thiazoles has been researched along with leucine in 117 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (10.26) | 18.7374 |
| 1990's | 7 (5.98) | 18.2507 |
| 2000's | 30 (25.64) | 29.6817 |
| 2010's | 66 (56.41) | 24.3611 |
| 2020's | 2 (1.71) | 2.80 |
| Authors | Studies |
|---|---|
| Fustochenko, BP; Ostrovskií, IuM | 1 |
| Deutsch, HF; Fett, JW | 1 |
| Gautheron, PD; Laszek, MA; Sina, JF; Ward, GJ | 1 |
| Alonso, C; Castanys, S; Craciunescu, DG; Gamarro, F; Lopez, MC; Osuna, A; Ruiz-Perez, LM | 1 |
| Komai, T; Shindo, H | 1 |
| Coleman, WG; Williams, LS | 1 |
| Amaral, L; Pai, SH; Werthamer, S; Zak, FG | 1 |
| Fujita, T; Okano, K; Yoshikawa, M | 1 |
| Iwashima, A; Kawasaki, T; Nakamura, M; Nose, Y | 1 |
| Daves, GD; Eggers, HJ; Folkers, K; Furst, A; Koch, MA; Wilczynski, JJ | 1 |
| Halpern, B; Westley, JW | 1 |
| Kopiĭchuk, II | 1 |
| Naumov, AV; Nefedov, LI; Ostrovskiĭ, IuM | 1 |
| Gotoh, M; Hirano, T; Oka, K | 1 |
| Brown, D; Gammon, G; Moore, M; Sadeghi, R; Steel, J | 1 |
| Barbeito, L; Estevez, A; Peluffo, H; Stutzmann, JM | 1 |
| Furushiro, M; Hashimoto, S; Shibata, S; Shishido, Y; Tanabe, S; Tanaka, T; Watanabe, S; Yokokura, T | 1 |
| Akagi, H; Fujimura, T; Hayashi, N; Ichikawa, N; Sakamoto, K; Tada, Y; Yokozeki, Y | 1 |
| Carillon, C; Delpech, B; Ferrara, P; Gouldson, P; Le Fur, G; Legoux, P; Shire, D | 1 |
| Damas, AM; Merlini, G; Saraiva, MJ; Sebastião, MP | 1 |
| Chang, YC; Chou, MY | 1 |
| Ikeda, U; Lee, RT; Ohki, R; Shimada, K; Yamamoto, K | 1 |
| Auwerx, J; Bac, P; Blanchard, SG; Champy, MF; Desreumaux, P; Dubuquoy, L; Gelman, L; Leesnitzer, LM; Moras, D; Picard, F; Plunket, KD; Potier, N; Renaud, JP; Rocchi, S; Vamecq, J; Zeyer, D | 1 |
| Bode, HB; Höfle, G; Kroppenstedt, RM; Mahmud, T; Müller, R; Nordhoff, S; Silakowski, B; Xu, M | 1 |
| Chang, Z; Flatt, P; Gerwick, WH; Nguyen, VA; Sherman, DH; Willis, CL | 1 |
| Phillips, AJ; Sammakia, T; Zhang, Y | 1 |
| Hahm, KS; Lee, DG; Shin, SY | 1 |
| Sammakia, T; Zhang, Y | 1 |
| Ghadiri, MR; Horne, WS; Stout, CD; Yadav, MK | 1 |
| Gutmann, DH; Rong, R; Tang, X; Ye, K | 1 |
| Bode, HB; Gaitatzis, N; Mahmud, T; Müller, R; Wan, E; Wen, KW; Wenzel, SC | 1 |
| Gomathi, K; Jayakumar, R; Koteeswari, D; Murali, J | 1 |
| Hughes, RD; Mitry, RR; Morsy, MA; Thabrew, MI | 1 |
| Koelsch, R; Neubert, K; Stiebitz, B; Stöckel-Maschek, A | 1 |
| Keasling, JD; Muller, SJ; Wang, K | 1 |
| Hong, SJ; Wang, HZ; Wu, KY | 1 |
| Galonić, DP; Vaillancourt, FH; Walsh, CT | 1 |
| Flatt, PM; Gerwick, WH; McPhail, KL; O'Connell, SJ; Sherman, DH; Willis, CL; Zeller, G | 1 |
| Black, WC; Percival, MD | 1 |
| Baccarani, M; Bosi, C; Castagnetti, F; Cilloni, D; Colarossi, S; Giannoulia, P; Gnani, A; Iacobucci, I; Luatti, S; Martinelli, G; Marzocchi, G; Palandri, F; Paolini, S; Piccaluga, PP; Rondoni, M; Rosti, G; Saglio, G; Soverini, S; Testoni, N | 1 |
| Battelli, MG; Bolognesi, A; Contestabile, A; D'Alessandro, C; Farini, V; Monti, B; Polazzi, E; Stirpe, F | 1 |
| Adachi, K; Kanoh, K; Kasai, H; Katsuta, A; Matsuo, Y; Shin-Ya, K; Shizuri, Y; Yamori, T | 1 |
| Adachi, K; Imagawa, H; Kanoh, K; Matsuo, Y; Nishizawa, M; Shizuri, Y | 1 |
| Liang, G; Wei, H; Yang, H | 1 |
| Han, CG; Liu, YX; Sheng, L; Ye, P; Zhang, ZY | 1 |
| Cho, SH; Chun, HS; Endou, H; Kanai, Y; Kim, CS; Kim, DK; Lee, SY | 1 |
| Guan, Y; Jia, J; Liang, P; Wei, C | 1 |
| Abid-Essefi, S; Bacha, H; Golli, EE; Othmen, ZO | 1 |
| Meredith, SC; Orgel, JP; Sciarretta, KL; Tycko, R | 1 |
| Divoka, M; Divoky, V; Faber, E; Indrak, K; Jarosova, M; Mojzikova, R; Plachy, R; Rozmanova, S; Stastny, M | 1 |
| Bailey, MD; Bhardwaj, PK; Bordeleau, J; Bös, M; Bousquet, Y; Cordingley, MG; Duan, J; Forgione, P; Garneau, M; Ghiro, E; Gorys, V; Goudreau, N; Goulet, S; Halmos, T; Kawai, SH; Llinàs-Brunet, M; Naud, J; Poupart, MA; White, PW | 1 |
| Amad, M; Bethell, RC; Bolger, G; Cordingley, MG; Duan, J; Garneau, M; Kukolj, G; Lagacé, L; Llinàs-Brunet, M; Thibeault, D; White, PW | 1 |
| Benhamou, Y; Berg, T; Boecher, WO; Bonacini, M; Bourlière, M; Calleja, JL; Kukolj, G; Manns, MP; Pol, S; Scherer, J; Steinmann, G; Stern, JO; Trepo, C; White, PW; Wright, D; Yong, CL | 1 |
| Goudreau, N; Hucke, O; Lemke, CT; Llinàs-Brunet, M; Thibeault, D; White, PW; Zhao, S | 1 |
| Khungar, V; Poordad, F | 1 |
| Ciesek, S; Manns, MP; von Hahn, T | 1 |
| Angus, P; Arasteh, K; Asselah, T; Boecher, WO; Bronowicki, JP; Gane, E; Haefner, C; Heim, M; Kukolj, G; Larrey, D; Lohse, A; Müllhaupt, B; Nehmiz, G; Pol, S; Roberts, S; Schuchmann, M; Stern, JO; Zarski, JP; Zeuzem, S; Zoulim, F | 1 |
| Bassan, R; Bussini, A; Castagnetti, F; Gnani, A; Intermesoli, T; Rosti, G; Soverini, S; Spinelli, O | 1 |
| Amad, M; Bethell, RC; Bolger, G; Cordingley, MG; De Marte, J; Duan, J; Garneau, M; Jutras, M; Llinàs-Brunet, M; Montpetit, H; Otis, F; Rhéaume, M; White, PW; Yong, CL | 1 |
| Bousquet, C; Dansereau, N; Dô, F; Kukolj, G; Lagacé, L; Llinas-Brunet, M; Marquis, M; Massariol, MJ; Maurice, R; Spickler, C; Thibeault, D; Triki, I; White, PW; Zhao, S | 1 |
| Lok, AS; Sharma, P | 1 |
| Garcia, JG; Gupta, MP; Kim, G; Moreno-Vinasco, L; Pillai, VB; Samant, S; Sundaresan, NR | 1 |
| Kim, SJ; McAlpine, SR | 1 |
| Asselah, T; Bessone, F; Böcher, WO; Datsenko, Y; Fainboim, H; Ferenci, P; Heo, J; Kukolj, G; Lalezari, J; Leggett, B; Mauss, S; Nehmiz, G; Scherer, J; Steinmann, GG; Stern, JO; Sulkowski, MS | 1 |
| Angus, P; Arasteh, K; Asselah, T; Böcher, WO; Bronowicki, JP; Gane, E; Heim, M; Kukolj, G; Larrey, D; Lohse, AW; Mensa, FJ; Müllhaupt, B; Nehmiz, G; Pol, S; Roberts, S; Schuchmann, M; Stern, JO; Zarski, JP; Zeuzem, S; Zoulim, F | 1 |
| Lin, CC; McAlpine, SR; Tantisantisom, W | 1 |
| Berger, KL; Bethell, R; Cartier, M; Kukolj, G; Lagacé, L; Lawetz, C; Marquis, M; Scherer, J; Triki, I | 1 |
