thiazoles has been researched along with oxidopamine in 43 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (13.95) | 18.2507 |
| 2000's | 23 (53.49) | 29.6817 |
| 2010's | 13 (30.23) | 24.3611 |
| 2020's | 1 (2.33) | 2.80 |
| Authors | Studies |
|---|---|
| Buxser, SE; Decker, DE; Vroegop, SM | 1 |
| Fibiger, HC; Jakubovic, A; Robertson, GS; Tham, CS; Wilson, C | 1 |
| Barnéoud, P; Boireau, A; Doble, A; Dubédat, P; Mazadier, M; Miquet, JM; Parmentier, S | 1 |
| d'Agostini, F; Damsma, G; DaPrada, M; DeBoer, P; Heeringa, MJ | 1 |
| Cano-Abad, MF; Gandía, L; García, AG; Hernández-Guijo, JM; López, MG; Sánchez-García, P; Zapater, P | 1 |
| Gleason, WB; Johnson, RL; Khalil, EM; Mishra, RK; Ojala, WH; Pradhan, A | 1 |
| Carvey, PM; Chen, EY; Ling, ZD; Lipton, JW; Ma, SY; Robie, HC; Tong, CW; Vu, TQ | 1 |
| Ferger, B; Mierau, J; Teismann, P | 1 |
| Brannan, T; Prikhojan, A; Yahr, MD | 1 |
| Appel, SH; Jankovic, J; Le, WD; Xie, W | 1 |
| Cao, Y; Jin, C; Nie, G; Shen, S; Zhao, B | 1 |
| Andrén, PE; Arts, J; Gunne, L; Jongsma, M; Klintenberg, R; Wikström, H | 1 |
| Albin, RL; Desmond, TJ; Frey, KA; Kemmerer, ES; Kilbourn, MR | 1 |
| Jin-fa, G; Lan-yin, S; Ming, Z; Xin-yuan, L; Zhi-shun, L | 1 |
| Akaike, A; Izumi, Y; Katsuki, H; Kume, T; Sakka, N; Sawada, H; Shimohama, S; Yamamoto, N | 1 |
| Chung, KC; Kim, J; Lee, CH; Lee, HJ; Lee, ST; Oh, YJ; Paik, SR; Park, SM; Sung, JY; Um, JW | 1 |
| Asanuma, M; Diaz-Corrales, FJ; Miyazaki, I; Ogawa, N; Shimizu, M; Tanaka, K | 1 |
| Bezard, E; Guo, S; Zhao, B | 1 |
| Cenci, MA; Danysz, W; Dekundy, A; Pietraszek, M; Schaefer, D | 1 |
| Hu, Y; Huang, W; Li, S; Liu, H; Wang, L; Xiao, J; Zhao, L; Zhong, W | 1 |
| Lehtonen, S; Männistö, PT; Puttonen, KA; Raasmaja, A | 1 |
| Amit, T; Bar-Am, O; Youdim, MB | 1 |
| Jiang, H; Song, N; Wang, J; Xie, JX | 1 |
| Comella, JX; Concannon, CG; Fernandez-Gomez, FJ; Galindo, MF; Gomez-Lazaro, M; Jordan, J; Llecha, N; Prehn, JH; Segura, MF | 1 |
| Kääriäinen, TM; Kekki, H; Lecklin, A; Lehtonen, S; Männistö, PT; Nenonen, T; Ossola, B; Piltonen, M; Raasmaja, A | 1 |
| Ariga, H; Iguchi-Ariga, S; Miyazaki, S; Nakano, M; Nunome, K | 1 |
| Chan, P; Wang, L; Xu, S; Xu, X | 1 |
| Bilici, N; Gören, B; Korfali, E; Mimbay, Z; Oğul, E; Zarifoğlu, M | 1 |
| Handforth, A; Micevych, P; Quesada, A | 1 |
| Li, Y; Liu, Z; Luo, F; Wei, L; Xu, P | 1 |
| Auguet, M; Chabrier, PE; Ferrandis, E; Grandoulier, AS; Marin, JG; Mautino, G; Rocher, MN; Spinnewyn, B | 1 |
| Binaglia, L; Calabresi, P; Chiasserini, D; de Iure, A; Koya, K; Orvietani, PL; Susta, F; Tantucci, M; Tozzi, A | 1 |
