thiazoles has been researched along with oxadiazoles in 87 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (14.94) | 18.7374 |
| 1990's | 8 (9.20) | 18.2507 |
| 2000's | 19 (21.84) | 29.6817 |
| 2010's | 40 (45.98) | 24.3611 |
| 2020's | 7 (8.05) | 2.80 |
| Authors | Studies |
|---|---|
| Craig, JW; Reed, SE; Tyrrell, DA | 1 |
| Cheng, CC; Daves, GD | 1 |
| Cesur, N; Cesur, Z; Gürsoy, A | 1 |
| Aboul Wafa, OM; Berto, FA | 1 |
| Glossmann, H; Knaus, HG; Staudinger, R | 1 |
| Blaney, FE; Brown, F; Clark, MS; Hadley, MS; Hatcher, J; Orlek, BS; Riley, GJ; Rosenberg, HE; Wadsworth, HJ; Wyman, P | 1 |
| Bonnafous, M; Bories, C; Caujolle, R; Gayral, P; Loiseau, PM; Loiseau, PR; Payard, M | 1 |
| Ferry, DR; Glossmann, H; Goll, A; Linn, T | 1 |
| Akerman, KE; Enkvist, MO; Holopainen, I | 1 |
| Krácmar, J; Krácmarová, J | 1 |
| Katz, N; Pellegrino, J | 1 |
| Bolt, AG; Ghosh, PB | 1 |
| Kier, LB; Roche, EB | 1 |
| Ghosh, PB; Whitehouse, MW | 1 |
| Saikawa, I; Takai, A | 1 |
| Amico-Roxas, M; Caruso, A; Cutuli, V; Di Pietro, E; Modica, M; Russo, F; Santagati, A; Santagati, M | 1 |
| Farkas, I; Mahmoud, SH; Somsák, L | 1 |
| Ateş, O; Ekinci, AC; Kocabalkanli, A; Saniş, GO; Vidin, A | 1 |
| Hirayama, R; Kurosaki, E; Nakano, R; Shibasaki, M; Shikama, H; Shimaya, A | 1 |
| Aguirre-Bañuelos, P; Granados-Soto, V | 1 |
| Gunawan, I; Malamas, MS; McCaleb, M; Mihan, B; Sredy, J; Sullivan, D | 1 |
| Ellingboe, J; Han, S; Hu, B; Largis, E; Malamas, M; Mulvey, R; Tillett, J | 1 |
| Dalvie, DK; Kalgutkar, AS; Khojasteh-Bakht, SC; O'Donnell, JP; Obach, RS | 1 |
| Yamanouchi, T | 1 |
| Ida, M; Kurosaki, E; Nakano, R; Shibasaki, M; Shikama, H; Shimaya, A; Suzuki, T; Yoshida, S | 1 |
| HOEKFELT, B; JOENSSON, A | 1 |
| ADAMS, AC; BLUMENTHAL, A; O'NEAL, JB; ROSEN, H; RUSSELL, PB | 1 |
| BALLONOFF, LB; FEINSTEIN, RN; SEAHOLM, JE | 1 |
| Day, RM; Fanburg, BL; Liu, Y; Suzuki, YJ | 1 |
| Bischler, N; Chrysina, ED; Docsa, T; Gergely, P; Hadady, Z; Kardakaris, R; Kosmopoulou, MN; Leonidas, DD; Oikonomakos, NG; Somsak, L; Tiraidis, C | 1 |
| Bharatam, PV; Khanna, S; Sobhia, ME | 1 |
| Alderete, JB; Alves, RB; Cruz, AF; De Souza, AO; Pedrosa, MT; Prado, MA; Silva, CL | 1 |
| Chan, SL; Chan, SS; Fiscus, RR; Fraser, M; Tsang, BK | 1 |
| Jarajapu, YP; Knot, HJ; Oomen, C; Uteshev, VV | 1 |
| Kaller, MR; Liu, G; Magal, E; Nguyen, TT; Norman, MH; Osslund, TD; Powers, D; Rzasa, RM; Santora, VJ; Viswanadhan, VN; Wang, HL; Xiong, X; Zhong, W | 1 |
| Chhibber, M; Gupta, S; Sinha, S; Surolia, A | 1 |
| Chang, DI; Hwang, SJ; Kim, SH; Koh, SH; Yoo, AR | 1 |
| Follis, AV; Hammoudeh, DI; Metallo, SJ; Prochownik, EV; Wang, H | 1 |
| Araújo, IG; Athayde-Filho, P; Cavalcante, KV; Correia, Nde A; Dias, KL; Lira, BF; Medeiros, IA; Silva, DF; Silva-Filho, JC | 1 |
| Black, C; Chan, CC; Crane, S; Guay, J; Guiral, S; Huang, Z; Li, CS; Oballa, R; Ramtohul, YK; Xu, LJ; Zhang, L | 1 |
| Chandrashekar, SM; Kistayya, C; Mallikarjuna, BP; Rajendraprasad, Y; Suresh Kumar, GV | 1 |
| Kito, Y; Suzuki, H | 1 |
| Bordón, C; Hencken, CP; Jones-Brando, L; Mott, BT; Posner, GH; Stohler, R; Woodard, LE; Yolken, R | 1 |
| Beumer, JH; Clausen, DM; Egorin, MJ; Eiseman, JL; Guo, J; Lazo, JS; Parise, RA; Prochownik, EV | 1 |
| Bao, L; Fan, Z; Liu, X; Ma, L; Mi, N; Shi, Z; Zhang, H; Zheng, Q; Zuo, X | 1 |
| Mukherjee, AB; Sarkar, C; Zhang, Z | 1 |
| Bawa, S; Chawla, G; Kumar, J; Kumar, U | 1 |
| Adel, S; Badria, FA; Bondock, S; Etman, HA | 1 |
| Hussar, DA | 1 |
| Belavagi, NS; Gong, YD; Kalashetti, MB; Khan, AY; Khazi, IA; Mohammed Iqbal, AK | 1 |
| García, M; López, C; Martín, ML; Morán, A; Restrepo, B; San Román, L | 1 |
| Arvidsson, PI; Rosqvist, S; Söderman, P; Svensson, M; Yngve, U | 1 |