| Asselah, T; Böcher, WO; Bourlière, M; Bronowicki, JP; Buti, M; Gallivan, JP; Gane, EJ; Kukolj, G; Lohse, AW; Mensa, FJ; Müllhaupt, B; Roberts, SK; Schuchmann, M; Soriano, V; Stern, JO; Vinisko, R; Zeuzem, S | 1 |
| Kuboki, M; Nishiguchi, S; Omata, M; Sakai, Y; Sakamoto, W; Steinmann, G; Tsuda, Y; Tsunematsu, S; Urano, Y | 1 |
| Bichoupan, K; Dieterich, DT; Martel-Laferrière, V | 1 |
| Berger, KL; Böcher, WO; Cartier, M; Datsenko, Y; Kukolj, G; Marquis, M; Massariol, MJ; Scherer, J; Steinmann, G; Stern, JO; Triki, I | 1 |
| Busacca, CA; Gonnella, N; Li, Y; O'Brien, D; Ramsden, D; Taub, ME; Tweedie, DJ; Xu, J; Zhou, J | 1 |
| Laufer, NL; Rockstroh, JK | 1 |
| Chan, TS; Li, Y; Ramsden, D; Taub, ME; Tweedie, DJ | 1 |
| Chen, LZ; Li, Y; Ramsden, D; St George, R; Tweedie, DJ | 1 |
| Boccaccio, V; Bruno, S | 1 |
| Dieterich, DT; Martel-Laferrière, V | 1 |
| Asselah, T; Marcellin, P | 1 |
| Asselah, T; Halfon, P; Marcellin, P; Schinazi, R | 1 |
| Benhamou, Y; Shiffman, ML | 1 |
| Ford, N; Fortunak, J; Hill, A; Khoo, S; Simmons, B | 1 |
| Banerjee, S; Clayton, GM; Garavito, RM; Ghebreselasie, K; Hermanson, DJ; Marnett, LJ; Xu, S | 1 |
| Chen, LZ; Huang, F; Latli, B; Li, Y; Mandarino, D; Mao, Y; Rose, P; St George, R; Yong, CL | 1 |
| Shiffman, ML | 1 |
| Asselah, T; Berg, T; Böcher, WO; Datsenko, Y; Dieterich, D; Ferenci, P; Guyader, D; Larrey, D; Maieron, A; Mauss, S; Ozan, M; Ratziu, V; Schuchmann, M; Steinmann, G; Stern, JO | 1 |
| Agarwal, K; Austin, A; Barclay, ST; Brown, A; Dillon, JF; Dundas, P; Dusheiko, GM; Foster, GR; Fox, R; Hayes, PC; Leen, C; Miller, MH; Millson, C; Ryder, SD; Tait, J; Ustianowski, A | 1 |
| Chen, L; George, RS; Mao, Y; Norris, SH; Philip, E; Potchoiba, MJ; Wang, LQ; Wu, D | 1 |
| Böcher, WO; Hennecke, N; Kayser, A; Kukolj, G; Lohmann, V; Martin, B; Neumann-Haefelin, C; Thimme, R | 1 |
| Ballow, C; Battegay, M; Elgadi, M; Feifel, U; Fuhr, R; Girlich, B; Haschke, M; Kort, J; Lang, B; Li, Y; Sabo, JP; Schobelock, M | 1 |
| Asselah, T; Böcher, WO; Huang, Q; Li, Y; Mease, K; Nehmiz, G; Olson, S; Podila, L; Sane, RS; Steinmann, GG; Stern, JO; Taub, ME; Tweedie, D | 1 |
| Böcher, W; Buti, M; Buynak, RJ; Dufour, JF; Gallivan, JP; Mantry, P; Mensa, FJ; Soriano, V; Stern, JO; Taunk, J; Vinisko, R; Zeuzem, S | 1 |
| Elgadi, M; Halabi, A; Huang, F; Lang, B; Moschetti, V; Petersen-Sylla, M; Yong, CL | 1 |
| Elgadi, M; Garcia, J; Huang, F; Joseph, D; Rose, P; Schultz, A; Strelkowa, N | 1 |
| Adeniji, A; Elgadi, M; Huang, F; Joseph, D; Riesenberg, RR; Schobelock, MJ; Vince, BD; Webster, LR | 1 |
| Elgadi, M; Huang, F; Lang, B; Sabo, JP | 1 |
| Ballow, C; Battegay, M; Chan, TS; Cooper, C; Girlich, B; Haschke, M; Kashuba, AD; Kort, J; Lang, B; Li, Y; O'Brien, D; Sabo, JP; Seibert, E; Ting, N; Tweedie, D; Zhang, W | 1 |
| Angus, P; Asselah, T; Böcher, W; Bourlière, M; Bronowicki, JP; Buti, M; Gallivan, JP; Gane, EJ; Lohse, AW; Manns, M; Mensa, FJ; Müllhaupt, B; Roberts, S; Sabo, JP; Schuchmann, M; Soriano, V; Stern, JO; Stickel, F; Voss, F; Zeuzem, S | 1 |
| Agarwal, K; Asselah, T; Bourlière, M; Calinas, F; Crespo, J; Datsenko, Y; Dufour, JF; Ferenci, P; Forton, D; Foster, GR; Garcia, M; Kukolj, G; Maevskaya, M; Morano, LE; Moreno, C; Nishiguchi, S; Omata, M; Ouzan, D; Quinson, AM; Sarrazin, C; Scherer, J; Schuchmann, M; Stern, JO; Zehnter, E; Zeuzem, S | 1 |
| Agarwal, K; Barnabas, A | 1 |
| Arastéh, K; Bhagani, S; Dieterich, D; Guardiola, JM; Ingiliz, P; Jain, MK; Kort, J; Laguno, M; Manero, M; Nelson, M; Rockstroh, JK; Soriano, V; Stern, JO; Tural, C; Vinisko, R | 1 |
| Kanda, T; Omata, M; Yokosuka, O | 1 |
| Campagna, D; Demma, S | 1 |
| Ambrosioni, J; Aouri, M; Böni, J; Cavassini, M; Decosterd, L; Fehr, J; Furrer, H; Günthard, HF; Haubitz, S; Kovari, H; Ledergerber, B; Metzner, KJ; Rauch, A; Schaerer, V; Schmid, P; Stoeckle, M | 1 |
| Berger, KL; Kukolj, G; Quinson, AM; Ranga, M; Scherer, J; Sha, N; Stern, JO | 1 |
| Asselah, T; Bourlière, M; Dufour, JF; Ferenci, P; Forton, D; Foster, GR; García-Samaniego, J; Maevskaya, M; Mantry, P; Oliveira, C; Quinson, AM; Sha, N; Stern, JO; Warner, N; Wright, D; Wright, M; Yoshida, EM | 1 |
| Asselah, T; Baum, P; Böcher, WO; Bourlière, M; Bronowicki, JP; Buti, M; Gallivan, JP; Gane, EJ; Lohse, AW; Mensa, FJ; Müllhaupt, B; Roberts, SK; Schuchmann, M; Soriano, V; Stern, JO; Voss, F; Zeuzem, S | 1 |
| Elgadi, M; Gießmann, T; Huang, F; Lang, B; Wu, J | 1 |
| Angus, P; Böcher, W; Buti, M; Buynak, RJ; Dufour, JF; Kadus, W; Mantry, P; Mensa, FJ; Pockros, PJ; Soriano, V; Stern, JO; Vinisko, R; Wright, D; Zeuzem, S | 1 |
| Busacca, CA; Davis, M; Ding, A; Gonnella, NC; Grupe, J; Herfurth, L; Jones, PJ; Li, G; Niemann, M; Offerdahl, T; Reckzügel, G; Reddig, T; Roos, H; Saha, A; Wagner, K; Werthmann, U; Wu, JP; Zhang, L | 1 |
| Berger, KL; Côté-Martin, A; Kukolj, G; Marquis, M; Mensa, FJ; Nelson, DR; Sarrazin, C; Scherer, J; Sha, N; Stern, JO; Vinisko, R | 1 |
| Hannongbua, S; Kungwan, N; Meeprasert, A; Rungrotmongkol, T | 1 |
| Bai, X; Calleja, JL; Forns, X; Garcia-Samaniego, J; Kaste, R; Manns, M; Sarrazin, C; Stern, JO; Wu, J | 1 |
| Elgadi, M; Haertter, S; Huang, F; Kammerer, KP; Koenen, R; Marzin, K; Quinson, AM; Strelkowa, N | 1 |
| Du, W; Gou, X; Hu, J; Liang, L; Liu, W; Zuo, K | 1 |
| Huang, F; Rowland, L; Sabo, JP; Schultz, A; Trampisch, M; Voelk, C | 1 |
| Huttunen, J; Huttunen, KM; Markowicz-Piasecka, M; Montaser, A | 1 |
| Elgadi, M; Haertter, S; Huang, F; Kammerer, KP; Koenen, R; Marzin, K; Strelkowa, N | 1 |
14 review(s) available for thiazoles and leucine
| Article | Year |
|---|---|
The consequences of lysosomotropism on the design of selective cathepsin K inhibitors.
