Page last updated: 2024-08-21

thiazoles and n-(4-methoxybenzyl)-n'-(5-nitro-1,3-thiazol-2-yl)urea

thiazoles has been researched along with n-(4-methoxybenzyl)-n'-(5-nitro-1,3-thiazol-2-yl)urea in 69 studies

Research

Studies (69)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's20 (28.99)29.6817
2010's46 (66.67)24.3611
2020's3 (4.35)2.80

Authors

AuthorsStudies
Avila, J; Berg, S; Bhat, R; Borgegård, T; Díaz-Nido, J; Giménez-Cassina, A; Hellberg, S; Hernández, F; Jerning, E; Lucas, JJ; Markgren, PO; Nilsson, Y; Nylöf, M; Ormö, M; Radesäter, AC; Xue, Y1
Asuni, AA; Berg, S; Bhat, R; Drummond, JA; Jukes, JP; Lovestone, S; MacKay, D; Mears, A; Mildren, P; Mudher, A; Newman, TA; Shepherd, D; Squire, A1
Bhat, R; Einat, H; Gould, TD; Manji, HK1
Billadeau, DD; Fernandez-Zapico, ME; Ougolkov, AV; Savoy, DN; Urrutia, RA1
Garcia, A; Houle, S; Meyer, JH; Stableford, WT; Vasdev, N; Wilson, AA; Young, AB1
Caricasole, A; Gaviraghi, G; Terstappen, GC1
Bilim, VN; Billadeau, DD; Chari, ST; Fernandez-Zapico, ME; Ougolkov, AV; Smyrk, TC1
Hwang, S; Kim, HY; Kim, SH; Kim, Y; Koh, SH; Lee, CH1
Chen, R; Han, Y; Li, M; Li, W; Ruan, H; Wang, W; Wang, Y; Yang, Y; Ying, C; You, Y; Zhu, X1
Abad, MA; Camins, A; Enguita, M; Folch, J; Pallàs, M; Trullàs, R; Yeste-Velasco, M1
Chang, DI; Hwang, SJ; Kim, SH; Koh, SH; Yoo, AR1
Binfaré, RW; García, AG; Kaster, MP; López, MG; Martín-Aparicio, E; Martinez, A; Medina, M; Morales, S; Navarro-Rico, ML; Rodrigues, AL; Rosa, AO1
Baldwin, AS; Wilson, W1
Bauchwitz, RP; Chen, S; Jope, RS; Min, WW; Sikorski, C; Yan, Q; Yuskaitis, CJ1
Fujisawa, H; Hamada, J; Hayashi, Y; Kawakami, K; Mai, W; Minamoto, T; Miyashita, K; Nakada, M; Shakoori, A1
Cavalli, A; Gervasio, FL; Masetti, M; Recanatini, M1
Chen, YX; Filion, L; Hibbert, B; Holm, E; Ma, X; O'Brien, ER; Pourdjabbar, A; Rayner, K; Sun, J1
Achim, CL; Chana, G; Everall, IP; Grant, I; Hult, BJ; Lucero, GR; Masliah, E; Nguyen, TB; Tatro, ET1
Delgado-Martín, C; Escribano, C; Rodríguez-Fernández, JL1
Aponte, AM; Murphy, E; Steenbergen, C; Wong, R1
Bilim, V; Billadeau, D; Kawazoe, H; Motoyama, T; Muto, A; Naito, S; Ougolkov, A; Oya, M; Tomita, Y; Yuuki, K1
Dykstra, H; Fan, S; Mercer, AJ; Papugani, A; Persidsky, Y; Ramirez, SH; Reichenbach, N; Tuma, RF; Zhang, M1
Blood, JD; Pekary, AE; Sattin, A; Stevens, SA1
Blumenthal, R; Drevets, W; Du, J; Hunsberger, JG; Khairova, R; Liu, L; Machado-Vieira, R; Manji, HK; Tragon, T; Wang, Y; Wang, YT; Wei, Y1
Egea, J; Gadotti, VM; López, MG; Martins, DF; Mazzardo-Martins, L; Nascimento, FP; Rosa, AO; Santos, AR1
Chang, WT; Chen, CL; Huang, WC; Kai, JI; Lin, CF; Tsai, CC1
Dawson, LA; Kalinichev, M1
Bécsi, B; Csortos, C; Czikora, I; Erdodi, F; Gergely, P; Kása, A; Kim, KM; Verin, AD1
Krett, NL; Rosen, ST; Rovedo, MA1
Ban, JO; Han, SB; Hong, JT; Kang, KW; Moon, DC; Oh, JH; Son, SM; Song, HS; Song, MJ; Won, D1
Boländer, A; Dominguez, J; Eldar-Finkelman, H; Fuertes, A; Kramer, T; Monte, FL; Plotkin, B; Schmidt, B1
Ishigaki, Y; Kawakami, K; Kitano, A; Minamoto, T; Motoo, Y; Nakajima, H; Nakamura, Y; Nakaya, N; Sato, I; Shimasaki, T; Takata, T; Takegami, T; Tanaka, T; Tomosugi, N; Zhao, X1
Hicks, JW; Houle, S; Rubie, EA; Vasdev, N; Wilson, AA; Woodgett, JR1
Hu, Q; Lee, SY; O'Kusky, JR; Ye, P1
Fedoročko, P; Jendželovský, R; Koval, J; Mikeš, J; Papčová, Z; Plšíková, J1
Ahn, SW; Choi, WJ; Hong, YH; Kim, JE; Kim, SH; Kim, SM; Lee, KW; Park, KS; Sung, JJ1
Cidral-Filho, FJ; Martins, DF; Mazzardo-Martins, L; Santos, AR; Stramosk, J1
Dionyssiou, MG; Hashemi, S; Kerr, A; McDermott, JC; Nowacki, NB; Tsushima, RG; Zhao, J1
Anderson, NJ; Guernsey, LS; Jolivalt, CG; King, MR1
Roux, PP; Shin, S; Tcherkezian, J; Vallabhapurapu, S; Wolgamott, L; Yoon, SO; Yu, Y1
Chiappinelli, KB; Goodfellow, PJ; Kizer, NT; Ma, L; Thaker, PH; Trinkaus, KM; Yin, Y1
Gowda, R; Madhunapantula, SV; Robertson, GP; Sharma, A1
Gao, M; Maixner, DW; Weng, HR1
Azim, K; Butt, A; Cantù, C; Draganova, K; Fischer, B; Hurtado-Chong, A; Raineteau, O; Sommer, L; Zemke, M1
Carter, YM; Chen, H; Gamblin, TC; Kunnimalaiyaan, M; Kunnimalaiyaan, S1
Dent, P1
Chang, MS; Cho, SJ; Choi, Y; Choi, YS; Kim, MA; Ko, YS; Lee, BL; Lee, JS; Park, J; Pyo, JS; Ye, SK; Yoon, J; Youn, HD1
Ishioka, C; Suzuki, M; Takahashi, H; Yoshino, Y1
Gui, Y; Li, L; Shi, Z; Singh, P; Walsh, MP; Yin, H; Yu, YN; Zheng, XL; Zhou, YX1
Gamblin, TC; Kunnimalaiyaan, M; Kunnimalaiyaan, S1
Ishioka, C; Yoshino, Y1
Bali, A; Jaggi, AS2
Al-Onaizi, M; Barbash, S; Bekenstein, U; Fahnestock, M; Haberman, N; Hanin, G; Kish, MT; Kolisnyk, B; Prado, MAM; Prado, VF; Soreq, H; Soreq, L; Souza da Silva, J; Ule, J1
Carvalho, AF; Dal-Pont, GC; de Souza, CT; Farias, HR; Jornada, LK; Machado, AG; Peterle, BR; Quevedo, J; Resende, WR; Valvassori, SS1
Feng, Y; Hu, B; Rong, N; Yang, R; Zhang, J; Zhang, Q; Zhang, W1
Huang, CF; Liu, HS; Ramesh, C; Su, CL; Tseng, CL; Yao, CF1
Abdel-Hakeem, MS; Houghton, M; Mason, AL; Sarhan, MA; Tyrrell, DL1
Liu, Y; Zhang, M; Zhang, P; Zhou, Y1
Aristizabal Prada, ET; Auernhammer, CJ; Grabowski, P; Grossman, A; Lauseker, M; Maurer, J; Nölting, S; Orth, M; Spöttl, G; Weis, C1
Deng, H; Deng, Z; Liu, L; Liu, X; Liu, Y; Pang, W; Song, D; Zeng, Q; Zhang, N1
Ahmed, E; Ballabh, P; Cheng, B; Dohare, P; Kayton, R; Singla, P; Thomas, S; Ungvari, Z; Yadala, V1
Dal-Pont, GC; Menegas, S; Peterle, BR; Quevedo, J; Resende, WR; Trajano, KS; Valvassori, SS; Varela, RB1
Chung, YH; Hsu, PH; Lin, KJ; Lin, YT; Liu, HL; Yang, LY; Yen, TC1
Ballabh, P; Dohare, P; Hevner, R; Kaur, J; Kidwai, A; Klebe, D; Krishna, S; Singla, P; Zhang, X1
Chai, HH; Chen, GZ; Chen, WX; Chen, YS; Fu, XC; Guo, YW; Li, SP; Ma, L; Song, MY; Sun, HT; Tan, MX1
Abe, K; Aiba, H; Aoki, Y; Araki, Y; Bolidong, D; Domoto, T; Hayashi, K; Higuchi, T; Igarashi, K; Inatani, H; Minamoto, T; Miwa, S; Takeuchi, A; Taniguchi, Y; Tsuchiya, H; Yamamoto, N; Yonezawa, H1
Chang, LS; Chiou, JT; Huang, CH; Lee, YC; Shi, YJ; Wang, LJ1
Besen, MH; Dalsenter, YO; Kaufmann, FN; Moretti, M; Neis, VB; Platt, N; Rodrigues, ALS; Rosa, PB; Rosado, AF; Werle, I1