| Bauer, Y; Bolli, MH; Gatfield, J; Killer, N; Menyhart, K; Nayler, O; Renault, B; Sobel, K; Steiner, B; Studer, R | 1 |
| Aiub, CA; Araújo, JS; Batista, Dda G; Batista, MM; Britto, C; da Silva, CF; da Silva, PB; de Souza, EM; Hargrove, TY; Kim, K; Lepesheva, GI; Lionel, J; Pavão, BP; Soeiro, Mde N; Sulikowski, G; Waterman, MR | 1 |
| Bhatt, N; Desai, NC; Somani, H; Trivedi, A | 1 |
| Endo, M; Fujii, Y; Fujita, K; Inoue, T; Kimura, K; Kuroda, S; Ohtake, H; Oi, T; Oka, Y; Sekiguchi, Y; Taguchi, K; Wakahara, S; Yabuuchi, T | 1 |
| Biswas, S; Field, HJ; Sukla, S | 1 |
| Arban, R; Cavallini, P; Davies, CH; Davis, TG; Gray, FA; Montanari, D; Negri, M; Poffe, A; Rutter, AR; Schneck, J; Vicentini, E; Wren, PB | 1 |
| Raboisson, P; Swedberg, MD | 1 |
| Bieberich, E; Bryant, L; Chen, C; Chen, Z; Cuzzocrea, S; Doyle, T; Esposito, E; Janes, K; Kamocki, K; Li, C; Little, JW; Neumann, WL; Nicol, G; Obeid, L; Petrache, I; Salvemini, D; Snider, A | 1 |
| Bister, K; Hart, JR; Hartl, M; Janda, KD; Raffeiner, P; Röck, R; Schraffl, A; Stefan, E; Vogt, PK | 1 |
| Green, AL; Hsu, JH; Hubbell-Engler, B; Jones, K; Knoff, DS; Kung, AL; Ligon, KL; Maire, CL; McCauley, D; Perry, JA; Ramkissoon, LA; Ramkissoon, SH; Shacham, S | 1 |
| El-Badri, F; Hu, B; Hudson, BM; Kurth, MJ; Phuan, PW; Tantillo, DJ; Verkman, AS; Ye, L | 1 |
| Acosta, EP; James, SH; Larson, KB; Prichard, MN | 1 |
| Cominetti, D; De Cesare, M; Deraco, M; Doldi, V; Friedlander, S; Gandellini, P; Kauffman, MG; Landesman, Y; Lopergolo, A; Pennati, M; Shacham, S; Zaffaroni, N | 1 |
| Dalley, JW; Isherwood, SN; Nicholson, JR; Pekcec, A; Robbins, TW | 1 |
| Choi, JM; Im, JH; Jun, DW; Kang, KW; Kim, HS; Kim, JW; Kim, SK; Lee, K; Lim, SC; Yang, JW | 1 |
| Agut, H; Boutolleau, D; Brunet, C; Burrel, S; Collot, M; Rouard, C | 1 |
| Birkmann, A; Zimmermann, H | 1 |
| Bajorath, J; Furtmann, N; Hameed, A; Ibrar, A; Iqbal, J; Khan, I; Saeed, A; Tehseen, Y | 1 |
| Aboukameel, A; Azmi, AS; Baloglu, E; Bhutani, D; Carlson, R; Elloul, S; Kauffman, M; Mohammad, RM; Muqbil, I; Senapedis, W; Shacham, S; Zonder, J | 1 |
| Bahirat, UA; Goel, RN; Nemmani, KV; Shenoy, RR | 1 |
| Chaudhry, BZ; Cohen, JA; Conway, DS | 1 |
| Abdelghany, TM; Elkabbany, AH; Ghiaty, A; Hagras, M; Hegazy, YA; Mayhoub, AS; Mohammad, H; Seleem, MN | 1 |
| Shiraki, K | 1 |
| Araniciu, C; Ionuț, I; Marc, G; Oniga, O; Oniga, S; Stoica, CI; Tiperciuc, B; Vlase, L | 1 |
| Bhatt, P; Jha, A; Kumar, M | 1 |
| Chiba, K; Ishimoto, Y; Matsumoto, K; Takahashi, K; Tanaka, N; Watanabe, A; Yoshitomi, T | 1 |
| Bar-Or, A; Filippi, M; Piehl, F; Preziosa, P; Rocca, MA; Solari, A; Vukusic, S | 1 |
| An, YJ; Choi, SY; Im, JH; Jeong, BH; Kang, KW; Kim, SY; Kim, YG; Lee, JS; Park, S | 1 |
| Abutaleb, NS; Hagras, M; Kotb, A; Mayhoub, AS; Salama, EA; Sayed, AM; Seleem, MN | 1 |
| Jin, L; Lu, H; Wang, L; Zhou, X | 1 |
| Albers, M; Cummings, MD; Edwards, JP; Fourie, AM; Gege, C; Goldberg, SD; Hoffmann, T; Kinzel, O; Kleymann, G; Leonard, KA; Schlüter, T; Schulz, A; Scott, B; Steeneck, C; Xue, X | 1 |
| Mickevičiūtė, E; Sapijanskaitė-Banevič, B; Šiugždaitė, J; Šovkovaja, B; Vaickelionienė, R | 1 |
| Cohen, JA; McGinley, MP | 1 |
| Cao, Z; Cui, Y; Yang, J; Yang, Y; Zhai, X; Zhao, T; Zuo, D | 1 |
| Maalik, A; Mumtaz, A; Naseem, M; Perveen, F; Rafique, H; Riaz, T; Saeed, A; Sharif, M | 1 |
12 review(s) available for thiazoles and oxadiazoles
| Article | Year |
|---|---|
The chemistry and biochemistry of C-nucleosides.
Topics: Animals; Anti-Bacterial Agents; Benzimidazoles; Chemical Phenomena; Chemistry; Formycins; Imidazoles; Isoxazoles; Nucleosides; Oxadiazoles; Pseudouridine; Purine Nucleosides; Pyrazoles; Showdomycin; Thiazoles; Triazoles; Uridine | 1976 |
Experimental chemotherapy of Schistosomiasis mansoni.
