thiazoles has been researched along with indomethacin in 177 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 36 (20.34) | 18.7374 |
| 1990's | 55 (31.07) | 18.2507 |
| 2000's | 68 (38.42) | 29.6817 |
| 2010's | 15 (8.47) | 24.3611 |
| 2020's | 3 (1.69) | 2.80 |
| Authors | Studies |
|---|---|
| Ohtsuki, H; Okabe, S; Tabata, K | 1 |
| Droller, MJ; Perlmann, P; Schneider, MU | 1 |
| Aikawa, T; Goto, M; Oishi, T; Suzuki, T; Takano, S; Tamura, O | 1 |
| Levy, JV | 1 |
| De Luca, G; Materazzi, M; Palamara, G | 1 |
| Dove, PA; Rosenthale, ME; Sandor, A; Shriver, DA; White, CB | 1 |
| Davies, JE; Kellett, DN; Pennington, JC | 1 |
| Fatimi, J; Lagorce, JF; Lakhdar, M; Nefaoui, S; Raby, C | 1 |
| Adler, KB; Akley, NJ; Glasgow, WC | 1 |
| Asano, M; Hamada, K; Inamura, N; Isono, T; Kohsaka, M; Nagayoshi, A; Nakahara, K; Notsu, Y; Oku, T; Ono, T | 1 |
| Goddard, CJ; Hakkinen, JP; Holt, WF; Maciejko, JJ; Murphy, WR; Oates, PJ; Reiter, LA | 1 |
| Imanishi, N; Morooka, S; Sugasawa, T; Uchida, M | 1 |
| Bruno, M; Grassi, A; Ippen, J; Thomas, G | 1 |
| Bonne, C; Meynier, F; Muller, A | 1 |
| Cass, WA; Dunwiddie, TV; Fitzpatrick, FA; Taylor, M; Zahniser, NR | 1 |
| Nebel, U; Wermelskirchen, D; Wilffert, B; Wirth, A | 1 |
| Bertrand, C; Landry, Y; Tschirhart, E | 1 |
| Bast, A; Leurs, R; Timmerman, H | 1 |
| Bonne, C; Coquelet, C; Latour, E; Tissié, G; Trong, HN | 1 |
| Bodin, C; Bonne, C; Chastel, C; Colin, J; Jouppe, B; Malet, F | 1 |
| Huang, TF; Hung, ML; Ouyang, C; Teng, CM | 1 |
| Dale, MM; Penfield, A | 1 |
| Dale, MM; Muid, RE; Twomey, B | 1 |
| Hayashi, M; Oh, S; Yamaki, K | 1 |
| Krüger, S; Schlegel, W | 1 |
| Knee, CD; Krell, RD; Kusner, EJ | 1 |
| Genovese, A; Levi, R; Robertson, DA | 1 |
| Handley, DA; Saunders, RN; Van Valen, RG | 1 |
| Fukuda, S; Hotta, T; Itoh, H; Kawasaki, T; Komatsu, K; Kuwayama, H; Matsuo, Y; Ohsaka, Y; Seki, A | 1 |
| Alloatti, G; Camussi, G; Emanuelli, G; Montrucchio, G; Roffinello, C; Tetta, C | 1 |
| Kogo, H; Matsudaira, T; Satoh, T | 1 |
| Shukla, SD | 1 |
| Alburn, HE; Dougherty, JA; Fenichel, RL | 1 |
| Brown, K; Cater, DP; Cavalla, JF; Green, D; Newberry, RA; Wilson, AB | 1 |
| Chester, R; Dukes, M; Slater, SR; Walpole, AL | 1 |
| Brown, K; Cavalla, JF; Green, D; Wilson, AB | 1 |
| Abe, Y; Imanishi, M; Komori, T; Miura, K; Okahara, T; Yamamoto, K; Yukimura, T | 1 |
| Inglot, AD | 1 |
| Sakurai, K; Suzuki, T; Takano, S | 1 |
| Famaey, JP; Gaci, O; Ginsberg, F | 1 |
| Blaine, EH | 1 |
| Bogulska, M; Katzenellenbogen, E; Lugowski, C; Romanowska, E | 1 |
| Bex, FJ; Corbin, A | 1 |
| Inglot, AD; Wolna, E | 1 |
| Davis, BB; Mattammal, MB; Zenser, TV | 2 |
| Aizawa, Y; Hasegawa, N; Inazu, N; Kogo, H; Takeuchi, K; Yamada, K; Yoshida, Y | 1 |
| Dodge, GR; Rappaport, RS | 1 |
| Obata, Y; Oda, M; Yamamoto, N; Yokota, K | 2 |
| Oda, M; Yamashita, A; Yokota, K | 1 |
| Batt, DG; Corbett, RL; Di Meo, SV; Freimark, B; Giannaras, JV; Orwat, MJ; Petraitis, JJ; Pinto, DJ; Pratta, MA; Wright, SW | 1 |
| Geronikaki, A; Kourounakis, PN; Mgonzo, R | 1 |
| Leduc, D; Pretolani, M; Vargaftig, BB; Zuany-Amorim, C | 1 |
| Khair-el-Din, TA; Lu, CY; Sicher, SC; Vazquez, MA; Wright, WJ | 1 |
| Devissaguet, M; Ferreira, SH; Lesieur, D; Lorenzetti, BB; Tsouderos, Y | 1 |
| Inoue, Y; Ishikawa, H; Katsura, Y; Takasugi, H; Tomishi, T | 1 |
| Ishizaka, M; Nishihata, T; Yamamoto, K | 1 |
| Fang, GD; Fonteles, MC; Guerrant, RL; Thielman, NM | 1 |
| Kashiwazaki, S; Koga, Y; Nakamura, K; Nishikaku, F | 1 |
| Audus, KL; Shah, PK; Zheng, H | 1 |
| Benabe, JE; Martínez-Maldonado, M; Pedraza-Chaverri, J | 1 |
| Horiba, M; Kohno, S; Nabe, T; Ohata, K; Tsuzuike, N; Yamamura, H | 1 |
| Oda, M; Yamamoto, N; Yamashita, A; Yokota, K | 1 |
| Frölich, JC; Stichtenoth, DO; Wagner, B | 2 |
| Fox, SM; Johnston, SA | 1 |
| Fujimura, S; Kobayashi, S; Okada, S; Yoshida, H | 1 |
| Agut, J; Conejo, L; Márquez, M; Ortiz, JA; Palop, D; Sacristán, A | 1 |
| Conejo, L; Ortiz, JA; Palop, D; Romero, A; Sacristán, A; Villamayor, F | 1 |
| Coltau, M; Fillat, O; Herrero, E; Márquez, M; Ortiz, JA; Puscas, C; Puscas, I; Torres, J | 1 |
| Piotrowski, J; Slomiany, A; Slomiany, BL | 2 |
| Blanque, R; Cottereaux, C; Gardner, CR | 1 |
| Harada, Y; Hatanaka, K; Katori, M; Kawamura, M; Ogino, K | 1 |
| Rainsford, KD; Smith, FC; Ying, C | 1 |
| Laird, JM; Lopez-Garcia, JA | 1 |
| Gimble, JM; Kelly, KA | 1 |
| Thulesius, O; Yousif, MH | 1 |
| Chang, MS; Choi, WS; Chung, YK; Kim, KB; Kim, SG; Sohn, SK; Wook, TW | 1 |
| Fujimura, S; Hasumi, T; Kobayashi, S; Okada, S; Sato, N | 1 |
| Chindemi, P; Delaney, K; Rainsford, KD; Skerry, TM | 1 |
| Addya, S; Boden, G; Murer, E; Sinha, D | 1 |
| Amicosante, G; Barracchini, A; Di Giulio, AD; Franceschini, N; Minisola, G; Oratore, A; Pantaleoni, GC | 1 |
| Combs, CK; Doller, C; Fitch, MT; Landreth, GE; Silver, J | 1 |
| Case, J; Davison, CA | 1 |
| Chang, MS; Choi, WS; Chung, YK; Kim, KB; Lee, SB; Sohn, SK; Woo, TW | 1 |
| de Meijer, A; de Metz, M; Novakova, I; Thomas, C; Verbruggen, B; Vollaard, H | 1 |
| Hu, D; Syriatowicz, JP; Tracey, DJ; Walker, JS | 1 |
| Brzozowski, T; Drozdowicz, D; Hahn, EG; Konturek, PC; Konturek, SJ; Pajdo, R; Sliwowski, Z; Stachura, J | 1 |
| Wallace, JL | 1 |
| Mitchell, JA; Pepper, JR; Stanford, SJ | 1 |
| Goto, T; Motoyama, Y; Ochi, T | 1 |
| Arroyo, MT; Lanas, A; Sáinz, R | 1 |
| Hashiramoto, A; Kohno, M; Kondo, M; Kusaka, Y; Sano, H; Tsubouchi, Y; Yamada, R | 1 |
| Tavares, IA | 1 |
| Hisatome, I; Ogino, K; Shigemasa, C; Shimoyama, M; Uchida, K | 1 |
| Alencar, VB; Bezerra, MM; Brito, GA; de Lima, V; Ribeiro, RA; Rocha, FA; Vieira, IB | 1 |
| Arakida, Y; Morio, H; Ohga, K; Okada, Y; Suwa, K; Yamada, T; Yokota, M | 1 |
| Bouvier, M; Girod, V; Grélot, L | 1 |
| Bäumer, W; Kietzmann, M | 1 |
| Brzozowski, T; Drozdowicz, D; Hahn, EG; Konturek, PC; Konturek, SJ; Pajdo, R; Ptak, A; Sliwowski, Z | 1 |
| Bell, RL; Hulkower, KI; McCroskey, RW; Michaelides, MR; Wada, CK; Woods, KW | 1 |
| Harada, K; Inoue, T; Nagakura, N; Oketani, K | 1 |
| Sadowski, T; Steinmeyer, J | 2 |
| Bláha, L; Hofmanová, J; Kozubík, A; Minksová, K; Soucek, K; Stika, J; Vondrácek, J | 1 |
| Bai, JC; Mauriño, E; Meddings, J; Niveloni, S; Pedreira, S; Smecuol, E; Sugai, E; Vazquez, H | 1 |
| Amro, BI; Gharaibeh, MN; Salhab, AS; Shomaf, MS | 1 |
| Levine, L | 1 |
| Akiguchi, I; Kawasaki, T; Miyake, S; Miyamoto, K; Oka, N; Yamamura, T | 1 |
| Bouvier, M; Dapzol, J; Girod, V; Grélot, L | 1 |
| Bagirova, VV; Krasikov, SI; Mitrofanova, OV | 1 |
| Gagnier, RP; Rinder, HM; Souhrada, M; Tracey, JB; Wang, C; Wood, CC | 1 |
| Georganas, C; Kosmaoglou, EV; Papatsoris, AG; Pardalidis, NP | 1 |
| Corbett, L; Knox, AJ; Nie, M; Pang, L | 1 |
| Barthel, T; Baumann, B; Eulert, J; Nöth, U | 1 |
| Cheng, GF; Guo, Y; Hu, YF | 1 |
| Gu, Y; Lin, S; Ma, J; Yang, H; Zuo, Y | 1 |
| Bösch, P; Legenstein, R; Ungersböck, A | 1 |
| Faletti, AG; Farina, M; Lomniczi, A; Mohn, C; Rettori, V | 1 |
| Inoue, N; Matsui, M; Tachibana, M; Ukai, Y; Yano, J; Yoshida, E | 1 |
| Gao, F; Hirata, K; Horie, T; Sosogi, A; Tomimatsu, T | 1 |
| Bennett, PR; Sawdy, RJ; Sullivan, MH | 1 |
| Bennett, P; Pan, H; Sawdy, R; Sullivan, M | 1 |
| Chung, JY; Jung, BK; Kim, A; Kim, KR; Kim, SR; Lee, PR; Won, HS | 1 |
| Bishop-Bailey, D; Warner, TD | 1 |
| Morikawa, K; Morikawa, S; Nakano, A; Torii, I | 1 |
| Bahekar, RH; Bhusari, KP; Chopade, RS; Khedekar, PB; Rao, AR; Umathe, SN | 1 |
| Dirksen, R; Durieux, ME; Slappendel, R; Spruit, M; van der Heide, H; Weber, EW | 1 |
| Alfaidy, N; Challis, JR; Martin, R; Mirazi, N | 1 |
| Bugajski, AJ; Bugajski, J; Gadek-Michalska, A; Głód, R; Thor, P | 1 |
| Chichorro, JG; Lorenzetti, BB; Zampronio, AR | 1 |
| Cella, M; Farina, M; Franchi, A; Ribeiro, M | 1 |
| Abe, M; Iida, H; Inoue, S; Okabe, S; Tanaka, J; Yuda, Y | 1 |
| Klooster, N; Slappendel, R; Spruit, M; van der Heide, HJ; van Limbeek, J | 1 |
| Engberg, G; Erhardt, C; Erhardt, S; Schwieler, L | 1 |
| Atlihan, E; Buduneli, N; Cetin, EO; Kirilmaz, L | 1 |
| Caicedo, E; Choo, DI; Harris, G; Jhanjee, R; Juhn, SK; Ondrey, F; Preciado, D; Silver, R | 1 |
| Bai, JY; Cheng, GF; Yin, H | 1 |
| Bishop-Bailey, D; Mitchell, JA; Vojnovic, I; Warner, TD | 1 |
| Chiu, LC; Ooi, VE; Tong, KF | 1 |
| Edwards, RM; Evans, C; Hieble, JP; McCafferty, GP; Wibberley, A | 1 |
| Castro, RR; Cunha, FQ; Rocha, FA; Silva, FS | 1 |
| Hamazaki, T; Kogure, S; Naoi, K; Saito, M; Watanabe, S | 1 |
