thiazoles has been researched along with leukotriene b4 in 49 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (10.20) | 18.7374 |
| 1990's | 28 (57.14) | 18.2507 |
| 2000's | 12 (24.49) | 29.6817 |
| 2010's | 4 (8.16) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bird, TG; Bruneau, P; Crawley, GC; Dowell, RI; Edwards, PN; Foster, SJ; Giroaeau, JM; McMillan, RM; Walker, ER; Waterson, D | 1 |
| Greco, MN; Hageman, WE; Persico, FJ; Powell, ET; Tighe, JJ | 1 |
| Abe, S; Katayama, K; Katayama, S; Sakuma, Y; Tsunoda, H; Yamatsu, I | 2 |
| Asano, M; Hamada, K; Inamura, N; Isono, T; Kohsaka, M; Nagayoshi, A; Nakahara, K; Notsu, Y; Oku, T; Ono, T | 1 |
| Bruneau, P; Crawley, GC; Edwards, MP; Foster, SJ; Girodeau, JM; Kingston, JF; McMillan, RM | 1 |
| Griswold, DE; Hillegass, LM; Webb, EF | 1 |
| Howard, MO; Newton, JF; Qualls, CW; Schwartz, LW; Ventre, JR; Yodis, LA | 1 |
| Abe, S; Katayama, K; Katayama, S; Sakuma, Y; Tanaka, S; Tsukidate, K; Tsunoda, H; Yamatsu, I | 1 |
| Belliotti, TR; Boctor, AM; Connor, DT; Flynn, DL; Kostlan, CR; Nies, DE; Ortwine, DF; Schrier, DJ; Sircar, JC | 1 |
| Bonne, C; Meynier, F; Muller, A | 1 |
| Foster, SJ; Girodeau, JM; McMillan, RM | 1 |
| Anderson, DC; Hughes, H; Mitchell, JR; Shappell, SB; Smith, CW; Taylor, AA | 1 |
| Caon, AC; Gilbert, C; Liao, N; McColl, SR; Naccache, PH; Therrien, S | 1 |
| Bender, PE; Griswold, DE; Hanna, N; Hillegass, L; Hoffstein, S; Marshall, PJ; Webb, EF | 1 |
| DiMartino, MJ; Gleason, JG; Godfrey, R; Griswold, DE; Hanna, N; Marshall, PJ; Newton, J; Poste, G; Sarau, HM; Webb, EF | 1 |
| Deacon, RW; Farley, C; Handley, DA; Saunders, RN | 1 |
| Bureau, M; Joseph, D; Vargaftig, BB | 1 |
| Obata, Y; Oda, M; Yamamoto, N; Yokota, K | 2 |
| Akutsu, I; Fukuda, T; Makino, S; Motojima, S; Numao, T; Toda, M | 1 |
| Barnes, PJ; Giembycz, MA; Lindsay, MA; Perkins, RS | 1 |
| Breton, J; Griswold, DE; Marshall, PJ; Torphy, TJ; Webb, EF; White, JR | 1 |
| Leduc, D; Pretolani, M; Vargaftig, BB; Zuany-Amorim, C | 1 |
| Au, BT; Hellewell, PG; Rossi, AG; Teixeira, MM; Williams, TJ | 1 |
| Hsyu, PH; Koets, MD; Luderer, JR | 1 |
| Hibi, S; Inoue, T; Kawahara, T; Kobayashi, N; Murakami, M; Numata, H; Okamoto, Y; Oketani, K; Shinoda, M; Tagami, K | 1 |
| Anglin, CP; Djuric, SW; Docter, SH; Fretland, DJ; Kachur, JF; Keith, RH; Penning, TD; Spangler, D; Tsai, BS; Yu, SS | 1 |
| Anglin, CP; Djuric, SW; Fretland, DJ; Penning, TD; Widomski, DL; Yu, S | 1 |
| Bögel, R; Engelhardt, G; Schnitzler, C; Utzmann, R | 1 |
| Carlson, RP; Glaser, K; Grimes, D; Gunawan, I; Hartman, DA; Howell, R; Kanzelberger, M; Malamas, MS; Nelson, JA; Shah, U | 1 |