Topics: Administration, Oral; Animals; Antimony; Chemosterilants; Child; Cricetinae; Cysteine; Drug Evaluation; Drug Evaluation, Preclinical; Ethylenediamines; Haplorhini; Humans; Injections, Intramuscular; Mice; Nitro Compounds; Nitrofurans; Oxadiazoles; Propylamines; Pyrimidines; Pyrroles; Quinolines; Ribonucleosides; Schistosoma mansoni; Schistosomiasis; Schistosomicides; Thiazoles; Thioxanthenes; Trypsin Inhibitors; Vinyl Compounds | 1974 |
Medicinal chemistry of the mesoionic compounds.
Topics: Chemical Phenomena; Chemistry; Oxadiazoles; Thiazoles | 1967 |
Biotransformation reactions of five-membered aromatic heterocyclic rings.
Topics: Animals; Cytochrome P-450 Enzyme System; Furans; Heterocyclic Compounds, 4 or More Rings; Humans; Imidazoles; Indoles; Isoxazoles; Models, Chemical; Molecular Structure; Oxadiazoles; Oxazoles; Pyrazoles; Pyrroles; Tetrazoles; Thiadiazoles; Thiazoles; Thiophenes; Triazoles; Xenobiotics | 2002 |
[Chemical structures and pharmacological characteristics of novel non-thiazolidinedione insulin sensitizer (JTT-501, FK614)].
Topics: Animals; Blood Glucose; Drug Design; Humans; Hypoglycemic Agents; Insulin Resistance; Isoxazoles; Lipid Metabolism; Oxadiazoles; Receptor, Insulin; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors | 2002 |
Helicase-primase inhibitors for herpes simplex virus: looking to the future of non-nucleoside inhibitors for treating herpes virus infections.
Topics: Antiviral Agents; DNA Helicases; DNA Primase; DNA Replication; Herpes Simplex; Humans; Oxadiazoles; Pyridines; Simplexvirus; Sulfonamides; Thiazoles; Viral Proteins | 2014 |
Helicase-primase as a target of new therapies for herpes simplex virus infections.
Topics: Acyclovir; Animals; Antiviral Agents; DNA Helicases; DNA Primase; Drug Design; Drug Resistance, Viral; Herpes Simplex; Humans; Molecular Targeted Therapy; Oxadiazoles; Pyridines; Sulfonamides; Thiazoles; Viral Proteins | 2015 |
HSV antivirals - current and future treatment options.
Topics: Acyclovir; Antiviral Agents; Clinical Trials, Phase II as Topic; DNA Helicases; DNA Primase; Drug Resistance, Viral; Herpes Genitalis; Herpes Simplex; Herpes Simplex Virus Vaccines; Herpesvirus 1, Human; Herpesvirus 2, Human; Humans; Oxadiazoles; Pyridines; Sulfonamides; Thiazoles; Viral Proteins | 2016 |
Sphingosine 1-Phosphate Receptor Modulators for the Treatment of Multiple Sclerosis.
Topics: Animals; Azetidines; Benzyl Compounds; Clinical Trials as Topic; Fingolimod Hydrochloride; Humans; Immunologic Factors; Indans; Indoles; Multiple Sclerosis; Naphthalenes; Oxadiazoles; Propanolamines; Receptors, Lysosphingolipid; Thiazoles; Treatment Outcome | 2017 |
Helicase-primase inhibitor amenamevir for herpesvirus infection: Towards practical application for treating herpes zoster.
Topics: Animals; Antiviral Agents; DNA Helicases; DNA Primase; Drug Resistance, Viral; Herpes Zoster; Herpesvirus 3, Human; Humans; Oxadiazoles; Pyridines; Sulfonamides; Thiazoles; Viral Proteins | 2017 |
Multiple sclerosis.
Topics: Azetidines; Benzyl Compounds; Demyelinating Diseases; Humans; Indans; Magnetic Resonance Imaging; Multiple Sclerosis; Oxadiazoles; Risk Factors; Thiazoles; Tomography, X-Ray Computed | 2018 |
Sphingosine 1-phosphate receptor modulators in multiple sclerosis and other conditions.
Topics: Animals; Azetidines; Benzyl Compounds; Clinical Trials as Topic; Fingolimod Hydrochloride; Humans; Immune System Diseases; Indans; Multiple Sclerosis; Nervous System Diseases; Oxadiazoles; Signal Transduction; Sphingosine 1 Phosphate Receptor Modulators; Sphingosine-1-Phosphate Receptors; Thiazoles | 2021 |
1 trial(s) available for thiazoles and oxadiazoles
| Article | Year |
|---|---|
Four compounds active against rhinovirus: comparison in vitro and in volunteers.
Topics: Adolescent; Adult; Antiviral Agents; Cell Line; Clinical Trials as Topic; Female; HeLa Cells; Humans; In Vitro Techniques; Male; Middle Aged; Oxadiazoles; Respiratory Tract Infections; Rhinovirus; Thiazoles; Urea; Virus Diseases | 1976 |
74 other study(ies) available for thiazoles and oxadiazoles
| Article | Year |
|---|---|
New acylthiosemicarbazides, thiazolidinones, and 1,3,4-oxadiazoles as possible anticonvulsants.
Topics: Animals; Anticonvulsants; Mice; Oxadiazoles; Semicarbazides; Thiazoles | 1992 |
Benzo[b]thiophenes, Part I: Synthesis and antimicrobial activity of benzo[b]thienyl-1,3,4-oxadiazole, -1,2,4-triazoline, and -thiazoline derivatives.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bacteria; Candida albicans; Microbial Sensitivity Tests; Oxadiazoles; Thiazoles; Thiophenes; Triazoles | 1992 |
Positive heterotropic allosteric regulators of dihydropyridine binding increase the Ca2+ affinity of the L-type Ca2+ channel. Stereoselective reversal by the novel Ca2+ antagonist BM 20.1140.
Topics: Alkaloids; Allosteric Regulation; Animals; Benzothiazoles; Benzylisoquinolines; Binding Sites; Binding, Competitive; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Cerebral Cortex; Diltiazem; Guinea Pigs; Isomerism; Isradipine; Kinetics; Macromolecular Substances; Models, Theoretical; Muscles; Oxadiazoles; Pyridines; Pyrrolidines; Rabbits; Thiazoles; Verapamil | 1991 |
Comparison of azabicyclic esters and oxadiazoles as ligands for the muscarinic receptor.
Topics: Aminoquinolines; Animals; Aza Compounds; Bridged Bicyclo Compounds; Cerebral Cortex; Ligands; Male; Mice; Oxadiazoles; Rats; Receptors, Muscarinic; Thiazoles | 1991 |
Synthesis and anthelminthic evaluation of 2-amidino-1,3,4-oxa and 1,3,4-thiadiazoles, structurally related to tetramisole.
