electricity; Electrocardiography; Electrochemical Techniques; Electrochemistry; Electrodes; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Endothelial Cells; Environmental Monitoring; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Estrogen Receptor Modulators; Europe; Evoked Potentials, Auditory, Brain Stem; Exosomes; Feasibility Studies; Female; Ferricyanides; Ferrocyanides; Fibrinogen; Finite Element Analysis; Fistula; Fluorescent Dyes; Fluorides, Topical; Fluorodeoxyglucose F18; Fluticasone; Follow-Up Studies; Food Contamination; Food Microbiology; Foods, Specialized; Forensic Medicine; Frail Elderly; France; Free Radicals; Fresh Water; Fungi; Fungicides, Industrial; Galactosamine; Gastrointestinal Neoplasms; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Frequency; Genetic Predisposition to Disease; Genotype; Gingival Hemorrhage; Glioblastoma; Glioma; Glomerular Filtration Rate; Glomerulosclerosis, Focal Segmental; Glucose; Glucose Transport Proteins, Facilitative; Glucosides; Glutamine; Glycolysis; Gold; GPI-Linked Proteins; Gram-Negative Bacteria; Gram-Positive Bacteria; Graphite; Haplotypes; HCT116 Cells; Healthy Volunteers; Hearing Loss; Heart Failure; Hedgehog Proteins; HEK293 Cells; HeLa Cells; Hemodynamics; Hemorrhage; Hepatocytes; Hippo Signaling Pathway; Histone Deacetylases; Homeostasis; Hospital Mortality; Hospitalization; Humans; Hydantoins; Hydrazines; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Hydroxylamines; Hypoglycemic Agents; Immunity, Innate; Immunoglobulin G; Immunohistochemistry; Immunologic Factors; Immunomodulation; Immunophenotyping; Immunotherapy; Incidence; Indazoles; Indonesia; Infant; Infant, Newborn; Infarction, Middle Cerebral Artery; Inflammation; Injections, Intramuscular; Insecticides; Insulin-Like Growth Factor I; Insurance, Health; Intention to Treat Analysis; Interleukin-1 Receptor-Associated Kinases; Interleukin-6; Intrauterine Devices; Intrauterine Devices, Copper; Iron; Ischemia; Jordan; Keratinocytes; Kidney; Kidney Diseases; Kir5.1 Channel; Klebsiella Infections; Klebsiella pneumoniae; Lab-On-A-Chip Devices; Laparoscopy; Lasers; Lasers, Semiconductor; Lenalidomide; Leptin; Lethal Dose 50; Levonorgestrel; Limit of Detection; Lipid Metabolism; Lipid Metabolism Disorders; Lipogenesis; Lipopolysaccharides; Liquid Biopsy; Liver; Liver Abscess, Pyogenic; Liver Cirrhosis; Liver Diseases; Liver Neoplasms; Longevity; Lung Neoplasms; Luteolin; Lymph Nodes; Lymphocyte Activation; Macaca fascicularis; Macrophages; Mad2 Proteins; Magnetic Resonance Imaging; Male; Mammary Glands, Human; Manganese; Manganese Compounds; MAP Kinase Signaling System; Materials Testing; Maternal Health Services; MCF-7 Cells; Medicaid; Medicine, Chinese Traditional; Melanoma; Membrane Proteins; Mental Health; Mercury; Metal Nanoparticles; Metals, Heavy; Metformin; Methionine Adenosyltransferase; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Mice, Nude; Microalgae; Microbial Sensitivity Tests; Microglia; MicroRNAs; Microscopy, Atomic Force; Microscopy, Electron, Scanning; Middle Aged; Mitochondria; Mitochondrial Proteins; Mitral Valve; Mitral Valve Insufficiency; Models, Anatomic; Molecular Structure; Molybdenum; Monocarboxylic Acid Transporters; Moths; MPTP Poisoning; Multigene Family; Multiparametric Magnetic Resonance Imaging; Multiple Myeloma; Muscle, Skeletal; Mutagens; Mutation; Myeloid Cells; Nanocomposites; Nanofibers; Nanomedicine; Nanoparticles; Nanowires; Neoadjuvant Therapy; Neomycin; Neoplasm Grading; Neoplasm Recurrence, Local; Neoplasms; Neoplastic Stem Cells; Neostriatum; Neovascularization, Pathologic; Netherlands; Neuromuscular Agents; Neurons; NF-E2-Related Factor 2; NF-kappa B; Nickel; Nitrogen Oxides; Non-alcoholic Fatty Liver Disease; Nucleosides; Nucleotidyltransferases; Nutritional Status; Obesity, Morbid; Ofloxacin; Oils, Volatile; Oligopeptides; Oncogene Protein v-akt; Optical Imaging; Organic Cation Transport Proteins; Organophosphonates; Osteoarthritis; Osteoarthritis, Hip; Osteoarthritis, Knee; Osteoblasts; Osteogenesis; Oxidation-Reduction; Oxidative Stress; Oxides; Oxygen Isotopes; Pancreas; Pancreaticoduodenectomy; Pandemics; Particle Size; Particulate Matter; Patient Acceptance of Health Care; Patient Compliance; PC-3 Cells; Peptide Fragments; Peptides; Periodontal Attachment Loss; Periodontal Index; Periodontal Pocket; Periodontitis; Peroxides; Peru; Pest Control, Biological; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Phylogeny; Pilot Projects; Piperidines; Plant Bark; Plant Extracts; Plant Leaves; Plasmids; Platelet Function Tests; Pneumonia, Viral; Podocytes; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Polyethylene Terephthalates; Polymers; Polymorphism, Single Nucleotide; Porosity; Portugal; Positron-Emission Tomography; Postoperative Complications; Postural Balance; Potassium Channels, Inwardly Rectifying; Povidone; Powders; Precancerous Conditions; Precision Medicine; Predictive Value of Tests; Pregnancy; Prenatal Care; Prognosis; Promoter Regions, Genetic; Prospective Studies; Prostatectomy; Prostatic Neoplasms; Proteasome Inhibitors; Protective Agents; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-akt; Psychiatric Nursing; PTEN Phosphohydrolase; Pulmonary Embolism; Pyrimethamine; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reactive Oxygen Species; Receptor, ErbB-2; Receptor, IGF Type 1; Receptors, Estrogen; Receptors, G-Protein-Coupled; Recombinational DNA Repair; Recovery of Function; Regional Blood Flow; Renal Dialysis; Renin; Renin-Angiotensin System; Reperfusion Injury; Reproducibility of Results; Republic of Korea; Respiratory Distress Syndrome; Retrospective Studies; Rhodamines; Risk Assessment; Risk Factors; RNA, Long Noncoding; RNA, Messenger; Running; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salinity; Salmeterol Xinafoate; Sarcoma; Seasons; Shoulder Injuries; Signal Transduction; Silicon Dioxide; Silver; Sirtuin 1; Sirtuins; Skull Fractures; Social Determinants of Health; Sodium; Sodium Fluoride; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Glucose Transporter 2 Inhibitors; Soil; Soil Pollutants; Spain; Spectrophotometry; Spectroscopy, Fourier Transform Infrared; Staphylococcal Protein A; Staphylococcus aureus; Stem Cells; Stereoisomerism; Stomach Neoplasms; Streptomyces; Strontium; Structure-Activity Relationship; Students, Nursing; Substance-Related Disorders; Succinic Acid; Sulfur; Surface Properties; Survival Rate; Survivin; Symporters; T-Lymphocytes; Temozolomide; Tensile Strength; Thiazoles; Thiobacillus; Thiohydantoins; Thiourea; Thrombectomy; Time Factors; Titanium; Tobacco Mosaic Virus; Tobacco Use Disorder; Toll-Like Receptor 4; Toluene; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Toxicity Tests, Acute; Toxicity Tests, Subacute; Transcriptional Activation; Treatment Outcome; Troponin I; Tumor Cells, Cultured; Tumor Escape; Tumor Hypoxia; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Tyrosine; Ubiquitin-Protein Ligases; Ubiquitination; Ultrasonic Waves; United Kingdom; United States; United States Department of Veterans Affairs; Up-Regulation; Urea; Uric Acid; Urinary Bladder Neoplasms; Urinary Bladder, Neurogenic; Urine; Urodynamics; User-Computer Interface; Vemurafenib; Verbenaceae; Veterans; Veterans Health; Viral Load; Virtual Reality; Vitiligo; Water Pollutants, Chemical; Wildfires; Wnt Signaling Pathway; Wound Healing; X-Ray Diffraction; Xenograft Model Antitumor Assays; Xylenes; Young Adult; Zinc; Zinc Oxide; Zinc Sulfate; Zoonoses | 2021 |
Efficacy and Safety of Masitinib in Progressive Forms of Multiple Sclerosis: A Randomized, Phase 3, Clinical Trial.
Topics: Adolescent; Adult; Benzamides; Disease Progression; Double-Blind Method; Female; Humans; Male; Middle Aged; Multiple Sclerosis, Chronic Progressive; Outcome Assessment, Health Care; Piperidines; Protein Kinase Inhibitors; Pyridines; Thiazoles; Young Adult | 2022 |
483 other study(ies) available for thiazoles and piperidines
| Article | Year |
|---|---|
[On the pharmacology of piprozoline (author's transl)].
Topics: Amanitins; Animals; Bile; Bile Acids and Salts; Carbon Tetrachloride Poisoning; Cats; Chemical and Drug Induced Liver Injury; Cholagogues and Choleretics; Dogs; Female; Galactosamine; Lethal Dose 50; Male; Mice; Piperidines; Rats; Thiazoles | 1977 |
[Pharmacological effects of piprozoline on bile secretion in dogs (author's transl)].
Topics: Alkaline Phosphatase; Animals; Bile; Bile Acids and Salts; Bilirubin; Cholagogues and Choleretics; Cholesterol; Dogs; Female; Male; Piperidines; Proteins; Secretory Rate; Thiazoles | 1977 |
[Pharmacological effect of piprozoline on the exocrine pancreas of dogs (author's transl)].
Topics: Amylases; Animals; Bicarbonates; Dogs; Female; Lipase; Male; Pancreas; Pancreatic Juice; Piperidines; Proteins; Thiazoles; Trypsin | 1977 |
[Toxicological study on piprozoline (author's transl)].
Topics: Animals; Body Weight; Cholagogues and Choleretics; Dogs; Female; Fertility; Fetal Resorption; Male; Piperidines; Pregnancy; Rabbits; Rats; Teratogens; Thiazoles | 1977 |
[TLC-method for quantitative densitometric determination of piprozoline and its main metabolite using internal standards (author's transl)].
Topics: Cholagogues and Choleretics; Chromatography, Thin Layer; Densitometry; Piperidines; Thiazoles | 1977 |
[Metabolism and pharmacokinetics of piprozoline in the rat, dog and man. 1. Studies with the radioactively-labeled substance].
Topics: Administration, Oral; Adult; Animals; Biotransformation; Carbon Radioisotopes; Cholagogues and Choleretics; Chromatography, Thin Layer; Dogs; Humans; Kinetics; Male; Mass Spectrometry; Piperidines; Rats; Thiazoles | 1977 |
[Metabolism and pharmacokinetics of piprozoline in rat, dog and man. 2nd Communication: Determination of metabolic profiles with the aid of an HPLC-radioactivity detection system following direct injection of urine and bile onto a reversed-phase column (a
Topics: Adult; Animals; Bile; Cholagogues and Choleretics; Chromatography, High Pressure Liquid; Dogs; Glucuronates; Humans; Male; Piperidines; Rats; Thiazoles | 1977 |
[Metabolism and pharmacokinetics of piprozoline in rat, dog and man. 3rd communication: Determination of piprozoline and metabolite I in plasma and urine (author's transl)].
Topics: Administration, Oral; Animals; Biotransformation; Cholagogues and Choleretics; Dogs; Humans; Injections, Intravenous; Kinetics; Male; Piperidines; Rats; Thiazoles | 1977 |
[Studies on the influence of piprozoline on the microsomal enzyme system of the rat liver (author's transl)].
Topics: Animals; Cholagogues and Choleretics; Enzyme Induction; Glucuronates; Hexobarbital; Male; Microsomes, Liver; Oxidoreductases; Piperidines; Rats; Sleep; Thiazoles; Time Factors | 1977 |
[Structure-activity relationships of etozolin, a novel diuretic (author's transl)].
Topics: Chemical Phenomena; Chemistry, Physical; Diuretics; Magnetic Resonance Spectroscopy; Piperidines; Spectrophotometry, Infrared; Structure-Activity Relationship; Thermodynamics; Thiazoles | 1977 |
[On the pharmacology of Etozolin (author's transl)].
Topics: Animals; Bile; Blood Pressure; Diuresis; Diuretics; Dogs; Gallbladder; Hypertension; Piperidines; Rats; Thiazoles; Water-Electrolyte Balance | 1977 |
Effect of Etozolin on whole kidney function and fluid and electrolyte reabsorption in rat proximal convoluted tubules and loops of Henle.
Topics: Animals; Diuretics; Glomerular Filtration Rate; Kidney; Kidney Tubules; Kidney Tubules, Proximal; Loop of Henle; Male; Piperidines; Rats; Thiazoles; Water-Electrolyte Balance | 1977 |
[Toxicological studies on Etozolin (author's transl)].
Topics: Administration, Oral; Animals; Animals, Newborn; Diuretics; Dogs; Female; Fertility; Male; Maternal-Fetal Exchange; Piperidines; Pregnancy; Rabbits; Rats; Thiazoles; Water-Electrolyte Balance | 1977 |
[Absorption, distribution, metabolism and excretion of 14C Etozolin in the rat, dog and man].
Topics: Absorption; Animals; Anura; Chromatography, Thin Layer; Diuretics; Feces; Humans; Male; Piperidines; Protein Binding; Rats; Thiazoles | 1977 |
[Description of the pharmacokinetic behaviour of Etozolin and its main metabolite (author's transl)].
Topics: Administration, Oral; Animals; Biological Availability; Biotransformation; Diuretics; Dogs; Humans; Injections, Intravenous; Male; Piperidines; Rats; Thiazoles | 1977 |
The distribution of radioactivity in pregnant rats after repeated oral doses of the diuretic agent Etozolin.
Topics: Administration, Oral; Animals; Autoradiography; Biotransformation; Diuretics; Female; Fetus; Piperidines; Pregnancy; Rats; Thiazoles | 1977 |
[Effect of the diuretic Etozolin (Gö 687) on renal elimination of water and solutes in subjects with normal renal function (author's transl)].
Topics: Adult; Body Water; Chlorides; Creatinine; Diuretics; Humans; Kidney; Magnesium; Male; Piperidines; Potassium; Thiazoles; Water-Electrolyte Balance | 1977 |
[Effect of the diuretic Etozolin in patients with normal and impaired renal function (author's transl)].
Topics: Adult; Chlorides; Diuretics; Glomerular Filtration Rate; Humans; Kidney; Kidney Diseases; Middle Aged; Piperidines; Potassium; Sodium; Thiazoles; Water-Electrolyte Balance | 1977 |
[Elkapin--a new diuretic and antihypertensive agent].
Topics: Antihypertensive Agents; Diuretics; Edema; Female; Humans; Hypertension; Male; Piperidines; Thiazoles | 1978 |
Effects of R 56865 and phenytoin on mechanical, biochemical, and morphologic changes during ouabain intoxication in isolated perfused rabbit heart.
Topics: Adenosine Triphosphate; Animals; Benzothiazoles; Blood Pressure; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Heart; In Vitro Techniques; Lactates; Male; Mitochondria, Heart; Myocardial Contraction; Myocardium; Ouabain; Oxygen Consumption; Phenytoin; Phosphorylation; Piperidines; Rabbits; Thiazoles; Ventricular Function, Left | 1992 |
A tiaramide derivative, 5-chloro-3-(4-hydroxypiperadinocarbonylmethyl)benzothiazoline-2-one (HPR-611), a potent inhibitor of anaphylactic chemical mediator release--a distinctive feature from disodium cromoglycate.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzothiazoles; Cromolyn Sodium; Female; Guinea Pigs; Histamine Release; Humans; Leukotrienes; Lung; Mast Cells; Peritoneal Cavity; Piperazines; Piperidines; Rats; Thiazoles | 1992 |
Dependence of hypoxic cellular calcium loading on Na(+)-Ca2+ exchange.
Topics: Animals; Benzofurans; Benzothiazoles; Calcium; Cell Hypoxia; Ethers, Cyclic; Hydrogen-Ion Concentration; Indoles; Ischemia; Myocardium; Piperidines; Rats; Sodium; Sodium Channels; Sodium-Potassium-Exchanging ATPase; Thiazoles | 1992 |
Veratridine activates a silent sodium channel in rat isolated aorta.
Topics: Amiloride; Animals; Aorta; Benzothiazoles; Calcium; Guanidine; Guanidines; In Vitro Techniques; Piperidines; Pyrroles; Rats; Sodium Channels; Tetrodotoxin; Thiazoles; Vasodilator Agents; Veratridine | 1992 |
Potentiation of 2-deoxy-D-glucose antinociception, but not hyperphagia by zolantidine, a histamine (H2) receptor antagonist.
Topics: Animals; Benzothiazoles; Deoxyglucose; Histamine H2 Antagonists; Hot Temperature; Hyperphagia; Male; Nociceptors; Phenoxypropanolamines; Piperidines; Rats; Rats, Inbred Strains; Thiazoles | 1992 |
Inhibition of morphine antinociception by centrally administered histamine H2 receptor antagonists.
Topics: Animals; Benzothiazoles; Brain; Cimetidine; Histamine H2 Antagonists; Injections, Intraventricular; Male; Morphine; Nociceptors; Phenoxypropanolamines; Piperidines; Rats; Rats, Inbred Strains; Receptors, Histamine H2; Thiazoles | 1992 |
Central histaminergic involvement during stress in rats.
Topics: Animals; Antibody Formation; Benzothiazoles; Brain; Corticosterone; Histamine; Histamine H2 Antagonists; Histidine Decarboxylase; Male; Methylhistidines; Peptic Ulcer; Pheniramine; Phenoxypropanolamines; Piperidines; Rats; Rats, Wistar; Stress, Physiological; Thiazoles | 1992 |
Chronic treatment with sabeluzole protects cultured rat brain neurons from the neurotoxic effects of excitatory amino acids.
Topics: Amino Acids; Animals; Brain; Cells, Cultured; Glutamates; Glutamic Acid; L-Lactate Dehydrogenase; Microtubule-Associated Proteins; Neurons; Piperidines; Rats; Thiazoles; Time Factors | 1992 |
Differential effect of R 56865 on ouabain binding to isolated sarcolemma and intact atrial tissue of guinea-pig.
Topics: Animals; Benzothiazoles; Guinea Pigs; In Vitro Techniques; Myocardial Contraction; Myocardium; Ouabain; Piperidines; Sarcolemma; Sodium; Sodium-Potassium-Exchanging ATPase; Thiazoles | 1991 |
Sabeluzole, a memory-enhancing molecule, increases fast axonal transport in neuronal cell cultures.
Topics: Animals; Axonal Transport; Cell Line; Cells, Cultured; Embryo, Mammalian; Hippocampus; Kinesins; Memory; Microtubules; Neurites; Neuroblastoma; Neurons; Piperidines; Rats; Thiazoles | 1992 |
Suppressive effects of R 56865 on triggered propagated contractions and triggered arrhythmias in rat cardiac trabeculae.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Benzothiazoles; Calcium; Calcium Channel Blockers; Electric Stimulation; Female; Gallopamil; Heart Ventricles; In Vitro Techniques; Male; Myocardial Contraction; Piperidines; Rats; Rats, Inbred Strains; Sarcoplasmic Reticulum; Thiazoles | 1992 |
Effects of drugs on ventricular fibrillation and ischaemic K+ loss in a model of ischaemia in perfused guinea-pig hearts in vitro.
Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Benzothiazoles; Calcium Channel Blockers; Disease Models, Animal; Glipizide; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Myocardial Ischemia; Piperidines; Potassium; Potassium Channels; Pyrazines; Pyridines; Sympatholytics; Thiazoles; Ventricular Fibrillation | 1992 |
Lysophosphatidylcholine-induced Ca(2+)-overload in isolated cardiomyocytes and effect of cytoprotective drugs.
Topics: Animals; Benzothiazoles; Calcium; Flunarizine; Heart; Histocytochemistry; In Vitro Techniques; Intracellular Fluid; Ion Transport; Lysophosphatidylcholines; Microscopy, Electron; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Piperidines; Rabbits; Thiazoles | 1992 |
Single-dose and steady-state pharmacokinetics of sabeluzole in senile dementia of Alzheimer type patients.
Topics: Aged; Alzheimer Disease; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Piperidines; Thiazoles | 1992 |
Ouabain-induced changes of calcium and potassium in slices of hippocampus of the rat: comparison to hypoxia and effect of R 56865.
Topics: Animals; Benzothiazoles; Brain Ischemia; Calcium; Disease Models, Animal; Hippocampus; Hypoxia, Brain; In Vitro Techniques; Male; Ouabain; Piperidines; Potassium; Rats; Rats, Inbred Strains; Thiazoles | 1992 |
Sodium-dependent potassium (86Rb+) efflux moderates volume regulation by cells in rat renal inner medullary slices exposed to strongly hyperosmotic media.
Topics: Animals; Benzothiazoles; Biological Transport; In Vitro Techniques; Kidney Medulla; Male; Piperidines; Potassium; Potassium Channels; Rats; Rubidium Radioisotopes; Thiazoles; Water-Electrolyte Balance | 1992 |
Flunarizine and R 56865 suppress veratridine-induced increase in oxygen consumption and uptake of 45Ca2+ in rat cortical synaptosomes.
Topics: Animals; Benzothiazoles; Calcium; Calcium Radioisotopes; Cerebral Cortex; Flunarizine; In Vitro Techniques; Oxygen Consumption; Piperidines; Polarography; Rats; Synaptosomes; Tetrodotoxin; Thiazoles; Veratridine | 1992 |
Pharmacological studies of arrhythmias induced by rose bengal photoactivation.
Topics: Animals; Antioxidants; Arrhythmias, Cardiac; Benzothiazoles; Coronary Circulation; Electrocardiography; Free Radicals; Heart Rate; Male; Oxygen; Photolysis; Piperidines; Rats; Rats, Inbred Strains; Rose Bengal; Superoxides; Thiazoles | 1991 |
Agonistic and antagonistic effect of R56865 on the Na+ channel in cardiac cells.
Topics: Animals; Benzothiazoles; Guinea Pigs; Heart; Membrane Potentials; Myocardium; Papillary Muscles; Piperidines; Purkinje Cells; Rabbits; Sodium; Sodium Channels; Thiazoles | 1991 |
Myocardial protection by R 56865: a new principle based on prevention of ion channel pathology.
Topics: Animals; Benzothiazoles; Calcium; Cardiomyopathies; Heart; Lysophosphatidylcholines; Myocardial Contraction; Ouabain; Oxygen; Piperidines; Rabbits; Rats; Singlet Oxygen; Sodium; Sodium Channels; Tetrodotoxin; Thiazoles; Veratridine | 1991 |
Preferential block of the veratridine-induced, non-inactivating Na+ current by R56865 in single cardiac Purkinje cells.
Topics: Animals; Benzothiazoles; Heart; In Vitro Techniques; Membrane Potentials; Myocardium; Piperidines; Purkinje Cells; Rabbits; Sodium Channels; Tetrodotoxin; Thiazoles; Veratridine | 1991 |
Veratridine-induced intoxication in the isolated left atrium of the rat: effects of some anti-ischemic compounds.
Topics: Animals; Atrial Function, Left; Benzothiazoles; Calcium; Coronary Disease; Dose-Response Relationship, Drug; Heart; In Vitro Techniques; Male; Piperidines; Pyrroles; Rats; Sodium; Sodium Channels; Thiazoles; Veratridine | 1991 |
Characterization of the interaction of R 56865 with cardiac Na- and L-type Ca channels.
Topics: Action Potentials; Animals; Benzothiazoles; Biomechanical Phenomena; Calcium Channels; Guinea Pigs; Heart; In Vitro Techniques; Myocardium; Papillary Muscles; Piperidines; Sodium; Sodium Channels; Thiazoles; Veratridine | 1991 |
Protective effects of R 56 865 against ischemic damage in the isolated rabbit heart.
Topics: Animals; Benzothiazoles; Calcium; Calcium Channels; Cell Death; Coronary Disease; Female; Hemodynamics; In Vitro Techniques; Male; Mitochondria, Heart; Myocardial Reperfusion Injury; Myocardium; Perfusion; Piperidines; Rabbits; Subcellular Fractions; Thiazoles; Verapamil | 1991 |
Effects of thioperamide, a histamine H3 receptor antagonist, on locomotor activity and brain histamine content in mast cell-deficient W/Wv mice.
Topics: Animals; Benzothiazoles; Brain Chemistry; Dopamine; Histamine; Histamine Antagonists; Histamine H2 Antagonists; Mast Cells; Methylhistamines; Mice; Mice, Mutant Strains; Motor Activity; Phenoxypropanolamines; Piperidines; Pyrilamine; Receptors, Histamine H3; Thiazoles | 1991 |
Effects of an alpha 2 antagonist in a 20-year-old Java monkey with MPTP-induced parkinsonian signs.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adrenergic alpha-Antagonists; Animals; Blinking; Locus Coeruleus; Macaca fascicularis; Neurons; Parkinson Disease, Secondary; Piperidines; Thiazoles; Tremor | 1991 |
[Experimental study on the principal effects and dependence potential of thiofentanil].
Topics: Analgesics, Opioid; Animals; Dogs; Female; Immobilization; Macaca mulatta; Male; Mice; Pain; Piperidines; Rabbits; Rats; Sensory Thresholds; Substance Withdrawal Syndrome; Substance-Related Disorders; Thiazoles | 1991 |
S14063: a new potent 5-HT1A receptor antagonist devoid of beta-adrenoceptor blocking properties.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Animals; Benzothiazoles; Blood Pressure; Heart Rate; Male; Piperidines; Rats; Rats, Inbred Strains; Serotonin Antagonists; Tetrahydronaphthalenes; Thiazoles | 1991 |
R56865, a potent new antiarrhythmic agent, effective during ischemia and reperfusion in the rat heart.
