thiazoles has been researched along with nadp in 54 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (22.22) | 18.7374 |
| 1990's | 14 (25.93) | 18.2507 |
| 2000's | 21 (38.89) | 29.6817 |
| 2010's | 5 (9.26) | 24.3611 |
| 2020's | 2 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Kato, R; Sugiura, M | 1 |
| Bryan, GT; Chiu, CW; Kaiman, B; Wang, CY | 1 |
| Ezell, EL; Jackson, GR; Perez-Polo, JR; Post, JF; Werrbach-Perez, K | 1 |
| Boyd, MR; Monks, A; Pittman, A; Scudiero, D; Skehan, P; Vistica, DT | 1 |
| Davenport, JD; Hirsch, KS; Holden, HE; Jones, CD; Krumkalns, EV; Stamm, N; Suhr, RG; Taylor, HM; Winter, MA | 1 |
| Bublitz, C; Lawler, CA | 1 |
| Cannon, M; Leeder, JS; Nakhooda, A; Spielberg, SP | 1 |
| Krüger, S; Schlegel, W | 1 |
| Bryan, GT; Ichikawa, M; Swaminathan, S | 1 |
| Inglot, AD; Machoń, Z; Wolna, E | 1 |
| Behrens, BC; Bryan, GT; Ichikawa, M; Wang, CY | 1 |
| Feller, DR; Gillette, JR; Morita, M | 2 |
| Fustochenko, BP; Khokha, AM; Ostrovskiĭ, IuM | 1 |
| Galitskiĭ, EA; Senkevich, SB; Strumilo, SA; Vinogradov, VV | 1 |
| Iversen, LL; Ragan, CI; Shearman, MS | 1 |
| Petrash, JM; Quiocho, FA; Tarle, I; Wilson, DK | 1 |
| Berridge, MV; Tan, AS | 1 |
| Dunigan, DD; Owen, TC; Waters, SB | 1 |
| Andersson, A; Jordan, D; Lindqvist, Y; Schneider, G | 1 |
| Barth, P; Biellmann, JF; Potier, N; Tritsch, D; Van Dorsselaer, A | 1 |
| Andersson, A; Basarab, GS; Jordan, DB; Lindqvist, Y; Thompson, JE | 1 |
| Nakano, T; Petrash, JM; Quiocho, FA; Wilson, DK | 1 |
| Kimura, H; Liu, Y; Peterson, DA; Schubert, D | 1 |
| Carper, DA; El-Kabbani, O; Hohman, TC; Lai, K; Malamas, MS; McGowan, MH; Putilina, T; Wane, YQ | 1 |
| Horikoshi, H; Inoue, T; Yokoyama, T; Yoshida, Y | 1 |
| Flynn, TG; Hyndman, D; Jia, Z; Li, X; Ye, Q | 1 |
| Baillie, TA; Dean, D; Doss, G; Elmore, C; Kassahun, K; Leung, K; McIntosh, I; Pearson, PG; Tang, W; Wang, R | 1 |
| Hill, HM; Leach, RM; Robertson, TP; Snetkov, VA; Ward, JP | 1 |
| Bruno, G; Costantino, L; Curinga, C; Maccari, R; Monforte, F; Nicoló, F; Ottanà, R; Vigorita, MG | 1 |
| Meininger, CJ; Wu, G | 1 |
| Bozdag-Dundar, O; Buyukbingol, E; Can-Eke, B; Coban, T; Dundar, B; Iscan, M | 1 |
| Bernhard, D; Crazzolara, R; Csordas, A; Kofler, R; Schwaiger, W; Tinhofer, I | 1 |
| Ercolano, E; Lim, D; Moccia, F; Nusco, GA; Santella, L | 1 |
| Leonardi, R; Roach, PL | 1 |
| Damdimopoulos, AE; Nalvarte, I; Spyrou, G | 1 |
| Hazemann, I; Joachimiak, A; Karplus, M; Mitschler, A; Podjarny, A; Ruiz, F; Schneider, T | 1 |
| Castilho, RF; Kowaltowski, AJ; Maciel, EN; Rodrigues, JM; Schwalm, FD; Souza, DO; Vercesi, AE; Wajner, M | 1 |
