thiazoles has been researched along with oxazoles in 351 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 53 (15.10) | 18.7374 |
| 1990's | 45 (12.82) | 18.2507 |
| 2000's | 110 (31.34) | 29.6817 |
| 2010's | 123 (35.04) | 24.3611 |
| 2020's | 20 (5.70) | 2.80 |
| Authors | Studies |
|---|---|
| Fotsch, C; St Jean, DJ | 1 |
| Carbone, D; Cascioferro, S; Cirrincione, G; Diana, P; Giovannetti, E; Parrino, B; Schillaci, D | 1 |
| Breuer, E; Golander, Y; Sarel, S | 1 |
| Reichardt, LF; Ross, WN | 1 |
| Strumwasser, F; Woolum, JC | 1 |
| Dahlbom, R; Moses, P | 1 |
| Smith, LR; Wilkinson, CF | 1 |
| Berlin, KD; Chesnut, RW; Durham, NN; Hashem, MM | 1 |
| Dove, PA; Rosenthale, ME; Sandor, A; Shriver, DA; White, CB | 1 |
| Schulze, W | 1 |
| Günther, O; Hartke, K | 1 |
| Ambrus, G; Barta, I | 1 |
| Lewis, JR | 5 |
| Glazer, AN; Haugland, RP; Mathies, RA; Quesada, MA; Rye, HS; Wemmer, DE; Yue, S | 1 |
| Inoue, Y; Kondo, H; Sakamoto, F; Taguchi, M; Tsukamoto, G | 1 |
| Doble, A; Hubert, JP | 1 |
| Catt, JD; Eison, MS; Lobeck, WG; Minielli, JL; New, JS; Riblet, LA; Smith, DW; Taylor, DP; Temple, DL; Yevich, JP | 1 |
| Kuroiwa, Y; Misawa, S; Tanaka, E | 1 |
| Konnerth, A; Orkand, RK | 1 |
| Rosskamp, E | 1 |
| Bolt, AG; Ghosh, PB | 1 |
| Corriveau, G; Denzer, M; Galantay, EE; Knorr, DC; Paolella, NA; Simpson, R; Strohschein, RJ; Uike, Y | 1 |
| Duclos, JM; Haake, P | 1 |
| Boris, A; Scott, JW | 1 |
| Johnson, GA; Kim, EG | 1 |
| Feinauer, R | 1 |
| Impicciatore, M; Laureri, CF; Mossini, F; Piccinin, GL | 1 |
| Gaetani, E; Laureri, CF | 1 |
| Ponsold, K; Preibsch, W | 1 |
| Fukunaga, M; Kamioka, T; Kawano, Y; Miyadera, T; Tachikawa, R; Takagi, H; Tamura, C; Terada, A | 1 |
| Barrett, GC | 1 |
| Bertaccini, G; Impicciatore, M; Vitali, T | 1 |
| Bausher, LP; Haake, P; McNeal, JP | 1 |
| Nuhn, P; Wagner, G | 1 |
| Brown, K; Cavalla, JF; Green, D; Wilson, AB | 1 |
| Aure, JC; Tveter, L | 1 |
| Goodman, M; Niu, GC; Su, K | 1 |
| Demetrescu, C; Manu, V; Răcăşanu, R | 1 |
| Bexell, G; Lindberg, UH; Pedersen, J; Ross, S | 1 |
| Lindberg, UH | 2 |
| Bexell, G; Lindberg, UH; Ulff, B | 1 |
| Dunoff, RY; Graboyes, H; Jaffe, G; Karash, CB; Pachter, IJ; Snader, K; Weinstock, J | 1 |
| Izumi, K; Murakami, S; Yoshina, S | 1 |
| Doorenbos, NJ; Dorn, CP | 1 |
| Kobinger, W; Pichler, L | 1 |
| de Jonge, A; Innemee, HC; Timmermans, PB; van Meel, JC; van Zwieten, PA | 1 |
| Hammer, R; Kobinger, W; Pichler, L | 1 |
| Kobinger, W; Lillie, C; Pichler, L | 1 |
| Heiny, JA; Vergara, J | 1 |
| Böttcher, I; Klose, W; Niedballa, U; Schwarz, K | 1 |
| Ashoor, SH; Lewis, BJ; Monte, WC | 1 |
| Kamiya, S; Miyahara, M; Nakadate, M; Sueyoshi, S; Tanno, M | 1 |
| Kuno, A; Ohkubo, M; Sakai, H; Takasugi, H | 1 |
| Akasaka, K; Horie, T; Kagaya, T; Kubota, A; Nagato, S; Naitoh, T | 1 |
| Artico, M; Corelli, F; Corrias, S; De Montis, A; La Colla, P; Loi, AG; Mai, A; Marongiu, ME; Massa, S; Ragno, R | 1 |
| Furihata, K; Hidaka, T; Seto, H; Yun, BS | 1 |
| Höfle, G; Hunsmann, G; Jansen, R; Jurkiewicz, E; Kunze, B; Pridzun, L; Reichenbach, H | 1 |
| Cetenko, WA; Connor, DT; Dyer, RD; Kostlan, CR; Schrier, DJ; Sircar, JC; Sorenson, RJ; Unangst, PC; Wright, CD | 1 |
| Broom, NJ; Elder, JS; Hannan, PC; O'Hanlon, PJ; Pons, JE; Walker, G; Wilson, J; Woodall, P | 1 |
| Carlson, RP; Glaser, K; Grimes, D; Gunawan, I; Hartman, DA; Howell, R; Kanzelberger, M; Malamas, MS; Nelson, JA; Shah, U | 1 |
| Freund, P; Heitzmann, T; Neidlein, R; Reiff, K; Strein, K | 1 |
| Ishibashi, M; Kobayashi, J; Kondo, K; Ohizumi, Y; Park, YH; Rho, MC; Sasaki, S | 1 |
| Akasaka, K; Kagaya, T; Kajiwara, A; Kubota, A; Nagato, S | 1 |
| Clark, DA; Genereux, PE; Gibbs, EM; Hulin, B; Lewis, DM; Newton, LS | 1 |
| Kolter, R; Li, YM; Madison, LL; Milne, JC; Walsh, CT | 1 |
| Horie, T; Kagei, Y; Kakiki, M; Kawaguchi, S; Naitoh, T | 1 |
| Andoh, T; Horie, T; Kagei, K; Kakiki, M; Kawaguchi, S; Matsui, K; Mishima, M; Naitoh, T; Yuzuriha, T | 1 |
| Horie, T; Kakiki, M; Kozaki, T; Mishima, M; Naitoh, T; Yuzuriha, T | 1 |
| Eto, M; Hirashima, A; Pan, C; Taniguchi, E; Tomita, J | 1 |
| Cacciaguerra, S; Delarge, J; Depovere, P; Isa, M; Masereel, B; Poupaert, JH; Spampinato, S; Stables, JP; Ucar, H; Van derpoorten, K | 1 |
| Horie, T; Kajiwara, A; Kakiki, M; Kawaguchi, S; Naitoh, T; Ohe, H | 1 |
| Belshaw, PJ; Kelleher, NL; Roy, RS; Walsh, CT | 1 |
| Eliot, AC; Kelleher, NL; Milne, JC; Walsh, CT | 1 |
| Aicher, TD; Balkan, B; Bell, PA; Brand, LJ; Cheon, SH; Deems, RO; Fell, JB; Fillers, WS; Fraser, JD; Gao, J; Kahle, GG; Knorr, DC; Leone, CL; Nadelson, J; Simpson, R; Smith, HC | 1 |
| Blanchard, SG; Boswell, GE; Charifson, PS; Cobb, JE; Collins, JL; Gray-Nunez, Y; Henke, BR; Hull-Ryde, EA; Kazmierski, WM; Lake, DH; Leesnitzer, LM; Lehmann, J; Lenhard, JM; Orband-Miller, LA; Parks, DJ; Plunkett, KD; Tong, WQ | 1 |
| Gundlach, AL; Hosseini, AR; Iakovidis, D; Jackman, GP; King, PR; Louis, WJ; Nero, TL; Suzuki, S | 1 |
| Gundlach, AL; Hosseini, AR; Jackman, GP; King, PR; Louis, WJ | 1 |
| Gronewold, TM; Lünsdorf, H; Reichenbach, H; Sasse, F | 1 |
| Boden, CD; Pattenden, G | 1 |
| Aron, ZD; Fink, BE; Katzenellenbogen, JA; Mortensen, DS; Stauffer, SR | 1 |
| Bornemeier, DA; Chan, K; Connor, DT; Doubleday, R; Dyer, RD; Gilbertsen, RB; Guglietta, A; Roth, BD; Schrier, DJ; Sercel, AD; Song, Y; Sorenson, RJ; Unangst, PC | 1 |
| Eliot, AC; Kelleher, NL; Milne, JC; Nickels, B; Roy, RS; Walsh, CT; Wokhlu, A | 1 |
| Khmel', IA | 1 |
| Belshaw, PJ; Gehring, AM; Milne, JC; Roy, RS; Walsh, CT | 1 |
| Gundlach, AL; King, PR; Louis, WJ | 1 |
| Aoki, T; Chimoto, T; Hosokawa, S; Sagami, F; Sato, G; Sumigama, S; Tsukidate, K | 1 |
| Golovinsky, E; Jung, G; Stanchev, M; Tabakova, S; Videnov, G | 1 |
| Golovinsky, EV; Jung, G; Stankova, IG; Videnov, GI | 1 |
| Fülöp, F; Lázár, L | 1 |
| Brunmair, B; Fürnsinn, C; Furtmüller, R; Kühnle, HF; Meyer, M; Neschen, S; Nowotny, P; Roden, M; Schneider, B; Waldhäusl, W | 1 |
| Bennett, DJ; Boyd, RE; Codd, EE; Connelly, CD; Gardocki, JF; Hortenstein, JT; Kirifides, AL; Press, JB; Raffa, RB; Rasmussen, CR; Reitz, AB; Reynolds, B | 1 |
| Jenner, S; Rosado, JA; Sage, SO | 1 |
| Donnelly, MA; Zimmer, M | 1 |
| Gil, A; Gutiérrez, LM; Rueda, J; Viniegra, S | 1 |
| Abbotto, A; Bruni, S; Cariati, F; Pagani, GA | 1 |
| Maliwal, BP; Thompson, RB; Zeng, HH | 1 |
| Brown, KK; Glass, CK; Li, AC; Palinski, W; Silvestre, MJ; Willson, TM | 1 |
| Einsiedel, J; Gmeiner, P; Hübner, H; Thomas, C | 1 |
| Hagen, TJ; Hallinan, EA; Savage, MA; Stapelfeld, A; Tsymbalov, S | 1 |
| Balentová, E; Dzurilla, M; Goto, H; Harada, N; Kutschy, P; Monde, K; Suchý, M; Takasugi, M | 1 |
| Leopoldt, D; Rozengurt, E; Yee, HF | 1 |
| Burkart, MD; Keating, TA; Marshall, CG; Walsh, CT | 1 |
| Chatterjee, VK; Nugent, C; O'Rahilly, S; Prins, JB; Savage, D; Wentworth, JM; Whitehead, JP | 1 |
| Boissard, C; Chung, NN; Keller, M; Lemieux, C; Mutter, M; Patiny, L; Schiller, PW | 1 |
| Berger, R; Colletti, SL; deMontigny, P; Fisher, MH; Meinke, PT; Owens, KA; Pivnichny, JV; Schmatz, DM; Shoop, WL; Warmke, LM; Wyvratt, MJ; Zakson-Aiken, M | 1 |
| Caballero, E; Fuentealba, J; Maya, JD; Medarde, M; Morello, A; Núñez-Vergara, LJ; Ortiz, ME; Puebla, P; Repetto, Y; Rodríguez, A; San Feliciano, A; Squella, JA | 1 |
| Inoue, Y; Ishikawa, H; Katsura, Y; Matsumoto, Y; Morinaga, C; Nishino, S; Sakane, K; Takasugi, H | 1 |
| Dalvie, DK; Kalgutkar, AS; Khojasteh-Bakht, SC; O'Donnell, JP; Obach, RS | 1 |
| Crosa, JH; Walsh, CT | 1 |
| Andersen, NH; Bowman, J; Doyle, M; Endsley, S; Erwin, AL; Fong, S; Harris, AL; Harwood, EA; Kline, T; Malanda, A; Mdluli, K; Mendelsohn, B; Raetz, CR; Stover, CK; Witte, PR; Yabannavar, A; Zhu, S | 1 |
| Brosnan, CF; Dumitrescu-Ozimek, L; Feinstein, DL; Galea, E; Gavrilyuk, V; Heneka, MT; Landreth, GE; Pershadsingh, HA; Weinberg, G; Whitacre, CC | 1 |
| Corton, JC; Dohm, GL; Houmard, JA; Kraus, WE; Lang, DB; Li, S; MacLean, PS; Muoio, DM; Way, JM; Winegar, DA | 1 |
| Dakin, LA; Langille, NF; Panek, JS | 1 |
| Bullington, JL; Jackson, PF | 1 |
| Batorsky, R; Bol, D; Bursuker, I; Cai, ZW; Chang, CY; Fairchild, CR; Han, WC; Humphreys, WG; Hunt, JT; Kamath, A; Kellar, KA; Kim, KS; Kimball, SD; Lee, FY; Lu, S; Marathe, P; Misra, RN; Mitt, T; Mulheron, JG; Pavletich, N; Poss, MA; Qian, L; Rawlins, DB; Roongta, U; Sack, JS; Shan, W; Tokarski, JS; Webster, KR; Xiao, HY; Zhu, H | 1 |
| Huang, R; Jin, Z; Li, Z | 1 |
| Abd El Rahman, AH; Abdalla, FA; Ahmed, FA; Atta, SM; Fawzy, NM; Hassaneen, HM; Hegazi, AG | 1 |
| Giordano, ME; Hoffmann, EK; Lionetto, MG; Pedersen, SF; Schettino, T | 1 |
| Fairlie, DP; Glenn, MP; Lucke, AJ; Singh, Y; Stoermer, MJ | 1 |
| Clemetson, KJ; Navdaev, A | 1 |
| Foissner, I; Grolig, F; Obermeyer, G | 1 |
| Eiraku, T; Eto, M; Hirashima, A; Kuwano, E; Shigeta, Y; Taniguchi, E | 1 |
| Jensen, BA; Mann, KK; Ryu, HY; Schlezinger, JJ; Sherr, DH | 1 |
| Kobayashi, J; Mitsui-Saito, M; Nakahata, N; Obara, Y; Ohizumi, Y; Ohkubo, S; Yanagisawa, T | 1 |
| Harvison, PJ; Kennedy, EL; Tchao, R | 1 |
| Chen, YE; Fu, M; Lin, Y; Mao, Z; Zhang, J; Zhu, X | 1 |
| Hartwig, JF; Hooper, MW; Utsunomiya, M | 1 |
| Baker, SF; Brown, J; Davis, B; Hong, G; Khatoon, N | 1 |
| Bekhit, AA; Fahmy, HT | 1 |
| Izeki, T; Shimmen, T; Yokota, E | 1 |
| Downey, CW; Evans, DA; Hubbs, JL | 1 |
| Cai, G; Ma, D; Wei, J; Zou, B | 1 |
| YURA, Y | 2 |
| DAVIS, CS | 1 |
| BALLONOFF, LB; FEINSTEIN, RN; SEAHOLM, JE | 1 |
| COLLIN, RL; PULLMAN, B | 1 |
| Kelly, JW; You, SL | 1 |
| Abdel Aleem, AH; Abdel-Aal, MT; El Ashry, ES; El-Sayed, WA | 1 |
| Jin, Z | 6 |
| Cai, C; Katritzky, AR; Singh, SK; Suzuki, K | 1 |
| Ahmed, SZ; Barbosa, SA; Batorsky, R; Bednarz, MS; Chen, BC; Han, WC; Hunt, JT; Kamath, A; Kellar, KA; Kim, KS; Kimball, SD; Lee, FY; Lu, S; Marathe, P; Misra, RN; Mulheron, JG; Pavletich, NP; Qian, L; Ranadive, SA; Rawlins, DB; Roongta, U; Sack, JS; Shan, W; Tokarski, JS; Webster, KR; Xiao, HY; Zhao, R | 1 |
| Dearden, JC; Filimonov, D; Galaeva, I; Garibova, TL; Geronikaki, AA; Gloriozova, T; Krajneva, V; Lagunin, A; Macaev, FZ; Molodavkin, G; Pogrebnoi, SI; Poroikov, VV; Shepeli, F; Tsitlakidou, M; Vlad, L; Voronina, TA | 1 |
| Blum, E; Buhl, T; Di Padova, FE; Feifel, R; Gram, H; Hiestand, P; Manning, U; Revesz, L; Rucklin, G | 1 |
| Bonnette, F; Gallard, L; Lavastre, O | 1 |
| Chang, M; Chong, S; Kamath, AV; Marathe, PH | 1 |
| Carrieri, A; Crassous, PA; Gentili, F; Ghelfi, F; Giannella, M; Paris, H; Piergentili, A; Pigini, M; Quaglia, W; Vesprini, C | 1 |
| Cress, WD; Freeman, SN; Ma, Y | 1 |
| Kaya, T; Sheu, SH; Vajda, S; Waxman, DJ | 1 |
| Abedini, A; Raleigh, DP | 1 |
| Chen, C; Pontillo, J | 1 |
| Ashton, WT; Dong, H; Doss, GA; He, H; Leiting, B; Lyons, KA; Marsilio, F; Patel, RA; Sisco, RM; Thornberry, NA; Weber, AE; Wu, JK | 1 |
| Blagden, S; de Bono, J | 1 |
| Bai, R; Dettin, LE; Glazer, RI; Kopelovich, L; Kopleovich, L; Kozikowski, AP; Russell, RG; Wei, ZL; Yin, Y | 1 |
| Fairlie, DP; Guthrie, T; Lucke, AJ; Singh, Y; Stoermer, MJ | 1 |
| Ishihara, K; Kondo, R; Sakakura, A | 1 |
| Abbot, EL; Buchan, KW; Hassall, DG; McCormack, JG; Reynet, C; Yeaman, SJ | 1 |
| Adachi, K; Imagawa, H; Kanoh, K; Matsuo, Y; Nishizawa, M; Shizuri, Y | 1 |
| Berliner, MA; Clark, MP; Nag, PP; Stroup, BW; Williams, DR | 1 |
| Fan, MZ; Gu, M; Li, JY; Nan, FJ; Wang, WL; Xing, YC; Yao, DY | 1 |
| Foissner, I; Hörmanseder, K; Obermeyer, G | 1 |
| Ali, MA; Carreon, P; Choy, H; Mukhopadhyay, P; Nandi, A; Saha, D | 1 |
| Fattah, Lel-S; Salama, NN; Taha, EA | 1 |
| Biron, E; Chatterjee, J; Kessler, H | 1 |
| Du, DM; Lu, SF; Xu, J; Zhang, SW | 1 |
| Cress, WD; Ma, Y | 1 |
| Chen, B; Cope, H; Heal, W; Louth, JC; Mutter, R; Thompson, MJ | 1 |
| Bernasek, SL; Tao, F | 1 |
| Cardounel, AJ; Johnson, W; Lu, D; Nadas, J; Villamena, FA; Wang, PG; Zhang, G; Zweier, JL | 1 |
| Ali, MA; Choy, H; Habib, AA; Saha, D | 1 |
| Bertram, A; Maulucci, N; Mohd Nor, SM; New, OM; Pattenden, G | 1 |
| Andersson, S; Bergquist, L; Castro, VM; Danielsson, E; Flyrén, K; Henriksson, M; James, S; Johansson, L; Kaiser, C; Sutin, L; Williams, M | 1 |
| Lai, JR; Walsh, CT; Zhou, Z | 1 |
| Adelman, DC; Bible, K; Heath, EI; Lorusso, PM; Martell, RE | 1 |
| Doucet, H; Roger, J | 1 |
| Fishback, JA; Green, AM; Kaushal, N; Matsumoto, RR; McCurdy, CR; Mésangeau, C; Narayanan, S; Poupaert, JH; Shaikh, J; Viard, E; Xu, YT | 1 |
| Dixon, JE; Dorrestein, PC; Gonzalez, D; Hensler, ME; Lee, SW; Markley, AL; Mitchell, DA; Nizet, V; Wohlrab, A | 1 |
| Comba, P; Gahan, LR; Haberhauer, G; Hanson, GR; Noble, CJ; Seibold, B; van den Brenk, AL | 1 |
| Du, DM; Liu, H; Lu, SF; Xu, J | 1 |
| Baek, SJ; Choi, KW; Choi, S; Han, S; Kang, TY; Kim, SK; Lee, S | 1 |
| Barrett, JF; Burgess, B; Masurekar, P; Onishi, R; Singh, SB; Ushio, M; Zhang, C; Zink, DL | 1 |
| Arkin, MR; Chan, E; Cheeti, S; Choong, IC; Fahr, B; Fan, J; Hoch, U; Lu, Y; Pham, P; Serafimova, I; Stockett, D; Walker, DH | 1 |
| Chan, E; Cheeti, S; Choong, IC; Fahr, B; Fan, J; Hoch, U; Lu, Y; Pham, P; Serafimova, I; Stockett, D; Walker, DH | 1 |
| Bentley, C; Borgognoni, J; Cansfield, AD; Curtin, NJ; Denny, S; Jackson, PS; Kierstan, P; Lockie, AM; Moore, JD; Newell, DR; Scrace, SF; Wang, LZ; Wayne, J; Williamson, DS | 1 |
| Berardi, F; Cantore, M; Colabufo, NA; Contino, M; Inglese, C; Niso, M; Perrone, MG; Perrone, R | 1 |
| Arkin, MR; Conroy, A; Fox, JA; Hawtin, RE; Hoch, U; Stockett, DE; Walker, D | 1 |
| Fischer, R; Kaufmann, DE; Namyslo, JC; Zapol'skii, VA | 1 |
| Habib, AA; Kodym, E; Kodym, R; Reis, AE; Saha, D; Story, MD | 1 |
| Jenkins, ID; Loughlin, WA; Petersson, MJ | 1 |