Topics: Analysis of Variance; Animals; Arrhythmias, Cardiac; Benzothiazoles; Calcium; Coronary Disease; Hemodynamics; In Vitro Techniques; Male; Myocardial Reperfusion; Piperidines; Potassium; Rats; Rats, Inbred Strains; Thiazoles | 1990 |
Effects of R56865 on membrane currents in isolated ventricular cardiomyocytes of the guinea-pig.
Topics: Animals; Benzothiazoles; Cadmium; Cesium; Guinea Pigs; Heart; In Vitro Techniques; Ion Channels; Membranes; Myocardium; Piperidines; Potassium Channels; Sodium Channels; Thiazoles | 1990 |
Differential influence of various calcium-modulating compounds on ouabain intoxication in isolated rat left atria.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Atrial Function; Atrial Function, Left; Benzothiazoles; Calcium; Calcium Channel Blockers; Cardiotonic Agents; Heart; Heart Atria; Intracellular Fluid; Male; Myocardial Contraction; Myocardium; Ouabain; Piperidines; Potassium; Rats; Rats, Inbred Strains; Sodium; Thiazoles | 1990 |
Effects of R 56,865, a preventer of cellular calcium overload, on left ventricular diastolic properties during pacing-induced ischemia in dogs.
Topics: Animals; Benzothiazoles; Blood Pressure; Cardiac Pacing, Artificial; Coronary Disease; Coronary Vessels; Diastole; Dogs; Female; Heart Rate; Hemodynamics; Male; Piperidines; Propranolol; Thiazoles; Ventricular Function, Left | 1991 |
Investigation of electrophysiologic mechanisms for the antiarrhythmic actions of R 56865 in cardiac glycoside toxicity.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Atrioventricular Node; Benzothiazoles; Blood Pressure; Cardiac Glycosides; Dogs; Electrophysiology; Female; Guinea Pigs; Heart Conduction System; In Vitro Techniques; Male; Membrane Potentials; Microelectrodes; Ouabain; Papillary Muscles; Piperidines; Purkinje Fibers; Refractory Period, Electrophysiological; Thiazoles | 1991 |
Sabeluzole improves social recognition and antagonizes chlordiazepoxide's effect on habituation in the rat.
Topics: Animals; Chlordiazepoxide; Cognition; Habituation, Psychophysiologic; Male; Memory, Short-Term; Motor Activity; Piperidines; Rats; Rats, Inbred Strains; Social Behavior; Thiazoles | 1991 |
Block of the transient inward current by R56865 in guinea-pig ventricular myocytes.
Topics: Action Potentials; Animals; Benzothiazoles; Calcium; Cricetinae; Digitalis; Electrophysiology; Heart; Heart Ventricles; Membrane Potentials; Muscle, Smooth, Vascular; Myocardium; Piperidines; Plants, Medicinal; Plants, Toxic; Rabbits; Sodium; Thiazoles | 1991 |
Naphthosultam derivatives: a new class of potent and selective 5-HT2 antagonists.
Topics: Animals; Behavior, Animal; Chemical Phenomena; Chemistry; Cyclic S-Oxides; Male; Mescaline; Mice; Molecular Structure; Naphthalenes; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Ritanserin; Serotonin Antagonists; Structure-Activity Relationship; Thiazoles | 1991 |
Sleep variables are unaltered by zolantidine in rats: are histamine H2-receptors not involved in sleep regulation?
Topics: Animals; Benzothiazoles; Diphenhydramine; Dose-Response Relationship, Drug; Histamine H2 Antagonists; Male; Phenoxypropanolamines; Piperidines; Rats; Rats, Inbred Strains; Receptors, Histamine H2; Reference Values; Sleep; Thiazoles; Time Factors; Wakefulness | 1990 |
Zolantidine-induced attenuation of morphine antinociception in rhesus monkeys.
Topics: Animals; Benzothiazoles; Dose-Response Relationship, Drug; Double-Blind Method; Female; Histamine H2 Antagonists; Macaca mulatta; Morphine; Pain; Phenoxypropanolamines; Piperidines; Thiazoles | 1990 |
Pharmacological treatment dose-relatedly improves learning and hippocampal long-term potentiation.
Topics: Animals; Avoidance Learning; Dose-Response Relationship, Drug; Electric Stimulation; Electrophysiology; Guinea Pigs; Hippocampus; Learning; Piperidines; Thiazoles | 1991 |
45Ca2+ movements induced by Ca2+ chloride in isolated rat aorta under K(+)-free conditions.
Topics: Amiloride; Animals; Aorta, Thoracic; Benzothiazoles; Calcium; Calcium Chloride; Calcium Radioisotopes; Flunarizine; In Vitro Techniques; Indomethacin; Lanthanum; Lidocaine; Nifedipine; omega-Conotoxins; Peptides, Cyclic; Piperidines; Potassium; Rats; Thiazoles; Vasoconstriction | 1991 |
Ionic channels, cholinergic mechanisms, and recovery of sensorimotor function after neocortical infarcts in rats.
Topics: Animals; Calcium Channel Blockers; Cerebral Infarction; Flunarizine; Male; Movement; Nervous System; Physical Stimulation; Piperidines; Rats; Rats, Inbred Strains; Scopolamine; Somatosensory Cortex; Thiazoles | 1990 |
Na(+)-activated K+ current in cardiac cells: rectification, open probability, block and role in digitalis toxicity.
Topics: Animals; Benzothiazoles; Biological Transport; Carrier Proteins; Digitalis Glycosides; Electric Conductivity; Guinea Pigs; Heart; Myocardium; Piperidines; Potassium; Potassium Channels; Sodium; Sodium-Potassium-Chloride Symporters; Thiazoles | 1990 |
A sodium-activated potassium current in intact ventricular myocytes isolated from the guinea-pig heart.
Topics: Action Potentials; Animals; Benzothiazoles; Calcium; Guinea Pigs; Heart; In Vitro Techniques; Magnesium; Piperidines; Potassium Channels; Sodium; Thiazoles | 1990 |
R 56865 and flunarizine displace Ca2+ from phosphatidylserine monolayers in a stoichiometric manner.
Topics: Benzothiazoles; Binding, Competitive; Calcium; Calcium Radioisotopes; Flunarizine; Hydrogen-Ion Concentration; Membranes, Artificial; Phosphatidylserines; Piperidines; Thiazoles | 1990 |
Phosphatidylserine monolayers as models for drug uptake into membranes and tissue.
Topics: Animals; Aorta; Benzothiazoles; Cell Membrane; Diltiazem; Erythrocyte Membrane; Flunarizine; Heart Atria; Humans; Lidocaine; Membranes, Artificial; Models, Biological; Nitrendipine; Pharmaceutical Preparations; Pharmacokinetics; Phosphatidylserines; Piperidines; Rats; Thiazoles; Verapamil | 1990 |
Class IV Ca2+ antagonists do not affect lipid peroxidation in singlet oxygen challenged cardiomyocytes.
Topics: Animals; Benzothiazoles; Calcium Channel Blockers; Cell Separation; Cinnarizine; Diltiazem; Flunarizine; Lidoflazine; Lipid Peroxidation; Malondialdehyde; Myocardium; Nicardipine; Oxygen; Piperidines; Rats; Thiazoles; Verapamil | 1990 |
A role for histamine and H2-receptors in opioid antinociception.
Topics: Analgesia; Animals; Benzothiazoles; Cimetidine; Histamine; Male; Morphine; Phenoxypropanolamines; Piperidines; Ranitidine; Rats; Rats, Inbred Strains; Receptors, Histamine H2; Receptors, Opioid; Thiazoles | 1989 |
R 56865 differentiates between contractile agents with respect to the nifedipine-sensitive component in the isolated rat aorta.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Arginine Vasopressin; Benzothiazoles; Calcium; Calcium Channels; Cytosol; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Piperidines; Rats; Rats, Inbred Strains; Serotonin; Thiazoles | 1989 |
Inhibition of naloxone-resistant antinociception by centrally administered H2-antagonists.
Topics: Analgesia; Animals; Benzothiazoles; Brain; Dose-Response Relationship, Drug; Drug Resistance; Histamine; Histamine H2 Antagonists; Male; Naloxone; Phenoxypropanolamines; Piperidines; Rats; Rats, Inbred Strains; Thiazoles | 1989 |
NMDA antagonists block restraint-induced increase in extracellular DOPAC in rat nucleus accumbens.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic alpha-Antagonists; Animals; Aspartic Acid; Carbolines; Convulsants; Diazepam; Male; N-Methylaspartate; Nucleus Accumbens; Phenylacetates; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Restraint, Physical; Riluzole; Septal Nuclei; Thiazoles | 1989 |
Pharmacological control of the human gastric histamine H2 receptor by famotidine: comparison with H1, H2 and H3 receptor agonists and antagonists.
Topics: Adenylyl Cyclases; Cyclic AMP; Famotidine; Gastric Fundus; Histamine; Histamine H2 Antagonists; Humans; In Vitro Techniques; Methylhistamines; Piperidines; Ranitidine; Receptors, Histamine; Stomach Neoplasms; Thiazoles; Triprolidine | 1989 |
Occurrence of yawning and decrease of prolactin levels via stimulation of dopamine D2-receptors after administration of SND 919 in rats.
Topics: alpha-Methyltyrosine; Animals; Azepines; Behavior, Animal; Benzothiazoles; Dopamine Agents; Male; Methyltyrosines; Piperidines; Pramipexole; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Thiazoles; Yawning | 1989 |
The protective action of R56865 against ouabain-induced intoxication in rat heart isolated atria and ventricles.
Topics: Animals; Benzothiazoles; Biological Transport, Active; Electric Stimulation; Erythrocytes; Heart; In Vitro Techniques; Male; Myocardial Contraction; Ouabain; Piperidines; Rats; Rats, Inbred Strains; Sodium; Thiazoles | 1989 |
Alzheimer's disease. Arresting memory decline.
Topics: Alzheimer Disease; Animals; Carbolines; Cholinesterase Inhibitors; Humans; Memory Disorders; Nicotine; Piperidines; Rats; Receptors, Cholinergic; Receptors, GABA-A; Receptors, Nicotinic; Thiazoles | 1988 |
Cholinergic effects of histamine-H2 receptor antagonists partly through inhibition of acetylcholinesterase.
Topics: Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Cimetidine; Famotidine; Guinea Pigs; Histamine H2 Antagonists; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Piperidines; Ranitidine; Thiazoles | 1986 |
Zolantidine (SK&F 95282) is a potent selective brain-penetrating histamine H2-receptor antagonist.
Topics: Animals; Benzothiazoles; Binding, Competitive; Brain Chemistry; Cimetidine; Cyclic AMP; Female; Guinea Pigs; Hippocampus; Histamine H2 Antagonists; In Vitro Techniques; Male; Phenoxypropanolamines; Piperidines; Rats; Thiazoles; Uterus | 1988 |
Effects of zolantidine a brain-penetrating H2-receptor antagonist, on naloxone-sensitive and naloxone-resistant analgesia.
Topics: Analgesia; Animals; Benzothiazoles; Brain; Drug Interactions; Drug Resistance; Histamine H2 Antagonists; Male; Naloxone; Phenoxypropanolamines; Piperidines; Rats; Rats, Inbred Strains; Thiazoles | 1988 |
H2-receptor-mediated stress-induced analgesia is dependent on neither pituitary nor adrenal activation.
Topics: Adrenalectomy; Analgesia; Animals; Benzothiazoles; Electroshock; Histamine H2 Antagonists; Hypophysectomy; Male; Naloxone; Phenoxypropanolamines; Piperidines; Rats; Rats, Inbred Strains; Receptors, Histamine H2; Reference Values; Thiazoles | 1988 |
Actions of the brain-penetrating H2-antagonist zolantidine on histamine dynamics and metabolism in rat brain.
Topics: Animals; Benzothiazoles; Brain; Brain Chemistry; Dose-Response Relationship, Drug; Histamine; Histamine N-Methyltransferase; In Vitro Techniques; Kidney; Kinetics; Methylhistamines; Methyltransferases; Phenoxypropanolamines; Piperidines; Rats; Rats, Inbred Strains; Thiazoles | 1988 |
Different effects of R 56865 and calcium entry blockers on K+- and noradrenaline-induced contractions and 45Ca uptake in rat aorta.
Topics: Animals; Aorta; Benzothiazoles; Calcium; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Flunarizine; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Piperidines; Potassium; Rats; Rats, Inbred Strains; Thiazoles; Verapamil | 1988 |
R 56865 prevents electrical and mechanical signs of ouabain intoxication in guinea-pig papillary muscle.
Topics: Animals; Arrhythmias, Cardiac; Benzothiazoles; Calcium; Electrophysiology; Guinea Pigs; Heart; In Vitro Techniques; Ouabain; Papillary Muscles; Piperidines; Thiazoles | 1987 |
Enhancement of divalent anion transport across the human red blood cell membrane by the water-soluble dansyl chloride derivative 2-(N-piperidine)ethylamine-1-naphthyl-5-sulfonylchloride (PENS-Cl).
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Benzothiazoles; Dansyl Compounds; Electrophoresis, Polyacrylamide Gel; Erythrocyte Membrane; Humans; Membrane Proteins; Piperidines; Potassium; Sulfates; Thiazoles; Time Factors | 1985 |
[Study of the gentoxocity of pharmaceutic preparations using rapid methods].
Topics: Benzothiazoles; Escherichia coli; Euglena gracilis; Furazolidone; Mutagenicity Tests; Nitrofurantoin; Nitrofurazone; Piperidines; Salmonella typhimurium; Thiazoles | 1985 |
The relative importance of dopaminergic and noradrenergic neuronal systems for the stimulation of locomotor activity induced by amphetamine and other drugs.
Topics: Amphetamine; Animals; Appetite; Carbon Radioisotopes; Diet; Disulfides; Dopamine; Dopamine beta-Hydroxylase; Dose-Response Relationship, Drug; Imidazoles; Male; Methylphenidate; Methyltyrosines; Mice; Motor Activity; Neurons; Norepinephrine; Phenmetrazine; Piperidines; Stimulation, Chemical; Thiazoles; Thiourea; Time Factors | 1973 |
[Application of sleep induced in the rat by sudden change in the environmental temperature to the study of antagonism between neurostimulants and hypnotics].
Topics: Amphetamine; Animals; Antidepressive Agents; Bemegride; Caffeine; Central Nervous System; Chloral Hydrate; Cocaine; Drug Antagonism; Environment; Hypnotics and Sedatives; Pentobarbital; Pentylenetetrazole; Piperidines; Pregnanediones; Rats; Secobarbital; Sleep; Strychnine; Temperature; Thiazoles | 1967 |
[Dehydro-N-Mannich bases due to condensation with s-triazine].
Topics: Amines; Benzimidazoles; Chemical Phenomena; Chemistry; Morpholines; Piperidines; Sulfhydryl Compounds; Thiazoles; Triazines | 1973 |
[N,N'-bis(2-thiazolyl)-formamidines].
Topics: Amidines; Amines; Chemical Phenomena; Chemistry; Piperidines; Spectrum Analysis; Thiazoles; Triazines | 1972 |
[The pharmacokinetics and metabolism of a new choleretic, 3-ethyl-4-oxo-5-piperidino- 2, -thiazolidineacetic acid ethyl ester (Piprozolin) after enteral administration in the rat].
Topics: Acetates; Administration, Oral; Animals; Bile; Carbon Isotopes; Cholagogues and Choleretics; Digestive System; Ethylamines; Feces; Ketones; Kinetics; Male; Piperidines; Rats; Thiazoles | 1972 |
[Research with experimental animals on the mechanism of action of the new choleretic, 3-ethyl-4-oxo-5-piperidino-delta 2, alpha-thiazolidine-acetic acid ethyl ester (Piprozolin)].
Topics: 1-Propanol; Acetates; Animals; Bile; Carbon Isotopes; Catheterization; Cats; Cholagogues and Choleretics; Dogs; Ethylamines; Ketones; Male; Piperidines; Rabbits; Rats; Rats, Inbred Strains; Thiazoles | 1972 |
[Studies on piperidine derivatives. IV. Studies on the synthesis of 3-oxo-1-thia-4,8-diazaspiro (4,5)decane derivatives. 2].
Topics: Piperidines; Spectrum Analysis; Spiro Compounds; Thiazoles | 1971 |
[Studies on piperidine derivatives. 3. Studies on the synthesis of 3-oxo-1-thia-4,8-diazaspiro [4,5] decane derivatives. (1)].
Topics: Amines; Chemical Phenomena; Chemistry; Piperidines; Piperidones; Spiro Compounds; Sulfhydryl Compounds; Thiazoles | 1971 |
[Reaction of piperidone dicarboxylic acid esters with o-amino-thio-phenol].
Topics: Chemical Phenomena; Chemistry; Dicarboxylic Acids; Esters; Ketones; Phenols; Piperidines; Thiazoles; Xylenes | 1970 |
[Syntheses of 2-dialkylamino-4,4-disubstituted 5(4H)-thiazolones].
Topics: Ketones; Piperidines; Spectrum Analysis; Thiazoles | 1970 |
[Synthesis of 5-derivatives of 2-piperidinothiazolin-2-on-4].
Topics: Chemistry, Pharmaceutical; Piperidines; Thiazoles | 1967 |
Control mechanisms in active chloride transport.
Topics: Adenosine Triphosphatases; Amidines; Animals; Biological Transport, Active; Cell Membrane Permeability; Chlorides; Diuretics; Furosemide; Kidney Tubules; Loop of Henle; Muzolimine; Ouabain; Oxygen Consumption; Piperidines; Rabbits; Sodium; Sodium-Potassium-Exchanging ATPase; Thiazoles | 1981 |
How do immunomodulators affect host defense in the burn patient?
Topics: Adjuvants, Immunologic; Animals; Antibodies, Monoclonal; Antibody Formation; Bacillus; Burns; Humans; Immunity, Cellular; Immunity, Innate; Interleukin-1; Interleukin-2; Neisseria; Peptide Fragments; Piperidines; Pyridines; Staphylococcus; Streptococcus; Sulfhydryl Compounds; Thiazoles; Thymopentin; Thymopoietins; Viruses; Wound Infection | 1984 |
Inner ear effects of a new loop diuretic (ozolinon).
Topics: Animals; Diuretics; Dose-Response Relationship, Drug; Ear, Inner; Endolymphatic Sac; Ethacrynic Acid; Guinea Pigs; Microelectrodes; Piperidines; Potassium; Stria Vascularis; Thiazoles | 1981 |
Testing strategy for ototoxic side effects.
Topics: Action Potentials; Animals; Bumetanide; Cats; Cochlea; Diuretics; Dose-Response Relationship, Drug; Female; Furosemide; Hearing Disorders; Male; Perfusion; Piperidines; Sulfonamides; Thiazoles; Vestibulocochlear Nerve | 1981 |
Stereospecific inhibition by ozolinone of stimulated chloride secretion in rabbit colon descendens.
Topics: Animals; Chlorides; Colon; Diuretics; Female; In Vitro Techniques; Male; Piperidines; Rabbits; Stereoisomerism; Thiazoles | 1982 |
Studies with the optically active isomers of the new diuretic drug ozolinone. I. Differences in stereoselectivity of the renal target structures of ozolinone.
Topics: Animals; Chlorides; Diuretics; Glomerular Filtration Rate; Kidney; Kidney Tubules, Distal; Loop of Henle; Male; p-Aminohippuric Acid; Piperidines; Rats; Regional Blood Flow; Sodium; Thiazoles | 1980 |
Studies with the optically active isomers of the new diuretic drug ozolinone. II. Inhibition by d-ozolinone of furosemide-induced diuresis.
Topics: Animals; Diuresis; Diuretics; Furosemide; Glomerular Filtration Rate; Kidney; Kidney Tubules, Proximal; Loop of Henle; Male; Piperidines; Rats; Regional Blood Flow; Thiazoles | 1980 |
Assay of etozolin and its main metabolite, ozolinone, in plasma by high performance liquid chromatography.
Topics: Benzothiadiazines; Chromatography, High Pressure Liquid; Diuretics; Humans; Piperidines; Sodium Chloride Symporter Inhibitors; Thiazoles; Time Factors | 1980 |
Determination of etozolin and ozolinone in human plasma and tissues by reversed-phase high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Female; Fetus; Humans; Maternal-Fetal Exchange; Piperidines; Placenta; Pregnancy; Pregnancy Trimester, First; Pregnancy Trimester, Second; Reference Values; Thiazoles | 1981 |
Effects of thioperamide, a histamine H3-receptor antagonist, on a scopolamine-induced learning deficit using an elevated plus-maze test in mice.
Topics: Animals; Benzothiazoles; Histamine; Histamine Antagonists; Male; Maze Learning; Mice; Mice, Inbred ICR; Phenoxypropanolamines; Piperidines; Scopolamine; Thiazoles | 1995 |
Dopamine receptor agonist potencies for inhibition of cell firing correlate with dopamine D3 receptor binding affinities.
Topics: Aminoquinolines; Animals; Apomorphine; Azepines; Benzothiazoles; Binding, Competitive; CHO Cells; Cricetinae; Dopamine Agonists; Dose-Response Relationship, Drug; Ergolines; Imidazoles; Male; Neurons; Phenethylamines; Piperidines; Pramipexole; Quinolines; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Structure-Activity Relationship; Substantia Nigra; Tetrahydronaphthalenes; Thiazoles; Thiophenes; Transfection | 1995 |
Histaminergic neurons mediate restraint stress-induced activation of central 5-hydroxytryptaminergic neurons in the rat.
Topics: Animals; Benzothiazoles; Histamine; Histamine H2 Antagonists; Histidine Decarboxylase; Hydroxyindoleacetic Acid; Male; Methylhistidines; Neurons; Nucleus Accumbens; Phenoxypropanolamines; Piperidines; Pyrilamine; Rats; Receptors, Histamine H1; Restraint, Physical; Serotonin; Suprachiasmatic Nucleus; Thiazoles | 1994 |
Ion channel involvement in anoxic depolarization induced by cardiac arrest in rat brain.
Topics: Adenosine Triphosphate; Animals; Benzothiazoles; Calcium; Dizocilpine Maleate; Flunarizine; Glyburide; Heart Arrest; Hypoxia; Ion Channels; Male; Nimodipine; Piperidines; Potassium; Potassium Channels; Quinoxalines; Rats; Rats, Wistar; Sodium; Thiazoles | 1995 |
Effects of a histamine H2 receptor agonist and antagonist on restraint-induced antinociception in female mice.
Topics: Animals; Benzothiazoles; Cimetidine; Dimaprit; Female; Histamine Agonists; Histamine H2 Antagonists; Mice; Mice, Inbred Strains; Pain Measurement; Phenoxypropanolamines; Piperidines; Reaction Time; Restraint, Physical; Stress, Psychological; Thiazoles | 1995 |
Enzymatic activity of DPIV/CD26 is involved in PMA-induced hyperphosphorylation of p56lck.
Topics: Dipeptidyl Peptidase 4; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Humans; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Lysine; Phosphorylation; Piperidines; Protease Inhibitors; Protein Kinase C; src-Family Kinases; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thiazoles | 1995 |
Modulation of morphine antinociception by the brain-penetrating H2 antagonist zolantidine: detailed characterization in five nociceptive test systems.
Topics: Animals; Benzothiazoles; Blood-Brain Barrier; Histamine H2 Antagonists; Hot Temperature; Male; Morphine; Pain; Pain Measurement; Phenoxypropanolamines; Piperidines; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Thiazoles | 1995 |
Alleviation of contractile dysfunction in ischemic hearts by slowly inactivating Na+ current blockers.
Topics: Action Potentials; Animals; Benzothiazoles; Biomechanical Phenomena; Electric Conductivity; Guinea Pigs; Heart; In Vitro Techniques; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion; Papillary Muscles; Piperidines; Reference Values; Sodium; Tetrodotoxin; Thiazoles | 1995 |
Cardioprotective drugs decrease the Na+ background current.
Topics: Amiloride; Animals; Benzothiazoles; Guinea Pigs; Heart; Heart Arrest, Induced; Myocardium; Piperidines; Potassium; Sodium; Thiazoles; Verapamil | 1995 |
Importance of histamine H2 receptors in restraint-morphine interactions.
Topics: Analysis of Variance; Animals; Benzothiazoles; Histamine; Histamine H2 Antagonists; Male; Morphine; Pain; Phenoxypropanolamines; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Histamine H2; Restraint, Physical; Thiazoles; Time Factors | 1995 |
Sabeluzole administration does not enhance fast axonal transport in normal adult rat sciatic nerve.
Topics: Animals; Axonal Transport; Biological Transport; Calcitonin Gene-Related Peptide; Male; Mixed Function Oxygenases; Piperidines; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Synaptophysin; Thiazoles | 1993 |
R 56 865, a Na+/Ca(2+)-overload inhibitor, protects against aconitine-induced cardiac arrhythmias in vivo.
Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Benzothiazoles; Calcium; Dose-Response Relationship, Drug; Hemodynamics; Lidocaine; Male; Piperidines; Random Allocation; Rats; Rats, Wistar; Sodium; Sodium Channels; Tetrodotoxin; Thiazoles; Verapamil | 1993 |
Effect of R56865 on cardiac sarcoplasmic reticulum function and its role as an antagonist of digoxin at the sarcoplasmic reticulum calcium release channel.
Topics: Adenosine Triphosphate; Animals; Benzothiazoles; Calcium; Calcium Channel Blockers; Calcium Channels; Digoxin; Dose-Response Relationship, Drug; Heart; Patch-Clamp Techniques; Piperidines; Sarcoplasmic Reticulum; Sheep; Thiazoles | 1995 |
Attenuation by R 56865, a novel cytoprotective drug, of regional myocardial ischemia- and reperfusion-induced electrocardiographic disturbances in anesthetized rabbits.