| Awano, K; Dean, D; Hop, CE; Karanam, BV; Komuro, M; Liu, DQ; Satoh, H; Vincent, SH; Wallace, M | 1 |
| Doss, GA; Hop, CE; Karanam, BV; Liu, DQ; Sidler, RR; Vincent, SH | 1 |
| Ahmad, IM; Aykin-Burns, N; Buettner, GR; Flanagan, SW; Higashikubo, R; Mackey, MA; Oberley, LW; Sim, JE; Spitz, DR; Venkataraman, S; Walsh, SA | 1 |
| Aguirre, N; Ceña, V; Fernandez-Gomez, FJ; Galindo, MF; Gomez-Lazaro, M; González-García, C; Jordán, J | 1 |
| Reiser, G; Schönfeld, P | 1 |
| Adam-Vizi, V; Hegedus, V; Takacs, K; Tretter, L | 1 |
| Cai, Y; Finsi, J; Heimberg, H; Hinke, SA; Martens, GA; Pipeleers, D; Van de Casteele, M | 1 |
| Bult, H; Martinet, W; Schrijvers, DM; Timmermans, JP | 1 |
| Böttcher, C; Glawischnig, E; Prade, E; Scheel, D; Schmotz, C; Westphal, L | 1 |
| Liu, Y; Nair, MG | 1 |
| Iwatsubo, T; Miyashita, A; Takusagawa, S; Usui, T | 1 |
| Lamb, AL; Meneely, KM | 1 |
| Nakagawa, T; Nishimuta, H; Nomura, N; Yabuki, M | 1 |
| Engelhardt, H; Hübner, H; Präbst, K; Ringgeler, S | 1 |
| Gao, HY; Li, Y; Li, YT; Liu, MJ; Liu, P; Zhang, ZS; Zhao, SJ | 1 |
| Crouch, RD; Jackson, KD; Latham, BD; Oskin, DS; Vergne, MJ | 1 |
54 other study(ies) available for thiazoles and nadp
| Article | Year |
|---|---|
Reduction of tertiary amine N-oxides by rat liver mitochondria.
Topics: Adenosine Triphosphate; Amines; Aniline Compounds; Animals; Antimycin A; Benzothiazoles; Carbon Monoxide; Citric Acid Cycle; Cyanides; Dicarboxylic Acids; Digitonin; Imipramine; In Vitro Techniques; Male; Mitochondria, Liver; NAD; NADP; Oxidation-Reduction; Oxidoreductases Acting on CH-NH Group Donors; Oxygen; Phenobarbital; Piperazines; Rats; Rotenone; Thiazoles; Tricarboxylic Acids | 1977 |
Identification of 2-methyl-4-(5-amino-2-furyl) thiazole as the reduced metabolite of 2-methyl-4(5-nitro-2-furyl) thiazole.
Topics: Anaerobiosis; Animals; Chromatography, Gas; Cytochrome c Group; Cytochrome Reductases; Furans; Hydrogenation; In Vitro Techniques; Liver; Mass Spectrometry; NADP; Nitrofurans; Oxidation-Reduction; Rats; Thiazoles | 1975 |
Nerve growth factor effects on pyridine nucleotides after oxidant injury of rat pheochromocytoma cells.
Topics: Animals; Benzamides; Cell Death; Coloring Agents; Hydrogen Peroxide; Magnetic Resonance Spectroscopy; NAD; NADP; Nerve Growth Factors; Oxidation-Reduction; PC12 Cells; Poly Adenosine Diphosphate Ribose; Rats; Tetrazolium Salts; Thiazoles | 1992 |
Tetrazolium-based assays for cellular viability: a critical examination of selected parameters affecting formazan production.