| Hilger, RA; Köller, M; König, W | 1 |
| Bae, SJ; Hakugawa, J; Katayama, I; Tanaka, Y; Vinuesa, MA | 1 |
| Hirasawa, N; Kushihara, M; Ohuchi, K; Takahagi, H; Takasaki, W; Takayanagi, M; Yamashita, M | 1 |
| Arimura, A; Hori, Y; Inagaki, M; Jyoyama, H; Kakudo, S; Kato, M; Kawai, S; Kobayashi, M; Koizumi, K; Matsumoto, S; Ohno, K; Ono, T; Suzuki, R; Tsuri, T; Yamada, K; Yasui, K | 1 |
| Arakida, Y; Morio, H; Ohga, K; Okada, Y; Suwa, K; Yamada, T; Yokota, M | 1 |
| Kersten, S; Wahli, W | 1 |
| Chang, DM; Hsieh, TC; Hsu, CT; Kuo, SY; Young, TH | 1 |
| Hla, T; Inoue , K; Kawahito, Y; Kohno, M; Sano, H; Tsubouchi, Y | 1 |
| Harada, K; Inoue, T; Nagakura, N; Oketani, K | 1 |
| Inoue, T; Murakami, M; Oketani, K | 1 |
| Cerdá-Nicolás, M; Giner, RM; Giner-Larza, EM; Máñez, S; Prieto, JM; Recio, MC; Ríos, JL | 1 |
| Baba, T; Inagaki, M; Iwatani, K; Jyoyama, H; Kobayashi, M; Matsumoto, S; Ohkawa, T; Ono, T; Touchi, A; Tsuri, T; Yamada, K | 1 |
| Inagaki, M | 1 |
| Bélanger, C; Borgeat, P; Elimam, H; Lefebvre, J; Marleau, S | 1 |
| Cheon, HG; Cho, YS; Kang, NS; Kim, CH; Surh, JH; Yoo, SE | 1 |
| Budsberg, SC; Goodman, LA; Reynolds, LR; Torres, BT | 1 |
| Kim, KA; Kim, SH; Lee, YA; Min, A; Nam, YH; Shin, MH; Song, KJ | 1 |
| Barchuk, W; Barnathan, ES; Bertelsen, K; Fourie, A; Fuhr, R; Jiang, JZ; Lambert, J; Liu, X; Silkoff, PE; Thurmond, R | 1 |
2 review(s) available for thiazoles and leukotriene b4
| Article | Year |
|---|---|
Peroxisome proliferator activated receptor agonists.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Butyrates; Drug Design; Epoprostenol; Humans; Leukotriene B4; Mice; Mice, Knockout; Receptors, Cytoplasmic and Nuclear; Thiazoles; Transcription Factors | 2000 |
[Studies on the new antiarthritic drug candidate S-2474].
Topics: Animals; Antirheumatic Agents; Cyclic S-Oxides; Cyclooxygenase 2; Depression, Chemical; Dinoprostone; Drug Design; Humans; Interleukin-1; Isoenzymes; Leukotriene B4; Lipoxygenase Inhibitors; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Rats; Structure-Activity Relationship; Thiazoles | 2003 |
3 trial(s) available for thiazoles and leukotriene b4
| Article | Year |
|---|---|
Pharmacokinetics and cyclooxygenase inhibition of itazigrel in normal volunteers after single oral doses.
Topics: Administration, Oral; Adolescent; Adult; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Leukotriene B4; Male; Middle Aged; Single-Blind Method; Thiazoles; Thromboxane B2 | 1994 |
Endoscopic comparison of the gastroduodenal safety and the effects on arachidonic acid products between meloxicam and piroxicam in the treatment of osteoarthritis.