Topics: Animals; Benzamides; Biphenyl Compounds; Cathepsin K; Cathepsins; Crystallography, X-Ray; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Drug Design; Humans; Leucine; Lysosomes; Models, Molecular; Molecular Structure; Peptides; Thiazoles | 2006 |
Emerging therapeutic options in hepatitis C virus infection.
Topics: Aminoisobutyric Acids; Cyclopropanes; Drug Resistance, Viral; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 3-Ring; Humans; Indoles; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Oligopeptides; Proline; Quinolines; Simeprevir; Sulfonamides; Thiazoles; Treatment Outcome; Viral Load; Virus Replication | 2011 |
Second-wave protease inhibitors: choosing an heir.
Topics: Aminoisobutyric Acids; Antiviral Agents; Carrier Proteins; Cyclopropanes; Hepatitis C; Heterocyclic Compounds, 3-Ring; Humans; Intracellular Signaling Peptides and Proteins; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Simeprevir; Sulfonamides; Thiazoles; Viral Nonstructural Proteins | 2011 |
Hepatitis C direct-acting antiviral agents: changing the paradigm of hepatitis C treatment in HIV-infected patients.
Topics: Aminoisobutyric Acids; Antiviral Agents; Coinfection; Hepatitis C; Heterocyclic Compounds, 3-Ring; HIV Infections; Humans; Interferons; Leucine; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Simeprevir; Sulfonamides; Thiazoles; Viral Nonstructural Proteins | 2014 |
Faldaprevir (BI 201335) for the treatment of hepatitis C in patients co-infected with HIV.
Topics: Aminoisobutyric Acids; Antiviral Agents; Biological Availability; Clinical Trials as Topic; Coinfection; Drug Administration Schedule; Genotype; Hepacivirus; Hepatitis C, Chronic; HIV; HIV Infections; Humans; Leucine; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Thiazoles; Virus Replication | 2014 |
Management of HCV patients with cirrhosis with direct acting antivirals.
Topics: Algorithms; Aminoisobutyric Acids; Antiviral Agents; Clinical Trials as Topic; Drug Therapy, Combination; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 3-Ring; Humans; Leucine; Liver Cirrhosis; Oligopeptides; Proline; Quinolines; Simeprevir; Sofosbuvir; Sulfonamides; Thiazoles; Time Factors; Uridine Monophosphate | 2014 |
Treating HCV in HIV 2013: on the cusp of change.
Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Coinfection; Drug Interactions; Drug Therapy, Combination; Hepacivirus; Hepatitis C; HIV Infections; Humans; Imidazoles; Leucine; Oligopeptides; Proline; Pyrrolidines; Quinolines; Sofosbuvir; Thiazoles; Treatment Outcome; Uridine Monophosphate; Valine | 2014 |
Second-wave IFN-based triple therapy for HCV genotype 1 infection: simeprevir, faldaprevir and sofosbuvir.
Topics: Aminoisobutyric Acids; Antiviral Agents; Clinical Trials as Topic; Drug Approval; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 3-Ring; Humans; Leucine; Oligopeptides; Proline; Quinolines; Simeprevir; Sofosbuvir; Sulfonamides; Thiazoles; Time Factors; Uridine Monophosphate | 2014 |
HCV direct-acting antiviral agents: the best interferon-free combinations.
Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Clinical Trials as Topic; Disease Eradication; Drug Discovery; Drug Therapy, Combination; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 3-Ring; Humans; Imidazoles; Interferon-alpha; Isoquinolines; Leucine; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Pyrrolidines; Quinolines; Recombinant Proteins; Ribavirin; Simeprevir; Sofosbuvir; Sulfonamides; Thiazoles; Uridine Monophosphate; Valine; Viral Nonstructural Proteins; Virus Replication | 2014 |
HCV F1/F2 patients: treat now or continue to wait.
Topics: Aminoisobutyric Acids; Antiviral Agents; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C, Chronic; Heterocyclic Compounds, 3-Ring; Humans; Leucine; Oligopeptides; Proline; Quinolines; Ribavirin; Simeprevir; Sofosbuvir; Sulfonamides; Thiazoles; Treatment Outcome; Uridine Monophosphate | 2014 |
Hepatitis C virus therapy in the direct acting antiviral era.
Topics: Aminoisobutyric Acids; Antiviral Agents; Drug Therapy, Combination; Hepatitis C, Chronic; Humans; Interferon-alpha; Leucine; Oligopeptides; Proline; Quinolines; Ribavirin; Sofosbuvir; Thiazoles; Uridine Monophosphate | 2014 |
Faldaprevir for the treatment of genotype-1 hepatitis C virus.
Topics: Aminoisobutyric Acids; Antiviral Agents; Clinical Trials as Topic; Drug Therapy, Combination; Genotype; Hepacivirus; Hepatitis C; Humans; Interferons; Leucine; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Quinolines; Ribavirin; Thiazoles | 2015 |
Faldaprevir for the treatment of hepatitis C.
Topics: Aminoisobutyric Acids; Antiviral Agents; Drug Therapy, Combination; Hepacivirus; Hepatitis C; Humans; Interferon-alpha; Leucine; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Thiazoles; Viral Nonstructural Proteins | 2015 |
Faldaprevir for the treatment of hepatitis C.
Topics: Aminoisobutyric Acids; Animals; Antiviral Agents; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Discovery; Drug Interactions; Hepatitis C; Humans; Leucine; Molecular Structure; Oligopeptides; Proline; Quinolines; Thiazoles; Tissue Distribution; Treatment Outcome; Viral Nonstructural Proteins | 2015 |
29 trial(s) available for thiazoles and leucine
| Article | Year |
|---|---|
Potency, safety, and pharmacokinetics of the NS3/4A protease inhibitor BI201335 in patients with chronic HCV genotype-1 infection.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Carrier Proteins; Double-Blind Method; Drug Resistance, Viral; Female; Hepacivirus; Hepatitis C; Humans; Interferon alpha-2; Interferon-alpha; Intracellular Signaling Peptides and Proteins; Leucine; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Quinolines; Recombinant Proteins; Ribavirin; Thiazoles; Viral Load; Viral Nonstructural Proteins | 2011 |
Efficacy of the protease inhibitor BI 201335, polymerase inhibitor BI 207127, and ribavirin in patients with chronic HCV infection.
Topics: Acrylates; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Leucine; Male; Middle Aged; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Ribavirin; RNA-Dependent RNA Polymerase; RNA, Viral; Thiazoles; Treatment Outcome; Viral Load; Viral Nonstructural Proteins | 2011 |
Faldaprevir combined with pegylated interferon alfa-2a and ribavirin in treatment-naïve patients with chronic genotype 1 HCV: SILEN-C1 trial.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Carrier Proteins; Double-Blind Method; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Intracellular Signaling Peptides and Proteins; Leucine; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Recombinant Proteins; Ribavirin; Thiazoles; Viral Nonstructural Proteins | 2013 |
Faldaprevir (BI 201335), deleobuvir (BI 207127) and ribavirin oral therapy for treatment-naive HCV genotype 1: SOUND-C1 final results.
Topics: Acrylates; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Drug Administration Schedule; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Interferon-alpha; Leucine; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Recombinant Proteins; Ribavirin; Thiazoles; Treatment Outcome; Viral Load | 2013 |
Viral resistance in hepatitis C virus genotype 1-infected patients receiving the NS3 protease inhibitor Faldaprevir (BI 201335) in a phase 1b multiple-rising-dose study.
Topics: Aminoisobutyric Acids; Antiviral Agents; Cell Line; Genotype; Genotyping Techniques; Hepacivirus; Humans; Leucine; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Thiazoles; Viral Nonstructural Proteins | 2013 |
Faldaprevir and deleobuvir for HCV genotype 1 infection.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; DNA-Directed RNA Polymerases; Enzyme Inhibitors; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Leucine; Male; Middle Aged; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Thiazoles; Viral Load | 2013 |
Safety and efficacy of faldaprevir with pegylated interferon alfa-2a and ribavirin in Japanese patients with chronic genotype-1 hepatitis C infection.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Asian People; Double-Blind Method; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Japan; Leucine; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Recombinant Proteins; Ribavirin; Thiazoles; Time Factors; Treatment Outcome | 2014 |
Mass balance and metabolite profiling of steady-state faldaprevir, a hepatitis C virus NS3/4 protease inhibitor, in healthy male subjects.