| Chen, R; Chubb, S; Fox, JA; Gandhi, V; Hawtin, RE; Keating, MJ; Plunkett, W; Wierda, WG | 1 |
| Dalisay, DS; Edison, AS; Molinski, TF; Rogers, EW | 1 |
| Barrish, JC; Belanger, D; Burke, JR; Chen, L; Das, J; Dodd, JH; Dodier, M; Dyckman, AJ; Furch, JA; Gill, P; Gillooly, K; Guo, J; Kempson, J; Langevine, CM; Li, T; Marathe, PH; Marinier, A; Martel, A; McIntyre, KW; McKinnon, M; Moquin, RV; Nirschl, D; Pattoli, MA; Pitts, WJ; Quesnelle, C; Spergel, SH; Van Kirk, K; Wang-Iverson, D; Watterson, SH; Yang, Z | 1 |
| Dixon, JE; Lee, SW; Limm, JD; Markley, AL; Mitchell, DA; Nizet, V; Pence, MA | 1 |
| Ali, MA; Chattopadhyay, A; Ding, LH; Habib, AA; Reis, A; Saha, D; Story, MD | 1 |
| Hachiya, H; Hirano, K; Miura, M; Satoh, T | 1 |
| Chaturvedi, SC; Pancholi, SS; Sharma, RN; Vasu, KK; Xavier, FP | 1 |
| Perandones, BF; Ruiz, J | 1 |
| Chen, B; Thompson, MJ | 1 |
| Boquoi, A; Chen, T; Enders, GH | 1 |
| Iida, K; Nagasawa, K; Shin-Ya, K; Tera, M | 1 |
| Bibb, M; Hesketh, A; Kock, H; Mootien, S | 1 |
| Azimioara, M; Cow, C; Cuc Ngo, C; Epple, R; Gerken, A; Huang, D; Iskandar, M; Karanewsky, DS; Nguyêñ-Trân, VT; Russo, R; Saez, E; Seidel, HM; Spalding, T; Tian, SS; Tuntland, T; Wang, X; Wityak, J; Xie, Y | 1 |
| Blake, AJ; Campbell, IB; Judkins, BD; Lewis, W; Moody, CJ; Shi, B | 1 |
| Farkas, P; Janigová, I; Kronek, J; Kroneková, Z; Luston, J; Paulovicová, E; Paulovicová, L; Petrencíková, N | 1 |
| Castiglia, S; Collino, M; Fantozzi, R; Kapoor, A; Thiemermann, C | 1 |
| Atienzar, F; Célanire, S; Christophe, B; Delannois, F; Delaunoy, C; Delporte, ML; Denonne, F; Durieu, V; Gillard, M; Lallemand, B; Lamberty, Y; Lorent, G; Provins, L; Van Houtvin, N; Vanbellinghen, A; Verbois, V | 1 |
| Chobanian, HR; Dormer, PG; Guo, Y; He, J; Jones, CM; Steves, JE; Strotman, NA | 1 |
| Andersson, PG; Diéguez, M; Mazuela, J; Pàmies, O; Paptchikhine, A | 1 |
| Dinneswara Reddy, G; Mahesh, K; Padmaja, A; Padmavathi, V | 1 |
| Badros, AZ; Chen, R; Chen, T; Coutre, S; Fox, JA; Harvey, RD; Hoch, U; Kegley, P; Mahadocon, K; Plunkett, W; Popplewell, L; Siegel, D; Sinha, R; Tong, WG; Wierda, WG | 1 |
| Barbeau, O; Brigaud, T; Chaume, G; Lesot, P | 1 |
| Chen, R; Cheng, T; Chubb, S; Gandhi, V; Hawtin, RE; Plunkett, W | 1 |
| Abbadie, C; Brochu, RM; Chakravarty, PK; Felix, J; Fisher, MH; Garcia, M; Jochnowitz, N; Kaczorowski, GJ; Klatt, T; Kumar, S; Li, X; Lyons, K; Martin, WJ; McGowan, E; Parsons, WH; Priest, BT; Smith, M; Tyagarajan, S; Warren, V; Williams, B; Wyvratt, MJ; Zhou, B | 1 |
| Bantscheff, M; Drewes, G; Eberhard, D; Frenzel, L; Ghidelli, S; Kruse, U; Maier, SK; Pallasch, CP; Wendtner, CM; Werner, T | 1 |
| Arai, C; Ihara, M; Ikegami-Kawai, M; Ogawa, Y; Yanoshita, R | 1 |
| Chen, R; Chen, Y; Guo, L; Jiang, Y; Plunkett, W; Wierda, WG | 1 |
| Davyt, D; Serra, G | 1 |
| Burnett, AK; Lazenby, M; Pepper, C; Walsby, E | 1 |
| Ji, G; Li, Z; Neugebauer, V | 1 |
| Hirose, T; Inahashi, Y; Ishiyama, A; Iwatsuki, M; Matsumoto, A; Namatame, M; Nishihara-Tsukashima, A; Omura, S; Otoguro, K; Shiomi, K; Sunazuka, T; Takahashi, Y; Yamada, H | 1 |
| Frenzel, E; Niederweis, M; Schmidt, S; Steinhauer, K | 1 |
| Murai, T; Shibahara, F; Yamaguchi, E | 1 |
| Melby, JO; Mitchell, DA; Nard, NJ | 1 |
| Banin, E; Degtyar, E; Elias, S | 1 |
| Comba, P; Dovalil, N; Hanson, GR; Linti, G | 1 |
| Borriss, R; Helaly, SE; Kalyon, B; Nachtigall, J; Scholz, R; Süssmuth, RD; Vater, J | 1 |
| Andrews, KL; Booker, SK; Caenepeel, S; Freeman, DJ; Hughes, PE; Jiang, J; Liao, H; McCarter, J; Mullady, EL; Norman, MH; San Miguel, T; Stec, MM; Subramanian, R; Tamayo, N; Wang, L; Yang, K; Zalameda, LP; Zhang, N | 1 |
| Canivet, J; Itami, K; Komiyama, M; Muto, K; Yamaguchi, J; Yamamoto, T | 1 |
| Almy, J; de Revel, G; Marchand, S | 1 |
| DuBois, RN; Guo, L; Ning, W; Wang, D; Xie, D | 1 |
| Muralikrishna, A; Padmaja, A; Padmavathi, V; Rajasekhar, C | 1 |
| Bumpus, SB; Dunbar, KL; Evans, BS; Kelleher, NL; Lee, J; Melby, JO; Mitchell, DA; Molohon, KJ | 1 |
| Glazer, RI; Kopelovich, L; Upadhyay, G; Yin, Y; Yuan, H | 1 |
| Dupas, G; Hoarau, C; Lassalas, P; Marsais, F; Martin, T; Querolle, O; Théveau, L; Van Hijfte, L; Verrier, C | 1 |
| Hao, M; Ji, M; Li, G; Li, Y; Luo, F; Ren, H; Yang, L; Zhang, S; Zhang, X | 1 |
| Malcolmson, SJ; Walsh, CT; Young, TS | 1 |
| Chen, L; Franzblau, SG; Liu, X; Lu, X; Wan, B; You, Q; Zhou, C | 1 |
| McAlpine, SR; Ramsey, DM; Singh, EK | 1 |
| Boshoff, H; Chang, M; Cho, S; Franzblau, SG; Hwang, CH; Markley, LD; Miller, MJ; Moraski, GC | 1 |
| Dunbar, KL; Melby, JO; Mitchell, DA; Trinh, NQ | 1 |
| Chen, C; Ding, K; Jin, B; Pan, J; Shi, X; Sun, X; Wu, Y; Yeung, SC | 1 |
| Dunbar, KL; Melby, JO; Mitchell, DA | 1 |
| Du, DM; Jia, Y; Yang, W | 1 |
| Raut, RK; Satam, MA; Sekar, N; Tathe, AB | 1 |
| Croft, S; Manta, E; Peña, S; Scarone, L; Serra, G; Stewart, L; Yardley, V | 1 |
| Powner, MW; Szostak, JW; Zheng, SL | 1 |
| Fu, J; Qin, X; Shi, M; Su, X; Zhang, J; Zhao, M | 1 |
| Hider, RC; Kelly, SL; Lamb, DC; Lei, L; Moody, SC; Waterman, MR; Zhao, B | 1 |
| Liu, X; McAlpine, SR; Ramsey, DM; Singh, EK; Tantisantisom, W; Wahyudi, H | 1 |
| Endo, M; Fujii, Y; Matsumoto, K; Ohtake, H; Oka, Y; Sekiguchi, Y; Tamura, Y; Wakahara, S; Yabuuchi, T | 1 |
| Dasgupta, R; Doudican, NA; Mazumder, A; Narayanan, BA; Narayanan, NK; Park, J; Xu, D | 1 |
| Joseph, L; Mei, L; Song, T; Wang, YX; Yadav, VR; Zheng, YM | 1 |
| Berardi, F; Cantore, M; Capparelli, E; Cassano, G; Colabufo, NA; Contino, M; Gasparre, G; Leopoldo, M; Perrone, MG; Perrone, R | 1 |
| Jin, Y; Liu, H; Meng, H; Qian, W; Yang, C; Yang, X; You, L | 1 |
| Bent, AF; Botting, CH; Fuszard, MA; Houssen, WE; Jaspars, M; Koehnke, J; Morawitz, F; Naismith, JH; Shirran, SL; Smellie, IA; Smith, MC | 1 |
| Fechner, G; Hooper, JN; Pham, NB; Quinn, RJ; Tran, TD | 1 |
| Li, C; Li, J; Li, X; Liu, P; Shi, Z; Yin, B | 1 |
| Huang, Y; Liu, N; Shang, F; Xi, L | 1 |
| Dunbar, KL; Mitchell, DA | 1 |
| Campbell-Crawford, M; Frieman, J; Harrison, ZA; Orr, D; Patel, VK; Percy, JM; Tolfrey, A | 1 |
| Choo, H; Choo, IH; Jo, S; Keum, G; Kim, J; Kim, T; Lee, CJ; Lee, J; Lim, EJ; Min, SJ; Moon, B; Nam, G; Park, HR; Park, KD; Yeom, M | 1 |
| Cheng, T; Gao, YD; Ji, Q; Qi, RZ; Xu, J; Yuan, WP; Zhang, LY; Zhang, Y | 1 |
| Alt, S; Brunati, C; Donadio, S; Iorio, M; Maffioli, S; Mazzei, E; Sosio, M; Tocchetti, A | 1 |
| McAlpine, SR; Ramsey, DM; Tantisantisom, W | 1 |
| Bowers, AA; Bradner, JE; Estiu, G; Guerra-Bubb, JM; Paranal, R; Smith, WB; Wiest, O; Williams, RM | 1 |
| Mitchell, DA; Saint-Vincent, PMB; Sharma, A | 1 |
| Murru, S; Nefzi, A | 1 |
| Li, X; Melby, JO; Mitchell, DA | 1 |
| Barba-Marines, A; Castro-Garza, J; Cavazos-Rocha, N; Molina-Torres, CA; Ocampo-Candiani, J; Pucci, MJ; Valles-Guerra, O; Vera-Cabrera, L | 1 |
| Chen, J; Liao, C; Liu, J; Tang, H; Wu, S; Xie, G | 1 |
| Burkhart, BJ; Chekan, JR; Cox, CL; Dunbar, KL; Mitchell, DA; Nair, SK | 1 |
| Fenner, S; Ley, SV; Wilson, ZE | 2 |
| El-Badri, F; Hu, B; Hudson, BM; Kurth, MJ; Phuan, PW; Tantillo, DJ; Verkman, AS; Ye, L | 1 |
| Agadjanian, H; Allen, JR; Aspuria, PJ; Cheon, DJ; Funari, V; Greenberg, D; Karlan, BY; Mizuno, T; Orsulic, S; Spiteri, E; Spurka, L; Taylor-Harding, B; Walsh, C; Wang, Q; Wiedemeyer, WR | 1 |
| Aza-Blanc, P; Matsuzawa, S; Reed, JC; Shi, R; Yanagi, T | 1 |
| Ceckova, M; Cihalova, D; Staud, F | 1 |
| Burkhart, BJ; Cox, CL; Dunbar, KL; Mitchell, DA; Tietz, JI | 1 |
| Han, YX; Liu, H; Mao, LP; Qian, WB; Ye, XJ; You, LS | 1 |
| Chen, H; Ding, HF; Dong, Z; Fang, D; Huang, S; Jing, Q; Lu, Y; Su, SB; Yang, L | 1 |
| Ang, W; Chang, Y; Chen, G; Li, G; Liu, Y; Long, H; Luo, Y; Sang, Z; Tang, J; Wang, Z; Wei, Y; Yang, S; Yang, T; Yang, X; Zhang, J | 1 |
| Bremner, JB; Brkic, Z; Hammer, KA; Keller, PA; Kemker, I; King, AM; Lyras, D; Pyne, SG; Riley, TV; Schröder, DC; Somphol, K; Tague, AJ; Wales, SM | 1 |
| Jin, X; Lei, C; Zhou, JS | 1 |
| Eickhoff, JA; Kobayashi, H; Zakarian, A | 1 |
| Bollens, T; Pekas, A; Put, K; Wäckers, F | 1 |
| Cox, CL; Doroghazi, JR; Mitchell, DA | 1 |
| Anastasina, M; Bamford, DH; De Brabander, JK; Islam, MM; Julkunen, I; Kainov, D; Matikainen, S; Nyman, TA; Poranen, MM; Saelens, X; Šaulienė, I; Söderholm, S; Stenman, J; Tynell, J | 1 |
| Giordano, A; Morales, F | 1 |
| Dan, W; Geng, H; Guo, R; Li, L; Qiao, J; Wei, S; Wu, W; Zhang, J | 1 |
| Chen, HL; Chiang, LL; Hsieh, YH; Lin, CT; Lin, MH; Lin, PY; Lin, YJ; Sheu, SY; Tseng, IJ | 1 |
| Asano, A; Doi, M; Minoura, K; Yamada, T | 1 |
| Abe, M; Goto, T; Hagiwara, M; Hosoya, T; Ikura, T; Ito, N; Kato-Sumida, T; Kii, I; Koike, Y; Nonaka, Y; Okuno, Y; Shibuya, H; Sonamoto, R; Sumida, Y; Yoshida, S | 1 |
| Cai, ZP; Chai, XX; Fu, YJ; Xiong, YZ; Yang, MT; Zhou, Y | 1 |
| Nagy, PI | 1 |
| Balónová, B; Blight, BA; Cinatl, J; Löschmann, N; Michaelis, M; Rothweiler, F; Voges, Y | 1 |
| Agarwal, AK; Garg, A; Sankella, S | 1 |
| Ahmad, A; Ansari, S; Khan, AU; Rauf, A; Subbarao, N; Sudhakar, R; Varshney, H | 1 |
| Bamford, DH; Bugai, A; De Brabander, J; Fu, Y; Gaelings, L; Hukkanen, V; Julkunen, I; Kainov, DE; Kuisma, M; Le Goffic, R; Lorey, MB; Marjomäki, V; Matikainen, S; Miller, MS; Nandania, J; Nyman, TA; Paavilainen, H; Saelens, X; Schepens, B; Söderholm, S; Tynell, J; Vande Ginste, L; Velagapudi, V | 1 |
| Abhale, YK; Bhansali, S; Chavan, AP; Deshmukh, KK; Mhaske, PC; Nawale, L; Sarkar, D; Sasane, AV; Shekh, SH | 1 |
| Chen, X; Ge, Y; He, X; Lei, W; Ma, Y; Mou, X; Ru, G; Wang, S; Wang, Y; Wei, B | 1 |
| Anderson, RF; Blaser, A; Chatelain, E; Denny, WA; Franzblau, SG; Launay, D; Ma, Z; Maes, L; Palmer, BD; Shinde, SS; Thompson, AM; Wan, B; Wang, Y | 1 |
| Arrechea, PL; Buchwald, SL; Olsen, EPK | 1 |
| Chang, BCH; Cowley, KJ; Gasser, RB; Jabbar, A; Jiao, Y; Koehler, AV; Laleu, B; Palmer, MJ; Preston, S; Simpson, KJ; Stroehlein, AJ; Wells, TNC | 1 |
| Caballero, J; Fuentes, E; Muñoz-Gutiérrez, C; Palomo, I; Sepúlveda, C | 1 |
| Adnan-Awad, S; Aittokallio, T; Anders, S; Andersson, EI; Bellanger, D; Brümmendorf, TH; Crispatzu, G; Cuesta-Mateos, C; Ding, W; Dufva, O; Eldfors, S; Ellonen, P; Faber, E; He, L; Herling, M; Huber, W; Kallioniemi, O; Khan, S; Koschmieder, S; Kytölä, S; Lagström, S; Lauhio, A; Mpindi, JP; Mustjoki, S; Oleś, M; Pemovska, T; Pietarinen, P; Pützer, S; Savolainen, ER; Schrader, A; Sellner, L; Siitonen, T; Stern, MH; Tang, J; Tomska, K; Wennerberg, K; Yadav, B; Zenz, T; Zhang, H | 1 |
| Boukhali, M; Bradner, JE; Doctor, ZM; Erb, MA; Fischer, ES; Gray, NS; Green, JL; Haas, W; Jiang, B; Kwiatkowski, N; Liang, Y; Nomanbhoy, T; Olson, CM; Winter, GE; Young, RA; Zhang, T; Zhang, Z | 1 |
| Hu, A; Huang, L; Huang, M; Liu, A; Liu, M; Liu, W; Pei, H; Yan, Z; Yi, H | 1 |
| Ali, A; Ansari, A; Asif, M; Owais, M; Rauf, MA | 1 |
| Connelly, MC; Guy, RK; Hobrath, JV; Mathew, B; Reynolds, RC | 1 |
| Bartoloni, FH; Coutinho Neto, MD; de Carvalho, F; Homem-de-Mello, P | 1 |
| Jeong, JH; Jo, HR; Kang, MA; Kim, MH; Kim, W; Shin, YJ | 1 |
| Brors, B; Huber, W; Hüllein, J; Kurilov, R; Lee, KS; Lukas, M; Oleś, M; Sellner, L; Tomska, K; Wagner, L; Walther, T; Zenz, T | 1 |
| Bellavance, G; Buchman, M; Krieger, J; Nicolaou, KC; Pulukuri, KK; Subramanian, P | 1 |
| Bass, J; Brust, R; Ge, Q; Hughes, TS; Kamenekca, TM; Kojetin, DJ; Lin, H; Mosure, SA; Munoz-Tello, P; Shang, J; Tang, M | 1 |
| Dhakal, D; Mishra, R; Rayamajhi, V; Sohng, JK | 1 |
| Borduas-Dedekind, N; Lau, K; Manfrin, A; McNeill, K | 1 |
| Ermert, P; Luther, A; Obrecht, D; Zbinden, P | 1 |
| Blanco, MJ | 1 |
| Guo, J; Hao, Y; Ji, X; Li, Y; Liu, Y; Ma, D; Ni, J; Pang, H; Wang, Q; Wang, Z | 1 |
| Goto, Y; Suga, H | 1 |
| Liu, S; Pan, J; Ye, Q; Zhang, J | 1 |
| Khan, AA; Rahim, F; Rehman, AU; Shah, SAA; Taha, M; Tariq, S; Uddin, I; Uddin, N; Ullah, H; Wadood, A; Zafar, S; Zaman, K | 1 |
| Hu, L; Li, Y; Ruan, C; Wang, Q; Wang, S; Ye, M; Zhang, X | 1 |
| Meng, G; Nolan, SP; Szostak, M; Zhao, Q | 1 |
| Balraju, V; Jogula, S; Krishna, VS; Meda, N; Sriram, D | 1 |
| Anh, DT; Anh, VT; Dung, DTM; Hai, PT; Han, SB; Hue, VTM; Huong, LT; Jun, HW; Kang, JS; Kwon, JH; Nam, NH; Park, EJ | 1 |
| da Cruz Dantas, L; da Silva Filho, AJ; de Santana, OL | 1 |
| Ahmed, B; Keshari, M; Khalilullah, H; Khan, RA; Yusuf, M | 1 |
| Rajan, R; Schepmann, D; Schreiber, JA; Seebohm, G; Wünsch, B | 1 |
| Cragg, PJ; Padnya, PL; Shurpik, DN; Stoikov, II | 1 |
| Astakhova, AA; Chistyakov, DV; Goriainov, SV; Sergeeva, MG | 1 |
| Kumar, G; Singh, NP | 1 |
| Cardona-Trujillo, MC; Garzón-Castaño, SC; Guerrero-Pepinosa, NY; Sepúlveda-Arias, JC; Veloza, LA | 1 |
| Ábrányi-Balogh, P; Bajusz, D; Ferenczy, GG; Gobec, M; Gobec, S; Imre, T; Keserű, GM; Knez, D; Kollár, L; Petri, L; Proj, M; Sosič, I; Szilágyi, B | 1 |
| Kaji, C; Kikuchi, C; Kubota-Ishida, N; Matsuhira, T; Tabata, Y | 1 |
| Hameed, A; Iqbal, J; Jalil, S; Mirza, AZ; Naz, A; Osra, FA; Qazi, SU; Shah, SAA | 1 |
| Chen, L; Fang, D; Song, Y; Wang, C; Xie, S; Yang, H; Zeng, H; Zhao, Z | 1 |
| Chen, X; Ding, W; Jiang, L; Liu, A; Liu, J; Shi, X; Wen, C; Zhang, H; Zhou, H | 1 |
| Collisi, W; Lizzadro, L; Schinzer, D; Spieß, O; Stadler, M | 1 |
| Barić, D; Burčul, F; Juričević, I; Lasić, Z; Marinić, Ž; Mlakić, M; Odak, I; Šagud, I; Škorić, I; Đurčević, E | 1 |
30 review(s) available for thiazoles and oxazoles
| Article | Year |
|---|---|
Mitigating heterocycle metabolism in drug discovery.
Topics: Animals; Biotransformation; Databases, Factual; Drug Discovery; Drug Interactions; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Pharmaceutical Preparations; Rats | 2012 |
Thiazoles, Their Benzofused Systems, and Thiazolidinone Derivatives: Versatile and Promising Tools to Combat Antibiotic Resistance.
