Page last updated: 2024-08-21

thiazoles and lubeluzole

thiazoles has been researched along with lubeluzole in 65 studies

Research

Studies (65)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	32 (49.23)	18.2507
2000's	24 (36.92)	29.6817
2010's	7 (10.77)	24.3611
2020's	2 (3.08)	2.80

Authors

Authors	Studies
De Keyser, J; Diener, HC; Hacke, W; Hantson, L; Hennerici, M; Rådberg, J	1
Arita, J; Eto, K; Hashimoto, K; Ni, C; Sugiyama, A; Xue, YX	1
Aronowski, J; Grotta, JC; Strong, R	2
Claes, C; Clincke, G; De Ryck, M; Duytschaever, H; Janssen, M; Keersmaekers, R; Van Reet, G	1
Lesage, AS; Leysen, JE; Peeters, L	1
Kue, I; Maiese, K; TenBroeke, M	1
Ashton, D; Clincke, G; Marrannes, R; Van Reempts, J; Willems, R; Wynants, J	1
Borgers, M; Haseldonckx, M; Van de Ven, M; Van Reempts, J; Wouters, L	1
Buchkremer-Ratzmann, I; Witte, OW	1
Dyker, AG; Lees, KR	1
de Pascual, R; Gandía, L; García, AG; Hernández-Guijo, JM	1
Crabbé, R; Gheuens, J; Hantson, L; Tritsmans, L; Van Rooy, P	1
Grotta, J	3
Clincke, G; de Ryck, M; Scheller, D; Tegtmeier, F	1
Clincke, G; De Ryck, M; Kolb, J; Scheller, DK; Szathmary, S; Tegtmeier, F; van Reempts, J	1
Gandía, L; García, AG; Lara, B; Martínez-Sierra, R; Torres, A	1
Culmsee, C; Junker, V; Krieglstein, J; Semkova, I; Wolz, P	1
August, M; Buchkremer-Ratzmann, I; Hagemann, G; Witte, OW	1
Lodder, J	1
Lees, KR	1
Clincke, G; De Prins, E; Marrannes, R	1
Cano-Abad, MF; Gandía, L; García, AG; Hernández-Guijo, JM; López, MG; Sánchez-García, P; Zapater, P	1
Crabbe, R; Hantson, L; Heykants, J; Van de Velde, V; Van Osselaer, N; Van Peer, A; Woestenborghs, R	1
Beard, DC; Billingsley, ML; Burkhart, KK; Lehman, RA	1
Grotta, J; Hickenbottom, SL	1
Demchuk, AM; Hantson, L; Jauss, M; Kasner, SE; Krieger, DW	1
Funato, H; Kohsaka, S; Mochizuki, H; Shimojo, M; Takasugi, K; Yamamoto, I	1
Kern, M; Kroppenstedt, SN; Schneider, GH; Stroop, R; Thomale, UW; Unterberg, AW	1
Hanke, W; Wiedemann, M	1
Bankhead, C	1
Maiese, K; Vincent, AM	2
De Ryck, M; Van der Linden, AM; Verhoye, M	1
De Prins, E; Marrannes, R	1
Cortens, M; Diener, HC; Ford, G; Grotta, J; Hacke, W; Kaste, M; Koudstaal, PJ; Wessel, T	1
Dippel, DW; Du Ry van Beest Holle, M; Koudstaal, PJ; van Kooten, F	1
Fisher, M; Schaebitz, W	1
Que, M; Witte, OW; Zilles, K	1
Gudelsky, GA; Vorhees, CV; Wallace, TL	1
Anthonsen, T; Berg, TC; Hoff, BH; Liu, HL	1
Koinig, H; Rueda, C; Vornik, V; Zornow, MH	1
Albrecht, J; Borkowska, HD; Hilgier, W; Oja, SS; Saransaari, P; Zielińska, M	1
Conti, M; Gandolfo, C; Sandercock, P	1
Berger, R; Garnier, Y; Jensen, A; Löbbert, T	1
Sareen, D	1
Diener, HC; Wessel, TC	1
Brantley, DR; Deyo, DJ; Disterhoft, JF; Mueller, RN; Zornow, MH	1
John, GW; Le Grand, B; Patoiseau, JF; Rieu, JP; Talmant, JM	1
Engel, DC; Maas, AI; Slemmer, JE; Vlug, AS; Weber, JT	1
Bruno, C; Carocci, A; Catalano, A; Cavalluzzi, MM; Corbo, F; Franchini, C; Lentini, G; Tortorella, V	1
Donnan, GA; Ly, JV; Zavala, JA	1
De Keyser, J; Koch, MW; Luijckx, GJ; Stewart, RE; Uyttenboogaart, M; Vroomen, PC	1
Bruno, C; Camerino, DC; Carbonara, R; Cavalluzzi, MM; Costanza, T; Desaphy, JF; Franchini, C; Lentini, G	1
Chakraborti, AK; Kommi, DN; Kumar, D; Seth, K	1
Bruno, C; Carocci, A; Carrieri, A; Catalano, A; Cavalluzzi, MM; Franchini, C; Lentini, G; Viale, M	1
Carbonara, R; Conte Camerino, D; Costanza, T; Desaphy, JF	1
Bruno, C; Carrieri, A; Cavalluzzi, MM; Franchini, C; Giannuzzi, G; Illario, M; Lentini, G; Lovece, A; Polimeno, L; Pracella, R; Rusciano, MR; Viale, M	1
Altamura, C; Desaphy, JF; Farinato, A	1
Cavalluzzi, MM; Convertino, M; Gailly, P; Gualdani, R; Lentini, G; Stary-Weinzinger, A; Tadini-Buoninsegni, F	1
Budriesi, R; Caputo, L; Cavalluzzi, MM; Corazza, I; De Salvia, MA; Franchini, C; Gualdani, R; Lentini, G; Micucci, M; Milani, G; Piarulli, M; Quintieri, L; Rosato, A; Viale, M	1
Bix, GJ; Fraser, JF; Gorman, A; Maniskas, ME; Roberts, JM	1