Topics: Amidines; Animals; Anthelmintics; Chemical Phenomena; Chemistry; Filariasis; Filarioidea; Nematoda; Nematode Infections; Nippostrongylus; Oxadiazoles; Rats; Thiadiazoles; Thiazoles | 1990 |
Molecular approach to the calcium channel.
Topics: Animals; Benzothiazoles; Binding Sites; Brain; Calcium; Cattle; Chemical Phenomena; Chemistry; Diltiazem; Guinea Pigs; In Vitro Techniques; Ion Channels; Isradipine; Muscles; Myocardium; Nicotinic Acids; Nifedipine; Nimodipine; Nitrendipine; Oxadiazoles; Thiazoles; Verapamil | 1985 |
The effect of K+ and glutamate receptor agonists on the membrane potential of suspensions of primary cultures of rat astrocytes as measured with a cyanine dye, DiS-C2-(5).
Topics: Animals; Astrocytes; Benzothiazoles; Brain; Carbocyanines; Cells, Cultured; Glutamates; Glutamic Acid; Kainic Acid; Membrane Potentials; Oxadiazoles; Potassium; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Thiazoles; Veratridine | 1988 |
[UV-spectrophotometry in drug control. 39. Spectrophotometric behavior of substances with chromophores and auxochromes in aliphatic chains, in saturated heterocyclics and the heterocyclic compounds: furan, imidazole, thiazole, thiadiazole and oxadiazole].
Topics: Chemical Phenomena; Chemistry; Furans; Heterocyclic Compounds; Imidazoles; Oxadiazoles; Pharmaceutical Preparations; Spectrophotometry, Ultraviolet; Thiadiazoles; Thiazoles | 1988 |
Benzo-2,1,5-oxadiazoles--a novel class of heterocyclic monoamine oxidase inhibitors.
Topics: Animals; Carbon Radioisotopes; In Vitro Techniques; Kinetics; Male; Mitochondria, Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxadiazoles; Oxazoles; Rats; Structure-Activity Relationship; Thiadiazoles; Thiazoles; Tryptamines | 1974 |
4-nitrobenzofurazans and 4-nitrobenzofuroxans: a new class of thiol-neutralising agents and potent inhibitors of nucleic acid synthesis in leucocytes.
Topics: Animals; Benzene Derivatives; Cyclic N-Oxides; Ethylmaleimide; Glutathione; In Vitro Techniques; Indicators and Reagents; Leukocytes; Lymphocytes; Naphthoquinones; ortho-Aminobenzoates; Oxadiazoles; Oximes; RNA; Sheep; Sulfhydryl Compounds; Thiazoles; Tritium; Uridine | 1968 |
[Studies on nitrofuran and related compounds for medicinal purpose. XIV. Syntheses of thiadiazole and oxadiazole derivatives with nitrofuran nucleus and their structure-activity relationship].
Topics: Chemistry, Pharmaceutical; Nitrofurans; Oxadiazoles; Thiazoles | 1965 |
Synthesis and pharmacological properties of benzothiazole, 1,3-4-oxadiazole and 1,3,4-thiadiazole derivatives.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Benzothiazoles; Carrageenan; Edema; Lethal Dose 50; Male; Mice; Oxadiazoles; Pain Measurement; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Thiadiazoles; Thiazoles | 1994 |
Preparation of C-(2-deoxyhex/pent-1-enopyranosyl)heterocycles.
Topics: Cyanides; Glycosides; Indicators and Reagents; Magnetic Resonance Spectroscopy; Molecular Structure; Nucleosides; Optical Rotation; Oxadiazoles; Solvents; Stereoisomerism; Thiazoles; Triazoles | 1994 |
Synthesis and antibacterial activity of 5-aryl-2-[(alpha-chloro-alpha-phenylacetyl/alpha-bromopropionyl)amino]- 1,3,4-oxadiazoles and 2-[(5-aryl-1,3,4-oxadiazol-2-yl)imino]-5-phenyl/methyl-4-thiazolidinone s.
Topics: Animals; Anti-Bacterial Agents; Bacteria; Male; Mice; Microbial Sensitivity Tests; Oxadiazoles; Rats; Thiazoles | 1997 |
The novel hypoglycemic agent YM440 normalizes hyperglycemia without changing body fat weight in diabetic db/db mice.
Topics: 3T3 Cells; Adipose Tissue; Animals; Blood Glucose; Cell Differentiation; Chromans; Diabetes Mellitus, Type 2; Hyperglycemia; Hypoglycemic Agents; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mice, Transgenic; Oxadiazoles; Pioglitazone; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone; Weight Gain | 2000 |
Evidence for the participation of the nitric oxide-cyclic GMP pathway in the antinociceptive action of meloxicam in the formalin test.
Topics: Analgesics, Non-Narcotic; Animals; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Formaldehyde; Guanylate Cyclase; Meloxicam; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Pain; Pain Measurement; Quinoxalines; Rats; Rats, Wistar; Thiazines; Thiazoles | 2000 |
Antihyperglycemic activity of new 1,2,4-oxadiazolidine-3,5-diones.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Disease Models, Animal; Female; Hypoglycemic Agents; Insulin; Male; Mice; Mice, Obese; Oxadiazoles; Structure-Activity Relationship; Thiazoles; Thiazolidinediones | 2001 |
New oxadiazolidinedione derivatives as potent and selective human beta3 agonists.
Topics: Adrenergic beta-3 Receptor Agonists; Adrenergic beta-Agonists; Animals; CHO Cells; Cricetinae; Cyclic AMP; Humans; Oxadiazoles; Protein Binding; Sensitivity and Specificity; Structure-Activity Relationship; Thiazoles; Thiazolidinediones | 2001 |
Differential effects of YM440 a hypoglycemic agent on binding to a peroxisome proliferator-activated receptor gamma and its transactivation.