Topics: Analysis of Variance; Animals; Arrhythmias, Cardiac; Benzothiazoles; Calcium Channel Blockers; Disease Models, Animal; Dose-Response Relationship, Drug; Electrocardiography; Heart; Hemodynamics; Injections, Intravenous; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Piperidines; Rabbits; Random Allocation; Thiazoles | 1995 |
Effects of R56865, an Na(+)- and Ca(2+)-overload inhibitor, on myocardial injury in ischemic, reperfused porcine hearts.
Topics: Animals; Benzothiazoles; Blood Pressure; Calcium; Calcium Channel Blockers; Coronary Circulation; Female; Heart Rate; Injections, Intravenous; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Oxygen Consumption; Piperidines; Sodium; Sodium Channel Blockers; Swine; Thiazoles; Ventricular Fibrillation | 1995 |
Inhibitors of dipeptidyl peptidase IV (DP IV, CD26) specifically suppress proliferation and modulate cytokine production of strongly CD26 expressing U937 cells.
Topics: Blotting, Western; Cell Division; Cytokines; Dipeptidyl Peptidase 4; DNA; DNA Replication; Humans; Isoelectric Focusing; Lymphoma, Large B-Cell, Diffuse; Lysine; Piperidines; Thiazoles; Tumor Cells, Cultured | 1994 |
Effects of the histaminergic system on the morphine-induced conditioned place preference in mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzazepines; Benzothiazoles; Conditioning, Operant; Dihydroxyphenylalanine; Dopamine; Dose-Response Relationship, Drug; Histamine; Histamine H2 Antagonists; Histidine; Histidine Decarboxylase; Homovanillic Acid; Limbic System; Male; Methylhistidines; Mice; Mice, Inbred Strains; Morphine; Phenoxypropanolamines; Piperidines; Prosencephalon; Thiazoles | 1995 |
Characterization and function of histamine receptors in corpus cavernosum.
Topics: Acetylcholine; Animals; Cimetidine; Dimaprit; Dose-Response Relationship, Drug; Electric Stimulation; Histamine; Histamine Agonists; Histamine Antagonists; In Vitro Techniques; Male; Methylhistamines; Muscle Contraction; Papaverine; Penis; Piperidines; Pyrilamine; Rabbits; Receptors, Histamine; Thiazoles | 1995 |
Dopamine D2 autoreceptors in rats are behaviorally functional at 21 but not 10 days of age.
Topics: Aging; Aminoquinolines; Animals; Apomorphine; Azepines; Behavior, Animal; Benzothiazoles; Dopamine Agonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Male; Motor Activity; Piperidines; Pramipexole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Thiazoles | 1994 |
Behavioral and neurochemical data suggest functional differences between dopamine D2 and D3 receptors.
Topics: Analysis of Variance; Animals; Apomorphine; Benzothiazoles; CHO Cells; Cricetinae; Cricetulus; Dihydroxyphenylalanine; Dopamine Agonists; Dose-Response Relationship, Drug; Ergolines; Male; Microdialysis; Mitogens; Motor Activity; Piperidines; Pramipexole; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Tetrahydronaphthalenes; Thiazoles; Transfection | 1994 |
Activity of the new histamine H2-receptor antagonist zolantidine at cardiac and gastric H2-receptors.
Topics: Animals; Benzothiazoles; Cats; Female; Gastric Fistula; Gastric Mucosa; Guinea Pigs; Heart Rate; Histamine H2 Antagonists; Male; Myocardial Contraction; Phenoxypropanolamines; Piperidines; Ranitidine; Rats; Rats, Wistar; Thiazoles | 1994 |
Activation of noradrenergic neurons projecting to the diencephalon following central administration of histamine is mediated by H1 receptors.
Topics: Animals; Benzothiazoles; Cerebral Ventricles; Diencephalon; Histamine; Histamine H2 Antagonists; Injections, Intraventricular; Male; Methoxyhydroxyphenylglycol; Neurons; Norepinephrine; Paraventricular Hypothalamic Nucleus; Phenoxypropanolamines; Piperidines; Preoptic Area; Pyrilamine; Rats; Receptors, Histamine H1; Thiazoles | 1994 |
Effects of R 56865 on postischemic ventricular function in isolated rat working heart preparations obtained from healthy, diabetic and hypertensive animals.
Topics: Animals; Benzothiazoles; Blood Glucose; Blood Pressure; Body Weight; Calcium Channel Blockers; Cardiac Output; Coronary Circulation; Diabetes Mellitus, Experimental; Heart; Heart Ventricles; Hypertension; In Vitro Techniques; Male; Myocardial Ischemia; Piperidines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Wistar; Thiazoles; Ventricular Function; Ventricular Pressure | 1994 |
Effects of substrate-free anoxia and veratridine on intracellular calcium concentration in isolated rat ventricular cardiomyocytes.
Topics: Animals; Benzothiazoles; Calcium; Calcium Channel Blockers; Cell Hypoxia; Cell Separation; Cell Size; Male; Microscopy, Fluorescence; Myocardial Contraction; Myocardium; Piperidines; Rats; Rats, Wistar; Sodium; Thiazoles; Veratridine | 1994 |
Effects of antihistaminics on experimental brain edema.
Topics: Animals; Antioxidants; Benzothiazoles; Blood-Brain Barrier; Brain Edema; Dexamethasone; Freezing; Histamine; Histamine Antagonists; Histamine H2 Antagonists; Lipid Peroxidation; Male; Parietal Lobe; Phenoxypropanolamines; Piperidines; Pregnatrienes; Pyrilamine; Rats; Rats, Sprague-Dawley; Thiazoles; Water-Electrolyte Balance | 1994 |
New 4-arylaminopiperidines with antihypoxic and anticonvulsive activity.
Topics: Animals; Anticonvulsants; Cell Survival; Cyanides; Hypoxia; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Piperidines; Seizures; Thiazoles | 1994 |
[Trichomonacidal activity of newly synthesized derivatives of benzoizothiazolinon (BIT) in vitro].
Topics: Acetamides; Animals; Antitrichomonal Agents; In Vitro Techniques; Metronidazole; Piperidines; Species Specificity; Thiazoles; Trichomonas; Trichomonas vaginalis | 1994 |
Sodium channel blockade reduces hypoxic sodium loading and sodium-dependent calcium loading.
Topics: Amiloride; Animals; Benzofurans; Benzothiazoles; Calcium; Calcium Channel Blockers; Cell Separation; Ethers, Cyclic; Fluorescent Dyes; Hypoxia; Lidocaine; Myocardial Contraction; Myocardium; Piperidines; Rats; Sodium; Sodium Channel Blockers; Sodium-Hydrogen Exchangers; Tetrodotoxin; Thiazoles | 1994 |
Aggravation of ischemic neuronal damage in the rat hippocampus by impairment of histaminergic neurotransmission.
Topics: Animals; Benzothiazoles; Brain Ischemia; Cell Death; Hippocampus; Histamine Agonists; Histamine H1 Antagonists; Histamine H2 Antagonists; Male; Methylhistamines; Methylhistidines; Neurons; Phenoxypropanolamines; Piperidines; Pyrilamine; Rats; Rats, Wistar; Receptors, Histamine; Synaptic Transmission; Thiazoles | 1993 |
Effects of several partial dopamine D2 receptor agonists in Cebus apella monkeys previously treated with haloperidol.
Topics: Administration, Oral; Amphetamine; Animals; Antipsychotic Agents; Behavior, Animal; Benzothiazoles; Cebus; Disease Models, Animal; Dopamine Agents; Dopamine D2 Receptor Antagonists; Dyskinesia, Drug-Induced; Dystonia; Ergolines; Female; Haloperidol; Lisuride; Male; Piperidines; Pramipexole; Quinpirole; Raclopride; Salicylamides; Thiazoles | 1993 |
Effects of R-56865 on transient inward current, Na(+)-Ca2+ exchange, and Ca2+ release from SR in cardiac myocytes.
Topics: Animals; Benzothiazoles; Calcium; Calcium Channel Blockers; Carrier Proteins; Cells, Cultured; Guinea Pigs; Heart; Kinetics; Membrane Potentials; Myocardium; Piperidines; Sarcoplasmic Reticulum; Sodium; Sodium-Calcium Exchanger; Thiazoles; Time Factors | 1994 |
R56865, a Na(+)- and Ca(2+)-overload inhibitor, reduces myocardial ischemia-reperfusion injury in blood-perfused rabbit hearts.
Topics: Animals; Benzothiazoles; Blood; Calcium; Energy Metabolism; Heart; Myocardial Reperfusion Injury; Myocardium; Perfusion; Piperidines; Rabbits; Sodium; Thiazoles; Ventricular Function, Left | 1993 |
R56865, an antiarrhythmic drug with class III effects that terminates ouabain induced ventricular tachycardia in an inverse rate dependent manner.
Topics: Animals; Anti-Arrhythmia Agents; Benzothiazoles; Dogs; Dose-Response Relationship, Drug; Female; Heart Rate; Hemodynamics; Male; Ouabain; Piperidines; Tachycardia; Thiazoles | 1993 |
R 56865 delays cellular electrical uncoupling in ischemic rabbit papillary muscle.
Topics: Action Potentials; Animals; Benzothiazoles; Calcium; Heart Conduction System; In Vitro Techniques; Myocardial Contraction; Myocardial Ischemia; Piperidines; Rabbits; Thiazoles | 1993 |
Interference of N-(1-[4-(4-fluorophenoxy)butyl]-piperidinyl)-N-methyl- 2-benzothiazolamine with Na+/H+ exchange and Na+/Ca2+ exchange in purified cardiac sarcolemmal membranes.
Topics: Amiloride; Animals; Benzothiazoles; Calcium; Cattle; Heart; Hydrogen; In Vitro Techniques; Ion Exchange; Membranes; Myocardial Reperfusion; Myocardium; Ouabain; Piperidines; Sarcolemma; Sodium; Thiazoles | 1993 |
R56865 inhibits catecholamine release from bovine chromaffin cells by blocking calcium channels.
Topics: Animals; Benzothiazoles; Calcium; Calcium Channel Blockers; Calcium Channels; Catecholamines; Cattle; Chromaffin System; Cytosol; Electroporation; Homeostasis; Piperidines; Potassium; Thiazoles | 1993 |
R56865 as Ca(2+)-channel blocker in Purkinje neurons of rat: comparison with flunarizine and nimodipine.
Topics: Animals; Benzothiazoles; Calcium Channel Blockers; Electrophysiology; Evoked Potentials; Flunarizine; In Vitro Techniques; Nimodipine; Piperidines; Purkinje Cells; Rats; Rats, Wistar; Thiazoles | 1993 |
R56865 and flunarizine as Na(+)-channel blockers in isolated Purkinje neurons of rat cerebellum.
Topics: Animals; Benzothiazoles; Calcium Channel Blockers; Cerebellum; Electric Stimulation; Electrophysiology; Flunarizine; In Vitro Techniques; Piperidines; Purkinje Cells; Rats; Rats, Wistar; Sodium Channels; Tetrodotoxin; Thiazoles | 1993 |
[EMG findings in patients with diabetic polyneuropathy treated with sabeluzole].
Topics: Diabetes Mellitus, Type 2; Diabetic Neuropathies; Electromyography; Humans; Piperidines; Thiazoles | 1993 |
[Sabeluzole and flunarizine in memory processes: animal studies].
Topics: Animals; Chlordiazepoxide; Flunarizine; Habituation, Psychophysiologic; Male; Memory; Piperidines; Rats; Thiazoles | 1993 |
The effect of diabetes on sexual behavior and reproductive tract function in male rats.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Epididymis; Male; Muscle Contraction; Muscle, Smooth; Organ Size; Piperidines; Rats; Sexual Behavior, Animal; Sperm Count; Sperm Motility; Streptozocin; Testis; Testosterone; Thiazoles; Urinary Bladder | 1993 |
Chronic sabeluzole treatment of cultured rat cerebellar granule cells reduces N-methyl-D-aspartate-induced inward current.
Topics: Animals; Cells, Cultured; Cerebellum; Membrane Potentials; N-Methylaspartate; Piperidines; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Thiazoles | 1993 |
[Flunarizine and sabeluzole improves behavior disorders caused by cold-induced cortical lesions in mice].
Topics: Animals; Behavior, Animal; Cerebral Cortex; Female; Flunarizine; Freezing; Mice; Piperidines; Thiazoles | 1993 |
Inhibition of Na+/Ca2+ overload with R 56,865 protects against cardiac arrhythmias elicited by ouabain in vivo in guinea-pigs.
Topics: Animals; Arrhythmias, Cardiac; Benzothiazoles; Blood Pressure; Calcium; Electrocardiography; Guinea Pigs; Heart Rate; Lidocaine; Male; Ouabain; Piperidines; Sodium; Tetrodotoxin; Thiazoles; Verapamil | 1993 |
R56865 is antifibrillatory in reperfused ischemic guinea-pig hearts, even when given only during reperfusion.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Benzothiazoles; Calcium; Calcium Channel Blockers; Extracellular Space; Guinea Pigs; Heart; In Vitro Techniques; Lidocaine; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Piperidines; Potassium; Sodium; Thiazoles; Verapamil | 1995 |
Does histamine stimulate cyclic AMP formation in the avian pineal gland via a novel (non-H1, non-H2, non-H3) histamine receptor subtype.
Topics: Animals; Benzothiazoles; Chickens; Cyclic AMP; Ducks; Histamine; Histamine Agonists; Histamine H2 Antagonists; Ion Channels; Male; Methylation; Phenoxypropanolamines; Pineal Gland; Piperidines; Receptors, Histamine; Stimulation, Chemical; Thiazoles | 1995 |
Nature of the cardiomyocyte injury induced by lipid hydroperoxides.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Action Potentials; Amlodipine; Animals; Benzothiazoles; Calcium; Calcium Channel Blockers; Cells, Cultured; Dose-Response Relationship, Drug; Free Radical Scavengers; Free Radicals; Guinea Pigs; L-Lactate Dehydrogenase; Leukotrienes; Lipid Peroxides; Membrane Potentials; Myocardium; Necrosis; Piperidines; Rats; Rats, Wistar; Respiratory Burst; Ryanodine; Thiazoles; Vasoconstrictor Agents | 1995 |
In vivo effects of a novel calcium antagonist (R56865) against induced epoxyscillirosidin and tulp poisoning in sheep.
Topics: Animals; Benzothiazoles; Bufanolides; Calcium Channel Blockers; Cholenes; In Vitro Techniques; Piperidines; Plant Extracts; Plant Poisoning; Sheep; Sheep Diseases; Thiazoles; Toxins, Biological | 1995 |
Effects of the antihypoxic and neuroprotective drug, lubeluzole, on repolarization phase of canine heart assessed by monophasic action potential recording.
Topics: Action Potentials; Animals; Blood Pressure; Cardiac Catheterization; Cardiovascular Agents; Disease Models, Animal; Dogs; Electrocardiography; Heart; Heart Rate; Injections, Intravenous; Microelectrodes; Myocardium; Neuroprotective Agents; Piperidines; Rats; Thiazoles | 1996 |
Histamine H3 receptor inhibition of K(+)-evoked release of acetylcholine from rat cortex in vivo.
Topics: Acetylcholine; Analysis of Variance; Animals; Chromatography, High Pressure Liquid; Dimaprit; Histamine; Histamine Agonists; Histamine Antagonists; Male; Methylhistamines; Microdialysis; Neurons; Parietal Lobe; Piperidines; Potassium; Rats; Rats, Wistar; Receptors, Histamine H3; Thiazoles | 1996 |
Preclinical profile of the mixed 5-HT1A/5-HT2A receptor antagonist S 21,357.
Topics: Adenylyl Cyclases; Animals; Anti-Anxiety Agents; Avoidance Learning; Behavior, Animal; Benzothiazoles; Brain Chemistry; Dose-Response Relationship, Drug; Electrophysiology; In Vitro Techniques; Male; Mice; Motor Activity; Piperidines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Antagonists; Synaptic Transmission; Thiazoles | 1996 |
Analogues of sabeluzole with gastric acid secretion inhibitory effect.
Topics: Animals; Anti-Ulcer Agents; Female; Gastric Acid; Piperidines; Rats; Rats, Wistar; Thiazoles | 1996 |
Combined neuroprotection and reperfusion therapy for stroke. Effect of lubeluzole and diaspirin cross-linked hemoglobin in experimental focal ischemia.
Topics: Animals; Aspirin; Cardiovascular Agents; Cerebral Infarction; Cerebrovascular Disorders; Drug Therapy, Combination; Hemodilution; Hemoglobins; Male; Neuroprotective Agents; Piperidines; Rats; Rats, Inbred Strains; Reperfusion; Thiazoles | 1996 |
The actions of ouabain and lithium chloride on cytosolic Ca2+ in single chromaffin cells.
Topics: Adrenal Glands; Animals; Antimanic Agents; Benzothiazoles; Calcium; Calcium Channel Blockers; Calcium Channels; Cattle; Cell Membrane; Cells, Cultured; Chromaffin System; Enzyme Inhibitors; Lithium Chloride; omega-Conotoxins; Ouabain; Peptides; Piperidines; Sodium; Sodium-Potassium-Exchanging ATPase; Thiazoles; Veratridine | 1996 |
Treatment of experimental focal ischemia in rats with lubeluzole.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Neuroprotective Agents; Piperidines; Rats; Thiazoles | 1996 |
Circadian rhythm photic phase shifts are not altered by histamine receptor antagonists.
Topics: Animals; Benzothiazoles; Cimetidine; Circadian Rhythm; Cricetinae; Histamine Antagonists; Histamine H1 Antagonists; Histamine H2 Antagonists; Male; Mesocricetus; Phenoxypropanolamines; Photoperiod; Piperidines; Pyrilamine; Receptors, Histamine H3; Thiazoles | 1996 |
Lubeluzole protects sensorimotor function and reduces infarct size in a photochemical stroke model in rats.
Topics: Animals; Brain; Cerebral Cortex; Cerebral Infarction; Dizocilpine Maleate; Dose-Response Relationship, Drug; Male; Neuroprotective Agents; Nimodipine; Nitric Oxide Synthase; Photochemistry; Piperidines; Rats; Rats, Wistar; Stereoisomerism; Thiazoles | 1996 |
Lubeluzole, a novel long-term neuroprotectant, inhibits the glutamate-activated nitric oxide synthase pathway.
Topics: Animals; Arginine; Cells, Cultured; Cyclic GMP; Glutamic Acid; Guanylate Cyclase; Hippocampus; Interferon-gamma; Lipopolysaccharides; Neuroprotective Agents; Nitric Oxide Synthase; Piperidines; Rats; Stereoisomerism; Thiazoles | 1996 |
Neuroprotection of lubeluzole is mediated through the signal transduction pathways of nitric oxide.
Topics: Animals; Cell Death; Ischemic Preconditioning; Neurons; Neuroprotective Agents; Nitric Oxide; Piperidines; Rats; Rats, Sprague-Dawley; Signal Transduction; Thiazoles | 1997 |
Altered Na(+)-channel function as an in vitro model of the ischemic penumbra: action of lubeluzole and other neuroprotective drugs.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Cerebral Infarction; Cerebrovascular Circulation; Extracellular Space; Guinea Pigs; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Microelectrodes; Neuroprotective Agents; Piperidines; Pyramidal Cells; Sodium Channels; Thiazoles; Veratridine | 1997 |
Protection with lubeluzole against delayed ischemic brain damage in rats. A quantitative histopathologic study.
Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Carotid Stenosis; Cell Death; Drug Evaluation, Preclinical; Hippocampus; Ligation; Male; Neurons; Neuroprotective Agents; Piperidines; Rats; Rats, Wistar; Shock; Thiazoles; Time Factors | 1997 |
Pharmacological reduction of electrophysiological diaschisis after photothrombotic ischemia in rat neocortex.
Topics: Animals; Cerebral Cortex; Dermatitis, Phototoxic; Disease Models, Animal; Dizocilpine Maleate; Electrophysiology; Evoked Potentials; Excitatory Amino Acid Antagonists; Intracranial Embolism and Thrombosis; Ischemic Attack, Transient; Male; Neuroprotective Agents; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Thiazoles | 1997 |
Priming of cultured neurons with sabeluzole results in long-lasting inhibition of neurotoxin-induced tau expression and cell death.
Topics: Animals; Cell Death; Dose-Response Relationship, Drug; Glutamic Acid; Humans; Neurons; Piperidines; Rats; Rats, Sprague-Dawley; tau Proteins; Thiazoles; Time Factors | 1997 |
Effects of histamine agents on methamphetamine-induced stereotyped behavior and behavioral sensitization in rats.
Topics: Animals; Benzothiazoles; Brain; Central Nervous System Stimulants; Histamine Agents; Histidine; Male; Methamphetamine; Methylhistidines; Motor Activity; Phenoxypropanolamines; Piperidines; Pyrilamine; Rats; Rats, Wistar; Receptors, Histamine; Stereotyped Behavior; Thiazoles | 1997 |
In vitro inhibition of heparin-induced platelet aggregation in plasma from patients with HIT by SR 121566, a newly developed Gp IIb/IIIa antagonist.
Topics: Benzylamines; Heparin; Humans; In Vitro Techniques; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thiazoles; Thrombocytopenia | 1997 |
Interactions between neuronal histamine and halothane anesthesia in rats.
Topics: Anesthetics, Inhalation; Animals; Benzothiazoles; Drug Interactions; Enzyme Inhibitors; Halothane; Histamine Antagonists; Histamine H1 Antagonists; Histamine H2 Antagonists; Histamine Release; Male; Methylhistidines; Microdialysis; Neurons; Phenoxypropanolamines; Piperidines; Pyrilamine; Rats; Rats, Sprague-Dawley; Thiazoles | 1997 |
Characterization of potential antagonists of human interleukin 5 demonstrates their cross-reactivity with receptors for interleukin 3 and granulocyte-macrophage colony-stimulating factor.
Topics: Animals; Antigens, CD; Biosensing Techniques; Cell Division; Cross Reactions; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-3; Interleukin-5; Mice; Phenols; Piperidines; Receptors, Interleukin; Receptors, Interleukin-3; Receptors, Interleukin-4; Receptors, Interleukin-5; Recombinant Proteins; Solubility; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spodoptera; Thiazoles; Tumor Cells, Cultured | 1997 |
Synthesis and pharmacological activity of 2-(substituted phenyl)-3-[2 or 3-[(4-substituted phenyl-4-hydroxy)piperidino]ethyl or propyl]-1,3-thiazolidin-4-ones.
Topics: Animals; Antidiarrheals; Male; Mice; Molecular Structure; Piperidines; Thiazoles | 1997 |
Effects of clobenpropit (VUF-9153), a histamine H3-receptor antagonist, on learning and memory, and on cholinergic and monoaminergic systems in mice.
Topics: Acetylcholine; Animals; Avoidance Learning; Benzothiazoles; Biogenic Monoamines; Brain; Drug Interactions; Histamine Antagonists; Histamine H2 Antagonists; Imidazoles; Male; Memory; Methylhistamines; Mice; Mice, Inbred ICR; Phenoxypropanolamines; Piperidines; Pyrilamine; Receptors, Histamine H1; Receptors, Histamine H3; Scopolamine; Thiazoles; Thiourea | 1997 |
Antiplatelet and antithrombotic efficacy of SR 121787, a nonpeptide orally active GP IIb/IIIa antagonist, in rabbits: comparison with clopidogrel and aspirin.
Topics: Animals; Aspirin; Benzylamines; Clopidogrel; Hemodynamics; Hemostasis; Male; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Rabbits; Thiazoles; Thrombosis; Ticlopidine | 1997 |
Differential effects of the neuroprotectant lubeluzole on bovine and mouse chromaffin cell calcium channel subtypes.
Topics: Animals; Barium; Calcium Channel Blockers; Cattle; Chromaffin Cells; Mice; Neuroprotective Agents; Patch-Clamp Techniques; Piperidines; Stereoisomerism; Thiazoles | 1997 |
New orally active non-peptide fibrinogen receptor (GpIIb-IIIa) antagonists: identification of ethyl 3-[N-[4-[4-[amino[(ethoxycarbonyl) imino]methyl]phenyl]-1,3-thiazol-2-yl]-N-[1-[(ethoxycarbonyl)methyl]pip erid -4-yl]amino]propionate (SR 121787) as a pot
Topics: Adenosine Diphosphate; Administration, Oral; Animals; Benzylamines; Fibrinogen; Fibrinolytic Agents; Humans; Molecular Structure; Papio; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Thiazoles | 1997 |
Extracellular changes of taurine in the peri-infarct zone: effect of lubeluzole.
Topics: Animals; Cerebral Infarction; Male; Neuroprotective Agents; Piperidines; Rats; Rats, Wistar; Stereoisomerism; Taurine; Thiazoles | 1997 |
Lubeluzole blocks increases in extracellular glutamate and taurine in the peri-infarct zone in rats.
Topics: Animals; Blood Pressure; Cerebral Infarction; Cortical Spreading Depression; Glutamic Acid; Glutamine; Heart Rate; Male; Neocortex; Neuroprotective Agents; Piperidines; Rats; Rats, Wistar; Taurine; Thiazoles | 1997 |
Q-type Ca2+ channels are located closer to secretory sites than L-type channels: functional evidence in chromaffin cells.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Catecholamines; Cattle; Chromaffin Cells; Dihydropyridines; In Vitro Techniques; Neurosecretory Systems; omega-Agatoxin IVA; omega-Conotoxin GVIA; Peptides; Piperidines; Potassium; Spider Venoms; Thiazoles | 1998 |
Effect of SR121566A, a potent GP IIb-IIIa antagonist on platelet-mediated thrombin generation in vitro and in vivo.
Topics: Animals; Aspirin; Benzylamines; Blood Platelets; Cells, Cultured; Humans; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Rabbits; Thiazoles; Thrombin | 1998 |
Effect of glycoprotein IIb/IIIa antagonists on the HIT serum induced activation of platelets.