Other Studies

69 other study(ies) available for thiazoles and n-(4-methoxybenzyl)-n'-(5-nitro-1,3-thiazol-2-yl)urea

ArticleYear
Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418.
    The Journal of biological chemistry, 2003, Nov-14, Volume: 278, Issue:46

    Topics: Adenosine Triphosphate; Animals; CDC2-CDC28 Kinases; Cell Death; Cell Line, Tumor; Cell Survival; Crystallography, X-Ray; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Electrons; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Humans; Inhibitory Concentration 50; Kinetics; Mice; Models, Chemical; Models, Molecular; Neurons; NIH 3T3 Cells; Peptides; Protein Binding; Signal Transduction; tau Proteins; Thiazoles; Urea

2003
GSK-3beta inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila.
    Molecular psychiatry, 2004, Volume: 9, Issue:5

    Topics: Animals; Axonal Transport; Axons; Drosophila melanogaster; Drosophila Proteins; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Humans; Larva; Lithium Chloride; Locomotion; Phosphorylation; Protein Processing, Post-Translational; Recombinant Fusion Proteins; tau Proteins; Tauopathies; Thiazoles; Urea

2004
AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test.
    The international journal of neuropsychopharmacology, 2004, Volume: 7, Issue:4

    Topics: Amphetamine; Animals; Antidepressive Agents; Central Nervous System Stimulants; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Swimming; Thiazoles; Urea

2004
Glycogen synthase kinase-3beta participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells.
    Cancer research, 2005, Mar-15, Volume: 65, Issue:6

    Topics: Apoptosis; Cell Growth Processes; Cell Line, Tumor; Cell Survival; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; NF-kappa B; Pancreatic Neoplasms; Thiazoles; Transcription, Genetic; Urea