Topics: Animals; Anti-Bacterial Agents; Benzene; Biofilms; Drug Resistance, Microbial; Humans; Microbial Sensitivity Tests; Structure-Activity Relationship; Thiazoles; Thiazolidines | 2020 |
[Intramolecular cyclization of nitrogen mustard compounds].
Topics: Azepines; Chemical Phenomena; Chemistry; Cyclization; Imidazoles; Nitrogen Mustard Compounds; Oxazines; Oxazoles; Purines; Pyrimidines; Thiadiazines; Thiazoles; Triazines | 1975 |
Muscarine, oxazole, thiazole, imidazole and peptide alkaloids and other miscellaneous alkaloids.
Topics: Alkaloids; Animals; Fungi; Imidazoles; Muscarine; Oxazoles; Peptides; Plants; Thiazoles | 1992 |
Muscarine, oxazole, imidazole, thiazole, and peptide alkaloids, and other miscellaneous alkaloids.
Topics: Animals; Humans; Imidazoles; Muscarine; Oxazoles; Peptides; Thiazoles | 1995 |
Muscarine, oxazole, imidazole, thiazole, and peptide alkaloids and other miscellaneous alkaloids.
Topics: Alkaloids; Animals; Antineoplastic Agents; Imidazoles; Muscarine; Oxazoles; Peptides; Thiazoles | 1993 |
[Microcins--peptide antibiotics of enterobacteria: genetic control of the synthesis, structure, and mechanism of action].
Topics: Anti-Bacterial Agents; Bacteriocins; Enterobacteriaceae; Oxazoles; Peptides; Plasmids; Protein Conformation; Protein Processing, Post-Translational; Thiazoles | 1999 |
Thiazole and oxazole peptides: biosynthesis and molecular machinery.
Topics: Amino Acid Sequence; Animals; Cyclization; Humans; Molecular Sequence Data; Oxazoles; Peptides; Protein Conformation; Protein Processing, Post-Translational; Thiazoles | 1999 |
Amaryllidaceae, Sceletium, imidazole, oxazole, thiazole, peptide and miscellaneous alkaloids.
Topics: Alkaloids; Animals; Biological Factors; Imidazoles; Molecular Structure; Oxazoles; Peptides; Plants; Thiazoles | 2001 |
Biotransformation reactions of five-membered aromatic heterocyclic rings.
Topics: Animals; Cytochrome P-450 Enzyme System; Furans; Heterocyclic Compounds, 4 or More Rings; Humans; Imidazoles; Indoles; Isoxazoles; Models, Chemical; Molecular Structure; Oxadiazoles; Oxazoles; Pyrazoles; Pyrroles; Tetrazoles; Thiadiazoles; Thiazoles; Thiophenes; Triazoles; Xenobiotics | 2002 |
Genetics and assembly line enzymology of siderophore biosynthesis in bacteria.
Topics: Amino Acid Sequence; Bacteria; Catechols; Enterobactin; Genes, Bacterial; Molecular Sequence Data; Molecular Structure; Oxazoles; Peptides; Phenols; Sequence Homology, Amino Acid; Siderophores; Thiazoles | 2002 |
Pyridinylimidazole based p38 MAP kinase inhibitors.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Drug Design; Enzyme Inhibitors; Humans; Imidazoles; Indoles; Mitogen-Activated Protein Kinases; Oxazoles; p38 Mitogen-Activated Protein Kinases; Pyridines; Structure-Activity Relationship; Thiazoles; Tumor Cells, Cultured | 2002 |
Muscarine, imidazole, oxazole, thiazole, Amaryllidaceae and Sceletium alkaloids.
Topics: Alkaloids; Amino Acid Sequence; Biological Factors; Catalysis; Imidazoles; Molecular Structure; Muscarine; Oxazoles; Plants, Medicinal; Stereoisomerism; Thiazoles | 2002 |
Muscarine, imidazole, oxazole, and thiazole alkaloids.
Topics: Alkaloids; Biological Factors; Imidazoles; Molecular Structure; Muscarine; Oxazoles; Structure-Activity Relationship; Thiazoles | 2003 |
Parallel and combinatorial approaches for synthesis of ligands.
Topics: Combinatorial Chemistry Techniques; Drug Design; Ligands; Models, Chemical; Oxazoles; Peptides; Pyridines; Thiazoles | 2004 |
Muscarine, oxazole, imidazole, thiazole, and peptide alkaloids, and other miscellaneous alkaloids.
Topics: Alkaloids; Imidazoles; Molecular Structure; Muscarine; Oxazoles; Peptides; Plants; Streptomyces; Thiazoles | 1994 |
Muscarine, imidazole, oxazole and thiazole alkaloids.
Topics: Alkaloids; Biological Factors; Imidazoles; Molecular Structure; Muscarine; Oxazoles; Structure-Activity Relationship; Thiazoles | 2005 |
Drugging cell cycle kinases in cancer therapy.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Binding Sites; Cyclin-Dependent Kinases; Flavonoids; Humans; Neoplasms; Oxazoles; Piperidines; Protein Kinase Inhibitors; Purines; Roscovitine; Staurosporine; Sulfonamides; Thiazoles | 2005 |
Imidazole, oxazole and thiazole alkaloids.
Topics: Alkaloids; Biological Factors; Imidazoles; Molecular Structure; Oxazoles; Thiazoles | 2006 |
Muscarine, imidazole, oxazole and thiazole alkaloids.
Topics: Alkaloids; Biological Factors; Imidazoles; Molecular Structure; Muscarine; Oxazoles; Structure-Activity Relationship; Thiazoles | 2009 |
Thiazole and oxazole alkaloids: isolation and synthesis.
Topics: Alkaloids; Animals; Biological Products; Drug Design; Drug Discovery; Humans; Oxazoles; Thiazoles | 2010 |
Thiazole/oxazole-modified microcins: complex natural products from ribosomal templates.
Topics: Bacteria; Bacteriocins; Biological Products; Oxazoles; Protein Processing, Post-Translational; Ribosomes; Thiazoles | 2011 |
Muscarine, imidazole, oxazole, and thiazole alkaloids.
Topics: Alkaloids; Biological Factors; Imidazoles; Molecular Structure; Muscarine; Oxazoles; Structure-Activity Relationship; Thiazoles | 2011 |
Muscarine, imidaozle, oxazole and thiazole alkaloids.
Topics: Alkaloids; Biological Products; Imidazoles; Molecular Structure; Muscarine; Oxazoles; Thiazoles | 2013 |
Overview of CDK9 as a target in cancer research.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Cell Cycle; Cyclic N-Oxides; Cyclin-Dependent Kinase 9; Flavonoids; Humans; Indolizines; Molecular Targeted Therapy; Neoplasms; Oxazoles; Piperidines; Protein Kinase Inhibitors; Purines; Pyrazoles; Pyridinium Compounds; Roscovitine; Thiazoles; Urea | 2016 |
Bioactive molecules from Nocardia: diversity, bioactivities and biosynthesis.
Topics: Aminoglycosides; Biological Products; Genetic Variation; Gram-Positive Bacteria; Lactams; Lactones; Nocardia; Oxazoles; Peptides, Cyclic; Thiazoles | 2019 |
Frontier Between Cyclic Peptides and Macrocycles.
Topics: Biological Products; Cyclization; Depsipeptides; Humans; Lactones; Macrocyclic Compounds; Oxazoles; Peptide Library; Peptides, Cyclic; Permeability; Protein Conformation; Spiro Compounds; Streptogramins; Thiazoles | 2019 |
N-Heterocyclic Carbene Complexes in C-H Activation Reactions.
Topics: Chemistry Techniques, Synthetic; Heterocyclic Compounds; Imidazoles; Methane; Organometallic Compounds; Oxazoles; Palladium; Thiazoles | 2020 |
Antimicrobial Activity of Calixarenes and Related Macrocycles.
Topics: Amino Acid Motifs; Animals; Anti-Infective Agents; Biofilms; Calixarenes; Drug Delivery Systems; Glycosylation; Humans; Lectins; Metals; Nanoparticles; Oxazoles; Phenylalanine; Prodrugs; Solubility; Sulfonamides; Thiadiazoles; Thiazoles; Vancomycin; Water | 2020 |
Antiproliferative activity of thiazole and oxazole derivatives: A systematic review of in vitro and in vivo studies.
Topics: A549 Cells; Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Antifungal Agents; Cell Proliferation; HeLa Cells; Hep G2 Cells; Humans; Oxazoles; Structure-Activity Relationship; Thiazoles | 2021 |
4 trial(s) available for thiazoles and oxazoles
| Article | Year |
|---|---|
[Experiences with Atricana in the treatment of trichomoniasis].
Topics: Antiprotozoal Agents; Antitrichomonal Agents; Female; Humans; Male; Metronidazole; Oxazoles; Thiazoles; Trichomonas Infections | 1969 |
A phase 1 study of SNS-032 (formerly BMS-387032), a potent inhibitor of cyclin-dependent kinases 2, 7 and 9 administered as a single oral dose and weekly infusion in patients with metastatic refractory solid tumors.
Topics: Administration, Oral; Adult; Aged; Anemia; Angiogenesis Inhibitors; Area Under Curve; Biological Availability; CDC2-CDC28 Kinases; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasm Metastasis; Neoplasms; Neutropenia; Oxazoles; Radiotherapy, Adjuvant; Thiazoles; Time Factors; Treatment Outcome | 2008 |
SNS-032 is a potent and selective CDK 2, 7 and 9 inhibitor that drives target modulation in patient samples.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cyclin-Dependent Kinases; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Multiple Myeloma; Oxazoles; Protein Kinase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles | 2009 |
Phase I and pharmacologic study of SNS-032, a potent and selective Cdk2, 7, and 9 inhibitor, in patients with advanced chronic lymphocytic leukemia and multiple myeloma.
Topics: Aged; Aged, 80 and over; Biomarkers, Tumor; Cohort Studies; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 9; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Maximum Tolerated Dose; Middle Aged; Multiple Myeloma; Oxazoles; Survival Rate; Thiazoles; Tissue Distribution; Treatment Outcome | 2010 |
317 other study(ies) available for thiazoles and oxazoles
| Article | Year |
|---|---|
Synthesis of some 2'-(3-oxopregn-4-en-20-yl)oxazolidines and -thiazolidines.
Topics: Drug Evaluation, Preclinical; Oxazoles; Thiazoles | 1979 |
Species-specific effects on the optical signals of voltage-sensitive dyes.
Topics: Action Potentials; Animals; Coloring Agents; Electric Stimulation; Electrophysiology; Membrane Potentials; Neurons; Optics and Photonics; Oxazoles; Oxazolone; Rhodanine; Species Specificity; Thiazoles | 1979 |
Membrane-potential-sensitive dyes for optical monitoring of activity in Aplysia neurons.
Topics: Action Potentials; Animals; Aplysia; Circadian Rhythm; Coloring Agents; Membrane Potentials; Neurons; Optic Nerve; Oxazoles; Rhodanine; Thiazoles | 1978 |
Acetylene compounds of potential pharmacological value. XXXVI. N-(4-tert-Amino-2-butynyl)-substituted 2(3H)-thiazolones and 2(3H)-oxazolones.
Topics: Animals; Chemical Phenomena; Chemistry; Drug Evaluation, Preclinical; Mice; Mydriatics; Oxazoles; Oxotremorine; Receptors, Cholinergic; Thiazoles | 1978 |
Influence of steric factors on the interaction of isomeric phenyloxazoles and phenylthiazoles with microsomal oxidation.
Topics: Animals; In Vitro Techniques; Isomerism; Larva; Microsomes; Microsomes, Liver; Moths; Oxazoles; Oxidation-Reduction; Rats; Thiazoles | 1978 |
Novel pyrazolo, isoxazolo, and thiazolo steroidal systems and model analogs containing dimethyoxylaryl (or dihydroxylaryl) groups and derivatives. Synthesis, spectral properties, and biological activity.
Topics: Bacillus subtilis; Cells, Cultured; Depression, Chemical; Humans; Isoxazoles; Magnetic Resonance Spectroscopy; Oxazoles; Pseudomonas fluorescens; Pyrazoles; Spectrophotometry, Infrared; Staphylococcus aureus; Steroids, Heterocyclic; Thiazoles | 1976 |
A profile of the gastrointestinal toxicity of aspirin, indomethacin, oxaprozin, phenylbutazone, and fentiazac in arthritic and Lewis normal rats.
Topics: Acetates; Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Aspirin; Body Weight; Gastrointestinal Diseases; Indomethacin; Intestine, Small; Male; Oxazoles; Phenylbutazone; Propionates; Rats; Stomach; Thiazoles; Time Factors | 1977 |
[Heterocyclic o-amino-phosphonic esters (author's transl)].
Topics: Heterocyclic Compounds; Organophosphonates; Oxazoles; Pyrimidines; Thiazoles; Thiophenes | 1975 |
Synthesis of heteroaromatic analogues of prostaglandins.
Topics: Magnetic Resonance Spectroscopy; Mass Spectrometry; Oxazoles; Prostaglandins; Spectrophotometry, Infrared; Thiazoles | 1975 |
Stable fluorescent complexes of double-stranded DNA with bis-intercalating asymmetric cyanine dyes: properties and applications.
Topics: Benzoxazoles; DNA; Electrophoresis, Agar Gel; Ethidium; Fluorescent Dyes; Intercalating Agents; Magnetic Resonance Spectroscopy; Models, Molecular; Oxazoles; Quinolinium Compounds; Restriction Mapping; Thiazoles | 1992 |
Synthesis and antibacterial activity of thiazolo-, oxazolo-, and imidazolo[3,2-a][1,8]naphthyridinecarboxylic acids.
Topics: Anti-Bacterial Agents; Escherichia coli; Gram-Negative Bacteria; Gram-Positive Bacteria; Imidazoles; Indicators and Reagents; Microbial Sensitivity Tests; Molecular Structure; Naphthyridines; Oxazoles; Structure-Activity Relationship; Thiazoles; Topoisomerase II Inhibitors | 1990 |
Ibotenic acid stimulates D-[3H]aspartate release from cultured cerebellar granule cells.
Topics: Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Cerebellum; Ibotenic Acid; Oxazoles; Phosphoserine; Rats; Receptors, Amino Acid; Receptors, Cell Surface; Riluzole; Thiazoles | 1989 |
Synthesis and biological evaluation of 1-(1,2-benzisothiazol-3-yl)- and (1,2-benzisoxazol-3-yl)piperazine derivatives as potential antipsychotic agents.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Binding, Competitive; Catalepsy; Cerebral Cortex; Corpus Striatum; Isoxazoles; Male; Models, Molecular; Norepinephrine; Oxazoles; Physostigmine; Piperazines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Serotonin; Sleep; Spiro Compounds; Stereotyped Behavior; Structure-Activity Relationship; Thiazoles | 1986 |
Comparative effects of famotidine and cimetidine on trimethadione metabolism in the rat.
Topics: Animals; Cimetidine; Famotidine; Histamine H2 Antagonists; Kinetics; Male; Microsomes, Liver; Mixed Function Oxygenases; Oxazoles; Rats; Thiazoles; Trimethadione | 1986 |
Voltage-sensitive dyes measure potential changes in axons and glia of the frog optic nerve.
Topics: Animals; Axons; Benzoxazoles; Electric Stimulation; Electrophysiology; Microelectrodes; Neuroglia; Optic Nerve; Oxazoles; Oxazolone; Rana pipiens; Rhodanine; Thiazoles; Thiazolidines | 1986 |
[Toxicology of selected biocides].
Topics: Anti-Infective Agents, Local; Antifungal Agents; Biguanides; Chlorophenols; Cosmetics; Dichlorophen; Disinfectants; Hydrogen Peroxide; Oxazoles; Pharmaceutic Aids; Preservatives, Pharmaceutical; Thiazoles | 1987 |
Benzo-2,1,5-oxadiazoles--a novel class of heterocyclic monoamine oxidase inhibitors.
Topics: Animals; Carbon Radioisotopes; In Vitro Techniques; Kinetics; Male; Mitochondria, Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxadiazoles; Oxazoles; Rats; Structure-Activity Relationship; Thiadiazoles; Thiazoles; Tryptamines | 1974 |
Novel tricyclic systems. Oxazole, thiazole, and imidazole analogs of the amitriptyline type.
Topics: Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Benzocycloheptenes; Body Temperature; Central Nervous System; Imidazoles; Lethal Dose 50; Mice; Motor Activity; Oxazoles; Sleep; Thiazoles | 1974 |
Ring opening of thiamine analogs. The role of ring opening in physiological function.
Topics: Carboxy-Lyases; Drug Stability; Half-Life; Hydrogen-Ion Concentration; Imidazoles; Kinetics; Magnetic Resonance Spectroscopy; Molecular Conformation; Oxazoles; Structure-Activity Relationship; Sulfonic Acids; Thiamine; Thiazoles; Time Factors | 1974 |
3,5-Dialkyl-4-(phthalimidomethyl)isoxazoles, pyrazoles, and isothiazoles. Novel antiandrogens.
Topics: Androgen Antagonists; Animals; Castration; Imides; Male; Mass Spectrometry; Organ Size; Oxazoles; Phthalic Acids; Prostate; Pyrazoles; Rats; Seminal Vesicles; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Testosterone; Thiazoles | 1973 |
Increase of brain levels of tryptophan induced by inhibition of dopamine beta-hydroxylase (EC 1.14.2.1).
Topics: Animals; Brain; Cresols; Disulfides; Dopamine beta-Hydroxylase; Hydroxyindoleacetic Acid; Imidazoles; Kinetics; Male; Norepinephrine; Oxazoles; Phenylthiourea; Rats; Serotonin; Thiazoles; Tryptophan | 1973 |
Synthesis of delta-2-oxazolines by reaction of epoxides with delta-2-thiazolines.
Topics: Chemistry, Organic; Ethers, Cyclic; Organic Chemistry Phenomena; Oxazoles; Thiazoles | 1966 |
[3-Aminoalkoxy-1,2-benzisothiazoles: pharmacological properties of quaternary ammonium compounds].
Topics: Animals; Anura; Blood Pressure; Cats; Dogs; Heart; Muscles; Nictitating Membrane; Oxazoles; Quaternary Ammonium Compounds; Respiration; Thiazoles | 1972 |
[Biological properties of 1,2-benzisothiazoles: chemosterilant activity of aziridine derivatives].
Topics: Azirines; Chemosterilants; Houseflies; Insect Control; Oxazoles; Thiazoles | 1972 |
[Steroids 28. Preparation of steroid hormone analogs from 2,3 beta-imino-5 alpha-androstan-17 beta-ol and 2 beta-amino-3 alpha-chlor-5 alpha-androstan-17 beta-ol].
Topics: Amino Alcohols; Androstanes; Chemical Phenomena; Chemistry; Imines; Methods; Oxazoles; Thiazoles | 1971 |
Anxiolytic sedatives. 1. Synthesis and pharmacology of benzo[6,7]-1,4-diazepino[5,4-b]oxazole derivatives and analogs.
Topics: Animals; Bemegride; Dibenzazepines; Hypnotics and Sedatives; Lethal Dose 50; Male; Methods; Mice; Oxazoles; Stereoisomerism; Thiazoles | 1971 |
Synthesis of terminal N-thiobenzoyl peptides by use of 4-substituted 2-phenylthiazol-5(4H)-ones as acylating agents for amino-acids and peptides. Optically-active 4-substituted 2-phenylthiazol-5(4H)-ones.
Topics: Amino Acid Sequence; Ketones; Oxazoles; Peptides; Thiazoles | 1971 |
[Biological properties of 1,2-benzisothiazole compounds. On some pharmacological characteristics of benzisoxazolone and of benzisothiazolone].
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Body Temperature; Inflammation; Mice; Oxazoles; Phenylbutazone; Rats; Salicylamides; Thiazoles | 1971 |
Fundamental studies on models for thiamine. Generation of ylides of oxazolium, imidazolium, and thiazolium ions by decarboxylation. Applications to the structure of the thiamine ylide.
Topics: Chemical Phenomena; Chemistry; Cyclization; Decarboxylation; Imidazoles; Models, Chemical; Oxazoles; Structure-Activity Relationship; Thiamine; Thiazoles | 1971 |
[On glucosides from imidazol-, oxazol- and thiazolethiones-(2). 30. On the "glycosides from heterocyclic" compounds].
Topics: Glycosides; Imidazoles; Oxazoles; Sulfur; Thiazoles | 1968 |
Diaryloxazole and diarylthiazolealkanoic acids: two novel series of non-steroidal anti-inflammatory agents.
Topics: Aldehydes; Animals; Anti-Inflammatory Agents; Aspirin; Biological Assay; Carrageenan; Edema; Gastric Mucosa; Gastrointestinal Hemorrhage; Hot Temperature; Humans; Indomethacin; Oxazoles; Phenylbutazone; Protein Denaturation; Rats; Serum Albumin; Thiazoles | 1968 |
Conformational aspects of polypeptide structure. 31. Helical poly[(S)-thiazolidine-4-carboxylic acid] and poly[(S)-oxazolidine-4-carboxylic acid]. Theoretical results.
Topics: Models, Chemical; Oxazoles; Peptides; Polymers; Thiazoles | 1970 |
[Synthesis of therapeutic 1,3,4-thiadiazoles by acid catalysed cyclization of N1-acyl-N4-arylthiosemicarbazides of cinnamic acid].
Topics: Analgesics; Catalysis; Chemistry Techniques, Analytical; Chemistry, Pharmaceutical; Cinnamates; Infrared Rays; Oxazoles; Semicarbazides; Spectrum Analysis; Thiazoles | 1970 |
Compounds related to clomethiazole. 3. 4,5-dialkyl-substituted thiazoles, oxazoles and imidazoles.
Topics: Imidazoles; Oxazoles; Thiazoles | 1970 |
Compounds related to clomethiazole. IV. 4-Methylthiazoles and oxazoles with polar side-chains and some other analogues of clomethiazole.
Topics: Animals; Chemical Phenomena; Chemistry; Chlormethiazole; Mice; Oxazoles; Thiazoles | 1971 |
Compounds related to clomethiazole. V. 4-(Alkyl or aryl) thiazoles and oxazoles with various substituents in the 2- and 5-positions.
