Page last updated: 2024-08-21

thiazoles and pc190723

thiazoles has been researched along with pc190723 in 24 studies

Research

Studies (24)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (8.33)	29.6817
2010's	21 (87.50)	24.3611
2020's	1 (4.17)	2.80

Authors

Authors	Studies
Payne, DJ	1
Aiwale, ST; Baker, PJ; Barynin, VV; Bennett, JM; Brown, DR; Chauhan, PK; Collins, I; Czaplewski, LG; Errington, J; Galbraith, G; Haydon, DJ; Heal, JR; Rice, DW; Sedelnikova, SE; Sheridan, JM; Srivastava, A; Stokes, NR; Taneja, A; Ure, R	1
Alonso, D; Andreu, JM; Huecas, S; Llorca, O; Lopez-Rodriguez, ML; Martín-Galiano, AJ; Núñez-Ramírez, R; Ruiz-Avila, LB; Schaffner-Barbero, C	1
Beanland, J; Bennett, JM; Brown, D; Chauhan, PK; Collins, I; Czaplewski, L; Galbraith, G; Hall, R; Haydon, DJ; Henstock, V; Lancett, P; Macdonald, R; Nayal, N; Noula, C; Rockley, C; Srivastava, A; Stokes, NR; Sutariya, JK	1
Olmstead, MM; Shaw, JT; Sorto, NA	1
Baryshnikova, A; Benton-Perdomo, L; Caron, A; Claveau, D; Daigneault, E; Deschamps, K; Elsen, NL; Gill, CJ; Kramer, S; Landry, F; Langlois, E; Lebeau-Jacob, C; Lee, SH; Liang, L; Lu, J; Lumb, KJ; Maxwell, E; Meredith, TC; Monteiro, JM; Parthasarathy, G; Pereira, PM; Petcu, M; Pinho, MG; Ramtohul, Y; Reid, JC; Roemer, T; Sharma, S; Sillaots, S; Skorey, K; Soisson, SM; Tam, J; Tan, CM; Therien, AG; Vaillancourt, J; Wang, H; Wang-Jarantow, L; Wong, S; Wu, J	1
Foss, MH; Garstecki, P; Holyst, R; Hou, S; Kaminski, TS; Nieznanski, K; Shaw, JT; Sorto, NA; Tabaka, M; Thanbichler, M; Weibel, DB; Wieczorek, SA; Ziebacz, N	1
Chain, PS; Detter, JC; Dichosa, AE; Fitzsimons, MS; Green, LD; Gu, W; Han, CS; Lo, CC; McMurry, K; Preteska, LG; Snook, JP; Weston, LL; Zhang, X	1
Elsen, NL; Lu, J; Lumb, KJ; Parthasarathy, G; Reid, JC; Sharma, S; Soisson, SM	1
Ames, JB; Anderson, DE; Grove, CI; Kim, MB; Lackner, LL; Moore, JT; O'Brien, TE; Shaw, JT; Sorto, NA	1
Arnold, E; Kaul, M; Kerrigan, JE; Lavoie, EJ; Parhi, AK; Pilch, DS; Tuske, S; Zhang, Y	1
Kaul, M; Lavoie, EJ; Mark, L; Parhi, AK; Pilch, DS; Zhang, Y	2
Kaul, M; Lavoie, EJ; Parhi, AK; Pilch, DS; Zhang, Y	1
Andreu, JM; Chacón, P; López-Blanco, JR; Ramírez-Aportela, E	1
Bissa, M; Bolchi, C; Chiodini, G; De Giuli Morghen, C; Fumagalli, L; Pallavicini, M; Radaelli, A; Ruggeri, P; Straniero, V; Valoti, E; Zanotto, C	1
Altman, RB; Hsin, J; Huang, KC; Liu, T; Miguel, A; Tang, G	1
An, L; Chen, T; Chen, X; Dyson, P; Facey, P; Ju, F; Li, S; Liu, G; Mullins, JG; Ren, C; Xiao, J; Zhang, B	1
Kaul, M; LaVoie, EJ; Lyu, YL; Mark, L; Parhi, AK; Pawlak, J; Pilch, DS; Saravolatz, LD; Saravolatz, S; Weinstein, MP; Zhang, Y	1
Adams, DW; Errington, J; Wu, LJ	1
Hu, Z; Ma, X; Xiang, G; Zhang, S; Zhou, W	1
Fernandes, PB; Ferreira, MT; Filipe, SR; Macário, V; Monteiro, JM; Pereira, AR; Pinho, MG; Reichmann, NT; Santos, M; Saraiva, BM; Tavares, AC; VanNieuwenhze, MS; Veiga, H	1
Hsin, J; Huang, KC; Khare, S; Nepomuceno, GM; Shaw, JT; Shi, H; Sorto, NA	1
Ma, S; Ma, Y; Zhang, L; Zhang, P; Zhang, S; Zhou, L	1