Topics: Carcinoma, Renal Cell; Cell Division; Cell Line; Cell Survival; Coloring Agents; Drug Screening Assays, Antitumor; Formazans; Glucose; Humans; Kidney Neoplasms; Kinetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; NAD; NADP; Tetrazolium Salts; Thiazoles | 1991 |
Estrogen synthetase inhibitors. 2. Comparison of the in vitro aromatase inhibitory activity for a variety of nitrogen heterocycles substituted with diarylmethane or diarylmethanol groups.
Topics: Androstenedione; Animals; Aromatase; Aromatase Inhibitors; Benzhydryl Compounds; Chemical Phenomena; Chemistry; Female; Gonadotropins, Equine; Imidazoles; Microsomes; Molecular Structure; NADP; Ovary; Pyrazoles; Pyridines; Pyrimidines; Rats; Structure-Activity Relationship; Thiazoles; Triazoles; X-Ray Diffraction | 1990 |
The levels of nicotinamide nucleotides in liver microsomes and their possible significance to the function of hexose phosphate dehydrogenase.
Topics: Animals; Carbohydrate Dehydrogenases; Glucose-6-Phosphatase; Microsomes, Liver; NAD; NADP; Oxidation-Reduction; Phenazines; Rats; Tetrazolium Salts; Thiazoles | 1987 |
Drug metabolite toxicity assessed in human lymphocytes with a purified, reconstituted cytochrome P-450 system.
Topics: Acetaminophen; Animals; Cell Survival; Cytochrome P-450 Enzyme System; Glutathione; Glutathione Transferase; Humans; Lymphocytes; Male; NADP; Pyridines; Rats; Tetrazolium Salts; Thiazoles | 1988 |
Prostaglandin-E2 9-ketoreductase from human uterine decidua vera.
Topics: Acetates; Chromatography, High Pressure Liquid; Decidua; Dinoprost; Dinoprostone; Female; Humans; Indomethacin; Kinetics; Molecular Weight; NADP; Progesterone; Prostaglandins E; Prostaglandins F; Thiazoles | 1986 |
Identification of 4-(5-amino-2-furyl)thiazole (AFT) as a reductive metabolite of the carcinogen 4-(5-nitro-2-furyl)thiazole (NFT).
Topics: Animals; Chromatography, High Pressure Liquid; FANFT; Magnetic Resonance Spectroscopy; Mass Spectrometry; Microsomes, Liver; NADP; Rats; Thiazoles | 1986 |
New isothiazole derivatives. 3. Influence on glucose consumption and lactic acid production in tissue cultures.
Topics: Animals; Carboxylic Acids; Chick Embryo; Culture Media; Culture Techniques; Glucose; Lactates; NAD; NADP; Structure-Activity Relationship; Thiazoles | 1973 |
Nitroreduction of 5-nitrofuran derivatives by rat liver xanthine oxidase and reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase.
Topics: Acetamides; Allylisopropylacetamide; Animals; Carbon Radioisotopes; Chromatography, Ion Exchange; Cytochrome c Group; Cytochrome Reductases; Cytosol; Dialysis; Electron Transport; Female; Hydrazines; In Vitro Techniques; Liver; Methylcholanthrene; Microsomes, Liver; Milk; NADP; Nitrofurans; Nitrofurantoin; Oxidation-Reduction; Phenobarbital; Protein Binding; Rats; Thiazoles; Xanthine Oxidase | 1974 |
Enzymatic reduction of niridazole by rat liver microsomes.
Topics: Aerobiosis; Animals; Anthelmintics; Carbon Monoxide; Chemical Precipitation; Chromatography, Gas; Cytochromes; Guinea Pigs; Hydroxylamines; Imidazoles; Ketones; Lipase; Liver; Male; Mass Spectrometry; Methylcholanthrene; Mice; Microsomes, Liver; NAD; NADP; Nitro Compounds; Nitrogen; Oxidation-Reduction; Oxidoreductases; Oxygen; Pancreatic Juice; Phenobarbital; Quaternary Ammonium Compounds; Rabbits; Rats; Species Specificity; Spectrophotometry; Sulfates; Tetrazolium Salts; Thiazoles | 1971 |
Reduction of niridazole by rat liver santhine oxidase.