| Joseph-Ridge, N; Khosravan, R; Vernillet, L; Wu, JT | 1 |
| Hane, M; Hara, S; Naito, Y; Narita, T; Okabe, N; Tani, K; Yamamoto, Y | 1 |
| Granado, M; López-Calderón, A; Martín, AI; Villanúa, MA | 1 |
| Boursinos, L; Karachalios, T; Khaldi, L; Malizos, KN; Poultsides, L | 1 |
| d'Uscio, LV; He, T; Katusic, ZS; Lam, CF; Lee, HC; Lu, T | 1 |
| Biscetti, F; Pola, R | 1 |
| Chakraborty, H; Mondal, S; Sarkar, M | 1 |
| Babis, GC; Korres, DS; Nikolopoulos, K; Soucacos, PN; Tsailas, PG | 1 |
| Kalgutkar, AS; Obach, RS; Soglia, JR; Zhao, SX | 1 |
| Hara, A; Hirose, Y; Hoshino, T; Murashita, H; Tabuchi, K; Tobita, T; Uemaetomari, I | 1 |
| Au, AL; Chan, SW; Kwan, YW; Lee, SM; Leung, GP; Li, RW; Seto, SW; Tse, CM | 1 |
| Arakawa, H; Matsuoka, N; Morita, M; Nishimura, S; Osoda, K; Shirai, F; Yamazaki, M | 1 |
| Hayashi, R; Kitada, N; Kokufu, M; Ohnishi, N; Takara, K; Yamamoto, K; Yokoyama, T | 1 |
| Abdel-Moty, SG; Abou-Ghadir, OM; Hussein, MA; Kafafy, AH | 1 |
| Borda, E; Busch, L; Miozza, V; S-Borda, L | 1 |
| Kong, D; Wan, Y; Wang, Z; Yang, C; Zhou, Z; Zhu, J | 1 |
| Inagi, T; Makino, K; Suzuki, K; Terada, H; Terashima, H; Tomoda, K | 1 |
| Asanuma, M; Kikkawa, Y; Kimoto, N; Miyazaki, I; Miyoshi, K; Murakami, S; Takeshima, M | 1 |
| Bobade, VD; Mhaske, PC; Nandave, M; Narkhade, S; Shelke, SH; Walhekar, NM | 1 |
| Ayon, RJ; Davis, AJ; Duan, DD; Forrest, AS; Freitas, N; Greenwood, IA; Huebner, ML; Joyce, J; Joyce, TC; Leblanc, N; Singer, CA; Valencik, ML; Wiwchar, M; Ye, L | 1 |
| Belo, MA; Castro, MP; Claudiano, Gda S; de Moraes, FR; Loureiro, BA; Manrique, WG; Marcusso, PF; Moraes, JR; Petrillo, TR | 1 |
| Hosoya, K; Kim, S; Oh, N; Okumura, M | 1 |
| An, J; Chen, YY; Lan, Y; Liu, N; Mao, YQ; Wang, Q; Wang, WP; Wu, Q; Zhang, YW; Zhao, BC | 1 |
| Jansson, L; Sandberg, M | 1 |
| Kaushik, D; Kaushik, P; Khloya, P; Kumar, S; Sharma, PK; Surain, P | 1 |
| Matteson, EL; Thongprayoon, C; Ungprasert, P | 1 |
| Hosoi, Y; Murata, Y; Shiga, S; Uehara, Y | 1 |
| Bourn, J; Cekanova, M | 1 |
| Azouz, AA; Bakr, RB; Ghoneim, AA | 1 |
| Abdelmoez, AAB; Abdu-Allah, HHM; El-Awady, R; El-Shorbagi, AA; Tarazi, H | 1 |
| Aalkjaer, C; Chen, H; Simonsen, U | 1 |
| Stachowicz, K | 1 |
3 review(s) available for thiazoles and indomethacin
| Article | Year |
|---|---|
Use of carprofen for the treatment of pain and inflammation in dogs.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carbazoles; Clonixin; Cyclooxygenase Inhibitors; Dog Diseases; Dogs; Ibuprofen; Indomethacin; Ketoprofen; Meclofenamic Acid; Meloxicam; Naproxen; Osteoarthritis; Pain; Phenylbutazone; Piroxicam; Thiazines; Thiazoles | 1997 |
Distribution and expression of cyclooxygenase (COX) isoenzymes, their physiological roles, and the categorization of nonsteroidal anti-inflammatory drugs (NSAIDs).
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Controlled Clinical Trials as Topic; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Etodolac; Gene Expression; Humans; Ibuprofen; Indomethacin; Isoenzymes; Meloxicam; Membrane Proteins; Naproxen; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Thiazines; Thiazoles | 1999 |
Nonaspirin Nonsteroidal Anti-Inflammatory Drugs and Risk of Hemorrhagic Stroke: A Systematic Review and Meta-Analysis of Observational Studies.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cerebral Hemorrhage; Diclofenac; Humans; Ibuprofen; Incidence; Indomethacin; Lactones; Meloxicam; Naproxen; Observational Studies as Topic; Odds Ratio; Piroxicam; Proportional Hazards Models; Stroke; Sulfones; Thiazines; Thiazoles | 2016 |
10 trial(s) available for thiazoles and indomethacin
| Article | Year |
|---|---|
Fentiazac in the treatment of osteoarthritis and tendinitis.
Topics: Acetates; Aged; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Indomethacin; Male; Middle Aged; Osteoarthritis; Phenylbutazone; Random Allocation; Tendinopathy; Thiazoles | 1983 |
Effects of meloxicam and indomethacin on cyclooxygenase pathways in healthy volunteers.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Cyclooxygenase Inhibitors; Dinoprostone; Female; Humans; Indomethacin; Meloxicam; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Therapeutic Equivalency; Thiazines; Thiazoles; Thromboxane B2 | 1997 |
Studies on the protective effect of ebrotidine on experimental ulcers induced by non-steroidal anti-inflammatory drugs in healthy volunteers.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Benzenesulfonates; Carbonic Anhydrases; Female; Gastric Mucosa; Histamine H2 Antagonists; Humans; Indomethacin; Male; Middle Aged; Stomach Ulcer; Thiazoles | 1997 |
Effect of selective inhibition of the inducible cyclooxygenase on renin release in healthy volunteers.
Topics: Adolescent; Adult; Cross-Over Studies; Cyclooxygenase Inhibitors; Dinoprostone; Female; Furosemide; Gas Chromatography-Mass Spectrometry; Humans; Indomethacin; Isoenzymes; Meloxicam; Middle Aged; Prostaglandin-Endoperoxide Synthases; Radioimmunoassay; Reference Values; Renin; Thiazines; Thiazoles | 1998 |
Meloxicam, 15 mg/day, spares platelet function in healthy volunteers.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Blood Platelets; Cross-Over Studies; Cyclooxygenase Inhibitors; Female; Humans; Indomethacin; Male; Meloxicam; Platelet Aggregation; Radioimmunoassay; Reference Values; Thiazines; Thiazoles; Thromboxane B2; Time Factors | 1999 |
[Levels of lipid peroxidation products and activity of antiradical defense enzymes in blood of patients with Bechterew disease].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Drug Therapy, Combination; Female; Free Radicals; Humans; Indomethacin; Lipid Peroxidation; Male; Meloxicam; Spondylitis, Ankylosing; Thiazines; Thiazoles | 2002 |
Effects of meloxicam on platelet function in healthy adults: a randomized, double-blind, placebo-controlled trial.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Bleeding Time; Blood Coagulation; Blood Platelets; Double-Blind Method; Female; Hemorrhage; Humans; Indomethacin; Male; Meloxicam; Middle Aged; Partial Thromboplastin Time; Platelet Aggregation; Platelet Count; Prothrombin Time; Thiazines; Thiazoles; Thromboxane B2 | 2002 |
Prophylaxis of heterotopic ossification after total hip arthroplasty: a prospective randomized study comparing indomethacin and meloxicam.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Cyclooxygenase Inhibitors; Female; Humans; Indomethacin; Male; Meloxicam; Middle Aged; Ossification, Heterotopic; Postoperative Complications; Prospective Studies; Radiography; Severity of Illness Index; Thiazines; Thiazoles | 2002 |
COX 2 selectivity of non-steroidal anti-inflammatory drugs and perioperative blood loss in hip surgery. A randomized comparison of indomethacin and meloxicam.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Blood Loss, Surgical; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Humans; Indomethacin; Isoenzymes; Male; Meloxicam; Membrane Proteins; Middle Aged; Pain Measurement; Pain, Postoperative; Perioperative Care; Prospective Studies; Prostaglandin-Endoperoxide Synthases; Thiazines; Thiazoles; Time Factors | 2003 |
Pharmacokinetic interactions of concomitant administration of febuxostat and NSAIDs.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Cross-Over Studies; Drug Interactions; Febuxostat; Female; Gout Suppressants; Humans; Indomethacin; Male; Metabolic Clearance Rate; Middle Aged; Naproxen; Reference Values; Thiazoles | 2006 |
164 other study(ies) available for thiazoles and indomethacin
| Article | Year |
|---|---|
[Irritative activity of a new anti-inflammatory agent 4-(p-chorophenyl)-2-phenyl-5-thiazoleacetic acid (CH-800) on the gastrointestinal tract in rats (author's transl)].
Topics: Acetates; Administration, Oral; Animals; Anti-Inflammatory Agents; Aspirin; Diclofenac; Digestive System; Ibuprofen; Indomethacin; Irritants; Male; Phenylbutazone; Rats; Stomach Ulcer; Thiazoles | 1979 |
Enhancement of natural and antibody-dependent lymphocyte cytotoxicity by drugs which inhibit prostaglandin production by tumor target cells.
Topics: Antibody-Dependent Cell Cytotoxicity; Aspirin; Cell Line; Cytotoxicity, Immunologic; Dose-Response Relationship, Drug; Humans; Indomethacin; Lymphocytes; Neoplasms, Experimental; Prostaglandin Antagonists; Thiazoles; Time Factors | 1978 |
Inhibitory effect of tiaramide on ADP-induced aggregation in rabbit platelets.