2005
Synthesis and ex vivo evaluation of carbon-11 labelled N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea ([11C]AR-A014418): a radiolabelled glycogen synthase kinase-3beta specific inhibitor for PET studies.
    Bioorganic & medicinal chemistry letters, 2005, Dec-01, Volume: 15, Issue:23

    Topics: Animals; Carbon Radioisotopes; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Isotope Labeling; Positron-Emission Tomography; Rats; Rats, Sprague-Dawley; Thiazoles; Tissue Distribution; Urea

2005
The Wnt signaling pathway as a target for the treatment of neurodegenerative disorders.
    IDrugs : the investigational drugs journal, 2006, Volume: 9, Issue:1

    Topics: Animals; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Homeostasis; Humans; Indoles; Lithium Chloride; Maleimides; Models, Biological; Nervous System; Neurodegenerative Diseases; Pyridines; Pyrimidines; Signal Transduction; Thiazoles; Urea; Wnt Proteins

2006
Aberrant nuclear accumulation of glycogen synthase kinase-3beta in human pancreatic cancer: association with kinase activity and tumor dedifferentiation.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Sep-01, Volume: 12, Issue:17

    Topics: Adenocarcinoma; Animals; Apoptosis; Cell Differentiation; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Female; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Male; Mice; Mice, Nude; Middle Aged; NF-kappa B; Pancreatic Neoplasms; Structure-Activity Relationship; Survival Rate; Thiazoles; Transplantation, Heterologous; Urea; Xenograft Model Antitumor Assays

2006
Inhibition of glycogen synthase kinase-3 suppresses the onset of symptoms and disease progression of G93A-SOD1 mouse model of ALS.
    Experimental neurology, 2007, Volume: 205, Issue:2

    Topics: Amyotrophic Lateral Sclerosis; Animals; Blotting, Western; Caspase 3; Cell Death; Cyclooxygenase 2; Cytochromes c; Cytosol; Disease Progression; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Humans; In Situ Nick-End Labeling; Intercellular Adhesion Molecule-1; Mice; Mice, Transgenic; Motor Neurons; Poly(ADP-ribose) Polymerases; Postural Balance; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1; Thiazoles; Urea

2007
Inhibition of glycogen synthase kinase-3beta protects dopaminergic neurons from MPTP toxicity.
    Neuropharmacology, 2007, Volume: 52, Issue:8

    Topics: Analysis of Variance; Animals; Apoptosis; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Freezing Reaction, Cataleptic; Glycogen Synthase Kinase 3; Indoles; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Neurons; Oximes; tau Proteins; Thiazoles; Tyrosine 3-Monooxygenase; Urea

2007
Glycogen synthase kinase-3 is involved in the regulation of the cell cycle in cerebellar granule cells.
    Neuropharmacology, 2007, Volume: 53, Issue:2

    Topics: Analysis of Variance; Animals; Animals, Newborn; Apoptosis; Cell Cycle; Cells, Cultured; Cerebellum; Cyclin E; Enzyme Activation; Enzyme Inhibitors; Flow Cytometry; Glycogen Synthase Kinase 3; Immunoprecipitation; Lithium; Neurons; Potassium Deficiency; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serum; Thiazoles; Time Factors; Urea

2007
Inhibition of GSK-3 reduces infarct volume and improves neurobehavioral functions.
    Biochemical and biophysical research communications, 2008, Jul-11, Volume: 371, Issue:4

    Topics: Animals; Behavior, Animal; Blood Glucose; Brain Edema; Calcium-Binding Proteins; Caspase 3; Cerebral Infarction; Cyclooxygenase 2; Disease Models, Animal; Glial Fibrillary Acidic Protein; Glycogen Synthase Kinase 3; Microfilament Proteins; Oxadiazoles; Poly(ADP-ribose) Polymerases; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; Thiazoles; Urea

2008
Antidepressant-like effect of the novel thiadiazolidinone NP031115 in mice.
    Progress in neuro-psychopharmacology & biological psychiatry, 2008, Aug-01, Volume: 32, Issue:6

    Topics: Animals; Antidepressive Agents; Cyclic AMP-Dependent Protein Kinases; Cyclin-Dependent Kinase 5; Enzyme Inhibitors; Female; Glycogen Synthase Kinase 3; Male; Mice; Mitogen-Activated Protein Kinases; Motor Activity; PPAR gamma; Rosiglitazone; Swimming; Thiazoles; Thiazolidinediones; Urea

2008
Maintenance of constitutive IkappaB kinase activity by glycogen synthase kinase-3alpha/beta in pancreatic cancer.
    Cancer research, 2008, Oct-01, Volume: 68, Issue:19

    Topics: Cell Proliferation; Cell Survival; Enzyme Activation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; I-kappa B Kinase; Isoenzymes; NF-kappa B; Pancreatic Neoplasms; Protein Binding; Thiazoles; Tumor Cells, Cultured; Urea

2008
Elevated glycogen synthase kinase-3 activity in Fragile X mice: key metabolic regulator with evidence for treatment potential.
    Neuropharmacology, 2009, Volume: 56, Issue:2

    Topics: Acoustic Stimulation; Analysis of Variance; Animals; Antimanic Agents; Brain; Citrates; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Exploratory Behavior; Fragile X Mental Retardation Protein; Gene Expression Regulation; Glycogen Synthase Kinase 3; Indoles; Lithium Chloride; Male; Maleimides; Mice; Mice, Knockout; Pyridines; Seizures; Serine; Thiazoles; Urea

2009
Potential therapeutic effect of glycogen synthase kinase 3beta inhibition against human glioblastoma.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, Feb-01, Volume: 15, Issue:3

    Topics: Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Evaluation, Preclinical; Glioblastoma; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Radiation-Sensitizing Agents; RNA Interference; Thiazoles; Urea