Topics: Adenine; Aerobiosis; Allopurinol; Anaerobiosis; Animals; Anthelmintics; Azaguanine; Chemical Precipitation; Chloramphenicol; Furazolidone; Hydrogen-Ion Concentration; Hypoxanthines; Imidazoles; Ketones; Kinetics; Liver; Male; Milk; NAD; NADP; Nitro Compounds; Nitrofurazone; Nitrophenols; Quaternary Ammonium Compounds; Rats; Sulfates; Thiazoles; Xanthine Oxidase | 1971 |
[Peculiarities of nucleotide and nucleic acid metabolism in hydroxythiamine-induced vitamin B1 deficiency].
Topics: Adenosine Triphosphate; Animals; DNA; Liver; Male; NAD; NADP; Nucleotides; Orotic Acid; Oxythiamine; Rats; RNA; Thiamine Deficiency; Thiazoles; Uridine Diphosphate Glucose | 1984 |
[Enzyme activity of thiamine pyrophosphate in the rat after oxythiamine administration].
Topics: 11-Hydroxycorticosteroids; Adrenal Glands; Animals; Cytosol; Male; Mitochondria; NADP; Oxidation-Reduction; Oxidoreductases; Oxythiamine; Rats; Substrate Specificity; Thiamine Pyrophosphate; Thiazoles | 1983 |
Inhibition of PC12 cell redox activity is a specific, early indicator of the mechanism of beta-amyloid-mediated cell death.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Animals; Cell Death; Dose-Response Relationship, Drug; Humans; Molecular Sequence Data; NAD; NADP; Neurons; Oxidation-Reduction; PC12 Cells; Rats; Species Specificity; Structure-Activity Relationship; Tetrazolium Salts; Thiazoles; Time Factors | 1994 |
Refined 1.8 A structure of human aldose reductase complexed with the potent inhibitor zopolrestat.
Topics: Aldehyde Reductase; Amino Acid Sequence; Benzothiazoles; Binding Sites; Humans; Models, Molecular; Molecular Structure; NADP; Phthalazines; Protein Conformation; Protein Structure, Secondary; Recombinant Proteins; Thiazoles; X-Ray Diffraction | 1993 |
Characterization of the cellular reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT): subcellular localization, substrate dependence, and involvement of mitochondrial electron transport in MTT reduction.
Topics: Animals; Antimycin A; Bone Marrow; Cell Line; Chloromercuribenzoates; Chlorpromazine; Coloring Agents; Cytochrome c Group; Electron Transport; Electron Transport Complex IV; Lysosomes; Mice; Mice, Inbred C3H; Mitochondria; NAD; NADP; Oxidation-Reduction; p-Chloromercuribenzoic Acid; Succinates; Succinic Acid; Tetrazolium Salts; Thenoyltrifluoroacetone; Thiazoles | 1993 |
Aqueous soluble tetrazolium/formazan MTS as an indicator of NADH- and NADPH-dependent dehydrogenase activity.
Topics: Dithiothreitol; Formazans; Indicators and Reagents; Kinetics; Mercaptoethanol; Methylphenazonium Methosulfate; NAD; NADH Dehydrogenase; NADP; NADPH Dehydrogenase; Oxidation-Reduction; Tetrazolium Salts; Thiazoles | 1995 |
Crystal structure of the ternary complex of 1,3,8-trihydroxynaphthalene reductase from Magnaporthe grisea with NADPH and an active-site inhibitor.
Topics: Amino Acid Sequence; Antifungal Agents; Ascomycota; Binding Sites; Computer Simulation; Crystallography, X-Ray; Enzyme Inhibitors; Fungal Proteins; Models, Molecular; Molecular Sequence Data; NADP; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Protein Conformation; Sequence Homology, Amino Acid; Thiazoles | 1996 |
Study of non-covalent enzyme-inhibitor complexes of aldose reductase by electrospray mass spectrometry.
