Page last updated: 2024-08-21

thiazoles and lff571

thiazoles has been researched along with lff571 in 12 studies

Research

Studies (12)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	12 (100.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Citron, DM; Goldstein, EJ; Merriam, CV; Tyrrell, KL	1
Amaral, A; Brewer, JT; Bushell, SM; Deng, G; Dewhurst, JM; Ding, J; Dzink-Fox, J; Gamber, G; Jain, A; LaMarche, MJ; Lee, K; Lee, L; Leeds, JA; Lister, T; McKenney, D; Mullin, S; Osborne, C; Palestrant, D; Patane, MA; Rann, EM; Sachdeva, M; Shao, J; Tiamfook, S; Trzasko, A; Whitehead, L; Yan, W; Yifru, A; Yu, D; Zhu, Q	1
Lamarche, MJ; Leeds, JA; McKenney, D; Praestgaard, J; Trzasko, A	1
Dzink-Fox, J; Lamarche, MJ; Leeds, JA; Mullin, S; Sachdeva, M	1
Grunenberg, N; Leeds, JA; Pertel, P; Praestgaard, J; Ting, LS; Yang, JC	1
Bauer, MP; Debast, SB; Kuijper, EJ; Sanders, IM; Wilcox, MH	1
Barnes, SW; Leeds, JA; Mullin, S; Ruzin, A; Sachdeva, M	1
Leeds, JA; Sachdeva, M	1
Bhansali, SG; Dabovic, K; Leeds, JA; Mullane, K; Pertel, P; Praestgaard, J; Ting, LS	1
Blais, J; Bressler, A; Buitrago, M; Dabovic, K; Lee, C; Leeds, JA; Mullane, K; Pertel, P; Praestgaard, J; Weiss, K	1
Leeds, JA	1
Alam, MJ; Bassères, E; Dotson, KM; Endres, BT; Garey, KW	1

Reviews

2 review(s) available for thiazoles and lff571

Article	Year
Antibacterials Developed to Target a Single Organism: Mechanisms and Frequencies of Reduced Susceptibility to the Novel Anti-Clostridium difficile Compounds Fidaxomicin and LFF571. Cold Spring Harbor perspectives in medicine, 2016, Feb-01, Volume: 6, Issue:2 Topics: Aminoglycosides; Anti-Bacterial Agents; Clinical Trials, Phase III as Topic; Clostridioides difficile; Clostridium Infections; Drug Resistance, Bacterial; Fidaxomicin; Genotype; Humans; Microbial Sensitivity Tests; Mutation; Thiazoles	2016
Novel antibiotics in development to treat Clostridium difficile infection. Current opinion in gastroenterology, 2017, Volume: 33, Issue:1 Topics: Anti-Bacterial Agents; Benzimidazoles; Benzopyrans; Clinical Trials as Topic; Clostridium Infections; Depsipeptides; Humans; Lipopeptides; Oxazolidinones; Peptides, Cyclic; Pyridines; Thiazoles; Thiophenes	2017

Article

Year

Antibacterials Developed to Target a Single Organism: Mechanisms and Frequencies of Reduced Susceptibility to the Novel Anti-Clostridium difficile Compounds Fidaxomicin and LFF571.

Cold Spring Harbor perspectives in medicine, 2016, Feb-01, Volume: 6, Issue:2

Topics: Aminoglycosides; Anti-Bacterial Agents; Clinical Trials, Phase III as Topic; Clostridioides difficile; Clostridium Infections; Drug Resistance, Bacterial; Fidaxomicin; Genotype; Humans; Microbial Sensitivity Tests; Mutation; Thiazoles

2016

Novel antibiotics in development to treat Clostridium difficile infection.

Current opinion in gastroenterology, 2017, Volume: 33, Issue:1

Topics: Anti-Bacterial Agents; Benzimidazoles; Benzopyrans; Clinical Trials as Topic; Clostridium Infections; Depsipeptides; Humans; Lipopeptides; Oxazolidinones; Peptides, Cyclic; Pyridines; Thiazoles; Thiophenes