| Behr, GA; da Motta, LL; da Rocha, JB; de Medeiros, LM; de Oliveira, VA; Ibrahim, M; Klamt, F; Londero, GF; Lopes, FM; Moreira, JC; Porciúncula, LO | 1 |
| Konitsiotis, S; Maranis, S; Stamatis, D; Tsironis, C | 1 |
| Gupta, A; Kalonia, H; Kumar, A; Mishra, J; Sharma, N | 1 |
| Chang, SW; Chen, JH; Lin, CY; Lin, FJ; Ou, HP; Tsai, CW; Wu, CR | 1 |
| Dutta, A; Johnson, M; Santra, S; Shah, M; Xu, L | 1 |
| Alcacer, C; Bimpisidis, Z; Cenci, MA; Engblom, D; Fieblinger, T; Maslava, N; Sandberg, S; Sebastianutto, I | 1 |
| Andersen, JK; Beal, F; Dutta, AK; Rajagopalan, S; Shah, M; Shurubor, Y; Voshavar, C; Xu, L | 1 |
| Dutta, AK; Shah, M; Voshavar, C; Xu, L | 1 |
| Chassain, C; Durif, F; Hafidi, A; Ouachikh, O; Pagès, G | 1 |
| Agrawal, S; Kumari, N; Kumari, R; Luthra, PM; Sharma, D | 1 |
| Gu, L; Huang, YL; Wang, Y; Yang, HM; Zhang, H; Zhang, JN | 1 |
43 other study(ies) available for thiazoles and oxidopamine
| Article | Year |
|---|---|
Localization of damage induced by reactive oxygen species in cultured cells.
Topics: Aminoisobutyric Acids; Animals; Benzene Derivatives; Biological Transport, Active; Cell Line; Cell Membrane; Glucose; Hybridomas; Hydrogen Peroxide; Mice; Mitochondria; Oxidopamine; Rats; Reactive Oxygen Species; Staining and Labeling; Tetrazolium Salts; Thiazoles | 1995 |
In vivo comparisons of the effects of quinpirole and the putative presynaptic dopaminergic agonists B-HT 920 and SND 919 on striatal dopamine and acetylcholine release.
Topics: Acetylcholine; Animals; Azepines; Benzothiazoles; Corpus Striatum; Dopamine; Dopamine Agents; Ergolines; Male; Oxidopamine; Pramipexole; Quinpirole; Raclopride; Rats; Rats, Wistar; Receptors, Dopamine; Salicylamides; Thiazoles | 1993 |
Neuroprotective effects of riluzole on a model of Parkinson's disease in the rat.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amphetamine; Animals; Apomorphine; Brain Chemistry; Central Nervous System Stimulants; Conditioning, Operant; Dopamine Agonists; Female; Male; Neuroprotective Agents; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Inbred Strains; Riluzole; Stereotyped Behavior; Substantia Nigra; Sympatholytics; Thiazoles | 1996 |
Effect of monoamine oxidase A and B and of catechol-O-methyltransferase inhibition on L-DOPA-induced circling behavior.
Topics: Animals; Antiparkinson Agents; Benzophenones; Catechol O-Methyltransferase Inhibitors; Enzyme Inhibitors; Levodopa; Male; Monoamine Oxidase Inhibitors; Motor Activity; Nitrophenols; Oxidopamine; Picolinic Acids; Rats; Rotation; Thiazoles; Tolcapone | 1997 |
Effects of the neuroprotectant lubeluzole on the cytotoxic actions of veratridine, barium, ouabain and 6-hydroxydopamine in chromaffin cells.