Topics: 3T3 Cells; Adipose Tissue; Animals; Binding Sites; Biological Transport; Carrier Proteins; Diabetes Mellitus; Disease Models, Animal; Fatty Acid-Binding Proteins; Fish Proteins; Glucokinase; Humans; Hypoglycemic Agents; Ion Channels; Liver; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mitochondrial Proteins; Oxadiazoles; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Trypsin; Tumor Cells, Cultured; Uncoupling Protein 1 | 2003 |
HYPOGLYCEMIC ACTIVITY IN RELATION TO CHEMICAL STRUCTURE OF POTENTIAL ORAL ANTIDIABETIC SUBSTANCES. III. 2-BENZENESULFONAMIDO-5-ALKYL-1,3,4- THIADIAZOLES AND -OXADIAZOLES.
Topics: Animals; Chemical Phenomena; Chemistry; Hypoglycemic Agents; Lagomorpha; Oxadiazoles; Pharmacology; Rabbits; Rats; Research; Thiadiazoles; Thiazoles | 1962 |
POTENTIAL HYPOGLYCEMIC AGENTS: 1,3,4-OXADIAZOLES AND RELATED COMPOUNDS.
Topics: Chemical Phenomena; Chemistry; Dogs; Hypoglycemic Agents; Oxadiazoles; Pharmacology; Rats; Research; Thiazoles | 1962 |
EFFECT ON CATALASE IN VIVO AND IN VITRO OF COMPOUNDS RELATED TO AMINOTRIAZOLE. ANL-6823.
Topics: Amitrole; Azides; Azoles; Catalase; Enzyme Inhibitors; Erythrocytes; Imidazoles; In Vitro Techniques; Isoniazid; Kidney; Liver; Oxadiazoles; Oxazoles; Oxidation-Reduction; Pentylenetetrazole; Pharmacology; Pyrazoles; Rats; Research; Thiazoles; Triazoles | 1964 |
Rho kinase-induced nuclear translocation of ERK1/ERK2 in smooth muscle cell mitogenesis caused by serotonin.
Topics: Active Transport, Cell Nucleus; Amides; Animals; Benzamides; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Cell Division; Cells, Cultured; Cytochalasin D; Enzyme Activation; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Myosin-Light-Chain Phosphatase; Oxadiazoles; Phosphoproteins; Phosphorylation; Piperazines; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Subunits; Protein Transport; Pulmonary Artery; Pyridines; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Recombinant Fusion Proteins; rho-Associated Kinases; Serotonin; Serotonin 5-HT1 Receptor Antagonists; Signal Transduction; Thiazoles; Thiazolidines; Transcription Factors | 2004 |
Kinetic and crystallographic studies on 2-(beta-D-glucopyranosyl)-5-methyl-1, 3, 4-oxadiazole, -benzothiazole, and -benzimidazole, inhibitors of muscle glycogen phosphorylase b. Evidence for a new binding site.
Topics: Benzimidazoles; Binding Sites; Crystallography, X-Ray; Enzyme Inhibitors; Glucosides; Kinetics; Models, Molecular; Oxadiazoles; Phosphorylase b; Thiazoles | 2005 |
Additivity of molecular fields: CoMFA study on dual activators of PPARalpha and PPARgamma.
Topics: Benzofurans; Binding Sites; Drug Design; Ligands; Models, Molecular; Oxadiazoles; Oxazines; PPAR alpha; PPAR gamma; Protein Binding; Quantitative Structure-Activity Relationship; Thiazoles | 2005 |
Cytotoxicity, antitumoral and antimycobacterial activity of tetrazole and oxadiazole derivatives.
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Drug Design; Drug Screening Assays, Antitumor; Humans; Mycobacterium; Oxadiazoles; Structure-Activity Relationship; Tetrazoles; Tetrazolium Salts; Thiazoles | 2005 |
Regulation of p53 and suppression of apoptosis by the soluble guanylyl cyclase/cGMP pathway in human ovarian cancer cells.
Topics: Adenoviridae; Apoptosis; Atrial Natriuretic Factor; bcl-2-Associated X Protein; Benzothiazoles; Caspase 3; Caspases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclin-Dependent Kinase Inhibitor p21; Enzyme Activation; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Guanylate Cyclase; Half-Life; Humans; Mutation; Ovarian Neoplasms; Oxadiazoles; Phosphorylation; Proto-Oncogene Proteins c-mdm2; Quinoxalines; RNA, Small Interfering; Serine; Signal Transduction; Thiazoles; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53; X-Linked Inhibitor of Apoptosis Protein | 2006 |
Histamine decreases myogenic tone in rat cerebral arteries by H2-receptor-mediated KV channel activation, independent of endothelium and cyclic AMP.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Animals; Benzenesulfonates; Calcium; Cerebral Arteries; Cyclic AMP; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Histamine; Histamine Agonists; Histamine Antagonists; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Oxadiazoles; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Potassium Chloride; Quinoxalines; Rats; Rats, Sprague-Dawley; Thiazoles; Vasoconstriction; Vasodilation | 2006 |
Structure-activity relationships of 3,4-dihydro-1H-quinazolin-2-one derivatives as potential CDK5 inhibitors.
Topics: Benzimidazoles; Benzyl Compounds; Benzylamines; Binding Sites; Crystallography, X-Ray; Cyclin-Dependent Kinase 5; Hydrogen; Inhibitory Concentration 50; Isomerism; Models, Molecular; Molecular Structure; Oxadiazoles; Protein Kinase Inhibitors; Quinazolinones; Structure-Activity Relationship; Thiadiazoles; Thiazoles | 2007 |
Design of mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and new structural templates.
Topics: Amyloidosis; Benzamides; Benzothiazoles; Cell Line; Cell Survival; Cross-Linking Reagents; Drug Design; Fluorescence; Glutaral; Humans; Kinetics; Models, Molecular; Oxadiazoles; Phenyl Ethers; Prealbumin; Protein Denaturation; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Structure-Activity Relationship; Thiazoles; Triazoles; Tryptophan | 2007 |
Inhibition of GSK-3 reduces infarct volume and improves neurobehavioral functions.
Topics: Animals; Behavior, Animal; Blood Glucose; Brain Edema; Calcium-Binding Proteins; Caspase 3; Cerebral Infarction; Cyclooxygenase 2; Disease Models, Animal; Glial Fibrillary Acidic Protein; Glycogen Synthase Kinase 3; Microfilament Proteins; Oxadiazoles; Poly(ADP-ribose) Polymerases; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; Thiazoles; Urea | 2008 |
Structural rationale for the coupled binding and unfolding of the c-Myc oncoprotein by small molecules.