Topics: Chemical Phenomena; Chemistry; Chlormethiazole; Oxazoles; Thiazoles | 1971 |
Pteridines. 8. Some 2,4,7-triamino-6-heteroarylpteridines.
Topics: Chromatography, Paper; Furans; Hydrogen-Ion Concentration; Imidazoles; Oxazoles; Pteridines; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Spectrum Analysis; Thiazoles; Thiophenes; Triazoles; Ultraviolet Rays | 1968 |
[Studies on heterocyclic compounds. 8. Synthesis of methyl 2-amino-5-methoxycarbonyl-4-thiazolylacetate and methyl 2-amino-5-methoxycarbonyl-4-oxazolylacetate derivatives].
Topics: Acetates; Oxazoles; Thiazoles | 1968 |
Steroids 23. Synthesis fo some ring A-fused heterocyclic steroids.
Topics: Anabolic Agents; Chemical Phenomena; Chemistry; Heterocyclic Compounds; Imidazoles; Oxazoles; Pyrazoles; Thiazoles; Triazoles | 1965 |
Compounds related to clomethiazole. I. Oxazole and pyridine isosteres of clomethiazole.
Topics: Anticonvulsants; Chemical Phenomena; Chemistry; Chemistry, Pharmaceutical; Hypnotics and Sedatives; Oxazoles; Pyridines; Thiazoles | 1966 |
alpha 1-adrenoceptor blockade by alpha 2-adrenoceptor agonists in the isolated perfused hindquarter of rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Azepines; Clonidine; In Vitro Techniques; Male; Methoxamine; Oxazoles; Perfusion; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Thiazoles; Vasoconstriction | 1981 |
The effect of selective alpha 1- and alpha 2-adrenoceptor stimulation on intraocular pressure in the conscious rabbit.
Topics: Adrenergic alpha-Agonists; Animals; Azepines; Female; Intraocular Pressure; Male; Oxazoles; Phenylephrine; Rabbits; Thiazoles; Yohimbine | 1981 |
Binding of an imidazolidine (clonidine), an oxazoloazepin (B-HT 933) and a thiazoloazepin (B-HT 920) to rat brain alpha-adrenoceptors and relation to cardiovascular effects.
Topics: Animals; Azepines; Binding Sites; Binding, Competitive; Blood Pressure; Brain; Clonidine; Heart Rate; Kinetics; Male; Oxazoles; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Thiazoles | 1980 |
Central cardiovascular alpha-adrenoceptors. Relation to peripheral receptors.
Topics: Animals; Azepines; Blood Pressure; Cardiovascular System; Clonidine; Dose-Response Relationship, Drug; Heart Rate; Male; Methoxamine; Norepinephrine; Oxazoles; Perfusion; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Thiazoles; Vagotomy | 1980 |
Dichroic behavior of the absorbance signals from dyes NK2367 and WW375 in skeletal muscle fibers.
Topics: Absorption; Animals; Membranes; Models, Biological; Muscles; Oxazoles; Oxazolone; Potentiometry; Rana catesbeiana; Rhodanine; Spectrum Analysis; Thiazoles | 1984 |
[Nonsteroidal anti-inflammatory agents. 17. 4,5-Bis-(4-methoxyphenyl)-2-arylthioazoles with antiphlogistic activity].
Topics: Animals; Anti-Inflammatory Agents; Imidazoles; Oxazoles; Rats; Thiazoles | 1983 |
Mutagenicity of two non-formaldehyde-forming antimicrobial agents.
Topics: Animals; Anti-Infective Agents, Local; In Vitro Techniques; Mutagens; Oxazoles; Rats; Thiazoles | 1983 |
[Antitumor effect of compounds synthesized in the Division of Synthetic Chemistry (V) (author's transl)].
Topics: Animals; Antineoplastic Agents; Drug Evaluation, Preclinical; Leukemia L1210; Mice; Nitroso Compounds; Nitrosourea Compounds; Oxazoles; Rats; Thiadiazoles; Thiazoles | 1981 |
Studies on cerebral protective agents. VII. Synthesis of novel 4-arylazole derivatives with anti-anoxic activity.
Topics: Animals; Arachidonic Acid; Brain Edema; Chemical Phenomena; Chemistry, Physical; Hypoxia, Brain; Imidazoles; Lethal Dose 50; Lipid Peroxidation; Male; Mice; Mice, Inbred ICR; Oxazoles; Structure-Activity Relationship; Thiazoles | 1995 |
Application of pharmacokinetic studies to a novel antidepressant, E2011.
Topics: Animals; Antidepressive Agents; Benzothiazoles; Biotransformation; Chromatography, High Pressure Liquid; Dogs; In Vitro Techniques; Male; Microsomes, Liver; Mixed Function Oxygenases; Monoamine Oxidase Inhibitors; Oxazoles; Oxazolidinones; Rats; Rats, Sprague-Dawley; Stereoisomerism; Thiazoles | 1994 |
[[[(Thienylcarbonyl)alkyl]oxy]phenyl]- and [[[(pyrrylcarbonyl)alkyl]oxy]phenyl]oxazoline derivatives with potent and selective antihuman rhinovirus activity.
Topics: Antiviral Agents; Cytopathogenic Effect, Viral; HeLa Cells; Humans; Oxazoles; Rhinovirus; Structure-Activity Relationship; Tetrazolium Salts; Thiazoles | 1995 |
Microbial metabolites with tipA promoter inducing activity. II. Geninthiocin, a novel thiopeptide produced by Streptomyces sp. DD84.
Topics: Anti-Bacterial Agents; Bacterial Proteins; Chemical Phenomena; Chemistry, Physical; Magnetic Resonance Spectroscopy; Molecular Structure; Oxazoles; Peptides; Peptides, Cyclic; Promoter Regions, Genetic; Streptomyces; Thiazoles; Trans-Activators | 1994 |
Thiangazole, a new thiazoline antibiotic from Polyangium sp. (myxobacteria): production, antimicrobial activity and mechanism of action.
Topics: Animals; Anti-Bacterial Agents; Cattle; Humans; Microbial Sensitivity Tests; Mitochondria, Heart; Myxococcales; Oxazoles; Oxidation-Reduction; Thiazoles | 1993 |
Synthesis and biological evaluation of 5-[[3,5-bis(1,1-dimethylethyl)- 4-hydroxyphenyl]methylene]oxazoles, -thiazoles, and -imidazoles: novel dual 5-lipoxygenase and cyclooxygenase inhibitors with antiinflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Imidazoles; Lipoxygenase Inhibitors; Oxazoles; Rats; Structure-Activity Relationship; Thiazoles; Tumor Cells, Cultured | 1994 |
The chemistry of pseudomonic acid. Part 14. Synthesis and in vivo biological activity of heterocyclyl substituted oxazole derivatives.
Topics: Animals; Anti-Bacterial Agents; Furans; Humans; Isoxazoles; Mice; Mupirocin; Oxazoles; Pyrazoles; Pyridines; Sepsis; Staphylococcal Infections; Thiazoles; Thiophenes | 1995 |
Azole phenoxy hydroxyureas as selective and orally active inhibitors of 5-lipoxygenase.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Bronchoconstriction; Guinea Pigs; Humans; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Macrophages; Mice; Molecular Structure; Monocytes; Oxazoles; Rats; Structure-Activity Relationship; Thiazoles | 1996 |
Dose proportionality studies of novel thiazolidinedione derivatives as potent antidiabetic agents in mice.
Topics: Animals; Benzofurans; Chromatography, High Pressure Liquid; Half-Life; Hypoglycemic Agents; Male; Mice; Mice, Inbred Strains; Naphthalenes; Oxazoles; Oxazolidinones; Spectrophotometry, Ultraviolet; Thiazoles; Thiazolidinediones | 1995 |
The mode of rabbit platelet shape change and aggregation induced by theonezolide-A, a novel polyketide macrolide, isolated from the Okinawan marine sponge Theonella sp.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Calcium; Calcium Channel Blockers; Cell Size; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; Isoflavones; Male; Oxazoles; Platelet Aggregation; Porifera; Protein-Tyrosine Kinases; Rabbits; Thiazoles; Verapamil | 1996 |
E2011 a novel, selective and reversible inhibitor of monoamine oxidase type A.
Topics: Animals; Benzothiazoles; Brain; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred Strains; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Motor Activity; Oxazoles; Oxazolidinones; Rats; Rats, Wistar; Serotonin; Thiazoles | 1996 |
Hypoglycemic activity of a series of alpha-alkylthio and alpha-alkoxy carboxylic acids related to ciglitazone.
Topics: 3T3 Cells; Adipocytes; Animals; Benzofurans; Carboxylic Acids; Diabetes Mellitus, Type 2; Hypoglycemic Agents; Mice; Mice, Mutant Strains; Mice, Obese; Molecular Structure; Oxazoles; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Thiazolidinediones | 1996 |
From peptide precursors to oxazole and thiazole-containing peptide antibiotics: microcin B17 synthase.
Topics: Adenosine Triphosphate; Anti-Bacterial Agents; Bacterial Proteins; Bacteriocins; Enzyme Inhibitors; Escherichia coli; Molecular Weight; Multienzyme Complexes; Operon; Oxazoles; Oxidation-Reduction; Oxygen; Protein Precursors; Protein Processing, Post-Translational; Substrate Specificity; Thiazoles; Topoisomerase II Inhibitors | 1996 |
Stereoselective determination of a new antidepressant, E2011, and its diastereoisomer as a metabolite by high-performance liquid chromatography.
Topics: Animals; Antidepressive Agents; Benzothiazoles; Chromatography, High Pressure Liquid; Drug Stability; Hydrogen-Ion Concentration; Male; Monoamine Oxidase Inhibitors; Oxazoles; Oxazolidinones; Rats; Rats, Sprague-Dawley; Stereoisomerism; Thiazoles | 1997 |
Absorption, distribution, metabolism and excretion of a new, 14C-labelled oxazolidinone MAO-A inhibitor in rat and dog.
Topics: Absorption; Animals; Benzothiazoles; Biliary Tract; Blood Proteins; Carbon Radioisotopes; Dogs; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxazoles; Oxazolidinones; Protein Binding; Rats; Rats, Sprague-Dawley; Thiazoles; Tissue Distribution | 1997 |
Identification of the metabolites of a new oxazolidinone MAO-A inhibitor in rat.
Topics: Animals; Benzothiazoles; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Hydroxylation; Magnetic Resonance Spectroscopy; Male; Methylation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxazoles; Oxazolidinones; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Fast Atom Bombardment; Thiazoles | 1997 |
Quantitative structure-activity studies of octopaminergic 2-(arylimino)thiazolidines and oxazolidines against the nervous system of Periplaneta americana L.
Topics: Animals; Computer Simulation; Enzyme Activation; Imines; Kinetics; Models, Molecular; Nervous System; Octopamine; Oxazoles; Periplaneta; Structure-Activity Relationship; Thiazoles | 1997 |
Synthesis and anticonvulsant activity of 2(3H)-benzoxazolone and 2(3H)-benzothiazolone derivatives.
Topics: Animals; Anticonvulsants; Electric Stimulation; Injections, Intraperitoneal; Male; Mice; Oxazoles; Rats; Seizures; Thiazoles | 1998 |
Species differences and mechanism of the epimerization of a new MAO-A inhibitor.
Topics: Administration, Oral; Animals; Benzothiazoles; Dogs; Guinea Pigs; Haplorhini; Isomerism; Mice; Monoamine Oxidase Inhibitors; Oxazoles; Oxazolidinones; Rats; Species Specificity; Thiazoles | 1998 |
Kinetics and regioselectivity of peptide-to-heterocycle conversions by microcin B17 synthetase.
Topics: Anti-Bacterial Agents; Bacterial Proteins; Bacteriocins; Escherichia coli; Ligases; Oxazoles; Protein Processing, Post-Translational; Substrate Specificity; Thiazoles | 1998 |
ATP/GTP hydrolysis is required for oxazole and thiazole biosynthesis in the peptide antibiotic microcin B17.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Amino Acid Sequence; Anti-Bacterial Agents; Bacterial Proteins; Bacteriocins; GTP Phosphohydrolases; Guanosine Triphosphate; Hydrolysis; Molecular Sequence Data; Multienzyme Complexes; Oxazoles; Peptides; Substrate Specificity; Thiazoles | 1998 |
Substituted tetrahydropyrrolo[2,1-b]oxazol-5(6H)-ones and tetrahydropyrrolo[2,1-b]thiazol-5(6H)-ones as hypoglycemic agents.
Topics: Animals; Cell Line; Diabetes Mellitus, Type 2; Drug Evaluation, Preclinical; Glucose; Hypoglycemic Agents; Male; Mice; Mice, Inbred C57BL; Muscles; Oxazoles; Pyrroles; Rats; Structure-Activity Relationship; Thiazoles | 1998 |
N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 2. Structure-activity relationship and optimization of the phenyl alkyl ether moiety.
Topics: Adipocytes; Animals; Cell Differentiation; Cell Line; DNA-Binding Proteins; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Ligands; Lipids; Mice; Oxazoles; Propionates; Radioligand Assay; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Solubility; Structure-Activity Relationship; Thiazoles; Transcription Factors; Transfection; Tyrosine | 1998 |
[3H]Rilmenidine-labelled imidazoline-receptor binding sites co-localize with [3H]2-(benzofuranyl)-2-imidazoline-labelled imidazoline-receptor binding sites and monoamine oxidase-B in rabbit, but not rat, kidney.
Topics: Adrenergic alpha-Agonists; Animals; Autoradiography; Benzofurans; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Isoenzymes; Kidney; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxazoles; Picolinic Acids; Rabbits; Rats; Rats, Inbred WKY; Receptors, Drug; Rilmenidine; Species Specificity; Thiazoles | 1998 |
Pharmacology and subcellular distribution of [3H]rilmenidine binding sites in rat brain.
Topics: Adrenergic alpha-Agonists; Animals; Binding Sites; Brain; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Male; Membranes; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxazoles; Picolinic Acids; Radioligand Assay; Rats; Rats, Inbred WKY; Receptors, Drug; Rilmenidine; Subcellular Fractions; Thiazoles | 1998 |
Effects of rhizopodin and latrunculin B on the morphology and on the actin cytoskeleton of mammalian cells.
Topics: Actins; Animals; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cytoskeleton; Fibroblasts; Fluorescent Antibody Technique; Kidney; Macrolides; Mice; Microscopy, Electron; Oxazoles; Thiazoles; Thiazolidines | 1999 |
Ab initio calculations on peptide-derived oxazoles and thiazoles: improved molecular mechanics parameters for the AMBER force field.
Topics: Models, Molecular; Oxazoles; Peptides, Cyclic; Protein Conformation; Software; Thermodynamics; Thiazoles | 1999 |
Novel structural templates for estrogen-receptor ligands and prospects for combinatorial synthesis of estrogens.
Topics: Binding Sites; Estradiol; Estrogen Antagonists; Estrogens; Imidazoles; Isoxazoles; Ligands; Models, Molecular; Oxazoles; Piperidines; Protein Conformation; Pyrazoles; Raloxifene Hydrochloride; Receptors, Estrogen; Thiazoles; X-Ray Diffraction | 1999 |
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 1. Thiazolone and oxazolone series.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Edema; Gastric Mucosa; Humans; Hyperalgesia; Isoenzymes; Male; Membrane Proteins; Mice; Oxazoles; Phenols; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Structure-Activity Relationship; Thiazoles | 1999 |
Cofactor requirements and reconstitution of microcin B17 synthetase: a multienzyme complex that catalyzes the formation of oxazoles and thiazoles in the antibiotic microcin B17.
Topics: Amino Acid Sequence; Bacterial Proteins; Bacteriocins; Base Sequence; Blotting, Western; Catalysis; Coenzymes; DNA Primers; Fourier Analysis; Mass Spectrometry; Molecular Sequence Data; Multienzyme Complexes; Oxazoles; Photoaffinity Labels; Recombinant Proteins; Sequence Homology, Amino Acid; Thiazoles | 1999 |
Identification of imidazoline-receptor binding sites in cortex and medulla of the bovine adrenal gland. Colocalization with MAO-A and MAO-B.
Topics: Adrenal Cortex; Adrenal Medulla; Adrenergic beta-Agonists; Animals; Autoradiography; Benzofurans; Binding Sites; Cattle; Clonidine; Imidazoles; Imidazoline Receptors; Isoenzymes; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxazoles; Picolinic Acids; Rats; Receptors, Drug; Rilmenidine; Thiazoles; Tritium | 1999 |
Toxicological response of rats to a novel monoamine oxidase type-A inhibitor, (5R)-3-[2-((1S)-3-cyano-1-hydroxypropyl)benzothiazol-6-yl]-5- methoxymethyl-2-oxazolidinone (E2011), orally administered for 13 weeks.
Topics: Administration, Oral; Animals; Benzothiazoles; Body Weight; Eating; Female; Glutathione S-Transferase pi; Glutathione Transferase; Harderian Gland; Hematologic Tests; Isoenzymes; Liver; Liver Neoplasms, Experimental; Male; Monoamine Oxidase Inhibitors; Organ Size; Oxazoles; Oxazolidinones; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Salivation; Thiazoles | 1999 |
Synthesis and antimicrobial activity in vitro of new amino acids and peptides containing thiazole and oxazole moieties.
Topics: Amino Acids; Anti-Bacterial Agents; Bacteria; Microbial Sensitivity Tests; Oxazoles; Peptides; Thiazoles | 1999 |
Synthesis of thiazole, imidazole and oxazole containing amino acids for peptide backbone modification.
Topics: Amino Acids; Anti-Bacterial Agents; Bacteriocins; Imidazoles; Molecular Mimicry; Oxazoles; Peptides; Thiazoles | 1999 |
[Application of ring-chain tautomerism for the development of prodrugs].
Topics: Cysteine; Drug Design; Ephedrine; Hydrocortisone; Molecular Structure; Oxazoles; Prodrugs; Stereoisomerism; Thiazoles | 1999 |
Chronic and acute effects of thiazolidinediones BM13.1258 and BM15.2054 on rat skeletal muscle glucose metabolism.
Topics: Animals; Biological Transport; Body Weight; Cell Line; Deoxyglucose; Glucose; In Vitro Techniques; Insulin; Ligands; Male; Muscle, Skeletal; Obesity; Oxazoles; Rats; Rats, Sprague-Dawley; Rats, Zucker; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Thiazoles; Thiazolidinediones; Transcription Factors; Weight Gain | 1999 |
Alpha(2) adrenoceptor agonists as potential analgesic agents. 1. (Imidazolylmethyl)oxazoles and -thiazoles.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Analgesics; Animals; Dogs; Magnetic Resonance Spectroscopy; Male; Mice; Molecular Structure; Oxazoles; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Thiazoles | 1999 |
A role for the actin cytoskeleton in the initiation and maintenance of store-mediated calcium entry in human platelets. Evidence for conformational coupling.
Topics: Actins; Biological Transport; Blood Platelets; Brefeldin A; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cell Membrane; Cytochalasin D; Cytoskeleton; Depsipeptides; Endoplasmic Reticulum; Humans; Inositol 1,4,5-Trisphosphate; Marine Toxins; Models, Biological; Oxazoles; Peptides, Cyclic; Thiazoles; Thiazolidines | 2000 |
Computational analysis of the first biheterocyclization site of the antibiotic microcin B17.
Topics: Anti-Bacterial Agents; Bacteriocins; Computer Simulation; Cyclization; Green Fluorescent Proteins; Luminescent Proteins; Monte Carlo Method; Oxazoles; Protein Conformation; Protein Processing, Post-Translational; Thiazoles | 2000 |
The F-actin cytoskeleton modulates slow secretory components rather than readily releasable vesicle pools in bovine chromaffin cells.
Topics: Actins; Adrenal Glands; Animals; Bridged Bicyclo Compounds, Heterocyclic; Carcinogens; Cattle; Cell Membrane; Chromaffin Cells; Cytoplasmic Granules; Cytoskeleton; Electrophysiology; Enzyme Inhibitors; Exocytosis; Marine Toxins; Membrane Potentials; Microscopy, Electron; Oxazoles; Phosphorylation; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidines | 2000 |
A spectroscopic and magnetic study of complexes of bis(2-benzothiazolyl)methanate and bis(2-benzoxazolyl)methanate with Co(II), Ni(II), Cu(II) and Zn(II).
Topics: Benzoxazoles; Cations, Divalent; Cobalt; Copper; Magnetics; Molecular Structure; Nickel; Organometallic Compounds; Oxazoles; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Thiazoles; Zinc | 2000 |
Zinc biosensing with multiphoton excitation using carbonic anhydrase and improved fluorophores.
Topics: Anisotropy; Benzothiazoles; Carbonic Anhydrases; Coumarins; Fluorescent Dyes; Humans; Oxazoles; Spectrometry, Fluorescence; Sulfonamides; Thiazoles; Zinc | 2000 |
Peroxisome proliferator-activated receptor gamma ligands inhibit development of atherosclerosis in LDL receptor-deficient mice.
Topics: Animals; Arteriosclerosis; Base Sequence; CD36 Antigens; DNA Primers; Female; Gene Expression; Humans; Insulin Resistance; Ligands; Male; Matrix Metalloproteinase 9; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxazoles; Receptors, Cytoplasmic and Nuclear; Receptors, Immunologic; Receptors, LDL; Receptors, Lipoprotein; Receptors, Scavenger; RNA, Messenger; Rosiglitazone; Scavenger Receptors, Class B; Thiazoles; Thiazolidinediones; Transcription Factors; Tumor Necrosis Factor-alpha; Tyrosine | 2000 |
Phenyloxazoles and phenylthiazoles as benzamide bioisosteres: synthesis and dopamine receptor binding profiles.
Topics: Antipsychotic Agents; Benzamides; Humans; Oxazoles; Receptors, Dopamine; Structure-Activity Relationship; Thiazoles | 2000 |
2,4-Disubstituted oxazoles and thiazoles as latent pharmacophores for diacylhydrazine of SC-51089, a potent PGE2 antagonist.
Topics: Dinoprostone; Hydrazines; Oxazepines; Oxazoles; Thiazoles | 2001 |
Non-thiazolidinedione insulin sensitiser shows promise.