Reviews

8 review(s) available for thiazoles and lubeluzole

Article	Year
The rationale for new therapies in acute ischaemic stroke. Journal of clinical pharmacy and therapeutics, 1996, Volume: 21, Issue:6 Topics: Cerebrovascular Disorders; Disease Models, Animal; Humans; Neuroprotective Agents; Piperidines; Plasminogen Activators; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Thiazoles; Thrombolytic Therapy; Tissue Plasminogen Activator	1996
Neuroprotective therapy. Seminars in neurology, 1998, Volume: 18, Issue:4 Topics: Brain Ischemia; Calcium Channel Blockers; Clinical Trials as Topic; Cytoprotection; Excitatory Amino Acid Antagonists; Humans; Neuroprotective Agents; Piperidines; Thiazoles	1998
An overview of acute stroke therapy: past, present, and future. Archives of internal medicine, 2000, Nov-27, Volume: 160, Issue:21 Topics: Acute Disease; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Antibodies; Brain Ischemia; Calcium Channel Blockers; Cardiovascular Agents; Cell Adhesion Molecules; Clinical Trials as Topic; Cytidine Diphosphate Choline; Cytokines; Drug Therapy, Combination; Fibrinolytic Agents; Free Radical Scavengers; gamma-Aminobutyric Acid; Growth Substances; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; N-Methylaspartate; Neuroprotective Agents; Nootropic Agents; Piperidines; Stroke; Thiazoles; Thrombolytic Therapy	2000
Lubeluzole for acute ischaemic stroke. The Cochrane database of systematic reviews, 2002, Issue:1 Topics: Acute Disease; Brain Ischemia; Humans; Neuroprotective Agents; Piperidines; Thiazoles	2002
Neuroprotective agents in acute ischemic stroke. The Journal of the Association of Physicians of India, 2002, Volume: 50 Topics: Acute Disease; Adult; Aged; Animals; Antioxidants; Calcium Channel Blockers; Chlormethiazole; Clinical Trials as Topic; Clinical Trials, Phase III as Topic; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Forecasting; GABA Modulators; Guanidines; Humans; Imidazoles; Middle Aged; Naltrexone; Narcotic Antagonists; Neuroprotective Agents; Pipecolic Acids; Piperidines; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; Stroke; Thiazoles	2002
Nitrous oxide modulator: lubeluzole. Current medical research and opinion, 2002, Volume: 18 Suppl 2 Topics: Aged; Brain Ischemia; Humans; Neuroprotective Agents; Nitrous Oxide; Piperidines; Stroke; Thiazoles	2002
Neuroprotection and thrombolysis: combination therapy in acute ischaemic stroke. Expert opinion on pharmacotherapy, 2006, Volume: 7, Issue:12 Topics: Animals; Benzenesulfonates; Brain; Brain Ischemia; Drug Therapy, Combination; Fibrinolytic Agents; Free Radical Scavengers; GABA Agonists; Humans; Neuroprotective Agents; Nitrogen Oxides; Piperidines; Randomized Controlled Trials as Topic; Sodium Channel Blockers; Stroke; Thiazoles; Thrombolytic Therapy; Time Factors; Tissue Plasminogen Activator	2006
Effects of Benzothiazolamines on Voltage-Gated Sodium Channels. Handbook of experimental pharmacology, 2018, Volume: 246 Topics: Animals; Humans; Myotonia; Piperidines; Riluzole; Thiazoles; Voltage-Gated Sodium Channels	2018