Topics: Adolescent; Adult; Aminoisobutyric Acids; Hepacivirus; Humans; Leucine; Male; Middle Aged; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Thiazoles; Young Adult | 2014 |
SILEN-C3, a phase 2 randomized trial with faldaprevir plus pegylated interferon α-2a and ribavirin in treatment-naive hepatitis C virus genotype 1-infected patients.
Topics: Adolescent; Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Carrier Proteins; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C; Humans; Interferon-alpha; Intracellular Signaling Peptides and Proteins; Leucine; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Recombinant Proteins; Ribavirin; RNA, Viral; Thiazoles; Viral Nonstructural Proteins; Young Adult | 2014 |
Restoration of HCV-specific CD8+ T cell function by interferon-free therapy.
Topics: Acrylates; Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; CD8-Positive T-Lymphocytes; Cell Proliferation; Cells, Cultured; Contraindications; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C, Chronic; Humans; In Vitro Techniques; Interferon alpha-2; Interferon-alpha; Leucine; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Recombinant Proteins; Ribavirin; Thiazoles; Treatment Outcome; Virus Replication | 2014 |
Clinical assessment of potential drug interactions of faldaprevir, a hepatitis C virus protease inhibitor, with darunavir/ritonavir, efavirenz, and tenofovir.
Topics: Adenine; Adult; Alkynes; Aminoisobutyric Acids; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Coinfection; Cyclopropanes; Darunavir; Drug Interactions; Female; Healthy Volunteers; Hepacivirus; Hepatitis C; HIV Infections; HIV-1; Humans; Leucine; Male; Middle Aged; Oligopeptides; Organophosphonates; Proline; Protease Inhibitors; Quinolines; Ritonavir; Sulfonamides; Tenofovir; Thiazoles; Young Adult | 2014 |
Mechanisms underlying benign and reversible unconjugated hyperbilirubinemia observed with faldaprevir administration in hepatitis C virus patients.
Topics: Aminoisobutyric Acids; Animals; Bilirubin; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Double-Blind Method; Glucuronosyltransferase; Hepacivirus; Hepatitis C; Hepatocytes; Humans; Hyperbilirubinemia; Leucine; Liver; Macaca mulatta; Multicenter Studies as Topic; Multidrug Resistance-Associated Protein 2; Oligopeptides; Proline; Quinolines; Randomized Controlled Trials as Topic; Rats; Thiazoles | 2014 |
Interferon-free treatment of chronic hepatitis C with faldaprevir, deleobuvir and ribavirin: SOUND-C3, a Phase 2b study.
Topics: Acrylates; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Drug Therapy, Combination; Hepatitis C, Chronic; Humans; Leucine; Oligopeptides; Proline; Quinolines; Ribavirin; RNA, Viral; Thiazoles; Treatment Outcome | 2015 |
Pharmacokinetics, safety, and tolerability of faldaprevir in patients with renal impairment.
Topics: Adult; Aged; Aminoisobutyric Acids; Biological Availability; Female; Half-Life; Hepatitis C; Humans; Leucine; Male; Middle Aged; Oligopeptides; Proline; Quinolines; Renal Insufficiency; Thiazoles | 2015 |
Effect of faldaprevir on raltegravir pharmacokinetics in healthy volunteers.
Topics: Adult; Aminoisobutyric Acids; Drug Administration Schedule; Drug Interactions; Female; Genotype; Glucuronosyltransferase; Healthy Volunteers; HIV Integrase Inhibitors; Humans; Leucine; Male; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Raltegravir Potassium; Thiazoles; Young Adult | 2015 |
Effect of steady-state faldaprevir on the pharmacokinetics of steady-state methadone and buprenorphine-naloxone in subjects receiving stable addiction management therapy.
Topics: Administration, Oral; Adult; Aminoisobutyric Acids; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Drug Interactions; Female; Humans; Leucine; Male; Methadone; Middle Aged; Oligopeptides; Proline; Quinolines; Substance Withdrawal Syndrome; Substance-Related Disorders; Thiazoles; Young Adult | 2015 |
Effect of the hepatitis C virus protease inhibitor faldaprevir on the pharmacokinetics of an oral contraceptive containing ethinylestradiol and levonorgestrel in healthy female volunteers.
Topics: Administration, Oral; Adolescent; Adult; Aminoisobutyric Acids; Area Under Curve; Bilirubin; Contraceptives, Oral, Combined; Drug Combinations; Drug Interactions; Ethinyl Estradiol; Female; Half-Life; Humans; Leucine; Levonorgestrel; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Thiazoles; Viral Nonstructural Proteins; Young Adult | 2015 |
Interactions of the hepatitis C virus protease inhibitor faldaprevir with cytochrome P450 enzymes: in vitro and in vivo correlation.
Topics: Adolescent; Adult; Aminoisobutyric Acids; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Female; Healthy Volunteers; Hepatitis C; Humans; In Vitro Techniques; Isoenzymes; Leucine; Male; Microsomes, Liver; Midazolam; Middle Aged; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Thiazoles; Warfarin; Young Adult | 2015 |
Efficacy and safety of faldaprevir, deleobuvir, and ribavirin in treatment-naive patients with chronic hepatitis C virus infection and advanced liver fibrosis or cirrhosis.
Topics: Acrylates; Adult; Aged; Aged, 80 and over; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Female; Hepatitis C, Chronic; Humans; Leucine; Liver Cirrhosis; Male; Middle Aged; Oligopeptides; Proline; Quinolines; Ribavirin; Thiazoles; Young Adult | 2015 |
STARTVerso1: A randomized trial of faldaprevir plus pegylated interferon/ribavirin for chronic HCV genotype-1 infection.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Double-Blind Method; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Leucine; Male; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Recombinant Proteins; Ribavirin; RNA, Viral; Thiazoles | 2015 |
Faldaprevir and pegylated interferon α-2a/ribavirin in individuals co-infected with hepatitis C virus genotype-1 and HIV.
Topics: Adolescent; Adult; Aged; Aminoisobutyric Acids; Anti-Retroviral Agents; Antiviral Agents; Drug Therapy, Combination; Hepatitis C, Chronic; HIV Infections; Humans; Interferon-alpha; Leucine; Middle Aged; Oligopeptides; Polyethylene Glycols; Proline; Quinolines; Recombinant Proteins; Ribavirin; Thiazoles; Treatment Outcome; Viral Load; Viremia; Young Adult | 2015 |
Baseline Polymorphisms and Emergence of Drug Resistance in the NS3/4A Protease of Hepatitis C Virus Genotype 1 following Treatment with Faldaprevir and Pegylated Interferon Alpha 2a/Ribavirin in Phase 2 and Phase 3 Studies.
Topics: Amino Acid Substitution; Aminoisobutyric Acids; Antiviral Agents; Carrier Proteins; Double-Blind Method; Drug Resistance, Viral; Gene Expression; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Intracellular Signaling Peptides and Proteins; Leucine; Mutation; Oligopeptides; Polyethylene Glycols; Polymorphism, Genetic; Proline; Quinolines; Recombinant Proteins; Ribavirin; Thiazoles; Treatment Outcome; Viral Nonstructural Proteins | 2015 |
Open-label study of faldaprevir plus peginterferon and ribavirin in hepatitis C virus genotype 1-infected patients who failed placebo plus peginterferon and ribavirin.
Topics: Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Leucine; Male; Middle Aged; Oligopeptides; Placebos; Proline; Quinolines; Ribavirin; Salvage Therapy; Thiazoles; Treatment Outcome | 2016 |
ITPA Genotypes Predict Anemia but Do Not Affect Virological Response with Interferon-Free Faldaprevir, Deleobuvir, and Ribavirin for HCV Infection.
Topics: Acrylates; Aminoisobutyric Acids; Anemia; Antiviral Agents; Benzimidazoles; Female; Genotype; Hepacivirus; Hepatitis C; Humans; Interferons; Leucine; Male; Middle Aged; Oligopeptides; Polymorphism, Single Nucleotide; Proline; Pyrophosphatases; Quinolines; Real-Time Polymerase Chain Reaction; Ribavirin; Thiazoles | 2015 |
Investigation of the effect of food and omeprazole on the relative bioavailability of a single oral dose of 240 mg faldaprevir, a selective inhibitor of HCV NS3/4 protease, in an open-label, randomized, three-way cross-over trial in healthy participants.
Topics: Administration, Oral; Adult; Aminoisobutyric Acids; Antiviral Agents; Area Under Curve; Biological Availability; Cross-Over Studies; Female; Food-Drug Interactions; Healthy Volunteers; Hepacivirus; Humans; Leucine; Male; Metabolic Clearance Rate; Middle Aged; Oligopeptides; Omeprazole; Proline; Protease Inhibitors; Proton Pump Inhibitors; Quinolines; Risk Factors; Thiazoles; Viral Nonstructural Proteins; Young Adult | 2016 |
Short article: Faldaprevir, deleobuvir and ribavirin in IL28B non-CC patients with HCV genotype-1a infection included in the SOUND-C3 phase 2b study.