Topics: Clinical Trials, Phase III as Topic; Diabetes Mellitus, Type 2; Drug Industry; Humans; Hypoglycemic Agents; Multicenter Studies as Topic; Oxazoles; Thiazoles; Tyrosine | 2000 |
Synthesis, absolute configuration, and enantiomeric enrichment of a cruciferous oxindole phytoalexin, (S)-(-)-spirobrassinin, and its oxazoline analog.
Topics: Antifungal Agents; Ascomycota; Brassicaceae; Circular Dichroism; Crystallography, X-Ray; Microbial Sensitivity Tests; Molecular Conformation; Oxazoles; Spectrophotometry, Ultraviolet; Spiro Compounds; Stereoisomerism; Thiazoles | 2001 |
Calyculin-A induces focal adhesion assembly and tyrosine phosphorylation of p125(Fak), p130(Cas), and paxillin in Swiss 3T3 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Animals; Bombesin; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Crk-Associated Substrate Protein; Cytochalasin D; Cytoskeletal Proteins; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Immunoblotting; Indoles; Maleimides; Marine Toxins; Mice; Microscopy, Fluorescence; Myosin-Light-Chain Phosphatase; Nucleic Acid Synthesis Inhibitors; Oxazoles; Paxillin; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Proteins; Retinoblastoma-Like Protein p130; Thiazoles; Thiazolidines; Time Factors | 2001 |
Heterocycle formation in vibriobactin biosynthesis: alternative substrate utilization and identification of a condensed intermediate.
Topics: Amines; Amino Acid Substitution; Bacterial Proteins; Benzoates; Catalysis; Catechols; Cloning, Molecular; Escherichia coli; Esters; Heterocyclic Compounds; Oxazoles; Peptide Synthases; Substrate Specificity; Thiazoles; Threonine; Vibrio cholerae | 2001 |
Potentiation of glucose uptake in 3T3-L1 adipocytes by PPAR gamma agonists is maintained in cells expressing a PPAR gamma dominant-negative mutant: evidence for selectivity in the downstream responses to PPAR gamma activation.
Topics: 3T3 Cells; Adenoviridae; Adipocytes; Animals; Benzophenones; Cell Membrane; Drug Synergism; Gene Expression; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 4; Green Fluorescent Proteins; Hypoglycemic Agents; Insulin; Luminescent Proteins; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Mutation; Oxazoles; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transfection; Tyrosine | 2001 |
Pseudoproline-containing analogues of morphiceptin and endomorphin-2: evidence for a cis Tyr-Pro amide bond in the bioactive conformation.
Topics: Animals; Brain; Endorphins; Guinea Pigs; Ileum; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Mice; Muscle Contraction; Muscle, Smooth; Oligopeptides; Oxazoles; Proline; Protein Conformation; Radioligand Assay; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Thiazoles; Vas Deferens | 2001 |
Synthesis of nodulisporic acid 2' '-oxazoles and 2' '-thiazoles.
Topics: Animals; Indoles; Insecticides; Oxazoles; Siphonaptera; Thiazoles; Ticks | 2001 |
Trypanosoma cruzi: inhibition of parasite growth and respiration by oxazolo(thiazolo)pyridine derivatives and its relationship to redox potential and lipophilicity.
Topics: Animals; Lipid Metabolism; Oxazoles; Oxidation-Reduction; Oxygen Consumption; Pyridines; Structure-Activity Relationship; Thiazoles; Trypanosoma cruzi | 2001 |
Anti-Helicobacter pylori agents. 5. 2-(Substituted guanidino)-4-arylthiazoles and aryloxazole analogues.
Topics: Animals; Anti-Bacterial Agents; Colony Count, Microbial; Gastric Juice; Guanidines; Guinea Pigs; Helicobacter pylori; Histamine H2 Antagonists; In Vitro Techniques; Male; Microbial Sensitivity Tests; Myocardium; Oxazoles; Rats; Structure-Activity Relationship; Thiazoles; Thiophenes | 2002 |
Potent, novel in vitro inhibitors of the Pseudomonas aeruginosa deacetylase LpxC.
Topics: Amidohydrolases; Combinatorial Chemistry Techniques; Enzyme Inhibitors; Oxazines; Oxazoles; Pseudomonas aeruginosa; Stereoisomerism; Structure-Activity Relationship; Thiazoles | 2002 |
Peroxisome proliferator-activated receptor-gamma agonists prevent experimental autoimmune encephalomyelitis.
Topics: Animals; Cerebellum; Cerebral Cortex; DNA-Binding Proteins; Encephalomyelitis, Autoimmune, Experimental; Female; Glycoproteins; Humans; Hypoglycemic Agents; I-kappa B Proteins; Ligands; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin-Oligodendrocyte Glycoprotein; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxazoles; Peptide Fragments; Pioglitazone; Receptors, Cytoplasmic and Nuclear; Remission Induction; Spinal Cord; T-Lymphocytes; Thiazoles; Thiazolidinediones; Transcription Factors; Tyrosine | 2002 |
Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta.
Topics: Animals; Blood Glucose; Carrier Proteins; Energy Metabolism; Fatty Acids; Fatty Acids, Nonesterified; Homeostasis; Humans; Ion Channels; Isoenzymes; Ketones; Lactic Acid; Liver Glycogen; Mice; Mice, Knockout; Mitochondrial Proteins; Muscle, Skeletal; Oxazoles; Oxidation-Reduction; Physical Conditioning, Animal; Protein Kinases; Rats; Receptors, Cytoplasmic and Nuclear; Thiazoles; Transcription Factors; Transcription, Genetic; Tyrosine; Uncoupling Protein 3 | 2002 |
Sonogashira coupling of functionalized trifloyl oxazoles and thiazoles with terminal alkynes: synthesis of disubstituted heterocycles.
Topics: Alkynes; Catalysis; Chemistry, Pharmaceutical; Heterocyclic Compounds; Oxazoles; Palladium; Thiazoles | 2002 |
Discovery of aminothiazole inhibitors of cyclin-dependent kinase 2: synthesis, X-ray crystallographic analysis, and biological activities.
Topics: Animals; Antineoplastic Agents; Benzeneacetamides; CDC2-CDC28 Kinases; Cell Cycle; Combinatorial Chemistry Techniques; Crystallography, X-Ray; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA Polymerase I; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Female; Histones; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Models, Molecular; Oxazoles; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Retinoblastoma Protein; Structure-Activity Relationship; Thiazoles; Tumor Cells, Cultured | 2002 |
A new synthesis of oxadiazole, thiazolidinone, N-phthalimidoamino carbonyl and arylidene derivatives with potential antimicrobial activity.
Topics: Anti-Bacterial Agents; Bacteria; Chemical Phenomena; Chemistry, Physical; Indicators and Reagents; Khellin; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Oxazoles; Phthalimides; Spectrophotometry, Infrared; Thiazoles | 2002 |
Roles of the cytoskeleton and of protein phosphorylation events in the osmotic stress response in eel intestinal epithelium.
Topics: Actins; Alkaloids; Anguilla; Animals; Azepines; Benzophenanthridines; Bridged Bicyclo Compounds, Heterocyclic; Bumetanide; Cell Size; Colchicine; Cytochalasins; Cytoskeleton; Enzyme Inhibitors; Hypertonic Solutions; Hypotonic Solutions; Intestinal Mucosa; Ion Transport; Isoquinolines; Marine Toxins; Microtubules; Naphthalenes; Osmotic Pressure; Oxazoles; Phenanthridines; Phosphorylation; Protein Serine-Threonine Kinases; Sulfonamides; Thiazoles; Thiazolidines | 2002 |
Regioselective synthesis of antiparallel loops on a macrocyclic scaffold constrained by oxazoles and thiazoles.
Topics: Magnetic Resonance Spectroscopy; Molecular Mimicry; Molecular Structure; Oxazoles; Proteins; Thiazoles | 2002 |
Glycoprotein Ib cross-linking/ligation on echicetin-coated surfaces or echicetin-IgMkappa in stirred suspension activates platelets by cytoskeleton modulated calcium release.
Topics: Aspirin; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium Channels; Carrier Proteins; Cell Adhesion; Cytochalasin D; Cytoskeleton; Humans; Immunoglobulin M; Inositol 1,4,5-Trisphosphate Receptors; Macrocyclic Compounds; Nitric Oxide; Oxazoles; Phosphorylation; Platelet Activation; Platelet Glycoprotein GPIb-IX Complex; Proteins; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidines; Tyrosine; Viper Venoms; von Willebrand Factor | 2002 |
Reversible protein phosphorylation regulates the dynamic organization of the pollen tube cytoskeleton: effects of calyculin A and okadaic acid.
Topics: Actin Cytoskeleton; Bridged Bicyclo Compounds, Heterocyclic; Cell Differentiation; Cell Polarity; Cytoskeleton; Enzyme Inhibitors; Fertilization; Flowers; Gene Expression Regulation, Plant; Lilium; Marine Toxins; Microtubules; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Plant Proteins; Thiazoles; Thiazolidines | 2002 |
Three-dimensional common-feature hypotheses of inhibitors of calling behaviour and in vitro [14C]acetate incorporation by pheromone glands of Plodia interpunctella.
Topics: Acetates; Aniline Compounds; Animals; Behavior, Animal; Carbon Radioisotopes; Female; Larva; Lepidoptera; Male; Models, Molecular; Molecular Structure; Octopamine; Oxazoles; Pheromones; Pupa; Thiazoles; Thiazolidines | 2002 |
Peroxisome proliferator-activated receptor gamma-mediated NF-kappa B activation and apoptosis in pre-B cells.
Topics: Animals; Apoptosis; B-Lymphocytes; Bone Marrow Cells; Cell Line; Cell Line, Transformed; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Oxazoles; Peroxisome Proliferators; Peroxisomes; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Signal Transduction; Stem Cells; Thiazoles; Thiazolidinediones; Transcription Factors; Tyrosine | 2002 |
Theonezolide A, a novel marine macrolide, induces drastic shape change in rabbit platelets by reorganization of microtubules.
Topics: Animals; Blood Platelets; Cell Size; Cytochalasin B; In Vitro Techniques; Macrolides; Male; Microscopy, Electron, Scanning; Microtubule Proteins; Microtubules; Oxazoles; Paclitaxel; Rabbits; Thiazoles; Thrombin | 2002 |
Nephrotoxic and hepatotoxic potential of imidazolidinedione-, oxazolidinedione- and thiazolidinedione-containing analogues of N-(3,5-dichlorophenyl)succinimide (NDPS) in Fischer 344 rats.
Topics: Alanine Transaminase; Animals; Blood Glucose; Blood Urea Nitrogen; Chemical and Drug Induced Liver Injury; Fungicides, Industrial; Imidazoles; Kidney Diseases; Liver Diseases; Male; Oxazoles; Proteinuria; Rats; Rats, Inbred F344; Succinimides; Thiazoles | 2003 |
Thiazolidinediones, a class of anti-diabetic drugs, inhibit Id2 expression through a PPARgamma-independent pathway in human aortic smooth muscle cells.
Topics: Anilides; Aorta; Chromans; DNA-Binding Proteins; Dose-Response Relationship, Drug; Down-Regulation; Gene Expression Regulation; Humans; Hypoglycemic Agents; Inhibitor of Differentiation Protein 2; Muscle, Smooth, Vascular; Oxazoles; Receptors, Cytoplasmic and Nuclear; Repressor Proteins; RNA, Messenger; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Troglitazone; Tyrosine | 2003 |
Scope and mechanism of palladium-catalyzed amination of five-membered heterocyclic halides.
Topics: Amination; Benzimidazoles; Catalysis; Chemistry, Organic; Furans; Hydrocarbons, Halogenated; Indicators and Reagents; Indoles; Kinetics; Molecular Structure; Organometallic Compounds; Oxazoles; Palladium; Thiazoles | 2003 |
PPAR gamma-dependent anti-inflammatory action of rosiglitazone in human monocytes: suppression of TNF alpha secretion is not mediated by PTEN regulation.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromones; Enzyme Activation; Enzyme Inhibitors; Humans; In Vitro Techniques; Monocytes; Morpholines; Oxazoles; Phosphoinositide-3 Kinase Inhibitors; Phosphoric Monoester Hydrolases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Tumor Necrosis Factor-alpha; Tumor Suppressor Proteins; Tyrosine | 2003 |
Design and synthesis of some substituted 1H-pyrazolyl-oxazolidines or 1H-pyrazolyl-thiazolidines as anti-inflammatory-antimicrobial agents.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Candida albicans; Drug Design; Escherichia coli; Infusions, Parenteral; Lethal Dose 50; Male; Mice; Oxazoles; Pyrazoles; Rats; Rats, Sprague-Dawley; Staphylococcus aureus; Stomach Ulcer; Structure-Activity Relationship; Thiazoles; Toxicity Tests, Acute | 2003 |
Possible involvement of energy metabolism in the change of cytoplasm organization induced by a protein phosphatase inhibitor, calyculin A, in root hair cells of Limnobium stoloniferum.
Topics: Actins; Bridged Bicyclo Compounds, Heterocyclic; Carbazoles; Cytoplasm; Enzyme Inhibitors; Hydrocharitaceae; Indole Alkaloids; Marine Toxins; Myosins; Oxazoles; Phosphoprotein Phosphatases; Plant Roots; Sodium Nitrite; Thiazoles; Thiazolidines | 2003 |
Ni(II) bis(oxazoline)-catalyzed enantioselective syn aldol reactions of N-propionylthiazolidinethiones in the presence of silyl triflates.
Topics: Alcohols; Ketones; Models, Molecular; Nickel; Organometallic Compounds; Oxazoles; Silanes; Stereoisomerism; Thiazoles | 2003 |
Synthesis of an oxazoline analogue of apratoxin A.
Topics: Antineoplastic Agents; Cyclization; Cytotoxins; Depsipeptides; Ketones; Lactones; Models, Chemical; Molecular Structure; Oxazoles; Peptides; Peptides, Cyclic; Proline; Stereoisomerism; Structure-Activity Relationship; Thiazoles | 2003 |
Studies on acetylenic compounds. XXV. Ring closure. (5). New synthetic method of heterocyclic compounds from alpha-amino- and alpha-N-substituted amino- acetylenic compounds.
Topics: Acetylene; Alkynes; Heterocyclic Compounds; Imidazoles; Oxazoles; Thiazoles | 1962 |
Studies on acetylenic compounds. XXVI. Ring closure. (6). New synthetic method of heterocyclic compounds from alpha-substituted acetylenic compounds.
Topics: Acetylene; Alkynes; Heterocyclic Compounds; Oxazoles; Thiazoles | 1962 |
Convenient routes to medicinally important heterocycles.
Topics: Benzimidazoles; Chemistry, Pharmaceutical; Heterocyclic Compounds; Oxazoles; Pharmacy; Thiazoles | 1962 |
EFFECT ON CATALASE IN VIVO AND IN VITRO OF COMPOUNDS RELATED TO AMINOTRIAZOLE. ANL-6823.
Topics: Amitrole; Azides; Azoles; Catalase; Enzyme Inhibitors; Erythrocytes; Imidazoles; In Vitro Techniques; Isoniazid; Kidney; Liver; Oxadiazoles; Oxazoles; Oxidation-Reduction; Pentylenetetrazole; Pharmacology; Pyrazoles; Rats; Research; Thiazoles; Triazoles | 1964 |
SOME ELECTRONIC ASPECTS OF THE MECHANISM OF THIAMINE ACTION.
Topics: Catalysis; Chemical Phenomena; Chemistry; Deuterium; Electrons; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Oxazoles; Research; Sulfur; Thiamine; Thiazoles | 1964 |
Total synthesis of dendroamide a: oxazole and thiazole construction using an oxodiphosphonium salt.
Topics: Amino Acids; Cyclization; Models, Chemical; Molecular Structure; Organophosphorus Compounds; Oxazoles; Peptides; Peptides, Cyclic; Stereoisomerism; Thiazoles | 2003 |
Synthesis of some functionalized arylaminomethyl-1 ,2,4-triazoles, 1,3,4-oxa- and thiadiazoles.
Topics: Antiviral Agents; Cell Line; Cell Survival; Drug Screening Assays, Antitumor; Enzyme-Linked Immunosorbent Assay; Hepatitis B virus; Humans; Indicators and Reagents; Magnetic Resonance Spectroscopy; Methylation; Oxazoles; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Triazoles | 2003 |
Facile syntheses of oxazolines and thiazolines with N-acylbenzotriazoles under microwave irradiation.
Topics: Microwaves; Oxazoles; Thiazoles; Triazoles | 2004 |
N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent.
Topics: Animals; Antineoplastic Agents; CDC2-CDC28 Kinases; Cell Line, Tumor; Cell-Free System; Crystallography, X-Ray; Cyclin E; Cyclin-Dependent Kinase 2; Dogs; Drug Screening Assays, Antitumor; Drug Stability; Humans; In Vitro Techniques; Mice; Microsomes, Liver; Models, Molecular; Molecular Structure; Neoplasm Transplantation; Oxazoles; Phosphorylation; Rats; Retinoblastoma Protein; Structure-Activity Relationship; Thiazoles; Transplantation, Heterologous | 2004 |
Design of new cognition enhancers: from computer prediction to synthesis and biological evaluation.
Topics: Amnesia; Animals; Avoidance Learning; Computer Simulation; Drug Design; Male; Nootropic Agents; Oxazoles; Rats; Scopolamine; Thiazoles | 2004 |
Novel p38 inhibitors with potent oral efficacy in several models of rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Collagen; Disease Models, Animal; Enzyme Inhibitors; Imidazoles; Lipopolysaccharides; Mice; Oxazoles; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Structure-Activity Relationship; Thiazoles; Tumor Necrosis Factor-alpha | 2004 |
P-glycoprotein plays a role in the oral absorption of BMS-387032, a potent cyclin-dependent kinase 2 inhibitor, in rats.
Topics: Absorption; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Brain; Caco-2 Cells; Cell Cycle Proteins; Cyclin-Dependent Kinase Inhibitor p21; Dogs; Humans; Male; Mice; Microsomes, Liver; Oxazoles; Photoaffinity Labels; Rats; Rats, Sprague-Dawley; Thiazoles | 2005 |
alpha 2-adrenoreceptors profile modulation. 2. Biphenyline analogues as tools for selective activation of the alpha 2C-subtype.
Topics: Adrenergic alpha-2 Receptor Agonists; Amino Acid Sequence; Animals; Biphenyl Compounds; CHO Cells; Cricetinae; Cricetulus; Humans; Imidazoles; Models, Molecular; Molecular Sequence Data; Oxazoles; Radioligand Assay; Receptors, Adrenergic, alpha-2; Sequence Homology, Amino Acid; Stereoisomerism; Structure-Activity Relationship; Thiazoles | 2004 |
E2F4 deficiency promotes drug-induced apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Cycle Proteins; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; E2F4 Transcription Factor; Fibroblasts; Flavonoids; Humans; Lung Neoplasms; Mice; Mice, Knockout; Oxazoles; Piperidines; Protein Kinase Inhibitors; Purines; RNA, Small Interfering; Roscovitine; Thiazoles; Transcription Factors; Tumor Cells, Cultured | 2004 |
Exploring the binding site structure of the PPAR gamma ligand-binding domain by computational solvent mapping.
Topics: Alkanesulfonates; Binding Sites; Cinnamates; Computational Biology; Humans; Ligands; Oxazines; Oxazoles; Phenylpropionates; PPAR gamma; Protein Binding; Protein Conformation; Protein Interaction Mapping; Protein Structure, Tertiary; Rosiglitazone; Solvents; Thiazoles; Thiazolidinediones; Thiazolidines; Tyrosine | 2005 |
Incorporation of pseudoproline derivatives allows the facile synthesis of human IAPP, a highly amyloidogenic and aggregation-prone polypeptide.
Topics: Amino Acid Sequence; Amyloid; Dipeptides; Humans; Islet Amyloid Polypeptide; Molecular Sequence Data; Oxazoles; Proline; Thiazoles | 2005 |
Efficient synthesis of bicyclic oxazolino- and thiazolino[3,2-c]pyrimidine-5,7-diones and its application to the synthesis of GnRH antagonists.
Topics: Binding, Competitive; Bridged Bicyclo Compounds; Cyclization; Humans; Molecular Structure; Oxazoles; Pyrimidinones; Receptors, LHRH; Structure-Activity Relationship; Thiazoles | 2005 |
Dipeptidyl peptidase IV inhibitors derived from beta-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole.
Topics: Dipeptidyl Peptidase 4; Isoxazoles; Oxazoles; Piperidines; Protease Inhibitors; Pyrazoles; Thiazoles | 2005 |
Peroxisome proliferator-activated receptor delta and gamma agonists differentially alter tumor differentiation and progression during mammary carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Carcinoma, Adenosquamous; Carcinoma, Ductal; Carcinoma, Squamous Cell; Cell Differentiation; Disease Progression; Female; Gene Expression Profiling; Mammary Neoplasms, Experimental; Mice; Oxazoles; PPAR delta; PPAR gamma; Thiazoles; Tyrosine | 2005 |
Structural mimicry of two cytochrome b(562) interhelical loops using macrocycles constrained by oxazoles and thiazoles.
Topics: Biomimetic Materials; Cytochrome b Group; Escherichia coli Proteins; Macrocyclic Compounds; Models, Molecular; Oxazoles; Protein Structure, Quaternary; Solutions; Surface Properties; Thiazoles | 2005 |
Molybdenum oxides as highly effective dehydrative cyclization catalysts for the synthesis of oxazolines and thiazolines.
Topics: Catalysis; Cyclization; Cysteine; Molybdenum; Oxazoles; Serine; Thiazoles; Threonine | 2005 |
Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells.
Topics: Butyrates; Cells, Cultured; Fatty Acids; Gene Expression Regulation, Enzymologic; Glucose; Humans; Insulin; Isoenzymes; Muscle Fibers, Skeletal; Muscle, Skeletal; Myoblasts, Skeletal; Oxazoles; Phenylurea Compounds; PPAR alpha; PPAR delta; PPAR gamma; Protein Kinases; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; RNA, Messenger; Thiazoles; Tyrosine | 2005 |
Mechercharmycins A and B, cytotoxic substances from marine-derived Thermoactinomyces sp. YM3-251.