Topics: Benzylamines; Blood Platelets; Blood Proteins; Drug Interactions; Heparin; Humans; Immunoglobulin Fab Fragments; Piperidines; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thiazoles; Thrombocytopenia | 1997 |
Lubeluzole protects hippocampal neurons from excitotoxicity in vitro and reduces brain damage caused by ischemia.
Topics: Animals; Animals, Newborn; Astrocytes; Brain Ischemia; Cells, Cultured; Excitatory Amino Acids; Glutamic Acid; Hippocampus; Male; Mice; Neurons; Neuroprotective Agents; Piperidines; Rats; Rats, Inbred F344; Stereoisomerism; Thiazoles | 1998 |
Motor behavioural function for histamine-dopamine interaction in brain.
Topics: Animals; Benzazepines; Benzothiazoles; Brain; Brain Chemistry; Central Nervous System Stimulants; Dopamine Agents; Dopamine Antagonists; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonists; Histidine; Methamphetamine; Motor Activity; Phenoxypropanolamines; Piperidines; Pyrilamine; Rats; Rats, Wistar; Stereotyped Behavior; Thiazoles | 1998 |
M1 muscarinic agonist treatment reverses cognitive and cholinergic impairments of apolipoprotein E-deficient mice.
Topics: Acetylcholinesterase; Animals; Apolipoproteins E; Brain; Choline O-Acetyltransferase; Cholinergic Fibers; Cognition; Cognition Disorders; Male; Maze Learning; Mice; Mice, Knockout; Muscarinic Agonists; Piperidines; Reaction Time; Swimming; Thiazoles | 1998 |
A novel histamine 2(H2) receptor antagonist with gastroprotective activity. I. Synthesis and pharmacological evaluation of N-phenoxypropylacetamide derivatives with thioether function.
Topics: Acetamides; Administration, Oral; Animals; Anti-Ulcer Agents; Benzothiazoles; Calcium Channel Blockers; Gastric Acid; Histamine H2 Antagonists; Male; Perfusion; Piperidines; Rats; Rats, Wistar; Stomach; Structure-Activity Relationship; Sulfides; Thiazoles | 1998 |
The protective effects of CP-060S on ischaemia- and reperfusion- induced arrhythmias in anaesthetized rats.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzothiazoles; Calcium Channel Blockers; Diltiazem; Hemodynamics; Male; Myocardial Ischemia; Myocardial Reperfusion; Piperidines; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidines | 1998 |
Epileptiform discharges to extracellular stimuli in rat neocortical slices after photothrombotic infarction.
Topics: Animals; Cerebral Infarction; Dizocilpine Maleate; Electric Stimulation; Electrophysiology; Epilepsy; In Vitro Techniques; Intracranial Embolism and Thrombosis; Light; Male; Neocortex; Neuroprotective Agents; Piperidines; Rats; Rats, Wistar; Reaction Time; Thiazoles | 1998 |
Late sodium current inhibition in human isolated cardiomyocytes by R 56865.
Topics: Benzothiazoles; Calcium Channel Blockers; Dose-Response Relationship, Drug; Heart Atria; Humans; Patch-Clamp Techniques; Piperidines; Sodium Channel Blockers; Sodium Channels; Thiazoles | 1998 |
Lubeluzole treatment of acute ischemic stroke.
Topics: Acute Disease; Brain Ischemia; Cardiovascular Agents; Cerebrovascular Disorders; Humans; Piperidines; Thiazoles | 1998 |
Does neuroprotection improve stroke outcome?
Topics: Cerebrovascular Disorders; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Neuroprotective Agents; Piperidines; Randomized Controlled Trials as Topic; Research Design; Thiazoles; Thrombolytic Therapy; Time Factors; Treatment Outcome | 1998 |
Influence of lubeluzole on voltage-sensitive Ca++ channels in isolated rat neurons.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dose-Response Relationship, Drug; Ganglia, Spinal; Male; Neuroprotective Agents; Piperidines; Rats; Rats, Wistar; Stereoisomerism; Thiazoles | 1998 |
Cognitive involvement by negative modulation of histamine H2 receptors in passive avoidance task in mice.
Topics: Animals; Avoidance Learning; Benzothiazoles; Cognition; Drug Interactions; Histamine Agonists; Histamine H2 Antagonists; Injections, Intraventricular; Male; Memory; Methylhistamines; Mice; Mice, Inbred ICR; Phenoxypropanolamines; Piperidines; Receptors, Histamine H2; Thiazoles | 1998 |
Prevention of thrombosis and enhancement of thrombolysis in rabbits by SR 121787, a glycoprotein II/III antagonist.
Topics: Animals; Aspirin; Benzylamines; Bleeding Time; Carotid Artery Injuries; Collagen; Fibrinolytic Agents; Hemostasis; In Vitro Techniques; Jugular Veins; Male; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Rabbits; Thiazoles; Thrombocytopenia; Thrombosis | 1998 |
Effects of the neuroprotectant lubeluzole on the cytotoxic actions of veratridine, barium, ouabain and 6-hydroxydopamine in chromaffin cells.
Topics: Adrenal Glands; Animals; Barium; Calcium; Cattle; Chromaffin Cells; Cytosol; Neuroprotective Agents; Ouabain; Oxidopamine; Penfluridol; Piperidines; Sodium; Thiazoles; Veratridine | 1998 |
Early phosphorylation events induced by DPIV/CD26-specific inhibitors.
Topics: Calcium; CD3 Complex; Cyclic AMP; Dipeptidyl Peptidase 4; Humans; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Lysine; Mitogens; Phosphorylation; Piperidines; Protease Inhibitors; Protein Kinase C; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thiazoles; Tyrosine | 1998 |
SR 121787, a new orally active fibrinogen receptor antagonist.
Topics: Administration, Oral; Animals; Benzylamines; Humans; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prodrugs; Rabbits; Thiazoles | 1998 |
4,4-Disubstituted piperidine high-affinity NK1 antagonists: structure-activity relationships and in vivo activity.
Topics: Animals; Capillary Permeability; CHO Cells; Cricetinae; Diterpenes; Esophagus; Guinea Pigs; Inositol Phosphates; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Pyrrolidines; Radioligand Assay; Receptors, Neurokinin-1; Structure-Activity Relationship; Thiazoles | 1998 |
Effects of a new platelet glycoprotein IIb/IIIa antagonist, SR121566, on platelet activation, platelet-leukocyte interaction and thrombin generation.
Topics: Adenosine Diphosphate; Adult; Aged; Benzylamines; Blood Platelets; Cell Aggregation; Female; Fibrinogen; Flow Cytometry; Humans; Iodine Radioisotopes; Leukocytes; Male; Middle Aged; Piperidines; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thiazoles; Thrombin | 1998 |
Generalization of D-, L- and DL-chlorpheniramine and zolantidine to the discriminative stimulus effects of cocaine and methamphetamine.
Topics: Animals; Antidepressive Agents, Tricyclic; Benzothiazoles; Chlorpheniramine; Clomipramine; Cocaine; Desipramine; Discrimination, Psychological; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Generalization, Stimulus; Histamine H1 Antagonists; Histamine H2 Antagonists; Humans; Male; Methamphetamine; Middle Aged; Phenoxypropanolamines; Piperazines; Piperidines; Rats; Rats, Inbred F344; Thiazoles | 1997 |
Alterations in tau phosphorylation in rat and human neocortical brain slices following hypoxia and glucose deprivation.
Topics: Animals; Brain Ischemia; Cell Hypoxia; Enzyme Inhibitors; Glucose; Humans; Hypoglycemia; Hypoxia, Brain; Male; Neocortex; Neuroprotective Agents; Okadaic Acid; Organ Culture Techniques; Phosphorylation; Piperidines; Precipitin Tests; Rats; Rats, Sprague-Dawley; tau Proteins; Temporal Lobe; Thiazoles | 1998 |
Site-specific dephosphorylation of tau of apolipoprotein E-deficient and control mice by M1 muscarinic agonist treatment.
Topics: Animals; Antibodies, Monoclonal; Apolipoproteins E; Blotting, Western; Brain Chemistry; Epitopes; Male; Mice; Mice, Knockout; Muscarinic Agonists; Phosphorylation; Piperidines; Receptor, Muscarinic M1; Receptors, Muscarinic; tau Proteins; Thiazoles | 1999 |
Neuroprotective action of a novel compound--M50463--in primary cultured neurons.
Topics: Acetylcysteine; Animals; Antihypertensive Agents; Batrachotoxins; Binding Sites; Binding, Competitive; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cell Death; Cells, Cultured; Culture Media, Serum-Free; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Indoles; Neurons; Neuroprotective Agents; Neurotoxins; Nicardipine; Nitroprusside; Piperidines; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Sodium Channels; Thiazoles; Veratrine; Vitamin E | 1999 |
Ischemia/reperfusion-induced arrhythmias in anaesthetized rats: a role of Na+ and Ca2+ influx.
Topics: Amiloride; Anesthesia; Animals; Arrhythmias, Cardiac; Benzothiazoles; Blood Pressure; Calcium; Calcium Channel Blockers; Calcium Channels; Heart Rate; Lidocaine; Male; Myocardial Reperfusion Injury; Piperidines; Rats; Rats, Wistar; Sodium; Sodium Channel Blockers; Sodium Channels; Thiazoles; Verapamil | 1999 |
Effects of histamine H2 receptor agonists and antagonists on the isolated guinea pig gallbladder.
Topics: Animals; Benzothiazoles; Dopamine Agents; Famotidine; Gallbladder; Guanidines; Guinea Pigs; Histamine; Histamine Agonists; Histamine H2 Antagonists; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Phenoxypropanolamines; Piperidines; Pyridines; Receptors, Histamine H2; Sincalide; Thiazoles; Triazoles | 1999 |
The anti-ischemic effects of CP-060S during pacing-induced ischemia in anesthetized dogs.
Topics: Anesthesia; Animals; Benzothiazoles; Calcium Channel Blockers; Coronary Vessels; Diltiazem; Dogs; Drug Synergism; Electrocardiography; Ischemia; Male; Piperidines; Thiazoles; Thiazolidines | 1999 |
Novel structural templates for estrogen-receptor ligands and prospects for combinatorial synthesis of estrogens.
Topics: Binding Sites; Estradiol; Estrogen Antagonists; Estrogens; Imidazoles; Isoxazoles; Ligands; Models, Molecular; Oxazoles; Piperidines; Protein Conformation; Pyrazoles; Raloxifene Hydrochloride; Receptors, Estrogen; Thiazoles; X-Ray Diffraction | 1999 |
The antithrombotic efficacy of the GP IIb/IIIa antagonist SR121787 is potentiated by antithrombin-dependent factor Xa inhibition without an increase in the bleeding risk in the rabbit.
Topics: Animals; Anticoagulants; Antithrombins; Benzylamines; Carotid Arteries; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Factor Xa Inhibitors; Fibrinolytic Agents; Hemorrhage; Heparin; Male; Oligosaccharides; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Rabbits; Thiazoles | 1999 |
Effects of the antihistaminergic drugs diphenhydramine and zolantidine on vestibular-induced hypothalamic neuronal activity in the guinea pig.
Topics: Animals; Benzothiazoles; Caloric Tests; Diphenhydramine; Guinea Pigs; Histamine H1 Antagonists; Hypothalamus; Injections, Intravenous; Male; Neurons; Phenoxypropanolamines; Piperidines; Thiazoles; Vestibule, Labyrinth | 1999 |
Solution-phase and solid-phase synthesis of novel transition state inhibitors of coagulation enzymes incorporating a piperidinyl moiety.
Topics: Blood Coagulation Factors; Carboxylic Acids; Factor Xa Inhibitors; Inhibitory Concentration 50; Kinetics; Models, Chemical; Piperidines; Platelet Glycoprotein GPIIb-IIIa Complex; Thiazoles; Thrombin | 1999 |
Histamine H2-receptor modulation in two mouse models of seizure susceptibility.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Benzothiazoles; Convulsants; Dimaprit; Female; Histamine Agonists; Histamine Antagonists; Male; Mice; Mice, Inbred DBA; Pentylenetetrazole; Phenoxypropanolamines; Piperidines; Receptors, Histamine H2; Seizures; Thiazoles | 1999 |
Interspecies comparison of the antiplatelet, antithrombotic, and hemorrhagic effects of SR 121566A, a novel nonpeptide GP IIb/IIIa antagonist.
Topics: Adenosine Diphosphate; Animals; Arteriovenous Shunt, Surgical; Benzylamines; Dogs; Fibrinolytic Agents; Guinea Pigs; Hemorrhage; Humans; In Vitro Techniques; Male; Mice; Papio; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Rabbits; Rats; Species Specificity; Thiazoles | 1999 |
A Na+-activated K+ current (IK,Na) is present in guinea-pig but not rat ventricular myocytes.
Topics: Animals; Benzothiazoles; Calcium; Calcium Channel Blockers; Diltiazem; Electric Conductivity; Glyburide; Guinea Pigs; Heart; Magnesium; Male; Membrane Potentials; Patch-Clamp Techniques; Piperidines; Potassium; Potassium Channels; Rats; Rats, Sprague-Dawley; Sodium; Sodium-Potassium-Exchanging ATPase; Thiazoles; Ventricular Function | 1999 |
Effects of NRA0045, NRA0160, and NRA0215 on regional Fos-like immunoreactivity in the rat brain.
Topics: Animals; Antipsychotic Agents; Brain Chemistry; Clozapine; Corpus Striatum; Haloperidol; Immunohistochemistry; Male; Nucleus Accumbens; Piperidines; Prefrontal Cortex; Proto-Oncogene Proteins c-fos; Pyrrolidines; Rats; Rats, Wistar; Thiazoles | 1999 |
Lubeluzole following traumatic brain injury in the rat.
Topics: Animals; Blood Gas Analysis; Blood Pressure; Body Water; Brain Edema; Brain Injuries; Enzyme Inhibitors; Intracranial Pressure; Magnetic Resonance Imaging; Male; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Piperidines; Rats; Rats, Sprague-Dawley; Thiazoles; Time Factors | 1999 |
Electrophysiological actions of N-[1-[4-(4-fluorophenoxy)butyl]-4-piperidinyl]-N-methyl-2-benzothiazola mine (R56865) on CA1 neurons of the rat hippocampal slice during hypoxia.
Topics: Animals; Benzothiazoles; Calcium Channel Blockers; Electric Stimulation; Electrophysiology; Hippocampus; Hypoxia; In Vitro Techniques; Neurons; Piperidines; Rats; Reference Values; Synaptic Transmission; Thiazoles | 1999 |
Facilitation of memory performance by a novel muscarinic agonist in young and old rats.
Topics: Aging; Algorithms; Animals; Cognition; Female; Memory; Muscarinic Agonists; Piperidines; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Receptors, Muscarinic; Thiazoles | 1999 |
Bepridil blunts the shortening of action potential duration caused by metabolic inhibition via blockade of ATP-sensitive K(+) channels and Na(+)-activated K(+) channels.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Benzothiazoles; Bepridil; Calcium Channel Blockers; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Dose-Response Relationship, Drug; Glyburide; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Patch-Clamp Techniques; Perfusion; Piperidines; Potassium Channels; Sodium; Thiazoles; Time Factors; Uncoupling Agents | 1999 |
Lubeluzole shows neuroprotective effects in an "in-vitro"-model for neuronal lesions in the chicken retina.
Topics: Animals; Chickens; Electric Stimulation; Electrophysiology; In Vitro Techniques; Neurons; Neuroprotective Agents; Piperidines; Retina; Stereoisomerism; Thiazoles | 1999 |
Lubeluzole. JK 8792, R 87926, Prosynap.
Topics: Acute Disease; Brain Ischemia; Drugs, Investigational; Humans; Neuroprotective Agents; Piperidines; Stroke; Thiazoles | 1999 |
What's new with neuroprotective agents in stroke?
Topics: Animals; Chlormethiazole; Cytidine Diphosphate Choline; Drugs, Investigational; Humans; Neuroprotective Agents; Nootropic Agents; Piperidines; Stroke; Thiazoles | 1999 |
A selective dopamine D4 receptor antagonist, NRA0160: a preclinical neuropharmacological profile.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Brain; Catalepsy; Clozapine; Dopamine D2 Receptor Antagonists; Drug Evaluation, Preclinical; Locomotion; Male; Maze Learning; Methamphetamine; Mice; Mice, Inbred ICR; Piperidines; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D4; Reflex, Startle; Stereotyped Behavior; Swimming; Thiazoles | 1999 |
Effects of selective dopamine D4 receptor blockers, NRA0160 and L-745,870, on A9 and A10 dopamine neurons in rats.
Topics: Animals; Antipsychotic Agents; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Male; Neurons; Piperidines; Pyridines; Pyrroles; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D4; Substantia Nigra; Thiazoles; Ventral Tegmental Area | 1999 |
Pharmacologic management of diabetes mellitus.
Topics: Carbamates; Chromans; Diabetes Mellitus; Humans; Hypoglycemic Agents; Metformin; Piperidines; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Effects of histamine and related compounds on regional cerebral blood flow in rats.
Topics: Animals; Benzothiazoles; Blood Pressure; Brain Chemistry; Dimaprit; Diphenhydramine; Drug Interactions; Hippocampus; Histamine; Histamine Agonists; Histamine Antagonists; Histamine H1 Antagonists; Histamine H2 Antagonists; Histidine; Male; Phenoxypropanolamines; Piperidines; Pyrilamine; Rats; Rats, Wistar; Regional Blood Flow; Thiazoles; Time Factors | 1999 |
Differential in vitro effects of the platelet glycoprotein IIb/IIIa inhibitors abixicimab or SR121566A on platelet aggregation, fibrinogen binding and platelet secretory parameters.
Topics: Adenosine Triphosphate; Adult; Antibodies, Monoclonal; Antigens, CD; Benzylamines; Binding Sites; Blood Platelets; Female; Fibrinogen; Humans; In Vitro Techniques; Male; Oligopeptides; P-Selectin; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Membrane Glycoproteins; Tetraspanin 30; Thiazoles | 2000 |
Membrane asymmetry and DNA degradation: functionally distinct determinants of neuronal programmed cell death.
Topics: Animals; Animals, Newborn; Annexin A5; Apoptosis; Biomarkers; Cell Membrane; Cell Nucleus; DNA; Enzyme Inhibitors; Free Radical Scavengers; Hippocampus; Neurons; Neuroprotective Agents; Nitric Oxide; Phosphatidylserines; Piperidines; Rats; Rats, Sprague-Dawley; Thiazoles; Triazenes | 2000 |
Managing type 2 diabetes. A look at the newer agents.
Topics: Acarbose; Carbamates; Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Piperidines; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
Diffusion-weighted MRI of infarct growth in a rat photochemical stroke model: effect of lubeluzole.
Topics: Animals; Cerebral Infarction; Diffusion; Magnetic Resonance Imaging; Male; Motor Cortex; Neocortex; Neuroprotective Agents; Photochemistry; Piperidines; Rats; Rats, Wistar; Somatosensory Cortex; Thiazoles | 2000 |
Ex vivo--in vitro interaction between aspirin, clopidogrel, and the glycoprotein IIb/IIIa inhibitors abciximab and SR121566A.
Topics: Abciximab; Administration, Oral; Adult; Analysis of Variance; Antibodies, Monoclonal; Aspirin; Benzylamines; Bleeding Time; Clopidogrel; Drug Administration Schedule; Drug Interactions; Fibrinogen; Humans; Immunoglobulin Fab Fragments; Male; Nephelometry and Turbidimetry; P-Selectin; Piperidines; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Reference Values; Thiazoles; Ticlopidine | 2000 |
Critical temporal modulation of neuronal programmed cell injury.
Topics: Animals; Annexin A5; Apoptosis; Biomarkers; Cell Membrane; Cell Survival; DNA Fragmentation; Hippocampus; Molsidomine; Neurons; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Phosphatidylserines; Piperidines; Rats; Rats, Sprague-Dawley; Thiazoles; Vasodilator Agents | 2000 |
Participation of neuropeptides in antigen-induced contraction of guinea pig bronchi via NK(2) but not NK(1) receptor stimulation.
Topics: Animals; Benzamides; Benzeneacetamides; Biphenyl Compounds; Bronchi; Bronchoconstriction; Female; gamma-Globulins; Guinea Pigs; Histamine H1 Antagonists; Leukotriene Antagonists; Male; Neurokinin-1 Receptor Antagonists; Neuropeptides; Penicillin G; Piperidines; Pyrilamine; Receptors, Neurokinin-2; Substance P; Thiazoles; Trachea | 2000 |
Effect of aspirin on platelet desaggregation induced by SR121566, a potent GP-IIb/IIIa antagonist.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Aspirin; Benzylamines; Blood Flow Velocity; Blood Platelets; Carotid Arteries; Disease Models, Animal; Electric Stimulation; Female; Fibrinolytic Agents; Humans; Male; Oligopeptides; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Rabbits; Recombinant Proteins; Thiazoles; Thrombosis; Thrombospondins; Tissue Plasminogen Activator | 2000 |
Site of action of lubeluzole on voltage-sensitive Ca(2+) channels in isolated dorsal root ganglion cells of the rat: influence of pH.
Topics: Animals; Benzothiazoles; Calcium Channel Blockers; Calcium Channels; Electric Stimulation; Ganglia, Spinal; Hydrogen-Ion Concentration; Kinetics; Male; Neurons, Afferent; Neuroprotective Agents; Patch-Clamp Techniques; Piperidines; Rats; Rats, Wistar; Thiazoles | 2000 |
Transient up-regulation of gamma-aminobutyric acid(A) receptor binding by lubeluzole after neocortical specify lesion in rats.
Topics: Animals; Brain Ischemia; Male; Muscimol; Neocortex; Neuroprotective Agents; Photochemistry; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, AMPA; Receptors, GABA-A; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Rose Bengal; Thiazoles; Tritium; Up-Regulation | 2000 |
Evidence for the involvement of diacylglycerol kinase in the activation of hypoxia-inducible transcription factor 1 by low oxygen tension.
Topics: Cell Nucleus; Diacylglycerol Kinase; Diglycerides; DNA; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; HeLa Cells; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Luciferases; Nuclear Proteins; Oxygen; Phosphatidic Acids; Phospholipids; Piperidines; Plasmids; Pyrimidinones; Quinazolines; Quinazolinones; Recombinant Proteins; Signal Transduction; Thiazoles; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection | 2001 |
The effect of a novel glycoprotein IIb/IIIa antagonist, SR 121566A, on platelet aggregation and activation in rhesus monkeys.
Topics: Adenosine Diphosphate; Animals; Benzylamines; Drug Administration Routes; Drug Evaluation, Preclinical; Macaca mulatta; Male; P-Selectin; Piperidines; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thiazoles; Time Factors | 2001 |
Studies on the involvement of histamine in the hypothalamic-pituitary-adrenal axis activation induced by nerve growth factor.
Topics: Adrenal Glands; Animals; Benzothiazoles; Catheterization; Corticosterone; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonists; Hypothalamo-Hypophyseal System; Male; Metiamide; Mice; Nerve Growth Factor; Phenoxypropanolamines; Piperidines; Pituitary-Adrenal System; Promethazine; Rats; Rats, Wistar; Thiazoles | 2000 |
Honing type 2 diabetes treatment.
Topics: Carbamates; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Pioglitazone; Piperidines; Thiazoles; Thiazolidinediones | 2001 |
Effects of lubeluzole on the methamphetamine-induced increase in extracellular glutamate and the long-term depletion of striatal dopamine.
Topics: Animals; Body Temperature; Dopamine; Drug Interactions; Extracellular Space; Glutamic Acid; Male; Methamphetamine; Neostriatum; Neurons; Neuroprotective Agents; Piperidines; Rats; Rats, Sprague-Dawley; Sodium Channels; Thiazoles; Veratridine | 2001 |
Synthesis of the antistroke drug lubeluzole and its enantiomer. Lipase-catalyzed resolution of chiral building block.
Topics: Cardiovascular Agents; Catalysis; Lipase; Piperidines; Propanols; Stereoisomerism; Substrate Specificity; Thiazoles | 2001 |
Lubeluzole inhibits accumulation of extracellular glutamate in the hippocampus during transient global cerebral ischemia.
Topics: Action Potentials; Animals; Body Temperature; Brain Ischemia; Cardiovascular Physiological Phenomena; Extracellular Space; Glutamic Acid; Hippocampus; Microdialysis; Nerve Degeneration; Neurons; Neuroprotective Agents; Piperidines; Rabbits; Reperfusion Injury; Respiratory Physiological Phenomena; Thiazoles | 2001 |
Studies on the binding of 3H-SR121566, an inhibitor of Gp IIb-IIIa activation.
Topics: Abciximab; Antibodies, Monoclonal; Benzylamines; Binding Sites; Binding, Competitive; Blood Cells; Cell Line; Endothelium, Vascular; Fibrinogen; Flow Cytometry; Humans; Immunoglobulin Fab Fragments; Oligopeptides; Organ Specificity; Piperidines; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Conformation; Proteins; Receptors, Thrombin; Thiazoles | 2001 |
Huperzine A and donepezil protect rat pheochromocytoma cells against oxygen-glucose deprivation.
Topics: Alkaloids; Alzheimer Disease; Animals; Cell Size; Cell Survival; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Glucose; Hypoxia-Ischemia, Brain; Indans; Lipid Peroxidation; Malondialdehyde; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Piperidines; Rats; Sesquiterpenes; Superoxide Dismutase; Tetrazolium Salts; Thiazoles | 2001 |
Treatment with inhibitors of caspases, that are substrates of drug transporters, selectively permits chemotherapy-induced apoptosis in multidrug-resistant cells but protects normal cells.
Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Boronic Acids; Bortezomib; Cell Cycle; Cell Survival; Cyclosporins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Fragmentation; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Epothilones; Epoxy Compounds; Flavonoids; Hematopoietic Stem Cells; HL-60 Cells; Humans; Jurkat Cells; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Oligopeptides; Paclitaxel; Piperidines; Poly(ADP-ribose) Polymerases; Pyrazines; Substrate Specificity; Thiazoles | 2001 |
Reduction of cerebrospinal fluid amyloid beta after systemic administration of M1 muscarinic agonists.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cerebrospinal Fluid; Female; Muscarinic Agonists; Neurons; Peptide Fragments; Piperidines; Quinuclidines; Rabbits; Receptor, Muscarinic M1; Receptors, Muscarinic; Thiazoles; Thiophenes | 2001 |
Neuropharmacological profiles of a novel atypical antipsychotic, NRA0562, in rats.
Topics: Action Potentials; Animals; Antipsychotic Agents; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Immunohistochemistry; Male; Methamphetamine; Neurons; Piperidines; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Risperidone; Thiazoles | 2001 |
A new era in type 2 diabetes mellitus treatment?
Topics: 1-Deoxynojirimycin; Acarbose; Carbamates; Diabetes Mellitus, Type 2; Glucosamine; Humans; Hypoglycemic Agents; Imino Pyranoses; Multicenter Studies as Topic; Pioglitazone; Piperidines; Randomized Controlled Trials as Topic; Thiazoles; Thiazolidinediones | 2001 |
Utilization of oral hypoglycemic agents in a drug-insured U.S. population.
Topics: Carbamates; Chromans; Cohort Studies; Databases as Topic; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Insurance, Pharmaceutical Services; Longitudinal Studies; Managed Care Programs; Metformin; Piperidines; Retrospective Studies; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Time Factors; Troglitazone; United States | 2001 |
Facilitating effects of histamine on spatial memory deficit induced by scopolamine in rats.
Topics: Animals; Brain; Histamine; Histamine Agonists; Histamine Antagonists; Histidine; Injections, Intraventricular; Male; Maze Learning; Memory Disorders; Piperidines; Rats; Rats, Wistar; Scopolamine; Thiazoles | 2000 |
Lubeluzole attenuates K(+)-evoked extracellular accumulation of taurine in the striatum of healthy rats and rats with hepatic failure.
Topics: Animals; Extracellular Space; Glutamic Acid; Hepatic Encephalopathy; Male; Microdialysis; Neostriatum; Neurons; Neuroprotective Agents; Osmotic Pressure; Piperidines; Potassium Chloride; Rats; Rats, Wistar; Taurine; Thiazoles; Thioacetamide | 2001 |
Efficacy of antipsychotic agents at human 5-HT(1A) receptors determined by [3H]WAY100,635 binding affinity ratios: relationship to efficacy for G-protein activation.
Topics: Animals; Antipsychotic Agents; Binding, Competitive; Chlorpromazine; CHO Cells; Clozapine; Cricetinae; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Humans; Membranes; Piperazines; Piperidines; Pyridines; Pyrimidinones; Pyrrolidines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Thiazoles; Thioridazine; Tritium | 2001 |
Characterisation of Rac activation in thrombin- and collagen-stimulated human blood platelets.
Topics: Benzylamines; Blood Platelets; Calcium; cdc42 GTP-Binding Protein; Cells, Cultured; Chromones; Collagen; Enzyme Activation; Enzyme Inhibitors; Epoprostenol; Estrenes; Humans; Indoles; Morpholines; Oligopeptides; p21-Activated Kinases; Phosphatidylinositol 3-Kinases; Piperidines; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Kinase C; Protein Serine-Threonine Kinases; Pyrrolidinones; rac GTP-Binding Proteins; Thiazoles; Thrombin; Type C Phospholipases | 2001 |
Putative effect of Helicobacter pylori and gastritis on gastric acid secretion in cat.
Topics: Animals; Anti-Bacterial Agents; Cats; Gastric Acid; Gastric Mucosa; Gastrins; Gastritis; Helicobacter; Helicobacter Infections; Helicobacter pylori; Histamine Antagonists; Kinetics; Pentagastrin; Piperidines; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Histamine H3; Thiazoles; Urease | 2002 |
Lubeluzole pretreatment does not provide neuroprotection against transient global cerebral ischemia in fetal sheep near term.
Topics: Acid-Base Equilibrium; Animals; Blood Gas Analysis; Brain; Brain Ischemia; Cerebrovascular Circulation; Female; Fetal Diseases; Gestational Age; Humans; Neuroprotective Agents; Piperidines; Pregnancy; Sheep; Thiazoles | 2002 |
DNA modification by 4-aza-3-ene-1,6-diynes: DNA cleavage, pH-dependent cytosine-specific interactions, and cancer cell cytotoxicity.
Topics: Alkynes; Antineoplastic Agents; Aza Compounds; Benzimidazoles; Benzothiazoles; Cytosine; DNA Adducts; DNA, Superhelical; Growth Inhibitors; Heterocyclic Compounds, 2-Ring; Hot Temperature; Humans; Hydrogen-Ion Concentration; Hydrolysis; Piperidines; Thiazoles; Tumor Cells, Cultured; U937 Cells | 2002 |
Antipsychotic profile of 5-[2-[4-(6-fluoro-1H-indole-3-yl)piperidin-1-yl]ethyl]-4-(4-fluorophenyl)thiazole-2-carboxylic acid amide (NRA0562) in rats.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Behavior, Animal; Clozapine; Dose-Response Relationship, Drug; Haloperidol; Male; Piperidines; Rats; Rats, Wistar; Risperidone; Thiazoles | 2002 |
In vitro and in vivo pharmacological profile of 5-[2-[4-(6-fluoro-1H-indole-3-yl)piperidin-1-yl]ethyl]-4-(4-fluorophenyl)thiazole-2-carboxylic acid amide (NRA0562), a novel and putative atypical antipsychotic.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Catalepsy; Central Nervous System Stimulants; Clozapine; Humans; Male; Methamphetamine; Motor Activity; Piperidines; Rats; Receptor, Serotonin, 5-HT2A; Receptors, Adrenergic, alpha-1; Receptors, Dopamine; Receptors, Drug; Receptors, Serotonin; Risperidone; Stereotyped Behavior; Thiazoles | 2002 |
Effect of novel modulators of protein kinase C activity upon chemotherapy-induced differentiation and apoptosis in myeloid leukemic cells.
Topics: Antineoplastic Agents; Apoptosis; CD11c Antigen; CD4 Antigens; Cell Cycle; Cell Differentiation; Diacylglycerol Kinase; Enzyme Activators; Enzyme Inhibitors; Farnesol; Flow Cytometry; Genes, fos; Genes, jun; Humans; Immunoblotting; Isoenzymes; Leukemia, Myeloid; Naphthalenes; Oncogene Protein p21(ras); Piperidines; Protein Kinase C; Pyrimidinones; Quinazolines; Quinazolinones; Sulfonamides; Thiazoles; Triazoles; Tumor Cells, Cultured | 2002 |
[Glinides and glitazones in diabetes treatment. Are they really effective?].
Topics: Carbamates; Cyclohexanes; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Insulin; Nateglinide; Phenylalanine; Pioglitazone; Piperidines; Rosiglitazone; Thiazoles; Thiazolidinediones; Treatment Outcome | 2002 |
Effect of clopidogrel administration to healthy volunteers on platelet phosphorylation events triggered by ADP.
Topics: Adenosine Diphosphate; Adolescent; Adult; Benzylamines; Blood Platelets; Clopidogrel; Electrophoresis, Polyacrylamide Gel; Humans; Male; Membrane Proteins; Phosphorylation; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Serine; Signal Transduction; Thiazoles; Thionucleotides; Threonine; Ticlopidine; Tyrosine | 2003 |
alpha2C-Adrenoceptor blockade by clozapine and other antipsychotic drugs.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Brimonidine Tartrate; Chlorpromazine; CHO Cells; Clozapine; Cricetinae; Cyclic AMP; Dibenzothiazepines; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Gene Expression; Haloperidol; Humans; Isoxazoles; Norepinephrine; Olanzapine; Piperazines; Piperidines; Pirenzepine; Quetiapine Fumarate; Quinolones; Quinoxalines; Receptors, Adrenergic, alpha-2; Receptors, Dopamine D2; Risperidone; Thiazoles; Transfection; Yohimbine | 2003 |
Inhibition of microsurgical thrombosis by the platelet glycoprotein IIb/IIIa antagonist SR121566A.
Topics: Anastomosis, Surgical; Animals; Arteries; Benzylamines; Bleeding Time; Ear, External; Male; Microscopy, Electron, Scanning; Microsurgery; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Rabbits; Surgical Flaps; Thiazoles; Thrombosis; Ultrasonography; Vascular Patency | 2003 |
Economic model of first-line drug strategies to achieve recommended glycaemic control in newly diagnosed type 2 diabetes mellitus.
Topics: Carbamates; Cohort Studies; Decision Trees; Diabetes Mellitus, Type 2; Direct Service Costs; Drug Costs; Drug Therapy, Combination; Glipizide; Glyburide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Managed Care Programs; Markov Chains; Metformin; Models, Economic; Piperidines; Rosiglitazone; Thiazoles; Thiazolidinediones; United States | 2003 |
Effects of NRA0045, a novel potent antagonist at dopamine D4, 5-HT2A, and alpha1 adrenaline receptors, and NRA0160, a selective D4 receptor antagonist, on phencyclidine-induced behavior and glutamate release in rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Chromatography, High Pressure Liquid; Clozapine; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Glutamic Acid; Haloperidol; Male; Microdialysis; Motor Activity; Phencyclidine; Piperidines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D4; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Stereotyped Behavior; Thiazoles; Time Factors | 2003 |
Lubeluzole and conditioned learning after cerebral ischemia.
Topics: Animals; Brain Ischemia; Conditioning, Psychological; Learning; Male; Piperidines; Rabbits; Thiazoles | 2003 |
Diverse regulation of atrial natriuretic peptide secretion by serotonin receptor subtypes.
Topics: Adenylyl Cyclase Inhibitors; Alkaloids; Aminobenzoates; Animals; Atrial Natriuretic Factor; Benzophenanthridines; Benzothiazoles; Calcium; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Depression, Chemical; Dose-Response Relationship, Drug; Heart; Heart Atria; Imines; Indoles; Isoquinolines; Ketanserin; Male; Myocytes, Cardiac; Neomycin; para-Aminobenzoates; Perfusion; Phenanthridines; Piperazines; Piperidines; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Staurosporine; Sulfonamides; Thiazoles; Type C Phospholipases | 2003 |
In vivo modulation of 5-hydroxytryptamine release in mouse prefrontal cortex by local 5-HT(2A) receptors: effect of antipsychotic drugs.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminopyridines; Anesthetics, Local; Animals; Antipsychotic Agents; Benzopyrans; Blotting, Western; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Fluorobenzenes; Immunohistochemistry; In Situ Hybridization; Indoles; Indophenol; Male; Mice; Mice, Inbred C57BL; Microdialysis; Piperidines; Prazosin; Prefrontal Cortex; Quinoxalines; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; RNA, Messenger; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Tetrodotoxin; Thiazoles; Time Factors | 2003 |
[Malysol and phenamizole, two new compounds for therapy of barbiturate poisoning].
Topics: Barbiturates; Piperidines; Poisoning; Thiazoles | 1955 |
[Daptazol and megimide in the treatment of acute barbiturate poisoning].
Topics: Barbiturates; Bemegride; Piperidines; Thiazoles | 1957 |
[Dapatazol & megimide in dicodid, barbiturate & largactil poisoning].
Topics: Barbiturates; Bemegride; Chlorpromazine; Codeine; Hydrocodone; Piperidines; Psychotropic Drugs; Thiazoles | 1956 |
[Progress in the treatment of barbiturate poisoning].
Topics: Barbiturates; Morphine; Piperidines; Thiazoles | 1958 |
[Production of 2-(beta-phenylethylamino)-piperidine and 2 -(beta-phenylethylamino)-thiazole].
Topics: Phenethylamines; Piperidines; Thiazoles | 1962 |
[LOCALIZATION OF THE SITE OF ACTION OF THE DIURETIC ETOZOLIN IN THE MEPHRON OF THE DOG AND REPORT OF A MATHEMATICAL EVALUATION METHOD OF STOP-FLOW EXPERIMENTS].
Topics: Diuretics; Dogs; Kidney; Pharmacology; Physiological Phenomena; Piperidines; Research; Thiazoles | 1964 |
A new treatment of barbiturate intoxication.
Topics: Barbiturates; Central Nervous System Stimulants; Piperidines; Poisoning; Thiazoles | 1955 |
[A new treatment of barbituric coma].
Topics: Ascomycota; Barbiturates; Coma; Piperidines; Poisoning; Thiazoles | 1955 |
R 56865 exerts cardioprotective properties independent of the intracellular Na(+)-overload in the guinea pig heart.
Topics: Animals; Benzothiazoles; Cardiotonic Agents; Energy Metabolism; Guinea Pigs; Hydrogen-Ion Concentration; In Vitro Techniques; Intracellular Space; Magnetic Resonance Spectroscopy; Myocardial Contraction; Myocardium; Myocytes, Cardiac; Piperidines; Sodium; Thiazoles; Time Factors | 2003 |
Flavopiridol potently induces small cell lung cancer apoptosis during S phase in a manner that involves early mitochondrial dysfunction.
Topics: Aphidicolin; Apoptosis; Blotting, Western; Carcinoma, Small Cell; Caspase 3; Caspases; Cell Division; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Humans; In Situ Nick-End Labeling; Lung Neoplasms; Membrane Potentials; Mitochondria; Piperidines; Poly(ADP-ribose) Polymerases; S Phase; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured; Tumor Stem Cell Assay | 2003 |
Study of the interaction of lubeluzole with cardiac sodium channels.
Topics: Animals; Dose-Response Relationship, Drug; Guinea Pigs; Male; Membrane Potentials; Myocardium; Piperidines; Sodium Channels; Thiazoles | 2003 |
Synthesis and evaluation of in vitro antimycobacterial activity of some 5-(5-nitro-2-thienyl)-2-(piperazinyl, piperidinyl and morpholinyl)-1,3,4-thiadiazole derivatives.
Topics: Antitubercular Agents; Indicators and Reagents; Microbial Sensitivity Tests; Morpholines; Mycobacterium tuberculosis; Piperazines; Piperidines; Thiazoles; Triazoles | 2003 |
Inhibition of cyclooxygenase-2 potentiates retrograde endocannabinoid effects in hippocampus.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Synergism; Endocannabinoids; Enzyme Inhibitors; Glycerides; Hippocampus; In Vitro Techniques; Isoenzymes; Male; Meloxicam; Membrane Potentials; Neural Inhibition; Patch-Clamp Techniques; Piperidines; Polyunsaturated Alkamides; Prostaglandin-Endoperoxide Synthases; Pyramidal Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides; Thiazines; Thiazoles | 2004 |
Total synthesis of thiostrepton, part 1: construction of the dehydropiperidine/thiazoline-containing macrocycle.
Topics: Macrocyclic Compounds; Molecular Conformation; Piperidines; Thiazoles; Thiostrepton | 2004 |
Preparation and physicochemical characterization of biodegradable nerve guides containing the nerve growth agent sabeluzole.
Topics: Absorbable Implants; Animals; Biocompatible Materials; Body Fluids; Diffusion; Drug Implants; Drug Stability; Equipment Failure Analysis; Humans; Lactic Acid; Materials Testing; Nerve Growth Factors; Nerve Regeneration; Peripheral Nerve Injuries; Peripheral Nerves; Piperidines; Polyesters; Polymers; Prosthesis Design; Temperature; Thiazoles | 2005 |
Characterization of functional effects of Z-338, a novel gastroprokinetic agent, on the muscarinic M1, M2, and M3 receptors expressed in Xenopus oocytes.
Topics: Acetylcholine; Animals; Benzamides; Dose-Response Relationship, Drug; Female; Gastrointestinal Agents; Gene Expression; Humans; Membrane Potentials; Muscarinic Antagonists; Oocytes; Piperidines; Pirenzepine; Potassium; Rats; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Reproducibility of Results; Thiazoles; Xenopus | 2004 |
E2F4 deficiency promotes drug-induced apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Cycle Proteins; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; E2F4 Transcription Factor; Fibroblasts; Flavonoids; Humans; Lung Neoplasms; Mice; Mice, Knockout; Oxazoles; Piperidines; Protein Kinase Inhibitors; Purines; RNA, Small Interfering; Roscovitine; Thiazoles; Transcription Factors; Tumor Cells, Cultured | 2004 |
Induction of apoptosis by flavopiridol in human neuroblastoma cells is enhanced under hypoxia and associated with N-myc proto-oncogene down-regulation.
Topics: Apoptosis; Bromodeoxyuridine; Caspases; Cell Hypoxia; Cell Survival; Cyclin-Dependent Kinases; Cytochromes c; DNA; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Flavonoids; G1 Phase; G2 Phase; Genes, myc; Growth Inhibitors; Humans; Hypoxia; In Situ Nick-End Labeling; Neuroblastoma; Piperidines; Proto-Oncogene Mas; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 2004 |
Bioisosteric replacements of the pyrazole moiety of rimonabant: synthesis, biological properties, and molecular modeling investigations of thiazoles, triazoles, and imidazoles as potent and selective CB1 cannabinoid receptor antagonists.
Topics: Administration, Oral; Animals; CHO Cells; Cricetinae; Cricetulus; Cyclohexanols; Hypotension; Hypothermia; Imidazoles; Mice; Models, Molecular; Molecular Conformation; Piperidines; Pyrazoles; Radioligand Assay; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Triazoles | 2005 |
Protective effects of Delta(9)-tetrahydrocannabinol against N-methyl-d-aspartate-induced AF5 cell death.
Topics: alpha-Tocopherol; Animals; Benzimidazoles; Benzoxazines; Blotting, Northern; Blotting, Western; Calcium Channel Blockers; Calcium Channels; Capsaicin; Cell Count; Cell Death; Cell Lineage; Dizocilpine Maleate; DNA, Single-Stranded; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Excitatory Amino Acid Agonists; Immunohistochemistry; In Situ Nick-End Labeling; Morpholines; N-Methylaspartate; Naphthalenes; Neurons; Neuroprotective Agents; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Ruthenium; Tetrazolium Salts; Thiazoles; TRPC Cation Channels | 2005 |
Dipeptidyl peptidase IV inhibitors derived from beta-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole.
Topics: Dipeptidyl Peptidase 4; Isoxazoles; Oxazoles; Piperidines; Protease Inhibitors; Pyrazoles; Thiazoles | 2005 |
Clozapine, ziprasidone and aripiprazole but not haloperidol protect against kainic acid-induced lesion of the striatum in mice, in vivo: role of 5-HT1A receptor activation.
Topics: Aminopyridines; Animals; Antipsychotic Agents; Aripiprazole; Clozapine; Corpus Striatum; Disease Models, Animal; Excitatory Amino Acid Agonists; Haloperidol; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Piperazines; Piperidines; Pyridines; Quinolones; Receptor, Serotonin, 5-HT1A; Schizophrenia; Serotonin 5-HT1 Receptor Agonists; Serotonin Antagonists; Thiazoles | 2005 |
Protective effect of donepezil against Abeta(1-40) neurotoxicity in rat septal neurons.
Topics: Acetylcholine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Cells, Cultured; Cholinergic Fibers; Cholinesterase Inhibitors; Donepezil; Down-Regulation; Fluorescent Dyes; Immunohistochemistry; Indans; L-Lactate Dehydrogenase; Membrane Transport Proteins; Molecular Structure; Neurons; Neuroprotective Agents; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Septal Nuclei; Thiazoles; Vesicular Acetylcholine Transport Proteins | 2005 |
Synthesis and some pharmacological properties of 3-(piperidin-4-yl)-4-substituted-D2-1,2,4-triazoline-5-thione derivatives.
Topics: 5-Hydroxytryptophan; Analgesics; Animals; Anti-Anxiety Agents; Anticonvulsants; Body Temperature; Central Nervous System Agents; Indicators and Reagents; Male; Mice; Pain Measurement; Piperidines; Psychomotor Performance; Sleep; Thiazoles | 2004 |
Inhibition of cyclooxygenase-2 elicits a CB1-mediated decrease of excitatory transmission in rat CA1 hippocampus.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Electrophysiology; Excitatory Postsynaptic Potentials; GABA Antagonists; Hippocampus; In Vitro Techniques; Male; Meloxicam; Membrane Potentials; Patch-Clamp Techniques; Piperidines; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, GABA-A; Rimonabant; Synaptic Transmission; Thiazines; Thiazoles | 2005 |
Combined effects of mechanical and ischemic injury to cortical cells: secondary ischemia increases damage and decreases effects of neuroprotective agents.
Topics: Animals; Brain Ischemia; Cell Count; Cell Survival; Cells, Cultured; Cerebral Cortex; Enzyme Inhibitors; Immunohistochemistry; Indazoles; Mice; Mitogen-Activated Protein Kinase 1; Neurons; Neuroprotective Agents; Nitric Oxide Synthase Type I; Physical Stimulation; Piperidines; Stress, Mechanical; Superoxide Dismutase; Thiazoles | 2005 |
Antinociceptive, brain-penetrating derivatives related to improgan, a non-opioid analgesic.
Topics: Algorithms; Analgesics; Animals; Behavior, Animal; Benzothiazoles; Brain; Cimetidine; Dose-Response Relationship, Drug; Histamine H2 Antagonists; Injections, Intraventricular; Male; Mice; Molecular Structure; Pain; Pain Measurement; Phenoxypropanolamines; Piperidines; Quinazolines; Quinazolinones; Rats; Rats, Sprague-Dawley; Thiazoles; Time Factors; Triazoles | 2005 |
Pharmacological characterisation of sodium channels in sinoatrial node pacemaking in the rat heart.
Topics: Animals; Benzothiazoles; Bradycardia; Heart Atria; Heart Rate; Lidocaine; Male; Piperidines; Rats; Rats, Sprague-Dawley; Sinoatrial Node; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin; Thiadiazoles; Thiazoles | 2006 |
American Heart Association--scientific sessions 2005. Potential new drugs for various indications. 13-16 November 2005, Dallas, TX, USA.
Topics: American Heart Association; Animals; Cardiotonic Agents; Heart Diseases; Humans; Piperidines; Potassium Channel Blockers; PPAR delta; Pyrazoles; Rimonabant; Thiazoles | 2006 |
Histamine increases sickle erythrocyte adherence to endothelium.
Topics: Analysis of Variance; Anemia, Sickle Cell; Cell Adhesion; Cells, Cultured; Endothelial Cells; Endothelium, Vascular; Erythrocytes; Famotidine; Histamine; Histamine Agonists; Histamine H1 Antagonists; Histamine H2 Antagonists; Humans; Imidazoles; Methylhistamines; P-Selectin; Piperidines; Pyrilamine; Stimulation, Chemical; Thiazoles; Thiourea; Venules | 2006 |
M1 receptors play a central role in modulating AD-like pathology in transgenic mice.
Topics: ADAM Proteins; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Antibodies, Monoclonal; Basigin; Behavior, Animal; Blotting, Western; Brain; Cell Count; Cytoskeletal Proteins; Dicyclomine; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Escape Reaction; Gene Expression; GTP-Binding Proteins; Humans; Immunohistochemistry; Memory Disorders; Mice; Mice, Transgenic; Muscarinic Antagonists; Nuclear Proteins; Piperidines; Protein Kinase C; Reaction Time; Receptor, Muscarinic M1; Spatial Behavior; Spiro Compounds; tau Proteins; Thiazoles; Time Factors | 2006 |
Facile, alternative route to lubeluzole, its enantiomer, and the racemate.
Topics: Cardiovascular Agents; Molecular Structure; Piperidines; Stereoisomerism; Thiazoles | 2006 |
Drug shows promise for treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Humans; Mice; Piperidines; Receptor, Muscarinic M1; Spiro Compounds; Thiazoles | 2006 |
Access to piperidine imino-C-glycosides via stereoselective thiazole-based aminohomologation of pyranoses.
Topics: Amines; Glycosides; Imino Sugars; Monosaccharides; Piperidines; Stereoisomerism; Thiazoles | 2006 |
Endocannabinoids modulate stress-induced suppression of hippocampal cell proliferation and activation of defensive behaviours.
Topics: Aggression; Animals; Arachidonic Acids; Behavior, Animal; Bromodeoxyuridine; Cannabinoid Receptor Modulators; Cell Count; Cell Proliferation; Endocannabinoids; Enzyme Inhibitors; Hippocampus; Immunohistochemistry; Male; Neural Inhibition; Odorants; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Stress, Psychological; Thiazoles | 2006 |
Antidepressant like effects of piperine in chronic mild stress treated mice and its possible mechanisms.
Topics: Alkaloids; Animals; Antidepressive Agents; Benzodioxoles; Brain-Derived Neurotrophic Factor; Cell Proliferation; Cell Survival; Cells, Cultured; Chronic Disease; Corticosterone; Depression; Hippocampus; Immunohistochemistry; L-Lactate Dehydrogenase; Male; Mice; Neurons; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Stem Cells; Stress, Psychological; Tetrazolium Salts; Thiazoles; Weight Gain | 2007 |
Synthesis and preliminary biological evaluation of 3-[(18)F]fluoro-5-(2-pyridinylethynyl)benzonitrile as a PET radiotracer for imaging metabotropic glutamate receptor subtype 5.
Topics: Animals; Benzimidazoles; Brain; Evaluation Studies as Topic; Excitatory Amino Acid Antagonists; Male; Nitriles; Piperidines; Positron-Emission Tomography; Pyridines; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Thiazoles; Tissue Distribution; Whole Body Imaging | 2007 |
Method development and validation for the simultaneous determination of meloxicam and pridinol mesylate using RP-HPLC and its application in drug formulations.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Cholinergic Antagonists; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; Meloxicam; Piperidines; Reproducibility of Results; Sensitivity and Specificity; Thiazines; Thiazoles | 2008 |
Comparative effects of olanzapine and ziprasidone on hypophagia induced by enhanced histamine neurotransmission in the rat.