2017

Trials

3 trial(s) available for thiazoles and lff571

Article	Year
A first-in-human, randomized, double-blind, placebo-controlled, single- and multiple-ascending oral dose study to assess the safety and tolerability of LFF571 in healthy volunteers. Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:11 Topics: Administration, Oral; Adolescent; Adult; Anti-Bacterial Agents; Area Under Curve; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Dosage Calculations; Drug Monitoring; Feces; Female; Humans; Male; Middle Aged; Placebos; Thiazoles	2012
Pharmacokinetics of LFF571 and vancomycin in patients with moderate Clostridium difficile infections. Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:3 Topics: Anti-Bacterial Agents; Clostridioides difficile; Clostridium Infections; Feces; Female; Humans; Male; Middle Aged; Thiazoles; Vancomycin	2015
Multicenter, randomized clinical trial to compare the safety and efficacy of LFF571 and vancomycin for Clostridium difficile infections. Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Clostridioides difficile; Clostridium Infections; Female; Humans; Male; Middle Aged; Thiazoles; Vancomycin	2015

Other Studies

7 other study(ies) available for thiazoles and lff571

Article	Year
Comparative in vitro activities of LFF571 against Clostridium difficile and 630 other intestinal strains of aerobic and anaerobic bacteria. Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:5 Topics: Aminoglycosides; Anti-Bacterial Agents; Bacteria, Aerobic; Bacteria, Anaerobic; Clostridioides difficile; Enterocolitis, Pseudomembranous; Fidaxomicin; Humans; Intestines; Microbial Sensitivity Tests; Microbial Viability; Peptide Elongation Factor Tu; Protein Biosynthesis; Species Specificity; Thiazoles	2012
Discovery of LFF571: an investigational agent for Clostridium difficile infection. Journal of medicinal chemistry, 2012, Mar-08, Volume: 55, Issue:5 Topics: Animals; Anti-Bacterial Agents; Clostridioides difficile; Cricetinae; Crystallography, X-Ray; Enterococcus; Enterocolitis, Pseudomembranous; Escherichia coli Proteins; Female; Male; Mesocricetus; Mice; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Peptide Elongation Factor Tu; Rats; Rats, Sprague-Dawley; Solubility; Staphylococcus aureus; Streptococcus pyogenes; Structure-Activity Relationship; Thiazoles; Water	2012
Efficacy of LFF571 in a hamster model of Clostridium difficile infection. Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:8 Topics: Animals; Anti-Bacterial Agents; Bacterial Proteins; Bacterial Toxins; Clostridioides difficile; Cricetinae; Enterocolitis, Pseudomembranous; Enterotoxins; Male; Mesocricetus; Recurrence; Thiazoles; Vancomycin	2012
Mechanism of action of and mechanism of reduced susceptibility to the novel anti-Clostridium difficile compound LFF571. Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:8 Topics: Anti-Bacterial Agents; Binding Sites; Clostridioides difficile; Drug Resistance, Bacterial; Enterocolitis, Pseudomembranous; Humans; Microbial Sensitivity Tests; Peptide Chain Elongation, Translational; Peptide Elongation Factor Tu; Protein Structure, Tertiary; Thiazoles	2012
Antimicrobial activity of LFF571 and three treatment agents against Clostridium difficile isolates collected for a pan-European survey in 2008: clinical and therapeutic implications. The Journal of antimicrobial chemotherapy, 2013, Volume: 68, Issue:6 Topics: Aminoglycosides; Anti-Bacterial Agents; Clostridioides difficile; Clostridium Infections; Cross Infection; Enterocolitis, Pseudomembranous; Europe; Fidaxomicin; Humans; Metronidazole; Microbial Sensitivity Tests; Multilocus Sequence Typing; Polymerase Chain Reaction; Ribotyping; Thiazoles; Treatment Outcome; Vancomycin	2013
In vitro selection, via serial passage, of Clostridium difficile mutants with reduced susceptibility to fidaxomicin or vancomycin. The Journal of antimicrobial chemotherapy, 2014, Volume: 69, Issue:1 Topics: Aminoglycosides; Anti-Bacterial Agents; Cell Wall; Clostridioides difficile; DNA Mutational Analysis; DNA-Directed RNA Polymerases; DNA, Bacterial; Drug Resistance, Bacterial; Fidaxomicin; Genome, Bacterial; Humans; Microbial Sensitivity Tests; Mutation; Selection, Genetic; Sequence Analysis, DNA; Serial Passage; Thiazoles; Vancomycin	2014
Subinhibitory concentrations of LFF571 reduce toxin production by Clostridium difficile. Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:2 Topics: Aminoglycosides; Clostridioides difficile; Fidaxomicin; Metronidazole; Microbial Sensitivity Tests; Thiazoles; Vancomycin	2015