Topics: Adult; Aged; Arachidonic Acid; Cyclooxygenase Inhibitors; Digestive System; Dinoprostone; Double-Blind Method; Endoscopy, Digestive System; Female; Gastric Juice; Humans; Leukotriene B4; Male; Meloxicam; Middle Aged; Osteoarthritis, Knee; Pain; Pain Measurement; Piroxicam; Safety; Thiazines; Thiazoles; Thromboxane B2 | 2001 |
Effects of JNJ-40929837, a leukotriene A4 hydrolase inhibitor, in a bronchial allergen challenge model of asthma.
Topics: Acetates; Adult; Anti-Asthmatic Agents; Asthma; Bronchial Provocation Tests; Cross-Over Studies; Cyclopropanes; Double-Blind Method; Epoxide Hydrolases; Female; Forced Expiratory Volume; Humans; Leukotriene B4; Male; Quinolines; Sputum; Sulfides; Thiazoles; Treatment Outcome; Tropanes; Young Adult | 2014 |
44 other study(ies) available for thiazoles and leukotriene b4
| Article | Year |
|---|---|
Methoxytetrahydropyrans. A new series of selective and orally potent 5-lipoxygenase inhibitors.
Topics: Administration, Oral; Animals; Calcimycin; Drug Interactions; Eicosanoids; Humans; Leukotriene B4; Lipoxygenase Inhibitors; Macrophages; Mice; Naphthalenes; Peritoneal Cavity; Pyrans; Quinolones; Rats; Structure-Activity Relationship; Thiazoles | 1992 |
Benzothiazole hydroxy ureas as inhibitors of 5-lipoxygenase: use of the hydroxyurea moiety as a replacement for hydroxamic acid.
Topics: Animals; Benzothiazoles; Calcimycin; Dogs; Humans; Hydroxamic Acids; Hydroxyurea; Leukocytes; Leukotriene B4; Lipoxygenase Inhibitors; Methemoglobin; Mice; Molecular Structure; Peritonitis; SRS-A; Structure-Activity Relationship; Thiazoles | 1992 |
Effects of the new 5-lipoxygenase inhibitor E6080 on leukotriene release in vitro.
Topics: Animals; Arachidonate 5-Lipoxygenase; Basophils; Benzoquinones; Dose-Response Relationship, Drug; Guinea Pigs; Histamine Release; Humans; Hypersensitivity; In Vitro Techniques; Leukotriene B4; Leukotrienes; Lipoxygenase Inhibitors; Lung; Male; Neutrophils; SRS-A; Thiazoles | 1992 |
A 5-lipoxygenase inhibitor, FR110302, suppresses airway hyperresponsiveness and lung eosinophilia induced by Sephadex particles in rats.
Topics: Acetylcholine; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Chromones; Dextrans; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Indomethacin; Leukotriene B4; Lipoxygenase Inhibitors; Male; Microspheres; Naphthols; Platelet Activating Factor; Prednisolone; Pulmonary Eosinophilia; Pyridines; Quinolines; Rats; Rats, Inbred Strains; SRS-A; Thiazoles | 1992 |
(Methoxyalkyl)thiazoles: a new series of potent, selective, and orally active 5-lipoxygenase inhibitors displaying high enantioselectivity.
Topics: Administration, Oral; Animals; Chemical Phenomena; Chemistry; Enzyme Inhibitors; Guinea Pigs; Humans; Leukotriene B4; Lipoxygenase Inhibitors; Mice; Naphthalenes; Rats; Structure-Activity Relationship; Thiazoles; Thromboxane B2 | 1991 |
Determination of plasma leukotrienes in antigen-induced bronchoconstrictive guinea pigs.