Topics: Animals; Antipsychotic Agents; Appetite; Benzodiazepines; Brain; Dose-Response Relationship, Drug; Eating; Fat Emulsions, Intravenous; Histamine; Histamine H1 Antagonists; Histamine H3 Antagonists; Hypothalamus; Male; Neurons; Olanzapine; Piperazines; Piperidines; Rats; Synaptic Transmission; Taste; Thiazoles | 2008 |
Design and campaign synthesis of piperidine- and thiazole-based histone deacetylase inhibitors.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Crystallography, X-Ray; Dogs; Dose-Response Relationship, Drug; Drug Design; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Mice; Models, Molecular; Molecular Structure; Piperidines; Rats; Structure-Activity Relationship; Thiazoles; Xenograft Model Antitumor Assays | 2008 |
N-Acetylhexosaminidase inhibitory properties of C-1 homologated GlcNAc- and GalNAc-thiazolines.
Topics: beta-N-Acetylhexosaminidases; Binding Sites; Carbohydrate Sequence; Carbon; Enzyme Inhibitors; Galactose; Glucosamine; Kinetics; Models, Chemical; Molecular Sequence Data; Piperidines; Substrate Specificity; Thiazoles | 2008 |
Cannabinoid CB1 receptor antagonists in therapeutic and structural perspectives.
Topics: Animals; Anti-Obesity Agents; CHO Cells; Cricetinae; Cricetulus; Humans; Imidazoles; Isomerism; Models, Chemical; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Solubility; Structure-Activity Relationship; Thiazoles; Triazoles; Water | 2008 |
AKR-501 (YM477) in combination with thrombopoietin enhances human megakaryocytopoiesis.
Topics: Antigens, CD; Antigens, CD34; Blood Platelets; Cells, Cultured; Colony-Forming Units Assay; Flow Cytometry; Humans; Piperidines; Receptors, Thrombopoietin; Thiazoles; Thiophenes; Thrombocytopenia; Thrombopoiesis; Thrombopoietin | 2008 |
Effects of a hindered amine light stabilizer and a UV light absorber used in maxillofacial elastomers on human gingival epithelial cells and fibroblasts.
Topics: Cell Line; Cell Membrane; Cell Proliferation; Cell Survival; Colorimetry; Coloring Agents; Decanoic Acids; Epithelial Cells; Fibroblasts; Gingiva; Humans; L-Lactate Dehydrogenase; Materials Testing; Maxillofacial Prosthesis; Piperidines; Silicone Elastomers; Spectrophotometry; Tetrazolium Salts; Thiazoles; Time Factors; Triazoles | 2008 |
Platelet hyperprocoagulant activity in Type 2 diabetes mellitus: attenuation by glycoprotein IIb/IIIa inhibition.
Topics: Benzylamines; Blood Platelets; Case-Control Studies; Diabetes Mellitus, Type 2; Humans; Phosphatidylserines; Piperidines; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Receptors, Thrombin; Thiazoles; Thrombophilia | 2008 |
A CB(2) receptor agonist, A-836339, modulates wide dynamic range neuronal activity in neuropathic rats: contributions of spinal and peripheral CB(2) receptors.
Topics: Action Potentials; Animals; Camphanes; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Ganglia, Spinal; Male; Neurons; Peripheral Nervous System Diseases; Physical Stimulation; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Rimonabant; Spinal Cord; Thiazoles | 2009 |
Insulin action on polyunsaturated phosphatidic acid formation in rat brain: an "in vitro" model with synaptic endings from cerebral cortex and hippocampus.
Topics: Animals; Cerebral Cortex; Chromones; Cyclosporine; Diacylglycerol Kinase; Diglycerides; Genistein; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Insulin; Insulin Antagonists; Morpholines; Okadaic Acid; Phosphatidic Acids; Phosphoprotein Phosphatases; Piperidines; Pyrimidinones; Quinazolinones; Rats; Rats, Wistar; Sodium Fluoride; Synaptosomes; Thiazoles; Vanadates | 2009 |
Role of protein kinase C epsilon (PKCvarepsilon) in the reduction of ethanol reinforcement due to mGluR5 antagonism in the nucleus accumbens shell.
Topics: Animals; Central Nervous System Depressants; Ethanol; Excitatory Amino Acid Antagonists; Feeding Behavior; Male; Motor Activity; Nucleus Accumbens; Piperidines; Protein Kinase C-epsilon; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Reinforcement Schedule; Signal Transduction; Thiazoles | 2009 |
Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia.
Topics: Adult; Aged; Aged, 80 and over; Apoptosis; Caspases; Cyclin-Dependent Kinases; Female; Flavonoids; Humans; Immunoblotting; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Male; Membrane Potential, Mitochondrial; Middle Aged; Myeloid Cell Leukemia Sequence 1 Protein; Oxazoles; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Purines; RNA Polymerase II; RNA, Neoplasm; Roscovitine; Thiazoles; Transcription, Genetic; X-Linked Inhibitor of Apoptosis Protein | 2009 |
Dissociation of the effects of MTEP [3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]piperidine] on conditioned reinstatement and reinforcement: comparison between cocaine and a conventional reinforcer.
Topics: Animals; Behavior, Animal; Cocaine; Conditioning, Classical; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Extinction, Psychological; Locomotion; Male; Milk; Piperidines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Reinforcement Schedule; Reinforcement, Psychology; Self Administration; Thiazoles | 2009 |
Synthesis and herbicidal activities of novel 4-(4-(5-methyl-3-arylisoxazol-4-yl)thiazol-2-yl)piperidyl carboxamides and thiocarboxamides.
Topics: Binding, Competitive; Computer Simulation; Herbicides; Isoxazoles; Models, Molecular; Piperidines; Plant Proteins; Protease Inhibitors; Spinacia oleracea; Thiazoles | 2009 |
Pharmacokinetics of masitinib in cats.
Topics: Animals; Benzamides; Biological Availability; Cats; Dogs; Female; Injections, Intravenous; Male; Mast Cells; Piperidines; Proto-Oncogene Proteins c-kit; Pyridines; Rats; Thiazoles | 2009 |
Effect of non-dopaminergic drug treatment on Levodopa induced dyskinesias in MPTP monkeys: common implication of striatal neuropeptides.
Topics: Animals; Antiparkinson Agents; Benzoxazoles; Cocaine; Corpus Striatum; Disease Models, Animal; Docosahexaenoic Acids; Dopamine; Dopamine Uptake Inhibitors; Dynorphins; Dyskinesia, Drug-Induced; Enkephalins; Female; Iodine Isotopes; Levodopa; Macaca fascicularis; Naltrexone; Neuropeptides; Ovariectomy; Parkinsonian Disorders; Piperidines; Protein Precursors; RNA, Messenger; Sulfonamides; Tachykinins; Thiazoles; Time Factors | 2010 |
More about masitinib.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Benzamides; Clinical Trials, Phase II as Topic; Humans; Piperidines; Pyridines; Thiazoles | 2009 |
Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KIT.
Topics: Animals; Benzamides; Bone Marrow Cells; Drug Evaluation, Preclinical; Female; Humans; Inhibitory Concentration 50; Mice; Mice, Nude; Models, Molecular; Mutation; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-kit; Pyridines; Recombinant Proteins; Thiazoles | 2009 |
Churg and Strauss vasculitis in the course of masitinib treatment: a first report.
Topics: Asthma; Benzamides; Churg-Strauss Syndrome; Humans; Male; Middle Aged; Piperidines; Protein-Tyrosine Kinases; Pyridines; Thiazoles; Treatment Outcome | 2010 |
Masitinib for the treatment of canine atopic dermatitis: a pilot study.
Topics: Animals; Benzamides; Dermatitis, Atopic; Dog Diseases; Dogs; Drug-Related Side Effects and Adverse Reactions; Pilot Projects; Piperidines; Pruritus; Pyridines; Severity of Illness Index; Skin; Thiazoles; Treatment Outcome | 2010 |
Masitinib combined with standard gemcitabine chemotherapy: in vitro and in vivo studies in human pancreatic tumour cell lines and ectopic mouse model.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Disease Models, Animal; Gemcitabine; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Inhibitory Concentration 50; Male; Mice; Mice, SCID; Pancreatic Neoplasms; Piperidines; Pyridines; Thiazoles | 2010 |
Reduction of L-DOPA-induced dyskinesia by the selective metabotropic glutamate receptor 5 antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Behavior, Animal; Dyskinesia, Drug-Induced; Female; Levodopa; Macaca fascicularis; Male; Motor Activity; MPTP Poisoning; Parkinson Disease, Secondary; Piperidines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Thiazoles | 2010 |
Plaque deposition dependent decrease in 5-HT2A serotonin receptor in AbetaPPswe/PS1dE9 amyloid overexpressing mice.
Topics: Aging; Amphetamines; Amyloid beta-Protein Precursor; Aniline Compounds; Animals; Autoradiography; Citalopram; Data Interpretation, Statistical; Fluorobenzenes; Genes, fos; Head Movements; Humans; In Situ Hybridization; Indicators and Reagents; Male; Mice; Mice, Transgenic; Piperidines; Plaque, Amyloid; Receptor, Serotonin, 5-HT2A; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Serotonin Receptor Agonists; Thiazoles | 2010 |
Chemoproteomics-based kinome profiling and target deconvolution of clinical multi-kinase inhibitors in primary chronic lymphocytic leukemia cells.
Topics: Apoptosis; Flavonoids; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Oxazoles; Piperidines; Positive Transcriptional Elongation Factor B; Protein Kinase Inhibitors; Proteomics; Thiazoles | 2011 |
Evaluation of 12- and 24-month survival rates after treatment with masitinib in dogs with nonresectable mast cell tumors.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Benzamides; Dog Diseases; Dogs; Mast-Cell Sarcoma; Neoplasm Staging; Patient Selection; Piperidines; Predictive Value of Tests; Pyridines; Survival Rate; Survivors; Thiazoles; Time Factors | 2010 |
Metabotropic glutamate receptor 5/Homer interactions underlie stress effects on fear.
Topics: Analysis of Variance; Animals; Association Learning; Blotting, Western; Carrier Proteins; Cells, Cultured; Conditioning, Psychological; Excitatory Amino Acid Antagonists; Fear; Hippocampus; Homer Scaffolding Proteins; Immunohistochemistry; Male; Mice; Mice, Inbred BALB C; Neurons; Piperidines; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Restraint, Physical; Stress, Physiological; Stress, Psychological; Thiazoles | 2010 |
Ligand-induced internalization of the orexin OX(1) and cannabinoid CB(1) receptors assessed via N-terminal SNAP and CLIP-tagging.
Topics: Alkyl and Aryl Transferases; Benzoxazoles; Cell Line; Cell Membrane; Cloning, Molecular; Cyclohexanols; Extracellular Signal-Regulated MAP Kinases; Humans; Intracellular Signaling Peptides and Proteins; Ligands; Naphthyridines; Neuropeptides; Orexin Receptors; Orexins; Phenylurea Compounds; Phosphorylation; Piperidines; Plasmids; Pyrazoles; Pyrrolidines; Receptor, Cannabinoid, CB1; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Rimonabant; Thiazoles; Urea | 2011 |
Clinical trial on the efficacy of masitinib in canine IBD.
Topics: Animals; Anti-Inflammatory Agents; Benzamides; Clinical Trials as Topic; Dog Diseases; Dogs; Inflammatory Bowel Diseases; Piperidines; Pyridines; Thiazoles; Treatment Outcome | 2010 |
Streptococcus mutans diacylglycerol kinase homologue: a potential target for anti-caries chemotherapy.
Topics: Cariostatic Agents; Dental Caries; Diacylglycerol Kinase; Enzyme Inhibitors; Genes, Bacterial; Humans; Hydrogen-Ion Concentration; Mutation; Piperidines; Pyrimidinones; Quinazolinones; Streptococcus mutans; Thiazoles | 2011 |
Masitinib as a chemosensitizer of canine tumor cell lines: a proof of concept study.
Topics: Animals; Antineoplastic Agents; Benzamides; Cell Line, Tumor; Deoxycytidine; Dog Diseases; Dogs; Doxorubicin; Drug Synergism; Gemcitabine; Inhibitory Concentration 50; Piperidines; Protein Kinase Inhibitors; Pyridines; Sarcoma; Thiazoles; Vinblastine | 2012 |
Update on newer antipsychotic drugs.
Topics: Adult; Aged; Antipsychotic Agents; Bipolar Disorder; Child; Clinical Trials as Topic; Dibenzocycloheptenes; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Isoindoles; Isoxazoles; Lurasidone Hydrochloride; Male; Piperidines; Pregnancy; Schizophrenia; Thiazoles; Treatment Outcome | 2011 |
The cannabinoid receptor inverse agonist AM251 regulates the expression of the EGF receptor and its ligands via destabilization of oestrogen-related receptor α protein.
Topics: Cell Line, Tumor; Epidermal Growth Factor; ErbB Receptors; ERRalpha Estrogen-Related Receptor; Genistein; HCT116 Cells; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Ligands; Nitriles; Orphan Nuclear Receptors; Piperidines; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Estrogen; RNA, Messenger; Thiazoles; Up-Regulation | 2011 |
mGluR5 and NMDA receptors drive the experience- and activity-dependent NMDA receptor NR2B to NR2A subunit switch.
Topics: Adaptation, Physiological; Animals; Animals, Newborn; Electric Stimulation; Enzyme Inhibitors; Estrenes; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Hippocampus; In Vitro Techniques; Male; Mice; Mice, Knockout; Models, Biological; N-Methylaspartate; Piperidines; Pyramidal Cells; Pyridines; Pyrrolidinones; Quinoxalines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synapses; Thiazoles; Time Factors; Visual Cortex | 2011 |
[KIT and KIT: from biology to clinical use].
Topics: Antineoplastic Agents; Benzamides; Benzenesulfonates; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Indoles; Niacinamide; Phenylurea Compounds; Piperazines; Piperidines; Prognosis; Protein Kinase Inhibitors; Proto-Oncogene Mas; Proto-Oncogene Proteins c-kit; Pyridines; Pyrimidines; Pyrroles; Sorafenib; Sunitinib; Thiazoles | 2012 |
Cerebral serotonin 4 receptors and amyloid-β in early Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Brain; Brain Chemistry; Cognition; Female; Humans; Image Processing, Computer-Assisted; Ligands; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Piperidines; Positron-Emission Tomography; Radiopharmaceuticals; Receptors, Serotonin, 5-HT4; Thiazoles | 2011 |
(-)-2-oxa-4-aminobicylco[3.1.0]hexane-4,6-dicarboxylic acid (LY379268) and 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]piperidine (MTEP) similarly attenuate stress-induced reinstatement of cocaine seeking.
Topics: Amino Acids; Analysis of Variance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Central Nervous System Stimulants; Cocaine-Related Disorders; Conditioning, Operant; Excitatory Amino Acid Antagonists; Extinction, Psychological; Male; Piperidines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Stress, Psychological; Thiazoles | 2012 |
Combination of docetaxel and vandetanib in docetaxel-sensitive or resistant PC3 cell line.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Coloring Agents; Docetaxel; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; ErbB Receptors; Gene Expression Regulation, Neoplastic; Humans; Male; Piperidines; Prostatic Neoplasms, Castration-Resistant; Quinazolines; Taxoids; Tetrazolium Salts; Thiazoles; Vascular Endothelial Growth Factor Receptor-2 | 2013 |
Discovery, synthesis, and biological evaluation of novel SMN protein modulators.
Topics: Alternative Splicing; Caco-2 Cells; Cell Membrane Permeability; Drug Design; Exons; Fibroblasts; Genes, Reporter; HEK293 Cells; Humans; Luciferases, Firefly; Male; Microsomes, Liver; Muscular Atrophy, Spinal; Piperidines; Promoter Regions, Genetic; Structure-Activity Relationship; Survival of Motor Neuron 1 Protein; Survival of Motor Neuron 2 Protein; Thiadiazoles; Thiazoles; Transcription, Genetic | 2011 |
Biological perspectives: update on newer antipsychotic drugs: are they evidence based?
Topics: Antipsychotic Agents; Cyclooxygenase 2 Inhibitors; Dibenzocycloheptenes; Evidence-Based Medicine; Heterocyclic Compounds, 4 or More Rings; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Isoindoles; Isoxazoles; Lactones; Lurasidone Hydrochloride; Piperidines; Psychotic Disorders; Pyridines; Serotonin Receptor Agonists; Sulfones; Thiazoles | 2011 |
Stevens-Johnson Syndrome induced by masitinib.
Topics: Adenocarcinoma; Benzamides; Colonic Neoplasms; Drug Eruptions; Humans; Male; Middle Aged; Piperidines; Protein Kinase Inhibitors; Pyridines; Stevens-Johnson Syndrome; Thiazoles | 2012 |
Selective 5-HT(1A)-R-agonist repinotan prevents remifentanil-induced ventilatory depression and prolongs antinociception.
Topics: Analgesics, Opioid; Anesthetics, Intravenous; Animals; Benzopyrans; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Hemodynamics; Hypnotics and Sedatives; Male; Pain Measurement; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Remifentanil; Respiratory Insufficiency; Respiratory Mechanics; Serotonin Receptor Agonists; Thiazoles | 2012 |
The mGlu5 receptor antagonist MTEP attenuates opiate self-administration and cue-induced opiate-seeking behaviour in mice.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Conditioning, Operant; Cues; Dose-Response Relationship, Drug; Injections, Intravenous; Male; Mice; Morphine; Motor Activity; Narcotics; Opioid-Related Disorders; Piperidines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Reinforcement, Psychology; Self Administration; Substance Abuse, Intravenous; Thiazoles | 2012 |
Impact of mGluR5 during amphetamine-induced hyperactivity and conditioned hyperactivity in differentially reared rats.
Topics: Amphetamine; Animals; Behavior, Animal; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Hyperkinesis; Male; Motor Activity; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Social Isolation; Thiazoles | 2012 |
AChE inhibitor: a regio- and stereo-selective 1,3-dipolar cycloaddition for the synthesis of novel substituted 5,6-dimethoxy spiro[5.3']-oxindole-spiro-[6.3″]-2,3-dihydro-1H-inden-1″-one-7-(substituted aryl)-tetrahydro-1H-pyrrolo[1,2-c][1,3]thiazole.
Topics: Acetylcholinesterase; Alzheimer Disease; Azo Compounds; Chemistry, Pharmaceutical; Cholinesterase Inhibitors; Donepezil; Drug Design; Humans; Indans; Indoles; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Molecular; Molecular Conformation; Piperidines; Spiro Compounds; Structure-Activity Relationship; Temperature; Thiazoles; Thiosemicarbazones; Triazoles | 2012 |
Masitinib demonstrates anti-proliferative and pro-apoptotic activity in primary and metastatic feline injection-site sarcoma cells.
Topics: Animals; Antineoplastic Agents; Benzamides; Cat Diseases; Cats; Cell Line, Tumor; Dose-Response Relationship, Drug; Flow Cytometry; Gene Expression Regulation, Neoplastic; Piperidines; Platelet-Derived Growth Factor; Pyridines; Receptors, Platelet-Derived Growth Factor; Sarcoma; Soft Tissue Neoplasms; Thiazoles; Vaccines, Inactivated | 2012 |
Mast cell leukemia: identification of a new c-Kit mutation, dup(501-502), and response to masitinib, a c-Kit tyrosine kinase inhibitor.
Topics: Aged; Animals; Antineoplastic Agents; Base Sequence; Benzamides; Chlorocebus aethiops; COS Cells; Female; Humans; Immunophenotyping; Leukemia, Mast-Cell; Mast Cells; Mutation; Neoplastic Cells, Circulating; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyridines; Thiazoles; Tryptases | 2012 |
Investigation of the antidyskinetic site of action of metabotropic and ionotropic glutamate receptor antagonists. Intracerebral infusions in 6-hydroxydopamine-lesioned rats with levodopa-induced dyskinesia.
Topics: Animals; Anti-Dyskinesia Agents; Disease Models, Animal; Dyskinesia, Drug-Induced; Excitatory Amino Acid Antagonists; Infusions, Intraventricular; Levodopa; Male; Oxidopamine; Phenols; Piperidines; Putamen; Quinoxalines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Substantia Nigra; Subthalamic Nucleus; Thiazoles | 2012 |
Negative inotropic effect of a CB2 agonist A-955840 in isolated rabbit ventricular myocytes is independent of CB1 and CB2 receptors.
Topics: Animals; Benzamides; Calcium Channels, L-Type; Dogs; Heart Ventricles; Inhibitory Concentration 50; Male; Myocardial Contraction; Myocytes, Cardiac; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rabbits; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Sarcomeres; Thiazoles | 2011 |
The tyrosine kinase inhibitor masitinib blunts airway inflammation and improves associated lung mechanics in a feline model of chronic allergic asthma.
Topics: Allergens; Animals; Anti-Asthmatic Agents; Asthma; Benzamides; Bronchoalveolar Lavage Fluid; Cats; Chronic Disease; Cynodon; Eosinophils; Immunoglobulin E; Inflammation; Lung; Male; Methacholine Chloride; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyridines; Thiazoles | 2012 |
Design, synthesis, and antiviral activity of entry inhibitors that target the CD4-binding site of HIV-1.
Topics: Amides; Anti-HIV Agents; CD4 Antigens; Cell Line, Tumor; Crystallography, X-Ray; Databases, Factual; Drug Design; HIV Envelope Protein gp120; HIV-1; Humans; Models, Molecular; Oxalates; Piperidines; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Virus Internalization | 2012 |
Virosecurinine induces apoptosis by affecting Bcl-2 and Bax expression in human colon cancer SW480 cells.
Topics: Actins; Alkaloids; Antineoplastic Agents, Phytogenic; Apoptosis; Azepines; bcl-2-Associated X Protein; Cell Cycle; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Coloring Agents; Euphorbiaceae; Gene Expression; Humans; Lactones; Piperidines; Proto-Oncogene Proteins c-bcl-2; Real-Time Polymerase Chain Reaction; Tetrazolium Salts; Thiazoles | 2012 |
In vitro effects of the tyrosine kinase inhibitor, masitinib mesylate, on canine hemangiosarcoma cell lines.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzamides; Caspase 3; Caspase 7; Cell Line, Tumor; Cell Survival; Dogs; Dose-Response Relationship, Drug; Hemangiosarcoma; In Situ Nick-End Labeling; In Vitro Techniques; Neoplasms, Vascular Tissue; Piperidines; Protein-Tyrosine Kinases; Pyridines; Skin Neoplasms; Thiazoles; Vascular Endothelial Growth Factor A | 2012 |
Prevention of the phencyclidine-induced impairment in novel object recognition in female rats by co-administration of lurasidone or tandospirone, a 5-HT(1A) partial agonist.
Topics: Animals; Cognition Disorders; Disease Models, Animal; Dopamine D2 Receptor Antagonists; Female; Haloperidol; Isoindoles; Lurasidone Hydrochloride; Phencyclidine; Piperazines; Piperidines; Pyridines; Pyrimidines; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Serotonin 5-HT2 Receptor Agonists; Thiazoles; Urea | 2012 |
Transcriptome and proteome analysis of tyrosine kinase inhibitor treated canine mast cell tumour cells identifies potentially kit signaling-dependent genes.
Topics: Animals; Benzamides; Cell Death; Cell Line, Tumor; Cell Proliferation; Dogs; Gene Expression Regulation, Neoplastic; Mastocytoma; Piperidines; Proto-Oncogene Proteins c-kit; Pyridines; RNA, Messenger; Signal Transduction; Thiazoles; Transcriptome; Up-Regulation | 2012 |
Functional and binding kinetic studies make a distinction between OX1 and OX2 orexin receptor antagonists.
Topics: Acetamides; Animals; Benzofurans; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Dioxanes; Humans; Isoquinolines; Kinetics; Orexin Receptors; Phenylurea Compounds; Piperidines; Protein Binding; Pyrimidines; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Thiazoles | 2012 |
Lab reports and cat scans: can veterinary oncology guide our way to new treatments for human cancers?
Topics: Animals; Antineoplastic Agents; Benzamides; Breast Neoplasms; Cats; Disease Models, Animal; Dogs; Female; Humans; Imatinib Mesylate; Indoles; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mast-Cell Sarcoma; Neoplasms; Piperazines; Piperidines; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Pyrroles; Thiazoles; Transcriptome | 2012 |
Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator.
Topics: Animals; Dose-Response Relationship, Drug; Humans; KCNQ1 Potassium Channel; Molecular Structure; Piperidines; Rats; Structure-Activity Relationship; Substrate Specificity; Thiazoles; Tosyl Compounds | 2012 |
PARP-1 inhibitors DPQ and PJ-34 negatively modulate proinflammatory commitment of human glioblastoma cells.
Topics: Anti-Inflammatory Agents; Biomarkers; Brain Neoplasms; Carnosine; Cell Line, Tumor; Cell Survival; Coloring Agents; Down-Regulation; Fluorescent Antibody Technique; Glioblastoma; Humans; Isoquinolines; L-Lactate Dehydrogenase; Microscopy, Confocal; Nitrites; Phenanthrenes; Piperidines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Tetrazolium Salts; Thiazoles; Trehalose | 2013 |
Interactions of CB1 and mGlu5 receptor antagonists in food intake, anxiety and memory models in rats.
Topics: Animals; Anxiety; Disease Models, Animal; Fear; Feeding Behavior; Male; Memory; Piperidines; Pyrazoles; Pyridines; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Rimonabant; Thiazoles | 2012 |
Lead optimization of thiazolo[5,4-c]piperidines: 3-cyclobutoxy linker as a key spacer for H(3)R inverse agonists.
Topics: Animals; Benzamides; Caco-2 Cells; Histamine Agonists; Humans; Male; Piperidines; Rats; Rats, Wistar; Receptors, Histamine H3; Structure-Activity Relationship; Thiazoles; Trans-Activators; Transcriptional Regulator ERG | 2012 |
Molecular dissection of lubeluzole use-dependent block of voltage-gated sodium channels discloses new therapeutic potentials.
