Compounds > thiazoles
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thiazoles and leflunomide

thiazoles has been researched along with leflunomide in 10 studies

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (10.00)18.2507
2000's6 (60.00)29.6817
2010's2 (20.00)24.3611
2020's1 (10.00)2.80

Authors

AuthorsStudies
Ballaron, SJ; Byars, N; Cherwinski, HM; Nakano, GM; Ransom, JT; Young, JM1
Miljkovic, D; Mostarica Stojkovic, M; Popadic, D; Samardzic, T; Stosic-Grujicic, S; Trajkovic, V1
Drakulic, D; Miljkovic, Dj; Samardzic, T; Stosic-Grujicic, S; Trajkovic, V1
Feng, H; Gao, JW; Li, XY; Tang, MY; Xu, LF; Zheng, JR1
Hashkes, PJ; Laxer, RM1
Bian, F; Hao, N; Zhang, M1
Díaz, J; González, A; Mora, C; Quintana, G1
Chernyak, BV; Chumakov, PM; Evstafieva, AG; Khutornenko, AA; Roudko, VV; Vartapetian, AB1
Bussink, J; Grénman, R; Iida, M; Kaanders, JH; Peeters, WJ; Span, PN; Stegeman, H; van der Kogel, AJ; Verheijen, MM; Wheeler, DL1
Chen, Y; Ding, M; Jiang, X; Lan, K; Lavillete, D; Li, H; Li, S; Liu, Y; Shan, J; Shang, W; Shen, Z; Sun, Y; Tong, Y; Wang, R; Wang, Y; Wu, Y; Xiao, G; Xiong, R; Xu, K; Xu, L; Zhang, L; Zhao, Y; Zhao, Z; Zhu, L; Zou, G1

Reviews

1 review(s) available for thiazoles and leflunomide

ArticleYear
Update on the medical treatment of juvenile idiopathic arthritis.
    Current rheumatology reports, 2006, Volume: 8, Issue:6

    Topics: Antibodies, Blocking; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Juvenile; Child; Child, Preschool; Humans; Immunologic Factors; Infliximab; Isoxazoles; Leflunomide; Meloxicam; Methotrexate; Naproxen; Rheumatology; Thiazines; Thiazoles

2006

Other Studies

9 other study(ies) available for thiazoles and leflunomide

ArticleYear
Leflunomide interferes with pyrimidine nucleotide biosynthesis.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1995, Volume: 44, Issue:8

    Topics: Animals; Concanavalin A; Female; Humans; Immunosuppressive Agents; In Vitro Techniques; Indicators and Reagents; Isoxazoles; Leflunomide; Mice; Mice, Inbred BALB C; PC12 Cells; Pyrimidine Nucleotides; Rats; Spleen; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured

1995
Leflunomide inhibits activation of inducible nitric oxide synthase in rat astrocytes.
    Brain research, 2001, Jan-19, Volume: 889, Issue:1-2

    Topics: Animals; Astrocytes; Astrocytoma; Cell Line; Enzyme Activation; Immunosuppressive Agents; Indicators and Reagents; Interferon-gamma; Isoxazoles; Leflunomide; Lipopolysaccharides; Mitogen-Activated Protein Kinase Kinases; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Protein-Tyrosine Kinases; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazolium Salts; Thiazoles

2001
Immunosuppressants leflunomide and mycophenolic acid inhibit fibroblast IL-6 production by distinct mechanisms.
    Cytokine, 2002, Aug-21, Volume: 19, Issue:4

    Topics: Aniline Compounds; Animals; Cell Line; Cell Survival; Cells, Cultured; Coloring Agents; Crotonates; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Guanidines; Humans; Hydroxybutyrates; Immunosuppressive Agents; Interferon-gamma; Interleukin-6; Isoxazoles; Leflunomide; Macrophages; Mice; Mycophenolic Acid; Nitric Oxide Synthase; Nitriles; omega-N-Methylarginine; Phosphodiesterase Inhibitors; Rolipram; Tetrazolium Salts; Thiazoles; Time Factors; Toluidines