Topics: Acrylates; Adult; Aminoisobutyric Acids; Antiviral Agents; Australia; Benzimidazoles; Drug Administration Schedule; Drug Therapy, Combination; Europe; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Interferons; Interleukins; Leucine; Male; Middle Aged; Oligopeptides; Phenotype; Proline; Protease Inhibitors; Quinolines; Ribavirin; RNA, Viral; Sustained Virologic Response; Thiazoles; Time Factors; Treatment Outcome; United States | 2016 |
HCVerso3: An Open-Label, Phase IIb Study of Faldaprevir and Deleobuvir with Ribavirin in Hepatitis C Virus Genotype-1b-Infected Patients with Cirrhosis and Moderate Hepatic Impairment.
Topics: Acrylates; Adolescent; Adult; Aged; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Drug Therapy, Combination; Female; Follow-Up Studies; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Leucine; Liver Cirrhosis; Male; Middle Aged; Oligopeptides; Prognosis; Proline; Quinolines; Ribavirin; RNA, Viral; Thiazoles; Viral Load; Young Adult | 2016 |
Effect of Steady-State Faldaprevir on Pharmacokinetics of Atorvastatin or Rosuvastatin in Healthy Volunteers: A Prospective Open-Label, Fixed-Sequence Crossover Study.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Atorvastatin; Cross-Over Studies; Drug Interactions; Female; Healthy Volunteers; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leucine; Male; Middle Aged; Oligopeptides; Proline; Pyrimidines; Quinolines; Rosuvastatin Calcium; Serine Proteinase Inhibitors; Sulfonamides; Thiazoles | 2017 |
Pharmacokinetic Interaction between Faldaprevir and Cyclosporine or Tacrolimus in Healthy Volunteers: A Prospective, Open-Label, Fixed-Sequence, Crossover Study.
Topics: Adolescent; Adult; Aminoisobutyric Acids; Antiviral Agents; Area Under Curve; Cross-Over Studies; Cyclosporine; Drug Interactions; Female; Graft Rejection; Healthy Volunteers; Hepatitis C; Humans; Immunosuppressive Agents; Leucine; Liver Transplantation; Male; Middle Aged; Oligopeptides; Proline; Prospective Studies; Quinolines; Secondary Prevention; Tacrolimus; Thiazoles; Young Adult | 2018 |
74 other study(ies) available for thiazoles and leucine
| Article | Year |
|---|---|
[Incorporation of radioactive protein and RNA precursors into animal liver polysomes under hydroxythiamine injection].
Topics: Animals; Leucine; Liver; Mice; Orotic Acid; Oxythiamine; Polyribosomes; Proteins; Rats; RNA, Ribosomal; Thiazoles | 1978 |
The variability of human lambda-chain constant regions and some relationships to V-regions sequences.
Topics: Alanine; Amino Acid Sequence; Chromatography, Gel; Chromatography, Ion Exchange; Cystine; Electrophoresis, Paper; Glutamates; Glycine; Humans; Immunoglobulin lambda-Chains; Immunoglobulin Light Chains; Isoleucine; Leucine; Peptides; Proline; Serine; Thiazoles; Threonine; Valine | 1976 |
Assessment of cytotoxicity assays as predictors of ocular irritation of pharmaceuticals.
Topics: Animals; Cells, Cultured; Cornea; Drug-Related Side Effects and Adverse Reactions; Epithelium; Leucine; Neutral Red; Rabbits; Tetrazolium Salts; Thiazoles; Toxicology | 1992 |
Antitrypanosomal action of cis-diamminedichloroplatinum (II) analogs.
Topics: Animals; Benzothiazoles; Cell Nucleus; Cisplatin; DNA; Leucine; Microscopy, Electron; Organoids; Protein Biosynthesis; RNA; Thiazoles; Thymidine; Tranylcypromine; Trypanosoma cruzi; Uridine; Vacuoles | 1987 |
Structural specificities for the active transport system of thiamine in rat small intestine.
Topics: Alanine; Animals; Binding Sites; Biological Transport, Active; Electrophoresis, Paper; Fructose; Galactose; Glucose; Hydrogen-Ion Concentration; Intestine, Small; Leucine; Male; Models, Chemical; Pyrimidines; Rats; Structure-Activity Relationship; Sulfur; Sulfur Radioisotopes; Thiamine; Thiamine Pyrophosphate; Thiazoles | 1974 |
First enzyme of histidine biosynthesis and repression control of histidyl-transfer ribonucleic acid synthetase of Salmonella typhimurium.
Topics: Amino Acids; Amino Acyl-tRNA Synthetases; Carbon Radioisotopes; Cell-Free System; Enzyme Repression; Histidine; Leucine; Mutation; Operon; Salmonella typhimurium; Thiazoles; Triazoles | 1974 |
Effect of the bladder carcinogen N-(4-(5-nitro-2-furyl)-2-thiazolyl)formamide on nucleic acids and total protein content of bladder epithelium undergoing malignant change.
Topics: Animals; Autoradiography; Carcinogens; Cell Nucleus; Cytoplasm; DNA; Formamides; Leucine; Male; Microscopy, Electron; Nitrofurans; Protein Biosynthesis; Rats; RNA; Spectrophotometry; Thiazoles; Thymidine; Tritium; Uridine; Urinary Bladder; Urinary Bladder Neoplasms | 1974 |
A radioimmunoassay for parathyroid hormone in rat parathyroid gland.
Topics: Animals; Calcium; Cattle; Chromatography, Gel; Cross Reactions; Diet; Guinea Pigs; Immune Sera; Injections, Intraperitoneal; Iodine Radioisotopes; Kidney; Leucine; Male; Parathyroid Glands; Parathyroid Hormone; Radioimmunoassay; Rats; Secretory Rate; Stimulation, Chemical; Thiazoles; Time Factors | 1974 |
Effect of amino acids and purine bases on thiamine synthesis by Escherichia coli.
Topics: Adenine; Amino Acids; Aspartic Acid; Culture Media; Cystine; Cytosine; Escherichia coli; Glutamates; Glycine; Guanine; Histidine; Hypoxanthines; Inositol; Isoleucine; Leucine; Methionine; Phenylalanine; Proline; Purines; Serine; Thiamine; Thiazoles; Threonine; Thymine; Tyrosine; Uracil; Valine | 1968 |
Rhodanine: a selective inhibitor of the multiplication of echovirus 12.
Topics: Animals; Antiviral Agents; Culture Techniques; Enterovirus B, Human; Haplorhini; Kidney; Leucine; Thiazoles; Tritium; Virus Cultivation; Virus Replication | 1970 |
Optical resolution of D,L amino acids by gas chromatography and mass spectrometry.
Topics: Alanine; Amino Acids; Aminobutyrates; Chemical Phenomena; Chemistry, Physical; Chromatography, Gas; Glycine; Leucine; Proline; Spectrum Analysis; Thiazoles | 1965 |
[Synthesis and characteristics of rhodanines, produced from leucine].
Topics: Leucine; Thiazoles | 1966 |
[Some features of [1-14C] leucine exchange in rat liver during acute oxythiamine avitaminosis].
Topics: Animals; Kinetics; Leucine; Liver; Male; Oxythiamine; Rats; RNA, Transfer; RNA, Transfer, Amino Acyl; Thiamine Deficiency; Thiazoles | 1982 |
Natural flavonoids and lignans are potent cytostatic agents against human leukemic HL-60 cells.
Topics: Antineoplastic Agents; Cell Division; Drug Screening Assays, Antitumor; Flavonoids; Humans; Leucine; Leukemia, Promyelocytic, Acute; Leukemia, T-Cell; Lignans; Lymphocyte Activation; Lymphocytes; Tetrazolium Salts; Thiazoles; Thymidine; Tumor Cells, Cultured; Uridine | 1994 |
Detection of interleukin-1 signal transduction inhibitors: action of protein kinase inhibitors.
Topics: Cell Division; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Humans; Interleukin-1; Interleukin-6; KB Cells; Leucine; Molecular Weight; Protein Kinase C; Protein Kinase Inhibitors; Receptor Protein-Tyrosine Kinases; Signal Transduction; Tetrazolium Salts; Thiazoles | 1995 |
Riluzole promotes survival of rat motoneurons in vitro by stimulating trophic activity produced by spinal astrocyte monolayers.
Topics: Animals; Astrocytes; Cell Survival; Cells, Cultured; Culture Media, Conditioned; DNA; Immunohistochemistry; Leucine; Motor Neurons; Nerve Tissue Proteins; Neuroprotective Agents; Rats; Receptors, Nerve Growth Factor; Riluzole; Spinal Cord; Thiazoles; Thymidine | 1997 |
ZTTA, a prolyl endopeptidase inhibitor, potentiates the arginine-vasopressin-induced incorporation of [14C]leucine in rat amygdaloid and cortical slices.
Topics: Amygdala; Animals; Arginine Vasopressin; Carbon Radioisotopes; Enzyme Inhibitors; Leucine; Male; Peptide Biosynthesis; Prolyl Oligopeptidases; Rats; Rats, Wistar; Serine Endopeptidases; Thiazoles | 1999 |
Chemical induction of disease resistance in rice is correlated with the expression of a gene encoding a nucleotide binding site and leucine-rich repeats.