Topics: Anesthetics, Local; Binding Sites; Cell Line; HEK293 Cells; Humans; Membrane Potentials; Membrane Proteins; Mutation; NAV1.4 Voltage-Gated Sodium Channel; Neuroprotective Agents; Piperidines; Protein Binding; Protein Interaction Domains and Motifs; Protein Isoforms; Riluzole; Sodium Channel Blockers; Thiazoles | 2013 |
In-vitro growth inhibition of chemotherapy and molecular targeted agents in hepatocellular carcinoma.
Topics: Alanine; alpha-Fetoproteins; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Carcinoma, Hepatocellular; Cetuximab; Dasatinib; Doxorubicin; Drug Screening Assays, Antitumor; Epothilones; Gefitinib; Humans; Indoles; Inhibitory Concentration 50; Liver Neoplasms; Niacinamide; Phenylurea Compounds; Piperidines; Pyridones; Pyrimidines; Pyrroles; Quinazolines; Sorafenib; Sunitinib; Thiazoles; Triazines | 2013 |
Masitinib reverses doxorubicin resistance in canine lymphoid cells by inhibiting the function of P-glycoprotein.
Topics: Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzamides; Cell Line, Tumor; Dogs; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Neoplasm; Fluoresceins; Gene Expression Regulation; Piperidines; Protein Kinase Inhibitors; Pyridines; Rhodamine 123; Succinimides; Thiazoles | 2013 |
Protecting group-free concise synthesis of (RS)/(S)-lubeluzole.
Topics: Hydrogen Bonding; Molecular Structure; Piperidines; Solvents; Stereoisomerism; Thiazoles; Water | 2013 |
Apoptotic effects of the tyrosine kinase inhibitor, masitinib mesylate, on canine osteosarcoma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzamides; Bone Neoplasms; Cell Line, Tumor; Cell Survival; Dogs; Dose-Response Relationship, Drug; Osteosarcoma; Piperidines; Protein Kinase Inhibitors; Pyridines; Thiazoles; Vascular Endothelial Growth Factor A | 2013 |
4-Bromo-2-(piperidin-1-yl)thiazol-5-yl-phenyl methanone (12b) inhibits Na+/K(+)-ATPase and Ras oncogene activity in cancer cells.
Topics: Animals; Brain; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Kidney; Kinetics; MCF-7 Cells; Microscopy, Phase-Contrast; Microscopy, Video; Models, Chemical; Molecular Structure; Piperidines; Protein Subunits; Proto-Oncogene Proteins p21(ras); Sodium-Potassium-Exchanging ATPase; Thiazoles | 2013 |
Diacylglycerol kinase α is a critical signaling node and novel therapeutic target in glioblastoma and other cancers.
Topics: Apoptosis; Brain Neoplasms; Cell Line, Tumor; Diacylglycerol Kinase; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Molecular Targeted Therapy; Piperidines; Pyrimidinones; Quinazolinones; RNA, Small Interfering; Thiazoles | 2013 |
Simultaneous analysis of anticancer agents bortezomib, imatinib, nilotinib, dasatinib, erlotinib, lapatinib, sorafenib, sunitinib and vandetanib in human plasma using LC/MS/MS.
Topics: Antineoplastic Agents; Benzamides; Boronic Acids; Bortezomib; Chromatography, Liquid; Dasatinib; Erlotinib Hydrochloride; Humans; Imatinib Mesylate; Indoles; Lapatinib; Niacinamide; Phenylurea Compounds; Piperazines; Piperidines; Pyrazines; Pyrimidines; Pyrroles; Quinazolines; Reproducibility of Results; Sorafenib; Sunitinib; Tandem Mass Spectrometry; Thiazoles | 2013 |
Tyrosine kinase inhibitors induce down-regulation of c-Kit by targeting the ATP pocket.
Topics: Adenosine Triphosphate; Benzamides; Binding Sites; Cell Line; Down-Regulation; Erythroblasts; Humans; Imatinib Mesylate; Ligands; Lysosomes; Piperazines; Piperidines; Protein Kinase Inhibitors; Protein Transport; Protein-Tyrosine Kinases; Proteolysis; Proto-Oncogene Proteins c-kit; Pyridines; Pyrimidines; Thiazoles | 2013 |
Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels.
Topics: Action Potentials; Animals; CHO Cells; Cricetinae; Cricetulus; HEK293 Cells; Humans; Ion Transport; KCNQ1 Potassium Channel; Muscle Proteins; Myocytes, Cardiac; Piperidines; Potassium; Potassium Channels, Voltage-Gated; Protein Multimerization; Thiazoles; Tosyl Compounds | 2013 |
Influence of different cell storage/culture conditions on spontaneous proliferation and level of tyrosine kinase receptor inhibition in two feline injection-site sarcoma cell lines.
Topics: Animals; Apoptosis; Benzamides; Cats; Cell Culture Techniques; Cell Line, Tumor; Cell Proliferation; Cell Survival; Piperidines; Preservation, Biological; Protein Kinase Inhibitors; Pyridines; Sarcoma; Thiazoles | 2013 |
An atom economic synthesis and AChE inhibitory activity of novel dispiro 7-aryltetrahydro-1H-pyrrolo[1,2-c][1,3]thiazole and 4-aryloctahydroindolizine N-methylpiperidin-4-one hybrid heterocycles.
Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Electrophorus; Models, Molecular; Molecular Structure; Piperidines; Pyrroles; Structure-Activity Relationship; Thiazoles | 2013 |
New drugs 2013, part 2.
Topics: Acetanilides; Adrenergic beta-Agonists; Anti-Asthmatic Agents; Anti-Retroviral Agents; Bronchodilator Agents; Citrates; Crotonates; Drug Approval; Humans; Hydroxybutyrates; Immunosuppressive Agents; Laxatives; Nitriles; Organometallic Compounds; Peptides; Picolines; Piperidines; Pyrimidines; Pyrroles; Quinolones; Receptors, Guanylate Cyclase-Coupled; Thiazoles; Toluidines; Tropanes | 2013 |
Masitinib mesylate for metastatic and non-resectable canine cutaneous mast cell tumours.
Topics: Animals; Benzamides; Disease-Free Survival; Dog Diseases; Dogs; Female; Kaplan-Meier Estimate; Male; Mastocytosis, Cutaneous; Neoplasm Staging; Piperidines; Protein Kinase Inhibitors; Pyridines; Schools, Veterinary; Skin Neoplasms; Tennessee; Thiazoles | 2015 |
A convenient synthesis of lubeluzole and its enantiomer: evaluation as chemosensitizing agents on human ovarian adenocarcinoma and lung carcinoma cells.
Topics: Adenocarcinoma; Antineoplastic Agents; Cell Line, Tumor; Doxorubicin; Drug Synergism; Female; Humans; Lung Neoplasms; Ovarian Neoplasms; Paclitaxel; Piperidines; Stereoisomerism; Thiazoles | 2013 |
Evaluations of the selectivities of the diacylglycerol kinase inhibitors R59022 and R59949 among diacylglycerol kinase isozymes using a new non-radioactive assay method.
Topics: Animals; Chlorocebus aethiops; COS Cells; Diacylglycerol Kinase; Enzyme Inhibitors; High-Throughput Screening Assays; Isoenzymes; Piperidines; Pyrimidinones; Quinazolinones; Thiazoles | 2013 |
The orthosteric GABAA receptor ligand Thio-4-PIOL displays distinctly different functional properties at synaptic and extrasynaptic receptors.
Topics: Animals; Anxiety; Behavior, Animal; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Partial Agonism; GABA-A Receptor Agonists; HEK293 Cells; Humans; Ligands; Male; Membrane Potentials; Memory; Motor Activity; Nociception; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, GABA; Synapses; Thiazoles; Time Factors; Transfection; Xenopus laevis | 2013 |
The antidepressant-like action of mGlu5 receptor antagonist, MTEP, in the tail suspension test in mice is serotonin dependent.
Topics: Animals; Antidepressive Agents; Citalopram; Diet; Excitatory Amino Acid Antagonists; Fenclonine; Fluoxetine; Hindlimb Suspension; Male; Mice; Mice, Inbred C57BL; Motor Activity; Piperidines; Receptors, Kainic Acid; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Thiazoles; Tryptophan | 2014 |
A novel mGluR5 antagonist, MFZ 10-7, inhibits cocaine-taking and cocaine-seeking behavior in rats.
Topics: Allosteric Regulation; Analysis of Variance; Animals; Binding, Competitive; Cocaine; Cues; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Antagonists; HEK293 Cells; Humans; Imidazoles; In Vitro Techniques; Infusions, Intravenous; Inhibitory Concentration 50; Male; Motor Activity; Nitriles; Piperidines; Pyridines; Random Allocation; Rats; Receptor, Metabotropic Glutamate 5; Reinforcement Schedule; Reward; Secondary Prevention; Self Administration; Sucrose; Thiazoles | 2014 |
Modulation of the foreign body response to implanted sensor models through device-based delivery of the tyrosine kinase inhibitor, masitinib.
Topics: Animals; Benzamides; Biocompatible Materials; Biosensing Techniques; Foreign-Body Reaction; Lactic Acid; Male; Mice; Mice, Inbred C57BL; Piperidines; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Prostheses and Implants; Protein Kinase Inhibitors; Pyridines; Thiazoles | 2013 |
Thiazole-aminopiperidine hybrid analogues: design and synthesis of novel Mycobacterium tuberculosis GyrB inhibitors.
Topics: Animals; Antitubercular Agents; Cell Line; Cell Survival; DNA Gyrase; Dose-Response Relationship, Drug; Drug Design; Mice; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Mycobacterium tuberculosis; Piperidines; Structure-Activity Relationship; Thiazoles; Topoisomerase II Inhibitors | 2013 |
Comparative effect of lurasidone and blonanserin on cortical glutamate, dopamine, and acetylcholine efflux: role of relative serotonin (5-HT)2A and DA D2 antagonism and 5-HT1A partial agonism.
Topics: Acetylcholine; Animals; Antipsychotic Agents; Brain; Cerebral Cortex; Dopamine; Glutamic Acid; Hippocampus; Isoindoles; Lurasidone Hydrochloride; Male; Microdialysis; Neurotransmitter Agents; Nucleus Accumbens; Piperazines; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D2; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Synaptic Transmission; Thiazoles | 2014 |
Masitinib antagonizes ATP-binding cassette subfamily C member 10-mediated paclitaxel resistance: a preclinical study.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; HEK293 Cells; Humans; Mice; Multidrug Resistance-Associated Proteins; Paclitaxel; Piperidines; Pyridines; Thiazoles | 2014 |
Glutamate prevents intestinal atrophy via luminal nutrient sensing in a mouse model of total parenteral nutrition.
Topics: Animal Nutrition Sciences; Animals; Atrophy; Cell Proliferation; Disease Models, Animal; Down-Regulation; Epithelial Cells; Epithelium; Food; Glucagon-Like Peptide 2; Glutamic Acid; Intestinal Mucosa; Jejunum; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Parenteral Nutrition, Total; Permeability; Piperidines; Receptor, Metabotropic Glutamate 5; Receptors, G-Protein-Coupled; Signal Transduction; Thiazoles | 2014 |
Masitinib mesylate does not enhance sensitivity to radiation in three feline injection-site sarcoma cell lines under normal growth conditions.
Topics: Animals; Benzamides; Cat Diseases; Cats; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Piperidines; Protein Kinase Inhibitors; Pyridines; Radiation-Sensitizing Agents; Sarcoma; Thiazoles | 2014 |
Preclinical evaluation of marketed sodium channel blockers in a rat model of myotonia discloses promising antimyotonic drugs.
Topics: Animals; Carbamazepine; Disease Models, Animal; Flecainide; HEK293 Cells; Humans; Mexiletine; Muscle, Skeletal; Myotonia Congenita; Orphenadrine; Piperidines; Propafenone; Rats; Rats, Wistar; Riluzole; Sodium Channel Blockers; Thiazoles | 2014 |
Masitinib antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzamides; Cell Line, Tumor; Drug Resistance, Multiple; Drug Synergism; HEK293 Cells; Humans; Mitoxantrone; Models, Molecular; Molecular Docking Simulation; Neoplasm Proteins; Piperidines; Protein Kinase Inhibitors; Pyridines; Thiazoles | 2014 |
Piroxicam inhibits Masitinib-induced cyclooxygenase 2 expression in oral squamous cell carcinoma cells in vitro.
Topics: Animals; Benzamides; Carcinoma, Squamous Cell; Cats; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dogs; Gene Expression Regulation, Enzymologic; Humans; Mouth Neoplasms; Piperidines; Piroxicam; Protein Kinase Inhibitors; Pyridines; Thiazoles | 2014 |
Competitive antagonism of insect GABA receptors by 4-substituted 5-(4-piperidyl)-3-isothiazolols.
Topics: Animals; Binding, Competitive; Dose-Response Relationship, Drug; GABA Antagonists; Houseflies; Insecticides; Models, Molecular; Molecular Structure; Piperidines; Receptors, GABA; Structure-Activity Relationship; Thiazoles | 2014 |
Functional characterization of BTK(C481S) mutation that confers ibrutinib resistance: exploration of alternative kinase inhibitors.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Antineoplastic Agents; B-Lymphocytes; Cell Line, Tumor; Cyclohexylamines; Dasatinib; Drug Resistance, Neoplasm; Female; Gene Expression; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Middle Aged; Mutation; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Pyrroles; RNA, Small Interfering; Signal Transduction; Structure-Activity Relationship; Thiazoles | 2015 |
A retrospective review of treatment and response of high-risk mast cell tumours in dogs.
Topics: Animals; Antineoplastic Agents; Benzamides; Chemotherapy, Adjuvant; Dog Diseases; Dogs; Mastocytoma; Neoplasm Grading; Piperidines; Protein Kinase Inhibitors; Pyridines; Retrospective Studies; Risk Factors; Survival Analysis; Thiazoles; Treatment Outcome | 2016 |
Relationship between in vivo receptor occupancy and efficacy of metabotropic glutamate receptor subtype 5 allosteric modulators with different in vitro binding profiles.
Topics: Allosteric Regulation; Amphetamine; Animals; Benzamides; Calcium; Cerebellum; Corpus Striatum; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Locomotion; Male; Maze Learning; Niacinamide; Piperidines; Positron-Emission Tomography; Radioligand Assay; Rats; Receptor, Metabotropic Glutamate 5; Structure-Activity Relationship; Thiazoles | 2015 |
Neuroprotective effect of masitinib in rats with postischemic stroke.
Topics: Animals; Behavior, Animal; Benzamides; Brain; Brain Ischemia; Drug Synergism; Drug Therapy, Combination; Hypnotics and Sedatives; Male; Neuroprotective Agents; Piperidines; Pyridines; Rats, Wistar; Stroke; Thiazoles; Tissue Plasminogen Activator | 2015 |
Biochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug target.
Topics: Amino Acid Sequence; Antitubercular Agents; Aspartate-tRNA Ligase; Cloning, Molecular; Crystallography, X-Ray; Dimerization; Drug Resistance, Multiple, Bacterial; Humans; Microbial Sensitivity Tests; Molecular Sequence Data; Mycobacterium bovis; Mycobacterium smegmatis; Mycobacterium tuberculosis; Piperidines; Polymorphism, Single Nucleotide; Protein Binding; Recombinant Fusion Proteins; Sequence Alignment; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Thiazoles; Tuberculosis, Pulmonary | 2014 |
Monoamine Oxidase Inhibition and Molecular Modeling Studies of Piperidyl-thienyl and 2-Pyrazoline Derivatives of Chalcones.
Topics: Animals; Binding Sites; Chalcones; Enzyme Activation; Humans; Inhibitory Concentration 50; Models, Molecular; Molecular Structure; Monoamine Oxidase Inhibitors; Piperidines; Rabbits; Thiazoles | 2015 |
Augmenting anti-cancer natural products with a small molecule adjuvant.
Topics: Adjuvants, Pharmaceutic; Animals; Antineoplastic Agents; Biological Products; Brain Neoplasms; Cell Line, Tumor; Glycolipids; Humans; Marine Toxins; MCF-7 Cells; Mice; Neuroblastoma; Peptides, Cyclic; Piperidines; Rats; Seawater; Thiazoles | 2014 |
The targeting of human and mouse B lymphocytes by dasatinib.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Animals; Antigens, CD19; Apoptosis; B-Lymphocytes; Bone Marrow Cells; Dasatinib; Flow Cytometry; Humans; Male; Mice, Inbred C57BL; Phospholipase C gamma; Piperidines; Precursor Cells, B-Lymphoid; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Receptors, Antigen, B-Cell; Receptors, Antigen, T-Cell; Signal Transduction; Spleen; Thiazoles; Time Factors | 2015 |
Understanding responder neurobiology in schizophrenia using a quantitative systems pharmacology model: application to iloperidone.
Topics: Antipsychotic Agents; Computer Simulation; Genotype; Humans; Isoxazoles; Models, Biological; Molecular Targeted Therapy; Neurobiology; Pharmacogenetics; Piperazines; Piperidines; Schizophrenia; Thiazoles | 2015 |
Characterization of a novel KCNQ1 mutation for type 1 long QT syndrome and assessment of the therapeutic potential of a novel IKs activator using patient-specific induced pluripotent stem cell-derived cardiomyocytes.
Topics: Action Potentials; Adult; Cell Differentiation; Cell Line; Cellular Reprogramming Techniques; Electrocardiography; Female; Humans; Induced Pluripotent Stem Cells; KCNQ1 Potassium Channel; Male; Middle Aged; Myocytes, Cardiac; Patch-Clamp Techniques; Piperidines; Potassium Channels, Voltage-Gated; RNA, Messenger; Romano-Ward Syndrome; Sequence Deletion; Thiazoles; Tosyl Compounds; Young Adult | 2015 |
Interactions of cyclin-dependent kinase inhibitors AT-7519, flavopiridol and SNS-032 with ABCB1, ABCG2 and ABCC1 transporters and their potential to overcome multidrug resistance in vitro.
Topics: Animals; ATP-Binding Cassette Transporters; Cell Proliferation; Dogs; Drug Interactions; Drug Resistance, Multiple; Flavonoids; Humans; Madin Darby Canine Kidney Cells; Oxazoles; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Thiazoles | 2015 |
Dissociable effects of mGluR5 allosteric modulation on distinct forms of impulsivity in rats: interaction with NMDA receptor antagonism.
Topics: Allosteric Regulation; Animals; Choice Behavior; Delay Discounting; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Imidazoles; Impulsive Behavior; Male; Motor Activity; Oxadiazoles; Piperidines; Pyridines; Rats; Reaction Time; Receptor, Metabotropic Glutamate 5; Receptors, N-Methyl-D-Aspartate; Thiazoles | 2015 |
Synthesis, computational and spectroscopic analysis on (E)-(4-(2-(benzo[d]thiazol-2-yl)hydrazono)-3-methyl-2,6-diphenylpiperidine-1-yl)(phenyl)methanone using DFT approach.
Topics: Entropy; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Piperidines; Quantum Theory; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Static Electricity; Thermodynamics; Thiazoles; Vibration | 2015 |
Structure-Based Design of a Small Molecule CD4-Antagonist with Broad Spectrum Anti-HIV-1 Activity.
Topics: Anti-HIV Agents; CD4 Antigens; Cell Fusion; Cell Line; HIV Envelope Protein gp120; HIV Reverse Transcriptase; HIV-1; Humans; Hydrogen Bonding; Models, Molecular; Molecular Conformation; Oxalates; Piperidines; Protein Conformation; Pyrroles; Receptors, CCR5; Receptors, CXCR4; Reverse Transcriptase Inhibitors; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Virus Internalization | 2015 |
Endocannabinoid Modulation of Predator Stress-Induced Long-Term Anxiety in Rats.
Topics: Amygdala; Animals; Anxiety; Arachidonic Acids; Benzodioxoles; Endocannabinoids; Enzyme Inhibitors; Glycerides; Male; Monoacylglycerol Lipases; Piperidines; Rats; Rats, Sprague-Dawley; Stress, Psychological; Thiazoles | 2016 |
Local release of masitinib alters in vivo implantable continuous glucose sensor performance.
Topics: Animals; Benzamides; Biosensing Techniques; Blood Glucose; Blood Glucose Self-Monitoring; Drug Implants; Equipment Design; Equipment Failure Analysis; Male; Mice; Mice, Inbred C57BL; Piperidines; Prostheses and Implants; Pyridines; Reproducibility of Results; Sensitivity and Specificity; Thiazoles | 2016 |
Autoimmune-like hepatitis during masitinib therapy in an amyotrophic lateral sclerosis patient.
Topics: Adult; Amyotrophic Lateral Sclerosis; Azathioprine; Benzamides; Biopsy; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Female; Hepatitis, Autoimmune; Humans; Immunosuppressive Agents; Piperidines; Prednisone; Protein Kinase Inhibitors; Pyridines; Randomized Controlled Trials as Topic; Severity of Illness Index; Thiazoles; Time Factors; Treatment Outcome | 2015 |
Differential interactions of 5-(4-piperidyl)-3-isoxazolol analogues with insect γ-aminobutyric acid receptors leading to functional selectivity.
Topics: Animals; GABA Antagonists; Insect Proteins; Insecta; Insecticides; Ligands; Molecular Docking Simulation; Piperidines; Receptors, GABA; Structure-Activity Relationship; Thiazoles | 2015 |
Rapid and clinically significant response to masitinib in the treatment of mucosal primary esophageal melanoma with somatic KIT exon 11 mutation involving brain metastases: A case report.
Topics: Benzamides; Brain Neoplasms; Esophageal Neoplasms; Exons; Fatal Outcome; Humans; Male; Melanoma; Middle Aged; Mutation; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyridines; Thiazoles | 2015 |
The cKit Inhibitor, Masitinib, Prevents Diabetes-Induced Retinal Vascular Leakage.
Topics: Animals; Benzamides; Blood-Retinal Barrier; Blotting, Western; Capillary Permeability; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Endothelium, Vascular; Gene Expression Regulation; Humans; Immunohistochemistry; Intravitreal Injections; Male; Mice; Mice, Inbred C57BL; Piperidines; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; Retinal Diseases; Retinal Vessels; Reverse Transcriptase Polymerase Chain Reaction; RNA; Signal Transduction; Stem Cell Factor; Thiazoles; Vascular Resistance | 2016 |
The chemosensitizing agent lubeluzole binds calmodulin and inhibits Ca(2+)/calmodulin-dependent kinase II.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calmodulin; Cattle; Humans; Molecular Docking Simulation; Piperidines; Protein Conformation; Protein Kinase Inhibitors; Thiazoles | 2016 |
Piperidinyl thiazole isoxazolines: A new series of highly potent, slowly reversible FAAH inhibitors with analgesic properties.
Topics: Amidohydrolases; Analgesics; Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Isoxazoles; Kinetics; Male; Mice; Mice, Inbred ICR; Molecular Docking Simulation; Molecular Structure; Pain; Pain Measurement; Piperidines; Structure-Activity Relationship; Thiazoles | 2016 |
Identification of Candidate Cyclin-dependent kinase 1 (Cdk1) Substrates in Mitosis by Quantitative Phosphoproteomics.
Topics: CDC2 Protein Kinase; Chromatography, Liquid; Cyclin-Dependent Kinases; Flavonoids; Gene Expression Regulation; HeLa Cells; Humans; Mitosis; Phosphoproteins; Piperidines; Protein Interaction Maps; Proteomics; Quinolines; Signal Transduction; Small Molecule Libraries; Tandem Mass Spectrometry; Thiazoles | 2016 |
Clinical response of masitinib mesylate in the treatment of canine macroscopic mast cell tumours.
Topics: Animals; Antineoplastic Agents; Benzamides; Dog Diseases; Dogs; Female; Male; Mast Cells; Neoplasms, Connective Tissue; Piperidines; Pyridines; Retrospective Studies; Survival Rate; Thiazoles | 2016 |
Sympathetic β-adrenergic mechanism in pudendal inhibition of nociceptive and non-nociceptive reflex bladder activity.
Topics: Adrenergic beta-Antagonists; Animals; Cats; Denervation; Electric Stimulation; Female; Hypogastric Plexus; Male; Nociception; Piperidines; Propranolol; Pudendal Nerve; Rats; Receptors, Adrenergic, beta; Reflex; Thiazoles; Urinary Bladder | 2016 |
Benzylpiperidine-Linked Diarylthiazoles as Potential Anti-Alzheimer's Agents: Synthesis and Biological Evaluation.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Butyrylcholinesterase; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Humans; Male; Mice; Molecular Structure; Piperidines; Rats; Rats, Wistar; Reactive Oxygen Species; Structure-Activity Relationship; Thiazoles; Tumor Cells, Cultured | 2016 |
Antiproliferative effects of masitinib and imatinib against canine oral fibrosarcoma in vitro.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Cell Line, Tumor; Cell Proliferation; Dog Diseases; Dogs; Doxorubicin; Fibrosarcoma; Imatinib Mesylate; Mouth Neoplasms; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyridines; Receptor, Platelet-Derived Growth Factor alpha; Receptor, Platelet-Derived Growth Factor beta; Thiazoles; Vascular Endothelial Growth Factor Receptor-2 | 2016 |
Post-paralysis tyrosine kinase inhibition with masitinib abrogates neuroinflammation and slows disease progression in inherited amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Benzamides; Cell Death; Disease Models, Animal; Disease Progression; Encephalitis; Humans; Male; Motor Neurons; Mutation; Neuroglia; Paralysis; Piperidines; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Transgenic; Spinal Cord; Superoxide Dismutase; Thiazoles | 2016 |
Presumed masitinib-induced nephrotic syndrome and azotemia in a dog.
Topics: Animals; Antineoplastic Agents; Azotemia; Benzamides; Dog Diseases; Dogs; Female; Mastocytoma; Nephrotic Syndrome; Piperidines; Protein-Tyrosine Kinases; Pyridines; Thiazoles | 2016 |
IL-4 downregulates expression of the target receptor CD30 in neoplastic canine mast cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzamides; Brentuximab Vedotin; Cell Line, Tumor; Cytokines; Dog Diseases; Dogs; Down-Regulation; Drug Synergism; Female; Immunoconjugates; Interleukin-4; Ki-1 Antigen; Male; Mastocytosis; Piperidines; Pyridines; Staurosporine; Thiazoles | 2017 |
High-frequency stimulation-induced synaptic potentiation in dorsal and ventral CA1 hippocampal synapses: the involvement of NMDA receptors, mGluR5, and (L-type) voltage-gated calcium channels.
