Page last updated: 2024-08-21

thiazoles and mkt 077

thiazoles has been researched along with mkt 077 in 39 studies

Research

Studies (39)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	11 (28.21)	18.2507
2000's	10 (25.64)	29.6817
2010's	14 (35.90)	24.3611
2020's	4 (10.26)	2.80

Authors

Authors	Studies
Chen, LB; Kawakami, M; Koya, K; Li, Y; Tatsuta, N; Ukai, T; Wang, H	1
Brunelli, BT; Chen, LB; Koya, K; Li, Y; Modica-Napolitano, JS; Weisberg, E	1
Chen, LB; Koya, K; Li, Y; Modica-Napolitano, J; Weisberg, EL	1
Brunelli, BT; Chen, LB; Koya, K; Modica-Napolitano, JS	1
Chiba, Y; Kitajima, M; Koya, K; Kubota, T; Matsumoto, Y; Otani, Y; Teramoto, T; Watanabe, M	1
Chen, LB; Kawakami, M; Koya, K; Kuroiwa, H; Mochizuki, T; Motoji, N; Shigematsu, A; Shishido, T; Suzuki, N; Tatsuta, N	1
Izbicka, E; Lawrence, RA; Nalin, C; Petit, T; Von Hoff, DD; Weitman, SD	1
Naasani, I; Seimiya, H; Tsuruo, T; Yamori, T	1
Braybrooke, JP; Collins, WC; Cramer, JA; Ganesan, TS; Harris, AL; Levitt, NC; Lodi, R; Propper, DJ; Styles, P; Talbot, DC; Taylor, DJ	1
Baker, SD; Britten, CD; Collins, W; Cramer, J; Eckhardt, SG; Rothenberg, M; Rowinsky, EK; Smetzer, L; Smith, L; Stephenson, J; Von Hoff, DD; Weiss, GR	1
Maruta, H; Shakri, R; Shishido, T; Tikoo, A	1
Chen, LB; Kawakami, M; Koya, K; Shishido, T; Suzuki, N; Tatsuta, N	1
Kaul, SC; Maruta, H; Nomura, H; Reddel, RR; Simpson, R; Sugihara, T; Wadhwa, R; Yoshida, A	1
Ihara, M; Inoue, H; Kim, HS; Shishido, T; Suzuki, M; Takasu, K; Wataya, Y	1
Colgin, L; Kaul, SC; Reddel, RR; Taira, K; Wadhwa, R; Yaguchi, T	1
Kaul, SC; Taira, K; Wadhwa, R	1
Kidd, ME; Modica-Napolitano, JS; Nalbandian, A; Nalbandian, R; Nguyen, CC	1
Cooper, JM; Gu, M; Hartley, JA; Hochhauser, D; Lo, S; Schapira, AH; Taanman, JW; Tolner, B	1
Böttger, S; Low, B; Walker, C	1
Deocaris, CC; Kaul, SC; Kaur, K; Ohtaka, M; Shrestha, BG; Wadhwa, R; Widodo, N; Yamasaki, K	1
Böttger, SA; Walker, CW	1
Fishelson, Z; Koya, K; Pilzer, D; Saar, M	1
Binaglia, L; Calabresi, P; Chiasserini, D; de Iure, A; Koya, K; Orvietani, PL; Susta, F; Tantucci, M; Tozzi, A	1
Dickey, CA; Gestwicki, JE; Jinwal, UK; Miyata, Y; Rousaki, A; Zuiderweg, ER	1
Braun, RD; Chunta, JL; Vistisen, KS; Yazdi, Z	1
Chua, JP; Collins, CA; Gestwicki, JE; Klinedinst, S; Komiyama, T; Li, X; Lieberman, AP; Merry, DE; Miyata, Y; Morishima, Y; Osawa, Y; Peng, HM; Pratt, WB; Wang, AM	1
Brodsky, JL; Dickey, CA; Gestwicki, JE; Jinwal, UK; Lee, HF; Li, X; Miyata, Y; Seguin, SP; Srinivasan, SR; Sun, D; Young, ZT	1
Balaburski, GM; Beeharry, N; Bondar, A; Budina-Kolomets, A; Murphy, ME; Yen, T	1
Ariga, H; Matsuoka, S; Suda, T; Tai-Nagara, I	1
E, Q; Gao, P; Guo, W; Liu, W; Liu, X; Yan, L; Yang, L; Ye, X; Zuo, J	1
Bhargava, P; Kaul, SC; Lee, JS; Na, Y; Ryu, J; Wadhwa, R; Yun, CO	1
Kim, S; Krysiak, K; Liu, T; Ndonwi, M; Shao, J; Shirai, CL; Walter, MJ	1
Ben-Hamo, O; Oren, M; Rabinowitz, C; Rinkevich, B; Rosner, A	1
Assimon, VA; Colombo, G; Gestwicki, JE; Morra, G; Rinaldi, S; Shao, H; Taylor, IR; Young, ZT	1
Brustolin, M; Kuchipudi, SV; Macias, VM; Nissly, RH; Nomura, M; Pujhari, S; Rasgon, JL	1
Fazal, F; Leonard, A; Rahman, A; Su, PY; Yule, DI	1
Cui, M; Lin, Z; Wang, X; Xu, M; Zhang, Y	1
Beer, L; Dhamad, AE; Dridi, S; Greene, E; Liyanage, R; Nguyen, P; Sales, M	1
Gestwicki, JE; Hong, SK; Johnson, OT; Park, JI; Starenki, D	1