Topics: Amino Acid Sequence; Binding Sites; Chromosome Mapping; Conserved Sequence; DNA-Binding Proteins; Gene Expression Regulation, Plant; Genes, Plant; Immunity, Innate; Leucine; Molecular Sequence Data; Oryza; Plant Diseases; Plant Proteins; Polymorphism, Restriction Fragment Length; Repetitive Sequences, Amino Acid; Sequence Alignment; Sequence Homology, Amino Acid; Thiazoles | 1999 |
Contrasting roles of leu(356) in the human CCK(1) receptor for antagonist SR 27897 and agonist SR 146131 binding.
Topics: Animals; Binding Sites; COS Cells; Hormone Antagonists; Humans; Indoleacetic Acids; Indoles; Leucine; Point Mutation; Receptors, Cholecystokinin; Sincalide; Thiazoles | 1999 |
The molecular interaction of 4'-iodo-4'-deoxydoxorubicin with Leu-55Pro transthyretin 'amyloid-like' oligomer leading to disaggregation.
Topics: Amino Acid Substitution; Amyloidosis; Benzothiazoles; Crystallization; Doxorubicin; Humans; Iodine; Leucine; Models, Molecular; Prealbumin; Proline; Protein Binding; Protein Structure, Secondary; Thiazoles; X-Ray Diffraction | 2000 |
Cytotoxicity of fluoride on human pulp cell cultures in vitro.
Topics: Analysis of Variance; Bisbenzimidazole; Cariostatic Agents; Cell Division; Cells, Cultured; Colorimetry; Coloring Agents; Dental Pulp; Enzyme-Linked Immunosorbent Assay; Fluorescent Dyes; Fluorides; Humans; Leucine; Mitochondria; Protein Biosynthesis; Proteins; Radiopharmaceuticals; Reproducibility of Results; Statistics as Topic; Tetrazolium Salts; Thiazoles; Thymidine; Tritium | 2001 |
Peroxisome proliferator-activated receptor gamma activators inhibit cardiac hypertrophy in cardiac myocytes.
Topics: Angiotensin II; Animals; Animals, Newborn; Biological Transport; Cardiomegaly; Cells, Cultured; Chromans; Heart; Leucine; Myocardium; Natriuretic Peptide, Brain; NF-kappa B; Phenylephrine; Prostaglandin D2; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Stress, Mechanical; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2001 |
A unique PPARgamma ligand with potent insulin-sensitizing yet weak adipogenic activity.
Topics: Adipocytes; Amino Acids; Animals; Binding Sites; Blood Glucose; Body Weight; Cell Differentiation; Cell Line; Dose-Response Relationship, Drug; Fluorenes; Gene Expression Regulation; Genes, Reporter; Hypoglycemic Agents; Insulin Resistance; Leucine; Ligands; Male; Mice; Mice, Inbred Strains; Molecular Structure; Protein Binding; Protein Conformation; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Rosiglitazone; Spectrometry, Mass, Electrospray Ionization; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Tyrosine | 2001 |
A novel biosynthetic pathway providing precursors for fatty acid biosynthesis and secondary metabolite formation in myxobacteria.
Topics: Bacterial Proteins; Cloning, Molecular; Coenzyme A; DNA; Fatty Acids; Leucine; Magnetic Resonance Spectroscopy; Methacrylates; Models, Chemical; Stigmatella aurantiaca; Thiazoles; Valerates | 2002 |
The barbamide biosynthetic gene cluster: a novel marine cyanobacterial system of mixed polyketide synthase (PKS)-non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Binding Sites; Cyanobacteria; DNA, Bacterial; Gene Order; Genes, Bacterial; Genomic Library; Leucine; Molecular Sequence Data; Multienzyme Complexes; Multigene Family; Peptide Synthases; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Thiazoles | 2002 |
Highly selective asymmetric acetate aldol reactions of an N-acetyl thiazolidinethione reagent.
Topics: Aldehydes; Boron Compounds; Chemistry, Organic; Indicators and Reagents; Leucine; Molecular Structure; Stereoisomerism; Thiazoles; Valine | 2004 |
Structure and fungicidal activity of a synthetic antimicrobial peptide, P18, and its truncated peptides.
Topics: Animals; Antifungal Agents; Antimicrobial Cationic Peptides; Aspergillus; Candida albicans; Circular Dichroism; Fusarium; Gene Deletion; Leucine; Magainins; Peptides; Proline; Protein Conformation; Protein Structure, Tertiary; Structure-Activity Relationship; Tetrazolium Salts; Thiazoles; Trichosporon; Xenopus; Xenopus Proteins | 2004 |
Synthesis of a new N-acetyl thiazolidinethione reagent and its application to a highly selective asymmetric acetate aldol reaction.
Topics: Aldehydes; Chemistry, Organic; Indicators and Reagents; Leucine; Molecular Structure; Sparteine; Stereoisomerism; Thiazoles | 2004 |
Heterocyclic peptide backbone modifications in an alpha-helical coiled coil.
Topics: Amino Acid Sequence; Amino Acids; Crystallography, X-Ray; Dipeptides; DNA-Binding Proteins; Hydrogen Bonding; Leucine; Models, Molecular; Molecular Sequence Data; Protein Kinases; Protein Structure, Secondary; Saccharomyces cerevisiae Proteins; Thiazoles | 2004 |
Neurofibromatosis 2 (NF2) tumor suppressor merlin inhibits phosphatidylinositol 3-kinase through binding to PIKE-L.
Topics: Adenoviridae; Animals; Cell Line; Cell Proliferation; Coloring Agents; Glutathione Transferase; GTP-Binding Proteins; GTPase-Activating Proteins; Humans; Immunoprecipitation; Leucine; Microscopy, Fluorescence; Mutation; Neurilemmoma; Neurofibromatosis 2; Neurofibromin 2; Phosphatidylinositol 3-Kinases; Point Mutation; Protein Binding; Rats; RNA Interference; Subcellular Fractions; Tetrazolium Salts; Thiazoles; Time Factors | 2004 |
A biosynthetic pathway to isovaleryl-CoA in myxobacteria: the involvement of the mevalonate pathway.
Topics: Acyl Coenzyme A; Animals; Glutarates; Leucine; Methacrylates; Mevalonic Acid; Molecular Structure; Myxococcales; Quinolines; Stigmatella aurantiaca; Thiazoles | 2005 |
Cytotoxic and membrane perturbation effects of a novel amyloid forming model peptide poly(leucine-glutamic acid).
Topics: Adenosine Triphosphatases; Amyloid; Amyloid beta-Peptides; Cell Membrane; Circular Dichroism; Comet Assay; DNA Damage; Dose-Response Relationship, Drug; Free Radicals; Glutamic Acid; Glutathione; Humans; Leucine; Lipid Bilayers; Lymphocytes; Membrane Microdomains; Microscopy, Fluorescence; Oxygen; Peptides; Polyglutamic Acid; Protein Binding; Protein Structure, Secondary; Superoxide Dismutase; Tetrazolium Salts; Thiazoles | 2004 |
Cytotoxic effects of a decoction of Nigella sativa, Hemidesmus indicus and Smilax glabra on human hepatoma HepG2 cells.
Topics: Annexin A5; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; DNA; Flow Cytometry; Hemidesmus; Humans; Leucine; Nigella; Plant Extracts; Seeds; Smilax; Tetrazolium Salts; Thiazoles; Thymidine | 2005 |
Novel 3-amino-2-hydroxy acids containing protease inhibitors. Part 1: Synthesis and kinetic characterization as aminopeptidase P inhibitors.
Topics: Amino Acids; Aminopeptidases; Animals; Binding Sites; Escherichia coli; Kinetics; Leucine; Proline; Protease Inhibitors; Pyrroles; Rats; Structure-Activity Relationship; Substrate Specificity; Thiazoles | 2005 |
Effects of the sequence and size of non-polar residues on self-assembly of amphiphilic peptides.
Topics: Alanine; Amino Acid Motifs; Amyloid; Benzothiazoles; Circular Dichroism; Congo Red; Gene Library; Glycine; Hydrogel, Polyethylene Glycol Dimethacrylate; Isoleucine; Leucine; Macromolecular Substances; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Models, Molecular; Peptides; Phenylalanine; Protein Binding; Protein Conformation; Protein Folding; Protein Structure, Secondary; Temperature; Thiazoles; Ultraviolet Rays; Valine; X-Ray Diffraction | 2005 |
Effect of latanoprost on cultured porcine corneal stromal cells.
Topics: Animals; Benzalkonium Compounds; Calcium; Cell Movement; Cells, Cultured; Collagen Type I; Corneal Stroma; Fibronectins; Fluorescent Antibody Technique; Immunoblotting; Intracellular Membranes; Latanoprost; Leucine; Proline; Prostaglandins F, Synthetic; Staining and Labeling; Swine; Tetrazolium Salts; Thiazoles; Thymidine; Uridine | 2005 |
Halogenation of unactivated carbon centers in natural product biosynthesis: trichlorination of leucine during barbamide biosynthesis.