Topics: Administration, Inhalation; Anaphylaxis; Animals; Antigens; Benzoquinones; Bronchoconstriction; Chromatography, High Pressure Liquid; Guinea Pigs; Injections, Intravenous; Leukotriene B4; Lipoxygenase Inhibitors; Male; Pyrazoles; Rabbits; Radioimmunoassay; SRS-A; Thiazoles | 1991 |
Induction of plasma exudation and inflammatory cell infiltration by leukotriene C4 and leukotriene B4 in mouse peritonitis.
Topics: Animals; Ascites; Capillary Permeability; Chemotaxis, Leukocyte; Colchicine; Drug Interactions; Imidazoles; Inflammation; Injections, Intraperitoneal; Leukotriene B4; Male; Mice; Mice, Inbred BALB C; Neutrophils; Peritonitis; Pyrazoles; SRS-A; Thiazoles | 1991 |
Comparative biochemical and morphometric changes associated with induction of the hepatic mixed function oxidase system in the rat.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Hypertrophy; Imidazoles; Leukotriene B4; Liver; Male; Microscopy, Electron; Mixed Function Oxygenases; Organ Size; Organelles; Phenobarbital; Rats; Rats, Inbred Strains; Thiazoles | 1991 |
Effect of a novel 5-lipoxygenase inhibitor, E6080 on bronchospasm, airway cellular infiltration and leukotriene production in guinea pigs.
Topics: Acetophenones; Animals; Autacoids; Benzoquinones; Bronchial Spasm; Bronchoalveolar Lavage Fluid; Eosinophils; Guinea Pigs; Leukotriene B4; Leukotrienes; Lipoxygenase Inhibitors; Male; Neutrophils; SRS-A; Tetrazoles; Thiazoles | 1991 |
Styrylpyrazoles, styrylisoxazoles, and styrylisothiazoles. Novel 5-lipoxygenase and cyclooxygenase inhibitors.
Topics: Animals; Chemical Phenomena; Chemistry; Cyclooxygenase Inhibitors; Isoxazoles; Leukotriene B4; Lipoxygenase Inhibitors; Male; Pyrazoles; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Thiazoles | 1991 |
PAF-induced conjunctivitis in the rabbit is mediated by peptido-leukotrienes.
Topics: Animals; Azepines; Conjunctiva; Conjunctivitis; Cyclooxygenase Inhibitors; Dicarboxylic Acids; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Indomethacin; Leukotriene B4; Leukotrienes; Lipoxygenase Inhibitors; Male; Platelet Activating Factor; Rabbits; Second Messenger Systems; Tetrazoles; Thiazoles; Thienopyridines; Triazoles | 1990 |
Selective chiral inhibitors of 5-lipoxygenase with anti-inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Eicosanoids; Humans; In Vitro Techniques; Indans; Inflammation; Leukotriene B4; Lipoxygenase Inhibitors; Rabbits; Rats; Stereoisomerism; Thiazoles | 1990 |
Comparison of antioxidant and nonantioxidant lipoxygenase inhibitors on neutrophil function. Implications for pathogenesis of myocardial reperfusion injury.
Topics: Antigens, Differentiation; Antioxidants; Cell Aggregation; Cell Movement; Humans; Hydroxyquinolines; Imidazoles; Leukotriene B4; Lipoxygenase Inhibitors; Macrophage-1 Antigen; Masoprocol; Myocardial Reperfusion Injury; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Quinolines; Receptors, Leukocyte-Adhesion; Thiazoles | 1990 |
Chemoattractant-induced cytoplasmic pH changes and cytoskeletal reorganization in human neutrophils. Relationship to the stimulated calcium transients and oxidative burst.