Reviews

2 review(s) available for thiazoles and mkt 077

Article	Year
Mortalin: a potential candidate for biotechnology and biomedicine. Histology and histopathology, 2002, Volume: 17, Issue:4 Topics: Animals; Biotechnology; Carrier Proteins; Genes, p53; HSP70 Heat-Shock Proteins; Humans; Mice; Mitochondrial Proteins; Pyridines; Thiazoles	2002
A naturally occurring cancer with molecular connectivity to human diseases. Cell cycle (Georgetown, Tex.), 2008, Volume: 7, Issue:15 Topics: Animal Diseases; Animals; Antineoplastic Agents; Apoptosis; Brachyura; Disease; Disease Models, Animal; DNA Damage; Drug Evaluation, Preclinical; HSP70 Heat-Shock Proteins; Humans; Molecular Sequence Data; Neoplasms; Pyridines; Signal Transduction; Thiazoles; Tumor Suppressor Protein p53	2008

Article

Year

Mortalin: a potential candidate for biotechnology and biomedicine.

Histology and histopathology, 2002, Volume: 17, Issue:4

Topics: Animals; Biotechnology; Carrier Proteins; Genes, p53; HSP70 Heat-Shock Proteins; Humans; Mice; Mitochondrial Proteins; Pyridines; Thiazoles

2002

A naturally occurring cancer with molecular connectivity to human diseases.

Cell cycle (Georgetown, Tex.), 2008, Volume: 7, Issue:15

Topics: Animal Diseases; Animals; Antineoplastic Agents; Apoptosis; Brachyura; Disease; Disease Models, Animal; DNA Damage; Drug Evaluation, Preclinical; HSP70 Heat-Shock Proteins; Humans; Molecular Sequence Data; Neoplasms; Pyridines; Signal Transduction; Thiazoles; Tumor Suppressor Protein p53

2008

Trials

2 trial(s) available for thiazoles and mkt 077

Article	Year
Phase I trial of the selective mitochondrial toxin MKT077 in chemo-resistant solid tumours. Annals of oncology : official journal of the European Society for Medical Oncology, 1999, Volume: 10, Issue:8 Topics: Adult; Aged; Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Monitoring; Drug Resistance, Neoplasm; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Male; Middle Aged; Mitochondria; Neoplasm Staging; Neoplasms; Pyridines; Severity of Illness Index; Thiazoles; Treatment Outcome	1999
A phase I and pharmacokinetic study of the mitochondrial-specific rhodacyanine dye analog MKT 077. Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:1 Topics: Adult; Aged; Antineoplastic Agents; Area Under Curve; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Magnesium; Male; Metabolic Clearance Rate; Middle Aged; Mitochondria; Neoplasms; Proteinuria; Pyridines; Thiazoles; Tissue Distribution	2000

Article

Year

Phase I trial of the selective mitochondrial toxin MKT077 in chemo-resistant solid tumours.