Topics: Adrenal Glands; Animals; Barium; Calcium; Cattle; Chromaffin Cells; Cytosol; Neuroprotective Agents; Ouabain; Oxidopamine; Penfluridol; Piperidines; Sodium; Thiazoles; Veratridine | 1998 |
Synthesis and dopamine receptor modulating activity of substituted bicyclic thiazolidine lactam peptidomimetics of L-prolyl-L-leucyl-glycinamide.
Topics: Animals; Crystallography, X-Ray; Dopamine Agents; Lactams; Male; Models, Molecular; Molecular Mimicry; Molecular Structure; MSH Release-Inhibiting Hormone; Oxidopamine; Parkinson Disease, Secondary; Pyrrolidines; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Structure-Activity Relationship; Thiazoles; Thiazolidines | 1999 |
Pramipexole attenuates the dopaminergic cell loss induced by intraventricular 6-hydroxydopamine.
Topics: Animals; Benzothiazoles; Cell Count; Cell Death; Dopamine; Dopamine Agonists; Male; Neostriatum; Nerve Degeneration; Neurons; Neuroprotective Agents; Oxidopamine; Parkinsonian Disorders; Pramipexole; Rats; Rats, Sprague-Dawley; Substantia Nigra; Thiazoles | 2000 |
The dopamine agonist pramipexole scavenges hydroxyl free radicals induced by striatal application of 6-hydroxydopamine in rats: an in vivo microdialysis study.
Topics: Adrenergic Agents; Animals; Benzothiazoles; Corpus Striatum; Dopamine; Dopamine Agonists; Hydroxybenzoates; Hydroxyl Radical; Male; Microdialysis; Oxidopamine; Pergolide; Pramipexole; Rats; Rats, Wistar; Thiazoles | 2000 |
Comparative effects of repeated administration of dopamine agonists on circling behavior in rats.
Topics: Animals; Benzothiazoles; Brain; Bromocriptine; Cabergoline; Dopamine Agonists; Drug Administration Schedule; Ergolines; Indoles; Male; Motor Activity; Oxidopamine; Parkinsonian Disorders; Pergolide; Pramipexole; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Dopamine D1; Receptors, Dopamine D2; Thiazoles | 2000 |
Antioxidant property of pramipexole independent of dopamine receptor activation in neuroprotection.
Topics: Animals; Antioxidants; Benzothiazoles; Cell Line; Cell Survival; Dopamine; Dopamine D2 Receptor Antagonists; Hydrogen Peroxide; Neurons; Neuroprotective Agents; Oxidative Stress; Oxidopamine; Parkinson Disease; Pramipexole; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Thiazoles | 2000 |
Distinct effects of tea catechins on 6-hydroxydopamine-induced apoptosis in PC12 cells.
Topics: Adrenergic Agents; Animals; Apoptosis; Beverages; Catechin; Cell Nucleus; Cell Survival; Coloring Agents; DNA Fragmentation; Dose-Response Relationship, Drug; Electrophoresis, Agar Gel; Flavonoids; Flow Cytometry; Models, Chemical; Oxidopamine; PC12 Cells; Phenols; Polymers; Rats; Tetrazolium Salts; Thiazoles | 2002 |
Motor effects of a dopamine stabilizer (GMC1111) in primate models of Parkinson and hemiparkinsonism.
Topics: Animals; Callithrix; Disease Models, Animal; Dopamine; Dyskinesias; Female; Indans; Male; Motor Activity; Oxidopamine; Parkinson Disease; Prosencephalon; Thiazoles | 2003 |
Treatment effects on nigrostriatal projection integrity in partial 6-OHDA lesions: comparison of L-DOPA and pramipexole.
Topics: Amphetamine; Animals; Antiparkinson Agents; Apomorphine; Autoradiography; Behavior, Animal; Benzothiazoles; Binding, Competitive; Corpus Striatum; Disease Models, Animal; Levodopa; Male; Membrane Glycoproteins; Membrane Transport Proteins; Motor Activity; Neuropeptides; Oxidopamine; Parkinsonian Disorders; Pramipexole; Rats; Rats, Sprague-Dawley; Substantia Nigra; Thiazoles; Treatment Outcome; Tritium; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2003 |
Co-treatment with ethanol enhances the toxicity of 6-hydroxydopamine.
