Compounds > thiazoles
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thiazoles and mk0767

thiazoles has been researched along with mk0767 in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's12 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Berger, JP; Biswas, C; Chao, YS; Doebber, TW; Ippolito, MC; Kelly, LJ; Li, Y; Meurer, R; Moller, DE; Wang, PR; Wright, SD; Wu, MS; Zhou, G1
Biba, M; Chilenski, J; Karanam, BV; Reddy, VG; Vincent, S; Welch, CJ1
Creighton, M; Doss, GA; Franklin, RB; Karanam, BV; Kochansky, CJ; Reddy, VB; Vincent, SH1
Bakhtiar, R; Franklin, RB; Kochansky, C; Shen, Z; Vincent, SH1
Awano, K; Dean, D; Hop, CE; Karanam, BV; Komuro, M; Liu, DQ; Satoh, H; Vincent, SH; Wallace, M1
Doss, GA; Hop, CE; Karanam, BV; Liu, DQ; Sidler, RR; Vincent, SH1
Lo, MW; Song, H; Xu, X; Yan, K1
Lo, MW; Song, H; Yan, KX1
Awano, K; Bakhtiar, R; Colletti, A; Feeney, W; Franklin, RB; Hora, D; Iliff, S; Komuro, M; Shen, Z; Taga, F; Vincent, S1
Davies, MJ; De Smet, M; Decochez, K; Gottesdiener, KM; Johnson-Levonas, AO; Keymeulen, B; Matthijs, Z; Maynor, HO; Miller, JL; Riffel, KA; Rippley, RK; Song, H; Tanaka, W; Wagner, JA; Yan, KX; Zhu, H1
Dean, D; Franklin, RB; Jones, AN; Kochansky, CJ; Lasseter, K; Rippley, RK; Schwartz, J; Song, H; Vincent, SH; Wagner, J; Wallace, MA; Yan, KX1
Greenberg, HE; Herman, GA; Matthews, ND; Rippley, RK; Wagner, JA; Yan, KX1

Trials

3 trial(s) available for thiazoles and mk0767

ArticleYear
A dual PPAR alpha/gamma agonist increases adiponectin and improves plasma lipid profiles in healthy subjects.
    Drugs in R&D, 2006, Volume: 7, Issue:2

    Topics: Adiponectin; Adolescent; Adult; Area Under Curve; Blood Glucose; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Diarrhea; Dose-Response Relationship, Drug; Double-Blind Method; Fatigue; Fatty Acids, Nonesterified; Headache; Humans; Hypolipidemic Agents; Insulin; Lipids; Male; Middle Aged; PPAR alpha; PPAR gamma; Thiazoles; Triglycerides

2006
Absorption, metabolism, and excretion of [14C]MK-0767 (2-methoxy-5-(2,4-dioxo-5-thiazolidinyl)-N-[[4-(trifluoromethyl)phenyl] methyl]benzamide) in humans.
    Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:9

    Topics: Absorption; Administration, Oral; Adolescent; Adult; Biotransformation; Carbon Radioisotopes; Feces; Humans; Hypoglycemic Agents; Male; Middle Aged; Thiazoles

2006
Human pharmacokinetics and interconversion of enantiomers of MK-0767, a dual PPARalpha/gamma agonist.
    Journal of clinical pharmacology, 2007, Volume: 47, Issue:3

    Topics: Administration, Oral; Adolescent; Adult; Algorithms; Area Under Curve; Creatine Kinase; Female; Half-Life; Humans; Male; Middle Aged; Models, Biological; Molecular Structure; PPAR alpha; PPAR gamma; Racemases and Epimerases; Serum Albumin; Stereoisomerism; Tablets; Thiazoles

2007

Other Studies

9 other study(ies) available for thiazoles and mk0767

ArticleYear
MK-0767, a novel dual PPARalpha/gamma agonist, displays robust antihyperglycemic and hypolipidemic activities.
    Biochemical and biophysical research communications, 2004, May-28, Volume: 318, Issue:2

    Topics: Animals; Benzamides; Blood Glucose; Chlorocebus aethiops; Cholesterol; COS Cells; Cricetinae; Dogs; Dose-Response Relationship, Drug; Drug Synergism; Female; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Insulin; Male; Mesocricetus; Mice; Mice, Obese; Pioglitazone; Receptors, Cytoplasmic and Nuclear; Simvastatin; Thiazoles; Thiazolidinediones; Trans-Activators; Transcription Factors; Transcriptional Activation; Triglycerides