Topics: Antibiotics, Antineoplastic; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Dipeptides; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Micromonosporaceae; Models, Molecular; Molecular Conformation; Oxazoles; Peptides, Cyclic; Spectrometry, Mass, Fast Atom Bombardment; Thiazoles | 2005 |
Samarium Barbier reactions of alpha-iodomethyloxazoles and thiazoles with aliphatic aldehydes.
Topics: Aldehydes; Heterocyclic Compounds, 4 or More Rings; Iodine; Methylation; Molecular Structure; Oxazoles; Samarium; Thiazoles | 2005 |
Synthesis and biological evaluation of novel bisheterocycle-containing compounds as potential anti-influenza virus agents.
Topics: Alphainfluenzavirus; Antiviral Agents; Humans; Oxazoles; Thiazoles | 2005 |
Disturbance of endomembrane trafficking by brefeldin A and calyculin A reorganizes the actin cytoskeleton of Lilium longiflorum pollen tubes.
Topics: Actin Cytoskeleton; Actins; Brefeldin A; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cytochalasin B; Flowers; Lilium; Marine Toxins; Models, Biological; Oxazoles; Phosphatidate Phosphatase; Phosphorylation; Protein Transport; Thiazoles; Thiazolidines | 2005 |
The cyclin-dependent kinase 2 inhibitor down-regulates interleukin-1beta-mediated induction of cyclooxygenase-2 expression in human lung carcinoma cells.
Topics: Carcinoma, Non-Small-Cell Lung; CCAAT-Enhancer-Binding Proteins; Cell Line, Tumor; Cyclin-Dependent Kinase 2; Cyclooxygenase 2; Dinoprostone; Down-Regulation; Enzyme Induction; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Interleukin-1; Lung Neoplasms; Oxazoles; Promoter Regions, Genetic; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Thiazoles; Transcription, Genetic; Transfection | 2006 |
Spectrofluorimetric and spectrophotometric stability-indicating methods for determination of some oxicams using 7-chloro-4-nitrobenz-2-oxa-1,3-diazole (NBD-Cl).
Topics: Anti-Inflammatory Agents, Non-Steroidal; Buffers; Capsules; Drug Stability; Hydrogen-Ion Concentration; Indicators and Reagents; Meloxicam; Nitrobenzenes; Oxazoles; Pharmaceutical Solutions; Piroxicam; Powders; Reproducibility of Results; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Tablets; Thiazines; Thiazoles | 2006 |
Solid-phase synthesis of 1,3-azole-based peptides and peptidomimetics.
Topics: Amino Acids; Azoles; Combinatorial Chemistry Techniques; Imidazoles; Molecular Mimicry; Oxazoles; Peptides; Serine; Thiazoles; Threonine | 2006 |
Asymmetric Michael addition of nitroalkanes to nitroalkenes catalyzed by C2-symmetric tridentate bis(oxazoline) and bis(thiazoline) zinc complexes.
Topics: Alkanes; Alkenes; Carbon; Catalysis; Models, Chemical; Nitro Compounds; Organometallic Compounds; Oxazoles; Thiazoles; Zinc | 2006 |
Transcriptional upregulation of p57 (Kip2) by the cyclin-dependent kinase inhibitor BMS-387032 is E2F dependent and serves as a negative feedback loop limiting cytotoxicity.
Topics: Binding Sites; Cell Cycle; Cell Line; Cyclin-Dependent Kinase Inhibitor p57; Cyclin-Dependent Kinases; E2F Transcription Factors; E2F1 Transcription Factor; Enzyme Inhibitors; Feedback, Physiological; Gene Expression Regulation; Humans; Oxazoles; Promoter Regions, Genetic; Thiazoles; Transcription, Genetic; Up-Regulation | 2007 |
Library synthesis and screening: 2,4-diphenylthiazoles and 2,4-diphenyloxazoles as potential novel prion disease therapeutics.
Topics: Animals; Cell Line; Combinatorial Chemistry Techniques; Humans; Mice; Oxazoles; Prion Diseases; Protein Binding; PrPC Proteins; PrPSc Proteins; Structure-Activity Relationship; Surface Plasmon Resonance; Thiazoles | 2007 |
Surface chemistry of five-membered aromatic ring molecules containing two different heteroatoms on Si(111)-7 x 7.
Topics: Androstenols; Molecular Structure; Oxazoles; Silicon; Spectrum Analysis; Thiazoles | 2007 |
4-Aryl-1,3,2-oxathiazolylium-5-olates as pH-controlled NO-donors: the next generation of S-nitrosothiols.
Topics: Animals; Chemical Phenomena; Chemistry, Physical; Computational Biology; Electrochemistry; Electron Spin Resonance Spectroscopy; Hydrogen-Ion Concentration; In Vitro Techniques; Indicators and Reagents; Models, Molecular; Nitric Oxide; Nitric Oxide Donors; Oxazoles; Rats; S-Nitrosothiols; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Thermodynamics; Thiazoles; Vasodilator Agents | 2007 |
SNS-032 prevents tumor cell-induced angiogenesis by inhibiting vascular endothelial growth factor.
Topics: Angiogenesis Inhibitors; Cell Movement; Cell Proliferation; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Endothelial Cells; Glioblastoma; Humans; Neovascularization, Pathologic; Oxazoles; Protein Kinase Inhibitors; Thiazoles; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A | 2007 |
Synthesis of libraries of thiazole, oxazole and imidazole-based cyclic peptides from azole-based amino acids. A new synthetic approach to bistratamides and didmolamides.
Topics: Alanine; Amino Acids; Animals; Chemistry, Organic; Chemistry, Pharmaceutical; Imidazoles; Models, Chemical; Oxazoles; Peptides, Cyclic; Thiazoles; Urochordata; Valine | 2007 |
Oxazolones as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Animals; Chemistry, Pharmaceutical; Cortisone; Drug Design; Drug Evaluation, Preclinical; Enzyme Inhibitors; Humans; Hydrocortisone; Models, Chemical; Oxazoles; Rats; Structure-Activity Relationship; Thiazoles | 2007 |
Directed evolution of aryl carrier proteins in the enterobactin synthetase.
Topics: Carrier Proteins; Catalysis; Catechols; Directed Molecular Evolution; Enterobactin; Escherichia coli Proteins; Humans; Ligases; Multienzyme Complexes; Mutagenesis, Site-Directed; Oxazoles; Phenols; Thiazoles; Vibrio cholerae; Yersinia pestis | 2007 |
Aryl triflates: useful coupling partners for the direct arylation of heteroaryl derivatives via Pd-catalyzed C-H activation-functionalization.
Topics: Catalysis; Furans; Mesylates; Oxazoles; Palladium; Thiazoles; Thiophenes | 2008 |
Conversion of a highly selective sigma-1 receptor-ligand to sigma-2 receptor preferring ligands with anticocaine activity.
Topics: Animals; Anticonvulsants; Brain; Cocaine; Cocaine-Related Disorders; In Vitro Techniques; Ligands; Mice; Oxazoles; Piperazines; Radioligand Assay; Rats; Receptors, sigma; Seizures; Sigma-1 Receptor; Structure-Activity Relationship; Thiazoles | 2008 |
Discovery of a widely distributed toxin biosynthetic gene cluster.
Topics: Anti-Bacterial Agents; Bacterial Proteins; Bacteriocins; Heterocyclic Compounds; Humans; Multienzyme Complexes; Multigene Family; Oxazoles; Streptococcus pyogenes; Streptolysins; Thiazoles | 2008 |
Copper(II) coordination chemistry of westiellamide and its imidazole, oxazole, and thiazole analogues.
Topics: Cations, Divalent; Copper; Crystallography, X-Ray; Electron Spin Resonance Spectroscopy; Imidazoles; Models, Molecular; Oxazoles; Peptides, Cyclic; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Thiazoles | 2008 |
Asymmetric Friedel-Crafts alkylation of electron-rich N-heterocycles with nitroalkenes catalyzed by diphenylamine-tethered bis(oxazoline) and bis(thiazoline) Zn(II) complexes.
Topics: Alkenes; Alkylation; Catalysis; Heterocyclic Compounds; Ligands; Nitro Compounds; Oxazoles; Stereoisomerism; Thiazoles | 2008 |
One-photon ionization spectroscopy of jet-cooled oxazole and thiazole: the role of oxygen and sulfur in the pi-conjugation of heterocyclic compounds.
Topics: Cold Temperature; Heterocyclic Compounds; Ions; Models, Molecular; Molecular Conformation; Oxazoles; Oxygen; Photons; Spectrum Analysis; Sulfur; Thiazoles; Vibration | 2008 |
Isolation, structure, and antibacterial activity of thiazomycin A, a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa.
Topics: Actinomycetales; Anti-Bacterial Agents; Inhibitory Concentration 50; Microbial Sensitivity Tests; Oxazoles; Peptides, Cyclic; Staphylococcus aureus; Thiazoles | 2008 |
A diaminocyclohexyl analog of SNS-032 with improved permeability and bioavailability properties.
Topics: Animals; Biological Availability; Mice; Oxazoles; Permeability; Thiazoles | 2008 |
Modifications of the isonipecotic acid fragment of SNS-032: analogs with improved permeability and lower efflux ratio.
Topics: Animals; Combinatorial Chemistry Techniques; Cyclin-Dependent Kinase 2; Isonipecotic Acids; Mice; Molecular Structure; Oxazoles; Stereoisomerism; Structure-Activity Relationship; Thiazoles | 2008 |
Transient treatment with CDK inhibitors eliminates proliferative potential even when their abilities to evoke apoptosis and DNA damage are blocked.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Checkpoint Kinase 1; Cyclin-Dependent Kinases; DNA Damage; Humans; Myeloid Cell Leukemia Sequence 1 Protein; Oxazoles; Protein Kinase Inhibitors; Protein Kinases; Proto-Oncogene Proteins c-bcl-2; Pyrazoles; Pyrimidines; RNA, Small Interfering; Thiazoles; X-Linked Inhibitor of Apoptosis Protein | 2008 |
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cell Line, Tumor; Dogs; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluoresceins; Humans; Kidney; Magnetic Resonance Spectroscopy; Mass Spectrometry; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Oxazoles; Spectrophotometry, Ultraviolet; Thiazoles | 2009 |
Chemistry of polyhalogenated nitrobutadienes, 8: Nitropolychlorobutadienes--precursors for insecticidal neonicotinoids.
Topics: Butadienes; Guanidines; Halogenation; Imidazoles; Imidazolidines; Insecticides; Neonicotinoids; Nitro Compounds; Oxazoles; Pyridines; Thiazines; Thiazoles | 2009 |
The small-molecule CDK inhibitor, SNS-032, enhances cellular radiosensitivity in quiescent and hypoxic non-small cell lung cancer cells.
Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Hypoxia; Cell Line, Tumor; Cyclin-Dependent Kinases; Humans; Lung Neoplasms; Oxazoles; Radiation Tolerance; Thiazoles | 2009 |
The use of phosphonium anhydrides for the synthesis of 2-oxazolines, 2-thiazolines and 2-dihydrooxazine under mild conditions.
Topics: Anhydrides; Organophosphorus Compounds; Oxazines; Oxazoles; Thiazoles | 2009 |
Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia.
Topics: Adult; Aged; Aged, 80 and over; Apoptosis; Caspases; Cyclin-Dependent Kinases; Female; Flavonoids; Humans; Immunoblotting; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Male; Membrane Potential, Mitochondrial; Middle Aged; Myeloid Cell Leukemia Sequence 1 Protein; Oxazoles; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Purines; RNA Polymerase II; RNA, Neoplasm; Roscovitine; Thiazoles; Transcription, Genetic; X-Linked Inhibitor of Apoptosis Protein | 2009 |
Structure elucidation at the nanomole scale. 1. Trisoxazole macrolides and thiazole-containing cyclic peptides from the nudibranch Hexabranchus sanguineus.
Topics: Animals; Gastropoda; Macrolides; Molecular Structure; Nanotechnology; Oxazoles; Peptides, Cyclic; Thiazoles | 2009 |
Novel tricyclic inhibitors of IkappaB kinase.
Topics: Animals; Crystallography, X-Ray; Female; Glutathione Transferase; Heterocyclic Compounds, 3-Ring; Humans; I-kappa B Kinase; Imidazoles; In Vitro Techniques; Leukocytes, Mononuclear; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Microsomes, Liver; Oxazoles; Rats; Recombinant Fusion Proteins; Structure-Activity Relationship; Thiazoles; Tumor Necrosis Factor-alpha | 2009 |
Structural and functional dissection of the heterocyclic peptide cytotoxin streptolysin S.
Topics: Amino Acid Sequence; Animals; Bacterial Proteins; Mice; Molecular Sequence Data; Oxazoles; Proline; Protein Processing, Post-Translational; Sequence Homology, Amino Acid; Streptococcus pyogenes; Streptolysins; Substrate Specificity; Surface Plasmon Resonance; Thiazoles; Virulence | 2009 |
SNS-032 prevents hypoxia-mediated glioblastoma cell invasion by inhibiting hypoxia inducible factor-1alpha expression.
Topics: Antineoplastic Agents; Cell Line, Tumor; Collagen; Cyclooxygenase 2 Inhibitors; DNA Primers; Drug Combinations; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Laminin; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Oxazoles; Proteoglycans; RNA, Small Interfering; Thiazoles; Vascular Endothelial Growth Factor A | 2009 |
Nickel-catalyzed direct arylation of azoles with aryl bromides.
Topics: Azoles; Catalysis; Combinatorial Chemistry Techniques; Hydrocarbons, Brominated; Molecular Structure; Nickel; Oxazoles; Thiazoles | 2009 |
Synthesis of 4-benzyl-1,3-thiazole derivatives as potential anti-inflammatory agents: an analogue-based drug design approach.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Benzyl Compounds; Carrageenan; Dose-Response Relationship, Drug; Drug Design; Edema; Female; Hindlimb; Male; Oxazoles; Plethysmography; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiazoles; Thiazolidines | 2009 |
Metal-induced tautomerization of oxazole and thiazole molecules to heterocyclic carbenes.
Topics: Isomerism; Magnetic Resonance Spectroscopy; Manganese; Metals; Methane; Organogold Compounds; Oxazoles; Thiazoles | 2009 |
Ugi reactions with ammonia offer rapid access to a wide range of 5-aminothiazole and oxazole derivatives.
Topics: Acetamides; Amines; Ammonia; Models, Chemical; Oxazoles; Solvents; Thiazoles; Trifluoroacetic Acid; Trifluoroethanol | 2009 |
Chemoprevention of mouse intestinal tumorigenesis by the cyclin-dependent kinase inhibitor SNS-032.
Topics: ADP-Ribosylation Factor 1; Animals; Apoptosis; Cell Cycle; Colitis; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinases; Female; Intestinal Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxazoles; Phosphorylation; Protein Kinase Inhibitors; Thiazoles | 2009 |
G-quadruplex recognition by macrocyclic hexaoxazole (6OTD) dimer.
Topics: DNA; Fluorescence Resonance Energy Transfer; G-Quadruplexes; Oxazoles; Telomere; Thiazoles | 2009 |
The role of absC, a novel regulatory gene for secondary metabolism, in zinc-dependent antibiotic production in Streptomyces coelicolor A3(2).
Topics: Anthraquinones; Anti-Bacterial Agents; Bacterial Proteins; Base Sequence; Binding Sites; DNA Footprinting; Electrophoretic Mobility Shift Assay; Gene Deletion; Gene Expression Regulation, Bacterial; Models, Biological; Molecular Sequence Data; Oxazoles; Prodigiosin; Promoter Regions, Genetic; Protein Binding; Repressor Proteins; Streptomyces coelicolor; Thiazoles; Zinc | 2009 |
Novel bisaryl substituted thiazoles and oxazoles as highly potent and selective peroxisome proliferator-activated receptor delta agonists.
Topics: Animals; Drug Evaluation, Preclinical; Fluorescence Resonance Energy Transfer; High-Throughput Screening Assays; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Molecular Structure; Oxazoles; PPAR delta; Stereoisomerism; Structure-Activity Relationship; Thiazoles | 2010 |
Rhodium carbene routes to oxazoles and thiazoles. Catalyst effects in the synthesis of oxazole and thiazole carboxylates, phosphonates, and sulfones.
Topics: Carboxylic Acids; Catalysis; Magnetic Resonance Spectroscopy; Methane; Molecular Structure; Organophosphonates; Oxazoles; Rhodium; Stereoisomerism; Structure-Activity Relationship; Sulfones; Thiazoles | 2010 |
Synthesis and bioimmunological efficiency of poly(2-oxazolines) containing a free amino group.
Topics: Animals; Biocompatible Materials; Cell Survival; Macrophages; Materials Testing; Mice; Oxazoles; Phagocytosis; Polymers; Polysaccharides; Proteins; Respiratory Burst; Temperature; Tetrazolium Salts; Thiazoles; Time Factors | 2010 |
Activation of peroxisome proliferator-activated receptor-beta/delta attenuates myocardial ischemia/reperfusion injury in the rat.
Topics: Animals; Cyclooxygenase 2; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hemodynamics; Male; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide Synthase Type II; Oxazoles; Phosphorylation; PPAR alpha; PPAR delta; PPAR-beta; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Thiazoles; Tyrosine | 2010 |
Phenyl-oxazoles, a new family of inverse agonists at the H(3) histamine receptor.
Topics: Animals; Benzene; Caco-2 Cells; Cell Line; Cognition Disorders; Drug Inverse Agonism; Histamine Antagonists; Humans; Male; Mice; Microsomes, Liver; Oxazoles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Histamine H3; Structure-Activity Relationship; Thiazoles | 2010 |
Catalyst-controlled regioselective Suzuki couplings at both positions of dihaloimidazoles, dihalooxazoles, and dihalothiazoles.
Topics: Catalysis; Cross-Linking Reagents; Hydrocarbons, Halogenated; Imidazoles; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Oxazoles; Palladium; Stereoisomerism; Thiazoles | 2010 |
Adaptative biaryl phosphite-oxazole and phosphite-thiazole ligands for asymmetric Ir-catalyzed hydrogenation of alkenes.
Topics: Alkenes; Catalysis; Combinatorial Chemistry Techniques; Hydrogenation; Iridium; Ligands; Molecular Structure; Oxazoles; Phosphites; Stereoisomerism; Thiazoles | 2010 |
Synthesis and bioassay of pyrrolyl oxazolines and thiazolines.
Topics: Anti-Infective Agents; Bacteria; Biphenyl Compounds; Free Radical Scavengers; Fungi; Microbial Sensitivity Tests; Nitric Oxide; Oxazoles; Picrates; Sulfones; Thiazoles | 2010 |
Synthesis of 2-trifluoromethyl-1,3-oxazolidines as hydrolytically stable pseudoprolines.
Topics: Acylation; Esters; Fluorine; Methane; Molecular Structure; Oxazoles; Proline; Thiazoles | 2010 |
Responses in mantle cell lymphoma cells to SNS-032 depend on the biological context of each cell line.
Topics: Cell Cycle; Cell Death; Cell Growth Processes; Cell Line, Tumor; Cyclin D1; Humans; Lymphoma, Mantle-Cell; Myeloid Cell Leukemia Sequence 1 Protein; Oxazoles; Proto-Oncogene Proteins c-bcl-2; RNA, Neoplasm; RNA, Small Nuclear; Thiazoles; Transfection | 2010 |
Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers.
Topics: Animals; Dogs; Humans; Imidazoles; Microsomes, Liver; NAV1.7 Voltage-Gated Sodium Channel; Neuralgia; Oxazoles; Rats; Sodium Channel Blockers; Sodium Channels; Thiazoles | 2010 |
Chemoproteomics-based kinome profiling and target deconvolution of clinical multi-kinase inhibitors in primary chronic lymphocytic leukemia cells.
Topics: Apoptosis; Flavonoids; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Oxazoles; Piperidines; Positive Transcriptional Elongation Factor B; Protein Kinase Inhibitors; Proteomics; Thiazoles | 2011 |
Selective accumulation of a novel antimalarial rhodacyanine derivative, SSJ-127, in an organelle of Plasmodium berghei.
Topics: Animals; Antimalarials; Benzothiazoles; Erythrocytes; Mice; Microscopy, Fluorescence; Mitochondria; Oxazoles; Plasmodium berghei; Pyridinium Compounds; Rhodamine 123; Thiazoles | 2010 |
Homoharringtonine reduced Mcl-1 expression and induced apoptosis in chronic lymphocytic leukemia.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Cell Proliferation; Drug Synergism; Drug Therapy, Combination; Harringtonines; Homoharringtonine; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Middle Aged; Mitochondrial Membranes; Myeloid Cell Leukemia Sequence 1 Protein; Oxazoles; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stromal Cells; Thiazoles; Tumor Cells, Cultured | 2011 |
The cyclin-dependent kinase inhibitor SNS-032 has single agent activity in AML cells and is highly synergistic with cytarabine.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Apoptosis; Cell Cycle; Cells, Cultured; Cyclin-Dependent Kinases; Cytarabine; Drug Synergism; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Oxazoles; Phosphorylation; Thiazoles | 2011 |
Mitochondrial reactive oxygen species are activated by mGluR5 through IP3 and activate ERK and PKA to increase excitability of amygdala neurons and pain behavior.
Topics: Amygdala; Analysis of Variance; Animals; Antioxidants; Benzoates; Cyclic AMP-Dependent Protein Kinases; Cyclic N-Oxides; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Extracellular Signal-Regulated MAP Kinases; Glycine; Inositol 1,4,5-Trisphosphate; Macrocyclic Compounds; Mitochondria; Neurons; NG-Nitroarginine Methyl Ester; Oxazoles; Pain; Pain Measurement; Pain Perception; Patch-Clamp Techniques; Pyridines; Reactive Oxygen Species; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Signal Transduction; Spin Labels; Superoxides; Thiazoles; Vocalization, Animal | 2011 |
Spoxazomicins A-C, novel antitrypanosomal alkaloids produced by an endophytic actinomycete, Streptosporangium oxazolinicum K07-0460(T).
Topics: Actinobacteria; Alkaloids; Cell Line; Chromatography; Chromatography, High Pressure Liquid; Humans; Inhibitory Concentration 50; Oxazoles; Phenols; Silica Gel; Thiazoles; Trypanocidal Agents | 2011 |
Importance of porins for biocide efficacy against Mycobacterium smegmatis.