2009
Exploring complex protein-ligand recognition mechanisms with coarse metadynamics.
    The journal of physical chemistry. B, 2009, Apr-09, Volume: 113, Issue:14

    Topics: Binding Sites; Computer Simulation; Crystallography, X-Ray; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Escherichia coli; Estrogen Receptor alpha; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Ligands; Models, Chemical; Models, Molecular; Molecular Structure; Tamoxifen; Thermodynamics; Thiazoles; Triclosan; Urea

2009
Inhibition of endothelial progenitor cell glycogen synthase kinase-3beta results in attenuated neointima formation and enhanced re-endothelialization after arterial injury.
    Cardiovascular research, 2009, Jul-01, Volume: 83, Issue:1

    Topics: Animals; Apoptosis; Arteries; Cell Adhesion; Cell Survival; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Homeostasis; Humans; Integrin alpha4; Mesenchymal Stem Cells; Mice; Models, Animal; Neovascularization, Pathologic; Thiazoles; Tunica Intima; Urea; Vascular Endothelial Growth Factor A

2009
Glycogen synthase kinase-3beta (GSK-3beta) inhibitors AR-A014418 and B6B3O prevent human immunodeficiency virus-mediated neurotoxicity in primary human neurons.
    Journal of neurovirology, 2009, Volume: 15, Issue:5-6

    Topics: AIDS Dementia Complex; Caspase 3; Caspase 7; Cells, Cultured; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Indoles; L-Lactate Dehydrogenase; Macrophages; Necrosis; Nerve Degeneration; Neurons; Oximes; Thiazoles; Urea

2009
CCR7-dependent stimulation of survival in dendritic cells involves inhibition of GSK3beta.
    Journal of immunology (Baltimore, Md. : 1950), 2009, Nov-15, Volume: 183, Issue:10

    Topics: Adjuvants, Immunologic; Animals; Apoptosis; Cell Survival; Chemokine CCL19; Chemokine CCL21; Dendritic Cells; Extracellular Signal-Regulated MAP Kinases; Forkhead Box Protein O1; Forkhead Transcription Factors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; I-kappa B Kinase; Lithium Chloride; Mice; Mice, Inbred C57BL; NF-kappa B; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptors, CCR7; Signal Transduction; Thiazoles; Urea

2009
Cardioprotection leads to novel changes in the mitochondrial proteome.
    American journal of physiology. Heart and circulatory physiology, 2010, Volume: 298, Issue:1

    Topics: Animals; Blotting, Western; Cardiotonic Agents; Cytochromes c; Electron Transport; Electrophoresis, Polyacrylamide Gel; Energy Metabolism; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Hemodynamics; Ischemic Preconditioning, Myocardial; Mice; Mice, Inbred C57BL; Mitochondria, Heart; Myocardium; Necrosis; Proteome; Thiazoles; Urea

2010
Glycogen synthase kinase-3: a new therapeutic target in renal cell carcinoma.
    British journal of cancer, 2009, Dec-15, Volume: 101, Issue:12

    Topics: Adult; Aged; Carcinoma, Renal Cell; Cell Proliferation; Cell Survival; Docetaxel; Female; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Kidney Neoplasms; Male; Middle Aged; NF-kappa B; Proto-Oncogene Proteins c-bcl-2; Taxoids; Thiazoles; Urea; X-Linked Inhibitor of Apoptosis Protein

2009
Inhibition of glycogen synthase kinase 3beta (GSK3beta) decreases inflammatory responses in brain endothelial cells.
    The American journal of pathology, 2010, Volume: 176, Issue:2

    Topics: AIDS Dementia Complex; Animals; Blood-Brain Barrier; Brain; Case-Control Studies; Cell Adhesion; Cells, Cultured; Drug Evaluation, Preclinical; Encephalitis; Endothelial Cells; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Inflammation Mediators; Male; Mice; Mice, Inbred C57BL; Monocytes; Protein Kinase Inhibitors; Thiadiazoles; Thiazoles; Urea

2010
Rapid modulation of TRH and TRH-like peptide release in rat brain, pancreas, and testis by a GSK-3beta inhibitor.
    Peptides, 2010, Volume: 31, Issue:6

    Topics: Animals; Brain; Cerebellum; Corticosterone; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Male; Oligopeptides; Pancreas; Rats; Rats, Sprague-Dawley; Testis; Thiazoles; Thyrotropin-Releasing Hormone; Time Factors; Urea

2010
A kinesin signaling complex mediates the ability of GSK-3beta to affect mood-associated behaviors.
    Proceedings of the National Academy of Sciences of the United States of America, 2010, Jun-22, Volume: 107, Issue:25

    Topics: Affect; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antidepressive Agents; Bipolar Disorder; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; Kinesins; Lithium; Male; Mice; Microtubule-Associated Proteins; Models, Biological; Neuronal Plasticity; Receptors, AMPA; Synapses; Thiazoles; Urea

2010
The antinociceptive effects of AR-A014418, a selective inhibitor of glycogen synthase kinase-3 beta, in mice.
    The journal of pain, 2011, Volume: 12, Issue:3

    Topics: Abdominal Pain; Aggression; Analgesics; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azides; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Formaldehyde; Glutamic Acid; Glycogen Synthase Kinase 3; Inflammation; Male; Mice; N-Methylaspartate; Pain Measurement; Sugar Acids; Thiazoles; Urea; Xylose

2011
Glycogen synthase kinase-3β indirectly facilitates interferon-γ-induced nuclear factor-κB activation and nitric oxide biosynthesis.
    Journal of cellular biochemistry, 2010, Dec-15, Volume: 111, Issue:6

    Topics: Animals; Blotting, Western; Cell Line; Electrophoretic Mobility Shift Assay; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Indoles; Interferon-gamma; Mice; NF-kappa B; Nitric Oxide; Oximes; RNA Interference; Signal Transduction; Thiazoles; Urea