2004
Species differential stereoselective oxidation of a methylsulfide metabolite of MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl)phenyl]methyl]benzamide], a peroxisome proliferator-activated receptor dual agonist.
    Drug metabolism and disposition: the biological fate of chemicals, 2004, Volume: 32, Issue:10

    Topics: Animals; Cell Line; Dogs; Humans; Insecta; Macaca mulatta; Microsomes, Liver; Oxidation-Reduction; Peroxisome Proliferator-Activated Receptors; Rats; Species Specificity; Stereoisomerism; Sulfuric Acid Esters; Thiazoles

2004
Identification and metabolism of a novel dihydrohydroxy-S-glutathionyl conjugate of a peroxisome proliferator-activated receptor agonist, MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl) phenyl]methyl]benzamide], in r
    Drug metabolism and disposition: the biological fate of chemicals, 2004, Volume: 32, Issue:10

    Topics: Animals; Dogs; Glutathione; Humans; Intestine, Small; Macaca mulatta; Male; Microsomes, Liver; Peroxisome Proliferator-Activated Receptors; Rats; Rats, Sprague-Dawley; Thiazoles

2004
Simultaneous determination of MK-0767 and seven metabolites in rat urine using liquid chromatography/tandem mass spectrometry.
    Rapid communications in mass spectrometry : RCM, 2004, Volume: 18, Issue:18

    Topics: Administration, Oral; Algorithms; Animals; Chromatography, Liquid; Dose-Response Relationship, Drug; Male; Mass Spectrometry; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Sex Factors; Spectrometry, Mass, Electrospray Ionization; Thiazoles; Urinalysis

2004
In vitro metabolism of MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl) phenyl]methyl]benzamide], a peroxisome proliferator-activated receptor alpha/gamma agonist. I. Role of cytochrome P450, methyltransferases, flavi
    Drug metabolism and disposition: the biological fate of chemicals, 2004, Volume: 32, Issue:9

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzylamines; Carbon Radioisotopes; Cytosol; Dogs; Drug Evaluation, Preclinical; Esterases; Hepatocytes; Humans; Ketoconazole; Macaca mulatta; Methyltransferases; Microsomes, Liver; Mixed Function Oxygenases; NADP; PPAR alpha; PPAR gamma; Rats; S-Adenosylmethionine; Sulfhydryl Compounds; Sulfoxides; Temperature; Thiazoles; Thiazolidinediones

2004
In vitro metabolism of MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl)-phenyl] methyl]benzamide], a peroxisome proliferator-activated receptor alpha/gamma agonist. II. Identification of metabolites by liquid chromato
    Drug metabolism and disposition: the biological fate of chemicals, 2004, Volume: 32, Issue:9

    Topics: Animals; Carbon Radioisotopes; Chromatography, Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dogs; Drug Evaluation, Preclinical; Glucuronides; Haplorhini; Hepatocytes; Humans; Mass Spectrometry; Microsomes, Liver; NADP; PPAR alpha; PPAR gamma; Rats; S-Adenosylmethionine; Sulfhydryl Compounds; Thiazoles; Thiazolidinediones

2004
Quantitative determination of MK-0767, a dual alpha/gamma peroxisome proliferator-activated receptor (PPAR) agonist, in human plasma by liquid chromatography-tandem mass spectrometry.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2004, Oct-15, Volume: 810, Issue:1

    Topics: Calibration; Chromatography, High Pressure Liquid; Freezing; Indicators and Reagents; Mass Spectrometry; PPAR alpha; PPAR gamma; Quality Control; Reference Standards; Reproducibility of Results; Specimen Handling; Thiazoles

2004
Determination of MK-0767 enantiomers in human plasma by normal phase LC-MS/MS.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2004, Dec-25, Volume: 813, Issue:1-2

    Topics: Chromatography, Liquid; Humans; Mass Spectrometry; Reference Standards; Sensitivity and Specificity; Stereoisomerism; Thiazoles

2004
Enantiomer ratio of MK-0767 in humans and nonclinical species.
    Rapid communications in mass spectrometry : RCM, 2005, Volume: 19, Issue:9

    Topics: Animals; Dogs; Haplorhini; Humans; Mice; Molecular Structure; Rabbits; Rats; Species Specificity; Stereoisomerism; Thiazoles

2005