Topics: Acetates; Aldehyde Reductase; Animals; Apoenzymes; Enzyme Inhibitors; Furans; Imidazoles; Imidazolidines; Lens, Crystalline; Mass Spectrometry; NADP; Naphthalenes; Rhodanine; Swine; Thiazoles; Thiazolidines | 1997 |
Trihydroxynaphthalene reductase from Magnaporthe grisea: realization of an active center inhibitor and elucidation of the kinetic mechanism.
Topics: Antifungal Agents; Ascomycota; Binding Sites; Binding, Competitive; Computer Simulation; Fungal Proteins; Hydrogen-Ion Concentration; Kinetics; NADP; Naphthols; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Spectrometry, Fluorescence; Substrate Specificity; Thiazoles | 1997 |
Structural studies of aldo-keto reductase inhibition.
Topics: Aldehyde Reductase; Benzothiazoles; Binding Sites; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Models, Structural; NADP; Phthalazines; Protein Structure, Secondary; Recombinant Proteins; Thiazoles | 1997 |
Mechanism of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction.
Topics: Animals; Brain; Cell Division; Cell Membrane Permeability; Coloring Agents; Endocytosis; Endosomes; Ethylmaleimide; Exocytosis; Lysosomes; Membrane Lipids; Mitochondria; NAD; NADP; Oxidation-Reduction; Oxidoreductases; Rats; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 1997 |
Probing the inhibitor-binding site of aldose reductase with site-directed mutagenesis.
Topics: Aldehyde Reductase; Benzothiazoles; Binding Sites; Computer Simulation; Enzyme Inhibitors; Humans; Imidazoles; Imidazolidines; Kinetics; Models, Molecular; Molecular Structure; Mutagenesis, Site-Directed; NADP; Naphthalenes; Phthalazines; Recombinant Proteins; Thiazoles | 1998 |
Inhibition of galactose-induced cataractogenesis by troglitazone, a new antidiabetic drug with an antioxidant property, in rat lens culture.
Topics: Aldehyde Reductase; Animals; Antioxidants; Cataract; Chromans; Galactitol; Galactose; Glutathione Peroxidase; Glutathione Reductase; Hypoglycemic Agents; Lens, Crystalline; Lipid Peroxides; NADP; Organ Culture Techniques; Organ Size; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Troglitazone; Vacuoles | 1999 |
Crystal structure of CHO reductase, a member of the aldo-keto reductase superfamily.
Topics: Alcohol Oxidoreductases; Amino Acid Sequence; Animals; Benzothiazoles; Catalytic Domain; CHO Cells; Cricetinae; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Models, Molecular; Molecular Sequence Data; NADP; Phthalazines; Protein Conformation; Sequence Homology, Amino Acid; Thiazoles | 2000 |
Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission.
Topics: Animals; Bile; Biotransformation; Catalysis; Chromans; Chromatography, Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Glutathione; Humans; Hypoglycemic Agents; Isoenzymes; Ketoconazole; Kinetics; Mass Spectrometry; Microsomes, Liver; NADP; Rats; Steroid Hydroxylases; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Divergent roles of glycolysis and the mitochondrial electron transport chain in hypoxic pulmonary vasoconstriction of the rat: identity of the hypoxic sensor.
Topics: Animals; Antimetabolites; Cyanides; Deoxyglucose; Electron Transport; Electron Transport Complex III; Enzyme Inhibitors; Glucose; Glycolysis; Hypoglycemic Agents; Hypoxia; Insulin; Iodoacetates; Male; Mesenteric Arteries; Methacrylates; Mitochondria; NADP; Pulmonary Artery; Pulmonary Circulation; Rats; Rats, Wistar; Rotenone; Succinic Acid; Thiazoles; Uncoupling Agents; Vasoconstriction | 2001 |
Synthesis and aldose reductase inhibitory activity of 5-arylidene-2,4-thiazolidinediones.
Topics: Aldehyde Reductase; Animals; Cattle; Enzyme Inhibitors; Hypoglycemic Agents; Imidazoles; Imidazolidines; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; NADP; Naphthalenes; Structure-Activity Relationship; Thiazoles; Thiazolidinediones | 2002 |
Regulation of endothelial cell proliferation by nitric oxide.