Topics: Biguanides; Disinfectants; Gene Deletion; Imines; Microbial Viability; Mycobacterium smegmatis; Oxazines; Oxazoles; Porins; Pyridines; Staining and Labeling; Thiazoles; Triazines; Xanthenes | 2011 |
Direct arylation of simple azoles catalyzed by 1,10-phenanthroline containing palladium complexes: an investigation of C4 arylation of azoles and the synthesis of triarylated azoles by sequential arylation.
Topics: Benzhydryl Compounds; Carbon; Catalysis; Imidazoles; Organometallic Compounds; Oxazoles; Palladium; Phenanthrolines; Protein Kinase Inhibitors; Receptor, TIE-2; Thiazoles | 2011 |
FvbA is required for vibriobactin utilization in Pseudomonas aeruginosa.
Topics: Bacterial Outer Membrane Proteins; Bacterial Proteins; Catechols; Gene Expression Regulation, Bacterial; Genes, Bacterial; Iron; Oligopeptides; Oxazoles; Phenols; Polymerase Chain Reaction; Pseudomonas aeruginosa; Receptors, Cell Surface; Repressor Proteins; Siderophores; Thiazoles; Vibrio cholerae | 2011 |
Synthesis and Cu(II) coordination chemistry of a patellamide derivative: consequences of the change from the natural thiazole/oxazoline to the artificial imidazole heterocycles.
Topics: Amides; Copper; Crystallography, X-Ray; Heterocyclic Compounds; Imidazoles; Models, Molecular; Molecular Conformation; Organometallic Compounds; Oxazoles; Peptides, Cyclic; Quantum Theory; Stereoisomerism; Thiazoles | 2011 |
Plantazolicin A and B: structure elucidation of ribosomally synthesized thiazole/oxazole peptides from Bacillus amyloliquefaciens FZB42.
Topics: Anti-Bacterial Agents; Bacillus; Microbial Sensitivity Tests; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oligopeptides; Oxazoles; Ribosomes; Thiazoles | 2011 |
Structure-activity relationships of phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors: investigations of various 6,5-heterocycles to improve metabolic stability.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Dogs; Drug Screening Assays, Antitumor; Female; Hepatocytes; Imidazoles; Mice; Mice, Nude; Models, Molecular; Neoplasm Transplantation; Oxazoles; Phosphoinositide-3 Kinase Inhibitors; Pyridazines; Pyridines; Rats; Structure-Activity Relationship; Sulfonamides; Thiazoles; TOR Serine-Threonine Kinases; Transplantation, Heterologous | 2011 |
Nickel-catalyzed C-H arylation of azoles with haloarenes: scope, mechanism, and applications to the synthesis of bioactive molecules.
Topics: Azoles; Benzoxazoles; Biological Products; Catalysis; Febuxostat; Nickel; Oxazoles; Pyridines; Thiazoles | 2011 |
The cysteine reaction with diacetyl under wine-like conditions: proposed mechanisms for mixed origins of 2-methylthiazole, 2-methyl-3-thiazoline, 2-methylthiazolidine, and 2,4,5-trimethyloxazole.
Topics: Acetaldehyde; Cysteine; Databases, Factual; Diacetyl; Gas Chromatography-Mass Spectrometry; Hexanones; Methylation; Models, Chemical; Oxazoles; Thiazoles; Volatile Organic Compounds; Wine | 2011 |
Peroxisome proliferator-activated receptor δ confers resistance to peroxisome proliferator-activated receptor γ-induced apoptosis in colorectal cancer cells.
Topics: Apoptosis; Caspase 3; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; DNA Fragmentation; Gene Expression; Gene Expression Regulation, Neoplastic; Gene Knockout Techniques; Humans; Inhibitor of Apoptosis Proteins; Oxazoles; PPAR delta; PPAR gamma; Survivin; Thiazoles; Tyrosine | 2012 |
Synthesis and antioxidant activity of oxazolyl/thiazolylsulfonylmethyl pyrazoles and isoxazoles.
Topics: Antioxidants; Biphenyl Compounds; Free Radicals; Isoxazoles; Nitric Oxide; Oxazoles; Picrates; Pyrazoles; Thiazoles | 2011 |
Structure determination and interception of biosynthetic intermediates for the plantazolicin class of highly discriminating antibiotics.
Topics: Amino Acid Sequence; Anti-Bacterial Agents; Bacillus; Bacillus anthracis; Bacteriocins; Molecular Sequence Data; Multigene Family; Oligopeptides; Oxazoles; Thiazoles | 2011 |
Stem cell antigen-1 deficiency enhances the chemopreventive effect of peroxisome proliferator-activated receptorγ activation.
Topics: Animals; Anticarcinogenic Agents; Antigens, Ly; Antineoplastic Agents; Cell Line, Tumor; Genetic Predisposition to Disease; Heterozygote; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Oxazoles; Phenotype; PPAR gamma; RNA Interference; Signal Transduction; Thiazoles; Tyrosine | 2012 |
Mechanism selection for regiocontrol in base-assisted, palladium-catalysed direct C-H coupling with halides: first approach for oxazole- and thiazole-4-carboxylates.
Topics: Carboxylic Acids; Catalysis; Combinatorial Chemistry Techniques; Molecular Structure; Oxazoles; Palladium; Solvents; Thiazoles | 2011 |
In silico identification of structure requirement for novel thiazole and oxazole derivatives as potent fructose 1,6-bisphosphatase inhibitors.
Topics: Computer Simulation; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Fructose-Bisphosphatase; Hydrogen Bonding; Models, Molecular; Molecular Docking Simulation; Molecular Dynamics Simulation; Oxazoles; Quantitative Structure-Activity Relationship; Sequence Alignment; Thiazoles | 2011 |
Three ring posttranslational circuses: insertion of oxazoles, thiazoles, and pyridines into protein-derived frameworks.
Topics: Histidine; Oxazoles; Proline; Protein Processing, Post-Translational; Proteins; Pyridines; Thiazoles; Tryptophan | 2012 |
Synthesis and evaluation of anti-tubercular and antibacterial activities of new 4-(2,6-dichlorobenzyloxy)phenyl thiazole, oxazole and imidazole derivatives. Part 2.
Topics: Anti-Bacterial Agents; Antitubercular Agents; Bacteria; Bacterial Infections; Humans; Imidazoles; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxazoles; Thiazoles; Tuberculosis | 2012 |
Total synthesis of trans,trans-Sanguinamide B and conformational isomers.
Topics: Isomerism; Molecular Structure; Oxazoles; Peptides, Cyclic; Pseudomonas aeruginosa; Thiazoles; Virulence | 2012 |
Generation and exploration of new classes of antitubercular agents: The optimization of oxazolines, oxazoles, thiazolines, thiazoles to imidazo[1,2-a]pyridines and isomeric 5,6-fused scaffolds.
Topics: Antitubercular Agents; Isomerism; Isoxazoles; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxazoles; Pyridines; Structure-Activity Relationship; Thiazoles | 2012 |
Selectivity, directionality, and promiscuity in peptide processing from a Bacillus sp. Al Hakam cyclodehydratase.
Topics: Bacillus thuringiensis; Hydro-Lyases; Oxazoles; Peptides; Thiazoles | 2012 |
Cyclin-dependent kinase 7/9 inhibitor SNS-032 abrogates FIP1-like-1 platelet-derived growth factor receptor α and bcr-abl oncogene addiction in malignant hematologic cells.
Topics: Animals; Apoptosis; Blotting, Western; Cell Cycle; Cell Line; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase 9; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Female; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Mice; Mice, Inbred BALB C; Mice, Nude; mRNA Cleavage and Polyadenylation Factors; Oncogene Proteins, Fusion; Oxazoles; Phosphorylation; Receptor, Platelet-Derived Growth Factor alpha; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Thiazoles; Xenograft Model Antitumor Assays | 2012 |
YcaO domains use ATP to activate amide backbones during peptide cyclodehydrations.
Topics: Adenosine Triphosphate; Amides; Amino Acid Sequence; Anti-Bacterial Agents; Bacterial Proteins; Bacteriocins; Catalytic Domain; Cyclization; Hydrolysis; Molecular Sequence Data; Multienzyme Complexes; Multigene Family; Oxazoles; Peptide Biosynthesis; Peptides, Cyclic; Phosphorylation; Substrate Specificity; Thiazoles | 2012 |
Asymmetric Friedel-Crafts alkylation of indoles with 3-nitro-2H-chromenes catalyzed by diphenylamine-linked bis(oxazoline) and bis(thiazoline) Zn(II) complexes.
Topics: Alkylation; Benzopyrans; Catalysis; Diphenylamine; Indoles; Molecular Structure; Nitro Compounds; Oxazoles; Stereoisomerism; Thiazoles; Zinc Compounds | 2012 |
Synthesis and characterization of molecules containing thiazole and oxazole moieties and study of ESIPT phenomenon.
Topics: Chemistry Techniques, Synthetic; Dimethylformamide; Models, Molecular; Molecular Conformation; Oxazoles; Protons; Quantum Theory; Solvents; Spectrometry, Fluorescence; Temperature; Thiazoles | 2012 |
Synthesis of a Microcystis aeruginosa predicted metabolite with antimalarial activity.
Topics: Antimalarials; Drug Resistance, Microbial; Microcystis; Oxazoles; Peptides, Cyclic; Plasmodium falciparum; Thiazoles | 2012 |
Multicomponent assembly of proposed DNA precursors in water.
Topics: Acetaldehyde; Cyanamide; Deoxyribonucleotides; DNA; Oxazoles; Thiazoles; Thiosugars; Water | 2012 |
Abnormal oxazol-4-ylidene and thiazol-4-ylidene rhodium complexes: synthesis, structure, and properties.
Topics: Crystallography, X-Ray; Models, Molecular; Molecular Structure; Organometallic Compounds; Oxazoles; Rhodium; Thiazoles | 2012 |
Structural analysis of cytochrome P450 105N1 involved in the biosynthesis of the zincophore, coelibactin.
Topics: Bacterial Proteins; Catalytic Domain; Crystallography, X-Ray; Cytochrome P-450 Enzyme System; Models, Molecular; Oxazoles; Protein Structure, Secondary; Siderophores; Streptomyces coelicolor; Thiazoles; Zinc | 2012 |
Synthesis, structure-activity analysis, and biological evaluation of sanguinamide B analogues.
Topics: Amino Acids; Magnetic Resonance Spectroscopy; Molecular Conformation; Oxazoles; Peptides, Cyclic; Stereoisomerism; Structure-Activity Relationship; Thiazoles | 2012 |
Discovery and optimization of a series of 2-aminothiazole-oxazoles as potent phosphoinositide 3-kinase γ inhibitors.
Topics: Animals; Class Ib Phosphatidylinositol 3-Kinase; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Discovery; High-Throughput Screening Assays; Macrophages; Mice; Models, Molecular; Molecular Structure; Oxazoles; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Structure-Activity Relationship; Thiazoles | 2012 |
Antagonistic effect of small-molecule inhibitors of Wnt/β-catenin in multiple myeloma.
Topics: Antineoplastic Agents; beta Catenin; Blotting, Western; Cell Line, Tumor; Cell Movement; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Humans; Multiple Myeloma; Oxazoles; Real-Time Polymerase Chain Reaction; Signal Transduction; Thiazoles; Transfection; Vascular Endothelial Growth Factor A; Wnt Proteins | 2012 |
Important role of PLC-γ1 in hypoxic increase in intracellular calcium in pulmonary arterial smooth muscle cells.
Topics: Animals; Boron Compounds; Calcium; Electron Transport Complex III; Estrenes; Gene Expression; Hypoxia; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Lentivirus; Macrocyclic Compounds; Methacrylates; Mice; Muscle Contraction; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oxazoles; Phospholipase C gamma; Pulmonary Artery; Pyrrolidinones; Reactive Oxygen Species; RNA, Small Interfering; Thiazoles; Vasoconstriction | 2013 |
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Caco-2 Cells; Cell Proliferation; Dogs; Drug Carriers; Humans; Madin Darby Canine Kidney Cells; Multidrug Resistance-Associated Proteins; Naphthalenes; Oxazoles; Rhodamine 123; Structure-Activity Relationship; Substrate Specificity; Thiazoles | 2013 |
SNS-032 inhibits mTORC1/mTORC2 activity in acute myeloid leukemia cells and has synergistic activity with perifosine against Akt.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Cell Proliferation; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Humans; Leukemia, Myeloid, Acute; Male; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Multiprotein Complexes; Oxazoles; Phosphorylation; Phosphorylcholine; Proto-Oncogene Proteins c-akt; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Thiazoles; TOR Serine-Threonine Kinases; Tumor Cells, Cultured | 2013 |
An enzymatic route to selenazolines.
Topics: Amino Acid Sequence; Cysteine; Iodoacetamide; Multienzyme Complexes; Oxazoles; Peptides, Cyclic; Selenium; Selenocysteine; Serine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiazoles; Threonine | 2013 |
Bromotyrosine alkaloids from the Australian marine sponge Pseudoceratina verrucosa.
Topics: Alkaloids; Animals; Australia; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Hydrocarbons, Brominated; Male; Marine Biology; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oxazoles; Porifera; Thiazoles; Tyrosine | 2013 |
DDQ-induced dehydrogenation of heterocycles for C-C double bond formation: synthesis of 2-thiazoles and 2-oxazoles.
Topics: Benzoquinones; Carbon; Catalysis; Oxazoles; Oxidation-Reduction; Thiazoles | 2013 |
Tetroazolemycins A and B, two new oxazole-thiazole siderophores from deep-sea Streptomyces olivaceus FXJ8.012.
Topics: Anti-Bacterial Agents; Diketopiperazines; Klebsiella pneumoniae; Magnetic Resonance Spectroscopy; Oceans and Seas; Oxazoles; Siderophores; Spectrum Analysis; Streptomyces; Thiazoles; Zinc | 2013 |
Insights into the mechanism of peptide cyclodehydrations achieved through the chemoenzymatic generation of amide derivatives.
Topics: Amides; Bacteriocins; Hydro-Lyases; Molecular Structure; Oxazoles; Peptides; Thiazoles | 2013 |
Single-step microwave-mediated synthesis of oxazoles and thiazoles from 3-oxetanone: a synthetic and computational study.
Topics: Carbon; Catalysis; Chalcogens; Computers, Molecular; Ethers, Cyclic; Microwaves; Oxazoles; Oxygen; Solvents; Thiazoles; Thioamides | 2013 |
Oxazolopyridines and thiazolopyridines as monoamine oxidase B inhibitors for the treatment of Parkinson's disease.
Topics: Binding Sites; Catalytic Domain; Dopamine; Humans; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxazoles; Parkinson Disease; Pyridines; Recombinant Proteins; Structure-Activity Relationship; Thiazoles | 2013 |
[Effect of SNS-032 on biological activity of hematopoietic stem cells in mice].
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Cell Cycle; Cell Cycle Proteins; Cells, Cultured; Hematopoietic Stem Cells; Mice; Mice, Inbred C57BL; Oxazoles; Thiazoles | 2013 |
Capturing linear intermediates and C-terminal variants during maturation of the thiopeptide GE2270.
Topics: Actinomycetales; Amino Acid Sequence; Anti-Bacterial Agents; Genes, Fungal; Molecular Sequence Data; Multigene Family; Oxazoles; Peptides, Cyclic; Pyridines; Thiazoles | 2013 |
Mechanistic studies of sanguinamide B derivatives: a unique inhibitor of eukaryotic ribosomes.
Topics: Apoptosis; Humans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oxazoles; Peptides, Cyclic; Proteins; Ribosomes; Thiazoles | 2013 |
Synthesis and HDAC inhibitory activity of isosteric thiazoline-oxazole largazole analogs.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Depsipeptides; Histone Deacetylase Inhibitors; Humans; Molecular Docking Simulation; Neoplasms; Oxazoles; Thiazoles | 2013 |
Synthesis of plantazolicin analogues enables dissection of ligand binding interactions of a highly selective methyltransferase.
Topics: Amino Acid Sequence; Bacteriocins; Binding Sites; Calorimetry; Ligands; Methyltransferases; Oligopeptides; Oxazoles; Thermodynamics; Thiazoles | 2013 |
Combinatorial synthesis of oxazol-thiazole bis-heterocyclic compounds.
Topics: Combinatorial Chemistry Techniques; Heterocyclic Compounds; Molecular Structure; Oxazoles; Thiazoles | 2014 |
Orchestration of enzymatic processing by thiazole/oxazole-modified microcin dehydrogenases.
Topics: Azoles; Bacillus; Bacteriocins; Molecular Structure; Oxazoles; Oxidoreductases; Thiazoles | 2014 |
Intracellular activity of tedizolid phosphate and ACH-702 versus Mycobacterium tuberculosis infected macrophages.
Topics: Antitubercular Agents; Bacterial Load; Cell Line; Humans; Macrophages; Mycobacterium tuberculosis; Organophosphates; Oxazoles; Quinolones; Thiazoles | 2014 |
The cyclin-dependent kinase inhibitor SNS-032 induces apoptosis in breast cancer cells via depletion of Mcl-1 and X-linked inhibitor of apoptosis protein and displays antitumor activity in vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Cyclin-Dependent Kinase 2; Female; Heterografts; Humans; In Situ Nick-End Labeling; Mice; Mice, Inbred BALB C; Mice, Nude; Myeloid Cell Leukemia Sequence 1 Protein; Oxazoles; Real-Time Polymerase Chain Reaction; Thiazoles; X-Linked Inhibitor of Apoptosis Protein | 2014 |
Discovery of a new ATP-binding motif involved in peptidic azoline biosynthesis.
Topics: Adenosine Triphosphate; Amino Acid Motifs; Bacteriocins; Catalytic Domain; Crystallography, X-Ray; Escherichia coli; Escherichia coli Proteins; Hydro-Lyases; Models, Molecular; Molecular Sequence Data; Oxazoles; Phosphotransferases; Protein Binding; Protein Biosynthesis; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Thiazoles; Ubiquitin-Activating Enzymes | 2014 |
Total syntheses of linear polythiazole/oxazole plantazolicin A and its biosynthetic precursor plantazolicin B.
Topics: Amino Acids; Anti-Bacterial Agents; Bacillus anthracis; Cyclization; Hydrocarbons, Fluorinated; Oligopeptides; Oxazoles; Oxidation-Reduction; Sulfur Compounds; Thiazoles | 2015 |
ΔF508-CFTR correctors: synthesis and evaluation of thiazole-tethered imidazolones, oxazoles, oxadiazoles, and thiadiazoles.
Topics: Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Humans; Imidazoles; Kinetics; Molecular Conformation; Oxadiazoles; Oxazoles; Protein Binding; Structure-Activity Relationship; Thermodynamics; Thiadiazoles; Thiazoles; Water | 2014 |
Cyclin E1 and RTK/RAS signaling drive CDK inhibitor resistance via activation of E2F and ETS.
Topics: Animals; Cyclin E; Cyclin-Dependent Kinases; Drug Resistance, Neoplasm; E2F Transcription Factors; Female; Humans; Mice; Mice, Nude; Oncogene Proteins; Ovarian Neoplasms; Oxazoles; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ets; Proto-Oncogene Proteins p21(ras); Pyridines; Random Allocation; ras Proteins; Receptor Protein-Tyrosine Kinases; Signal Transduction; Thiazoles; Transcription, Genetic; Xenograft Model Antitumor Assays | 2015 |
PCTAIRE1-knockdown sensitizes cancer cells to TNF family cytokines.
Topics: Apoptosis; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 8; Cell Line, Tumor; Cyclin-Dependent Kinases; Cytokines; Fas-Associated Death Domain Protein; HEK293 Cells; HeLa Cells; Humans; Oxazoles; Receptor-Interacting Protein Serine-Threonine Kinases; RNA Interference; RNA, Messenger; RNA, Small Interfering; Thiazoles; TNF-Related Apoptosis-Inducing Ligand | 2015 |
Interactions of cyclin-dependent kinase inhibitors AT-7519, flavopiridol and SNS-032 with ABCB1, ABCG2 and ABCC1 transporters and their potential to overcome multidrug resistance in vitro.
Topics: Animals; ATP-Binding Cassette Transporters; Cell Proliferation; Dogs; Drug Interactions; Drug Resistance, Multiple; Flavonoids; Humans; Madin Darby Canine Kidney Cells; Oxazoles; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Thiazoles | 2015 |
Identification of an Auxiliary Leader Peptide-Binding Protein Required for Azoline Formation in Ribosomal Natural Products.
Topics: Amino Acid Sequence; Bacillus; Bacterial Proteins; Bacteriocins; Biological Products; Biosynthetic Pathways; Hydro-Lyases; Molecular Sequence Data; Oxazoles; Protein Sorting Signals; Ribosomes; Thiazoles | 2015 |
[Apoptosis of acute myeloid leukemia HL-60 cells induced by CDK inhibitor SNS-032 and its molecular mechanisms].
Topics: Apoptosis; Cell Survival; Down-Regulation; Flow Cytometry; HL-60 Cells; Humans; Janus Kinase 2; MicroRNAs; Oxazoles; Phosphorylation; Signal Transduction; STAT3 Transcription Factor; Thiazoles | 2015 |
Cyclin-dependent kinase 2 is an ideal target for ovary tumors with elevated cyclin E1 expression.
Topics: Animals; Apoptosis; CDC2 Protein Kinase; Cell Line, Tumor; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Nude; Neoplasm Metastasis; Neoplasm Transplantation; Oncogene Proteins; Ovarian Neoplasms; Oxazoles; RNA, Small Interfering; Thiazoles; Triazoles | 2015 |
Discovery of a Teraryl Oxazolidinone Compound (S)-N-((3-(3-Fluoro-4-(4-(pyridin-2-yl)-1H-pyrazol-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide Phosphate as a Novel Antimicrobial Agent with Enhanced Safety Profile and Efficacies.