Other Studies

24 other study(ies) available for thiazoles and pc190723

Article	Year
Microbiology. Desperately seeking new antibiotics. Science (New York, N.Y.), 2008, Sep-19, Volume: 321, Issue:5896 Topics: Animals; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Bacterial Proteins; Cytoskeletal Proteins; Drug Design; Drug Resistance, Bacterial; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Histidine Kinase; Humans; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sulfonamides; Thiazoles; Virulence; Virulence Factors; Vitamin K 2	2008
An inhibitor of FtsZ with potent and selective anti-staphylococcal activity. Science (New York, N.Y.), 2008, Sep-19, Volume: 321, Issue:5896 Topics: Amino Acid Sequence; Animals; Anti-Bacterial Agents; Bacillus subtilis; Bacterial Proteins; Binding Sites; Cell Division; Crystallography, X-Ray; Cytoskeletal Proteins; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Ligands; Methicillin Resistance; Mice; Microbial Sensitivity Tests; Models, Molecular; Molecular Sequence Data; Mutation; Protein Conformation; Pyridines; Staphylococcal Infections; Staphylococcus aureus; Thiazoles; Tubulin	2008
The antibacterial cell division inhibitor PC190723 is an FtsZ polymer-stabilizing agent that induces filament assembly and condensation. The Journal of biological chemistry, 2010, May-07, Volume: 285, Issue:19 Topics: Anti-Bacterial Agents; Bacillus subtilis; Bacterial Proteins; Binding Sites; Cell Division; Cytoskeletal Proteins; Excipients; Pyridines; Thiazoles	2010
Creating an antibacterial with in vivo efficacy: synthesis and characterization of potent inhibitors of the bacterial cell division protein FtsZ with improved pharmaceutical properties. Journal of medicinal chemistry, 2010, May-27, Volume: 53, Issue:10 Topics: Animals; Anti-Bacterial Agents; Bacterial Proteins; Biological Availability; Blood Proteins; Caco-2 Cells; Cell Division; Cell Membrane Permeability; Cytoskeletal Proteins; Hepatocytes; Humans; Mice; Microbial Sensitivity Tests; Models, Molecular; Protein Binding; Pyridines; Staphylococcal Infections; Staphylococcus aureus; Structure-Activity Relationship; Thiazoles	2010
Practical synthesis of PC190723, an inhibitor of the bacterial cell division protein FtsZ. The Journal of organic chemistry, 2010, Nov-19, Volume: 75, Issue:22 Topics: Anti-Bacterial Agents; Bacterial Proteins; Cell Division; Cytoskeletal Proteins; Microbial Sensitivity Tests; Pyridines; Staphylococcus aureus; Thiazoles	2010
Restoring methicillin-resistant Staphylococcus aureus susceptibility to β-lactam antibiotics. Science translational medicine, 2012, Mar-21, Volume: 4, Issue:126 Topics: Animals; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactams; Cell Division; Crystallography, X-Ray; Cytoskeletal Proteins; Disease Models, Animal; Drug Resistance, Bacterial; Drug Synergism; Gene Regulatory Networks; Guanosine Diphosphate; Imipenem; Methicillin-Resistant Staphylococcus aureus; Mice; Microbial Sensitivity Tests; Mutation; Protein Structure, Secondary; Protein Transport; Pyridines; Staphylococcal Infections; Thiazoles; Virulence	2012
Characterization of Caulobacter crescentus FtsZ protein using dynamic light scattering. The Journal of biological chemistry, 2012, Jul-06, Volume: 287, Issue:28 Topics: Algorithms; Bacterial Proteins; Caulobacter crescentus; Cytoskeletal Proteins; GTP Phosphohydrolases; Guanosine Diphosphate; Guanosine Triphosphate; Kinetics; Light; Microscopy, Electron, Transmission; Protein Multimerization; Protein Stability; Pyridines; Scattering, Radiation; Solutions; Thiazoles	2012