Topics: Actins; Binding, Competitive; Calcimycin; Calcium; Chemotactic Factors; Cytoplasm; Egtazic Acid; Humans; Leukotriene B4; Macromolecular Substances; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Onium Compounds; Oxygen Consumption; Pyrimidinones; Superoxides; Thiazoles | 1989 |
Inhibition of inflammatory cell infiltration by bicyclic imidazoles, SK&F 86002 and SK&F 104493.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemotaxis, Leukocyte; Cyclophosphamide; Dinoprostone; Ear Diseases; Edema; Eicosanoids; Imidazoles; Inflammation; Leukotriene B4; Male; Mice; Mice, Inbred BALB C; Neutrophils; Peritonitis; Pyridines; Thiazoles | 1989 |
SK&F 86002: a structurally novel anti-inflammatory agent that inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid.
Topics: Animals; Anti-Inflammatory Agents; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Humans; Imidazoles; Inflammation; Leukocytes; Leukotriene B4; Lipoxygenase Inhibitors; Mice; Pyrazoles; Rats; SRS-A; Thiazoles | 1987 |
Evidence for distinct systemic extravasation effects of platelet activating factor, leukotrienes B4, C4, D4 and histamine in the guinea pig.
Topics: Animals; Chromones; Diphenhydramine; Dose-Response Relationship, Drug; Guinea Pigs; Hematocrit; Hemorrhage; Histamine; Injections, Intravenous; Leukotriene B4; Male; Phospholipid Ethers; Plasma; Platelet Activating Factor; SRS-A; Thiazoles; Time Factors | 1986 |
Desensitization and antagonism of rat polymorphonuclear leukocytes stimulated with PAF acether.
Topics: Animals; Cells, Cultured; Cytochalasin B; Diterpenes; Exocytosis; Ginkgolides; Glucuronidase; Lactones; Leukotriene B4; Male; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Plant Extracts; Platelet Activating Factor; Pyridines; Rats; Rats, Inbred Strains; Thiazoles | 1987 |
Inhibitory effect of KBT-3022, a new anti-platelet agent, on infiltration of polymorphonuclear leukocytes induced by leukotriene B4 or formyl-methionyl-leucyl-phenylalanine in mice.
Topics: Animals; Dexamethasone; Dose-Response Relationship, Drug; Indomethacin; Leukocytes; Leukotriene B4; Mice; Mice, Inbred Strains; N-Formylmethionine Leucyl-Phenylalanine; Platelet Aggregation Inhibitors; Pyrroles; Thiazoles | 1995 |
Inhibition of leukotriene C4 and B4 release by human eosinophils with the new 5-lipoxygenase inhibitor 6-hydroxy-2(4-sulfamoylbenzylamino)-4,5,7-trimethylbenzothiazo le hydrochloride.
Topics: Asthma; Calcimycin; Dose-Response Relationship, Drug; Eosinophils; Humans; In Vitro Techniques; Ionophores; Leukotriene B4; Leukotriene C4; Lipoxygenase Inhibitors; Platelet Activating Factor; Thiazoles | 1995 |
Early signalling events implicated in leukotriene B4-induced activation of the NADPH oxidase in eosinophils: role of Ca2+, protein kinase C and phospholipases C and D.
Topics: Animals; Calcium; Chelating Agents; Diacylglycerol Kinase; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Eosinophils; Guinea Pigs; Humans; Hydrogen Peroxide; Indoles; Kinetics; Leukotriene B4; NADH, NADPH Oxidoreductases; NADPH Oxidases; Phorbol 12,13-Dibutyrate; Phospholipase D; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Pyrimidinones; Serum Albumin; Signal Transduction; Thiazoles; Type C Phospholipases | 1995 |
Effect of selective phosphodiesterase type IV inhibitor, rolipram, on fluid and cellular phases of inflammatory response.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Calcimycin; Cells, Cultured; Colforsin; Cyclic Nucleotide Phosphodiesterases, Type 4; Ear, External; Eicosanoids; Histamine Release; Humans; Imidazoles; Inflammation; Leukotriene B4; Male; Mast Cells; Mice; Mice, Inbred BALB C; Monocytes; Nadolol; Naproxen; Neutrophils; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Pyrazoles; Pyrrolidinones; Receptors, Adrenergic, beta; Rolipram; SRS-A; Thiazoles | 1993 |
Characterization and pharmacological modulation of antigen-induced peritonitis in actively sensitized mice.