Topics: Acetamides; Animals; Anti-Infective Agents; Bacteria; Biological Availability; Drug Design; Ether-A-Go-Go Potassium Channels; Linezolid; Methicillin-Resistant Staphylococcus aureus; Mice; Microbial Sensitivity Tests; Models, Molecular; Oxazoles; Oxazolidinones; Potassium Channel Blockers; Staphylococcal Infections; Structure-Activity Relationship; Tetrazolium Salts; Thiazoles | 2015 |
Synthesis and antimicrobial activity of binaphthyl-based, functionalized oxazole and thiazole peptidomimetics.
Topics: Anti-Bacterial Agents; Bacteria; Bacterial Infections; Humans; Microbial Sensitivity Tests; Naphthalenes; Oxazoles; Peptidomimetics; Thiazoles | 2015 |
Palladium-Catalyzed Heteroarylation and Concomitant ortho-Alkylation of Aryl Iodides.
Topics: Alkylation; Catalysis; Hydrocarbons, Iodinated; Iodides; Molecular Structure; Organometallic Compounds; Oxazoles; Palladium; Thiazoles; Thiophenes | 2015 |
Synthesis of 2-Aminoazoles from Thioesters via α-Heterosubstituted Ketones by Copper-Mediated Cross-Coupling.
Topics: Azoles; Copper; Esters; Imidazoles; Ketones; Molecular Structure; Oxazoles; Sulfhydryl Compounds; Thiazoles | 2015 |
Non-target effects of commonly used plant protection products in roses on the predatory mite Euseius gallicus Kreiter & Tixier (Acari: Phytoseidae).
Topics: Acaricides; Acetates; Animals; Fungicides, Industrial; Imidazoles; Limonins; Mites; Naphthalenes; Neonicotinoids; Niacinamide; Nitro Compounds; Oxazines; Oxazoles; Pyridines; Rosa; Thiamethoxam; Thiazines; Thiazoles | 2016 |
The genomic landscape of ribosomal peptides containing thiazole and oxazole heterocycles.
Topics: Biosynthetic Pathways; Computational Biology; Genomics; Multigene Family; Oxazoles; Peptides; Phylogeny; Protein Processing, Post-Translational; Protein Structure, Tertiary; Ribosomal Proteins; Ribosomes; Thiazoles | 2015 |
Immuno-modulating properties of saliphenylhalamide, SNS-032, obatoclax, and gemcitabine.
Topics: Amides; Antineoplastic Agents; Antiviral Agents; Cells, Cultured; Coinfection; Cytokines; Deoxycytidine; Gemcitabine; Humans; Immunity, Innate; Immunologic Factors; Indoles; Influenza A virus; Influenza, Human; Interferon-alpha; Lipopolysaccharides; Macrophages; Oxazoles; Phosphoproteins; Pyrroles; RNA, Viral; Salicylates; Thiazoles; Virus Replication | 2016 |
Efficient Synthesis and Antibacterial Evaluation of (±)-Yanglingmycin and Its Analogues.
Topics: Anti-Bacterial Agents; Gram-Negative Bacteria; Gram-Positive Bacteria; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Oxazoles; Structure-Activity Relationship; Thiazoles | 2016 |
Synthesis of Canthardin Sulfanilamides and Their Acid Anhydride Analogues via a Ring-Opening Reaction of Activated Aziridines and Their Associated Pharmacological Effects.
Topics: Anhydrides; Antineoplastic Agents; Aziridines; Cantharidin; Cell Line, Tumor; Cell Survival; HL-60 Cells; Humans; Inhibitory Concentration 50; MCF-7 Cells; Oxazoles; Pyrazoles; Pyrimidines; Structure-Activity Relationship; Sulfanilamides; Thiazoles | 2016 |
Conformational transformation of ascidiacyclamide analogues induced by incorporating enantiomers of phenylalanine, 1-naphthylalanine or 2-naphthylalanine.
Topics: Alanine; Cell Survival; Crystallography, X-Ray; Cytotoxins; HL-60 Cells; Humans; Models, Molecular; Naphthalenes; Oxazoles; Peptides, Cyclic; Phenylalanine; Protein Conformation; Protein Folding; Stereoisomerism; Structure-Activity Relationship; Thiazoles | 2016 |
Selective inhibition of the kinase DYRK1A by targeting its folding process.
Topics: Amino Acid Sequence; Animals; Biological Assay; Biomarkers; Cantharidin; Dyrk Kinases; Embryo, Nonmammalian; Gene Expression Regulation, Developmental; HEK293 Cells; Humans; Marine Toxins; Molecular Sequence Data; Okadaic Acid; Oxazoles; Phosphorylation; Plasmids; Protein Folding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Recombinant Proteins; Sequence Alignment; Thiazoles; Transfection; Xenopus laevis | 2016 |
2-Aminoxazole and 2-Aminothiazole Dasatinib Derivatives as Potent Inhibitors of Chronic Myeloid Leukemia K562 Cells.
Topics: Cell Line, Tumor; Cell Proliferation; Dasatinib; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Oxazoles; Structure-Activity Relationship; Thiazoles | 2016 |
Replacement of Oxygen by Sulfur in Small Organic Molecules. 3. Theoretical Studies on the Tautomeric Equilibria of the 2OH and 4OH-Substituted Oxazole and Thiazole and the 3OH and 4OH-Substituted Isoxazole and Isothiazole in the Isolated State and in Solu
Topics: Isomerism; Isoxazoles; Models, Theoretical; Oxazoles; Solutions; Sulfur; Thermodynamics; Thiazoles | 2016 |
ABCB1 as predominant resistance mechanism in cells with acquired SNS-032 resistance.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cell Line, Tumor; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 9; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Drug Resistance, Neoplasm; Humans; Inhibitory Concentration 50; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Neuroblastoma; Oxazoles; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; RNA Interference; RNA, Small Interfering; Sulfonamides; Thiazoles | 2016 |
Characterization of the Mouse and Human Monoacylglycerol O-Acyltransferase 1 (Mogat1) Promoter in Human Kidney Proximal Tubule and Rat Liver Cells.
Topics: Acyltransferases; Anilides; Animals; Blotting, Northern; Caco-2 Cells; Cell Line; Cell Line, Tumor; Chromatin Immunoprecipitation; Computational Biology; HT29 Cells; Humans; Kidney Tubules, Proximal; Liver; Mice; Oxazoles; PPAR alpha; Promoter Regions, Genetic; Pyrimidines; Rats; Real-Time Polymerase Chain Reaction; Rosiglitazone; Sulfones; Thiazoles; Thiazolidinediones; Thiophenes; Tyrosine | 2016 |
The Total Synthesis of the Bioactive Natural Product Plantazolicin A and Its Biosynthetic Precursor Plantazolicin B.
Topics: Biological Products; Oligopeptides; Oxazoles; Oxidation-Reduction; Thiazoles | 2016 |
Designing, synthesis, and antimicrobial action of oxazoline and thiazoline derivatives of fatty acid esters.
Topics: Anti-Bacterial Agents; Antifungal Agents; Disk Diffusion Antimicrobial Tests; Esters; Humans; Intestinal Absorption; Klebsiella pneumoniae; Molecular Docking Simulation; Oxazoles; Pseudomonas aeruginosa; Staphylococcus aureus; Streptococcus pyogenes; Thiazoles | 2017 |
Regulation of kynurenine biosynthesis during influenza virus infection.
Topics: Animals; Antiviral Agents; Female; Gene Expression Regulation; Host-Pathogen Interactions; Humans; Immunologic Factors; Indoleamine-Pyrrole 2,3,-Dioxygenase; Indoles; Influenza A Virus, H1N1 Subtype; Interferons; Kynurenine; Lung; Macrophages; Metabolic Networks and Pathways; Mice; Mice, Inbred BALB C; Orthomyxoviridae Infections; Oxazoles; Oximes; Primary Cell Culture; Pyrroles; Sulfonamides; Thiazoles; Transcriptome; Tryptophan; Viral Nonstructural Proteins; Virus Replication | 2017 |
Synthesis and antimycobacterial screening of new thiazolyl-oxazole derivatives.
Topics: Anti-Bacterial Agents; Antitubercular Agents; Cell Line; Cell Line, Tumor; Humans; Microbial Sensitivity Tests; Mycobacterium; Oxazoles; Thiazoles | 2017 |
Synergistic antitumor effects of CDK inhibitor SNS‑032 and an oncolytic adenovirus co‑expressing TRAIL and Smac in pancreatic cancer.
Topics: Adenoviridae; Animals; Apoptosis; Apoptosis Regulatory Proteins; Cell Cycle Checkpoints; Cell Line, Tumor; Combined Modality Therapy; Disease Models, Animal; Gene Expression; Genetic Therapy; Genetic Vectors; Humans; Intracellular Signaling Peptides and Proteins; Male; Mice; Mitochondrial Proteins; Oncolytic Virotherapy; Oncolytic Viruses; Oxazoles; Pancreatic Neoplasms; Signal Transduction; Thiazoles; TNF-Related Apoptosis-Inducing Ligand; Xenograft Model Antitumor Assays | 2017 |
6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]thiazoles: Facile synthesis and comparative appraisal against tuberculosis and neglected tropical diseases.
Topics: Animals; Antitubercular Agents; Chagas Disease; Disease Models, Animal; Mice; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Nitroimidazoles; Oxazoles; Structure-Activity Relationship; Thiazoles; Tuberculosis | 2017 |
Mechanistic Insight Leads to a Ligand Which Facilitates the Palladium-Catalyzed Formation of 2-(Hetero)Arylaminooxazoles and 4-(Hetero)Arylaminothiazoles.
Topics: Catalysis; Ligands; Molecular Structure; Organometallic Compounds; Oxazoles; Palladium; Thiazoles | 2017 |
Screening of the 'Stasis Box' identifies two kinase inhibitors under pharmaceutical development with activity against Haemonchus contortus.
Topics: Amino Acid Sequence; Animals; Antinematodal Agents; Cell Line; Dose-Response Relationship, Drug; Haemonchiasis; Haemonchus; Humans; Larva; Models, Molecular; Oxazoles; Protein Kinase Inhibitors; Sequence Alignment; Small Molecule Libraries; Thiazoles; Tyrphostins | 2017 |
Study of the interactions between Edaglitazone and Ciglitazone with PPARγ and their antiplatelet profile.
Topics: Binding Sites; Blood Platelets; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Healthy Volunteers; Humans; Ligands; Molecular Docking Simulation; Molecular Structure; Oxazoles; Platelet Aggregation; Platelet Aggregation Inhibitors; PPAR gamma; Protein Binding; Thiazoles; Thiazolidinediones | 2017 |
Discovery of novel drug sensitivities in T-PLL by high-throughput ex vivo drug testing and mutation profiling.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Biomarkers, Tumor; Cell Cycle; Cell Line, Tumor; Chromosome Aberrations; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Gene Expression; Gene Expression Profiling; High-Throughput Screening Assays; Humans; Janus Kinases; Leukemia, Prolymphocytic, T-Cell; Male; Middle Aged; Molecular Targeted Therapy; Mutation; Oxazoles; Phenotype; Protein Kinase Inhibitors; STAT Transcription Factors; Thiazoles | 2018 |
Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation.
Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Cyclin-Dependent Kinase 9; Humans; Inhibitory Concentration 50; Ligands; Oxazoles; Peptide Hydrolases; Phosphorylation; Protein Binding; Protein Conformation; Protein Kinase Inhibitors; Proteomics; Thalidomide; Thiazoles; Ubiquitin-Protein Ligases | 2018 |
Design, synthesis, DFT study and antifungal activity of the derivatives of pyrazolecarboxamide containing thiazole or oxazole ring.
Topics: Antifungal Agents; Fungi; Models, Chemical; Models, Theoretical; Molecular Docking Simulation; Oxazoles; Pyrazoles; Structure-Activity Relationship; Thiazoles | 2018 |
Facile one-pot multicomponent synthesis and molecular docking studies of steroidal oxazole/thiazole derivatives with effective antimicrobial, antibiofilm and hemolytic properties.
Topics: Animals; Anti-Infective Agents; Biofilms; Chemistry Techniques, Synthetic; DNA Gyrase; Hemolysis; Microbial Sensitivity Tests; Molecular Docking Simulation; Oxazoles; Rabbits; Steroids; Thiazoles | 2018 |
Oxazole and thiazole analogs of sulindac for cancer prevention.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Cell Line, Tumor; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Drug Design; Drug Screening Assays, Antitumor; Female; Heterografts; Humans; Male; Neoplasms; Oxazoles; Proton Magnetic Resonance Spectroscopy; Spectrometry, Mass, Electrospray Ionization; Sulindac; Thiazoles | 2018 |
Density Functional Theory Applied to Excited State Intramolecular Proton Transfer in Imidazole-, Oxazole-, and Thiazole-Based Systems.
Topics: Hydrogen Bonding; Imidazoles; Ketones; Light; Models, Molecular; Nitrogen; Oxazoles; Photochemical Processes; Protons; Thermodynamics; Thiazoles | 2018 |
Anticancer and radiosensitizing effects of the cyclin-dependent kinase inhibitors, AT7519 and SNS‑032, on cervical cancer.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinases; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Lung Neoplasms; Mice; Oxazoles; Piperidines; Pyrazoles; Radiation-Sensitizing Agents; Thiazoles; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays | 2018 |
Drug-based perturbation screen uncovers synergistic drug combinations in Burkitt lymphoma.
Topics: Acetanilides; Agammaglobulinaemia Tyrosine Kinase; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Burkitt Lymphoma; Cell Line, Tumor; Drug Combinations; Drug Synergism; Heterocyclic Compounds, 3-Ring; Humans; Oxazoles; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Sulfonamides; Thiazoles | 2018 |
Syntheses of Cyclopropyl Analogues of Disorazoles A
Topics: Catalysis; Copper; Macrolides; Molecular Structure; Oxazoles; Palladium; Stereoisomerism; Structure-Activity Relationship; Thiazoles | 2018 |
Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPARγ.
Topics: Binding Sites; Crystallography, X-Ray; Fatty Acids; Humans; Ligands; Molecular Dynamics Simulation; Molecular Structure; Oxazoles; PPAR gamma; Protein Binding; Protein Conformation; Thiazoles; Thiazolidinediones | 2018 |
Singlet Oxygen Photooxidation of Peptidic Oxazoles and Thiazoles.
Topics: Kinetics; Oxazoles; Oxidation-Reduction; Peptides; Peptides, Cyclic; Photochemical Processes; Singlet Oxygen; Thiazoles; Valine | 2019 |
Building upon Nature's Framework: Overview of Key Strategies Toward Increasing Drug-Like Properties of Natural Product Cyclopeptides and Macrocycles.
Topics: Anthraquinones; Biological Availability; Biological Products; Chemistry, Pharmaceutical; Cyclosporine; Cyclotides; Daptomycin; Depsipeptides; Drug Design; Drug Discovery; Ethers, Cyclic; Gramicidin; Lipopeptides; Macrocyclic Compounds; Macrolides; omega-Conotoxins; Organophosphorus Compounds; Oxazoles; Peptides; Peptides, Cyclic; Thiazoles; Thiazolidines | 2019 |
Optimization, Structure-Activity Relationship, and Mode of Action of Nortopsentin Analogues Containing Thiazole and Oxazole Moieties.
Topics: Alternaria; Antiviral Agents; Drug Design; Fungicides, Industrial; Oxazoles; Structure-Activity Relationship; Thiazoles; Tobacco Mosaic Virus | 2019 |
In Vitro Biosynthesis of Peptides Containing Exotic Azoline Analogues.
Topics: Hydro-Lyases; Molecular Conformation; Oxazoles; Peptide Biosynthesis; Peptides; Protein Processing, Post-Translational; Thiazoles | 2020 |
Transcriptional inhibition by CDK7/9 inhibitor SNS-032 abrogates oncogene addiction and reduces liver metastasis in uveal melanoma.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Cell Cycle Proteins; Cell Line, Tumor; Cyclin-Dependent Kinase 9; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; Kruppel-Like Factor 4; Liver Neoplasms; Male; Melanoma; Mice; Oncogene Addiction; Oxazoles; Signal Transduction; Thiazoles; Transcription Factors; Uveal Neoplasms; Xenograft Model Antitumor Assays | 2019 |
New triazinoindole bearing thiazole/oxazole analogues: Synthesis, α-amylase inhibitory potential and molecular docking study.
Topics: alpha-Amylases; Dose-Response Relationship, Drug; Glycoside Hydrolase Inhibitors; Humans; Molecular Docking Simulation; Molecular Structure; Oxazoles; Structure-Activity Relationship; Thiazoles; Triazines | 2019 |
Solvent-Induced Protein Precipitation for Drug Target Discovery on the Proteomic Scale.
Topics: Acetic Acid; Acetone; Cells, Cultured; Drug Discovery; Drug Evaluation, Preclinical; Ethanol; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; HSP90 Heat-Shock Proteins; Humans; Methotrexate; NADH Dehydrogenase; Oxazoles; Proteomics; Solvents; Staurosporine; Thiazoles | 2020 |
Design, synthesis and biological evaluation of novel Pseudomonas aeruginosa DNA gyrase B inhibitors.
Topics: Anti-Bacterial Agents; Bacterial Proteins; DNA Gyrase; Drug Design; Humans; Models, Molecular; Oxazoles; Pseudomonas aeruginosa; Pseudomonas Infections; Thiazoles; Topoisomerase II Inhibitors | 2020 |
Exploration of certain 1,3-oxazole- and 1,3-thiazole-based hydroxamic acids as histone deacetylase inhibitors and antitumor agents.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Drug Screening Assays, Antitumor; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Molecular Docking Simulation; Oxazoles; Spectrum Analysis; Structure-Activity Relationship; Thiazoles | 2020 |
Diradicalar Character and Ring Stability of Mesoionic Heterocyclic Oxazoles and Thiazoles by Ab Initio Mono and Multi-Reference Methods.
Topics: Dimethyl Sulfoxide; Heterocyclic Compounds; Ions; Models, Molecular; Oxazoles; Solvents; Static Electricity; Thermodynamics; Thiazoles | 2020 |
Pharmacophore modeling, design, and synthesis of potent antihypertensives, oxazolo/thiazolo-[3,2-a]-pyrimidin-3(2H)-one, and 1,5-dihydroimidazo-[1,2-a]-pyrimidin-3(2H)-one derivatives: A pilot trial.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Drug Design; Female; Imidazoles; Male; Molecular Structure; Nifedipine; Oxazoles; Pilot Projects; Pyrimidines; Rats, Wistar; Structure-Activity Relationship; Thiazoles | 2020 |
Synthesis of GluN2A-selective NMDA receptor antagonists with an electron-rich aromatic B-ring.
Topics: Allosteric Site; Animals; Electrons; Electrophysiological Phenomena; Humans; Isoxazoles; Ligands; Oocytes; Oxazoles; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Sulfonamides; Thiazoles; Xenopus laevis | 2021 |
Comparison of PPAR Ligands as Modulators of Resolution of Inflammation, via Their Influence on Cytokines and Oxylipins Release in Astrocytes.
Topics: Anilides; Animals; Anti-Inflammatory Agents; Astrocytes; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Fenofibrate; Interleukin-10; Lipopolysaccharides; MAP Kinase Kinase 4; Oxazoles; Oxylipins; p38 Mitogen-Activated Protein Kinases; PPAR gamma; PPAR-beta; Rats; Rats, Wistar; Rosiglitazone; Thiazoles; Tumor Necrosis Factor-alpha; Tyrosine | 2020 |
Synthesis, anti-inflammatory and analgesic evaluation of thiazole/oxazole substituted benzothiazole derivatives.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Benzothiazoles; Edema; Mice; Molecular Conformation; Oxazoles; Pain; Rats; Structure-Activity Relationship; Thiazoles | 2021 |
Discovery of selective fragment-sized immunoproteasome inhibitors.
Topics: Drug Evaluation, Preclinical; Humans; Inhibitory Concentration 50; Oxazoles; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Subunits; Structure-Activity Relationship; Thiazoles; Thiones | 2021 |
Anti-inflammatory effects of a novel phosphodiesterase-4 inhibitor, AA6216, in mouse dermatitis models.
Topics: Animals; Anti-Inflammatory Agents; Boron Compounds; Bridged Bicyclo Compounds, Heterocyclic; Dermatitis, Atopic; Dermatophagoides farinae; Disease Models, Animal; Female; Humans; Leukocytes, Mononuclear; Mice; Oxazoles; Oxazolone; Phosphodiesterase 4 Inhibitors; Piperazines; Severity of Illness Index; Skin; Thiazoles | 2021 |
Semicarbazones, thiosemicarbazone, thiazole and oxazole analogues as monoamine oxidase inhibitors: Synthesis, characterization, biological evaluation, molecular docking, and kinetic studies.
Topics: Dose-Response Relationship, Drug; Humans; Kinetics; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxazoles; Semicarbazones; Structure-Activity Relationship; Thiazoles; Thiosemicarbazones | 2021 |
Transcriptional inhibition by CDK7/9 inhibitor SNS-032 suppresses tumor growth and metastasis in esophageal squamous cell carcinoma.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cisplatin; Cyclin-Dependent Kinase 9; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Drug Synergism; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Gene Expression Regulation, Neoplastic; Humans; Mice, Inbred BALB C; Mice, Nude; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Invasiveness; Neoplasm Metastasis; Oxazoles; Thiazoles; Transcription, Genetic; Tumor Burden; Wound Healing | 2021 |
Cyclin-dependent kinase 7/9 inhibitor SNS-032 induces apoptosis in diffuse large B-cell lymphoma cells.
Topics: Animals; Apoptosis; Cyclin-Dependent Kinases; Humans; Lymphoma, Large B-Cell, Diffuse; Mice; Mice, Nude; Neoplasm Recurrence, Local; Oxazoles; Thiazoles | 2022 |
Extending the Structure-Activity Relationship of Disorazole C
Topics: Antineoplastic Agents; Oxazoles; Structure-Activity Relationship; Thiazoles | 2022 |
Thieno-Thiazolostilbenes, Thienobenzo-Thiazoles, and Naphtho-Oxazoles: Computational Study and Cholinesterase Inhibitory Activity.
Topics: Acetylcholinesterase; Butyrylcholinesterase; Cholinesterase Inhibitors; Molecular Docking Simulation; Oxazoles; Structure-Activity Relationship; Thiazoles | 2023 |