Topics: Adenosine Diphosphate; Animals; Aspirin; Benzothiazoles; Indomethacin; Piperazines; Platelet Aggregation; Rabbits; Thiazoles | 1978 |
Changes in systolic arterial blood pressure in normal and spontaneously hypertensive rats produced by acute administration of inhibitors of prostaglandin biosynthesis.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Benzothiazoles; Blood Pressure; Fenoprofen; Hypertension; Indomethacin; Meclofenamic Acid; Piperazines; Prostaglandin Antagonists; Prostaglandins; Rats; Thiazoles; Tolmetin | 1977 |
[Further studies of the action of an anti-inflammatory agent recently used in therapy].
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Indomethacin; Inflammation; Phenylbutazone; Rats; Thiazoles | 1977 |
A profile of the gastrointestinal toxicity of aspirin, indomethacin, oxaprozin, phenylbutazone, and fentiazac in arthritic and Lewis normal rats.
Topics: Acetates; Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Aspirin; Body Weight; Gastrointestinal Diseases; Indomethacin; Intestine, Small; Male; Oxazoles; Phenylbutazone; Propionates; Rats; Stomach; Thiazoles; Time Factors | 1977 |
The anti-inflammatory and analgesic effects of norvedan a novel, non-steroidal agent.
Topics: Acetates; Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Rheumatoid; Aspirin; Female; Indomethacin; Male; Mice; Phenylbutazone; Rats; Spasm; Thiazoles; Time Factors | 1976 |
Synthesis and anti-inflammatory activity of 2-pyridyl-2-thiobenzothiazole derivatives.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cattle; Dinoprostone; Edema; Free Radicals; Humans; In Vitro Techniques; Indomethacin; Male; Rats; Rats, Wistar; Synovial Fluid; Thiazoles | 1992 |
Platelet-activating factor provokes release of mucin-like glycoproteins from guinea pig respiratory epithelial cells via a lipoxygenase-dependent mechanism.
Topics: Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; Epithelium; Glyceryl Ethers; Guinea Pigs; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Indomethacin; Lipoxygenase; Lipoxygenase Inhibitors; Masoprocol; Mucins; Phospholipid Ethers; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Trachea | 1992 |
A 5-lipoxygenase inhibitor, FR110302, suppresses airway hyperresponsiveness and lung eosinophilia induced by Sephadex particles in rats.
Topics: Acetylcholine; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Chromones; Dextrans; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Indomethacin; Leukotriene B4; Lipoxygenase Inhibitors; Male; Microspheres; Naphthols; Platelet Activating Factor; Prednisolone; Pulmonary Eosinophilia; Pyridines; Quinolines; Rats; Rats, Inbred Strains; SRS-A; Thiazoles | 1992 |
CP-66,948: an antisecretory histamine H2-receptor antagonist with mucosal protective properties.
Topics: Animals; Cimetidine; Dogs; Dose-Response Relationship, Drug; Ethanol; Gastric Acid; Gastric Mucosa; Gastrointestinal Hemorrhage; Guinea Pigs; Heart Rate; Histamine; Imidazoles; In Vitro Techniques; Indomethacin; Male; Pentagastrin; Ranitidine; Rats; Rats, Inbred Strains; Thiazoles; Time Factors | 1991 |
Effect of the selective PAF antagonist SM-10661 on an asthmatic model. 1. Effect on passive anaphylactic bronchoconstriction in guinea pigs.
Topics: Anaphylaxis; Animals; Asthma; Bronchoconstriction; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Indomethacin; Male; Ovalbumin; Platelet Activating Factor; Propranolol; Pyrilamine; SRS-A; Thiazoles; Thiazolidines | 1991 |
BAY P 1455, a thiazolylaminobenzimidazole derivative with gastroprotective properties in the rat.
Topics: Adrenalectomy; Animals; Anti-Ulcer Agents; Benzimidazoles; Cimetidine; Corticosterone; Cysteamine; Duodenal Ulcer; Ethanol; Female; Gastric Acid; Immersion; In Vitro Techniques; Indomethacin; Male; Pirenzepine; Prostaglandins E; Pylorus; Rats; Rats, Inbred Strains; Rioprostil; Stomach Ulcer; Stress, Psychological; Thiazoles | 1991 |
PAF-induced conjunctivitis in the rabbit is mediated by peptido-leukotrienes.
Topics: Animals; Azepines; Conjunctiva; Conjunctivitis; Cyclooxygenase Inhibitors; Dicarboxylic Acids; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Indomethacin; Leukotriene B4; Leukotrienes; Lipoxygenase Inhibitors; Male; Platelet Activating Factor; Rabbits; Second Messenger Systems; Tetrazoles; Thiazoles; Thienopyridines; Triazoles | 1990 |
Arachidonic acid metabolites do not mediate modulation of neurotransmitter release by adenosine in rat hippocampus or striatum.
Topics: Acetophenones; Adenosine; Animals; Arachidonic Acid; Arachidonic Acids; Baclofen; Carbachol; Corpus Striatum; Evoked Potentials; Hippocampus; In Vitro Techniques; Indomethacin; Lipoxygenase Inhibitors; Male; Masoprocol; Neurotransmitter Agents; Phospholipases; Rats; Rats, Inbred Strains; Second Messenger Systems; Thiazoles | 1990 |
45Ca2+ movements induced by Ca2+ chloride in isolated rat aorta under K(+)-free conditions.
Topics: Amiloride; Animals; Aorta, Thoracic; Benzothiazoles; Calcium; Calcium Chloride; Calcium Radioisotopes; Flunarizine; In Vitro Techniques; Indomethacin; Lanthanum; Lidocaine; Nifedipine; omega-Conotoxins; Peptides, Cyclic; Piperidines; Potassium; Rats; Thiazoles; Vasoconstriction | 1991 |
Selective implication of thromboxane A2 and PAF-acether in two guinea pig anaphylactic models.
Topics: Anaphylaxis; Animals; Antigens; Glyceryl Ethers; Guinea Pigs; Immunoglobulin E; Immunoglobulin G; In Vitro Techniques; Indomethacin; Muscle Contraction; Platelet Activating Factor; Thiazoles; Thromboxane A2; Trachea | 1990 |
Ebselen inhibits contractile responses of guinea-pig parenchymal lung strips.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoles; Catechols; Cyclooxygenase Inhibitors; Guinea Pigs; Histamine; Indomethacin; Isoindoles; Isoquinolines; Lung; Male; Masoprocol; Muscle Contraction; Muscle, Smooth; Organoselenium Compounds; Piperazines; Potassium Chloride; Selenium; Thiazoles | 1990 |
Free radical scavenging capacity and anti-inflammatory activity of CBS-113 A.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dexamethasone; Free Radical Scavengers; Free Radicals; In Vitro Techniques; Indomethacin; Iron; Liposomes; Male; Oxygen Consumption; Peroxides; Phosphatidylcholines; Rabbits; Superoxides; Thiazoles; Uveitis; Xanthine Oxidase | 1990 |
[Experimental herpes simplex keratitis in rabbits. Evaluation of pro-infectious effects of topical non-steroidal anti-inflammatory agents].
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Evaluation; Flurbiprofen; Indomethacin; Infections; Keratitis, Dendritic; Rabbits; Thiazoles; Time Factors | 1989 |
Triwaglerin: a potent platelet aggregation inducer purified from Trimeresurus wagleri snake venom.
Topics: Animals; Calcium Channel Blockers; Chromatography, Affinity; Chromatography, Gel; Chromatography, Ion Exchange; Colforsin; Crotalid Venoms; Electrophoresis, Disc; Esterases; Indomethacin; Kinetics; Nitroprusside; Peptides; Platelet Aggregation; Pyrimidinones; Rabbits; Species Specificity; Tetracaine; Thiazoles | 1989 |
Comparison of the effects of indomethacin, RHC80267 and R59022 on superoxide production by 1,oleoyl-2,acetyl glycerol and A23187 in human neutrophils.
Topics: Angiotensin-Converting Enzyme Inhibitors; Calcimycin; Cyclohexanes; Cyclohexanones; Diglycerides; Glycerides; Humans; In Vitro Techniques; Indomethacin; Kinetics; Neutrophils; Platelet Activating Factor; Pyrimidinones; Superoxides; Thiazoles | 1987 |
The effect of inhibition of both diacylglycerol metabolism and phospholipase A2 activity on superoxide generation by human neutrophils.
Topics: Cyclohexanones; Diacylglycerol Kinase; Humans; Indomethacin; Lipoprotein Lipase; Meclofenamic Acid; Neutrophils; Phospholipases; Phospholipases A; Phospholipases A2; Phosphotransferases; Pyrimidinones; Sodium Fluoride; Superoxides; Thiazoles | 1988 |
Inflammatory effects of acetylglycerylether phosphorylcholine: vascular permeability increase and induction of pleurisy in rats.
Topics: Animals; Azo Compounds; Bradykinin; Capillary Permeability; Dexamethasone; Guinea Pigs; Histamine; Indomethacin; Inflammation; Injections; Leukocyte Count; Male; Methysergide; Phospholipid Ethers; Platelet Activating Factor; Pleural Effusion; Pleurisy; Prostaglandins; Pyrilamine; Rabbits; Rats; Rats, Inbred Strains; Serotonin; Skin; Skin Physiological Phenomena; Thiazoles; Trypan Blue | 1986 |
Prostaglandin-E2 9-ketoreductase from human uterine decidua vera.
Topics: Acetates; Chromatography, High Pressure Liquid; Decidua; Dinoprost; Dinoprostone; Female; Humans; Indomethacin; Kinetics; Molecular Weight; NADP; Progesterone; Prostaglandins E; Prostaglandins F; Thiazoles | 1986 |
Pharmacologic analysis of 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine-induced increases in cutaneous vascular permeability in the rat.
Topics: Animals; Capillary Permeability; Chromones; Dose-Response Relationship, Drug; Indomethacin; Masoprocol; Methysergide; Nifedipine; Phenoxybenzamine; Phospholipid Ethers; Platelet Activating Factor; Pyrilamine; Rats; Theophylline; Thiazoles | 1987 |
Negative inotropic effect of platelet-activating factor on human myocardium: a pharmacological study.
Topics: Calcium; Depression, Chemical; Dose-Response Relationship, Drug; Humans; Indomethacin; Myocardial Contraction; Phospholipid Ethers; Platelet Activating Factor; Quinolinium Compounds; SRS-A; Thiazoles | 1987 |
Vascular responses of platelet-activating factor in the Cebus apella primate and inhibitory profiles of antagonists SRI 63-072 and SRI 63-119.
Topics: Animals; Cebus; Indomethacin; Lung; Macaca mulatta; Male; Papio; Platelet Activating Factor; Platelet Aggregation; Thiazoles; Thrombocytopenia; Thromboxane B2 | 1986 |
Gastric anti-ulcer and cytoprotective properties of 2-(3,4-dimethoxyphenyl)-5-methyl-thiazolidine-4-one in rat experimental ulcers.
Topics: Acetates; Animals; Anti-Ulcer Agents; Cell Survival; Cimetidine; Ethanol; Gastric Mucosa; Indomethacin; Male; Rats; Rats, Inbred Strains; Regional Blood Flow; Stomach Ulcer; Thiazoles | 1986 |
In vitro contractile effect of platelet-activating factor on guinea-pig myometrium.
Topics: Animals; Chromones; Female; Guinea Pigs; In Vitro Techniques; Indomethacin; Myometrium; Oxytocin; Phospholipid Ethers; Platelet Activating Factor; Prostaglandins; Thiazoles; Uterine Contraction | 1986 |
A possible role of antihypertensive polar renomedullary lipid (APRL) and prostaglandin E2 in the kidney in the antihypertensive action of pindolol.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Dinoprostone; Electrolytes; Indomethacin; Kidney; Male; Phospholipid Ethers; Pindolol; Platelet Activating Factor; Prostaglandins E; Rats; Rats, Inbred SHR; Thiazoles | 1985 |
Platelet activating factor-stimulated formation of inositol triphosphate in platelets and its regulation by various agents including Ca2+, indomethacin, CV-3988, and forskolin.