2010
Evidence for antimanic efficacy of glycogen synthase kinase-3 (GSK3) inhibitors in a strain-specific model of acute mania.
    The international journal of neuropsychopharmacology, 2011, Volume: 14, Issue:8

    Topics: Amphetamine; Animals; Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Blood-Brain Barrier; Central Nervous System Stimulants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Glycogen Synthase Kinase 3; Humans; Indoles; Male; Maleimides; Mice; Mice, Mutant Strains; Molecular Targeted Therapy; Motor Activity; Reproducibility of Results; Thiadiazoles; Thiazoles; Urea

2011
Characterization of the effect of TIMAP phosphorylation on its interaction with protein phosphatase 1.
    Biochimie, 2011, Volume: 93, Issue:7

    Topics: Animals; Blotting, Western; Cell Line; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cytoskeletal Proteins; Endothelial Cells; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Kinetics; Membrane Proteins; Microfilament Proteins; Microscopy, Fluorescence; Phosphorylation; Protein Binding; Protein Phosphatase 1; Surface Plasmon Resonance; Thiazoles; Urea

2011
Inhibition of glycogen synthase kinase-3 increases the cytotoxicity of enzastaurin.
    The Journal of investigative dermatology, 2011, Volume: 131, Issue:7

    Topics: Antineoplastic Agents; beta Catenin; Cells, Cultured; Glycogen Synthase Kinase 3; Humans; Hyaluronan Receptors; Indoles; Lymphoma, T-Cell, Cutaneous; Protein Kinase C; Protein Kinase Inhibitors; Skin Neoplasms; TCF Transcription Factors; Thiazoles; Urea

2011
Troglitazone, a PPAR agonist, inhibits human prostate cancer cell growth through inactivation of NFκB via suppression of GSK-3β expression.
    Cancer biology & therapy, 2011, Aug-15, Volume: 12, Issue:4

    Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Chromans; Dose-Response Relationship, Drug; G1 Phase; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Immunoblotting; Male; Microscopy, Fluorescence; NF-kappa B; PPAR gamma; Prostatic Neoplasms; Resting Phase, Cell Cycle; RNA Interference; Thiazoles; Thiazolidinediones; Troglitazone; Urea

2011
Synthesis and biological evaluation of glycogen synthase kinase 3 (GSK-3) inhibitors: an fast and atom efficient access to 1-aryl-3-benzylureas.
    Bioorganic & medicinal chemistry letters, 2011, Sep-15, Volume: 21, Issue:18

    Topics: Animals; Chemistry Techniques, Synthetic; Dose-Response Relationship, Drug; Glycogen Synthase Kinase 3; Microwaves; Models, Molecular; Molecular Structure; Phenotype; Protein Kinase Inhibitors; Small Molecule Libraries; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Urea; Zebrafish

2011
Glycogen synthase kinase 3β inhibition sensitizes pancreatic cancer cells to gemcitabine.
    Journal of gastroenterology, 2012, Volume: 47, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Cell Line, Tumor; Deoxycytidine; DNA Repair; Drug Resistance, Neoplasm; Female; Gemcitabine; Gene Expression Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; HEK293 Cells; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Oligonucleotide Array Sequence Analysis; Pancreatic Neoplasms; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Urea; Xenograft Model Antitumor Assays

2012
Towards the preparation of radiolabeled 1-aryl-3-benzyl ureas: Radiosynthesis of [(11)C-carbonyl] AR-A014418 by [(11)C]CO(2) fixation.
    Bioorganic & medicinal chemistry letters, 2012, Mar-01, Volume: 22, Issue:5

    Topics: Carbon Dioxide; Carbon Radioisotopes; Glycogen Synthase Kinase 3; Humans; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles; Urea

2012
Signalling through the type 1 insulin-like growth factor receptor (IGF1R) interacts with canonical Wnt signalling to promote neural proliferation in developing brain.
    ASN neuro, 2012, Jul-10, Volume: 4, Issue:5

    Topics: Adjuvants, Immunologic; Animals; beta Catenin; beta-Galactosidase; Brain; Cell Proliferation; Cells, Cultured; Embryo, Mammalian; Enzyme Inhibitors; Frontal Lobe; Gene Expression Regulation, Developmental; Lithium Chloride; Mice; Mice, Transgenic; Neurons; Receptor, IGF Type 1; RNA, Messenger; Signal Transduction; Thiazoles; Urea; Wnt Proteins

2012
Inhibition of GSK-3β reverses the pro-apoptotic effect of proadifen (SKF-525A) in HT-29 colon adenocarcinoma cells.
    Toxicology in vitro : an international journal published in association with BIBRA, 2012, Volume: 26, Issue:6

    Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Cycle; Cell Proliferation; Colonic Neoplasms; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; HT29 Cells; Humans; Proadifen; Protein Kinase Inhibitors; Thiazoles; Urea

2012
The neuroprotective effect of the GSK-3β inhibitor and influence on the extrinsic apoptosis in the ALS transgenic mice.
    Journal of the neurological sciences, 2012, Sep-15, Volume: 320, Issue:1-2

    Topics: Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Caspase 8; Cell Count; Disease Models, Animal; fas Receptor; Fas-Associated Death Domain Protein; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Mice; Mice, Transgenic; Motor Neurons; Neuroprotective Agents; Phosphorylation; Rotarod Performance Test; Signal Transduction; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1; Thiazoles; Urea

2012
Glycogen synthase kinase 3-specific inhibitor AR-A014418 decreases neuropathic pain in mice: evidence for the mechanisms of action.
    Neuroscience, 2012, Dec-13, Volume: 226

    Topics: Analgesics; Animals; Arginine; Cytokines; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Hyperalgesia; Ligation; Male; Mice; Motor Activity; Neuralgia; Nitric Oxide; Pain Measurement; Parasympathetic Nervous System; Sciatic Neuropathy; Serotonin; Spinal Cord; Thiazoles; Urea