Topics: Animals; Benzeneacetamides; Cetirizine; Cycloheximide; Dexamethasone; Eosinophils; Histamine Release; Hydroxamic Acids; Indomethacin; Kinetics; Leukocyte Count; Leukotriene B4; Leukotriene C4; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred BALB C; Ovalbumin; Peritoneal Cavity; Peritonitis; Platelet Activating Factor; T-Lymphocytes; Tacrolimus; Terfenadine; Thiazoles; Zymosan | 1993 |
Characterization of eosinophil homotypic aggregation.
Topics: Animals; Calcium; CD18 Antigens; Cell Aggregation; Drug Synergism; Eosinophils; Guinea Pigs; Leukotriene B4; Magnesium; Microscopy; Platelet Activating Factor; Pyrimidinones; Stimulation, Chemical; Superoxides; Thiazoles | 1995 |
Novel dual inhibitors of 5-lipoxygenase and thromboxane A2 synthetase: synthesis and structure-activity relationships of 3-pyridylmethyl-substituted 2-amino-6-hydroxybenzothiazole derivatives.
Topics: Animals; Blood Platelets; Cells, Cultured; Colitis; Dinoprostone; Disease Models, Animal; Humans; Leukotriene B4; Lipoxygenase Inhibitors; Male; Peritoneal Cavity; Rats; Rats, Inbred F344; Sheep; Structure-Activity Relationship; Thiazoles; Thromboxane B2; Thromboxane-A Synthase | 1994 |
The design and synthesis of second generation leukotriene B4 (LTB4) receptor antagonists related to SC-41930.
Topics: Animals; Benzopyrans; Binding Sites; Cell Degranulation; Chemotaxis, Leukocyte; Colitis; Dermatitis; Disease Models, Animal; Drug Design; Guinea Pigs; In Vitro Techniques; Leukotriene B4; Mice; Receptors, Leukotriene B4; Thiazoles | 1993 |
Leukotriene B4-induced granulocyte trafficking in guinea pig dermis. Effect of second-generation leukotriene B4 receptor antagonists, SC-50605 and SC-51146.
Topics: Administration, Oral; Animals; Benzamides; Benzopyrans; Chemotaxis, Leukocyte; Granulocytes; Guinea Pigs; Injections, Intradermal; Leukotriene B4; Male; Peroxidase; Receptors, Immunologic; Receptors, Leukotriene B4; Skin; Thiazoles | 1993 |
Meloxicam: influence on arachidonic acid metabolism. Part II. In vivo findings.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Brain; Convulsants; Cyclooxygenase Inhibitors; Dinoprostone; Female; Gastric Juice; Inflammation; Isoenzymes; Kidney; Leukotriene B4; Male; Meloxicam; Mice; Pentylenetetrazole; Pleurisy; Rats; Stomach; Thiazines; Thiazoles | 1996 |
Azole phenoxy hydroxyureas as selective and orally active inhibitors of 5-lipoxygenase.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Bronchoconstriction; Guinea Pigs; Humans; Hydroxyurea; Leukotriene B4; Lipoxygenase Inhibitors; Macrophages; Mice; Molecular Structure; Monocytes; Oxazoles; Rats; Structure-Activity Relationship; Thiazoles | 1996 |
Inhibitory effects of the new anti-platelet agent KBT-3022 and its metabolite on rabbit neutrophil function in vitro.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Binding Sites; Calcium; Cell Adhesion; Cilostazol; Complement C3-C5 Convertases; Complement C5a; Cyclooxygenase Inhibitors; Indomethacin; Leukotriene B4; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Aggregation Inhibitors; Pyrroles; Rabbits; Structure-Activity Relationship; Superoxides; Tetradecanoylphorbol Acetate; Tetrazoles; Thiazoles; Ticlopidine | 1996 |
Inhibition of leukotriene formation and IL-8 release by the paf-receptor antagonist SM-12502.