Topics: Animals; Blood Platelets; Calcium; Colforsin; Diterpenes; Dose-Response Relationship, Drug; Indomethacin; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Models, Biological; Phospholipid Ethers; Platelet Activating Factor; Rabbits; Sugar Phosphates; Thiazoles; Time Factors | 1985 |
Inhibition of platelet aggregation by 2-(p-chlorophenyl)-4-thiazoleacrylic acid (Wy-23,049)--comparison with acetylsalicylic acid.
Topics: Acrylates; Adenosine Diphosphate; Animals; Aspirin; Blood Coagulation; Chlorobenzenes; Collagen; Cyclic AMP; Humans; In Vitro Techniques; Indomethacin; Lysine; Platelet Adhesiveness; Platelet Aggregation; Polymers; Prostaglandins; Rats; Rats, Inbred Strains; Thiazoles; Time Factors | 1974 |
Nonsteroidal antiinflammatory agents. 1.2,4-Diphenylthiazole-5-acetic acid and related compounds.
Topics: Acetates; Albumins; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Benzaldehydes; Bradykinin; Carrageenan; Edema; Freund's Adjuvant; Guinea Pigs; Indomethacin; Nitrobenzenes; Phenylbutazone; Protein Binding; Protein Denaturation; Rats; Structure-Activity Relationship; Thiazoles | 1974 |
Delay of parturition in the rat by anti-inflammatory agents which inhibit the biosynthesis of prostaglandins.
Topics: Acetates; Administration, Oral; Animals; Anti-Inflammatory Agents; Aspirin; Cortisone; Depression, Chemical; Female; Fetal Death; Gestational Age; Indomethacin; Injections, Intraperitoneal; Obstetric Labor Complications; Obstetric Labor, Premature; Pregnancy; Prostaglandins; Rats; Thiazoles | 1972 |
Diaryloxazole and diarylthiazolealkanoic acids: two novel series of non-steroidal anti-inflammatory agents.
Topics: Aldehydes; Animals; Anti-Inflammatory Agents; Aspirin; Biological Assay; Carrageenan; Edema; Gastric Mucosa; Gastrointestinal Hemorrhage; Hot Temperature; Humans; Indomethacin; Oxazoles; Phenylbutazone; Protein Denaturation; Rats; Serum Albumin; Thiazoles | 1968 |
Effects of an orally active converting enzyme inhibitor (YS-980) on renal function in dogs.
Topics: 3-Mercaptopropionic Acid; Administration, Oral; Angiotensin-Converting Enzyme Inhibitors; Animals; Aprotinin; Dogs; Hemodynamics; Indomethacin; Kallikreins; Kidney; Kinins; Prostaglandins; Regional Blood Flow; Renin; Sulfhydryl Compounds; Teprotide; Thiazoles; Thiazolidines | 1980 |
Antiviral activity of Wratizolin.
Topics: Animals; Antiviral Agents; Aspirin; Cells, Cultured; Dimethyl Sulfoxide; Female; Flufenamic Acid; Guinea Pigs; Herpes Genitalis; Indomethacin; Interferons; Male; Mefenamic Acid; Ribavirin; Simplexvirus; Thiazoles; Virus Replication | 1983 |
Inhibitory effect of tiaramide of aggregation in vivo and on electrophoresis of rabbit platelets.
Topics: Adenosine Diphosphate; Animals; Aspirin; Benzothiazoles; Cyclic AMP; Depression, Chemical; Electrophoresis; Female; In Vitro Techniques; Indomethacin; Male; Piperazines; Platelet Aggregation; Platelet Count; Prostaglandin Endoperoxides; Rabbits; Thiazoles | 1980 |
Reversal of indomethacin-induced decreases in renal function by an isosterically-modified prostaglandin analog.
Topics: Animals; Diuresis; Dogs; Drug Interactions; Female; Glomerular Filtration Rate; Indomethacin; Kidney; Natriuresis; Regional Blood Flow; Renin; Thiazoles; Thiazolidines | 1983 |
Interaction of Wratizolin with serum albumins and its antiproteolytic activity.
Topics: Animals; Cattle; Chromatography, Gel; Chymotrypsin; Dansyl Compounds; Horses; Humans; In Vitro Techniques; Indomethacin; Ovalbumin; Protease Inhibitors; Protein Binding; Serum Albumin; Serum Albumin, Bovine; Thiazoles; Trypsin Inhibitors; Tryptophan; Uric Acid | 1983 |
Cyclic response of hypophysectomized rats to ovulation induced by LHRH agonist: mediation by prostaglandins.
Topics: Acetates; Adrenalectomy; Animals; Cyclooxygenase Inhibitors; Dinoprost; Estrus; Female; Gonadotropin-Releasing Hormone; Hypophysectomy; Indomethacin; Luteinizing Hormone; Median Eminence; Ovulation Induction; Pentobarbital; Pregnancy; Prostaglandins E; Prostaglandins F; Rats; Rats, Inbred Strains; Thiazoles | 1984 |
Effects of Wratizolin on growth and metabolism of cells in vitro.
Topics: Amnion; Animals; Anti-Inflammatory Agents; Cattle; Cell Line; Cells, Cultured; Chick Embryo; DNA; Fibroblasts; Glucose; Humans; Indomethacin; Kidney; Lactates; Lactic Acid; Lymphocytes; Mice; Swine; Thiazoles; Thymidine | 1983 |
Metabolism of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide by prostaglandin endoperoxide synthetase.
Topics: Animals; Arachidonic Acids; Cyclooxygenase Inhibitors; FANFT; In Vitro Techniques; Indomethacin; Kidney Medulla; Male; Microsomes; Prostaglandin Endoperoxides; Prostaglandin-Endoperoxide Synthases; Rabbits; Seminal Vesicles; Thiazoles | 1980 |
[Inhibitory action of non-steroidal anti-flammatory drugs on prostaglandin synthesis and release (author's transl)].
Topics: Acetates; Animals; Anti-Inflammatory Agents; Aspirin; Depression, Chemical; Diclofenac; Flurbiprofen; Indomethacin; Male; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Rats; Synovial Membrane; Synovitis; Thiazoles | 1980 |
Prostaglandin E inhibits the production of human interleukin 2.
Topics: Acetates; Alprostadil; Cell Adhesion; Dinoprost; Dinoprostone; Female; Humans; Indomethacin; Interleukin-2; Lymphokines; Male; Prostaglandins A; Prostaglandins E; Prostaglandins F; Thiazoles | 1982 |
Co-oxidative metabolism of 2-amino-4-(5-nitro-2-furyl)-thiazole by prostaglandin hydroperoxidase.
Topics: Animals; Arachidonic Acids; Chromatography, Thin Layer; FANFT; Indomethacin; Male; Peroxidases; Prostaglandin Endoperoxides; Rabbits; Thiazoles | 1980 |
Inhibitory effect of KBT-3022, a new anti-platelet agent, on infiltration of polymorphonuclear leukocytes induced by leukotriene B4 or formyl-methionyl-leucyl-phenylalanine in mice.
Topics: Animals; Dexamethasone; Dose-Response Relationship, Drug; Indomethacin; Leukocytes; Leukotriene B4; Mice; Mice, Inbred Strains; N-Formylmethionine Leucyl-Phenylalanine; Platelet Aggregation Inhibitors; Pyrroles; Thiazoles | 1995 |
Anti-thrombotic activity of KBT-3022 in experimental models of thrombosis.
Topics: Animals; Arachidonic Acid; Aspirin; Cyclooxygenase Inhibitors; Extracorporeal Circulation; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Mice; Mice, Inbred Strains; Platelet Aggregation Inhibitors; Pyrroles; Rabbits; Silver Nitrate; Thiazoles; Thrombosis; Ticlopidine | 1995 |
Metabolism resistant isothiazolone inhibitors of cartilage breakdown.
Topics: Animals; Cartilage; Cattle; Indomethacin; Interleukin-1; Matrix Metalloproteinase 3; Metalloendopeptidases; Microsomes; Naproxen; Nasal Septum; Organ Culture Techniques; Oxidation-Reduction; Proteoglycans; Pyrazoles; Pyridines; Structure-Activity Relationship; Thiazoles | 1995 |
Synthesis and antiinflammatory activity of some new thiazole derivatives.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chromatography, Thin Layer; Edema; Indomethacin; Mice; Mice, Inbred AKR; Thiazoles | 1995 |
Characterization and pharmacological modulation of antigen-induced peritonitis in actively sensitized mice.
Topics: Animals; Benzeneacetamides; Cetirizine; Cycloheximide; Dexamethasone; Eosinophils; Histamine Release; Hydroxamic Acids; Indomethacin; Kinetics; Leukocyte Count; Leukotriene B4; Leukotriene C4; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred BALB C; Ovalbumin; Peritoneal Cavity; Peritonitis; Platelet Activating Factor; T-Lymphocytes; Tacrolimus; Terfenadine; Thiazoles; Zymosan | 1993 |
Docosahexaenoic acid, a major constituent of fetal serum and fish oil diets, inhibits IFN gamma-induced Ia-expression by murine macrophages in vitro.
Topics: Animals; Cells, Cultured; Docosahexaenoic Acids; Female; Fetal Blood; Histocompatibility Antigens Class II; Indomethacin; Interferon-gamma; Interleukin-4; Macrophages, Peritoneal; Mice; Mice, Inbred C3H; Serum Albumin; Tetrazolium Salts; Thiazoles | 1995 |
S14080, a peripheral analgesic acting by release of an endogenous circulating opioid-like substance.
Topics: Adrenalectomy; Analgesics; Animals; Arginine; Dipyrone; Drug Tolerance; Edema; Endorphins; Fever; Hyperalgesia; Indomethacin; Male; Methylene Blue; Nitric Oxide; omega-N-Methylarginine; Pain Measurement; Rats; Rats, Wistar; Thiazoles; Yohimbine | 1995 |
Studies on antiulcer drugs. 7. 2-Guanidino-4-pyridylthiazoles as histamine H2-receptor antagonists with potent gastroprotective effects against nonsteroidal antiinflammatory drug-induced injury.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Blood Flow Velocity; Dogs; Gastric Acid; Gastric Mucosa; Guanidines; Guinea Pigs; Histamine; Histamine H2 Antagonists; Indomethacin; Male; Molecular Structure; Myocardial Contraction; Rabbits; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Thiazoles | 1994 |
Use of enzymatic activity for design of orally administered enteric dosing forms.
Topics: Animals; Azo Compounds; Chemistry, Pharmaceutical; Drug Design; Enzymes; Esterases; Hydrogen-Ion Concentration; Indomethacin; Lipase; Male; Pharmaceutical Vehicles; Rats; Rats, Sprague-Dawley; Solubility; Tablets, Enteric-Coated; Thiazoles | 1993 |
Role of platelet activating factor in the intestinal epithelial secretory and Chinese hamster ovary cell cytoskeletal responses to cholera toxin.
Topics: Animals; CHO Cells; Cholera Toxin; Cricetinae; Cytoskeleton; Diterpenes; Epithelium; Ginkgolides; Ileum; In Vitro Techniques; Indomethacin; Intestinal Mucosa; Lactones; Male; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles | 1994 |
Prevention of spontaneous polyarthritis in NZB/KN mice by treatment with a novel thiazole derivative, SM-8849.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Biphenyl Compounds; Foot; Hindlimb; Indomethacin; Lymphocyte Count; Male; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Peritoneal Cavity; Radiography; Rheumatoid Factor; Spleen; Thiazoles | 1994 |
Primary culture of rat gastric epithelial cells as an in vitro model to evaluate antiulcer agents.
Topics: Acids; Aluminum Hydroxide; Animals; Anti-Ulcer Agents; Cell Division; Cells, Cultured; Colony-Forming Units Assay; Coloring Agents; Drug Evaluation, Preclinical; Epithelial Cells; Gastric Mucosa; Indomethacin; Microscopy, Phase-Contrast; Neutral Red; Rats; Rats, Sprague-Dawley; Sucralfate; Sucrose; Tetrazolium Salts; Thiazoles | 1994 |
Mechanisms of ozolinone-induced renin release and diuresis.