Topics: Animals; Biopterins; Blotting, Western; Cell Division; Coloring Agents; Coronary Vessels; Endothelium, Vascular; GTP Cyclohydrolase; Humans; Muscle, Skeletal; NADP; Nitric Oxide; Proliferating Cell Nuclear Antigen; Rats; Tetrazolium Salts; Thiazoles; Thymidine; Time Factors | 2002 |
Synthesis and antioxidative properties of novel thiazolidinedione/imidazolidinedione compounds as retinoids.
Topics: Animals; Antioxidants; Cytochrome c Group; In Vitro Techniques; Indicators and Reagents; Lipid Peroxidation; Male; Microsomes, Liver; NADP; Rats; Retinoids; Superoxides; Thiazoles | 2002 |
Enhanced MTT-reducing activity under growth inhibition by resveratrol in CEM-C7H2 lymphocytic leukemia cells.
Topics: Antioxidants; Apoptosis; Artifacts; Cell Division; Colorimetry; Dose-Response Relationship, Drug; Electron Transport; Formazans; Growth Inhibitors; Histocytochemistry; Humans; Indicators and Reagents; Leukemia, T-Cell; Mitochondria; NAD; NADP; Organ Specificity; Oxidation-Reduction; Resveratrol; Stilbenes; Subcellular Fractions; T-Lymphocytes; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 2003 |
NAADP activates a Ca2+ current that is dependent on F-actin cytoskeleton.
Topics: Actin Cytoskeleton; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium Channels; Calcium Signaling; Cell Membrane; Depsipeptides; Electric Conductivity; Models, Biological; NADP; Oocytes; Patch-Clamp Techniques; Peptides, Cyclic; Starfish; Thiazoles; Thiazolidines | 2003 |
Thiamine biosynthesis in Escherichia coli: in vitro reconstitution of the thiazole synthase activity.
Topics: Adenosine; Bacterial Proteins; Carbon-Sulfur Lyases; Carrier Proteins; Cell-Free System; Chromatography, High Pressure Liquid; Culture Media; Cysteine; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Escherichia coli Proteins; Ligases; Models, Chemical; NADP; Nucleotidyltransferases; Plasmids; S-Adenosylmethionine; Sulfurtransferases; Thiamine; Thiazoles; Time Factors; Tyrosine | 2004 |
Human mitochondrial thioredoxin reductase reduces cytochrome c and confers resistance to complex III inhibition.
Topics: Anti-Bacterial Agents; Antifungal Agents; Antimycin A; Cell Division; Cell Survival; Cells, Cultured; Cytochromes c; Electron Transport; Electron Transport Complex III; Humans; Kidney; Methacrylates; Mitochondria; NAD; NADP; Selenocysteine; Thiazoles; Thioredoxin Reductase 1; Thioredoxin Reductase 2; Thioredoxin-Disulfide Reductase; Thioredoxins | 2004 |
The crystallographic structure of the aldose reductase-IDD552 complex shows direct proton donation from tyrosine 48.
Topics: Aldehyde Reductase; Binding Sites; Carboxylic Acids; Crystallography, X-Ray; Enzyme Inhibitors; Fluorobenzenes; Humans; Hydrogen-Ion Concentration; Models, Molecular; Molecular Structure; NADP; Protein Structure, Tertiary; Protons; Thiazoles; Tyrosine | 2004 |
Mitochondrial permeability transition in neuronal damage promoted by Ca2+ and respiratory chain complex II inhibition.