Topics: Adrenergic Agents; Animals; Apoptosis; Cell Line; Cell Survival; Central Nervous System Depressants; Dose-Response Relationship, Drug; Drug Synergism; Ethanol; Flow Cytometry; Humans; Neuroblastoma; Oxidopamine; Rats; Tetrazolium Salts; Thiazoles | 2004 |
p-Quinone mediates 6-hydroxydopamine-induced dopaminergic neuronal death and ferrous iron accelerates the conversion of p-quinone into melanin extracellularly.
Topics: Analysis of Variance; Animals; Antioxidants; Benzoquinones; Bisbenzimidazole; Caspase 3; Caspases; Cell Death; Cell Survival; Cells, Cultured; Chromatography, High Pressure Liquid; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Electrochemistry; Humans; Hydrogen Peroxide; Immunohistochemistry; Iron; L-Lactate Dehydrogenase; Melanins; Mesencephalon; Models, Biological; Neuroblastoma; Neurons; Oxidopamine; Rats; Reactive Oxygen Species; Tetrazolium Salts; Thiazoles; Time Factors; Tyrosine 3-Monooxygenase | 2005 |
Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases.
Topics: alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blotting, Western; Catalytic Domain; Cell Line, Tumor; Cell Survival; Coloring Agents; Culture Media; Dopamine; Humans; Immunohistochemistry; Insecta; Kinetics; Male; Matrix Metalloproteinase 3; Matrix Metalloproteinases; Nerve Tissue Proteins; Nitric Oxide; Nitrites; Oxidopamine; Oxygen; Parkinson Disease; Protein Binding; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Substantia Nigra; Synucleins; Tetrazolium Salts; Thiazoles; Time Factors; Transfection | 2005 |
Pramipexole has ameliorating effects on levodopa-induced abnormal dopamine turnover in parkinsonian striatum and quenching effects on dopamine-semiquinone generated in vitro.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Antiparkinson Agents; Benzoquinones; Benzothiazoles; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Electron Spin Resonance Spectroscopy; Functional Laterality; Homovanillic Acid; Levodopa; Male; Mice; Mice, Inbred ICR; Oxidopamine; Parkinson Disease; Pramipexole; Thiazoles; Time Factors | 2005 |
Protective effect of green tea polyphenols on the SH-SY5Y cells against 6-OHDA induced apoptosis through ROS-NO pathway.
Topics: Annexin A5; Apoptosis; Blotting, Western; Calcium; Cell Line, Tumor; Cell Survival; Coloring Agents; Dose-Response Relationship, Drug; Flavonoids; Flow Cytometry; Free Radicals; Guanosine Triphosphate; Humans; Membrane Potentials; Mitochondria; Models, Biological; Neurons; Nitric Oxide; Oxidopamine; Oxygen; Parkinson Disease; Phenols; Polyphenols; Quinones; Reactive Oxygen Species; Tea; Tetrazolium Salts; Thiazoles; Time Factors; Tyrosine | 2005 |
Effects of group I metabotropic glutamate receptors blockade in experimental models of Parkinson's disease.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Behavior, Animal; Catalepsy; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Dyskinesias; Functional Laterality; Haloperidol; Levodopa; Male; Motor Activity; Oxidopamine; Parkinson Disease; Pyridines; Quinolines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Rotarod Performance Test; Thiazoles; Time Factors | 2006 |
FK506-binding protein ligands: structure-based design, synthesis, and neurotrophic/neuroprotective properties of substituted 5,5-dimethyl-2-(4-thiazolidine)carboxylates.