Topics: Animals; Chlorides; Diuresis; Diuretics; Dogs; Female; In Vitro Techniques; Indomethacin; Kidney Glomerulus; Kidney Tubules, Distal; Male; Potassium; Prostaglandins; Renal Circulation; Renin; Stereoisomerism; Thiazoles | 1993 |
Important role of peptide leukotrienes (p-LTs) in the resting tonus of isolated human bronchi.
Topics: Animals; Benzoquinones; Bronchi; Guinea Pigs; Humans; In Vitro Techniques; Indicators and Reagents; Indomethacin; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Lung; Male; Muscle Tonus; Muscle, Smooth; Radioimmunoassay; Thiazoles | 1993 |
Effect of KBT-3022, a new cyclooxygenase inhibitor, on experimental brain edema in vitro and in vivo.
Topics: Animals; Arachidonic Acid; Aspirin; Brain; Brain Edema; Brain Ischemia; Cyclooxygenase Inhibitors; Gerbillinae; Guinea Pigs; In Vitro Techniques; Indomethacin; Lipid Peroxidation; Male; Pyrroles; Thiazoles | 1996 |
Inhibitory effects of the new anti-platelet agent KBT-3022 and its metabolite on rabbit neutrophil function in vitro.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Binding Sites; Calcium; Cell Adhesion; Cilostazol; Complement C3-C5 Convertases; Complement C5a; Cyclooxygenase Inhibitors; Indomethacin; Leukotriene B4; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Aggregation Inhibitors; Pyrroles; Rabbits; Structure-Activity Relationship; Superoxides; Tetradecanoylphorbol Acetate; Tetrazoles; Thiazoles; Ticlopidine | 1996 |
Indomethacin enhances the cytotoxicity of VCR and ADR in human pulmonary adenocarcinoma cells.
Topics: Adenocarcinoma; Adjuvants, Pharmaceutic; Coloring Agents; Doxorubicin; Drug Combinations; Drug Screening Assays, Antitumor; Etoposide; Humans; Indomethacin; Lung Neoplasms; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured; Vincristine | 1997 |
Histamine H2-receptor antagonist action of ebrotidine. Effects on gastric acid secretion, gastrin levels and NSAID-induced gastrotoxicity in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzenesulfonates; Diclofenac; Dose-Response Relationship, Drug; Female; Gastric Acid; Gastrins; Guinea Pigs; Heart Atria; Heart Rate; Histamine; Histamine H2 Antagonists; In Vitro Techniques; Indomethacin; Ketoprofen; Male; Naproxen; Pentagastrin; Ranitidine; Rats; Rats, Sprague-Dawley; Rats, Wistar; Thiazoles | 1997 |
Effect of ebrotidine on ethanol-induced gastric mucosal damage in the rat. Comparative study with other H2-receptor antagonists.
Topics: Animals; Benzenesulfonates; Cimetidine; Dose-Response Relationship, Drug; Ethanol; Famotidine; Female; Gastric Mucosa; Histamine H2 Antagonists; Indomethacin; Peptic Ulcer; Ranitidine; Rats; Rats, Sprague-Dawley; Thiazoles | 1997 |
Induction of tumor necrosis factor-alpha and apoptosis in gastric mucosal injury by indomethacin: effect of omeprazole and ebrotidine.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Apoptosis; Benzenesulfonates; Gastric Mucosa; Indomethacin; Omeprazole; Premedication; Rats; Rats, Sprague-Dawley; Thiazoles; Time Factors; Tumor Necrosis Factor-alpha | 1997 |
Effects of SK&F 86002 on cytokine-stimulated IL6 production in cultured neonatal mouse calvaria and SaOS2 osteoblastic cells: the role of prostaglandins and other mechanisms of action.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cytokines; Humans; Imidazoles; Indomethacin; Interleukin-1; Interleukin-6; Mice; Osteoblasts; Prostaglandins; Skull; Thiazoles; Tumor Necrosis Factor-alpha | 1997 |
Evaluation of pharmacological profile of meloxicam as an anti-inflammatory agent, with particular reference to its relative selectivity for cyclooxygenase-2 over cyclooxygenase-1.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Gastric Mucosa; In Vitro Techniques; Indomethacin; Isoenzymes; Male; Meloxicam; Membrane Proteins; Nitrobenzenes; Piroxicam; Pleurisy; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Sulfonamides; Therapeutic Equivalency; Thiazines; Thiazoles | 1997 |
Effects of meloxicam, compared with other NSAIDs, on cartilage proteoglycan metabolism, synovial prostaglandin E2, and production of interleukins 1, 6 and 8, in human and porcine explants in organ culture.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cartilage; Dinoprostone; Humans; Hydrocortisone; Indomethacin; Interleukin-1; Interleukin-6; Interleukin-8; Interleukins; Meloxicam; Organ Culture Techniques; Prostaglandin-Endoperoxide Synthases; Proteoglycans; Swine; Synovial Fluid; Thiazines; Thiazoles | 1997 |
Central antinociceptive effects of meloxicam on rat spinal cord in vitro.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Electric Stimulation; Female; Hindlimb; Hyperalgesia; In Vitro Techniques; Indomethacin; Isoenzymes; Male; Meloxicam; Membrane Proteins; Pain; Perfusion; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Spinal Cord; Spinal Nerve Roots; Thiazines; Thiazoles | 1998 |
1,25-Dihydroxy vitamin D3 inhibits adipocyte differentiation and gene expression in murine bone marrow stromal cell clones and primary cultures.
Topics: 1-Methyl-3-isobutylxanthine; Adipocytes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Marrow Cells; Calcitriol; Cell Differentiation; Cell Line; Female; Gene Expression; Hydrocortisone; Indomethacin; Mice; Mice, Inbred BALB C; Receptors, Cytoplasmic and Nuclear; Receptors, Glucocorticoid; RNA, Messenger; Stromal Cells; Thiazoles; Thiazolidinediones; Transcription Factors | 1998 |
Tocolytic effect of the cyclooxygenase-2 inhibitor, meloxicam: studies on uterine contractions in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Indomethacin; Meloxicam; Pregnancy; Rats; Rats, Sprague-Dawley; Thiazines; Thiazoles; Tocolytic Agents; Uterine Contraction | 1998 |
Biochemical and pharmacological properties of a new proton pump inhibitor, 2-amino-4,5-dihydropyrido[1,2-a]thiazolo [5,4-g] benzimidazole (YJA20379-5).
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Benzimidazoles; Epirizole; Ethanol; Female; Gastric Acid; Gastric Mucosa; Immersion; Indomethacin; Microsomes; Omeprazole; Peptic Ulcer; Proton Pump Inhibitors; Rats; Rats, Sprague-Dawley; Stress, Psychological; Swine; Thiazoles | 1998 |
Modulating activity of indomethacin to vincristine cytotoxicity in various human carcinoma cells.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Carcinoma; Cell Survival; Coloring Agents; Female; Fibroblasts; Humans; Indomethacin; Lung Neoplasms; Male; Middle Aged; Neoplasms; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured; Vincristine | 1998 |
Effects of the NSAIDs meloxicam and indomethacin on cartilage proteoglycan synthesis and joint responses to calcium pyrophosphate crystals in dogs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Calcium Pyrophosphate; Cartilage; Crystallization; Dog Diseases; Dogs; Humans; Indomethacin; Joints; Meloxicam; Proteoglycans; Synovitis; Thiazines; Thiazoles | 1999 |
15-Deoxy-delta(12,14) prostaglandin J2: a putative endogenous promoter of adipogenesis suppresses the ob gene.
Topics: Adipose Tissue; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Chromans; DNA-Binding Proteins; Dose-Response Relationship, Drug; Down-Regulation; Glucose Transporter Type 4; Humans; Hypoglycemic Agents; Indomethacin; Leptin; Monosaccharide Transport Proteins; Muscle Proteins; Nuclear Proteins; Obesity; Prostaglandin D2; Proteins; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 1999 |
Meloxicam and indomethacin activity on human matrix metalloproteinases in synovial fluid.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Indomethacin; Meloxicam; Metalloendopeptidases; Synovial Fluid; Thiazines; Thiazoles | 1999 |
Endothelin-1, interleukin-4 and nitric oxide synthase modulators of gastric mucosal injury by indomethacin: effect of antiulcer agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Apoptosis; Benzenesulfonates; Endothelin-1; Gastric Mucosa; Indomethacin; Interleukin-4; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Ranitidine; Rats; Rats, Sprague-Dawley; Sialoglycoproteins; Stomach Ulcer; Thiazoles | 1999 |
Cellular and molecular mechanisms of glial scarring and progressive cavitation: in vivo and in vitro analysis of inflammation-induced secondary injury after CNS trauma.
Topics: Animals; Animals, Newborn; Astrocytes; Axons; Brain Injuries; Cell Movement; Cells, Cultured; Cerebral Cortex; Ganglia, Spinal; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Indomethacin; Inflammation; Lipopolysaccharides; Macrophage Activation; Macrophages, Peritoneal; Microscopy, Video; Neurites; Neuroglia; Neurons; Proteoglycans; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidinediones; Zymosan | 1999 |
Estrogen alters relative contributions of nitric oxide and cyclooxygenase products to endothelium-dependent vasodilation.
Topics: Acetylcholine; Animals; Dose-Response Relationship, Drug; Drug Interactions; Estrogens; Female; In Vitro Techniques; Indomethacin; Mesenteric Arteries; Nitric Oxide; Nitroarginine; Ovariectomy; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Thiazoles | 1999 |
Biochemical and pharmacological characteristics of a newly synthesized H+-K+ ATPase inhibitor, YJA20379-1, 2-amino-4,5-dihydro-8-phenylimidazole[2,1-b]thiazolo[5,4-g]benzothiazol e.
Topics: Animals; Anti-Ulcer Agents; Benzothiazoles; Dithiothreitol; Epirizole; Ethanol; Female; Gastric Acid; Gastric Mucosa; Imidazoles; Indomethacin; Male; Proton Pump Inhibitors; Rats; Rats, Sprague-Dawley; Swine; Thiazoles; Time Factors | 1999 |
Hyperalgesia due to nerve injury: role of prostaglandins.
Topics: Animals; Cyclooxygenase Inhibitors; Functional Laterality; Hindlimb; Hyperalgesia; Indomethacin; Male; Meloxicam; Prostaglandins; Pyrazoles; Rats; Rats, Wistar; Sciatic Nerve; Thiazines; Thiazoles; Time Factors | 1999 |
Role of prostaglandins generated by cyclooxygenase-1 and cyclooxygenase-2 in healing of ischemia-reperfusion-induced gastric lesions.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Gastric Mucosa; Gastrins; Gene Expression Regulation, Enzymologic; Indomethacin; Interleukin-1; Isoenzymes; Lactones; Meloxicam; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Regional Blood Flow; Reperfusion Injury; Resveratrol; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stilbenes; Stomach Ulcer; Sulfonamides; Sulfones; Thiazines; Thiazoles; Time Factors | 1999 |
Cyclooxygenase-2 regulates granulocyte-macrophage colony-stimulating factor, but not interleukin-8, production by human vascular cells: role of cAMP.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Arteriosclerosis; Aspirin; Bucladesine; Cells, Cultured; Cyclic AMP; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Epoprostenol; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Indans; Indomethacin; Interleukin-1; Interleukin-8; Isoenzymes; Mammary Arteries; Meloxicam; Membrane Proteins; Muscle, Smooth, Vascular; Neutrophils; Prostaglandin-Endoperoxide Synthases; Saphenous Vein; Sulfonamides; Thiazines; Thiazoles; Tumor Necrosis Factor-alpha | 2000 |
The analgesic effect profile of FR122047, a selective cyclooxygenase-1 inhibitor, in chemical nociceptive models.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Formaldehyde; Humans; Indomethacin; Isoenzymes; Male; Membrane Proteins; Mice; Nitrobenzenes; Pain Measurement; Piperazines; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Sprague-Dawley; Sulfonamides; Thiazoles | 2000 |
Prevention and healing of experimental indomethacin-induced gastric lesions: effects of ebrotidine, omeprazole and ranitidine.