Topics: Amino Acid Sequence; Binding Sites; Humans; Molecular Sequence Data; Mutation; Oxadiazoles; Protein Binding; Protein Conformation; Protein Denaturation; Protein Multimerization; Proto-Oncogene Proteins c-myc; Thiazoles | 2008 |
Endothelium-derived nitric oxide contributes to the vasorelaxant response induced by mesoionic 2-(4-chlorophenyl)-3-methyl-4-(4-methoxyphenyl)-1;3-thiazolium-5-thyolate (CMMTT) in rats.
Topics: Animals; Biological Factors; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Male; Mesenteric Artery, Superior; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Oxadiazoles; Phenylephrine; Quinoxalines; Rats; Rats, Wistar; Thiazoles; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2009 |
SAR and optimization of thiazole analogs as potent stearoyl-CoA desaturase inhibitors.
Topics: Administration, Oral; Animals; Dietary Fats; Enzyme Inhibitors; Hep G2 Cells; Humans; Hypoglycemic Agents; Mice; Mice, Inbred C57BL; Oxadiazoles; Stearoyl-CoA Desaturase; Structure-Activity Relationship; Thiazoles; Weight Gain | 2010 |
Synthesis of some novel 2-substituted-5-[isopropylthiazole] clubbed 1,2,4-triazole and 1,3,4-oxadiazoles as potential antimicrobial and antitubercular agents.
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Antitubercular Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Oxadiazoles; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Triazoles | 2010 |
Properties of Rikkunshi-to (TJ-43)-induced relaxation of rat gastric fundus smooth muscles.
Topics: Animals; Apamin; Drugs, Chinese Herbal; Enprostil; Gastric Fundus; Hesperidin; Membrane Potentials; Muscle Relaxation; Muscle, Smooth; Oxadiazoles; Potassium; Pyrimidinones; Quinoxalines; Rats; Thiazoles; Verapamil | 2010 |
Thiazole, oxadiazole, and carboxamide derivatives of artemisinin are highly selective and potent inhibitors of Toxoplasma gondii.
Topics: Amides; Animals; Antiparasitic Agents; Antiprotozoal Agents; Artemisinins; Cell Line; Humans; Oxadiazoles; Parasitic Sensitivity Tests; Substrate Specificity; Thiazoles; Toxoplasma | 2010 |
In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of 10074-G5, a novel small-molecule inhibitor of c-Myc/Max dimerization.
Topics: Animal Structures; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Blood Proteins; Cell Line, Tumor; Cell Survival; Doxorubicin; Feces; Female; Glucuronates; Glucuronidase; HL-60 Cells; Humans; Inhibitory Concentration 50; Liver; Mice; Mice, SCID; Neoplasms; Oxadiazoles; Plasma; Protein Binding; Protein Multimerization; Proto-Oncogene Proteins c-myc; Tandem Mass Spectrometry; Thiazoles; Treatment Outcome; Urine; Xenograft Model Antitumor Assays | 2010 |
Synthesis and biological activity evaluation of 1,2,3-thiadiazole derivatives as potential elicitors with highly systemic acquired resistance.
Topics: Drug Resistance; Fungicides, Industrial; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Oxadiazoles; Spectrophotometry, Infrared; Thiadiazoles; Thiazoles | 2009 |
Stop codon read-through with PTC124 induces palmitoyl-protein thioesterase-1 activity, reduces thioester load and suppresses apoptosis in cultured cells from INCL patients.
Topics: Apoptosis; Cells, Cultured; Chromatography, Thin Layer; Codon, Nonsense; Codon, Terminator; Dose-Response Relationship, Drug; Enzyme Induction; Fluorescent Antibody Technique; Humans; Membrane Proteins; Microscopy, Electron, Transmission; Neuronal Ceroid-Lipofuscinoses; Oxadiazoles; Tetrazolium Salts; Thiazoles; Thiolester Hydrolases; Time Factors | 2011 |
Syntheses and evaluation of anti-inflammatory, analgesic and ulcerogenic activities of 1,3,4-oxadiazole and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole derivatives.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Female; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mice; Oxadiazoles; Spectroscopy, Fourier Transform Infrared; Stomach Ulcer; Thiazoles | 2012 |
Synthesis and antitumor evaluation of some new 1,3,4-oxadiazole-based heterocycles.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Chlorocebus aethiops; Hep G2 Cells; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Oxadiazoles; Spectroscopy, Fourier Transform Infrared; Structure-Activity Relationship; Thiazoles; Vero Cells | 2012 |
New drugs 2012 part I.
Topics: Aminopyridines; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Benzamides; Benzazepines; Benzimidazoles; Benzofurans; Ceftaroline; Cephalosporins; Cyclopropanes; Drug Approval; Drug Combinations; Humans; Imidazoles; Indoles; Isoindoles; Linagliptin; Lurasidone Hydrochloride; Macrolides; Oxadiazoles; Piperazines; Proline; Purines; Quinazolines; Thiazoles; United States; Vilazodone Hydrochloride | 2012 |
Synthesis, hypoglycemic and hypolipidemic activities of novel thiazolidinedione derivatives containing thiazole/triazole/oxadiazole ring.
Topics: Animals; Chemistry Techniques, Synthetic; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Hypolipidemic Agents; Male; Oxadiazoles; Rats; Rats, Wistar; Thiazoles; Thiazolidinediones; Triazoles | 2012 |
The cyclooxygenase and nitric oxide synthesis/pathways mediate the inhibitory serotonergic response to the pressor effect elicited by sympathetic stimulation in long-term diabetic pithed rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alloxan; Animals; Blood Pressure; Diabetes Mellitus, Experimental; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Piperazines; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Serotonin; Signal Transduction; Sympathetic Nervous System; Thiazoles | 2012 |
Imidazopyridine-based inhibitors of glycogen synthase kinase 3: synthesis and evaluation of amide isostere replacements of the carboxamide scaffold.
Topics: Drug Design; Glycogen Synthase Kinase 3; Humans; Molecular Dynamics Simulation; Oxadiazoles; Pyridines; Sulfonamides; Thiazoles | 2012 |
Sphingosine 1-phosphate (S1P) receptor agonists mediate pro-fibrotic responses in normal human lung fibroblasts via S1P2 and S1P3 receptors and Smad-independent signaling.