Topics: Animals; Antimycin A; Bongkrekic Acid; Brain; Calcimycin; Calcium; Catalase; Cell Survival; Cyclosporins; Dose-Response Relationship, Drug; Drug Interactions; Electron Transport Complex II; Enzyme Inhibitors; Female; In Vitro Techniques; Ionophores; Malonates; Membrane Potentials; Methylmalonic Acid; Mitochondria; NADP; Neurons; Nitro Compounds; Oxygen Consumption; PC12 Cells; Permeability; Propionates; Rats; Rotenone; Tacrolimus; Tetrazolium Salts; Thiazoles; Uncoupling Agents | 2004 |
In vitro metabolism of MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl) phenyl]methyl]benzamide], a peroxisome proliferator-activated receptor alpha/gamma agonist. I. Role of cytochrome P450, methyltransferases, flavi
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzylamines; Carbon Radioisotopes; Cytosol; Dogs; Drug Evaluation, Preclinical; Esterases; Hepatocytes; Humans; Ketoconazole; Macaca mulatta; Methyltransferases; Microsomes, Liver; Mixed Function Oxygenases; NADP; PPAR alpha; PPAR gamma; Rats; S-Adenosylmethionine; Sulfhydryl Compounds; Sulfoxides; Temperature; Thiazoles; Thiazolidinediones | 2004 |
In vitro metabolism of MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl)-phenyl] methyl]benzamide], a peroxisome proliferator-activated receptor alpha/gamma agonist. II. Identification of metabolites by liquid chromato
Topics: Animals; Carbon Radioisotopes; Chromatography, Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dogs; Drug Evaluation, Preclinical; Glucuronides; Haplorhini; Hepatocytes; Humans; Mass Spectrometry; Microsomes, Liver; NADP; PPAR alpha; PPAR gamma; Rats; S-Adenosylmethionine; Sulfhydryl Compounds; Thiazoles; Thiazolidinediones | 2004 |
Mitochondrial O2*- and H2O2 mediate glucose deprivation-induced stress in human cancer cells.
Topics: Adenosine Triphosphate; Antimycin A; Antioxidants; Blotting, Western; Catalase; Cell Line, Transformed; Cell Line, Tumor; Cell Survival; Electron Spin Resonance Spectroscopy; Electron Transport; Electrons; Fibroblasts; Free Radicals; Glucose; Glutathione; Glutathione Reductase; Humans; Hydrogen Peroxide; Manganese; Methacrylates; Mitochondria; Models, Biological; NADP; Osteosarcoma; Oxidants; Oxidative Stress; Oxygen; Rotenone; Superoxide Dismutase; Thiazoles; Time Factors | 2005 |
Involvement of mitochondrial potential and calcium buffering capacity in minocycline cytoprotective actions.
Topics: Animals; Calcium; Cell Count; Cell Death; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Glutathione; Humans; Membrane Potentials; Minocycline; Mitochondria; Mitochondrial Swelling; NADP; Neuroblastoma; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Spectrophotometry; Staurosporine; Tetrazolium Salts; Thiazoles | 2005 |
Rotenone-like action of the branched-chain phytanic acid induces oxidative stress in mitochondria.
Topics: Aconitate Hydratase; Animals; Brain; Dose-Response Relationship, Drug; Electron Transport; Electron Transport Complex I; Electrons; Fatty Acids; Glutathione; Hydrogen Peroxide; Mitochondria; NADP; Oxidative Phosphorylation; Oxidative Stress; Oxygen; Palmitic Acid; Phytanic Acid; Rats; Rotenone; Tetrazolium Salts; Thiazoles; Time Factors; Uncoupling Agents | 2006 |
Characteristics of alpha-glycerophosphate-evoked H2O2 generation in brain mitochondria.
Topics: Animals; Antifungal Agents; Antimycin A; Brain; Cell Respiration; Electron Transport; Electron Transport Complex I; Electron Transport Complex III; Glycerolphosphate Dehydrogenase; Glycerophosphates; Guinea Pigs; Hydrogen Peroxide; Membrane Potential, Mitochondrial; Methacrylates; Mitochondria; NADP; Reactive Oxygen Species; Subcellular Fractions; Succinic Acid; Thiazoles; Uncoupling Agents | 2007 |
Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Biguanides; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Electron Transport; Electron Transport Complex I; Electron Transport Complex II; Enzyme Activation; Glucose; Hypoglycemic Agents; Insulin-Secreting Cells; Metformin; Mice; Mitochondria; Multienzyme Complexes; NADP; Oxidation-Reduction; Phenformin; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Succinates; Tetrazolium Salts; Thiazoles; Time Factors | 2007 |
Interactions between cell death induced by statins and 7-ketocholesterol in rabbit aorta smooth muscle cells.
