Compounds > thiazoles
Page last updated: 2024-08-21

thiazoles and kni-727

thiazoles has been researched along with kni-727 in 4 studies

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Goto, T; Hamawaki, T; Hayashi, Y; Kimura, T; Kiso, Y; Kumagai, A; Matsumoto, H; Sano, K1
Freire, E; Kimura, T; Kiso, Y; Luque, I; Nezami, A1
Hayashi, Y; Ito, T; Kimura, T; Kiso, Y; Matsumoto, H; Sohma, Y1
Hamada, Y; Hayashi, Y; Kimura, T; Kiso, Y; Matsumoto, H; Yamaguchi, S1

Other Studies

4 other study(ies) available for thiazoles and kni-727

ArticleYear
Design, synthesis, and biological evaluation of anti-HIV double-drugs. conjugates of HIV protease inhibitors with a reverse transcriptase inhibitor through spontaneously cleavable linkers.
    Bioorganic & medicinal chemistry, 2001, Volume: 9, Issue:6

    Topics: Animals; Anti-HIV Agents; Drug Design; Drug Evaluation, Preclinical; HIV Protease Inhibitors; Humans; Prodrugs; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Thiazoles; Tumor Cells, Cultured; Zidovudine

2001
Identification and characterization of allophenylnorstatine-based inhibitors of plasmepsin II, an antimalarial target.
    Biochemistry, 2002, Feb-19, Volume: 41, Issue:7

    Topics: Amides; Animals; Antimalarials; Aspartic Acid Endopeptidases; Binding Sites; Chromogenic Compounds; Enzyme Stability; Erythrocytes; Humans; Models, Molecular; Phenylbutyrates; Plasmodium falciparum; Protease Inhibitors; Protozoan Proteins; Substrate Specificity; Thermodynamics; Thiazoles

2002
Development of water-soluble prodrugs of the HIV-1 protease inhibitor KNI-727: importance of the conversion time for higher gastrointestinal absorption of prodrugs based on spontaneous chemical cleavage.
    Journal of medicinal chemistry, 2003, Sep-11, Volume: 46, Issue:19

    Topics: Animals; Area Under Curve; Biological Availability; Carbamates; Cyclization; Drug Design; Duodenum; Furans; Half-Life; HIV Protease Inhibitors; Imides; Intestinal Absorption; Male; Organophosphates; Prodrugs; Rats; Rats, Sprague-Dawley; Solubility; Structure-Activity Relationship; Sulfonamides; Thiazoles; Water

2003
Water-soluble prodrugs of dipeptide HIV protease inhibitors based on O-->N intramolecular acyl migration: Design, synthesis and kinetic study.
    Bioorganic & medicinal chemistry, 2004, Jan-02, Volume: 12, Issue:1

    Topics: Acylation; Dipeptides; Drug Design; HIV Protease Inhibitors; Humans; Kinetics; Prodrugs; Solubility; Thiazoles; Water

2004