Topics: Actins; Animals; CHO Cells; Cricetinae; Cricetulus; Down-Regulation; Extracellular Matrix; Humans; Lung; Lysophospholipids; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myofibroblasts; Organophosphates; Oxadiazoles; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pulmonary Fibrosis; Receptors, Lysosphingolipid; Signal Transduction; Smad2 Protein; Smad3 Protein; Sphingosine; Thiazoles; Thiophenes; Transforming Growth Factor beta1 | 2013 |
In vitro and in vivo studies of the antiparasitic activity of sterol 14α-demethylase (CYP51) inhibitor VNI against drug-resistant strains of Trypanosoma cruzi.
Topics: 14-alpha Demethylase Inhibitors; Animals; Chagas Disease; Drug Resistance; Endoplasmic Reticulum; Golgi Apparatus; Imidazoles; Male; Mice; Microscopy, Electron, Transmission; Nitroimidazoles; Oxadiazoles; Protozoan Proteins; Sterol 14-Demethylase; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
Synthesis, antimicrobial and cytotoxic activities of some novel thiazole clubbed 1,3,4-oxadiazoles.
Topics: Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Escherichia coli; Fungi; HeLa Cells; Humans; Microbial Sensitivity Tests; Molecular Structure; Oxadiazoles; Pseudomonas aeruginosa; Staphylococcus aureus; Streptococcus pyogenes; Structure-Activity Relationship; Thiazoles | 2013 |
Discovery of N-{5-[3-(3-hydroxypiperidin-1-yl)-1,2,4-oxadiazol-5-yl]-4-methyl-1,3-thiazol-2-yl}acetamide (TASP0415914) as an orally potent phosphoinositide 3-kinase γ inhibitor for the treatment of inflammatory diseases.
Topics: Administration, Oral; Animals; Arthritis, Experimental; Class Ib Phosphatidylinositol 3-Kinase; Collagen; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; Enzyme Inhibitors; Male; Mice; Mice, Inbred DBA; Molecular Structure; Oxadiazoles; Phosphoinositide-3 Kinase Inhibitors; Structure-Activity Relationship; Thiazoles | 2013 |
GSK356278, a potent, selective, brain-penetrant phosphodiesterase 4 inhibitor that demonstrates anxiolytic and cognition-enhancing effects without inducing side effects in preclinical species.
Topics: Aminopyridines; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzamides; Callithrix; Cerebral Cortex; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Drug Evaluation, Preclinical; Ferrets; Inflammation; Isoenzymes; Macaca fascicularis; Male; Nootropic Agents; Oxadiazoles; Phosphodiesterase 4 Inhibitors; Pica; Rats; Rolipram; Thiazoles | 2014 |
AZD9272 and AZD2066: selective and highly central nervous system penetrant mGluR5 antagonists characterized by their discriminative effects.
Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Isoxazoles; Male; Oxadiazoles; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Thiazoles; Triazoles | 2014 |
The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1.
Topics: Anilides; Animals; Antineoplastic Agents, Phytogenic; Cytokines; Enzyme Activation; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Indans; Lysophospholipids; Male; Neuralgia; Organophosphonates; Oxadiazoles; Paclitaxel; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Thiazoles; Thiophenes | 2014 |
In vivo quantification and perturbation of Myc-Max interactions and the impact on oncogenic potential.
Topics: Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cell Line, Tumor; Cell Proliferation; HEK293 Cells; Humans; Luciferases, Renilla; Neoplasms; Oxadiazoles; Protein Binding; Protein Multimerization; Proto-Oncogene Proteins c-myc; Pyridines; Repressor Proteins; Thiazoles | 2014 |
Preclinical antitumor efficacy of selective exportin 1 inhibitors in glioblastoma.
Topics: Acrylamides; Active Transport, Cell Nucleus; Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Cycle Checkpoints; Cell Differentiation; Cell Line, Tumor; Dose-Response Relationship, Drug; Exportin 1 Protein; Glioblastoma; Humans; Hydrazines; Karyopherins; Macaca fascicularis; Male; Mice; Oxadiazoles; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Thiazoles; Treatment Outcome; Triazoles; Xenograft Model Antitumor Assays | 2015 |
ΔF508-CFTR correctors: synthesis and evaluation of thiazole-tethered imidazolones, oxazoles, oxadiazoles, and thiadiazoles.
Topics: Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Humans; Imidazoles; Kinetics; Molecular Conformation; Oxadiazoles; Oxazoles; Protein Binding; Structure-Activity Relationship; Thermodynamics; Thiadiazoles; Thiazoles; Water | 2014 |
Anti-tumor activity of selective inhibitors of XPO1/CRM1-mediated nuclear export in diffuse malignant peritoneal mesothelioma: the role of survivin.
Topics: Acrylamides; Active Transport, Cell Nucleus; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Exportin 1 Protein; G1 Phase Cell Cycle Checkpoints; Humans; Hydrazines; Inhibitor of Apoptosis Proteins; Karyopherins; Lung Neoplasms; Mesothelioma; Mesothelioma, Malignant; Mice; Mice, SCID; Neoplasm Proteins; Oxadiazoles; Peritoneal Neoplasms; Real-Time Polymerase Chain Reaction; Receptors, Cytoplasmic and Nuclear; Survivin; Thiazoles; Triazoles; Tumor Suppressor Protein p53 | 2015 |
Dissociable effects of mGluR5 allosteric modulation on distinct forms of impulsivity in rats: interaction with NMDA receptor antagonism.
Topics: Allosteric Regulation; Animals; Choice Behavior; Delay Discounting; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Imidazoles; Impulsive Behavior; Male; Motor Activity; Oxadiazoles; Piperidines; Pyridines; Rats; Reaction Time; Receptor, Metabotropic Glutamate 5; Receptors, N-Methyl-D-Aspartate; Thiazoles | 2015 |
GPR119: a promising target for nonalcoholic fatty liver disease.
Topics: AMP-Activated Protein Kinases; Animals; Cells, Cultured; Hep G2 Cells; Hepatocytes; Humans; Mesylates; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxadiazoles; Receptors, G-Protein-Coupled; Sterol Regulatory Element Binding Protein 1; Tetrazoles; Thiazoles | 2016 |
High conservation of herpes simplex virus UL5/UL52 helicase-primase complex in the era of new antiviral therapies.