Trials

10 trial(s) available for thiazoles and lubeluzole

Article	Year
Lubeluzole in acute ischemic stroke. A double-blind, placebo-controlled phase II trial. Lubeluzole International Study Group. Stroke, 1996, Volume: 27, Issue:1 Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Brain Ischemia; Cardiovascular Agents; Carotid Artery Diseases; Cerebrovascular Disorders; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Injections, Intravenous; Logistic Models; Male; Middle Aged; Multivariate Analysis; Piperidines; Placebos; Safety; Thiazoles	1996
The safety and tolerability of single intravenous doses of lubeluzole (Prosynap) in healthy volunteers. International journal of clinical pharmacology and therapeutics, 1997, Volume: 35, Issue:11 Topics: Adult; Cardiovascular Agents; Dose-Response Relationship, Drug; Electrocardiography; Hemodynamics; Humans; Injections, Intravenous; Male; Piperidines; Single-Blind Method; Thiazoles	1997
Lubeluzole treatment of acute ischemic stroke. The US and Canadian Lubeluzole Ischemic Stroke Study Group. Stroke, 1997, Volume: 28, Issue:12 Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Brain Ischemia; Cerebrovascular Disorders; Double-Blind Method; Female; Heart Diseases; Humans; Male; Middle Aged; Mortality; Neuroprotective Agents; Piperidines; Survival Analysis; Thiazoles; Treatment Outcome	1997
Pharmacokinetics of lubeluzole (Prosynap) after single intravenous doses in healthy subjects. International journal of clinical pharmacology and therapeutics, 1998, Volume: 36, Issue:9 Topics: Adult; Humans; Infusions, Intravenous; Male; Middle Aged; Neuroprotective Agents; Piperidines; Single-Blind Method; Thiazoles	1998
Early clinical and radiological predictors of fatal brain swelling in ischemic stroke. Stroke, 1999, Volume: 30, Issue:2 Topics: Acute Disease; Aged; Brain Edema; Brain Ischemia; Case-Control Studies; Cerebral Arteries; Female; Hospital Mortality; Humans; Male; Middle Aged; Neuroprotective Agents; Piperidines; Prognosis; Risk Factors; Severity of Illness Index; Thiazoles; Tomography, X-Ray Computed	1999
Lubeluzole in acute ischemic stroke treatment: A double-blind study with an 8-hour inclusion window comparing a 10-mg daily dose of lubeluzole with placebo. Stroke, 2000, Volume: 31, Issue:11 Topics: Acute Disease; Aged; Double-Blind Method; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Male; Neuroprotective Agents; Piperidines; Placebos; Severity of Illness Index; Stroke; Thiazoles; Treatment Outcome	2000
The validity and reliability of signs of early infarction on CT in acute ischaemic stroke. Neuroradiology, 2000, Volume: 42, Issue:9 Topics: Adult; Aged; Aged, 80 and over; Cerebral Infarction; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Neuroprotective Agents; Observer Variation; Piperidines; Predictive Value of Tests; Randomized Controlled Trials as Topic; Reproducibility of Results; Thiazoles; Thrombolytic Therapy; Time Factors; Tissue Plasminogen Activator; Tomography, X-Ray Computed	2000
Combination therapy stroke trial. rt-PA +/- lubeluzole. Annals of the New York Academy of Sciences, 2001, Volume: 939 Topics: Drug Therapy, Combination; Feasibility Studies; Humans; Neuroprotective Agents; Piperidines; Stroke; Thiazoles	2001
Combination Therapy Stroke Trial: recombinant tissue-type plasminogen activator with/without lubeluzole. Cerebrovascular diseases (Basel, Switzerland), 2001, Volume: 12, Issue:3 Topics: Activities of Daily Living; Aged; Cerebral Hemorrhage; Double-Blind Method; Feasibility Studies; Female; Glasgow Coma Scale; Humans; Male; Neuroprotective Agents; Piperidines; Plasminogen Activators; Prospective Studies; Recombinant Proteins; Stroke; Thiazoles; Tissue Plasminogen Activator	2001
Moderate hyperglycaemia is associated with favourable outcome in acute lacunar stroke. Brain : a journal of neurology, 2007, Volume: 130, Issue:Pt 6 Topics: Acute Disease; Aged; Aged, 80 and over; Blood Glucose; Brain Infarction; Female; Humans; Hyperglycemia; Male; Middle Aged; Neuroprotective Agents; Piperidines; Prognosis; Severity of Illness Index; Stroke; Thiazoles; Treatment Outcome	2007