Annals of oncology : official journal of the European Society for Medical Oncology, 1999, Volume: 10, Issue:8

Topics: Adult; Aged; Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Monitoring; Drug Resistance, Neoplasm; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Male; Middle Aged; Mitochondria; Neoplasm Staging; Neoplasms; Pyridines; Severity of Illness Index; Thiazoles; Treatment Outcome

1999

A phase I and pharmacokinetic study of the mitochondrial-specific rhodacyanine dye analog MKT 077.

Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:1

Topics: Adult; Aged; Antineoplastic Agents; Area Under Curve; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Magnesium; Male; Metabolic Clearance Rate; Middle Aged; Mitochondria; Neoplasms; Proteinuria; Pyridines; Thiazoles; Tissue Distribution

2000

Other Studies

35 other study(ies) available for thiazoles and mkt 077

Article	Year
MKT-077, a novel rhodacyanine dye in clinical trials, exhibits anticarcinoma activity in preclinical studies based on selective mitochondrial accumulation. Cancer research, 1996, Feb-01, Volume: 56, Issue:3 Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Chlorocebus aethiops; Cisplatin; Doxorubicin; Drug Screening Assays, Antitumor; Ethanol; Female; Flow Cytometry; Humans; Kidney; Male; Mice; Mice, Nude; Microscopy, Confocal; Microscopy, Video; Mitochondria; Neoplasm Transplantation; Neoplasms; Pyridines; Solubility; Thiazoles; Tumor Cells, Cultured	1996
Selective damage to carcinoma mitochondria by the rhodacyanine MKT-077. Cancer research, 1996, Feb-01, Volume: 56, Issue:3 Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chlorocebus aethiops; DNA, Mitochondrial; Electron Transport; Epithelium; Humans; Male; Microscopy, Electron; Mitochondria, Liver; Neoplasms; Oxygen Consumption; Pyridines; Rats; Rats, Sprague-Dawley; Thiazoles; Tumor Cells, Cultured	1996
In vivo administration of MKT-077 causes partial yet reversible impairment of mitochondrial function. Cancer research, 1996, Feb-01, Volume: 56, Issue:3 Topics: Animals; Antineoplastic Agents; Base Sequence; Body Weight; DNA, Mitochondrial; Female; Kidney; Mitochondria; Mitochondria, Heart; Mitochondria, Liver; Molecular Sequence Data; Oxygen Consumption; Pyridines; Rats; Rats, Sprague-Dawley; Thiazoles	1996
Photoactivation enhances the mitochondrial toxicity of the cationic rhodacyanine MKT-077. Cancer research, 1998, Jan-01, Volume: 58, Issue:1 Topics: Animals; Antineoplastic Agents; Cells, Cultured; DNA, Mitochondrial; Electron Transport Complex IV; Haplorhini; Light; Lipid Peroxidation; Male; Mitochondria; NADH Dehydrogenase; Oxygen Consumption; Pyridines; Rats; Rats, Sprague-Dawley; Succinic Acid; Thiazoles	1998
Selective antitumor activity of MKT-077, a delocalized lipophilic cation, on normal cells and cancer cells in vitro. Journal of surgical oncology, 1998, Volume: 69, Issue:2 Topics: Antineoplastic Agents; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Humans; In Vitro Techniques; Inhibitory Concentration 50; Male; Pancreatic Neoplasms; Pyridines; Spleen; Stomach Neoplasms; Thiazoles; Tumor Cells, Cultured	1998
Pharmacokinetic analysis and antitumor efficacy of MKT-077, a novel antitumor agent. Cancer chemotherapy and pharmacology, 1999, Volume: 43, Issue:4 Topics: Animals; Antineoplastic Agents; Autoradiography; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Colonic Neoplasms; Female; Half-Life; Humans; Male; Metabolic Clearance Rate; Mice; Mice, Nude; Pyridines; Thiazoles; Tissue Distribution; Transplantation, Heterologous	1999
Activity of MKT 077, a rhodacyanine dye, against human tumor colony-forming units. Anti-cancer drugs, 1999, Volume: 10, Issue:3 Topics: Antineoplastic Agents; Drug Screening Assays, Antitumor; Humans; Pyridines; Rhodamine 123; Thiazoles; Tumor Cells, Cultured	1999