Topics: Animals; CA1 Region, Hippocampal; Calcium Channel Blockers; Calcium Channels, L-Type; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Long-Term Potentiation; Male; Nimodipine; Piperazines; Piperidines; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, N-Methyl-D-Aspartate; Thiazoles | 2016 |
Discovery and Optimization of N-Substituted 2-(4-pyridinyl)thiazole carboxamides against Tumor Growth through Regulating Angiogenesis Signaling Pathways.
Topics: Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chick Embryo; Colony-Forming Units Assay; Drug Design; Drug Discovery; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice, Nude; Neoplasms; Neovascularization, Pathologic; Phosphorylation; Piperidines; Quinazolines; Rats, Sprague-Dawley; Signal Transduction; Stress Fibers; Thiazoles; Wound Healing | 2016 |
The Effects of Pharmacological Compounds on Beat Rate Variations in Human Long QT-Syndrome Cardiomyocytes.
Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Bisoprolol; Cells, Cultured; Dose-Response Relationship, Drug; Female; Fractals; Heart Conduction System; Heart Rate; Humans; Induced Pluripotent Stem Cells; Long QT Syndrome; Myocytes, Cardiac; Piperidines; Thiazoles; Time Factors; Tosyl Compounds | 2016 |
Therapies: Progressive steps.
Topics: Animals; Antibodies, Monoclonal, Humanized; Antigens, CD20; Azetidines; B-Lymphocytes; Benzamides; Benzyl Compounds; Blood-Brain Barrier; Clinical Trials as Topic; Disease Progression; Dogs; Drug Approval; Fingolimod Hydrochloride; Hope; Humans; Male; Mice; Multiple Sclerosis, Chronic Progressive; Neuroprotective Agents; Piperidines; Precision Medicine; Pyridines; Rituximab; Thiazoles; Ubiquinone; United States; United States Food and Drug Administration | 2016 |
Do K
Topics: Animals; Aorta; Dose-Response Relationship, Drug; KCNQ1 Potassium Channel; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Structure-Activity Relationship; Thiazoles; Tosyl Compounds | 2017 |
Estrogens synthesized and acting within a spinal oligomer suppress spinal endomorphin 2 antinociception: ebb and flow over the rat reproductive cycle.
Topics: Analgesics, Opioid; Animals; Aromatase; Benzimidazoles; Enzyme Inhibitors; Estrogen Receptor Modulators; Estrogens; Estrous Cycle; Excitatory Amino Acid Agents; Fadrozole; Female; Injections, Spinal; Oligopeptides; Piperidines; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, Opioid, mu; Spinal Cord; Thiazoles | 2017 |
Subacute cutaneous lupus erythematosus induced by masitinib.
Topics: Aged; Antineoplastic Agents; Benzamides; Drug Eruptions; Female; Humans; Lupus Erythematosus, Cutaneous; Piperidines; Protein Kinase Inhibitors; Pyridines; Thiazoles | 2017 |
Drug therapy: On the treatment trail for ALS.
Topics: Amyotrophic Lateral Sclerosis; Antipyrine; Benzamides; C9orf72 Protein; Clinical Trials as Topic; Disease Progression; Drug Therapy, Combination; Edaravone; Genetic Therapy; Humans; Imidazoles; Mesenchymal Stem Cells; Motor Neurons; Neuroglia; Off-Label Use; Oligoribonucleotides, Antisense; Piperidines; Precision Medicine; Pyrazines; Pyridines; Riluzole; RNAi Therapeutics; Stem Cell Transplantation; Superoxide Dismutase; Thiazoles; United States; United States Food and Drug Administration | 2017 |
Evidence for mast cells contributing to neuromuscular pathology in an inherited model of ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Axons; Benzamides; Disease Models, Animal; Male; Mast Cells; Muscle, Skeletal; Neuromuscular Diseases; Neuromuscular Junction; Piperidines; Pyridines; Rats; Thiazoles | 2017 |
Survival of pancreatic cancer cells lacking KRAS function.
Topics: Animals; Antineoplastic Agents; Benzimidazoles; Carcinoma, Pancreatic Ductal; DNA Copy Number Variations; Humans; Immunoblotting; Indazoles; Mice; Morpholines; Pancreatic Neoplasms; Phenylurea Compounds; Piperidines; Proto-Oncogene Mas; Proto-Oncogene Proteins p21(ras); Purines; Pyrimidines; Pyrimidinones; Quinazolinones; Sulfonamides; Thiazoles | 2017 |
Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology.
Topics: A549 Cells; Antineoplastic Agents; Benzamides; Cell Line, Tumor; Crystallography, X-Ray; Deoxycytidine; Deoxycytidine Kinase; Drug Design; Drug Resistance, Neoplasm; Enzyme Activation; Gemcitabine; Humans; Imatinib Mesylate; Models, Biological; Models, Molecular; Phosphorylation; Piperidines; Polypharmacology; Protein Kinase Inhibitors; Proteomics; Pyridines; Thiazoles | 2017 |
Allosteric Inhibitors of SHP2 with Therapeutic Potential for Cancer Treatment.
Topics: Adaptor Proteins, Signal Transducing; Administration, Oral; Allosteric Regulation; Animals; Antineoplastic Agents; Binding Sites; Cell Proliferation; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Female; Humans; Inhibitory Concentration 50; MAP Kinase Signaling System; Mice, Inbred BALB C; Mice, Nude; Mutation; Naphthalenes; Phosphoproteins; Piperidines; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Structure-Activity Relationship; Thiazoles; Transcription Factors; Xenograft Model Antitumor Assays; YAP-Signaling Proteins | 2017 |
Chlorocarbonylsulfenyl Chloride Cyclizations Towards Piperidin-3-yl-oxathiazol-2-ones as Potential Covalent Inhibitors of Threonine Proteases.
Topics: Cyclization; Piperidines; Protease Inhibitors; Thiazoles; Threonine | 2017 |
Motor neuron disease in 2017: Progress towards therapy in motor neuron disease.
Topics: Amyotrophic Lateral Sclerosis; Benzamides; Edaravone; Humans; Muscular Atrophy, Spinal; Neuroprotective Agents; Oligonucleotides; Oligoribonucleotides, Antisense; Piperidines; Pyridines; Thiazoles; Thionucleotides | 2018 |
Selective Blockade of the Metabotropic Glutamate Receptor mGluR5 Protects Mouse Livers in In Vitro and Ex Vivo Models of Ischemia Reperfusion Injury.
Topics: Adenosine Triphosphate; Animals; Cell Hypoxia; Disease Models, Animal; Hepatocytes; Imidazoles; Liver; Mice; Mitochondria, Liver; Piperidines; Pyridines; Rats; Receptor, Metabotropic Glutamate 5; Reperfusion Injury; Thiazoles; Tumor Necrosis Factor-alpha | 2018 |
p110α Inhibition Overcomes Stromal Cell-Mediated Ibrutinib Resistance in Mantle Cell Lymphoma.
Topics: Adenine; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line; Cell Line, Tumor; Class I Phosphatidylinositol 3-Kinases; Drug Resistance, Neoplasm; Humans; Interleukin Receptor Common gamma Subunit; Lymphoma, Mantle-Cell; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; Piperidines; Pyrazoles; Pyrimidines; Stromal Cells; Thiazoles; Tumor Burden; Xenograft Model Antitumor Assays | 2018 |
Decrease of cocaine, but not heroin, self-administration and relapse by the tyrosine kinase inhibitor masitinib in male Sprague Dawley rats.
Topics: Administration, Oral; Analgesics, Opioid; Animals; Behavior, Addictive; Benzamides; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Heroin; Male; Motivation; Piperidines; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; Recurrence; Reinforcement, Psychology; Self Administration; Thiazoles | 2018 |
Molecular Insights into hERG Potassium Channel Blockade by Lubeluzole.
Topics: Animals; CHO Cells; Cricetulus; Ether-A-Go-Go Potassium Channels; HEK293 Cells; Humans; Molecular Docking Simulation; Neuroprotective Agents; Patch-Clamp Techniques; Piperidines; Point Mutation; Protein Binding; Protein Conformation, alpha-Helical; Thiazoles | 2018 |
Masitinib in treatment of pancreatic cancer.
Topics: Benzamides; Humans; Pancreatic Neoplasms; Piperidines; Protein Kinase Inhibitors; Pyridines; Survival Rate; Thiazoles | 2018 |
Anticancer and radiosensitizing effects of the cyclin-dependent kinase inhibitors, AT7519 and SNS‑032, on cervical cancer.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinases; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Lung Neoplasms; Mice; Oxazoles; Piperidines; Pyrazoles; Radiation-Sensitizing Agents; Thiazoles; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays | 2018 |
Cyclooxygenase inhibitors potentiate receptor tyrosine kinase therapies in bladder cancer cells in vitro.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Axitinib; Benzamides; Caspases; Cell Line, Tumor; Cell Survival; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Dogs; Dose-Response Relationship, Drug; Drug Synergism; Humans; Imidazoles; Indazoles; Indomethacin; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-kit; Pyridines; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Thiazoles; Urinary Bladder Neoplasms | 2018 |
In Vitro Screening of Six Protein Kinase Inhibitors for Time-Dependent Inhibition of CYP2C8 and CYP3A4: Possible Implications with regard to Drug-Drug Interactions.
Topics: Benzamides; Benzimidazoles; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C8 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Humans; Indoles; Inhibitory Concentration 50; Microsomes, Liver; Phthalazines; Piperidines; Pyridines; Pyridones; Pyrimidinones; Quinolones; Staurosporine; Thiazoles | 2018 |
Identification and characterization of prescription drugs that change levels of 7-dehydrocholesterol and desmosterol.
Topics: Benzamides; Cell Line, Tumor; Dehydrocholesterols; Desmosterol; Drug Evaluation, Preclinical; Gene Expression Regulation; High-Throughput Screening Assays; Humans; Imidazoles; Nerve Tissue Proteins; Oxidoreductases Acting on CH-CH Group Donors; Piperidines; Prescription Drugs; Pyridazines; Pyridines; Thiazoles; United States; United States Food and Drug Administration | 2018 |
Mast cells and neutrophils mediate peripheral motor pathway degeneration in ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Axons; Benzamides; Cell Degranulation; Disease Models, Animal; Humans; Male; Mast Cells; Motor Neurons; Muscle, Skeletal; Neuromuscular Junction; Neutrophil Infiltration; Neutrophils; Piperidines; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Transgenic; Superoxide Dismutase; Superoxide Dismutase-1; Thiazoles; Treatment Outcome | 2018 |
Identification of a novel DGKα inhibitor for XLP-1 therapy by virtual screening.
Topics: Cell Death; Computer Simulation; Diacylglycerol Kinase; Drug Evaluation, Preclinical; Humans; Lymphoproliferative Disorders; Piperidines; Protein Kinase Inhibitors; Pyrimidinones; Quinazolinones; Ritanserin; Thiazoles | 2019 |
Synaptic Depotentiation and mGluR5 Activity in the Nucleus Accumbens Drive Cocaine-Primed Reinstatement of Place Preference.
Topics: Animals; Cocaine; Conditioning, Operant; Electrophysiological Phenomena; Long-Term Synaptic Depression; Male; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Nucleus Accumbens; Optogenetics; Patch-Clamp Techniques; Piperidines; Receptors, AMPA; Receptors, Kainic Acid; Signal Transduction; Synaptic Potentials; Thiazoles | 2019 |
PBPK modeling coupled with biorelevant dissolution to forecast the oral performance of amorphous solid dispersion formulations.
Topics: Administration, Oral; Animals; Computer Simulation; Dogs; Drug Compounding; Excipients; Intestinal Absorption; Male; Models, Biological; Particle Size; Piperidines; Porosity; Pyrrolidines; Solubility; Tablets; Thiazoles | 2019 |
ML277 specifically enhances the fully activated open state of KCNQ1 by modulating VSD-pore coupling.
Topics: Animals; Cell Membrane; Cell Polarity; Humans; KCNQ1 Potassium Channel; Long QT Syndrome; Oocytes; Piperidines; Potassium; Potassium Channels, Voltage-Gated; Thiazoles; Tosyl Compounds; Xenopus | 2019 |
Bidirectional linkage between the B-cell receptor and NOTCH1 in chronic lymphocytic leukemia and in Richter's syndrome: therapeutic implications.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Amyloid Precursor Protein Secretases; Animals; Calcium; Diamines; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Mice; Mice, Inbred NOD; Mice, SCID; Middle Aged; Piperidines; Pyrazoles; Pyrimidines; Receptor, Notch1; Receptors, Antigen, B-Cell; Signal Transduction; Syndrome; Thiazoles | 2020 |
In pursuit of the normal progressor: the holy grail for ALS clinical trial design?
Topics: Amyotrophic Lateral Sclerosis; Benzamides; Clinical Trials as Topic; Humans; Piperidines; Pyridines; Riluzole; Thiazoles | 2020 |
Experimental analysis of the onset mechanism of TdP reported in an LQT3 patient during pharmacological treatment with serotonin-dopamine antagonists against insomnia and nocturnal delirium.
Topics: Action Potentials; Anesthetics, Inhalation; Animals; Calcium Channel Agonists; Cardiac Conduction System Disease; Delirium; Dogs; Dopamine Antagonists; Dose-Response Relationship, Drug; Electrocardiography; Female; Halothane; Heart Conduction System; Humans; Isoindoles; Long QT Syndrome; Middle Aged; Models, Animal; Piperazines; Piperidines; Potassium Channel Blockers; Serotonin Antagonists; Sleep Initiation and Maintenance Disorders; Thiazoles; Torsades de Pointes | 2020 |
Neuraminidase from Influenza A and B Viruses is Susceptible to the Compound 4-(4-Phenyl-1H-1,2,3-Triazol-1-yl)-2,2,6,6-Tetramethylpiperidine-1- Oxyl.
Topics: Antiviral Agents; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Influenza A virus; Influenza B virus; Microbial Sensitivity Tests; Molecular Docking Simulation; Molecular Structure; Neuraminidase; Piperidines; Structure-Activity Relationship; Thiazoles; Triazoles | 2020 |
Prospective clinical trial of masitinib mesylate treatment for advanced stage III and IV canine malignant melanoma.
Topics: Animals; Benzamides; Dog Diseases; Dogs; Melanoma; Piperidines; Prospective Studies; Pyridines; Skin Neoplasms; Thiazoles | 2020 |
Extensive vitiligo associated to response to c-kit inhibitor in metastatic mucosal melanoma.
Topics: Antineoplastic Agents; Benzamides; Female; Humans; Lymphatic Metastasis; Melanoma; Middle Aged; Piperidines; Prognosis; Proto-Oncogene Proteins c-kit; Pyridines; Thiazoles; Vitiligo; Vulvar Neoplasms | 2020 |
Small Molecule Inhibition of CPS1 Activity through an Allosteric Pocket.
Topics: Adenosine Triphosphate; Allosteric Regulation; Carbamoyl-Phosphate Synthase (Ammonia); Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Hydrolysis; Models, Molecular; Molecular Structure; Piperidines; Small Molecule Libraries; Thiazoles | 2020 |
The secondary KIT mutation p.Ala510Val in a cutaneous mast cell tumour carrying the activating mutation p.Asn508Ile confers resistance to masitinib in dogs.
Topics: Animals; Antineoplastic Agents; Benzamides; Dog Diseases; Dogs; Drug Resistance, Neoplasm; Female; Gain of Function Mutation; HEK293 Cells; Humans; Mastocytosis, Cutaneous; Piperidines; Proto-Oncogene Proteins c-kit; Pyridines; Skin Neoplasms; Thiazoles; Vinblastine | 2020 |
The role of glutamate mGlu5 and adenosine A2a receptor interactions in regulating working memory performance and persistent cocaine seeking in rats.
Topics: Adenosine A2 Receptor Antagonists; Animals; Cocaine-Related Disorders; Conditioning, Operant; Drug-Seeking Behavior; Male; Memory, Short-Term; Motor Activity; Piperidines; Psychomotor Performance; Purines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptor, Metabotropic Glutamate 5; Recurrence; Self Administration; Thiazoles | 2020 |
Effects of Chronic Masitinib Treatment in APPswe/PSEN1dE9 Transgenic Mice Modeling Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzamides; Cognition; Disease Models, Animal; Male; Mice, Transgenic; Piperidines; Presenilin-1; Pyridines; Synapses; Thiazoles | 2020 |
Overview of current and emerging therapies for amytrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Antibodies, Monoclonal, Humanized; Benzamides; Edaravone; Humans; Mesenchymal Stem Cells; Oligonucleotides; Piperidines; Pyridines; Riluzole; Thiazoles | 2020 |
A highly potent PROTAC androgen receptor (AR) degrader ARD-61 effectively inhibits AR-positive breast cancer cell growth in vitro and tumor growth in vivo.
Topics: Androgen Receptor Antagonists; Animals; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Movement; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Humans; In Vitro Techniques; Mice; Mice, SCID; Piperidines; Proteolysis; Pyrrolidines; Receptors, Androgen; Thiazoles; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2020 |
Lubeluzole: from anti-ischemic drug to preclinical antidiarrheal studies.
Topics: Animals; Anti-Bacterial Agents; Antidiarrheals; Bacteria; Colon; Diarrhea; Dose-Response Relationship, Drug; Gram-Negative Bacterial Infections; Gram-Positive Bacterial Infections; Guinea Pigs; Ileum; Loperamide; Male; Microbial Sensitivity Tests; Muscle Contraction; Neuroprotective Agents; Piperidines; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Thiazoles | 2021 |
Avatrombopag Optimizes Response to Niraparib by Managing Thrombocytopenia Associated with Poly-ADP Ribose Polymerase (PARP) Inhibition in Ovarian Cancer and Breast Cancer: A Case Series.
Topics: Adenosine Diphosphate Ribose; Breast Neoplasms; Female; Humans; Indazoles; Ovarian Neoplasms; Piperidines; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Thiazoles; Thiophenes; Thrombocytopenia | 2020 |
Blockade of metabotropic glutamate receptor 5 attenuates axonal degeneration in 6-hydroxydopamine-induced model of Parkinson's disease.
Topics: Animals; Axons; Calcium Signaling; Cells, Cultured; Excitatory Amino Acid Antagonists; Extracellular Signal-Regulated MAP Kinases; Female; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Thiazoles | 2021 |
UV spectrophotometric methods for quantitative determination of masitinib; extraction of qualitative information.
Topics: Benzamides; Humans; Piperidines; Pyridines; Spectrophotometry; Spectrophotometry, Ultraviolet; Tablets; Thiazoles | 2021 |
Development and progression of proteinuria in dogs treated with masitinib for neoplasia: 28 cases (2010-2019).
Topics: Animals; Benzamides; Creatinine; Dog Diseases; Dogs; Neoplasms; Piperidines; Proteinuria; Pyridines; Thiazoles | 2021 |
In Silico Characterization of Masitinib Interaction with SARS-CoV-2 Main Protease.
Topics: Benzamides; Catalytic Domain; Coronavirus 3C Proteases; Cysteine Proteinase Inhibitors; Hydrogen Bonding; Molecular Dynamics Simulation; Mutation; Piperidines; Protein Binding; Pyridines; SARS-CoV-2; Static Electricity; Thiazoles | 2021 |
mGluR5-Mediated eCB Signaling in the Nucleus Accumbens Controls Vulnerability to Depressive-Like Behaviors and Pain After Chronic Social Defeat Stress.
Topics: Animals; Cannabinoid Receptor Antagonists; Chronic Disease; Depressive Disorder, Major; Endocannabinoids; Male; Mice; Mice, Inbred C57BL; Microinjections; Nucleus Accumbens; Pain; Piperidines; Pyrazoles; Pyridines; Receptor, Metabotropic Glutamate 5; Signal Transduction; Social Defeat; Stress, Psychological; Thiazoles | 2021 |
Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2.
Topics: A549 Cells; Animals; Antiviral Agents; Benzamides; Catalytic Domain; Coronavirus 3C Proteases; Coronavirus OC43, Human; COVID-19; COVID-19 Drug Treatment; Cysteine Proteinase Inhibitors; HEK293 Cells; Humans; Inhibitory Concentration 50; Mice; Mice, Transgenic; Microbial Sensitivity Tests; Piperidines; Pyridines; SARS-CoV-2; Thiazoles; Viral Load; Virus Replication | 2021 |
The pathogenic role of c-Kit+ mast cells in the spinal motor neuron-vascular niche in ALS.
Topics: Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Benzamides; Case-Control Studies; Chymases; Cyclooxygenase 2; Female; Humans; Male; Mast Cells; Mice; Microvessels; Middle Aged; Motor Neurons; Neuroinflammatory Diseases; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyridines; Spinal Cord; Stem Cell Factor; Thiazoles; Tryptases | 2021 |
Dissection of the Enzymatic Process for Forming a Central Imidazopiperidine Heterocycle in the Biosynthesis of a Series
Topics: Amino Acid Sequence; Anti-Bacterial Agents; Micromonospora; Mixed Function Oxygenases; Oxidation-Reduction; Peptides; Piperidines; Streptomyces; Thiazoles | 2021 |
Intra-arterial combination therapy for experimental acute ischemic stroke.
Topics: Animals; Calcium Channel Blockers; Combined Modality Therapy; Infusions, Intra-Arterial; Ischemic Stroke; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Piperidines; Thiazoles; Treatment Outcome; Verapamil | 2022 |
In vivo screening and toxicity studies of indolinone incorporated thiosemicarbazone, thiazole and piperidinosulfonyl moieties as anticonvulsant agents.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Injections, Intraperitoneal; Male; Mice; Molecular Structure; Oxindoles; Pentylenetetrazole; Piperidines; Seizures; Structure-Activity Relationship; Thiazoles; Thiosemicarbazones | 2021 |
ML277 regulates KCNQ1 single-channel amplitudes and kinetics, modified by voltage sensor state.
Topics: Humans; Induced Pluripotent Stem Cells; KCNQ1 Potassium Channel; Kinetics; Myocytes, Cardiac; Piperidines; Potassium Channels, Voltage-Gated; Thiazoles; Tosyl Compounds | 2021 |
Novel NFκB Inhibitor SC75741 Mitigates Chondrocyte Degradation and Prevents Activated Fibroblast Transformation by Modulating miR-21/GDF-5/SOX5 Signaling.
Topics: Animals; Benzimidazoles; Cell Differentiation; Chondrocytes; Collagen Type IV; Disease Models, Animal; Female; Fibroblasts; Gene Expression Regulation; Growth Differentiation Factor 5; Humans; Interleukin-1beta; MicroRNAs; NF-kappa B; Osteoarthritis; Piperidines; Pyrimidines; Rats, Wistar; Signal Transduction; SOXD Transcription Factors; Synovial Membrane; Thiazoles | 2021 |
New series of hydrazinyl thiazole derivatives of piperidin-4-one: Synthesis, structural elucidation, analgesic activity and comparative structure activity relationship.
Topics: Analgesics; Animals; Molecular Structure; Pain; Piperidines; Structure-Activity Relationship; Thiazoles | 2021 |
Additive cell protective and oxidative stress reducing effects of combined treatment with cromolyn sodium and masitinib on MPTP-induced toxicity in SH-SY5Y neuroblastoma cells.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Benzamides; Cell Line, Tumor; Cromolyn Sodium; Cytoprotection; Humans; Oxidative Stress; Piperidines; Pyridines; Thiazoles | 2022 |
Evaluation of the therapeutic potential of masitinib and expression of its specific targets c-Kit, PDGFR-α, PDGFR-β, and Lyn in canine prostate cancer cell lines.
Topics: Adenocarcinoma; Animals; Benzamides; Carcinoma, Transitional Cell; Cell Line; Dog Diseases; Dogs; Male; Piperidines; Prostatic Neoplasms; Proto-Oncogene Proteins c-kit; Pyridines; Receptor, Platelet-Derived Growth Factor alpha; Receptor, Platelet-Derived Growth Factor beta; Thiazoles | 2022 |
Androgen and oestrogen receptor co-expression determines the efficacy of hormone receptor-mediated radiosensitisation in breast cancer.
Topics: Androgen Receptor Antagonists; Androgens; Breast Neoplasms; Cell Line, Tumor; Estrogen Receptor Antagonists; Female; Fulvestrant; Humans; Naphthalenes; Piperidines; Pyrrolidines; Radiation Tolerance; Receptors, Androgen; Receptors, Estrogen; Tamoxifen; Thiazoles; Triazoles | 2022 |
Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277.
Topics: Animals; KCNQ1 Potassium Channel; Long QT Syndrome; Mutation; Piperidines; Thiazoles; Tosyl Compounds; Xenopus | 2022 |
c-kit inhibitor masitinib induces reactive oxygen species-dependent apoptosis in c-kit-negative HepG2 cells.
Topics: Animals; Apoptosis; Benzamides; Cell Line, Tumor; Dogs; Hep G2 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Piperidines; Proto-Oncogene Proteins c-kit; Pyridines; Reactive Oxygen Species; Thiazoles | 2022 |
Cytochromes P450 2C8 and 3A Catalyze the Metabolic Activation of the Tyrosine Kinase Inhibitor Masitinib.
Topics: Activation, Metabolic; Benzamides; Catalysis; COVID-19; Cytochrome P-450 Enzyme System; Humans; Microsomes, Liver; NADP; Piperidines; Potassium Cyanide; Protein Kinase Inhibitors; Pyridines; Thiazoles | 2022 |
Design, Synthesis, and Anti-Inflammatory Evaluation of a Novel PPARδ Agonist with a 4-(1-Pyrrolidinyl)piperidine Structure.
Topics: Animals; Anti-Inflammatory Agents; Atherosclerosis; Mice; Piperidines; PPAR delta; Thiazoles | 2023 |