Topics: Cyanobacteria; Escherichia coli; Hydrocarbons, Chlorinated; Leucine; Thiazoles | 2006 |
Characterization of the initial enzymatic steps of barbamide biosynthesis.
Topics: Cyanobacteria; Genes, Bacterial; Leucine; Molecular Structure; Multigene Family; Peptide Synthases; Polyketide Synthases; Thiazoles | 2006 |
Presence or the emergence of a F317L BCR-ABL mutation may be associated with resistance to dasatinib in Philadelphia chromosome-positive leukemia.
Topics: Adult; Antineoplastic Agents; Blast Crisis; Clinical Trials, Phase II as Topic; Dasatinib; Disease Progression; Drug Resistance, Neoplasm; Female; Genes, abl; Humans; Leucine; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Mutation; Phenylalanine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Thiazoles; Treatment Failure | 2006 |
In vitro and in vivo toxicity of type 2 ribosome-inactivating proteins lanceolin and stenodactylin on glial and neuronal cells.
Topics: Animals; Animals, Newborn; Astrocytes; Cell Survival; Cells, Cultured; Cerebellum; Choline O-Acetyltransferase; Lectins; Leucine; Male; N-Glycosyl Hydrolases; Nerve Tissue Proteins; Neuroglia; Neurons; Passifloraceae; Plant Lectins; Rats; Rats, Wistar; Ribosome Inactivating Proteins, Type 2; Tetrazolium Salts; Thiazoles | 2007 |
Urukthapelstatin A, a novel cytotoxic substance from marine-derived Mechercharimyces asporophorigenens YM11-542. I. Fermentation, isolation and biological activities.
Topics: Antibiotics, Antineoplastic; Cell Line, Tumor; Fermentation; Gram-Positive Endospore-Forming Bacteria; Humans; Leucine; Thiazoles; Water Microbiology | 2007 |
Urukthapelstatin A, a novel cytotoxic substance from marine-derived Mechercharimyces asporophorigenens YM11-542. II. Physico-chemical properties and structural elucidation.
Topics: Antibiotics, Antineoplastic; Crystallography, X-Ray; Gram-Positive Endospore-Forming Bacteria; Leucine; Magnetic Resonance Spectroscopy; Thiazoles; Water Microbiology | 2007 |
Isoflurane preconditioning inhibited isoflurane-induced neurotoxicity.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Administration Schedule; Embryo, Mammalian; Isoflurane; L-Lactate Dehydrogenase; Leucine; Mutation; Neural Inhibition; Neurons; Presenilin-1; Rats; Tetrazolium Salts; Thiazoles; Time Factors; Transfection; Valine | 2007 |
Peroxisome proliferator-activated receptor beta/delta activation improves angiotensin II-induced cardiac hypertrophy in vitro.
Topics: Angiotensin II; Animals; Cardiomegaly; Cell Membrane; Cells, Cultured; Cytokines; Down-Regulation; Fluorescent Antibody Technique; In Vitro Techniques; Leucine; Myocytes, Cardiac; PPAR delta; PPAR-beta; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Staining and Labeling; Thiazoles | 2008 |
BCH, an inhibitor of system L amino acid transporters, induces apoptosis in cancer cells.
Topics: Actins; Amino Acid Transport Systems; Amino Acids, Cyclic; Antineoplastic Agents; Apoptosis; Blotting, Western; Caspases; Cell Division; Cell Line, Tumor; DNA Fragmentation; Enzyme Activation; Humans; In Situ Nick-End Labeling; KB Cells; Large Neutral Amino Acid-Transporter 1; Leucine; Tetrazolium Salts; Thiazoles | 2008 |
Ginsenoside Rg1 attenuates beta-amyloid-induced apoptosis in mutant PS1 M146L cells.
Topics: Amyloid beta-Peptides; Animals; Annexin A5; Apoptosis; Caspase 3; Cell Survival; Central Nervous System Agents; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Flow Cytometry; Ginsenosides; In Situ Nick-End Labeling; Leucine; Methionine; Mutation; Peptide Fragments; Presenilin-1; Tetrazolium Salts; Thiazoles; Transfection | 2008 |
Cytotoxicity effects induced by Zearalenone metabolites, alpha Zearalenol and beta Zearalenol, on cultured Vero cells.
Topics: Animals; Cell Survival; Chlorocebus aethiops; DNA; Estrogens, Non-Steroidal; Heat-Shock Proteins; Leucine; Lipid Peroxidation; Malondialdehyde; Tetrazolium Salts; Thiazoles; Thymidine; Vero Cells; Zearalenone; Zeranol | 2008 |
Evidence for novel beta-sheet structures in Iowa mutant beta-amyloid fibrils.
Topics: Amyloid; Amyloid beta-Peptides; Amyloid Neuropathies, Familial; Aspartic Acid; Benzothiazoles; Glutamic Acid; Humans; Kinetics; Leucine; Lysine; Microscopy, Electron, Transmission; Models, Molecular; Mutation, Missense; Nuclear Magnetic Resonance, Biomolecular; Peptide Fragments; Phenylalanine; Protein Structure, Secondary; Spectrometry, Fluorescence; Thiazoles; X-Ray Diffraction | 2009 |
Major molecular response achieved with dasatinib in a CML patient with F317L BCR-ABL kinase domain mutation.
Topics: Amino Acid Substitution; Antineoplastic Agents; Cytogenetic Analysis; Dasatinib; Drug Resistance, Neoplasm; Humans; Leucine; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Phenylalanine; Protein Structure, Tertiary; Proto-Oncogene Proteins c-bcr; Pyrimidines; Thiazoles; Treatment Outcome | 2010 |
Discovery of a potent and selective noncovalent linear inhibitor of the hepatitis C virus NS3 protease (BI 201335).
Topics: Aminoisobutyric Acids; Animals; Antiviral Agents; Hepacivirus; Humans; Leucine; Male; Microsomes, Liver; Oligopeptides; Proline; Quinolines; Rats; Rats, Sprague-Dawley; Replicon; Serine Proteinase Inhibitors; Structure-Activity Relationship; Thiazoles; Viral Nonstructural Proteins | 2010 |
Preclinical characterization of BI 201335, a C-terminal carboxylic acid inhibitor of the hepatitis C virus NS3-NS4A protease.
Topics: Aminoisobutyric Acids; Animals; Antiviral Agents; Caco-2 Cells; Carrier Proteins; Cell Line, Tumor; Hepacivirus; Humans; Intracellular Signaling Peptides and Proteins; Leucine; Male; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Rats; Thiazoles; Viral Nonstructural Proteins; Viral Proteins; Virus Replication | 2010 |
Combined X-ray, NMR, and kinetic analyses reveal uncommon binding characteristics of the hepatitis C virus NS3-NS4A protease inhibitor BI 201335.
Topics: Aminoisobutyric Acids; Carrier Proteins; Catalytic Domain; Clinical Trials, Phase I as Topic; Crystallography, X-Ray; Hepacivirus; Hepatitis C; Humans; Intracellular Signaling Peptides and Proteins; Leucine; Nuclear Magnetic Resonance, Biomolecular; Oligopeptides; Proline; Protease Inhibitors; Protein Binding; Quinolines; Thiazoles; Viral Nonstructural Proteins | 2011 |
Durable molecular response despite F317L and E255K mutations: Successful treatment of chronic myeloid leukemia with sequential imatinib, nilotinib and dasatinib.
Topics: Adult; Amino Acid Substitution; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Biomarkers, Pharmacological; Biomarkers, Tumor; Dasatinib; Female; Fusion Proteins, bcr-abl; Glutamic Acid; Humans; Imatinib Mesylate; Leucine; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lysine; Mutation, Missense; Phenylalanine; Piperazines; Polymorphism, Single Nucleotide; Pyrimidines; Remission Induction; Thiazoles; Time Factors; Treatment Outcome | 2012 |
Cross-species absorption, metabolism, distribution and pharmacokinetics of BI 201335, a potent HCV genotype 1 NS3/4A protease inhibitor.
Topics: Absorption; Aminoisobutyric Acids; Animals; Antiviral Agents; Biological Availability; Caco-2 Cells; Dogs; Drug Evaluation, Preclinical; Hepacivirus; Humans; Leucine; Macaca mulatta; Male; Microsomes, Liver; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Rats; Rats, Sprague-Dawley; Thiazoles; Tissue Distribution; Viral Nonstructural Proteins | 2012 |
In vitro resistance profile of the hepatitis C virus NS3 protease inhibitor BI 201335.
Topics: Amino Acid Substitution; Aminoisobutyric Acids; Antiviral Agents; Crystallography, X-Ray; Drug Resistance, Viral; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Inhibitory Concentration 50; Interferon-alpha; Kinetics; Leucine; Mutagenesis, Site-Directed; Mutation Rate; Oligopeptides; Phenotype; Proline; Protease Inhibitors; Quinolines; Replicon; Thiazoles; Viral Nonstructural Proteins | 2012 |
Interferon-free treatment regimens for hepatitis C: are we there yet?