FJ5002: a potent telomerase inhibitor identified by exploiting the disease-oriented screening program with COMPARE analysis. Cancer research, 1999, Aug-15, Volume: 59, Issue:16 Topics: Antineoplastic Agents; Databases, Factual; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Pyridines; Telomerase; Thiazoles	1999
The anti-RAS cancer drug MKT-077 is an F-actin cross-linker. Annals of the New York Academy of Sciences, 1999, Volume: 886 Topics: 3T3 Cells; Actins; Animals; Antineoplastic Agents; Cell Division; Cell Line; Cell Line, Transformed; Mice; Oncogene Protein p21(ras); Pyridines; Thiazoles	1999
Determination of MKT-077, a novel antineoplastic agent, in plasma samples by high-performance liquid chromatography and its application to pharmacokinetics in rats. Journal of pharmaceutical and biomedical analysis, 1999, Volume: 19, Issue:3-4 Topics: Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Evaluation Studies as Topic; Female; Pyridines; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Thiazoles	1999
Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function. Cancer research, 2000, Dec-15, Volume: 60, Issue:24 Topics: 3T3 Cells; Animals; Antineoplastic Agents; Chromatography, Affinity; Coloring Agents; Cytoplasm; Genes, Reporter; HSP70 Heat-Shock Proteins; Humans; Mice; Microscopy, Fluorescence; Mitochondrial Proteins; Precipitin Tests; Protein Binding; Pyridines; Thiazoles; Transcriptional Activation; Transfection; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2000
Rhodacyanine dyes as antimalarials. 1. Preliminary evaluation of their activity and toxicity. Journal of medicinal chemistry, 2002, Feb-28, Volume: 45, Issue:5 Topics: Animals; Antimalarials; Coloring Agents; Plasmodium falciparum; Pyridines; Structure-Activity Relationship; Thiazoles	2002
Rhodacyanine dye MKT-077 inhibits in vitro telomerase assay but has no detectable effects on telomerase activity in vivo. Cancer research, 2002, Aug-01, Volume: 62, Issue:15 Topics: Cell Division; Cell Line, Transformed; Coloring Agents; Enzyme Inhibitors; HSP70 Heat-Shock Proteins; Humans; Mitochondrial Proteins; Neoplasms; Pyridines; ras Proteins; Telomerase; Telomere; Thiazoles; Tumor Suppressor Protein p53	2002
The selective in vitro cytotoxicity of carcinoma cells by AZT is enhanced by concurrent treatment with delocalized lipophilic cations. Cancer letters, 2003, Jul-30, Volume: 198, Issue:1 Topics: Adenosine Triphosphate; Carcinoma; Cations; Cell Survival; Colony-Forming Units Assay; Humans; Male; Pyridines; Thiazoles; Thymidine; Tumor Cells, Cultured; Zidovudine	2003
Assessment of the significance of mitochondrial DNA damage by chemotherapeutic agents. International journal of oncology, 2005, Volume: 27, Issue:2 Topics: Antigens, Neoplasm; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; Blotting, Southern; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Daunorubicin; DNA Damage; DNA Topoisomerases, Type II; DNA-Binding Proteins; DNA, Mitochondrial; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Immunoblotting; Inhibitory Concentration 50; Intracellular Membranes; Membrane Potentials; Pyridines; Thiazoles; Tumor Suppressor Protein p53	2005
Mortalin-based cytoplasmic sequestration of p53 in a nonmammalian cancer model. The American journal of pathology, 2006, Volume: 168, Issue:5 Topics: Animals; Cytosol; Disease Models, Animal; Hemocytes; HSP70 Heat-Shock Proteins; Immunohistochemistry; Immunoprecipitation; Leukemia; Molecular Sequence Data; Mya; Neoplasms; Pyridines; Subcellular Fractions; Thiazoles; Tumor Suppressor Protein p53	2006
Mortalin sensitizes human cancer cells to MKT-077-induced senescence. Cancer letters, 2007, Jul-18, Volume: 252, Issue:2 Topics: Blotting, Western; Cell Line, Tumor; Cellular Senescence; Circular Dichroism; Dose-Response Relationship, Drug; HSP70 Heat-Shock Proteins; Humans; Pyridines; Spectrophotometry, Ultraviolet; Thiazoles	2007