Topics: Animals; Autonomic Nervous System Diseases; Chick Embryo; Databases, Factual; Drug Design; Ganglia, Spinal; Humans; In Vitro Techniques; Ligands; Mice; Models, Molecular; Neurites; Neuroprotective Agents; Oxidopamine; Protein Binding; Pyridines; Structure-Activity Relationship; Tacrolimus Binding Protein 1A; Tacrolimus Binding Proteins; Thiazoles | 2006 |
A prolyl oligopeptidase inhibitor, Z-Pro-Prolinal, inhibits glyceraldehyde-3-phosphate dehydrogenase translocation and production of reactive oxygen species in CV1-P cells exposed to 6-hydroxydopamine.
Topics: Actins; Blotting, Western; Cell Line; Cell Survival; Cytarabine; Dipeptides; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Oxidopamine; Prolyl Oligopeptidases; Protease Inhibitors; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Pyrrolidines; Reactive Oxygen Species; Serine Endopeptidases; Tetrazolium Salts; Thiazoles; Tumor Suppressor Protein p53 | 2006 |
Aminoindan and hydroxyaminoindan, metabolites of rasagiline and ladostigil, respectively, exert neuroprotective properties in vitro.
Topics: Animals; Apoptosis; bcl-X Protein; Blotting, Western; Cell Line; Cell Survival; Humans; Indans; Neurons; Neuroprotective Agents; Oxidopamine; PC12 Cells; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Rats; Sympatholytics; Tetrazolium Salts; Thiazoles | 2007 |
Divalent metal transporter 1 up-regulation is involved in the 6-hydroxydopamine-induced ferrous iron influx.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Analysis of Variance; Animals; Cation Transport Proteins; CD11b Antigen; Cell Count; Cells, Cultured; Ferric Compounds; Fluoresceins; Glial Fibrillary Acidic Protein; Iron; Iron-Regulatory Proteins; Mice; Neuroglia; Neurons; Oxidopamine; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Substantia Nigra; Sympatholytics; Tetrazolium Salts; Thiazoles; Up-Regulation | 2007 |
6-Hydroxydopamine activates the mitochondrial apoptosis pathway through p38 MAPK-mediated, p53-independent activation of Bax and PUMA.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Cell Line, Tumor; Enzyme Inhibitors; Fibroblasts; Green Fluorescent Proteins; Humans; Imidazoles; Mice; Mice, Knockout; Mitochondria; Mitochondrial Swelling; Neuroblastoma; Neurons; Oxidopamine; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins; Sympatholytics; Thiazoles; Transfection; Tumor Suppressor Protein p53 | 2008 |
Lack of robust protective effect of quercetin in two types of 6-hydroxydopamine-induced parkinsonian models in rats and dopaminergic cell cultures.
Topics: Amphetamine; Animals; Antioxidants; Apomorphine; Behavior, Animal; Cell Line, Tumor; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Humans; L-Lactate Dehydrogenase; Male; Motor Activity; Neuroblastoma; Oxidopamine; Parkinson Disease; Quercetin; Rats; Rats, Wistar; Substantia Nigra; Tetrazolium Salts; Thiazoles; Tyrosine 3-Monooxygenase | 2008 |
Pyrroloquinoline quinone prevents oxidative stress-induced neuronal death probably through changes in oxidative status of DJ-1.
Topics: Animals; Antioxidants; Ascorbic Acid; Blotting, Western; Cell Death; Cell Survival; Dose-Response Relationship, Drug; Female; Hydrogen Peroxide; Microtubule-Associated Proteins; Neurons; Oxidants; Oxidation-Reduction; Oxidative Stress; Oxidopamine; Pregnancy; Protein Binding; Protein Deglycase DJ-1; Pyrroles; Quinolines; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured; Vitamin E | 2008 |
(-)-Epigallocatechin-3-Gallate protects SH-SY5Y cells against 6-OHDA-induced cell death through STAT3 activation.
Topics: Adrenergic Agents; Analysis of Variance; Catechin; Cell Death; Cell Differentiation; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Interactions; Humans; Neuroblastoma; Neuroprotective Agents; Oxidopamine; STAT3 Transcription Factor; Tetrazolium Salts; Thiazoles; Thymidine; Time Factors; Tritium; Tyrosine | 2009 |
Investigation of neuroprotective effects of cyclooxygenase inhibitors in the 6-hydroxydopamine induced rat Parkinson model.