Topics: Animals; Annexin A5; Autophagy; Caspases; Cell Death; Cell Survival; Cells, Cultured; Enzyme Activation; Flow Cytometry; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Ketocholesterols; Microscopy, Electron, Transmission; Mitochondria, Muscle; Myocytes, Smooth Muscle; NAD; NADP; Neutral Red; Plasmids; Rabbits; Tetrazolium Salts; Thiazoles | 2008 |
The multifunctional enzyme CYP71B15 (PHYTOALEXIN DEFICIENT3) converts cysteine-indole-3-acetonitrile to camalexin in the indole-3-acetonitrile metabolic network of Arabidopsis thaliana.
Topics: Arabidopsis; Arabidopsis Proteins; Cyanides; Cysteine; Cytochrome P-450 Enzyme System; Indoles; Mass Spectrometry; Metabolomics; NADP; Thiazoles | 2009 |
An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds.
Topics: Antioxidants; Coloring Agents; Formazans; Free Radical Scavengers; Mitochondria; Molecular Structure; NADP; Oxidation-Reduction; Plant Extracts; Singlet Oxygen; Tetrazolium Salts; Thiazoles | 2010 |
In vitro inhibition and induction of human cytochrome P450 enzymes by mirabegron, a potent and selective β3-adrenoceptor agonist.
Topics: Acetanilides; Adrenergic beta-3 Receptor Agonists; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Hepatocytes; High-Throughput Screening Assays; Humans; Male; Microsomes, Liver; Middle Aged; NADP; Recombinant Proteins; RNA, Messenger; Thiazoles; Time Factors | 2012 |
Two structures of a thiazolinyl imine reductase from Yersinia enterocolitica provide insight into catalysis and binding to the nonribosomal peptide synthetase module of HMWP1.
Topics: Bacterial Proteins; Catalysis; Crystallization; Crystallography, X-Ray; Models, Molecular; NADP; Oxidoreductases Acting on CH-NH Group Donors; Peptide Synthases; Phenols; Protein Structure, Tertiary; Pseudomonas aeruginosa; Thiazoles; Yersinia enterocolitica | 2012 |
Significance of reductive metabolism in human intestine and quantitative prediction of intestinal first-pass metabolism by cytosolic reductive enzymes.
Topics: Cytosol; Haloperidol; Humans; Intestinal Mucosa; Intestines; Liver; Mebendazole; NADP; Oxidation-Reduction; Piperazines; Thiazoles | 2013 |
Basic Colorimetric Proliferation Assays: MTT, WST, and Resazurin.
Topics: Biological Assay; Calibration; Cell Count; Cell Proliferation; Cell Survival; Colorimetry; HeLa Cells; Humans; Indicators and Reagents; NAD; NADP; Oxazines; Tetrazolium Salts; Thiazoles; Xanthenes | 2017 |
Photoprotection by mitochondrial alternative pathway is enhanced at heat but disabled at chilling.
Topics: Arabidopsis; Chlorophyll A; Cold Temperature; Glycine; Hot Temperature; Light; Methacrylates; Mitochondria; Mitochondrial Proteins; Mutation; NADP; Oxidoreductases; Photosynthesis; Plant Leaves; Plant Proteins; Serine; Thiazoles | 2020 |
Cytochromes P450 2C8 and 3A Catalyze the Metabolic Activation of the Tyrosine Kinase Inhibitor Masitinib.
Topics: Activation, Metabolic; Benzamides; Catalysis; COVID-19; Cytochrome P-450 Enzyme System; Humans; Microsomes, Liver; NADP; Piperidines; Potassium Cyanide; Protein Kinase Inhibitors; Pyridines; Thiazoles | 2022 |