Compounds > thiazoles
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thiazoles and nsc 674495

thiazoles has been researched along with nsc 674495 in 9 studies

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (22.22)18.2507
2000's7 (77.78)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bradshaw, TD; Chua, MS; Hutchinson, I; Kashiyama, E; Kaur, G; Phillips, LR; Sausville, EA; Stevens, MF; Stinson, SF; Westwell, AD1
Bramhall, C; Buckley, J; Daw, TW; Phillips, LR; Stinson, SF1
Bradshaw, TD; Brantley, E; Chua, MS; Kashiyama, E; Sausville, EA; Stevens, MF; Stinson, SF1
Bradshaw, TD; Stevens, MF; Westwell, AD1
Bradshaw, TD; Hose, C; Loaiza-Pérez, AI; Sausville, EA; Singh, SS; Stevens, MF; Trapani, V; Trepel, JB1
Bradshaw, TD; Browne, HL; Chua, MS; Sausville, EA; Stevens, MF; Trapani, V1
Alley, MC; Bibby, MC; Bradshaw, TD; Cooper, PA; Donohue, S; Double, JA; Fichtner, I; Sausville, EA; Stevens, MF; Stinson, SF; Tomaszewjski, JE1
Ran, Y; Yalkowsky, SH1
Bradshaw, TD; Westwell, AD1

Reviews

2 review(s) available for thiazoles and nsc 674495

ArticleYear
The discovery of the potent and selective antitumour agent 2-(4-amino-3-methylphenyl)benzothiazole (DF 203) and related compounds.
    Current medicinal chemistry, 2001, Volume: 8, Issue:2

    Topics: Aniline Compounds; Animals; Antineoplastic Agents; Benzothiazoles; Humans; Prodrugs; Structure-Activity Relationship; Thiazoles

2001
The development of the antitumour benzothiazole prodrug, Phortress, as a clinical candidate.
    Current medicinal chemistry, 2004, Volume: 11, Issue:8

    Topics: Aniline Compounds; Animals; Antineoplastic Agents; Benzothiazoles; Cytochrome P-450 CYP1A1; Dose-Response Relationship, Drug; Drug Design; Prodrugs; Thiazoles; Time Factors

2004

Other Studies

7 other study(ies) available for thiazoles and nsc 674495

ArticleYear
Antitumor benzothiazoles. 8. Synthesis, metabolic formation, and biological properties of the C- and N-oxidation products of antitumor 2-(4-aminophenyl)benzothiazoles.
    Journal of medicinal chemistry, 1999, Oct-07, Volume: 42, Issue:20

    Topics: Aniline Compounds; Antineoplastic Agents; Benzothiazoles; Culture Media; Drug Screening Assays, Antitumor; Humans; Oxidation-Reduction; Radioligand Assay; Structure-Activity Relationship; Thiazoles; Tumor Cells, Cultured

1999
Analysis of 2-(3-methyl-4-aminophenyl)-benzothiazole (NSC 674495) in plasma by gas chromatography with mass-selective detection.
    Journal of chromatography. B, Biomedical sciences and applications, 1999, Sep-24, Volume: 732, Issue:2

    Topics: Aniline Compounds; Animals; Antineoplastic Agents; Benzothiazoles; Calibration; Gas Chromatography-Mass Spectrometry; Humans; Quality Control; Rats; Reproducibility of Results; Sensitivity and Specificity; Thiazoles

1999
Role of Cyp1A1 in modulation of antitumor properties of the novel agent 2-(4-amino-3-methylphenyl)benzothiazole (DF 203, NSC 674495) in human breast cancer cells.
    Cancer research, 2000, Sep-15, Volume: 60, Issue:18

    Topics: Aniline Compounds; Antineoplastic Agents; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Benzothiazoles; Breast Neoplasms; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Hydroxylation; Isoenzymes; Mixed Function Oxygenases; Protein Binding; Substrate Specificity; Thiazoles; Tumor Cells, Cultured

2000
Aryl hydrocarbon receptor mediates sensitivity of MCF-7 breast cancer cells to antitumor agent 2-(4-amino-3-methylphenyl) benzothiazole.
    Molecular pharmacology, 2002, Volume: 61, Issue:1

    Topics: Active Transport, Cell Nucleus; Aniline Compounds; Antineoplastic Agents; Aryl Hydrocarbon Hydroxylases; Benzothiazoles; Biological Transport; Breast Neoplasms; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Cytochrome P-450 Enzyme System; Drug Screening Assays, Antitumor; Enzyme Induction; Female; Humans; Promoter Regions, Genetic; Receptors, Aryl Hydrocarbon; Thiazoles; Transcription, Genetic; Tumor Cells, Cultured

2002
In vitro evaluation of amino acid prodrugs of novel antitumour 2-(4-amino-3-methylphenyl)benzothiazoles.
    British journal of cancer, 2002, Apr-22, Volume: 86, Issue:8

    Topics: Amines; Amino Acids; Aniline Compounds; Benzothiazoles; Blotting, Western; Cell Division; Cytochrome P-450 CYP1A1; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Neoplasms; Prodrugs; Thiazoles; Time Factors; Tumor Cells, Cultured

2002
Preclinical evaluation of amino acid prodrugs of novel antitumor 2-(4-amino-3-methylphenyl)benzothiazoles.
    Molecular cancer therapeutics, 2002, Volume: 1, Issue:4

    Topics: Amino Acids; Aniline Compounds; Animals; Antineoplastic Agents; Benzothiazoles; Blotting, Western; Cell Division; Cytochrome P-450 CYP1A1; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Humans; Male; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Ovarian Neoplasms; Prodrugs; Rats; Rats, Sprague-Dawley; Thiazoles; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2002
Halothane, a novel solvent for the preparation of liposomes containing 2-4'-amino-3'-methylphenyl benzothiazole (AMPB), an anticancer drug: a technical note.
    AAPS PharmSciTech, 2003, Volume: 4, Issue:2

    Topics: Aniline Compounds; Antineoplastic Agents; Benzothiazoles; Chemistry, Pharmaceutical; Drug Carriers; Halothane; Liposomes; Solvents; Thiazoles

2003