Other Studies

47 other study(ies) available for thiazoles and lubeluzole

Article	Year
Effects of the antihypoxic and neuroprotective drug, lubeluzole, on repolarization phase of canine heart assessed by monophasic action potential recording. Toxicology and applied pharmacology, 1996, Volume: 139, Issue:1 Topics: Action Potentials; Animals; Blood Pressure; Cardiac Catheterization; Cardiovascular Agents; Disease Models, Animal; Dogs; Electrocardiography; Heart; Heart Rate; Injections, Intravenous; Microelectrodes; Myocardium; Neuroprotective Agents; Piperidines; Rats; Thiazoles	1996
Combined neuroprotection and reperfusion therapy for stroke. Effect of lubeluzole and diaspirin cross-linked hemoglobin in experimental focal ischemia. Stroke, 1996, Volume: 27, Issue:9 Topics: Animals; Aspirin; Cardiovascular Agents; Cerebral Infarction; Cerebrovascular Disorders; Drug Therapy, Combination; Hemodilution; Hemoglobins; Male; Neuroprotective Agents; Piperidines; Rats; Rats, Inbred Strains; Reperfusion; Thiazoles	1996
Treatment of experimental focal ischemia in rats with lubeluzole. Neuropharmacology, 1996, Volume: 35, Issue:6 Topics: Animals; Brain Ischemia; Disease Models, Animal; Neuroprotective Agents; Piperidines; Rats; Thiazoles	1996
Lubeluzole protects sensorimotor function and reduces infarct size in a photochemical stroke model in rats. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 279, Issue:2 Topics: Animals; Brain; Cerebral Cortex; Cerebral Infarction; Dizocilpine Maleate; Dose-Response Relationship, Drug; Male; Neuroprotective Agents; Nimodipine; Nitric Oxide Synthase; Photochemistry; Piperidines; Rats; Rats, Wistar; Stereoisomerism; Thiazoles	1996
Lubeluzole, a novel long-term neuroprotectant, inhibits the glutamate-activated nitric oxide synthase pathway. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 279, Issue:2 Topics: Animals; Arginine; Cells, Cultured; Cyclic GMP; Glutamic Acid; Guanylate Cyclase; Hippocampus; Interferon-gamma; Lipopolysaccharides; Neuroprotective Agents; Nitric Oxide Synthase; Piperidines; Rats; Stereoisomerism; Thiazoles	1996
Neuroprotection of lubeluzole is mediated through the signal transduction pathways of nitric oxide. Journal of neurochemistry, 1997, Volume: 68, Issue:2 Topics: Animals; Cell Death; Ischemic Preconditioning; Neurons; Neuroprotective Agents; Nitric Oxide; Piperidines; Rats; Rats, Sprague-Dawley; Signal Transduction; Thiazoles	1997
Altered Na(+)-channel function as an in vitro model of the ischemic penumbra: action of lubeluzole and other neuroprotective drugs. Brain research, 1997, Jan-16, Volume: 745, Issue:1-2 Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Cerebral Infarction; Cerebrovascular Circulation; Extracellular Space; Guinea Pigs; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Microelectrodes; Neuroprotective Agents; Piperidines; Pyramidal Cells; Sodium Channels; Thiazoles; Veratridine	1997
Protection with lubeluzole against delayed ischemic brain damage in rats. A quantitative histopathologic study. Stroke, 1997, Volume: 28, Issue:2 Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Carotid Stenosis; Cell Death; Drug Evaluation, Preclinical; Hippocampus; Ligation; Male; Neurons; Neuroprotective Agents; Piperidines; Rats; Rats, Wistar; Shock; Thiazoles; Time Factors	1997
Pharmacological reduction of electrophysiological diaschisis after photothrombotic ischemia in rat neocortex. European journal of pharmacology, 1997, Feb-12, Volume: 320, Issue:2-3 Topics: Animals; Cerebral Cortex; Dermatitis, Phototoxic; Disease Models, Animal; Dizocilpine Maleate; Electrophysiology; Evoked Potentials; Excitatory Amino Acid Antagonists; Intracranial Embolism and Thrombosis; Ischemic Attack, Transient; Male; Neuroprotective Agents; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Thiazoles	1997