Mortalin inhibitors sensitize K562 leukemia cells to complement-dependent cytotoxicity. International journal of cancer, 2010, Mar-15, Volume: 126, Issue:6 Topics: Animals; Bacterial Proteins; Blotting, Western; Calcimycin; Cell Survival; Complement C9; Dose-Response Relationship, Drug; HCT116 Cells; Hemolysis; HSP70 Heat-Shock Proteins; Humans; Ionophores; K562 Cells; Leukemia, Erythroblastic, Acute; Pyridines; Rabbits; Recombinant Proteins; RNA Interference; Streptolysins; Thiazoles	2010
Mortalin inhibition in experimental Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society, 2011, Aug-01, Volume: 26, Issue:9 Topics: Action Potentials; Animals; Antiparasitic Agents; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electron Transport Complex I; Gene Expression Regulation; HSP70 Heat-Shock Proteins; In Vitro Techniques; Male; Neurons; Oxidopamine; Parkinson Disease; Proteomics; Pyridines; Rats; Rats, Wistar; Thiazoles	2011
Allosteric drugs: the interaction of antitumor compound MKT-077 with human Hsp70 chaperones. Journal of molecular biology, 2011, Aug-19, Volume: 411, Issue:3 Topics: Binding Sites; Escherichia coli; HSC70 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Humans; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Chaperones; Molecular Dynamics Simulation; Protein Binding; Protein Structure, Quaternary; Pyridines; Thiazoles	2011
Uptake rate of cationic mitochondrial inhibitor MKT-077 determines cellular oxygen consumption change in carcinoma cells. PloS one, 2012, Volume: 7, Issue:5 Topics: Adenocarcinoma; Animals; Breast Neoplasms; Cell Line, Tumor; Female; Humans; Kinetics; Mammary Neoplasms, Animal; Mathematical Concepts; Mitochondria; Oxygen Consumption; Pyridines; Rats; Thiazoles	2012
Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation. Nature chemical biology, 2013, Volume: 9, Issue:2 Topics: Animals; Dose-Response Relationship, Drug; Doxorubicin; Drosophila; Female; HEK293 Cells; HeLa Cells; HSP70 Heat-Shock Proteins; Humans; Inhibitory Concentration 50; Models, Chemical; Molecular Chaperones; Muscular Disorders, Atrophic; Neurotoxins; PC12 Cells; Peptides; Protein Structure, Tertiary; Proteins; Pyridines; Rats; Receptors, Androgen; Thiazoles; Ubiquitination	2013
Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels. ACS chemical neuroscience, 2013, Jun-19, Volume: 4, Issue:6 Topics: Animals; Benzothiazoles; Blood-Brain Barrier; Capillary Permeability; Cells, Cultured; Drug Evaluation, Preclinical; Female; HSP70 Heat-Shock Proteins; Humans; MCF-7 Cells; Mice; Microsomes, Liver; Pyridines; tau Proteins; Thiazoles; Thiazolidines	2013
Comparison of the activity of three different HSP70 inhibitors on apoptosis, cell cycle arrest, autophagy inhibition, and HSP90 inhibition. Cancer biology & therapy, 2014, Volume: 15, Issue:2 Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Apoptosis; Autophagy; Cell Cycle Checkpoints; Cell Line, Tumor; HSP70 Heat-Shock Proteins; Humans; Purine Nucleosides; Pyridines; Sulfonamides; Thiazoles	2014
Mortalin and DJ-1 coordinately regulate hematopoietic stem cell function through the control of oxidative stress. Blood, 2014, Jan-02, Volume: 123, Issue:1 Topics: Animals; Antioxidants; Carrier Proteins; Cell Cycle; Colony-Forming Units Assay; Flow Cytometry; Gene Expression Regulation; Hematopoietic Stem Cells; HSP70 Heat-Shock Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Oncogene Proteins; Oxidative Stress; Peroxiredoxins; Protein Deglycase DJ-1; Pyridines; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles	2014
Targeting GRP75 improves HSP90 inhibitor efficacy by enhancing p53-mediated apoptosis in hepatocellular carcinoma. PloS one, 2014, Volume: 9, Issue:1 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzoquinones; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Female; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Liver Neoplasms; Membrane Proteins; Mice; Mice, Nude; Protein Transport; Pyridines; Thiazoles; Tumor Suppressor Protein p53	2014