Topics: Amphetamines; Animals; Antiparkinson Agents; Apomorphine; Aspirin; Behavior, Animal; Cyclooxygenase Inhibitors; Disease Models, Animal; Female; Immunohistochemistry; Meloxicam; Neuroprotective Agents; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Sympatholytics; Thiazines; Thiazoles | 2009 |
C-terminal mechano growth factor protects dopamine neurons: a novel peptide that induces heme oxygenase-1.
Topics: Animals; Cell Line; DNA Fragmentation; Dopamine; Enzyme Induction; Heme Oxygenase-1; Insulin-Like Growth Factor I; Membrane Potentials; Mitochondrial Membranes; Neostriatum; Neurons; Neuroprotective Agents; Oxidopamine; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; STAT5 Transcription Factor; Substantia Nigra; Sympatholytics; Tetrazolium Salts; Thiazoles; Tumor Suppressor Proteins; Up-Regulation | 2009 |
Knockdown of glycogen synthase kinase 3 beta attenuates 6-hydroxydopamine-induced apoptosis in SH-SY5Y cells.
Topics: Adrenergic Agents; Analysis of Variance; Apoptosis; Caspases; Cell Count; Cell Line, Tumor; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Neuroblastoma; Oxidopamine; RNA, Small Interfering; Tetrazolium Salts; Thiazoles; Time Factors | 2011 |
BN82451 attenuates L-dopa-induced dyskinesia in 6-OHDA-lesioned rat model of Parkinson's disease.
Topics: Animals; Area Under Curve; Behavior, Animal; Chromatography, High Pressure Liquid; Corpus Striatum; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Gene Expression; Levodopa; Male; Neuroprotective Agents; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles | 2011 |
Mortalin inhibition in experimental Parkinson's disease.
Topics: Action Potentials; Animals; Antiparasitic Agents; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electron Transport Complex I; Gene Expression Regulation; HSP70 Heat-Shock Proteins; In Vitro Techniques; Male; Neurons; Oxidopamine; Parkinson Disease; Proteomics; Pyridines; Rats; Rats, Wistar; Thiazoles | 2011 |
Evaluation of the neurotoxic/neuroprotective role of organoselenides using differentiated human neuroblastoma SH-SY5Y cell line challenged with 6-hydroxydopamine.
Topics: Antioxidants; Antiparkinson Agents; Cell Differentiation; Cell Line, Tumor; Cell Survival; Coloring Agents; Free Radical Scavengers; Glutathione; Humans; Neurites; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Organoselenium Compounds; Oxidopamine; Sympatholytics; Tetrazolium Salts; Thiazoles | 2012 |
Investigation of the antidyskinetic site of action of metabotropic and ionotropic glutamate receptor antagonists. Intracerebral infusions in 6-hydroxydopamine-lesioned rats with levodopa-induced dyskinesia.
Topics: Animals; Anti-Dyskinesia Agents; Disease Models, Animal; Dyskinesia, Drug-Induced; Excitatory Amino Acid Antagonists; Infusions, Intraventricular; Levodopa; Male; Oxidopamine; Phenols; Piperidines; Putamen; Quinoxalines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Substantia Nigra; Subthalamic Nucleus; Thiazoles | 2012 |
Neuroprotective potential of atorvastatin and simvastatin (HMG-CoA reductase inhibitors) against 6-hydroxydopamine (6-OHDA) induced Parkinson-like symptoms.
Topics: Amphetamine; Analysis of Variance; Animals; Atorvastatin; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Glutathione; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-6; Male; Malondialdehyde; Mitochondria; Motor Activity; NADH Dehydrogenase; Nitrites; Oxidopamine; Parkinsonian Disorders; Pyrroles; Rats; Rats, Wistar; Simvastatin; Tetrazolium Salts; Thiazoles; Tumor Necrosis Factor-alpha | 2012 |
Carnosic acid prevents 6-hydroxydopamine-induced cell death in SH-SY5Y cells via mediation of glutathione synthesis.