2002
Inhibition of the nuclear factor-kappaB signaling pathway by leflunomide or triptolide also inhibits the anthralin-induced inflammatory response but does not affect keratinocyte growth inhibition.
    Biological & pharmaceutical bulletin, 2005, Volume: 28, Issue:9

    Topics: Anthralin; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Cell Proliferation; Cells, Cultured; Diterpenes; Enzyme Inhibitors; Epoxy Compounds; Humans; I-kappa B Proteins; Immunosuppressive Agents; Intercellular Adhesion Molecule-1; Interleukin-8; Isoxazoles; Keratinocytes; Leflunomide; NF-kappa B; Phenanthrenes; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tetrazolium Salts; Thiazoles

2005
The active metabolite of leflunomide A771726 inhibits corneal neovascularization.
    Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2008, Volume: 28, Issue:3

    Topics: Aniline Compounds; Animals; Cell Nucleus; Cell Proliferation; Corneal Neovascularization; Crotonates; Disease Models, Animal; Humans; Hydrogen-Ion Concentration; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Nitriles; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; Tetrazolium Salts; Thiazoles; Time Factors; Toluidines; Umbilical Veins

2008
[Financial cost of early rheumatoid arthritis in the first year of medical attention: three clinical scenarios in a third-tier university hospital in Colombia].
    Biomedica : revista del Instituto Nacional de Salud, 2009, Volume: 29, Issue:1

    Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Protocols; Colombia; Diagnostic Services; Direct Service Costs; Disease Management; Drug Costs; Drug Therapy, Combination; Etanercept; Health Care Costs; Hospital Costs; Hospitals, University; Humans; Hydroxychloroquine; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Meloxicam; Methotrexate; Receptors, Tumor Necrosis Factor; Sulfasalazine; Thiazines; Thiazoles

2009
Pyrimidine biosynthesis links mitochondrial respiration to the p53 pathway.
    Proceedings of the National Academy of Sciences of the United States of America, 2010, Jul-20, Volume: 107, Issue:29

    Topics: Apoptosis; Cell Line, Tumor; Cell Respiration; Dihydroorotate Dehydrogenase; Electron Transport Complex III; Humans; Isoxazoles; Leflunomide; Membrane Potential, Mitochondrial; Methacrylates; Mitochondria; NAD(P)H Dehydrogenase (Quinone); Oxidoreductases Acting on CH-CH Group Donors; Potassium Cyanide; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Pyrimidines; Quinone Reductases; Reactive Oxygen Species; Signal Transduction; Thiazoles; Tumor Suppressor Protein p53; Up-Regulation

2010
Combining radiotherapy with MEK1/2, STAT5 or STAT6 inhibition reduces survival of head and neck cancer lines.
    Molecular cancer, 2013, Nov-05, Volume: 12, Issue:1

    Topics: Antineoplastic Agents; Butadienes; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; Chemoradiotherapy; Dasatinib; Drug Screening Assays, Antitumor; Head and Neck Neoplasms; Humans; Imidazoles; Isoxazoles; Leflunomide; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Nitriles; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Radiation Tolerance; STAT5 Transcription Factor; STAT6 Transcription Factor; Thiazoles; Tumor Suppressor Proteins

2013
Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2.
    Protein & cell, 2020, Volume: 11, Issue:10

    Topics: Animals; Antiviral Agents; Betacoronavirus; Binding Sites; Cell Line; Coronavirus Infections; COVID-19; Crotonates; Cytokine Release Syndrome; Dihydroorotate Dehydrogenase; Drug Evaluation, Preclinical; Gene Knockout Techniques; Humans; Hydroxybutyrates; Influenza A virus; Leflunomide; Mice; Mice, Inbred BALB C; Nitriles; Orthomyxoviridae Infections; Oseltamivir; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pandemics; Pneumonia, Viral; Protein Binding; Pyrimidines; RNA Viruses; SARS-CoV-2; Structure-Activity Relationship; Thiazoles; Toluidines; Ubiquinone; Virus Replication

2020