Topics: Animals; Anti-Ulcer Agents; Benzenesulfonates; Disease Models, Animal; Gastric Juice; Histamine H2 Antagonists; Indomethacin; Male; Omeprazole; Ranitidine; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Thiazoles | 2000 |
Preferential inhibition of cyclooxygenase-2 by meloxicam in human rheumatoid synoviocytes.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Blotting, Western; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprostone; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Humans; Immunohistochemistry; Indomethacin; Isoenzymes; Meloxicam; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Synovial Membrane; Thiazines; Thiazoles | 2000 |
The effects of meloxicam, indomethacin or NS-398 on eicosanoid synthesis by fresh human gastric mucosa.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Culture Techniques; Cyclooxygenase 1; Eicosanoids; Humans; Indomethacin; Intestinal Mucosa; Isoenzymes; Meloxicam; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Sulfonamides; Thiazines; Thiazoles | 2000 |
Acute hemodynamic effects of insulin-sensitizing agents in isolated perfused rat hearts.
Topics: Animals; Chromans; Dose-Response Relationship, Drug; Hemodynamics; Hypoglycemic Agents; Indomethacin; Isoxazoles; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Perfusion; Pioglitazone; Prostaglandins; Rats; Rats, Wistar; Rosiglitazone; Thiazoles; Thiazolidinediones; Troglitazone; Vitamin E | 2000 |
Selective cyclooxygenase-2 inhibition prevents alveolar bone loss in experimental periodontitis in rats.
Topics: Alveolar Bone Loss; Alveolar Process; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Cell Count; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Indomethacin; Injections, Subcutaneous; Isoenzymes; Leukocyte Count; Leukocytes, Mononuclear; Leukocytosis; Male; Meloxicam; Molar; Neutrophils; Osteoclasts; Periodontitis; Peroxidases; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Stomach; Thiazines; Thiazoles; Tooth Cervix | 2000 |
Effect of combined leukotriene D(4) and thromboxane A(2) receptor antagonist on mediator-controlled resistance in guinea pigs.
Topics: Administration, Oral; Airway Resistance; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Antigens; Asthma; Benzoquinones; Chromones; Dose-Response Relationship, Drug; Guinea Pigs; Heptanoic Acids; Indomethacin; Leukotriene Antagonists; Leukotriene B4; Leukotriene C4; Leukotriene E4; Lipid Metabolism; Lung; Male; Membrane Proteins; Ovalbumin; Receptors, Leukotriene; Receptors, Thromboxane; Tetrazoles; Thiazoles; Thromboxane B2; Time Factors | 2000 |
Characterization of lipopolysaccharide-induced emesis in conscious piglets: effects of cervical vagotomy, cyclooxygenase inhibitors and a 5-HT(3) receptor antagonist.
Topics: Animals; Antiemetics; Behavior, Animal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Granisetron; Indomethacin; Injections, Intraperitoneal; Isoenzymes; Lipopolysaccharides; Meloxicam; Prostaglandin-Endoperoxide Synthases; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin Antagonists; Sick Role; Swine; Thiazines; Thiazoles; Vagotomy; Vomiting | 2000 |
Effects of steroidal and non-steroidal antiphlogistic drugs on eicosanoid synthesis in irritated skin: studies with the isolated perfused bovine udder.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Cattle; Clobetasol; Clonixin; Culture Techniques; Dinoprostone; Disease Models, Animal; Eicosanoids; Female; Glucocorticoids; Indomethacin; Mammary Glands, Animal; Meloxicam; Skin Physiological Phenomena; Thiazines; Thiazoles | 2001 |
Classic NSAID and selective cyclooxygenase (COX)-1 and COX-2 inhibitors in healing of chronic gastric ulcers.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chronic Disease; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Gastric Mucosa; Gastrins; Indomethacin; Interleukin-1; Isoenzymes; Lactones; Male; Meloxicam; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Radioimmunoassay; Rats; Rats, Wistar; Resveratrol; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stilbenes; Stomach Ulcer; Sulfonamides; Sulfones; Thiazines; Thiazoles; Tumor Necrosis Factor-alpha | 2001 |
Thiazole analogues of the NSAID indomethacin as selective COX-2 inhibitors.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; Indomethacin; Inhibitory Concentration 50; Isoenzymes; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Structure-Activity Relationship; Thiazoles | 2001 |
In vitro effects of E3040, a dual inhibitor of 5-lipoxygenase and thromboxane A(2) synthetase, on eicosanoid production.
Topics: Animals; Arachidonate 5-Lipoxygenase; Benzothiazoles; Dinoprostone; Dose-Response Relationship, Drug; Eicosanoids; Humans; Hydroxyurea; Indomethacin; Leukocytes; Leukotriene B4; Lipoxygenase Inhibitors; Male; Mesalamine; Methacrylates; Neutrophils; Peritoneal Cavity; Prostaglandin-Endoperoxide Synthases; Pyridines; Rats; Rats, Inbred F344; Sheep; Sulfasalazine; Thiazoles; Thromboxane B2; Thromboxane-A Synthase | 2001 |
Effects of non-steroidal antiinflammatory drugs and dexamethasone on the activity and expression of matrix metalloproteinase-1, matrix metalloproteinase-3 and tissue inhibitor of metalloproteinases-1 by bovine articular chondrocytes.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Cattle; Cells, Cultured; Chondrocytes; Collagenases; Dexamethasone; Glucocorticoids; Indomethacin; Interleukin-1; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Matrix Metalloproteinases; Meloxicam; Metalloendopeptidases; Naproxen; Precipitin Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazines; Thiazoles; Tissue Inhibitor of Metalloproteinase-1 | 2001 |
Inhibitors of arachidonic acid metabolism potentiate tumour necrosis factor-alpha-induced apoptosis in HL-60 cells.
Topics: Apoptosis; Arachidonic Acid; Caspase 3; Caspases; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytochrome c Group; Cytosol; Dose-Response Relationship, Drug; Drug Synergism; HL-60 Cells; Humans; Indomethacin; Isoenzymes; Masoprocol; Membrane Proteins; Peroxisome Proliferators; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Tretinoin; Tumor Necrosis Factor-alpha | 2001 |
Acute gastrointestinal permeability responses to different non-steroidal anti-inflammatory drugs.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Chromatography, High Pressure Liquid; Confidence Intervals; Cyclooxygenase Inhibitors; Delayed-Action Preparations; Female; Gastric Mucosa; Humans; Indomethacin; Intestinal Mucosa; Lactulose; Male; Mannitol; Meloxicam; Middle Aged; Naproxen; Permeability; Pyrazoles; Statistics, Nonparametric; Sucrose; Sulfonamides; Thiazines; Thiazoles | 2001 |
Meloxicam inhibits rabbit ovulation.
Topics: Animals; Cyclooxygenase Inhibitors; Female; Indomethacin; Meloxicam; Ovary; Ovulation; Pregnancy; Rabbits; Thiazines; Thiazoles | 2001 |
Stimulated release of arachidonic acid by agonists of the peroxisome proliferator-activated receptor and retinoic acid receptors.
Topics: Alitretinoin; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Celecoxib; Cell Line; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Drug Synergism; Indomethacin; Kinetics; Liver; Prostaglandin D2; Prostaglandins A; Pyrazoles; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Sulfonamides; Thiazoles; Thiazolidinediones; Transcription Factors; Tretinoin | 2001 |
New cyclooxygenase-2 inhibitors for treatment of experimental autoimmune neuritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Indomethacin; Isoenzymes; Male; Meloxicam; Neuritis, Autoimmune, Experimental; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Inbred Lew; Sciatic Nerve; Sulfonamides; Thiazines; Thiazoles | 2002 |
The COX inhibitors indomethacin and meloxicam exhibit anti-emetic activity against cisplatin-induced emesis in piglets.
Topics: Animals; Antiemetics; Antineoplastic Agents; Cisplatin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Indomethacin; Isoenzymes; Male; Meloxicam; Prostaglandin-Endoperoxide Synthases; Swine; Thiazines; Thiazoles; Vomiting | 2002 |
Differential effects of nonsteroidal antiinflammatory drugs on the IL-1 altered expression of plasminogen activators and plasminogen activator inhibitor-1 by articular chondrocytes.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cattle; Cells, Cultured; Chondrocytes; Diclofenac; Dose-Response Relationship, Drug; Gene Expression Regulation; Indomethacin; Interleukin-1; Meloxicam; Naproxen; Plasminogen Activator Inhibitor 1; Plasminogen Activators; Propionates; RNA, Messenger; Thiazines; Thiazoles | 2002 |
Two cases of acute polyarthritis secondary to intravesical BCG adjuvant therapy for superficial bladder cancer.
Topics: Acute Disease; Administration, Intravesical; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Infectious; BCG Vaccine; Humans; Indomethacin; Male; Meloxicam; Middle Aged; Thiazines; Thiazoles; Treatment Outcome; Urinary Bladder Neoplasms | 2002 |
Cyclooxygenase-2 expression by nonsteroidal anti-inflammatory drugs in human airway smooth muscle cells: role of peroxisome proliferator-activated receptors.
Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Survival; Cyclooxygenase 2; Dexamethasone; Dinoprostone; Flurbiprofen; Humans; Indomethacin; Isoenzymes; Lung; Membrane Proteins; Muscle, Smooth; NF-kappa B; Nitrobenzenes; Promoter Regions, Genetic; Prostaglandin Antagonists; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Protein Transport; Receptors, Cytoplasmic and Nuclear; Response Elements; Sulfonamides; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation | 2003 |
[Inhibitory effects of indomethacin and meloxicam on NF-kappa B in mouse peritoneal macrophages].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Electrophoretic Mobility Shift Assay; Indomethacin; Lipopolysaccharides; Macrophages, Peritoneal; Male; Meloxicam; Mice; Mice, Inbred C57BL; NF-kappa B; Thiazines; Thiazoles | 2001 |
[The renal protective effect of selective cyclooxygenase-2 inhibitor on obstructive nephropathy].
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Indomethacin; Isoenzymes; Male; Meloxicam; Nephritis, Interstitial; Prostaglandin-Endoperoxide Synthases; Protective Agents; Rats; Rats, Sprague-Dawley; Thiazines; Thiazoles; Ureteral Obstruction | 2002 |
Indomethacin versus meloxicam for prevention of heterotopic ossification after total hip arthroplasty.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Female; Hip Joint; Humans; Indomethacin; Male; Meloxicam; Middle Aged; Ossification, Heterotopic; Prospective Studies; Range of Motion, Articular; Thiazines; Thiazoles | 2003 |
Interaction among beta-endorphin, nitric oxide and prostaglandins during ovulation in rats.