Topics: Aluminum; Basophils; Calcimycin; Calcium; Depression, Chemical; Gene Expression Regulation; GTP-Binding Proteins; Humans; Interleukin-8; Ionophores; Leukocytes, Mononuclear; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Sodium Fluoride; Thiazoles; Thiazolidines | 1996 |
[The inhibitory effect of LTB4 antagonist on eosinophil infiltration in cutaneous and gut late phase response in BALB/C mice sensitized with ovalubumin (OVA)].
Topics: Animals; Cell Movement; Dermatitis, Atopic; Eosinophils; Female; Immunization; Immunosuppressive Agents; Intestines; Leukotriene B4; Mice; Mice, Inbred BALB C; Ovalbumin; Phenylpropionates; Platelet Activating Factor; Skin; Thiazoles | 1997 |
Inhibition by troglitazone of the antigen-induced production of leukotrienes in immunoglobulin E-sensitized RBL-2H3 cells.
Topics: Animals; Antigens; Arachidonic Acid; Calcimycin; Cell Degranulation; Cell Line; Chromans; Culture Media, Conditioned; Hydroxyurea; Hypoglycemic Agents; Immunoglobulin E; Leukotriene B4; Leukotriene C4; Leukotriene E4; Leukotrienes; Lipoxygenase Inhibitors; Male; Mast Cells; Neutrophils; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Novel antiarthritic agents with 1,2-isothiazolidine-1,1-dioxide (gamma-sultam) skeleton: cytokine suppressive dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Experimental; Blood Platelets; Cyclic S-Oxides; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Edema; Female; Gastric Mucosa; Humans; Interleukin-1; Isoenzymes; Leukotriene B4; Lipoxygenase Inhibitors; Male; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Lew; Structure-Activity Relationship; Synovial Membrane; Thiazoles | 2000 |
Effect of combined leukotriene D(4) and thromboxane A(2) receptor antagonist on mediator-controlled resistance in guinea pigs.
Topics: Administration, Oral; Airway Resistance; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Antigens; Asthma; Benzoquinones; Chromones; Dose-Response Relationship, Drug; Guinea Pigs; Heptanoic Acids; Indomethacin; Leukotriene Antagonists; Leukotriene B4; Leukotriene C4; Leukotriene E4; Lipid Metabolism; Lung; Male; Membrane Proteins; Ovalbumin; Receptors, Leukotriene; Receptors, Thromboxane; Tetrazoles; Thiazoles; Thromboxane B2; Time Factors | 2000 |
Feedback control of the arachidonate cascade in rheumatoid synoviocytes by 15-deoxy-Delta(12,14)-prostaglandin J2.
Topics: Arachidonic Acid; Arthritis, Rheumatoid; Chromans; Cyclooxygenase 2; Cysteine; Dinoprostone; Feedback; Humans; Isoenzymes; Leukotriene Antagonists; Leukotriene B4; Leukotrienes; Membrane Proteins; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Receptors, Cytoplasmic and Nuclear; Synovial Membrane; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2001 |
In vitro effects of E3040, a dual inhibitor of 5-lipoxygenase and thromboxane A(2) synthetase, on eicosanoid production.
Topics: Animals; Arachidonate 5-Lipoxygenase; Benzothiazoles; Dinoprostone; Dose-Response Relationship, Drug; Eicosanoids; Humans; Hydroxyurea; Indomethacin; Leukocytes; Leukotriene B4; Lipoxygenase Inhibitors; Male; Mesalamine; Methacrylates; Neutrophils; Peritoneal Cavity; Prostaglandin-Endoperoxide Synthases; Pyridines; Rats; Rats, Inbred F344; Sheep; Sulfasalazine; Thiazoles; Thromboxane B2; Thromboxane-A Synthase | 2001 |
Effect of E3040, an inhibitor of 5-lipoxygenase and thromboxane synthase, on rat bowel damage induced by lipopolysaccharide.