Differential effects of the neuroprotectant lubeluzole on bovine and mouse chromaffin cell calcium channel subtypes. British journal of pharmacology, 1997, Volume: 122, Issue:2 Topics: Animals; Barium; Calcium Channel Blockers; Cattle; Chromaffin Cells; Mice; Neuroprotective Agents; Patch-Clamp Techniques; Piperidines; Stereoisomerism; Thiazoles	1997
Extracellular changes of taurine in the peri-infarct zone: effect of lubeluzole. Acta neurochirurgica. Supplement, 1997, Volume: 70 Topics: Animals; Cerebral Infarction; Male; Neuroprotective Agents; Piperidines; Rats; Rats, Wistar; Stereoisomerism; Taurine; Thiazoles	1997
Lubeluzole blocks increases in extracellular glutamate and taurine in the peri-infarct zone in rats. European journal of pharmacology, 1997, Nov-12, Volume: 338, Issue:3 Topics: Animals; Blood Pressure; Cerebral Infarction; Cortical Spreading Depression; Glutamic Acid; Glutamine; Heart Rate; Male; Neocortex; Neuroprotective Agents; Piperidines; Rats; Rats, Wistar; Taurine; Thiazoles	1997
Q-type Ca2+ channels are located closer to secretory sites than L-type channels: functional evidence in chromaffin cells. Pflugers Archiv : European journal of physiology, 1998, Volume: 435, Issue:4 Topics: Animals; Calcium Channel Blockers; Calcium Channels; Catecholamines; Cattle; Chromaffin Cells; Dihydropyridines; In Vitro Techniques; Neurosecretory Systems; omega-Agatoxin IVA; omega-Conotoxin GVIA; Peptides; Piperidines; Potassium; Spider Venoms; Thiazoles	1998
Lubeluzole protects hippocampal neurons from excitotoxicity in vitro and reduces brain damage caused by ischemia. European journal of pharmacology, 1998, Jan-26, Volume: 342, Issue:2-3 Topics: Animals; Animals, Newborn; Astrocytes; Brain Ischemia; Cells, Cultured; Excitatory Amino Acids; Glutamic Acid; Hippocampus; Male; Mice; Neurons; Neuroprotective Agents; Piperidines; Rats; Rats, Inbred F344; Stereoisomerism; Thiazoles	1998
Epileptiform discharges to extracellular stimuli in rat neocortical slices after photothrombotic infarction. Journal of the neurological sciences, 1998, Apr-01, Volume: 156, Issue:2 Topics: Animals; Cerebral Infarction; Dizocilpine Maleate; Electric Stimulation; Electrophysiology; Epilepsy; In Vitro Techniques; Intracranial Embolism and Thrombosis; Light; Male; Neocortex; Neuroprotective Agents; Piperidines; Rats; Rats, Wistar; Reaction Time; Thiazoles	1998
Lubeluzole treatment of acute ischemic stroke. Stroke, 1998, Volume: 29, Issue:5 Topics: Acute Disease; Brain Ischemia; Cardiovascular Agents; Cerebrovascular Disorders; Humans; Piperidines; Thiazoles	1998
Does neuroprotection improve stroke outcome? Lancet (London, England), 1998, May-16, Volume: 351, Issue:9114 Topics: Cerebrovascular Disorders; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Neuroprotective Agents; Piperidines; Randomized Controlled Trials as Topic; Research Design; Thiazoles; Thrombolytic Therapy; Time Factors; Treatment Outcome	1998
Influence of lubeluzole on voltage-sensitive Ca++ channels in isolated rat neurons. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 286, Issue:1 Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dose-Response Relationship, Drug; Ganglia, Spinal; Male; Neuroprotective Agents; Piperidines; Rats; Rats, Wistar; Stereoisomerism; Thiazoles	1998
Effects of the neuroprotectant lubeluzole on the cytotoxic actions of veratridine, barium, ouabain and 6-hydroxydopamine in chromaffin cells. British journal of pharmacology, 1998, Volume: 124, Issue:6 Topics: Adrenal Glands; Animals; Barium; Calcium; Cattle; Chromaffin Cells; Cytosol; Neuroprotective Agents; Ouabain; Oxidopamine; Penfluridol; Piperidines; Sodium; Thiazoles; Veratridine	1998