Topics: Acyclovir; Antiviral Agents; DNA Helicases; DNA Primase; Drug Resistance, Viral; Herpesvirus 2, Human; Humans; Immunocompromised Host; Oxadiazoles; Polymorphism, Genetic; Pyridines; Simplexvirus; Sulfonamides; Thiazoles; Viral Proteins | 2016 |
Coumarin-thiazole and -oxadiazole derivatives: Synthesis, bioactivity and docking studies for aldose/aldehyde reductase inhibitors.
Topics: Aldehyde Reductase; Animals; Cattle; Coumarins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Molecular Docking Simulation; Molecular Structure; Oxadiazoles; Structure-Activity Relationship; Thiazoles | 2016 |
Anti-tumor activity of selective inhibitor of nuclear export (SINE) compounds, is enhanced in non-Hodgkin lymphoma through combination with mTOR inhibitor and dexamethasone.
Topics: Acrylamides; Active Transport, Cell Nucleus; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Survival; Cyclophosphamide; Dexamethasone; Dose-Response Relationship, Drug; Doxorubicin; Drug Synergism; Everolimus; Exportin 1 Protein; Humans; Hydrazines; Karyopherins; Lymphoma, Non-Hodgkin; Mice, Inbred ICR; Mice, SCID; Oxadiazoles; Prednisone; Protein Kinase Inhibitors; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Thiazoles; Time Factors; TOR Serine-Threonine Kinases; Transcription Factor RelA; Triazoles; Tumor Burden; Vincristine; Xenograft Model Antitumor Assays | 2016 |
APD668, a G protein-coupled receptor 119 agonist improves fat tolerance and attenuates fatty liver in high-trans fat diet induced steatohepatitis model in C57BL/6 mice.
Topics: Animals; Diet, High-Fat; Drug Interactions; Gastric Emptying; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Linagliptin; Male; Mesylates; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxadiazoles; Polyethylene Glycols; Pyrazoles; Pyrimidines; Receptors, G-Protein-Coupled; Tetrazoles; Thiazoles; Triglycerides | 2017 |
Biphenylthiazole antibiotics with an oxadiazole linker: An approach to improve physicochemical properties and oral bioavailability.
Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Biological Availability; Cell Line; Chemical Phenomena; Cricetinae; Humans; Male; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxadiazoles; Rats; Solubility; Structure-Activity Relationship; Thiazoles | 2018 |
Lipophilicity evaluation of some thiazolyl-1,3,4-oxadiazole derivatives with antifungal activity.
Topics: Antifungal Agents; Chromatography, Reverse-Phase; Chromatography, Thin Layer; Hydrophobic and Hydrophilic Interactions; Mass Spectrometry; Oxadiazoles; Principal Component Analysis; Thiazoles | 2018 |
Synthesis, docking and anticancer activity of azo-linked hybrids of 1,3,4-thia-/oxadiazoles with cyclic imides.
Topics: Antineoplastic Agents; Azo Compounds; Cell Proliferation; Chemistry Techniques, Synthetic; Humans; Imides; MCF-7 Cells; Molecular Docking Simulation; Oxadiazoles; Protein Conformation; Structure-Activity Relationship; Thiazoles | 2018 |
DS-8500a, an Orally Available G Protein-Coupled Receptor 119 Agonist, Upregulates Glucagon-Like Peptide-1 and Enhances Glucose-Dependent Insulin Secretion and Improves Glucose Homeostasis in Type 2 Diabetic Rats.
Topics: Animals; Benzamides; CHO Cells; Cricetulus; Cyclopropanes; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucagon-Like Peptide 1; Glucose; Homeostasis; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulin-Secreting Cells; Male; Mesylates; Mice; Oxadiazoles; Rats; Rats, Sprague-Dawley; Rats, Zucker; Receptors, G-Protein-Coupled; Tetrazoles; Thiazoles; Up-Regulation | 2018 |
GPR119 agonist enhances gefitinib responsiveness through lactate-mediated inhibition of autophagy.
Topics: Animals; Autophagy; Breast Neoplasms; Cell Line, Tumor; Drug Synergism; Female; Gefitinib; Humans; Lactic Acid; MCF-7 Cells; Mesylates; Mice, Inbred BALB C; Mice, Nude; Oxadiazoles; Receptors, G-Protein-Coupled; Tetrazoles; Thiazoles; Transfection | 2018 |
Oxadiazolylthiazoles as novel and selective antifungal agents.
Topics: Antifungal Agents; Aspergillus; Biofilms; Caco-2 Cells; Candida; Cryptococcus; Humans; Microbial Sensitivity Tests; Oxadiazoles; Stereoisomerism; Thiazoles | 2020 |
Synthesis and Antibacterial Evaluation of
Topics: Acetanilides; Animals; Anti-Bacterial Agents; Antinematodal Agents; Drug Design; Magnetic Resonance Spectroscopy; Oryza; Oxadiazoles; Plant Diseases; Structure-Activity Relationship; Thiazoles; Tylenchoidea; Xanthomonas; Xanthomonas axonopodis | 2020 |
Discovery and optimization of new oxadiazole substituted thiazole RORγt inverse agonists through a bioisosteric amide replacement approach.
Topics: Administration, Oral; Amides; Animals; Dose-Response Relationship, Drug; Drug Discovery; Microsomes, Liver; Molecular Structure; Nuclear Receptor Subfamily 1, Group F, Member 3; Oxadiazoles; Rats; Structure-Activity Relationship; Thiazoles | 2020 |
Synthesis, Characterization and Bioassay of Novel Substituted 1-(3-(1,3-Thiazol-2-yl)phenyl)-5-oxopyrrolidines.
Topics: Anti-Bacterial Agents; Bacillus cereus; Escherichia coli; Listeria monocytogenes; Microbial Sensitivity Tests; Molecular Structure; Oxadiazoles; Pyrrolidines; Staphylococcus aureus; Structure-Activity Relationship; Thiazoles | 2020 |
Harmine-inspired design and synthesis of benzo[d]imidazo[2,1-b]thiazole derivatives bearing 1,3,4-oxadiazole moiety as potential tumor suppressors.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Harmine; Humans; Imidazoles; Molecular Structure; Oxadiazoles; Structure-Activity Relationship; Thiazoles | 2021 |
Efficient Synthesis of Novel
Topics: Anti-Bacterial Agents; Benzamides; Molecular Docking Simulation; Oxadiazoles; Thiazoles | 2022 |