2012
Cross-talk between glycogen synthase kinase 3β (GSK3β) and p38MAPK regulates myocyte enhancer factor 2 (MEF2) activity in skeletal and cardiac muscle.
    Journal of molecular and cellular cardiology, 2013, Volume: 54

    Topics: Animals; Cell Line; Enhancer Elements, Genetic; Female; Gene Expression Regulation; Genes, Reporter; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Imidazoles; Luciferases; Male; MEF2 Transcription Factors; Mice; Mice, Inbred C57BL; Mice, Transgenic; Muscle, Skeletal; Myoblasts; Myoblasts, Skeletal; Myocardium; Myocytes, Cardiac; Myogenic Regulatory Factors; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Primary Cell Culture; Protein Processing, Post-Translational; Pyridines; Signal Transduction; Thiazoles; Transcriptional Activation; Urea

2013
Glycogen synthase kinase-3 inhibition prevents learning deficits in diabetic mice.
    Journal of neuroscience research, 2013, Volume: 91, Issue:4

    Topics: Animals; Cerebral Cortex; Cognition Disorders; Diabetes Mellitus, Experimental; Female; Glycogen Synthase Kinase 3; Hippocampus; Maze Learning; Mice; Motor Skills; Nerve Growth Factors; Recognition, Psychology; Rotarod Performance Test; Thiazoles; Urea

2013
Glycogen synthase kinase-3β positively regulates protein synthesis and cell proliferation through the regulation of translation initiation factor 4E-binding protein 1.
    Oncogene, 2014, Mar-27, Volume: 33, Issue:13

    Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Cycle Proteins; Cell Growth Processes; Enzyme Inhibitors; Female; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Mice; Mice, Nude; Peptide Initiation Factors; Phosphoproteins; Phosphorylation; Protein Binding; Protein Biosynthesis; Random Allocation; Thiazoles; Triple Negative Breast Neoplasms; Urea; Xenograft Model Antitumor Assays

2014
Glycogen synthase kinase 3β inhibition as a therapeutic approach in the treatment of endometrial cancer.
    International journal of molecular sciences, 2013, Aug-12, Volume: 14, Issue:8

    Topics: Adjuvants, Immunologic; Animals; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Endometrial Neoplasms; Female; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Lithium Chloride; M Phase Cell Cycle Checkpoints; Mice; Neoplasm Transplantation; Paclitaxel; Signal Transduction; Thiazoles; Urea; Xenograft Model Antitumor Assays

2013
Identification of glycogen synthase kinase 3α as a therapeutic target in melanoma.
    Pigment cell & melanoma research, 2013, Volume: 26, Issue:6

    Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Down-Regulation; G1 Phase; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Melanocytes; Melanoma; Molecular Targeted Therapy; Neoplasm Staging; Resting Phase, Cell Cycle; RNA, Small Interfering; Skin Neoplasms; Thiazoles; Urea; Xenograft Model Antitumor Assays

2013
Glycogen synthase kinase 3 beta regulates glial glutamate transporter protein expression in the spinal dorsal horn in rats with neuropathic pain.
    Experimental neurology, 2014, Volume: 252

    Topics: Amino Acid Transport System X-AG; Animals; Astrocytes; Disease Models, Animal; Drug Administration Routes; Enzyme Inhibitors; Excitatory Amino Acid Transporter 2; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hyperalgesia; Interleukin-1beta; Male; Neurons; Oncogene Protein v-akt; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Sciatica; Serine; Spinal Cord; Thiazoles; Time Factors; Urea

2014
Persistent Wnt/β-catenin signaling determines dorsalization of the postnatal subventricular zone and neural stem cell specification into oligodendrocytes and glutamatergic neurons.
    Stem cells (Dayton, Ohio), 2014, Volume: 32, Issue:5

    Topics: Animals; beta Catenin; Blotting, Western; Cell Proliferation; Glutamic Acid; Glycogen Synthase Kinase 3; Green Fluorescent Proteins; Lateral Ventricles; Mice, Transgenic; Microscopy, Confocal; Neural Stem Cells; Neurons; Oligodendroglia; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Thiazoles; Urea; Wnt3 Protein

2014
Specific glycogen synthase kinase-3 inhibition reduces neuroendocrine markers and suppresses neuroblastoma cell growth.
    Cancer biology & therapy, 2014, Volume: 15, Issue:5

    Topics: Antineoplastic Agents; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Biomarkers, Tumor; Bone Marrow Neoplasms; Cell Line, Tumor; Cell Proliferation; Chromogranin A; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Neuroblastoma; Phosphorylation; Thiazoles; Tyrosine; Urea

2014
New methods to control neuroblastoma growth.
    Cancer biology & therapy, 2014, Volume: 15, Issue:5

    Topics: Antineoplastic Agents; Biomarkers, Tumor; Bone Marrow Neoplasms; Cell Proliferation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Neuroblastoma; Thiazoles; Urea

2014
Signal transducers and activators of transcription 3-induced metastatic potential in gastric cancer cells is enhanced by glycogen synthase kinase-3β.
    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 2015, Volume: 123, Issue:5

    Topics: Amino Acid Substitution; Biomarkers, Tumor; Cell Line, Tumor; Cell Movement; Epithelial-Mesenchymal Transition; Gene Knockdown Techniques; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Immunohistochemistry; Mutant Proteins; Neoplasm Invasiveness; RNA, Small Interfering; Signal Transduction; STAT3 Transcription Factor; Stomach Neoplasms; Thiazoles; Tyrphostins; Urea

2015
Inhibition of invasion by glycogen synthase kinase-3 beta inhibitors through dysregulation of actin re-organisation via down-regulation of WAVE2.
    Biochemical and biophysical research communications, 2015, Aug-14, Volume: 464, Issue:1

    Topics: Actin Cytoskeleton; Actins; Cell Adhesion; Cell Line, Tumor; Cell Movement; Collagen; Drug Combinations; Focal Adhesions; Gene Expression; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Laminin; Protein Kinase Inhibitors; Proteoglycans; Thiazoles; Urea; Wiskott-Aldrich Syndrome Protein Family