Topics: Abietanes; Antioxidants; Apoptosis; Buthionine Sulfoximine; Cell Line; Down-Regulation; Glutamate-Cysteine Ligase; Glutathione; Humans; JNK Mitogen-Activated Protein Kinases; NF-E2-Related Factor 2; Oxidopamine; p38 Mitogen-Activated Protein Kinases; Plant Extracts; Reactive Oxygen Species; Signal Transduction; Tetrazolium Salts; Thiazoles | 2012 |
D-512 and D-440 as novel multifunctional dopamine agonists: characterization of neuroprotection properties and evaluation of in vivo efficacy in a Parkinson's disease animal model.
Topics: Animals; Carotenoids; Disease Models, Animal; Dopamine Agonists; Indoles; Lycopene; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Proto-Oncogene Proteins c-akt; Rats; Thiazoles; Tumor Cells, Cultured | 2013 |
Mechanisms of dopamine D1 receptor-mediated ERK1/2 activation in the parkinsonian striatum and their modulation by metabotropic glutamate receptor type 5.
Topics: Adrenergic Agents; Animals; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oxidopamine; Parkinson Disease; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Dopamine D1; Thiazoles; Tyrosine 3-Monooxygenase | 2014 |
The high-affinity D2/D3 agonist D512 protects PC12 cells from 6-OHDA-induced apoptotic cell death and rescues dopaminergic neurons in the MPTP mouse model of Parkinson's disease.
Topics: Animals; Apoptosis; Cell Death; Dopaminergic Neurons; Dose-Response Relationship, Drug; Indoles; Male; Mice; Mice, Inbred C57BL; Oxidopamine; Parkinsonian Disorders; PC12 Cells; Rats; Reactive Oxygen Species; Receptors, Dopamine D2; Receptors, Dopamine D3; Thiazoles | 2014 |
Assessment of Protective Role of Multifunctional Dopamine Agonist D-512 Against Oxidative Stress Produced by Depletion of Glutathione in PC12 Cells: Implication in Neuroprotective Therapy for Parkinson's Disease.
Topics: Animals; Caspases; Cell Survival; Dopamine Agonists; Dopaminergic Neurons; Extracellular Signal-Regulated MAP Kinases; Glutamate-Cysteine Ligase; Glutathione; Indoles; JNK Mitogen-Activated Protein Kinases; Neuroprotective Agents; Oxidative Stress; Oxidopamine; Parkinson Disease; PC12 Cells; Rats; Signal Transduction; Thiazoles | 2015 |
mGlu5 receptor antagonist blocks bromocriptine-induced conditioned place preference in bilateral mesolimbic-lesioned rat.
Topics: Adrenergic Agents; Adrenergic Uptake Inhibitors; Animals; Antiparkinson Agents; Bromocriptine; Conditioning, Operant; Desipramine; Excitatory Amino Acid Antagonists; Exploratory Behavior; Gene Expression Regulation; Male; Maze Learning; Nucleus Accumbens; Oxidopamine; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Reinforcement, Psychology; Thiazoles; Ventral Tegmental Area | 2017 |
Neuroprotective effect of IDPU (1-(7-imino-3-propyl-2,3-dihydrothiazolo [4,5-d]pyrimidin-6(7H)-yl)urea) in 6-OHDA induced rodent model of hemiparkinson's disease.
Topics: Animals; Antiparkinson Agents; Behavior, Animal; Depression; Disease Models, Animal; Male; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Parkinsonian Disorders; Rats, Wistar; Reactive Oxygen Species; Rotarod Performance Test; Thiazoles; Tyrosine 3-Monooxygenase; Urea | 2018 |
Blockade of metabotropic glutamate receptor 5 attenuates axonal degeneration in 6-hydroxydopamine-induced model of Parkinson's disease.
Topics: Animals; Axons; Calcium Signaling; Cells, Cultured; Excitatory Amino Acid Antagonists; Extracellular Signal-Regulated MAP Kinases; Female; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Thiazoles | 2021 |