Alterations in tau phosphorylation in rat and human neocortical brain slices following hypoxia and glucose deprivation. Experimental neurology, 1998, Volume: 154, Issue:2 Topics: Animals; Brain Ischemia; Cell Hypoxia; Enzyme Inhibitors; Glucose; Humans; Hypoglycemia; Hypoxia, Brain; Male; Neocortex; Neuroprotective Agents; Okadaic Acid; Organ Culture Techniques; Phosphorylation; Piperidines; Precipitin Tests; Rats; Rats, Sprague-Dawley; tau Proteins; Temporal Lobe; Thiazoles	1998
Neuroprotective action of a novel compound--M50463--in primary cultured neurons. Brain research, 1999, Jan-02, Volume: 815, Issue:1 Topics: Acetylcysteine; Animals; Antihypertensive Agents; Batrachotoxins; Binding Sites; Binding, Competitive; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cell Death; Cells, Cultured; Culture Media, Serum-Free; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Indoles; Neurons; Neuroprotective Agents; Neurotoxins; Nicardipine; Nitroprusside; Piperidines; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Sodium Channels; Thiazoles; Veratrine; Vitamin E	1999
Lubeluzole following traumatic brain injury in the rat. Journal of neurotrauma, 1999, Volume: 16, Issue:7 Topics: Animals; Blood Gas Analysis; Blood Pressure; Body Water; Brain Edema; Brain Injuries; Enzyme Inhibitors; Intracranial Pressure; Magnetic Resonance Imaging; Male; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Piperidines; Rats; Rats, Sprague-Dawley; Thiazoles; Time Factors	1999
Lubeluzole shows neuroprotective effects in an "in-vitro"-model for neuronal lesions in the chicken retina. Brain research, 1999, Sep-18, Volume: 842, Issue:1 Topics: Animals; Chickens; Electric Stimulation; Electrophysiology; In Vitro Techniques; Neurons; Neuroprotective Agents; Piperidines; Retina; Stereoisomerism; Thiazoles	1999
Lubeluzole. JK 8792, R 87926, Prosynap. Drugs in R&D, 1999, Volume: 1, Issue:1 Topics: Acute Disease; Brain Ischemia; Drugs, Investigational; Humans; Neuroprotective Agents; Piperidines; Stroke; Thiazoles	1999
What's new with neuroprotective agents in stroke? Drugs in R&D, 1999, Volume: 1, Issue:1 Topics: Animals; Chlormethiazole; Cytidine Diphosphate Choline; Drugs, Investigational; Humans; Neuroprotective Agents; Nootropic Agents; Piperidines; Stroke; Thiazoles	1999
Membrane asymmetry and DNA degradation: functionally distinct determinants of neuronal programmed cell death. Journal of neuroscience research, 2000, Feb-15, Volume: 59, Issue:4 Topics: Animals; Animals, Newborn; Annexin A5; Apoptosis; Biomarkers; Cell Membrane; Cell Nucleus; DNA; Enzyme Inhibitors; Free Radical Scavengers; Hippocampus; Neurons; Neuroprotective Agents; Nitric Oxide; Phosphatidylserines; Piperidines; Rats; Rats, Sprague-Dawley; Thiazoles; Triazenes	2000
Diffusion-weighted MRI of infarct growth in a rat photochemical stroke model: effect of lubeluzole. Neuropharmacology, 2000, Feb-14, Volume: 39, Issue:4 Topics: Animals; Cerebral Infarction; Diffusion; Magnetic Resonance Imaging; Male; Motor Cortex; Neocortex; Neuroprotective Agents; Photochemistry; Piperidines; Rats; Rats, Wistar; Somatosensory Cortex; Thiazoles	2000
Critical temporal modulation of neuronal programmed cell injury. Cellular and molecular neurobiology, 2000, Volume: 20, Issue:3 Topics: Animals; Annexin A5; Apoptosis; Biomarkers; Cell Membrane; Cell Survival; DNA Fragmentation; Hippocampus; Molsidomine; Neurons; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Phosphatidylserines; Piperidines; Rats; Rats, Sprague-Dawley; Thiazoles; Vasodilator Agents	2000