Topics: Animals; beta-Endorphin; Blotting, Western; Chorionic Gonadotropin; Dinoprostone; Female; Indomethacin; Meloxicam; Models, Animal; Naltrexone; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Ovary; Ovulation; Prostaglandin Antagonists; Rats; Rats, Sprague-Dawley; Thiazines; Thiazoles | 2003 |
Anti-inflammatory effect and low ulcerogenic activity of etodolac, a cyclooxygenase-2 selective non-steroidal anti-inflammatory drug, on adjuvant-induced arthritis in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cyclooxygenase Inhibitors; Diclofenac; Edema; Etodolac; Gastric Mucosa; Indomethacin; Male; Meloxicam; Mice; Peptic Ulcer; Rats; Species Specificity; Thiazines; Thiazoles | 2003 |
Non-steroidal anti-inflammatory drugs affect the methotrexate transport in IEC-6 cells.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine Triphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Cell Line; Coloring Agents; Diclofenac; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flufenamic Acid; Hydrogen-Ion Concentration; Indomethacin; Intestine, Small; Intestines; Methotrexate; Phosphorylation; Rats; Tetrazolium Salts; Thiazoles; Time Factors | 2003 |
The effects of non-steroidal anti-inflammatory compounds on human myometrial contractility.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Humans; Indomethacin; Isoenzymes; Meloxicam; Membrane Proteins; Myometrium; Organic Chemicals; Pregnancy; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrazoles; Sulfonamides; Thiazines; Thiazoles; Uterine Contraction | 2003 |
Effect of selective vs. non-selective cyclo-oxygenase inhibitors on fetal membrane prostaglandin synthesis.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Extraembryonic Membranes; Female; Furans; Humans; Ibuprofen; Indomethacin; Inhibitory Concentration 50; Isoenzymes; Meloxicam; Membrane Proteins; Pregnancy; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Thiazines; Thiazoles | 2003 |
Therapeutic effect of cyclo-oxygenase inhibitors with different isoform selectivity in lipopolysaccharide-induced preterm birth in mice.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Female; Indomethacin; Isoenzymes; Kidney Diseases; Lipopolysaccharides; Meloxicam; Mice; Mice, Inbred ICR; Obstetric Labor, Premature; Pregnancy; Pregnancy Outcome; Prostaglandin-Endoperoxide Synthases; Stomach Diseases; Thiazines; Thiazoles | 2003 |
PPARgamma ligands induce prostaglandin production in vascular smooth muscle cells: indomethacin acts as a peroxisome proliferator-activated receptor-gamma antagonist.
Topics: Animals; Apoptosis; Arachidonic Acid; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Indomethacin; Isoenzymes; Ligands; Models, Biological; Muscle, Smooth, Vascular; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation | 2003 |
Establishment of a human preadipose cell line, HPB-AML-I: refractory to PPARgamma-mediated adipogenic stimulation.
Topics: Adipocytes; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Antineoplastic Agents; Cell Differentiation; Cell Division; Cell Line; Chromans; Flow Cytometry; Fluorescent Antibody Technique; Humans; Hydrocortisone; Immunohistochemistry; Inclusion Bodies; Indomethacin; Leukemia, Myeloid, Acute; Leukocytes, Mononuclear; Microscopy, Electron; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2003 |
Synthesis and anti-inflammatory activity of alkyl/arylidene-2-aminobenzothiazoles and 1-benzothiazol-2-yl-3-chloro-4-substituted-azetidin-2-ones.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azetidines; Carrageenan; Chemical Phenomena; Chemistry, Physical; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Edema; Female; Indicators and Reagents; Indomethacin; Isoenzymes; Male; Membrane Proteins; Mice; Prostaglandin-Endoperoxide Synthases; Rats; Stomach Ulcer; Thiazoles | 2003 |
Effects of dexamethasone and sulfasalazine on prostaglandin E2 output by human placental cells in vitro.
Topics: Animals; Cells, Cultured; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Hydrocortisone; Hydroxyprostaglandin Dehydrogenases; Indomethacin; Meloxicam; Placenta; Pregnancy; Sheep; Sulfasalazine; Thiazines; Thiazoles | 2004 |
Influence of cyclooxygenase inhibitors on the central histaminergic stimulations of hypothalamic - pituitary - adrenal axis.
Topics: Adrenocorticotropic Hormone; Animals; Corticosterone; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Administration Schedule; Histamine; Histamine Agonists; Hypothalamo-Hypophyseal System; Indomethacin; Injections, Intraperitoneal; Injections, Intraventricular; Isoenzymes; Male; Membrane Proteins; Nitrobenzenes; Piroxicam; Pituitary-Adrenal System; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Sulfonamides; Thiazoles | 2003 |
Involvement of bradykinin, cytokines, sympathetic amines and prostaglandins in formalin-induced orofacial nociception in rats.
Topics: Animals; Arachidonic Acids; Atenolol; Behavior, Animal; Biogenic Amines; Bradykinin; Bradykinin B1 Receptor Antagonists; Bradykinin B2 Receptor Antagonists; Captopril; Celecoxib; Cytokines; Dose-Response Relationship, Drug; Drug Synergism; Facial Pain; Formaldehyde; Guanethidine; Hindlimb; Indomethacin; Injections, Subcutaneous; Interleukin-6; Interleukin-8; Lip; Male; Meloxicam; Nociceptors; Prostaglandins; Pyrazoles; Rats; Rats, Wistar; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Sulfonamides; Thiazines; Thiazoles; Tumor Necrosis Factor-alpha; Tyramine | 2004 |
Effects of aminoguanidine and cyclooxygenase inhibitors on nitric oxide and prostaglandin production, and nitric oxide synthase and cyclooxygenase expression induced by lipopolysaccharide in the estrogenized rat uterus.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Down-Regulation; Embryo Loss; Estrogens; Female; Guanidines; Indomethacin; Inflammation; Isoenzymes; Lipopolysaccharides; Meloxicam; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pregnancy; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Wistar; Sulfonamides; Thiazines; Thiazoles; Uterus | 2004 |
Gastric antisecretory and anti-ulcer effect of ME3407, a new benzimidazole derivative, in rats.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Aspirin; Benzimidazoles; Cysteamine; Duodenal Ulcer; Epirizole; Gastric Acid; Gastric Fistula; Gastric Mucosa; Gastrins; Histamine; Immersion; Indomethacin; Male; Pepsin A; Pylorus; Pyridines; Rats; Stomach Ulcer; Thiazoles | 2004 |
Prophylaxis for heterotopic ossification after primary total hip arthroplasty. A cohort study between indomethacin and meloxicam.
Topics: Adult; Aged; Aged, 80 and over; Arthroplasty, Replacement, Hip; Chemoprevention; Cohort Studies; Cyclooxygenase Inhibitors; Female; Humans; Indomethacin; Male; Meloxicam; Middle Aged; Observer Variation; Ossification, Heterotopic; Prospective Studies; Thiazines; Thiazoles; Treatment Outcome | 2004 |
Prostaglandin-mediated control of rat brain kynurenic acid synthesis--opposite actions by COX-1 and COX-2 isoforms.
Topics: Animals; Brain; Diclofenac; Enzyme Inhibitors; Indomethacin; Isoxazoles; Kynurenic Acid; Male; Meloxicam; Prostaglandins; Protein Isoforms; Rats; Rats, Sprague-Dawley; Thiazines; Thiazoles | 2005 |
In vitro studies on controlled-release cellulose acetate films for local delivery of chlorhexidine, indomethacin, and meloxicam.
Topics: Anti-Infective Agents, Local; Anti-Inflammatory Agents; Cellulose; Chlorhexidine; Delayed-Action Preparations; Drug Carriers; In Vitro Techniques; Indomethacin; Meloxicam; Periodontal Diseases; Thiazines; Thiazoles | 2004 |
Pseudomonas aeruginosa lipopolysaccharide induction of keratinocyte proliferation, NF-kappa B, and cyclin D1 is inhibited by indomethacin.
Topics: Blotting, Western; Cell Line, Transformed; Cell Proliferation; Clone Cells; Cyclin D1; Genes, Reporter; Growth Inhibitors; Humans; I-kappa B Proteins; Indomethacin; Keratinocytes; Lipopolysaccharides; Luciferases; NF-kappa B; NF-KappaB Inhibitor alpha; Pseudomonas aeruginosa; Tetrazolium Salts; Thiazoles; Thymidine; Transfection | 2005 |
[Effect of anti-inflammatory drugs on the NF-kappaB activation of HEK293 cells].
Topics: Anti-Inflammatory Agents; Apoptosis; Cell Line; Cell Proliferation; Dexamethasone; Embryo, Mammalian; Humans; Hydrocortisone; Indomethacin; Kidney; Meloxicam; NF-kappa B; Thiazines; Thiazoles | 2005 |
Influence of plasma protein on the potencies of inhibitors of cyclooxygenase-1 and -2.
Topics: Aspirin; Blood Platelets; Blood Proteins; Calcimycin; Calcium; Celecoxib; Cell Line; Cerebrospinal Fluid Proteins; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Humans; Indomethacin; Ionophores; Lactones; Meloxicam; Naproxen; Organ Specificity; Organic Chemicals; Protein Binding; Pyrazoles; Sodium Salicylate; Sulfonamides; Sulfones; Synovial Fluid; Thiazines; Thiazoles; Thromboxane A2 | 2006 |
Cytostatic and cytotoxic effects of cyclooxygenase inhibitors and their synergy with docosahexaenoic acid on the growth of human skin melanoma A-375 cells.
Topics: Antineoplastic Agents; Aspirin; Bromodeoxyuridine; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase Inhibitors; Docosahexaenoic Acids; Drug Synergism; Humans; Indomethacin; Melanoma, Experimental; Piroxicam; Skin Neoplasms; Tetrazolium Salts; Thiazoles | 2005 |
Dual, but not selective, COX-1 and COX-2 inhibitors, attenuate acetic acid-evoked bladder irritation in the anaesthetised female cat.
Topics: Acetic Acid; Anesthesia; Animals; Cats; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Female; Indomethacin; Ketoprofen; Male; Nitrobenzenes; Piperazines; Reflex, Abnormal; Sodium Chloride; Sulfonamides; Thiazoles; Urinary Bladder Diseases | 2006 |
A quantitative approach to measure joint pain in experimental osteoarthritis--evidence of a role for nitric oxide.
Topics: Amidines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Benzylamines; Exudates and Transudates; Indomethacin; Male; Meloxicam; Models, Animal; Morphine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Osteoarthritis; Rats; Rats, Wistar; Stress, Mechanical; Synovial Membrane; Thiazines; Thiazoles | 2006 |
Differential effects of selective cyclooxygenase (COX)-1 and COX-2 inhibitors on anorexic response and prostaglandin generation in various tissues induced by zymosan.
Topics: Animals; Anorexia; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Energy Intake; Escherichia coli; Indomethacin; Lipopolysaccharides; Male; Meloxicam; Mice; Mice, Inbred Strains; Milk; Prostaglandins; Thiazines; Thiazoles; Zymosan | 2006 |
Nonsteroidal anti-inflammatory drugs induce hypermotilinemia and disturbance of interdigestive migrating contractions in instrumented dogs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dogs; Duodenoscopy; Duodenum; Gastrointestinal Motility; Indomethacin; Jejunum; Male; Meloxicam; Motilin; Stomach Ulcer; Thiazines; Thiazoles | 2006 |
Experimental arthritis inhibits the insulin-like growth factor-I axis and induces muscle wasting through cyclooxygenase-2 activation.
Topics: Animals; Arthritis, Experimental; Cachexia; Chronic Disease; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Enzyme Activation; Gene Expression; Growth Hormone; Indomethacin; Insulin-Like Growth Factor Binding Protein 5; Insulin-Like Growth Factor I; Liver; Male; Meloxicam; Muscle Proteins; Muscle, Skeletal; Pituitary Gland; Rats; Rats, Wistar; RNA, Messenger; SKP Cullin F-Box Protein Ligases; Thiazines; Thiazoles; Tripartite Motif Proteins; Tumor Necrosis Factor-alpha; Ubiquitin-Protein Ligases; Weight Gain | 2007 |
The effects of the short-term administration of low therapeutic doses of anti-COX-2 agents on the healing of fractures. An experimental study in rabbits.
Topics: Analysis of Variance; Animals; Bony Callus; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Fracture Healing; Fractures, Bone; Indomethacin; Lactones; Male; Meloxicam; Prednisolone; Rabbits; Sulfones; Thiazines; Thiazoles | 2007 |
Angiogenic function of prostacyclin biosynthesis in human endothelial progenitor cells.
Topics: Adult; Cell Proliferation; Cells, Cultured; Culture Media, Conditioned; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Endothelial Cells; Enzyme Activation; Epoprostenol; Gene Expression Regulation, Enzymologic; Humans; Iloprost; Indomethacin; Leukocytes, Mononuclear; Male; Middle Aged; Neovascularization, Physiologic; PPAR delta; Regeneration; RNA, Small Interfering; Stem Cells; Thiazoles; Tumor Necrosis Factor-alpha; Vasodilator Agents | 2008 |
Endothelial progenitor cells and angiogenesis join the PPARty.