Relevance of mortalin to cancer cell stemness and cancer therapy. Scientific reports, 2017, 02-06, Volume: 7 Topics: Antineoplastic Agents; Biomarkers, Tumor; Caffeic Acids; Cell Line; Cell Line, Tumor; HSP70 Heat-Shock Proteins; Humans; Neoplasms; Neoplastic Stem Cells; Phenylethyl Alcohol; Pyridines; RNA, Small Interfering; Thiazoles; Up-Regulation	2017
Knockdown of HSPA9 induces TP53-dependent apoptosis in human hematopoietic progenitor cells. PloS one, 2017, Volume: 12, Issue:2 Topics: Apoptosis; bcl-2-Associated X Protein; Biomarkers; Drug Resistance; Gene Expression; Gene Expression Regulation; Gene Knockdown Techniques; Hematopoietic Stem Cells; HSP70 Heat-Shock Proteins; Humans; Mitochondrial Proteins; Myelodysplastic Syndromes; Pyridines; RNA, Messenger; Thiazoles; Tumor Suppressor Protein p53	2017
Coupling astogenic aging in the colonial tunicate Botryllus schlosseri with the stress protein mortalin. Developmental biology, 2018, 01-01, Volume: 433, Issue:1 Topics: Age Factors; Aging; Animals; Apoptosis; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Pyridines; Reproduction, Asexual; Thiazoles; Urochordata	2018
A Local Allosteric Network in Heat Shock Protein 70 (Hsp70) Links Inhibitor Binding to Enzyme Activity and Distal Protein-Protein Interactions. ACS chemical biology, 2018, 11-16, Volume: 13, Issue:11 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Allosteric Regulation; Antineoplastic Agents; Binding Sites; HSC70 Heat-Shock Proteins; Humans; Molecular Dynamics Simulation; Protein Binding; Protein Conformation; Protein Domains; Pyridines; Thiazoles	2018
Heat shock protein 70 (Hsp70) mediates Zika virus entry, replication, and egress from host cells. Emerging microbes & infections, 2019, Volume: 8, Issue:1 Topics: Animals; Antibodies; Cell Line; Chlorocebus aethiops; Gene Expression Regulation; HEK293 Cells; HSP70 Heat-Shock Proteins; Humans; Pyridines; Thiazoles; Vero Cells; Virus Internalization; Virus Release; Virus Replication; Zika Virus; Zika Virus Infection	2019
Critical Role of Mortalin/GRP75 in Endothelial Cell Dysfunction Associated with Acute Lung Injury. Shock (Augusta, Ga.), 2020, Volume: 54, Issue:2 Topics: Acute Lung Injury; Animals; Endothelial Cells; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; HSP70 Heat-Shock Proteins; Humans; Inflammation; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Protein Binding; Pyridines; Signal Transduction; Thiazoles	2020
Mortalin contributes to colorectal cancer by promoting proliferation and epithelial-mesenchymal transition. IUBMB life, 2020, Volume: 72, Issue:4 Topics: beta Catenin; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Epithelial-Mesenchymal Transition; HSP70 Heat-Shock Proteins; Humans; Prognosis; Pyridines; Thiazoles; Wnt Signaling Pathway	2020
75-kDa glucose-regulated protein (GRP75) is a novel molecular signature for heat stress response in avian species. American journal of physiology. Cell physiology, 2020, 02-01, Volume: 318, Issue:2 Topics: Amino Acid Sequence; Animals; Cell Line; Cell Survival; Chickens; Chromatography, Liquid; Glucose; Heat-Shock Response; Hepatocytes; HSP70 Heat-Shock Proteins; Male; Membrane Proteins; Mitochondria; Myoblasts; Pyridines; Quail; Small Molecule Libraries; Tandem Mass Spectrometry; Thiazoles; Up-Regulation	2020
Analogs of the Heat Shock Protein 70 Inhibitor MKT-077 Suppress Medullary Thyroid Carcinoma Cells. International journal of molecular sciences, 2022, Jan-19, Volume: 23, Issue:3 Topics: Animals; Carcinoma, Neuroendocrine; Cell Line, Tumor; HSP70 Heat-Shock Proteins; Humans; Mice; Pyridines; Thiazoles; Thyroid Neoplasms	2022