Site of action of lubeluzole on voltage-sensitive Ca(2+) channels in isolated dorsal root ganglion cells of the rat: influence of pH. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:2 Topics: Animals; Benzothiazoles; Calcium Channel Blockers; Calcium Channels; Electric Stimulation; Ganglia, Spinal; Hydrogen-Ion Concentration; Kinetics; Male; Neurons, Afferent; Neuroprotective Agents; Patch-Clamp Techniques; Piperidines; Rats; Rats, Wistar; Thiazoles	2000
Transient up-regulation of gamma-aminobutyric acid(A) receptor binding by lubeluzole after neocortical specify lesion in rats. Neuroscience letters, 2000, Dec-22, Volume: 296, Issue:2-3 Topics: Animals; Brain Ischemia; Male; Muscimol; Neocortex; Neuroprotective Agents; Photochemistry; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, AMPA; Receptors, GABA-A; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Rose Bengal; Thiazoles; Tritium; Up-Regulation	2000
Effects of lubeluzole on the methamphetamine-induced increase in extracellular glutamate and the long-term depletion of striatal dopamine. Synapse (New York, N.Y.), 2001, Volume: 40, Issue:2 Topics: Animals; Body Temperature; Dopamine; Drug Interactions; Extracellular Space; Glutamic Acid; Male; Methamphetamine; Neostriatum; Neurons; Neuroprotective Agents; Piperidines; Rats; Rats, Sprague-Dawley; Sodium Channels; Thiazoles; Veratridine	2001
Synthesis of the antistroke drug lubeluzole and its enantiomer. Lipase-catalyzed resolution of chiral building block. Chirality, 2001, Volume: 13, Issue:3 Topics: Cardiovascular Agents; Catalysis; Lipase; Piperidines; Propanols; Stereoisomerism; Substrate Specificity; Thiazoles	2001
Lubeluzole inhibits accumulation of extracellular glutamate in the hippocampus during transient global cerebral ischemia. Brain research, 2001, Apr-20, Volume: 898, Issue:2 Topics: Action Potentials; Animals; Body Temperature; Brain Ischemia; Cardiovascular Physiological Phenomena; Extracellular Space; Glutamic Acid; Hippocampus; Microdialysis; Nerve Degeneration; Neurons; Neuroprotective Agents; Piperidines; Rabbits; Reperfusion Injury; Respiratory Physiological Phenomena; Thiazoles	2001
Lubeluzole attenuates K(+)-evoked extracellular accumulation of taurine in the striatum of healthy rats and rats with hepatic failure. Brain research, 2001, Jun-15, Volume: 904, Issue:1 Topics: Animals; Extracellular Space; Glutamic Acid; Hepatic Encephalopathy; Male; Microdialysis; Neostriatum; Neurons; Neuroprotective Agents; Osmotic Pressure; Piperidines; Potassium Chloride; Rats; Rats, Wistar; Taurine; Thiazoles; Thioacetamide	2001
Lubeluzole pretreatment does not provide neuroprotection against transient global cerebral ischemia in fetal sheep near term. Pediatric research, 2002, Volume: 51, Issue:4 Topics: Acid-Base Equilibrium; Animals; Blood Gas Analysis; Brain; Brain Ischemia; Cerebrovascular Circulation; Female; Fetal Diseases; Gestational Age; Humans; Neuroprotective Agents; Piperidines; Pregnancy; Sheep; Thiazoles	2002
Lubeluzole and conditioned learning after cerebral ischemia. Experimental brain research, 2003, Volume: 152, Issue:3 Topics: Animals; Brain Ischemia; Conditioning, Psychological; Learning; Male; Piperidines; Rabbits; Thiazoles	2003
Study of the interaction of lubeluzole with cardiac sodium channels. Journal of cardiovascular pharmacology, 2003, Volume: 42, Issue:5 Topics: Animals; Dose-Response Relationship, Drug; Guinea Pigs; Male; Membrane Potentials; Myocardium; Piperidines; Sodium Channels; Thiazoles	2003
