Compounds > thiazoles
Page last updated: 2024-08-21

thiazoles and midostaurin

thiazoles has been researched along with midostaurin in 18 studies

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (5.56)18.2507
2000's6 (33.33)29.6817
2010's11 (61.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cherington, V; Corbley, MJ; Lydon, NB; Roberts, TM; Traxler, PM1
Armstrong, SA; Beverloo, HB; de Lorenzo, P; den Boer, ML; Horstmann, M; Nollau, P; Pieters, R; Sallan, SE; Schneider, P; Stam, RW; Valsecchi, MG; van der Voort, E1
von Mehren, M1
Aichberger, KJ; Baumgartner, C; Fabbro, D; Gleixner, KV; Gruze, A; Lee, FY; Manley, PW; Mayerhofer, M; Pickl, WF; Samorapoompichit, P; Sillaber, C; Sonneck, K; Valent, P1
Bui, B; Italiano, A1
Tallman, M1
Baumgartner, C; Gleixner, KV; Gruze, A; Hadzijusufovic, E; Peter, B; Pickl, WF; Rebuzzi, L; Thaiwong, T; Valent, P; Willmann, M; Yuzbasiyan-Gurkan, V1
Ashman, LK; Griffith, R; Mashkani, B1
Gleixner, KV; Hadzijusufovic, E; Mirkina, I; Peter, B; Pickl, WF; Schuch, K; Thaiwong, T; Valent, P; Willmann, M; Yuzbasiyan-Gurkan, V1
Pardanani, A1
Akin, C; DeRemer, DL; Ustun, C1
Bennett, KL; Cerny-Reiterer, S; Gleixner, KV; Gotlib, J; Hadzijusufovic, E; Hörmann, G; Horny, HP; Mayerhofer, M; Meyer, RA; Mitterbauer-Hohendanner, G; Pickl, WF; Reiter, A; Rix, U; Superti-Furga, G; Valent, P1
Adamia, S; Barrett, R; Daley, JF; Fox, E; Frank, D; Griffin, JD; Nelson, E; Ray, A; Sattler, M; Weisberg, E; Zhang, C1
Bronson, R; Christie, AL; Daley, JF; Galinsky, I; Gray, N; Griffin, JD; Hur, W; Kung, AL; Liu, Q; Mitsiades, C; Nelson, E; Sanda, T; Sattler, M; Smith, R; Stone, R; Weisberg, E; Zhao, Z1
Lancet, JE1
Barra, FF; Costa, FF; de Melo Campos, P; Duarte, AS; Lorand-Metze, I; Machado-Neto, JA; Olalla Saad, ST; Rogers, HJ; Scopim-Ribeiro, R; Tabarroki, A; Tiu, RV; Traina, F; Vassalo, J; Visconte, V1
Bauer, K; Cerny-Reiterer, S; Hadzijusufovic, E; Hoermann, G; Pirker, A; Reifinger, M; Valent, P; Willmann, M1
Backman, JT; Filppula, AM; Mustonen, TM1

Reviews

4 review(s) available for thiazoles and midostaurin

ArticleYear
Beyond imatinib: second generation c-KIT inhibitors for the management of gastrointestinal stromal tumors.
    Clinical colorectal cancer, 2006, Volume: 6 Suppl 1

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Benzamides; Bevacizumab; Clinical Trials as Topic; Dasatinib; Drug Resistance, Neoplasm; Everolimus; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Immunosuppressive Agents; Indoles; Niacinamide; Oligonucleotides; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyrimidines; Pyrroles; Sirolimus; Staurosporine; Sunitinib; Thiazoles

2006
[Gastrointestinal stromal tumors: molecular aspects and therapeutic implications].
    Bulletin du cancer, 2008, Volume: 95, Issue:1

    Topics: Antineoplastic Agents; Benzamides; Benzenesulfonates; Disease Progression; Drug Resistance, Neoplasm; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Indoles; Mutation; Neoplasm Proteins; Niacinamide; Oligonucleotides; Phenylurea Compounds; Phthalazines; Piperazines; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyridines; Pyrimidines; Pyrroles; Receptor, Platelet-Derived Growth Factor alpha; Sorafenib; Staurosporine; Sunitinib; Thiazoles

2008
Tyrosine kinase inhibitors in the treatment of systemic mastocytosis.
    Leukemia research, 2011, Volume: 35, Issue:9

    Topics: Animals; Benzamides; Dasatinib; Humans; Imatinib Mesylate; Mastocytosis, Systemic; Mutation; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyrimidines; Staurosporine; Thiazoles