Topics: Aminoisobutyric Acids; Antiviral Agents; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Leucine; Male; Oligopeptides; Proline; Quinolines; Ribavirin; RNA-Dependent RNA Polymerase; Thiazoles | 2011 |
Nampt secreted from cardiomyocytes promotes development of cardiac hypertrophy and adverse ventricular remodeling.
Topics: Animals; Animals, Newborn; Cardiomegaly; Coloring Agents; Echocardiography; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Fibrosis; Immunohistochemistry; Leucine; Mice; Mice, Knockout; Mice, Transgenic; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; NFATC Transcription Factors; Nicotinamide Phosphoribosyltransferase; Rats; Real-Time Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tetrazolium Salts; Thiazoles; Ventricular Remodeling | 2013 |
Solid phase versus solution phase synthesis of heterocyclic macrocycles.
Topics: Cyclization; Cysteine; Leucine; Oxidation-Reduction; Peptides, Cyclic; Serine; Solid-Phase Synthesis Techniques; Solutions; Thiazoles | 2013 |
Total synthesis and biological activity of natural product Urukthapelstatin A.
Topics: Biological Products; Inhibitory Concentration 50; Leucine; Molecular Structure; Serine; Stereoisomerism; Thiazoles | 2013 |
Baseline hepatitis C virus (HCV) NS3 polymorphisms and their impact on treatment response in clinical studies of the HCV NS3 protease inhibitor faldaprevir.
Topics: Amino Acid Substitution; Aminoisobutyric Acids; Antiviral Agents; Clinical Trials as Topic; Drug Monitoring; Drug Resistance, Viral; Gene Expression; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Leucine; Mutation; Oligopeptides; Polymorphism, Genetic; Proline; Protease Inhibitors; Quinolines; Thiazoles; Viral Nonstructural Proteins | 2014 |
Enzyme-transporter interplay in the formation and clearance of abundant metabolites of faldaprevir found in excreta but not in circulation.
Topics: Aminoisobutyric Acids; Antiviral Agents; ATP-Binding Cassette Transporters; Caco-2 Cells; Cell Membrane Permeability; Cytochrome P-450 Enzyme System; Drug Stability; Drug Storage; Feces; Female; Hepatocytes; Humans; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Intestines; Kinetics; Leucine; Male; Metabolic Clearance Rate; Microsomes; Oligopeptides; Proline; Protein Binding; Quinolines; Thiazoles | 2014 |
Bridging in vitro and in vivo metabolism and transport of faldaprevir in human using a novel cocultured human hepatocyte system, HepatoPac.
Topics: Aminoisobutyric Acids; Antiviral Agents; Biological Transport; Biotransformation; Cells, Cultured; Coculture Techniques; Cryopreservation; Culture Media; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Drug Stability; Female; Fibroblasts; Glucuronides; Hepatocytes; Humans; Kinetics; Leucine; Liver; Liver-Specific Organic Anion Transporter 1; Metabolic Clearance Rate; Molecular Structure; Oligopeptides; Organic Anion Transporters; Proline; Quinolines; Sodium; Thiazoles | 2014 |
Generating an in vitro-in vivo correlation for metabolism and liver enrichment of a hepatitis C virus drug, faldaprevir, using a rat hepatocyte model (HepatoPac).
Topics: Aminoisobutyric Acids; Animals; Antiviral Agents; Bile; Biological Transport; Biotransformation; Cells, Cultured; Coculture Techniques; Cryopreservation; Culture Media; Dose-Response Relationship, Drug; Drug Stability; Fibroblasts; Glucuronides; Hepacivirus; Hepatocytes; Leucine; Liver; Male; Metabolic Clearance Rate; Molecular Structure; Oligopeptides; Proline; Quinolines; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Thiazoles | 2014 |
Minimum costs for producing hepatitis C direct-acting antivirals for use in large-scale treatment access programs in developing countries.
Topics: Aminoisobutyric Acids; Anti-HIV Agents; Antiviral Agents; Carbamates; Developing Countries; Drug Industry; Drug Therapy, Combination; Health Services Accessibility; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 3-Ring; Humans; Imidazoles; Leucine; Oligopeptides; Proline; Pyrrolidines; Quinolines; Ribavirin; Simeprevir; Sofosbuvir; Sulfonamides; Thiazoles; Uridine Monophosphate; Valine | 2014 |
Oxicams bind in a novel mode to the cyclooxygenase active site via a two-water-mediated H-bonding Network.
Topics: Amino Acid Substitution; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Binding Sites; Catalytic Domain; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Hydrogen Bonding; Leucine; Meloxicam; Mice; Mutation; Piroxicam; Protein Structure, Secondary; Serine; Thiazines; Thiazoles; Tyrosine; Water | 2014 |
Review article: 2014 UK consensus guidelines - hepatitis C management and direct-acting anti-viral therapy.
Topics: Aminoisobutyric Acids; Antiviral Agents; Drug Therapy, Combination; Hepatitis C, Chronic; Heterocyclic Compounds, 3-Ring; Humans; Interferon-alpha; Interferons; Leucine; Oligopeptides; Proline; Quinolines; Ribavirin; Simeprevir; Sofosbuvir; Sulfonamides; Thiazoles; Uridine Monophosphate | 2014 |
Biotransformation and mass balance of faldaprevir, a hepatitis C NS3/NS4 protease inhibitor in rats.
Topics: Administration, Oral; Aminoisobutyric Acids; Animals; Bile; Biotransformation; Carbon Radioisotopes; Feces; Female; Injections, Intravenous; Leucine; Male; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Thiazoles; Urine | 2014 |
Protease inhibitors to treat hepatitis C in the Swiss HIV Cohort Study: high efficacy but low treatment uptake.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Cohort Studies; Female; Hepatitis C, Chronic; HIV Infections; Humans; Leucine; Male; Middle Aged; Oligopeptides; Patient Acceptance of Health Care; Proline; Prospective Studies; Protease Inhibitors; Quinolines; RNA, Viral; Switzerland; Thiazoles; Viral Load | 2015 |
Structure Elucidation of Poly-Faldaprevir: Polymer Backbone Solved Using Solid-State and Solution Nuclear Magnetic Resonance Spectroscopy.
Topics: Aminoisobutyric Acids; Leucine; Magnetic Resonance Spectroscopy; Molecular Structure; Oligopeptides; Polymers; Proline; Quinolines; Spectrometry, Mass, Electrospray Ionization; Thiazoles | 2016 |
Resistance Analyses of HCV NS3/4A Protease and NS5B Polymerase from Clinical Studies of Deleobuvir and Faldaprevir.
Topics: Acrylates; Amino Acid Substitution; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Carrier Proteins; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Drug Resistance, Viral; Hepacivirus; Hepatitis C, Chronic; Humans; Intracellular Signaling Peptides and Proteins; Leucine; Mutation; Oligopeptides; Polymorphism, Genetic; Proline; Protease Inhibitors; Quinolines; Thiazoles; Treatment Outcome; Viral Nonstructural Proteins | 2016 |
Effect of D168V mutation in NS3/4A HCV protease on susceptibilities of faldaprevir and danoprevir.
Topics: Amino Acid Substitution; Aminoisobutyric Acids; Binding Sites; Catalytic Domain; Codon; Cyclopropanes; Drug Resistance, Viral; Hepacivirus; Humans; Hydrogen Bonding; Isoindoles; Lactams; Lactams, Macrocyclic; Leucine; Models, Molecular; Molecular Conformation; Mutation; Oligopeptides; Proline; Protein Binding; Quinolines; Sulfonamides; Thiazoles; Viral Nonstructural Proteins | 2016 |
[Molecular recognition mechanism and motion of HCV NS3/4A protease with Faldaprevir analogue].
Topics: Aminoisobutyric Acids; Antiviral Agents; Carrier Proteins; Drug Resistance, Viral; Endopeptidases; Hepacivirus; Intracellular Signaling Peptides and Proteins; Leucine; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Oligopeptides; Proline; Protease Inhibitors; Quinolines; Serine Proteases; Thiazoles; Viral Nonstructural Proteins | 2016 |
Hemocompatible LAT1-inhibitor can induce apoptosis in cancer cells without affecting brain amino acid homeostasis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzoxazoles; Brain; Brain Chemistry; Carboxylic Acids; Drug Synergism; Gene Expression Regulation, Neoplastic; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Injections, Intraperitoneal; Large Neutral Amino Acid-Transporter 1; Leucine; Male; MCF-7 Cells; Mice; Myocytes, Smooth Muscle; NF-kappa B; Norbornanes; Primary Cell Culture; Pyridines; Signal Transduction; Thiazoles; TOR Serine-Threonine Kinases; Tyrosine | 2020 |
Effect of itraconazole on the pharmacokinetics of faldaprevir in healthy subjects.
Topics: Adult; Aminoisobutyric Acids; Drug Interactions; Female; Healthy Volunteers; Humans; Itraconazole; Leucine; Male; Middle Aged; Proline; Quinolines; Thiazoles | 2021 |