2015
Potential Role of Glycogen Synthase Kinase-3β in Regulation of Myocardin Activity in Human Vascular Smooth Muscle Cells.
    Journal of cellular physiology, 2016, Volume: 231, Issue:2

    Topics: Actins; Calcium-Binding Proteins; Calponins; Cell Differentiation; Cell Line; Gene Expression Regulation; Gene Knockout Techniques; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Membrane Proteins; Microfilament Proteins; Muscle Proteins; Myocytes, Smooth Muscle; Nuclear Proteins; Phosphoproteins; Promoter Regions, Genetic; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Recombinant Proteins; RNA, Small Interfering; Serine; Thiazoles; Threonine; Trans-Activators; Urea

2016
Glycogen synthase kinase-3 inhibitor AR-A014418 suppresses pancreatic cancer cell growth via inhibition of GSK-3-mediated Notch1 expression.
    HPB : the official journal of the International Hepato Pancreato Biliary Association, 2015, Volume: 17, Issue:9

    Topics: Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Survival; Glycogen Synthase Kinase 3; Humans; Immunoprecipitation; Pancreas; Pancreatic Neoplasms; Receptor, Notch1; Thiazoles; Urea

2015
Inhibition of glycogen synthase kinase-3 beta induces apoptosis and mitotic catastrophe by disrupting centrosome regulation in cancer cells.
    Scientific reports, 2015, Aug-21, Volume: 5

    Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Centrosome; Chromosomal Instability; Down-Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Mitosis; Neoplasms; NF-kappa B; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Spindle Apparatus; Thiazoles; Urea

2015
Investigations on GSK-3β/NF-kB signaling in stress and stress adaptive behavior in electric foot shock subjected mice.
    Behavioural brain research, 2016, Apr-01, Volume: 302

    Topics: Adaptation, Psychological; Adjuvants, Immunologic; Animals; Brain; Corticosterone; Disease Models, Animal; Ditiocarb; Dose-Response Relationship, Drug; Electroshock; Enzyme Inhibitors; Exploratory Behavior; Gene Expression Regulation; Glycogen Synthase Kinase 3 beta; Interpersonal Relations; Locomotion; Mice; NF-kappa B; Signal Transduction; Stress, Psychological; Thiazoles; Urea

2016
Cholinergic Surveillance over Hippocampal RNA Metabolism and Alzheimer's-Like Pathology.
    Cerebral cortex (New York, N.Y. : 1991), 2017, 07-01, Volume: 27, Issue:7

    Topics: Acetylcholine; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Cells, Cultured; Disease Models, Animal; Embryo, Mammalian; Enzyme Inhibitors; Gene Expression Regulation; Glycogen Synthase Kinase 3; Hippocampus; Humans; Learning Disabilities; Mice; Mice, Inbred C57BL; Mice, Transgenic; RNA; Thiazoles; Thyroid Nuclear Factor 1; Urea; Vesicular Acetylcholine Transport Proteins

2017
Lithium and valproate act on the GSK-3β signaling pathway to reverse manic-like behavior in an animal model of mania induced by ouabain.
    Neuropharmacology, 2017, 05-01, Volume: 117

    Topics: Animals; Antimanic Agents; Bipolar Disorder; Disease Models, Animal; Frontal Lobe; Glycogen Synthase Kinase 3 beta; Hippocampus; Lithium Compounds; Locomotion; Male; Ouabain; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats, Wistar; Signal Transduction; Thiazoles; Urea; Valproic Acid

2017
Angiotensin II degrades myeloid cell leukemia 1 in human umbilical vein endothelial cells.
    IUBMB life, 2017, Volume: 69, Issue:5

    Topics: Angiotensin II; Cell Survival; Dose-Response Relationship, Drug; Glycogen Synthase Kinase 3; Human Umbilical Vein Endothelial Cells; Humans; Myeloid Cell Leukemia Sequence 1 Protein; Phosphorylation; Thiazoles; Urea

2017
Using gene expression database to uncover biology functions of 1,4-disubstituted 1,2,3-triazole analogues synthesized via a copper (I)-catalyzed reaction.
    European journal of medicinal chemistry, 2017, May-26, Volume: 132

    Topics: Antineoplastic Agents; Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Line, Tumor; Copper; Curcumin; Databases, Genetic; Glycogen Synthase Kinase 3; Humans; Liver Neoplasms; Structure-Activity Relationship; Thiazoles; Triazoles; Urea

2017
Glycogen synthase kinase 3β inhibitors prevent hepatitis C virus release/assembly through perturbation of lipid metabolism.
    Scientific reports, 2017, 05-31, Volume: 7, Issue:1

    Topics: Apolipoproteins B; Apolipoproteins E; Cell Line; Glycogen Synthase Kinase 3 beta; Hepacivirus; Hepatitis C; Humans; Lipid Metabolism; Lithium Chloride; Thiazoles; Urea; Virion; Virus Replication

2017
Anti-stress effects of a GSK-3β inhibitor, AR-A014418, in immobilization stress of variable duration in mice.
    Journal of basic and clinical physiology and pharmacology, 2017, Jul-26, Volume: 28, Issue:4

    Topics: Animals; Behavior, Animal; Brain; Corticosterone; Disease Models, Animal; Glycogen Synthase Kinase 3 beta; Mice; Motor Activity; Stress, Psychological; Thiazoles; Urea

2017
GSK3 inhibitor AR-A014418 promotes osteogenic differentiation of human adipose-derived stem cells via ERK and mTORC2/Akt signaling pathway.
    Biochemical and biophysical research communications, 2017, 08-19, Volume: 490, Issue:2