2011
New agents: great expectations not realized.
    Best practice & research. Clinical haematology, 2013, Volume: 26, Issue:3

    Topics: Aminoglycosides; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Arabinonucleosides; Benzothiazoles; Cytosine; Gemtuzumab; Humans; Hydroxamic Acids; Leukemia, Myeloid, Acute; Naphthyridines; Phenylurea Compounds; Prognosis; Randomized Controlled Trials as Topic; Recurrence; Remission Induction; Staurosporine; Survival Analysis; Thiazoles; Treatment Failure; Vorinostat

2013

Other Studies

14 other study(ies) available for thiazoles and midostaurin

ArticleYear
A strategy for screening anti-tumor drugs utilizing oncogenes encoded in retroviral vectors.
    International journal of cancer, 1996, Jun-11, Volume: 66, Issue:6

    Topics: 3T3 Cells; Alkaloids; Animals; Antigens, Polyomavirus Transforming; Benzamides; Cell Division; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Ethers, Cyclic; Genes, ras; Genes, src; Genetic Vectors; Hydroquinones; Mice; Okadaic Acid; Oncogenes; Phenols; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Retroviridae; Signal Transduction; Staurosporine; Styrenes; Sulfones; Thiazoles

1996
Targeting FLT3 in primary MLL-gene-rearranged infant acute lymphoblastic leukemia.
    Blood, 2005, Oct-01, Volume: 106, Issue:7

    Topics: Antineoplastic Agents; Apoptosis; Binding Sites; Cell Line, Tumor; DNA; DNA Mutational Analysis; DNA Primers; Dose-Response Relationship, Drug; Drug Resistance; Enzyme Inhibitors; Gene Duplication; Gene Rearrangement; Humans; Immunoprecipitation; In Situ Hybridization, Fluorescence; Infant; Infant, Newborn; Ligands; Mutation; Phosphorylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Reverse Transcriptase Polymerase Chain Reaction; RNA; Sequence Analysis, DNA; Staurosporine; Tetrazolium Salts; Thiazoles

2005
Synergistic growth-inhibitory effects of two tyrosine kinase inhibitors, dasatinib and PKC412, on neoplastic mast cells expressing the D816V-mutated oncogenic variant of KIT.
    Haematologica, 2007, Volume: 92, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Division; Cell Survival; Dasatinib; Drug Synergism; Humans; Mast Cells; Mastocytosis, Systemic; Mutation, Missense; Neoplasm Proteins; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyrimidines; Staurosporine; Thiazoles

2007
Existing and emerging therapeutic options for the treatment of acute myeloid leukemia.
    Clinical advances in hematology & oncology : H&O, 2008, Volume: 6, Issue:11

    Topics: Adenine; Adenine Nucleotides; Aminoglycosides; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Arabinonucleosides; Carbazoles; Clofarabine; Cytarabine; Dasatinib; Daunorubicin; fms-Like Tyrosine Kinase 3; Furans; Gemtuzumab; Humans; Leukemia, Myeloid, Acute; Naphthalimides; Organophosphonates; Prognosis; Protein Kinase Inhibitors; Pyrimidines; Sesquiterpenes; Staurosporine; Stem Cell Transplantation; Thiazoles; Tretinoin

2008
Growth-inhibitory effects of four tyrosine kinase inhibitors on neoplastic feline mast cells exhibiting a Kit exon 8 ITD mutation.
    Veterinary immunology and immunopathology, 2009, Dec-15, Volume: 132, Issue:2-4

    Topics: Animals; Apoptosis; Base Sequence; Benzamides; Cat Diseases; Cats; Cell Proliferation; Dasatinib; DNA Primers; Exons; Female; Humans; Imatinib Mesylate; In Vitro Techniques; Male; Mast Cells; Mastocytosis, Systemic; Molecular Sequence Data; Mutation; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyrimidines; Staurosporine; Tandem Repeat Sequences; Thiazoles

2009
Colony stimulating factor-1 receptor as a target for small molecule inhibitors.
    Bioorganic & medicinal chemistry, 2010, Mar-01, Volume: 18, Issue:5

    Topics: Benzamides; Binding Sites; Carbazoles; Computer Simulation; Dasatinib; Drug Design; Furans; Humans; Hydrogen Bonding; Imatinib Mesylate; Indoles; Piperazines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Receptor, Macrophage Colony-Stimulating Factor; Staurosporine; Sunitinib; Thiazoles

2010
H1-receptor antagonists terfenadine and loratadine inhibit spontaneous growth of neoplastic mast cells.
    Experimental hematology, 2010, Volume: 38, Issue:10