Topics: Adult; Cell Proliferation; Cells, Cultured; Culture Media, Conditioned; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Endothelial Cells; Enzyme Activation; Epoprostenol; Gene Expression Regulation, Enzymologic; Humans; Iloprost; Indomethacin; Leukocytes, Mononuclear; Male; Middle Aged; Neovascularization, Physiologic; PPAR delta; Regeneration; RNA, Small Interfering; Stem Cells; Thiazoles; Tumor Necrosis Factor-alpha; Vasodilator Agents | 2008 |
Membrane fusion: a new function of non steroidal anti-inflammatory drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Dimyristoylphosphatidylcholine; Ibuprofen; Indomethacin; Meloxicam; Membrane Fusion; Piroxicam; Propionates; Thiazines; Thiazoles | 2008 |
The effectiveness of two COX-2 inhibitors in the prophylaxis against heterotopic new bone formation: an experimental study in rabbits.
Topics: Animals; Bone and Bones; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Indomethacin; Injections, Subcutaneous; Isoxazoles; Male; Meloxicam; Ossification, Heterotopic; Osteogenesis; Rabbits; Radiography; Thiazines; Thiazoles | 2009 |
Can in vitro metabolism-dependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose.
Topics: Acetaminophen; Binding Sites; Buspirone; Carbamazepine; Diclofenac; Diphenhydramine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Hepatocytes; Humans; Indomethacin; Meloxicam; Microsomes, Liver; Molecular Structure; Paroxetine; Piperazines; Propranolol; Raloxifene Hydrochloride; Simvastatin; Structure-Activity Relationship; Thiazines; Thiazoles; Ticrynafen; Toxicity Tests; Triazoles | 2008 |
The non-steroidal anti-inflammatory drugs protect mouse cochlea against acoustic injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Auditory Threshold; Cochlea; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Evoked Potentials, Auditory, Brain Stem; Hair Cells, Auditory; Hearing Loss, Noise-Induced; Indomethacin; Isoxazoles; Lipoxygenase Inhibitors; Masoprocol; Meloxicam; Mice; Mice, Inbred Strains; Neuroprotective Agents; Pyrazoles; Sulfones; Thiazines; Thiazoles | 2008 |
Inhibitory effect of nonsteroidal anti-inflammatory drugs on adenosine transport in vascular smooth muscle cells.
Topics: Adenosine; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Cell Proliferation; Cells, Cultured; Coloring Agents; Dose-Response Relationship, Drug; Etodolac; Humans; Indomethacin; Inhibitory Concentration 50; Ketoprofen; Kinetics; Mefenamic Acid; Muscle, Smooth, Vascular; Piroxicam; Sulindac; Temperature; Tetrazolium Salts; Thiazoles; Thioinosine | 2009 |
Effects of non-steroidal anti-inflammatory drugs on Abeta deposition in Abeta(1-42) transgenic C. elegans.
Topics: Amyloid beta-Peptides; Analysis of Variance; Animals; Animals, Genetically Modified; Anti-Inflammatory Agents, Non-Steroidal; Benzothiazoles; Caenorhabditis elegans; Diclofenac; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Ibuprofen; Indomethacin; Microscopy, Confocal; Thiazoles | 2009 |
Effects of nonsteroidal anti-inflammatory drugs on the expression and function of P-glycoprotein/MDR1 in Caco-2 cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Epithelial Cells; Gene Expression Regulation, Neoplastic; Humans; Indomethacin; Inhibitory Concentration 50; Meloxicam; Multidrug Resistance-Associated Proteins; RNA, Messenger; RNA, Small Interfering; Thiazines; Thiazoles | 2009 |
Synthesis and biological activities of new substituted thiazoline-quinoline derivatives.
Topics: Acetophenones; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents; Edema; Fluoroquinolones; Fungi; Gatifloxacin; Gram-Negative Bacteria; Gram-Positive Bacteria; Indomethacin; Ketoconazole; Lethal Dose 50; Male; Mice; Quinolines; Rats; Stomach Ulcer; Thiazoles; Toxicity Tests, Acute | 2009 |
Increase nitric oxide synthase activity in parotid glands from rats with experimental periodontitis.
Topics: Adenine; Amylases; Animals; Calcium; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Egtazic Acid; Enzyme Inhibitors; Guanidines; Indazoles; Indomethacin; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Organ Size; Ornithine; Parotid Gland; Periodontitis; Piperazines; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Salivary Proteins and Peptides; Thiazoles | 2010 |
Folate-conjugated amphiphilic star-shaped block copolymers as targeted nanocarriers.
Topics: Coumarins; Drug Carriers; Fluorescence; Folic Acid; HeLa Cells; Humans; Indomethacin; Magnetic Resonance Spectroscopy; Micelles; Molecular Weight; Nanostructures; Particle Size; Polyesters; Polyethylene Glycols; Propylene Glycols; Surface-Active Agents; Thiazoles | 2011 |
Enhanced transdermal delivery of indomethacin using combination of PLGA nanoparticles and iontophoresis in vivo.
Topics: Administration, Cutaneous; Animals; Coumarins; Drug Delivery Systems; Indomethacin; Iontophoresis; Lactic Acid; Microscopy, Confocal; Nanoparticles; Permeability; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Sprague-Dawley; Skin; Skin Absorption; Thiazoles | 2012 |
Cyclooxygenase-independent neuroprotective effects of aspirin against dopamine quinone-induced neurotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Aspirin; Cell-Free System; Cells, Cultured; Cyclooxygenase Inhibitors; Dopamine Agents; Dopaminergic Neurons; Glutathione; Indomethacin; Levodopa; Meloxicam; Methyldopa; Mice; Neurons; Neuroprotective Agents; Quinones; Sympatholytics; Thiazines; Thiazoles | 2012 |
Synthesis and pharmacological evaluation of a novel series of 3-aryl-2-(2-substituted-4-methylthiazole-5-yl)thiazolidin-4-one as possible anti-inflammatory and antimicrobial agents.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Bacteria; Bacterial Infections; Carrageenan; Edema; Fungi; Humans; Indomethacin; Microbial Sensitivity Tests; Mycoses; Rats; Thiazoles; Thiazolidines | 2012 |
Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension.
Topics: Animals; Anoctamin-1; Calcium Channel Blockers; Chloride Channel Agonists; Chloride Channels; Cyclooxygenase Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Indomethacin; Male; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nifedipine; Niflumic Acid; Patch-Clamp Techniques; Pulmonary Artery; Pyrimidines; Rats; Rats, Wistar; Serotonin; Thiazoles | 2012 |
Acute aerocystitis in Piaractus mesopotamicus: participation of eicosanoids and pro-inflammatory cytokines.
Topics: Aeromonas hydrophila; Animals; Anti-Inflammatory Agents; Bacterial Vaccines; Capillary Permeability; Cellular Structures; Characidae; Cytokines; Dexamethasone; Dose-Response Relationship, Drug; Eicosanoids; Gram-Negative Bacterial Infections; Indomethacin; Meloxicam; Thiazines; Thiazoles; Time Factors; Vaccines, Inactivated | 2013 |
Compensatory cellular reactions to nonsteroidal anti-inflammatory drugs on osteogenic differentiation in canine bone marrow-derived mesenchymal stem cells.
Topics: Alkaline Phosphatase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium; Carbazoles; Cell Differentiation; Dinoprostone; Diphenylamine; DNA Primers; Dogs; Gene Expression Profiling; Gene Expression Regulation; Genetic Markers; Immunoassay; Indomethacin; Interleukin-1beta; Meloxicam; Mesenchymal Stem Cells; Osteocalcin; Osteogenesis; Phenylacetates; Statistics, Nonparametric; Thiazines; Thiazoles | 2014 |
Cytotoxicity and enhancement activity of essential oil from Zanthoxylum bungeanum Maxim. as a natural transdermal penetration enhancer.
Topics: Administration, Cutaneous; Animals; Cell Line; Cell Line, Tumor; Fibroblasts; Fluorouracil; Humans; Indomethacin; Inhibitory Concentration 50; Keratinocytes; Male; Oils, Volatile; Plant Oils; Rats; Rats, Sprague-Dawley; Skin; Skin Absorption; Solubility; Spectroscopy, Fourier Transform Infrared; Tetrazolium Salts; Thiazoles; Zanthoxylum | 2014 |
Effects of cyclooxygenase inhibition on insulin release and pancreatic islet blood flow in rats.
Topics: Animals; Blood Flow Velocity; Blood Glucose; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Duodenum; Glucose; Indomethacin; Insulin; Islets of Langerhans; Lactones; Male; Membrane Proteins; Piperazines; Pyrazoles; Rats; Rats, Wistar; Regional Blood Flow; Sulfones; Thiazoles | 2014 |
Synthesis and biological evaluation of pyrazolylthiazole carboxylic acids as potent anti-inflammatory-antimicrobial agents.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Carboxylic Acids; Edema; Fungi; Gram-Positive Bacteria; Indomethacin; Microbial Sensitivity Tests; Pyrazoles; Rats; Thiazoles | 2015 |
NSAIDs diclofenac, indomethacin, and meloxicam highly upregulate expression of ICAM-1 and COX-2 induced by X-irradiation in human endothelial cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Contraindications; Cyclooxygenase 2; Diclofenac; E-Selectin; Heart; Human Umbilical Vein Endothelial Cells; Humans; Indomethacin; Intercellular Adhesion Molecule-1; Meloxicam; Myocardial Infarction; Myocardium; NF-kappa B; Nitriles; Risk Factors; Sulfones; Thiazines; Thiazoles; Up-Regulation; Vascular Cell Adhesion Molecule-1 | 2016 |
Cyclooxygenase inhibitors potentiate receptor tyrosine kinase therapies in bladder cancer cells in vitro.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Axitinib; Benzamides; Caspases; Cell Line, Tumor; Cell Survival; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Dogs; Dose-Response Relationship, Drug; Drug Synergism; Humans; Imidazoles; Indazoles; Indomethacin; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-kit; Pyridines; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Thiazoles; Urinary Bladder Neoplasms | 2018 |
Selective cyclooxygenase inhibition and ulcerogenic liability of some newly prepared anti-inflammatory agents having thiazolo[4,5-d]pyrimidine scaffold.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Edema; Formaldehyde; Indomethacin; Male; Molecular Docking Simulation; Molecular Structure; Rats; Rats, Wistar; Sheep; Structure-Activity Relationship; Thiazoles; Ulcer | 2019 |
Conjugation of 4-aminosalicylate with thiazolinones afforded non-cytotoxic potent in vitro and in vivo anti-inflammatory hybrids.
Topics: Administration, Oral; Aminosalicylic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 15-Lipoxygenase; Carrageenan; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Edema; Humans; Indomethacin; Lipoxygenase Inhibitors; Male; Molecular Docking Simulation; Molecular Structure; Rats; Rats, Wistar; Stomach Ulcer; Structure-Activity Relationship; Thiazoles | 2020 |
A sex-specific, COX-derived/thromboxane receptor activator causes depolarization and vasoconstriction in male mice mesenteric resistance arteries.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Diabetes Mellitus, Experimental; Endothelium, Vascular; Fatty Acids, Unsaturated; Female; Hydrazines; Indomethacin; Male; Membrane Potentials; Mesenteric Arteries; Mice; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Obesity; Piperazines; Receptors, Thromboxane; Sex Characteristics; Thiazoles; Vascular Resistance; Vasoconstriction; Vasodilation | 2020 |
Indomethacin, a nonselective cyclooxygenase inhibitor, does not interact with MTEP in antidepressant-like activity, as opposed to imipramine in CD-1 mice.
Topics: Animals; Antidepressive Agents; Cyclooxygenase Inhibitors; Depression; Drug Interactions; Hindlimb Suspension; Imipramine; Indomethacin; Mice; Motor Activity; Pyridines; Receptor, Metabotropic Glutamate 5; Swimming; Thiazoles | 2020 |