Topics: Animals; Benzothiazoles; Dinoprostone; Dose-Response Relationship, Drug; Eicosanoids; Gastrointestinal Agents; Injections, Intravenous; Intestinal Mucosa; Intestine, Large; Leukotriene B4; Lipopolysaccharides; Lipoxygenase Inhibitors; Male; Prednisolone; Pyridines; Rats; Rats, Inbred F344; Sulfasalazine; Thiazoles; Thromboxane B2; Thromboxane-A Synthase; Time Factors | 2001 |
Oleanonic acid, a 3-oxotriterpene from Pistacia, inhibits leukotriene synthesis and has anti-inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Cyclooxygenase Inhibitors; Drug Screening Assays, Antitumor; Ear, External; Edema; Female; Foot; Humans; Hypersensitivity, Delayed; In Vitro Techniques; Inflammation; Leukotriene B4; Leukotrienes; Mice; Neutrophils; Oleanolic Acid; Oxidation-Reduction; Peroxidase; Pistacia; Rats; Structure-Activity Relationship; Tetrazolium Salts; Thiazoles; Triterpenes | 2001 |
Synthesis and activities of oxidative metabolites of the anti-arthritic drug candidate S-2474.
Topics: Animals; Anti-Inflammatory Agents; Benzofurans; Cyclic S-Oxides; Dinoprostone; Edema; Humans; Interleukin-1; Leukotriene B4; Lipoxygenase Inhibitors; Microsomes, Liver; Rats; Thiazoles | 2003 |
Involvement of endogenous leukotriene B4 and platelet-activating factor in polymorphonuclear leucocyte recruitment to dermal inflammatory sites in rats.
Topics: Animals; Benzopyrans; Carboxylic Acids; Dermatitis; Dihydropyridines; Imidazoles; Leukotriene B4; Male; Neutrophil Infiltration; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pneumonia; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Leukotriene B4; Skin; Thiazoles | 2008 |
Identification of 4-[4-(4-fluoro-phenyl)-thiazol-2-ylamino]-2,6-dimethyl-phenol (KR-33749) as an inhibitor of 5-lipoxygenase with potent antiinflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Cell Line, Tumor; Dermatitis, Atopic; Dinitrochlorobenzene; Dose-Response Relationship, Drug; Edema; Isoenzymes; Leukotriene B4; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred BALB C; Osmolar Concentration; Rats; Recombinant Proteins; Skin; Skin Diseases; Thiazoles; Time Factors; Xylenes | 2010 |
Effects of firocoxib, meloxicam, and tepoxalin administration on eicosanoid production in target tissues of healthy cats.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cats; Cross-Over Studies; Cyclooxygenase Inhibitors; Dinoprostone; Duodenum; Eicosanoids; Gastric Mucosa; Intestinal Mucosa; Kinetics; Leukotriene B4; Male; Meloxicam; Orchiectomy; Pyrazoles; Reference Values; Sulfones; Thiazines; Thiazoles | 2010 |
Leukotriene B(4) receptors BLT1 and BLT2 are involved in interleukin-8 production in human neutrophils induced by Trichomonas vaginalis-derived secretory products.
Topics: Benzoquinones; Endopeptidase K; Fatty Alcohols; Glycols; Hot Temperature; Humans; Interleukin-8; Leukotriene Antagonists; Leukotriene B4; Lipase; Lipoxygenase Inhibitors; Neutrophil Activation; Neutrophils; Piperazines; Receptors, Leukotriene B4; Tetrazoles; Thiazoles; Trichomonas Infections; Trichomonas vaginalis | 2012 |