    Topics: Adipose Tissue; Butadienes; Cell Differentiation; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Humans; Mechanistic Target of Rapamycin Complex 2; Multiprotein Complexes; Nitriles; Osteogenesis; Proto-Oncogene Proteins c-akt; Signal Transduction; Stem Cells; Structure-Activity Relationship; Thiazoles; TOR Serine-Threonine Kinases; Urea

2017
GSK3α/β: A Novel Therapeutic Target for Neuroendocrine Tumors.
    Neuroendocrinology, 2018, Volume: 106, Issue:4

    Topics: Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Glycogen Synthase Kinase 3 beta; Humans; Neuroendocrine Tumors; Thiazoles; Urea

2018
Glycogen synthase kinase-3β inhibition promotes lysosome-dependent degradation of c-FLIP
    Cell death & disease, 2018, 02-14, Volume: 9, Issue:2

    Topics: Amino Acid Sequence; AMP-Activated Protein Kinases; Apoptosis; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 3; Cell Line, Tumor; Cell Nucleus; Cytoskeletal Proteins; Cytosol; Gene Expression Regulation; Hep G2 Cells; Humans; Lysosomes; Nuclear Proteins; Protein Stability; Proteolysis; RNA, Small Interfering; Signal Transduction; Thiazoles; TOR Serine-Threonine Kinases; Urea

2018
Glycogen synthase kinase-3β inhibition enhances myelination in preterm newborns with intraventricular hemorrhage, but not recombinant Wnt3A.
    Neurobiology of disease, 2018, Volume: 118

    Topics: Animals; Brain; Female; Glycogen Synthase Kinase 3 beta; Humans; Infant, Newborn; Infant, Premature; Male; Nerve Fibers, Myelinated; Rabbits; Recombinant Proteins; Thiazoles; Urea; Wnt3A Protein

2018
Inhibition of GSK-3β on Behavioral Changes and Oxidative Stress in an Animal Model of Mania.
    Molecular neurobiology, 2019, Volume: 56, Issue:4

    Topics: Aldehydes; Animals; Antioxidants; Behavior, Animal; Bipolar Disorder; Catalase; Dinoprost; Disease Models, Animal; Glutathione Peroxidase; Glycogen Synthase Kinase 3 beta; Lipid Peroxidation; Male; Motor Activity; Oxidative Stress; Protein Carbonylation; Rats, Wistar; Submitochondrial Particles; Superoxide Dismutase; Superoxides; Thiazoles; Tyrosine; Urea

2019
Focused Ultrasound-Induced Blood-Brain Barrier Opening Enhances GSK-3 Inhibitor Delivery for Amyloid-Beta Plaque Reduction.
    Scientific reports, 2018, 08-27, Volume: 8, Issue:1

    Topics: Amyloid beta-Peptides; Animals; Biomarkers; Blood-Brain Barrier; Brain; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Immunohistochemistry; Male; Mice; Mice, Transgenic; Plaque, Amyloid; Protein Aggregates; Protein Aggregation, Pathological; Protein Binding; Thiazoles; Ultrasonic Waves; Urea

2018
GSK3β Inhibition Restores Impaired Neurogenesis in Preterm Neonates With Intraventricular Hemorrhage.
    Cerebral cortex (New York, N.Y. : 1991), 2019, 07-22, Volume: 29, Issue:8

    Topics: Animals; Apoptosis; Blotting, Western; Case-Control Studies; Cell Count; Cell Proliferation; Cerebral Cortex; Cerebral Intraventricular Hemorrhage; Disease Models, Animal; Ependymoglial Cells; Glycogen Synthase Kinase 3 beta; Humans; Immunohistochemistry; Infant, Extremely Premature; Infant, Newborn; Ki-67 Antigen; Lateral Ventricles; Neural Stem Cells; Neurogenesis; PAX6 Transcription Factor; Phosphorylation; Pyramidal Cells; Rabbits; Real-Time Polymerase Chain Reaction; Retinoblastoma Protein; SOXB1 Transcription Factors; T-Box Domain Proteins; Thiazoles; Urea; White Matter

2019
The chemokine CXCL1 and its receptor CXCR2 contribute to chronic stress-induced depression in mice.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019, Volume: 33, Issue:8

    Topics: Animals; Antidepressive Agents, Second-Generation; Apoptosis; Brain-Derived Neurotrophic Factor; Chemokine CXCL1; Depression; Fluoxetine; Glycogen Synthase Kinase 3 beta; Hippocampus; Male; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Phenylurea Compounds; Receptors, Interleukin-8B; Stress, Psychological; Thiazoles; Triazoles; Urea

2019
Glycogen synthase kinase 3β as a potential therapeutic target in synovial sarcoma and fibrosarcoma.
    Cancer science, 2020, Volume: 111, Issue:2

    Topics: Animals; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin D1; Cyclin-Dependent Kinase 4; Fibrosarcoma; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3 beta; Humans; Indoles; Injections, Intraperitoneal; Maleimides; Mice; Phosphorylation; RNA Interference; Sarcoma, Synovial; Thiazoles; Up-Regulation; Urea; Xenograft Model Antitumor Assays

2020
GSK3β suppression inhibits MCL1 protein synthesis in human acute myeloid leukemia cells.
    Journal of cellular physiology, 2021, Volume: 236, Issue:1

    Topics: Aniline Compounds; Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Glycogen Synthase Kinase 3 beta; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; MAP Kinase Signaling System; Myeloid Cell Leukemia Sequence 1 Protein; RNA, Messenger; Sulfonamides; Thiazoles; U937 Cells; Urea

2021
The involvement of PI3K/Akt/mTOR/GSK3β signaling pathways in the antidepressant-like effect of AZD6765.
    Pharmacology, biochemistry, and behavior, 2020, Volume: 198

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Drug Combinations; Female; Glycogen Synthase Kinase 3 beta; Hindlimb Suspension; Hippocampus; Ketamine; Lithium Chloride; Mice; Open Field Test; Phenethylamines; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridines; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Stress, Physiological; Thiazoles; TOR Serine-Threonine Kinases; Urea

2020