Artificial polyploidy improves bacterial single cell genome recovery. PloS one, 2012, Volume: 7, Issue:5 Topics: Bacillus subtilis; Cell Division; DNA, Bacterial; Genome, Bacterial; Genomics; Polyploidy; Pyridines; Single-Cell Analysis; Thiazoles	2012
Mechanism of action of the cell-division inhibitor PC190723: modulation of FtsZ assembly cooperativity. Journal of the American Chemical Society, 2012, Aug-01, Volume: 134, Issue:30 Topics: Anti-Bacterial Agents; Bacterial Proteins; Cytoskeletal Proteins; Humans; Molecular Docking Simulation; Protein Conformation; Protein Structure, Tertiary; Pyridines; Staphylococcal Infections; Staphylococcus aureus; Thiazoles	2012
Comparison of small molecule inhibitors of the bacterial cell division protein FtsZ and identification of a reliable cross-species inhibitor. ACS chemical biology, 2012, Nov-16, Volume: 7, Issue:11 Topics: Anti-Bacterial Agents; Bacillus subtilis; Bacteria; Bacterial Infections; Bacterial Proteins; Cytoskeletal Proteins; Escherichia coli; Humans; Pyridines; Small Molecule Libraries; Staphylococcus aureus; Structure-Activity Relationship; Thiazoles	2012
Enterococcal and streptococcal resistance to PC190723 and related compounds: molecular insights from a FtsZ mutational analysis. Biochimie, 2013, Volume: 95, Issue:10 Topics: Amino Acid Sequence; Anti-Bacterial Agents; Bacillus subtilis; Bacterial Proteins; Cytoskeletal Proteins; Drug Resistance, Multiple, Bacterial; Microbial Sensitivity Tests; Molecular Docking Simulation; Molecular Sequence Data; Mutation; Protein Multimerization; Pyridines; Sequence Alignment; Sequence Homology, Amino Acid; Staphylococcus aureus; Thiazoles	2013
An FtsZ-targeting prodrug with oral antistaphylococcal efficacy in vivo. Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:12 Topics: Animals; Anti-Bacterial Agents; Bacterial Proteins; Benzamides; Biological Availability; Biotransformation; Chlorocebus aethiops; Cytoskeletal Proteins; Female; Half-Life; Male; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Prodrugs; Pyridines; Staphylococcal Infections; Thiazoles; Vero Cells	2013
Pharmacokinetics and in vivo antistaphylococcal efficacy of TXY541, a 1-methylpiperidine-4-carboxamide prodrug of PC190723. Biochemical pharmacology, 2013, Dec-15, Volume: 86, Issue:12 Topics: Animals; Anti-Bacterial Agents; Female; Heterocyclic Compounds, 2-Ring; Imides; Mice; Microbial Sensitivity Tests; Prodrugs; Pyridines; Staphylococcus; Thiazoles	2013
Inhibition of RND-type efflux pumps confers the FtsZ-directed prodrug TXY436 with activity against Gram-negative bacteria. Biochemical pharmacology, 2014, Jun-01, Volume: 89, Issue:3 Topics: Acinetobacter baumannii; Animals; Anti-Bacterial Agents; Bacterial Proteins; Benzamides; Cytoskeletal Proteins; Escherichia coli; Gene Expression Regulation, Bacterial; Klebsiella pneumoniae; Microbial Sensitivity Tests; Molecular Structure; Prodrugs; Pyridines; rho GTP-Binding Proteins; Thiazoles	2014
Understanding nucleotide-regulated FtsZ filament dynamics and the monomer assembly switch with large-scale atomistic simulations. Biophysical journal, 2014, Nov-04, Volume: 107, Issue:9 Topics: Anti-Bacterial Agents; Bacterial Proteins; Calcium; Cytoskeletal Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Ions; Magnesium; Methanocaldococcus; Molecular Dynamics Simulation; Nucleotides; Protein Conformation; Protein Stability; Pyridines; Static Electricity; Thiazoles; Video Recording	2014