    Topics: Animals; Apoptosis; Blotting, Western; Caspase 3; Cats; Cell Line, Tumor; Cell Proliferation; Dasatinib; Dogs; Dose-Response Relationship, Drug; Drug Synergism; Flow Cytometry; Histamine H1 Antagonists, Non-Sedating; Humans; Inhibitory Concentration 50; Loratadine; Mastocytoma; Mastocytosis, Systemic; Proto-Oncogene Proteins c-kit; Pyrimidines; Staurosporine; Terfenadine; Thiazoles; Tumor Cells, Cultured

2010
Systemic mastocytosis in adults: 2011 update on diagnosis, risk stratification, and management.
    American journal of hematology, 2011, Volume: 86, Issue:4

    Topics: Adult; Antineoplastic Agents; Benzamides; Bone Marrow; Cladribine; Dasatinib; Disease-Free Survival; Humans; Hydroxyurea; Imatinib Mesylate; Interferon Type I; Mast Cells; Mastocytosis, Systemic; Piperazines; Point Mutation; Proto-Oncogene Proteins c-kit; Pyrimidines; Recombinant Proteins; Risk; Staurosporine; Thiazoles

2011
KIT-D816V-independent oncogenic signaling in neoplastic cells in systemic mastocytosis: role of Lyn and Btk activation and disruption by dasatinib and bosutinib.
    Blood, 2011, Aug-18, Volume: 118, Issue:7

    Topics: Agammaglobulinaemia Tyrosine Kinase; Aniline Compounds; Cell Line, Tumor; Dasatinib; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Mast Cells; Mastocytosis, Systemic; Mutation; Nitriles; Phosphorylation; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-kit; Pyrimidines; Quinolines; Signal Transduction; src-Family Kinases; Staurosporine; Thiazoles; Tumor Cells, Cultured

2011
Reversible resistance induced by FLT3 inhibition: a novel resistance mechanism in mutant FLT3-expressing cells.
    PloS one, 2011, Volume: 6, Issue:9

    Topics: Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Enzyme Stability; fms-Like Tyrosine Kinase 3; Gene Expression Regulation, Neoplastic; Half-Life; Humans; Leukemia, Myeloid, Acute; Mutation; Phosphorylation; Piperazines; Protein Kinase Inhibitors; RNA, Messenger; Signal Transduction; Staurosporine; Thiazoles; Tyrosine; Up-Regulation

2011
Using combination therapy to override stromal-mediated chemoresistance in mutant FLT3-positive AML: synergism between FLT3 inhibitors, dasatinib/multi-targeted inhibitors and JAK inhibitors.
    Leukemia, 2012, Volume: 26, Issue:10

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dasatinib; Drug Resistance, Neoplasm; fms-Like Tyrosine Kinase 3; Humans; Janus Kinases; Leukemia, Myeloid, Acute; Mice; Mutation; Protein Kinase Inhibitors; Pyrimidines; STAT5 Transcription Factor; Staurosporine; Stromal Cells; Thiazoles

2012
Familial systemic mastocytosis with germline KIT K509I mutation is sensitive to treatment with imatinib, dasatinib and PKC412.
    Leukemia research, 2014, Volume: 38, Issue:10

    Topics: Adult; Apoptosis; Base Sequence; Benzamides; Blotting, Western; Dasatinib; Female; Germ-Line Mutation; Humans; Imatinib Mesylate; Mastocytosis, Systemic; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyrimidines; Staurosporine; Thiazoles; Young Adult

2014
IL-4 downregulates expression of the target receptor CD30 in neoplastic canine mast cells.
    Veterinary and comparative oncology, 2017, Volume: 15, Issue:4

    Topics: Animals; Antineoplastic Agents; Apoptosis; Benzamides; Brentuximab Vedotin; Cell Line, Tumor; Cytokines; Dog Diseases; Dogs; Down-Regulation; Drug Synergism; Female; Immunoconjugates; Interleukin-4; Ki-1 Antigen; Male; Mastocytosis; Piperidines; Pyridines; Staurosporine; Thiazoles

2017
In Vitro Screening of Six Protein Kinase Inhibitors for Time-Dependent Inhibition of CYP2C8 and CYP3A4: Possible Implications with regard to Drug-Drug Interactions.
    Basic & clinical pharmacology & toxicology, 2018, Volume: 123, Issue:6

    Topics: Benzamides; Benzimidazoles; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C8 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Humans; Indoles; Inhibitory Concentration 50; Microsomes, Liver; Phthalazines; Piperidines; Pyridines; Pyridones; Pyrimidinones; Quinolones; Staurosporine; Thiazoles

2018