Combined effects of mechanical and ischemic injury to cortical cells: secondary ischemia increases damage and decreases effects of neuroprotective agents. Neuropharmacology, 2005, Volume: 49, Issue:7 Topics: Animals; Brain Ischemia; Cell Count; Cell Survival; Cells, Cultured; Cerebral Cortex; Enzyme Inhibitors; Immunohistochemistry; Indazoles; Mice; Mitogen-Activated Protein Kinase 1; Neurons; Neuroprotective Agents; Nitric Oxide Synthase Type I; Physical Stimulation; Piperidines; Stress, Mechanical; Superoxide Dismutase; Thiazoles	2005
Facile, alternative route to lubeluzole, its enantiomer, and the racemate. Chirality, 2006, May-05, Volume: 18, Issue:4 Topics: Cardiovascular Agents; Molecular Structure; Piperidines; Stereoisomerism; Thiazoles	2006
Molecular dissection of lubeluzole use-dependent block of voltage-gated sodium channels discloses new therapeutic potentials. Molecular pharmacology, 2013, Volume: 83, Issue:2 Topics: Anesthetics, Local; Binding Sites; Cell Line; HEK293 Cells; Humans; Membrane Potentials; Membrane Proteins; Mutation; NAV1.4 Voltage-Gated Sodium Channel; Neuroprotective Agents; Piperidines; Protein Binding; Protein Interaction Domains and Motifs; Protein Isoforms; Riluzole; Sodium Channel Blockers; Thiazoles	2013
Protecting group-free concise synthesis of (RS)/(S)-lubeluzole. Organic letters, 2013, Mar-15, Volume: 15, Issue:6 Topics: Hydrogen Bonding; Molecular Structure; Piperidines; Solvents; Stereoisomerism; Thiazoles; Water	2013
A convenient synthesis of lubeluzole and its enantiomer: evaluation as chemosensitizing agents on human ovarian adenocarcinoma and lung carcinoma cells. Bioorganic & medicinal chemistry letters, 2013, Sep-01, Volume: 23, Issue:17 Topics: Adenocarcinoma; Antineoplastic Agents; Cell Line, Tumor; Doxorubicin; Drug Synergism; Female; Humans; Lung Neoplasms; Ovarian Neoplasms; Paclitaxel; Piperidines; Stereoisomerism; Thiazoles	2013
Preclinical evaluation of marketed sodium channel blockers in a rat model of myotonia discloses promising antimyotonic drugs. Experimental neurology, 2014, Volume: 255 Topics: Animals; Carbamazepine; Disease Models, Animal; Flecainide; HEK293 Cells; Humans; Mexiletine; Muscle, Skeletal; Myotonia Congenita; Orphenadrine; Piperidines; Propafenone; Rats; Rats, Wistar; Riluzole; Sodium Channel Blockers; Thiazoles	2014
The chemosensitizing agent lubeluzole binds calmodulin and inhibits Ca(2+)/calmodulin-dependent kinase II. European journal of medicinal chemistry, 2016, Jun-30, Volume: 116 Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calmodulin; Cattle; Humans; Molecular Docking Simulation; Piperidines; Protein Conformation; Protein Kinase Inhibitors; Thiazoles	2016
Molecular Insights into hERG Potassium Channel Blockade by Lubeluzole. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Volume: 45, Issue:6 Topics: Animals; CHO Cells; Cricetulus; Ether-A-Go-Go Potassium Channels; HEK293 Cells; Humans; Molecular Docking Simulation; Neuroprotective Agents; Patch-Clamp Techniques; Piperidines; Point Mutation; Protein Binding; Protein Conformation, alpha-Helical; Thiazoles	2018
Lubeluzole: from anti-ischemic drug to preclinical antidiarrheal studies. Pharmacological reports : PR, 2021, Volume: 73, Issue:1 Topics: Animals; Anti-Bacterial Agents; Antidiarrheals; Bacteria; Colon; Diarrhea; Dose-Response Relationship, Drug; Gram-Negative Bacterial Infections; Gram-Positive Bacterial Infections; Guinea Pigs; Ileum; Loperamide; Male; Microbial Sensitivity Tests; Muscle Contraction; Neuroprotective Agents; Piperidines; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Thiazoles	2021
Intra-arterial combination therapy for experimental acute ischemic stroke. Clinical and translational science, 2022, Volume: 15, Issue:1 Topics: Animals; Calcium Channel Blockers; Combined Modality Therapy; Infusions, Intra-Arterial; Ischemic Stroke; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Piperidines; Thiazoles; Treatment Outcome; Verapamil	2022