Benzodioxane-benzamides as new bacterial cell division inhibitors. European journal of medicinal chemistry, 2015, Jan-07, Volume: 89 Topics: Animals; Anti-Bacterial Agents; Bacterial Proteins; Benzamides; Cell Division; Cell Survival; Chlorocebus aethiops; Cytoskeletal Proteins; Dioxanes; Escherichia coli; Microbial Sensitivity Tests; Molecular Structure; Pyridines; Staphylococcus aureus; Structure-Activity Relationship; Thiazoles; Vero Cells	2015
Variations in the binding pocket of an inhibitor of the bacterial division protein FtsZ across genotypes and species. PLoS computational biology, 2015, Volume: 11, Issue:3 Topics: Bacterial Proteins; Binding Sites; Cytoskeletal Proteins; Drug Resistance, Bacterial; Molecular Dynamics Simulation; Pyridines; Staphylococcus aureus; Thiazoles	2015
RfiA, a novel PAP2 domain-containing polytopic membrane protein that confers resistance to the FtsZ inhibitor PC190723. Future microbiology, 2015, Volume: 10, Issue:3 Topics: Arthrobacter; Bacterial Proteins; Benzamides; Cytoskeletal Proteins; Drug Resistance, Bacterial; Membrane Proteins; Microbial Sensitivity Tests; Phylogeny; Pyridines; Thiazoles	2015
TXA709, an FtsZ-Targeting Benzamide Prodrug with Improved Pharmacokinetics and Enhanced In Vivo Efficacy against Methicillin-Resistant Staphylococcus aureus. Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:8 Topics: Animals; Anti-Bacterial Agents; Bacterial Proteins; Benzamides; Cells, Cultured; Cytoskeletal Proteins; Daptomycin; Dogs; Half-Life; Humans; Linezolid; Methicillin; Methicillin Resistance; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Prodrugs; Pyridines; Rats; Staphylococcal Infections; Thiazoles; Vancomycin	2015
A benzamide-dependent ftsZ mutant reveals residues crucial for Z-ring assembly. Molecular microbiology, 2016, Volume: 99, Issue:6 Topics: Anti-Bacterial Agents; Bacillus subtilis; Bacterial Proteins; Benzamides; Binding Sites; Cell Division; Cytoskeletal Proteins; Drug Resistance, Bacterial; Mutagenesis, Site-Directed; Mutation; Pyridines; Staphylococcus aureus; Thiazoles	2016
Synthesis and antibacterial activity of 3-benzylamide derivatives as FtsZ inhibitors. Bioorganic & medicinal chemistry letters, 2017, 04-15, Volume: 27, Issue:8 Topics: Anti-Bacterial Agents; Bacillus subtilis; Benzamides; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Mycobacterium smegmatis; Pyridines; Staphylococcus aureus; Thiazoles	2017
Peptidoglycan synthesis drives an FtsZ-treadmilling-independent step of cytokinesis. Nature, 2018, 02-22, Volume: 554, Issue:7693 Topics: Bacterial Proteins; Cell Wall; Cytokinesis; Cytoskeletal Proteins; Kinetics; Microscopy, Fluorescence; Peptidoglycan; Phospholipid Transfer Proteins; Pyridines; Single-Cell Analysis; Staphylococcus aureus; Thiazoles; Uridine Diphosphate N-Acetylmuramic Acid	2018
FtsZ-Independent Mechanism of Division Inhibition by the Small Molecule PC190723 in Escherichia coli. Advanced biosystems, 2019, Volume: 3, Issue:11 Topics: Bacterial Proteins; Cell Division; Cytoskeletal Proteins; Escherichia coli; Protein Domains; Pyridines; Staphylococcus aureus; Thiazoles	2019
Exploration of the inhibitory mechanism of PC190723 on FtsZ protein by molecular dynamics simulation. Journal of molecular graphics & modelling, 2022, Volume: 114 Topics: Anti-Bacterial Agents; Bacterial Proteins; Cytoskeletal Proteins; Humans; Molecular Dynamics Simulation; Pyridines; Thiazoles	2022